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Journal articles on the topic 'Phytol'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Almeida-Bezerra, José Weverton, Saulo Almeida Menezes, José Thyálisson da Costa Silva, et al. "Analysis of the Antibiotic-Potentiating Activity, Absorption, Distribution, Metabolism, and Excretion (ADME) and the Molecular Docking Properties of Phytol Against Multi-Drug-Resistant (MDR) Strains." Antibiotics 13, no. 12 (2024): 1171. https://doi.org/10.3390/antibiotics13121171.

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Background: Phytol is a diterpene from the long-chain unsaturated acyclic alcohols, known for its diverse biological effects, including antimicrobial and anti-inflammatory activities. Present in essential oils, phytol is a promising candidate for various applications in the pharmaceutical and biotechnological sectors. This study aimed to evaluate the in vitro antibacterial and drug-potentiating effects of phytol against multidrug-resistant bacteria and to evaluate its in silico properties: ADME and molecular docking. Methods: The in vitro antibacterial activity of phytol and the phytol combine

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2

Krauß, Stephanie, and Walter Vetter. "Phytol and Phytyl Fatty Acid Esters: Occurrence, Concentrations, and Relevance." European Journal of Lipid Science and Technology 120, no. 7 (2018): 1700387. http://dx.doi.org/10.1002/ejlt.201700387.

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3

Lima, Tábata L. C., Luanda B. F. C. Souza, Lannya C. S. Tavares-Pessoa, et al. "Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach." Pharmaceutics 12, no. 9 (2020): 871. http://dx.doi.org/10.3390/pharmaceutics12090871.

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Phytol is a diterpene alcohol and can be found as a product of the metabolism of chlorophyll in plants. This compound has been explored as a potential antimicrobial agent, but it is insoluble in water. In this study, we describe a novel approach for an interesting anticandidal drug delivery system containing phytol. Different formulations of phytol-loaded solid lipid nanoparticles (SLN) were designed and tested using a natural lipid, 1,3-distearyl-2-oleyl-glycerol (TG1). Different compositions were considered to obtain three formulations with 1:10, 1:5, and 1:3 w/w phytol/TG1 ratios. All the f

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4

Moldoveanu, SC, WM III Coleman, and NP Kulshreshtha. "Evaluation of the Effect of Phytol on the Formation of PAHs in Cigarette Smoke." Beiträge zur Tabakforschung International/Contributions to Tobacco Research 24, no. 1 (2010): 10–23. http://dx.doi.org/10.2478/cttr-2013-0876.

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AbstractPhytol or (2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen- 1-ol (MW = 296.53 a.u.), is naturally present in tobacco at levels around 100-150 µg/g dry leaf, where it is bound in the form of an ester to a porphyrine type group (known as chlorin) with several substituents and chelated to Mg2+ ion, to form chlorophyll. This study evaluated the formation of PAHs when several levels of phytol up to ten times higher than typical phytol level were added on 3R4F cigarettes. The cigarettes were smoked under two different smoking conditions. One regimen (indicated as 35/60) used 35 mL puff volume,

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Ragab, Tamer I. M., Abdulsalam M. Kassem, Heba M. I. Abdallah та ін. "Phytol nanoemulsions encapsulated alginate hydrogel beads for the protection and management of alcohol-induced gastric ulcer via nitric oxide synthase and NF-κB/IL-6/TGF-β modulation". PLOS One 20, № 7 (2025): e0327368. https://doi.org/10.1371/journal.pone.0327368.

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Background Innovative treatment strategies are required for stomach ulcers because of their multifactorial nature. Nanotechnology has emerged as a promising and transformative platform for the formulation and targeted delivery of therapeutic agents. Methods and findings The gastroprotective potential of both in its free form and encapsulated in calcium alginate beads was evaluated against ethanol-induced gastric ulceration in rats. Phytol-loaded nanoemulsions were incorporated into alginate beads to achieve controlled release. Alginate beads showed a pH-dependent release pattern. The release b

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Rosa, Gonçalo P., Ana M. L. Seca, Diana C. G. A. Pinto, and M. Carmo Barreto. "New Phytol Derivatives with Increased Cosmeceutical Potential." Molecules 29, no. 20 (2024): 4917. http://dx.doi.org/10.3390/molecules29204917.

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Natural compounds are widely incorporated into cosmetic products for many purposes. Diterpenes often function as fragrances, enhancing the sensory experience of these formulations. However, current trends in cosmetic science aim to develop multifunctional products, where compounds traditionally used for texture or fragrance also possess biological activities that contribute to the product’s efficacy. In this context, this study focuses on synthesizing derivatives of phytol—a compound already presents in cosmetic formulations—to enhance its anti-aging properties. The derivatives were synthesize

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7

Kim, Eun-Nam, Nguyen Minh Trang, Heesun Kang, Ki Hyun Kim, and Gil-Saeng Jeong. "Phytol Suppresses Osteoclast Differentiation and Oxidative Stress through Nrf2/HO-1 Regulation in RANKL-Induced RAW264.7 Cells." Cells 11, no. 22 (2022): 3596. http://dx.doi.org/10.3390/cells11223596.

