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Journal articles on the topic 'Picroside II'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Liu, Qing Shan, Rui Liu, Hong Min He, Jian Cui, Zong Ran Pang, and Xiao Ying Yin. "Preparation and Application of Picroside II Molecularly Imprinted Ploymer for TCM Researching." Advanced Materials Research 287-290 (July 2011): 1987–90. http://dx.doi.org/10.4028/www.scientific.net/amr.287-290.1987.

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PicrosideⅡ, one of the most effective components extracted from picrorhiza, has been reported with neuronal protective activity. To isolate the picroside Ⅱ and similar structure moleculars from picrorhiza effectively, molecularly imprinted polymer (MIP) was prepared by precipitation polymerization with Picroside Ⅱ as template molecule and TRIM as cross-linkers. The MIP was with high affinity and excellent stereo-selectivity toward Picroside Ⅱ and similar structure molecular. The purity of picroside is 70% of target sample. This research might offer a novel method for the enrichment and determi

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2

Sud, Amit, Rajinder Singh Chauhan, and Chanderdeep Tandon. "Mass Spectrometric Analysis of Differentially Expressed Proteins in an Endangered Medicinal Herb,Picrorhiza kurroa." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/326405.

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Picrorhiza kurroagrown in the Northwestern Himalayan region is used in various herbal formulations but extensive harvesting of this plant has led it to near extinction. The active constituents responsible for the medicinal properties ofP. kurroahave been identified as picroside-I and picroside-II which are present in a particular ratio (1 : 1.5) in herbal formulations like Picroliv. The biosynthetic pathway of picrosides has been partially deciphered till date and needs to be elucidated completely. Review of literature revealed that no information is available as of today on the proteome analy

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3

Bhusari, S., A. Chaudhary, G. Shrangare, M. Rindhe, and P. Wakte. "PHYSICOCHEMICAL PROPERTIES DETERMINATION OF PICROSIDE-II." INDIAN DRUGS 56, no. 08 (2019): 27–37. http://dx.doi.org/10.53879/id.56.08.11807.

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The aim of the present study is to determine the physicochemical properties of Picroside-II, a phytochemical obtained from the herb of Picrorhiza kurroa. The solubility study of picroside-II shows that it has better solubility in water up to 2.46 mg/mL than organic solvents. The solubility of picroside-II in linseed oil was found to be 71.46 mg/mL. The solubility of Picroside-II in surfactant like Transcutol P and labrasol was found to be 907.80 and 535.90 mg/mL, respectively. Picroside-II had a melting point in the range of 130 to 135°C. The log P value of picroside-II was estimated using sha

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Wang, L., W. Lv, L. Rong, and G. Liu. "Picroside II Diminishes Oxidative Stress Induced By Cerebral Ischemic Injury In Rats." International Journal of Clinical Therapeutics and Diagnosis 1, no. 4 (2013): 27–31. https://doi.org/10.19070/2332-2926- 130006.

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Objective: To optimize the therapeutic dose and time window of picrosede II in cerebral ischemic injury in rats by orthogonal test. Methods The forebrain ischemia model was established by a bilateral common carotid artery occlusion (BCCAO) Method: Rats were randomly grouped according to orthogonal experimental design and treated by injecting picroside II intraperitonenally at different ischemic times with different doses. The concentration of lipid perioxide malondialdehyde (MDA) in serum and brain was determined by thiobarbituric acid assay. The activity of superoxide dismutase (SOD

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5

Wang, Fanchen, Jiacong Xiao, Miao Li та ін. "Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis". PLOS ONE 19, № 8 (2024): e0308731. http://dx.doi.org/10.1371/journal.pone.0308731.

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Background Picroside II (P-II) is the main bioactive constituent of Picrorhiza Kurroa, a traditional Chinese herb of interest for its proven anti-inflammatory properties. Its beneficial effects have been noted across several physiological systems, including the nervous, circulatory, and digestive, capable of treating a wide range of diseases. Nevertheless, the potential of Picroside II to treat osteoarthritis (OA) and the mechanisms behind its efficacy remain largely unexplored. Aim This study aims to evaluate the efficacy of Picroside II in the treatment of osteoarthritis and its potential mo

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6

Do Yen, Nhi, Huong Nguyen Thi Anh, Phuong Pham Minh, Nhi Trinh Yen, Thuy Le Thi, and Trang Vu Thi. "Simultaneous determination of picroside I and picroside II in dietary supplements by high performance liquid chromatography with PDA detector." Heavy metals and arsenic concentrations in water, agricultural soil, and rice in Ngan Son district, Bac Kan province, Vietnam 7, no. 3 (2024): 226–36. http://dx.doi.org/10.47866/2615-9252/vjfc.4352.