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Osteoporosis is a systemic skeletal disorder where osteoclasts are prevalent among osteoblasts. Oxidative stress is one of the main causes of osteoporosis, and nuclear factor erythroid-2-related factor 2 (Nrf2) is the master regulator of antioxidant responses. Phytol, a diterpene isolated from Stevia rebaudiana leaves, has many biological effects, including antimicrobial, antioxidant, and anti-inflammatory effects. This study investigated the crosstalk between Nrf2 and osteoclast differentiation in the presence of phytol. Phytol inhibited osteoclast differentiation through TRAP-positive and F-

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8

Alencar, Marcus V. O. B., Muhammad T. Islam, Eunus S. Ali, et al. "Association of Phytol with Toxic and Cytotoxic Activities in an Antitumoral Perspective: A Meta-Analysis and Systemic Review." Anti-Cancer Agents in Medicinal Chemistry 18, no. 13 (2019): 1828–37. http://dx.doi.org/10.2174/1871520618666180821113830.

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Background: Phytol have various pharmacological activities such as antimicrobial, cytotoxic, antitumoral, antimutagenic, anti-atherogenic, antidiabetic, lipid-lowering, antispasmodic, antiepileptic, antinociceptive, antioxidant, anti-inflammatory, anxiolytic, antidepressant and immunoadjuvant. Several studies point to an association of phytol with implications for apoptosis and necrosis at cellular levels in cancer, yet no clear conclusions were drawn. Method: To clarify this, we conducted a meta-analysis of non-clinical studies of phytol and its associations with toxicity and cytotoxicity emp

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9

AlJabr, Ahmed, Abid Hussain, and Muhammad Rizwan-ul-haq. "Toxin-Pathogen Synergy Reshaping Detoxification and Antioxidant Defense Mechanism of Oligonychus afrasiaticus (McGregor)." Molecules 23, no. 8 (2018): 1978. http://dx.doi.org/10.3390/molecules23081978.

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Current study reveals the likelihood to use pathogen and toxin mutually as an effective and eco-friendly strategy for Oligonychus afrasiaticus (McGregor) management, which could reduce toxicant dose and host killing time. Therefore, phytol and Beauveria bassiana in different proportions were evaluated to determine their effectiveness. Prior to ascertaining host mortality and defense mechanisms, we have recorded in vitro action of phytol using different concentrations (0.70, 1.40, 2.10, 2.80, and 3.50 mg/mL) against B. bassiana suspension. In vitro compatibility assays revealed that growth para

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10

Israel, Adeyomoye Olorunsola, and Adewoye Elsie Olufunke. "Phytol Reduces Oxidative Stress and Cyclooxygenase-2 Expression in Kidney of Diabetic Wistar Rats." Recent Advances in Biology and Medicine 04 (2018): 16. http://dx.doi.org/10.18639/rabm.2018.04.643518.

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Diabetes mellitus is characterized by hyperglycemia, which induces oxidative stress and inflammation. The role of Phytol in oxidative stress and inflammation was investigated in diabetic rats. Fifteen Wistar rats were divided into five groups (n = 5). Groups 1, 2, and 3 served as normal control, diabetic untreated, and diabetic treated with 250 mg/kg Phytol, respectively. Rats were treated for 28 days with Phytol, and then blood samples were collected under sodium thiopental (30 mg/kg i.p) anesthesia for assay. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were d

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11

Atshaves, Barbara P., Avery L. McIntosh, H. Ross Payne, John Mackie, Ann B. Kier, and Friedhelm Schroeder. "Effect of branched-chain fatty acid on lipid dynamics in mice lacking liver fatty acid binding protein gene." American Journal of Physiology-Cell Physiology 288, no. 3 (2005): C543—C558. http://dx.doi.org/10.1152/ajpcell.00359.2004.

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Although a role for liver fatty acid protein (L-FABP) in the metabolism of branched-chain fatty acids has been suggested based on data obtained with cultured cells, the physiological significance of this observation remains to be demonstrated. To address this issue, the lipid phenotype and metabolism of phytanic acid, a branched-chain fatty acid, were determined in L-FABP gene-ablated mice fed a diet with and without 1% phytol (a metabolic precursor to phytanic acid). In response to dietary phytol, L-FABP gene ablation exhibited a gender-dependent lipid phenotype. Livers of phytol-fed female L

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12

Santos, Camila Carolina de Menezes Patrício, Mirian Stiebbe Salvadori, Vanine Gomes Mota, et al. "Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models." Neuroscience Journal 2013 (June 11, 2013): 1–9. http://dx.doi.org/10.1155/2013/949452.

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The objective of the present study was to evaluate the antinociceptive effects of phytol using chemical and thermal models of nociception in mice and to assess its antioxidant effects in vitro. Phytol was administered intraperitoneally (i.p.) to mice at doses of 25, 50, 100, and 200 mg/kg. In the acetic acid-induced writhing test, phytol significantly reduced the number of contortions compared to the control group (P<0.001). In the formalin test, phytol reduced significantly the amount of time spent in paw licking in both phases (the neurogenic and inflammatory phases), this effect being mo

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13

Byju, K., G. Vasundhara, V. Anuradha, S. M. Nair, and N. C. Kumar. "Presence of Phytol, a Precursor of Vitamin E in Chaetomorpha Antinnina." Mapana - Journal of Sciences 12, no. 2 (2013): 57–65. http://dx.doi.org/10.12723/mjs.25.6.

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Phytol, a precursor of vitamin E was identified from green algae Chaetomorpha antinnina collected from Chullickal, Kochi Kerala coast, using GC-MS. Phytol is an acyclic diterpene alcohol that can be used as a precursor for the manufacture of synthetic forms of vitamin E and vitamin K1. The compound 3,7,11,15-tetramethylhexadec-2-en-1-ol also known as phytol which exist naturally only in single isomeric form having molecular formula C20H40O and molecular mass 296. From the total ion chromatogram more than twenty peaks were observed, the mass spectrum of the peak at Rt 21.53 was resolved and the

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14

Adeosun, Idowu J., Itumeleng T. Baloyi, and Sekelwa Cosa. "Anti-Biofilm and Associated Anti-Virulence Activities of Selected Phytochemical Compounds against Klebsiella pneumoniae." Plants 11, no. 11 (2022): 1429. http://dx.doi.org/10.3390/plants11111429.

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The ability of Klebsiella pneumoniae to form biofilm renders the pathogen recalcitrant to various antibiotics. The difficulty in managing K. pneumoniae related chronic infections is due to its biofilm-forming ability and associated virulence factors, necessitating the development of efficient strategies to control virulence factors. This study aimed at evaluating the inhibitory potential of selected phytochemical compounds on biofilm-associated virulence factors in K. pneumoniae, as well as authenticating their antibiofilm activity. Five phytochemical compounds (alpha-terpinene, camphene, fise

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15

Claro-Cala, Carmen M., Elena Grao-Cruces, Rocio Toscano, Maria C. Millan-Linares, Sergio Montserrat-de la Paz, and Maria E. Martin. "Acyclic Diterpene Phytol from Hemp Seed Oil (Cannabis sativa L.) Exerts Anti-Inflammatory Activity on Primary Human Monocytes-Macrophages." Foods 11, no. 15 (2022): 2366. http://dx.doi.org/10.3390/foods11152366.

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Seeds from non-drug varieties of hemp (Cannabis sativa L.) have been used for traditional medicine, food, and fiber production. Our study shows that phytol obtained from hemp seed oil (HSO) exerts anti-inflammatory activity in human monocyte-macrophages. Fresh human monocytes and human macrophages derived from circulating monocytes were used to evaluate both plasticity and anti-inflammatory effects of phytol from HSO at 10–100 mM using FACS analysis, ELISA, and RT-qPCR methods. The quantitative study of the acyclic alcohol fraction isolated from HSO shows that phytol is the most abundant compo

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16

Handoyo, M. Ongky Muji, Yuliani Yuliani, and Erlix Rakhmad Purnama. "Uji in Silico Senyawa Phytol Hasil Ekstrak Daun Zodia (Evodiasuaveolens) sebagai Antikanker." Berkala Ilmiah Pendidikan Biologi (BioEdu) 11, no. 2 (2022): 368–73. http://dx.doi.org/10.26740/bioedu.v11n2.p368-373.

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Kanker merupakan penyakit mematikan ditandai dengan ploriferasi sel atau pembelahan sel yang tidakterkontrol. Pengobatan kanker dengan pembedahan dan radioterapi paling efektif untuk kanker lokal dannon-metastasis. Selain pengobatan secara medis, pasien penderita kanker juga menggunakan pengobatanherbal karena lebih rendahnya efek samping yang diberikan. Tujuan penelitian ini adalah untukmengetahui aktivitas senyawa phytol hasil ekstrak daun Zodia (Evodia sauveolens) sebagai antikankersecara in silico. Teknik penelitian ini secara in silico dimana menggunakan aplikasi komputer yangmelakukan ka

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17

Aachoui, Youssef, and Swapan K. Ghosh. "Novel phytol-based adjuvants in vaccine formulations: Evaluation of safety and efficacy in induction and persistence of specific immune responses (41.64)." Journal of Immunology 182, no. 1_Supplement (2009): 41.64. http://dx.doi.org/10.4049/jimmunol.182.supp.41.64.