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Picroside I and picroside II are two compounds found in the Picrorhiza Kurroa plant, which have anti-cirrhosis, antioxidant, anti-inflammatory, fever, and asthma effects, etc. They are included in the ingredients of many dietary supplement products that help protect the liver and bile, prevent oxidation, etc. Therefore, determining the content of these two active ingredients in dietary supplements is necessary to evaluate product quality. In this study, highperformance liquid chromatography (HPLC-PDA) was used to simultaneously determine picroside I and picroside II in dietary supplements. The

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7

Lee, Kiram, Jin Choi, Bo Kyong Choi, et al. "Picroside II Isolated from Pseudolysimachion rotundum var. subintegrum Inhibits Glucocorticoid Refractory Serum Amyloid A (SAA) Expression and SAA-induced IL-33 Secretion." Molecules 24, no. 10 (2019): 2020. http://dx.doi.org/10.3390/molecules24102020.

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Chronic obstructive pulmonary disease (COPD) is a major inflammatory lung disease characterized by irreversible and progressive airflow obstruction. Although corticosteroids are often used to reduce inflammation, steroid therapies are insufficient in patients with refractory COPD. Both serum amyloid A (SAA) and IL-33 have been implicated in the pathology of steroid-resistant lung inflammation. Picroside II isolated from Pseudolysimachion rotundum var. subintegrum (Plantaginaceae) is a major bioactive component of YPL-001, which has completed phase-2a clinical trials in chronic obstructive pulm

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8

Ma, Chunmei, та Aijie Shi. "Picroside II prevents inflammation injury in mice with diabetic nephropathy via TLR4/NF-κB pathway". Quality Assurance and Safety of Crops & Foods 13, № 4 (2021): 38–43. http://dx.doi.org/10.15586/qas.v13i4.984.

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The purpose of this study was to investigate the therapeutic effects of picroside II on diabetic nephropathy and reveal the involved underlying signal pathway. Male Sprague–Dawley (SD) mice were used to construct an animal model of streptozotocin (STZ)-induced diabetic nephropathy. Body weight and fasting blood glucose values were recorded. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of proteinuria, blood urea nitrogen (BUN), serum creatinine (Scr), interleukin (IL)-1β, IL-6, monocyte chemoattractant protein-1 (MCP-1) and necrosis factor alpha (TNF-α). Protein expr

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9

Li, Ting, Jian-Wen Liu, Xiao-Dong Zhang, Ming-Chuan Guo, and Guang Ji. "The Neuroprotective Effect of Picroside II from Hu-Huang-Lian against Oxidative Stress." American Journal of Chinese Medicine 35, no. 04 (2007): 681–91. http://dx.doi.org/10.1142/s0192415x0700517x.

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Picroside II is an active constituent extracted from the traditional Chinese medicine (TCM) Hu-Huang-Lian. To evaluate the neuroprotective effect of picroside II, PC12 cells were treated with glutamate in vitro and male ICR mice were treated with AlCl 3in vivo. Pre-treatment of PC12 cells with picroside II could enhance the cell viability and decrease the level of intracellular reactive oxygen species (ROS) induced by glutamate. By DNA fragmentation and flow cytometry assay, picroside II (1.2 mg/ml) significantly prevented glutamate-induced cell apoptosis. In the animal study, amnesia was indu

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10

Xie, Haili, Xiaojie Lu, Weiqiang Jin, et al. "Pharmacokinetics of Picroside I, II, III, IV in Rat Plasma by UPLCMS/ MS." Current Pharmaceutical Analysis 16, no. 4 (2020): 438–45. http://dx.doi.org/10.2174/1573412916666191022161501.