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Abstract Adjuvants function as "immunologists' dirty tricks" for enhancement of immune response. However, no two adjuvants work in a similar fashion. Adjuvant efficacy depends on how they influence microenvironment, antigen presentation and retention of immunogens. We are developing water-in-oil emulsion-type adjuvants from phytol (J Immune Based Ther Vaccines 2006, 5:4; ibid 2007; 5: 3). Phytol is a diterpene present in chlorophylls, alpha-tocopherols etc. Phytol derivatives we developed are hydrogenated/nitrated and glycosylated products (US patent pending). Our previous study showed that on

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18

Van Den Branden, Christiane, Joseph Vamecq, Ingrid Wybo, and Frank Roels. "Phytol and Peroxisome Proliferation." Pediatric Research 20, no. 5 (1986): 411–15. http://dx.doi.org/10.1203/00006450-198605000-00007.

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19

Gutbrod, Katharina, Jill Romer, and Peter Dörmann. "Phytol metabolism in plants." Progress in Lipid Research 74 (April 2019): 1–17. http://dx.doi.org/10.1016/j.plipres.2019.01.002.

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20

Tracy, Noah I., Daniel W. Crunkleton, and Geoffrey L. Price. "Gasoline production from phytol." Fuel 89, no. 11 (2010): 3493–97. http://dx.doi.org/10.1016/j.fuel.2010.06.022.

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21

Wang, Shanshan, Hua Wang, Fujie Yan, Jie Wang, and Songbai Liu. "Development of Galloyl Antioxidant for Dispersed and Bulk Oils through Incorporation of Branched Phytol Chain." Molecules 27, no. 21 (2022): 7301. http://dx.doi.org/10.3390/molecules27217301.

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In this study, a novel galloyl phytol antioxidant was developed by incorporating the branched phytol chain with gallic acid through mild Steglich esterification. The evaluation of the radical scavenging activity, lipid oxidation in a liposomal model, and glycerol trioleate revealed its superior antioxidant activities in both dispersed and bulk oils. Then, the antioxidant capacity enhancement of galloyl phytol was further explored using thermal gravimetry/differential thermal analysis (TG/DTA), transmission electron microscopy (TEM), and molecular modeling. The EC50 values of GP, GPa, and GE we

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Tyulkova, E. G., G. E. Savchenko, and L. F. Kabashnikova. "Connectivity of Photosynthesis and Respiration with Content of Chlorophyll Pigments in Plants of Reed Fescue <i>Festuca arundinacea</i> Schreb. Under the Impact of Alkanes and Aromatic Hydrocarbons." Известия Российской академии наук. Серия биологическая, no. 6 (November 1, 2023): 626–39. http://dx.doi.org/10.31857/s1026347022600480.

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The association of degradation of membrane-bound chlorophyll with changes in dark respiration rates and photosynthesis in Festuca arundinacea Schreb. leaves under the influence of various concentrations of limit and aromatic hydrocarbons present in technogenic emissions was studied. 1 day after intoxication a negative correlation between the content of non-phytol forms of pigments and the rate of photosynthesis was found. Positive correlation was found between the content of: 1) phytol forms and the rate of photosynthesis; 2) non-phytol forms and respiration rate. The relationships between the

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Blue, Candice E. C., Mallory B. White, and Rami A. Dalloul. "Assessing the Effects of Phytogenic Feed Additives on Broilers during a Necrotic Enteritis Challenge." Poultry 3, no. 4 (2024): 346–53. http://dx.doi.org/10.3390/poultry3040026.

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Subclinical necrotic enteritis (NE) is an enteric disease that inflicts significant economic losses in the poultry industry, primarily by reducing performance in commercial flocks but without significant mortality. This study evaluated the effects of a variety of phytogenic blends on broilers’ performance and carcass composition during an induced NE challenge. In this study, 1120 day (d)-old male broilers were allocated to four treatments groups (14 replicate floor pens, 20 birds/pen): the control (CONT) group, fed a basal corn-soybean diet, and three phytogenic blend dietary additives (PHYTO1

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Xia, Menglu, Chunping Liu, Lei Gao, and Yanbin Lu. "One-Step Preparative Separation of Phytosterols from Edible Brown Seaweed Sargassum horneri by High-Speed Countercurrent Chromatography." Marine Drugs 17, no. 12 (2019): 691. http://dx.doi.org/10.3390/md17120691.

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Sargassum horneri, a sargassaceae brown alga, is one of the main species in the subtidal seaweeds flora extensively distributed in the Yellow and East China Sea. It has been proven that the phytosterols are an important class of bioactive substances in S. horneri. In this work, a counter-current chromatography approach is proposed for preparative separation of phytol and two analogue sterols from a crude extract of S. horneri. A two-phase solvent system composed of n-hexane-acetonitrile-methanol (5:5:6, v/v) was selected and optimized. The effects of rotary speed and flow rate on the retention

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Mackie, John T., Barbara P. Atshaves, H. Ross Payne, Avery L. McIntosh, Friedhelm Schroeder, and Ann B. Kier. "Phytol-induced Hepatotoxicity in Mice." Toxicologic Pathology 37, no. 2 (2009): 201–8. http://dx.doi.org/10.1177/0192623308330789.

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Singh, Bikram, Pawan Agrawal, and Raghunath Thakur. "Isolation oftrans-Phytol fromPhyllanthus niruri1." Planta Medica 57, no. 01 (1991): 98. http://dx.doi.org/10.1055/s-2006-960039.

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27

McGinty, D., C. S. Letizia, and A. M. Api. "Fragrance material review on phytol." Food and Chemical Toxicology 48 (January 2010): S59—S63. http://dx.doi.org/10.1016/j.fct.2009.11.012.

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28

Lv, Renlong, Mabrouk Elsabagh, Taketo Obitsu, Toshihisa Sugino, and Yuzo Kurokawa. "Effect of phytol in forage on phytanic acid content in cow’s milk." Animal Bioscience 34, no. 10 (2021): 1616–22. http://dx.doi.org/10.5713/ab.21.0086.

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Objective: Bioactive compounds in ruminant products are related to functional compounds in their diets. Therefore, this study aimed to explore the effect of forage sources, Italian ryegrass (IR) silage vs corn silage (CS) in the total mixed ration (TMR), on milk production, milk composition, and phytanic acid content in milk, as well as on the extent of conversion of dietary phytol to milk phytanic acid.Methods: Phytanic acid content in milk was investigated for cows fed a TMR containing either IR silage or CS using 17 cows over three periods of 21 days each. In periods 1 and 3, cows were fed

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Gupta, Deeksha, Bivas Sarker, Keith Thadikaran, Vijay John, Charles Maldarelli, and George John. "Sacrificial amphiphiles: Eco-friendly chemical herders as oil spill mitigation chemicals." Science Advances 1, no. 5 (2015): e1400265. http://dx.doi.org/10.1126/sciadv.1400265.

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Crude oil spills are a major threat to marine biota and the environment. When light crude oil spills on water, it forms a thin layer that is difficult to clean by any methods of oil spill response. Under these circumstances, a special type of amphiphile termed as “chemical herder” is sprayed onto the water surrounding the spilled oil. The amphiphile forms a monomolecular layer on the water surface, reducing the air–sea surface tension and causing the oil slick to retract into a thick mass that can be burnt in situ. The current best-known chemical herders are chemically stable and nonbiodegrada

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Diarte, Clara, Agustí Romero, María Paz Romero, Jordi Graell, and Isabel Lara. "Chemical and Sensory Characterization of Nine Spanish Monovarietal Olive Oils: An Emphasis on Wax Esters." Agriculture 11, no. 2 (2021): 170. http://dx.doi.org/10.3390/agriculture11020170.

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Olive oil is an essential part of the so-called “Mediterranean diet”, purportedly one of the healthiest gastronomic traditions in the world. The wax content in olive oil is regulated under European Union directives, and it is used as a purity parameter for extra-virgin and virgin olive oils. The wax profile may also help the characterization of monovarietal olive oils. In this study, monovarietal oils were extracted from the fruits of nine native Spanish olive varieties (‘Arbequina’, ‘Argudell’, ‘Empeltre’, ‘Farga’, ‘Manzanilla’, ‘Marfil’, ‘Morrut’, ‘Picual’ and ‘Sevillenca’), and their chemic

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Ramírez-Santos, Jesica, Fernando Calzada, Rosa María Ordoñez-Razo, et al. "In Vivo, In Vitro and In Silico Anticancer Activity of Ilama Leaves: An Edible and Medicinal Plant in Mexico." Molecules 29, no. 9 (2024): 1956. http://dx.doi.org/10.3390/molecules29091956.

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Ilama leaves are an important source of secondary metabolites with promising anticancer properties. Cancer is a disease that affects a great number of people worldwide. This work aimed to investigate the in vivo, in vitro and in silico anticancer properties of three acyclic terpenoids (geranylgeraniol, phytol and farnesyl acetate) isolated from petroleum ether extract of ilama leaves. Their cytotoxic activity against U-937 cells was assessed using flow cytometry to determine the type of cell death and production of reactive oxygen species (ROS). Also, a morphological analysis of the lymph node

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Anbalagan, Saranya, Sivakumari Kanakarajan, Rajesh Selvaraj, and Padmavathy Kolappapillai. "In Silico Molecular Docking Analysis of Flavone and Phytol from Vilvam (Aegle marmelos) against Human Hepatocellular Carcinoma (HepG-2) Mitochondrial Proteins." International Journal of Experimental Research and Review 36 (December 30, 2023): 405–14. http://dx.doi.org/10.52756/ijerr.2023.v36.035.