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Background: Modern pharmacological studies show that rhizoma coptidis has protective effects on the liver, gallbladder, kidney, cerebral ischemia-reperfusion, local hypoxia injury, antiinflammatory, bone injury, nerve cells and myocardial cells. The effective components have been isolated from picroside I, II, III and IV. Introduction: A selective and sensitive ultra-performance liquid chromatography electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed for the simultaneous quantitative determination of picroside I, II, III and IV in rat plasma to aid the pharm

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11

Piao, Xuehua, Baohai Liu, Lianyi Guo, Fanji Meng та Leming Gao. "Picroside II Shows Protective Functions for Severe Acute Pancreatitis in Rats by Preventing NF-κB-Dependent Autophagy". Oxidative Medicine and Cellular Longevity 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/7085709.

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Picroside II, from the herbPicrorhiza scrophulariiflora Pennell, has antioxidant and anti-inflammatory activities. However, its function on severe acute pancreatitis (SAP) and molecular mechanism remains unknown. The effects of picroside II on the SAP induced by cerulean were investigated. SAP rats were treated with picroside II (25 mg/kg). The severity of SAP was evaluated by using biochemical and histological analyses. Pancreatic cancer cell PANC-1 was transfected with ptfLC3 (an indicator of autophagic activity), pcDNA3.1-NF-κB (nuclear factor kappa B), and pTZU6+1-NF-κB-shRNA and then trea

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12

Thani, Parbat Raj, and Yash Pal Sharma. "Standardization of Storage Conditions and Duration on Picroside-I and Picroside-II in Raw Material of Drug Kutki (Picrorhiza kurroa Royle ex Benth.)." Nepal Journal of Science and Technology 17, no. 1 (2016): 23–26. http://dx.doi.org/10.3126/njst.v17i1.25059.

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The study of the proper storage of medicinal plants after being harvested becomes necessary to minimize the loss of active constituents from microbial reactions, heat, moisture, light and enzymes etc. In the present study, fresh rhizomes of Picrorhiza kurroa (Kutki) were collected from 2600 m to 3300 m altitude of Himachal Pradesh (Rohtang area), India. The harvested material was washed to remove soil and other adhering materials, and then cut into small pieces and dried under shade. The air dried samples were packed in the different packing materials (i.e. Gunny bags or poly bags), stored eit

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13

Bantawa, Pranay. "Biotechnological Approach for the Conservation of Picrorhiza scrophulariiflora Pennell." International Journal of Basic and Applied Biology 4, no. 2 (2017): 106–11. https://doi.org/10.5281/zenodo.6477219.

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Out of 814 threatened plants of India, <em>Picrorhiza scrophulariiflora</em> Pennell (Scrophulariaceae) is one such threatened species of Indian Himalayan region, having medicinal properties. Even though its existence is in threat due to anthropogenic as well as some other ecological factors, yet there is no any report on proper conservation measures. To check the exact current population status of both the species, the selected populations were analyzed using vertical belt transact model, which revealed that the <em>P. scrophulariiflora</em> is vulnerable in Sikkim Himalayas. Therefore, in or

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14

Piao, Xuehua, Baohai Liu, Xiaodan Sui та ін. "Picroside II Improves Severe Acute Pancreatitis-Induced Intestinal Barrier Injury by Inactivating Oxidative and Inflammatory TLR4-Dependent PI3K/AKT/NF-κB Signaling and Improving Gut Microbiota". Oxidative Medicine and Cellular Longevity 2020 (13 квітня 2020): 1–12. http://dx.doi.org/10.1155/2020/3589497.

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Background. Picroside II exerts anti-inflammatory and antidiarrheal effects for treating the diseases associated with oxidative injury. However, its function on pancreatitis-induced intestinal barrier injury remains unclear. Hypothesis/Purpose. We hypothesized that picroside II will have protective effects against pancreatitis-induced intestinal barrier injury by affecting oxidative and inflammatory signaling (Toll-like receptor 4- (TLR4-) dependent phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and nuclear factor kappa B (NF-κB)). Study Design and Methods. A Sprague-Dawley (SD)

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15

Piao, Xuehua, Xiaodan Sui, Baohai Liu, Tingfang Cui, and Zinan Qi. "Picroside II Improves Severe Acute Pancreatitis-Induced Hepatocellular Injury in Rats by Affecting JAK2/STAT3 Phosphorylation Signaling." BioMed Research International 2021 (July 27, 2021): 1–12. http://dx.doi.org/10.1155/2021/9945149.