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The vilvam fruit is an important source of phyto compounds, that are a good natural resource for curing several health illnesses. Annually, around 906,000 new cases and 830,000 deaths worldwide are attributed to liver cancer, making it one of the most prevalent malignant tumors. Humans' physical and mental well-being, as well as their social and economic advancement, are seriously threatened by and challenged by liver cancer. The molecular interactions between biological chemicals originating from plants and proteins relevant to apoptosis, however, are not well documented in research. Therefor

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Serebrennikova, O. V., I. V. Russkikh, E. B. Strel’nikova, Yu A. Kharanzhevskaya, and D. V. Fedorov. "Composition of the Organic Compounds of Different Peat Types from the Southern Taiga Subzone of Western Siberia." Химия твердого топлива, no. 2-3 (March 1, 2023): 26–34. http://dx.doi.org/10.31857/s0023117723020135.

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Acyclic (n-alkanes, n-alkan-2-ones, fatty acids, methyl esters of fatty acids, n-aldehydes, squalene, phyton, and phytol isomers) and cyclic (series of di- and triterpenoids, steroids, and tocopherols, phytonadione, and dihydroactinidiolide) organic compounds, many of which are biologically active, in peat samples raised bogs and fens of the southern taiga subzone of Western Siberia were studied using gas chromatography–mass spectrometry. Acyclic structures, among which n-alkan-2-ones were predominant, dominated in sedge and sedge-hypnum peat in contrast to Sphagnum peat, in which n-alkanes pr

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Chaban, N., L. Rapoport, A. Putin, N. Konkova, and L. Bruk. "The selection of phytopreparations for litholysis of phosphate oxalate urinary stones." Bulletin of Science and Practice, no. 3 (March 15, 2017): 106–14. https://doi.org/10.5281/zenodo.399154.

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Тhe possibility of lipolysis of complex composition stones (phosphate oxalate) was shown by using of phytol preparations with different composition in vitro, extracted from the urinary tracts of urological patients. The determination of the stone composition was carried out by infrared spectroscopy. The quality of lipolysis was determined by periodical weighing of stones after each stage of lipolysis. This study will determine perspective compounds of phytol preparations for lipolysis of complicated urinary stones.

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Rontani, Jean-François, Patricia C. Bonin, and John K. Volkman. "Biodegradation of Free Phytol by Bacterial Communities Isolated from Marine Sediments under Aerobic and Denitrifying Conditions." Applied and Environmental Microbiology 65, no. 12 (1999): 5484–92. http://dx.doi.org/10.1128/aem.65.12.5484-5492.1999.

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ABSTRACT Biodegradation of (E)-phytol [3,7,11,15-tetramethylhexadec-2(E)-en-1-ol] by two bacterial communities isolated from recent marine sediments under aerobic and denitrifying conditions was studied at 20°C. This isoprenoid alcohol is metabolized efficiently by these two bacterial communities via 6,10,14-trimethylpentadecan-2-one and (E)-phytenic acid. The first step in both aerobic and anaerobic bacterial degradation of (E)-phytol involves the transient production of (E)-phytenal, which in turn can be abiotically converted to 6,10,14-trimethylpentadecan-2-one. Most of the isoprenoid metab

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Aachoui, Youssef, Richard Fitch, and Swapan Ghosh. "Phytol derivatives as novel immunoadjuvants (87.33)." Journal of Immunology 184, no. 1_Supplement (2010): 87.33. http://dx.doi.org/10.4049/jimmunol.184.supp.87.33.

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Abstract Adjuvants are widely used to influence the course of immune response. Improved adjuvants tailored to immunogens are much sought after. In order to achieve this, we are developing new adjuvants based on chemically modified phytol (J Immune Based Ther. Vaccines 2006, 5:4). We developed hydrogenated/nitrated or glycosylated derivatives of phytol (US patent pending). These compounds exhibit excellent adjuvanticity, and in some respects seem superior to Alum or Freunds’ adjuvants. In this study, we show using cytokine microarray how they influence host microenvironment in the peritoneal la

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Rontani, J. F., and G. Giusti. "Photosensitized oxidation of phytol in seawater." Journal of Photochemistry and Photobiology A: Chemistry 42, no. 2-3 (1988): 347–55. http://dx.doi.org/10.1016/1010-6030(88)80078-9.

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Islam, Muhammad Torequl, Eunüs S. Ali, Shaikh J. Uddin, et al. "Phytol: A review of biomedical activities." Food and Chemical Toxicology 121 (November 2018): 82–94. http://dx.doi.org/10.1016/j.fct.2018.08.032.

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Islam, Md Torequl, Marcus Vinícius Oliveira Barros de Alencar, Katia da Conceição Machado, et al. "Phytol in a pharma-medico-stance." Chemico-Biological Interactions 240 (October 2015): 60–73. http://dx.doi.org/10.1016/j.cbi.2015.07.010.

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Bang, Myun-Ho, Soo Young Choi, Tae-O. Jang, et al. "Phytol, SSADH inhibitory diterpenoid ofLactuca sativa." Archives of Pharmacal Research 25, no. 5 (2002): 643–46. http://dx.doi.org/10.1007/bf02976937.

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Wong, Ho-Fai, and Geoffrey D. Brown. "Photo-oxygenation of Phytol and the Structure Revision of Phytene-1,2-diol from Artemisia annua to Phytene-1-ol-2-Hydroperoxidek." Journal of Chemical Research 2002, no. 1 (2002): 30–33. http://dx.doi.org/10.3184/030823402103170376.

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Photo-oxygenation of racemic phytol has yielded two secondary allylic hydroperoxides and an endoperoxide hemi-acetal, which are the expected products from the “ene-type” reaction of singlet oxygen with the tri-substituted double bond in phytol. Spectral properties for one of the diastereoisomers of phytene-1-ol-2-hydroperoxide obtained from synthesis are shown to be identical with those of a natural product previously reported from Artemisia annua, which, it is concluded, was wrongly assigned as phytene-1,2-diol.

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Aizouq, Mohammed, Helga Peisker, Katharina Gutbrod, Michael Melzer, Georg Hölzl, and Peter Dörmann. "Triacylglycerol and phytyl ester synthesis inSynechocystissp. PCC6803." Proceedings of the National Academy of Sciences 117, no. 11 (2020): 6216–22. http://dx.doi.org/10.1073/pnas.1915930117.

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Cyanobacteria are unicellular prokaryotic algae that perform oxygenic photosynthesis, similar to plants. The cells harbor thylakoid membranes composed of lipids related to those of chloroplasts in plants to accommodate the complexes of photosynthesis. The occurrence of storage lipids, including triacylglycerol or wax esters, which are found in plants, animals, and some bacteria, nevertheless remained unclear in cyanobacteria. We show here that the cyanobacteriumSynechocystissp. PCC6803 accumulates both triacylglycerol and wax esters (fatty acid phytyl esters). Phytyl esters accumulate in highe

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DISCH, Andrea, Jörg SCHWENDER, Christian MÜLLER, Hartmut K. LICHTENTHALER, and Michel ROHMER. "Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714." Biochemical Journal 333, no. 2 (1998): 381–88. http://dx.doi.org/10.1042/bj3330381.

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Isopentenyl diphosphate, the universal isoprenoid precursor, can be produced by two different biosynthetic routes: either via the acetate/mevalonate (MVA) pathway, or via the more recently identified MVA-independent glyceraldehyde phosphate/pyruvate pathway. These two pathways are easily differentiated by incorporation of [1-13C]glucose and analysis of the resulting labelling patterns found in the isoprenoids. This method was successfully applied to several unicellular algae raised under heterotrophic growth conditions and allowed for the identification of the pathways that were utilized for i

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Atshaves, Barbara P., Avery L. McIntosh, Danilo Landrock, et al. "Effect of SCP-x gene ablation on branched-chain fatty acid metabolism." American Journal of Physiology-Gastrointestinal and Liver Physiology 292, no. 3 (2007): G939—G951. http://dx.doi.org/10.1152/ajpgi.00308.2006.

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Despite the importance of peroxisomal oxidation in branched-chain lipid (phytol, cholesterol) detoxification, little is known regarding the factors regulating the peroxisomal uptake, targeting, and metabolism of these lipids. Although in vitro data suggest that sterol carrier protein (SCP)-x plays an important role in branched-chain lipid oxidation, the full physiological significance of this peroxisomal enzyme is not completely clear. To begin to resolve this issue, SCP-x-null mice were generated by gene ablation of SCP-x from the SCP-x/SCP-2 gene and fed a phytol-enriched diet to characteriz

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Binwal, Neha, Prachi Joshi, and Shiv Tewari. "Phytochemical characterization of a leafy liverwort Plagiochila asplenioides using GC-MS analysis." Indian Journal of Forestry 45, no. 4 (2023): 233–37. http://dx.doi.org/10.54207/bsmps1000-2023-8044th.

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The aim of present investigation was to carry out the presence of bioactive compounds found in methanolic extract of a leafy liverwort, Plagiochila asplenioides (L.) Dumort. of the family Plagiochilaceae of Marchantiophyta using Gas Chromatography-Mass Spectrometry (GC-MS). By comparing the retention time and peak area, 16 major phytochemical compounds were identified. Out of which, Azulene, Phytol, Globulol, L (+)-Ascorbic acid 2,6-dihexadecanoate, and Ethyl iso-allocholate were found to be biologically active. The methanolic extract of P. asplenioides prevails potentially bioactive chemicals

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Phoenix, J., R. H. Edwards, and M. J. Jackson. "Inhibition of Ca2+-induced cytosolic enzyme efflux from skeletal muscle by vitamin E and related compounds." Biochemical Journal 257, no. 1 (1989): 207–13. http://dx.doi.org/10.1042/bj2570207.