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Picroside II is an important ingredient agent in Traditional Chinese medicine and hoped to reduce hepatocellular injury caused by severe acute pancreatitis (SAP). An SAP-induced hepatocellular injury model was established in rats by using pentobarbital sodium. 27 rats were divided into 3 groups: the sham group (SG), model group (MG), and Picroside groups (PG). SAP-induced hepatocellular injury was assessed using hematoxylin and eosin staining. We measured hepatocellular enzymes (amylase (AMY), alanine aminotransferase (ALT), and aspartate aminotransferase (AST)), oxidative stress factors (supe

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16

Wang, Zhibin, Xuepeng Shi, Shuang Jiang, et al. "Simultaneous Determination of Five Iridoids of Picrorhiza scrophulariiflora in Rat Plasma Using UHPLC-ESI-MS/MS." Molecules 28, no. 15 (2023): 5925. http://dx.doi.org/10.3390/molecules28155925.

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In this study, we developed an ultra-performance liquid chromatography-electrospray tandem quadrupole mass spectrometry (UHPLC-ESI-MS/MS) method to simultaneously determine Picroside-I, Picroside-II, Picroside-III, minecoside, and sweroside in rat plasma. The chromatographic column was an ACQUITY UHPLC® BEH Amide Column (2.1 × 100 mm, 1.7 µm; Waters, MA, USA), column temperature 40 °C. The mobile phase was 0.1% formic acid aqueous solution–0.1% formic acid acetonitrile solution. The flow rate was 0.4 mL/min. Multiple reaction monitoring (MRM) and negative ion modes were adopted. The results sh

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17

Veeresham, Ciddi, Yamjala Ganeshkumar, and Ajmera Ramarao. "Picroside I and picroside II from tissue cultures of Picrorhiza kurroa." Pharmacognosy Research 9, no. 5 (2017): 53. http://dx.doi.org/10.4103/pr.pr_89_17.

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18

Singh, Narendra, Ajai P. Gupta, Bikram Singh, and V. K. Kaul. "Quantification of Picroside‐I and Picroside‐II in Picrorhiza kurroa by HPTLC." Journal of Liquid Chromatography & Related Technologies 28, no. 11 (2005): 1679–91. http://dx.doi.org/10.1081/jlc-200060439.

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19

Tiwari, Shashi Shankar, Madan Mohan Pandey, Sharad Srivastava, and AKS Rawat. "TLC densitometric quantification of picrosides (picroside-I and picroside-II) in Picrorhiza kurroa and its substitute Picrorhiza scrophulariiflora and their antioxidant studies." Biomedical Chromatography 26, no. 1 (2011): 61–68. http://dx.doi.org/10.1002/bmc.1626.

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20

Bhusari, Sachin Shivling, Gayatri Borse, and Pravin Wakte. "Development and Validation of UV-Visible Spectrophotometric method for simultaneous estimation of Etoposide and Picroside-II in bulk and pharmaceutical formulation." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 257–62. http://dx.doi.org/10.22270/jddt.v9i3.2868.

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Aim: To develop and validate a simple, precise, accurate, and sensitive UV-visible spectrophotometric method for the simultaneous estimation of Etoposide (ETO) and Picroside-II (PK-II) in a bulk and pharmaceutical formulation according to the ICH guidelines. Methods: The absorption spectra of ETO and PK-II were carried out over the range of 200-800 nm, and absorption maxima were determined. Multiple calibration standards were prepared of both the drugs separately, and absorbance were recorded at respective λmax. Calibration curve were plotted and the linear responses were studied. Various anal

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21

Shitiz, Kirti, Saurabh Pandit, Sreekrishna Chanumolu, et al. "Mining simple sequence repeats inPicrorhiza kurroatranscriptomes for assessing genetic diversity among accessions varying for picrosides contents." Plant Genetic Resources 15, no. 1 (2015): 79–88. http://dx.doi.org/10.1017/s1479262115000404.

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Picrorhiza kurroa(family Scrophulariaceae) is a high value medicinal herb used in herbal drug formulations like picroliv, picrolax, etc. It has been collected recklessly from its natural habitat posing endangered status for its existence, thereby necessitating characterization of genetic diversity for its sustainable utilization and conservation. In this study, picrosides content and genetic profiles of 26 accessions ofP. kurroafrom different locations in north-western Himalayas have been analysed. Picroside-I (P-I) content ranged from 0.37 to 2.7% in fresh shoots whereas total picrosides cont

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22

GAO, Hua, and Ya-wei ZHOU. "Inhibitory effect of picroside II on hepatocyte apoptosis." Acta Pharmacologica Sinica 26, no. 6 (2005): 729–36. http://dx.doi.org/10.1111/j.1745-7254.2005.00729.x.