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1. Efflux of an intracellular enzyme (creatine kinase) from normal rat skeletal muscles was induced by treatment with the Ca2+ ionophore A23187. Addition of alpha-tocopherol (230 microM) to the incubation medium was found to significantly diminish this efflux, and this effect was mimicked by alpha-tocopherol acetate, phytol and isophytol, but not by Trolox C (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid). 2. Analysis of muscle cation content has shown that these protective effects of alpha-tocopherol etc. are not due to an inhibition of the Ca2+ accumulating effects of the ionophore.

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Rontani, Jean-Francois, Patricia C. Bonin, and John K. Volkman. "Production of Wax Esters during Aerobic Growth of Marine Bacteria on Isoprenoid Compounds." Applied and Environmental Microbiology 65, no. 1 (1999): 221–30. http://dx.doi.org/10.1128/aem.65.1.221-230.1999.

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ABSTRACT This paper describes the production of isoprenoid wax esters during the aerobic degradation of 6,10,14-trimethylpentadecan-2-one and phytol by four bacteria (Acinetobacter sp. strain PHY9,Pseudomonas nautica [IP85/617],Marinobacter sp. strain CAB [DSMZ 11874], andMarinobacter hydrocarbonoclasticus [ATCC 49840]) isolated from the marine environment. Different pathways are proposed to explain the formation of these compounds. In the case of 6,10,14-trimethylpentadecan-2-one, these esters result from the condensation of some acidic and alcoholic metabolites produced during the biodegrada

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Maulydia, Nur Balqis, Khairan Khairan, and Teuku Rizky Noviandy. "Prediction of Pharmacokinetic Parameters from Ethanolic Extract Mane Leaves (Vitex pinnata L.) in Geothermal Manifestation of Seulawah Agam Ie-Seu’um, Aceh." Malacca Pharmaceutics 1, no. 1 (2023): 16–21. http://dx.doi.org/10.60084/mp.v1i1.33.

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The Mane plant (Vitex pinnata L.) is traditionally used as medicine in Aceh Province, Indonesia. This study aimed to predict the pharmacokinetic parameters of compounds in the ethanolic extract of Mane leaf (EEML), including the absorption, distribution, metabolism, excretion, and toxicity (ADMET), by in-silico approach. The method used was to analyze the compounds using a web-predictor server and molecular docking. Gas chromatography-mass spectrometry (GCMS) analysis of EEML showed the presence of active compounds, including phytol (60.93%), acorenol (8.56%), n-hexadecanoic acid (4.89%), tran

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Che-Wan-Ngah, Tuan Aini Nadirah, Muhamad Hafiz Che Othman, and Ismanizan Ismail. "Overexpression of amiR2937 and amiR854e in Transgenic Arabidopsis thaliana Indirectly Impacts the Photosynthesis Performances by Targeting Specific Target Transcripts in the MEP Pathway." Pertanika Journal of Tropical Agricultural Science 47, no. 2 (2024): 509–31. http://dx.doi.org/10.47836/pjtas.47.2.12.

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Artificial miRNAs (amiRNAs) are artificial small RNAs engineered to silence specific plant mRNA transcripts. They are generated by expressing a functional microRNA (miRNA) with modified sequences in planta. Two miRNAs, miR2937 and miR854e, were selected based on their predicted target transcript, GGPS2 (geranylgeranyl pyrophosphate synthase 2) and TPS13 (terpenoid synthase 13). In the methylerythritol phosphate pathways, GGPS2 and TPS13 enzymes play a role in synthesizing sesquiterpenes, triterpenes, diterpenoids, carotenoids, gibberellins, and chlorophyll, respectively. Therefore, in this stu

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Ali, Muhammad Shaiq, Muhammad Saleem, Viqar Uddin Ahmad, and Simin Shameel. "Phytol And Glycerol Derivatives From The Marine Green Alga Codium Iyengarii Of The Karachi Coast (Arabian Sea)." Zeitschrift für Naturforschung B 56, no. 8 (2001): 837–41. http://dx.doi.org/10.1515/znb-2001-0818.

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The ethyl acetate soluble part of a methanolic extract of the marine green alga Codium iyengarii, collected from the Karachi coast of the Arabian Sea, afforded four new derivatives of glycerol named : codioside A,B,C,D (1-4), a new derivative of frans-phytol named codioester (5) and rrans-phytol (6). The structures of 1 -5 were elucidated with the aid of acid hydrolysis, methylation, GC-MS, and spectroscopy. The structure of 1 was confirmed through the HMBC NMR technique and the structures of compounds 2 -4 were based on the assignments made for 1

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