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23

Sharma, Seema, Yash Pal Sharma, and Chitra Bhardwaj. "Development and Validation of HPLC Method for Analysis of Picroside-I and Picroside-II in Picrorhiza kurroa." International Research Journal of Pure and Applied Chemistry 17, no. 4 (2019): 1–10. http://dx.doi.org/10.9734/irjpac/2018/47326.

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Patil, Ajit A., Bhusari S. Sachin, Devanand B. Shinde, and Pravin S. Wakte. "Supercritical CO2 Assisted Extraction and LC-MS Identification of Picroside I and Picroside II from Picrorhiza kurroa." Phytochemical Analysis 24, no. 2 (2012): 97–104. http://dx.doi.org/10.1002/pca.2383.

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Zhang, Donghu, Jing Wang, Huansheng Wu, and Qili Chen. "Picroside II disrupts IBDV replication via targeting VP1 polymerase." Veterinary Microbiology 296 (September 2024): 110191. http://dx.doi.org/10.1016/j.vetmic.2024.110191.

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Wakte, Pravin, Ajit Patil, Bhusari Sachin, Munnaza Quazi, Shraddha Jabde, and Devanand Shinde. "Optimization of microwave-assisted extraction for picroside I and picroside II from Picrorrhiza kurroa using Box-Behnken experimental design." Frontiers of Chemical Science and Engineering 8, no. 4 (2014): 445–53. http://dx.doi.org/10.1007/s11705-014-1458-2.

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Patil, Ajit A., Bhusari S. Sachin, Pravin S. Wakte, and Devanand B. Shinde. "Optimized supercritical fluid extraction and effect of ionic liquids on picroside I and picroside II recovery from Picrorhiza scrophulariiflora rhizomes." Journal of Pharmaceutical Investigation 43, no. 3 (2013): 215–28. http://dx.doi.org/10.1007/s40005-013-0068-1.

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28

Noh, Soohwan, Kyung-Seop Ahn, Sei-Ryang Oh, Kyun Ha Kim та Myungsoo Joo. "Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-βSignaling". Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/897272.

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Although acute lung injury (ALI) is a leading cause of death in intensive care unit, effective pharmacologic means to treat ALI patients are lacking. The rhizome ofPicrorhiza scrophulariifloraused in a traditional herbal medicine in Asian countries has been shown to have anti-inflammatory function, and picroside II (PIC II) is known as a major constituent in the plant. Here, we examined whether PIC II has an anti-inflammatory activity, which is applicable for treating ALI. We found that although it is not significantly effective in suppressing proinflammatory factor NF-κB or in activating anti

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Yang, Bin, Yuanfang Kong, Yulong Hu, et al. "Synthesis and Primary Biological Evaluation of Triazole‐Modified Picroside II Compounds." ChemistrySelect 6, no. 48 (2021): 14027–38. http://dx.doi.org/10.1002/slct.202103571.

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30

Shanbhag, Sunil V., and Madhusudan T. Bachute. "Development and validation of RP HPLC method for simultaneous determination of picroside I, picroside II, phyllanthin and boeravinone B in a polyherbal hepatoprotective tablet formulation." Tropical Journal of Pharmaceutical Research 21, no. 3 (2022): 619–27. http://dx.doi.org/10.4314/tjpr.v21i3.23.

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Purpose: To develop and validate RP-HPLC method for simultaneous determination of four active ingredients: picroside I (PSI), picroside II (PSII), phyllanthin (PHY) and boeravinone-B (BVB) in a polyherbal hepatoprotective tablet formulation.Methods: The study was carried out using Waters X-Bridge, C18 (250 mm x 4.6 mm, 5 μm) column with mobile phase consisting of 5 mM ammonium acetate in 10 % methanol and acetonitrile, with gradient programme at dual wavelengths of 220 nm and 274 nm and flow speed of 1 mL.min-1. The procedure was validated with respect to specificity, linearity, precision, acc

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Kılıç, Yiğit, Abdullah Özer, Tolga Tatar, et al. "Effect of picroside II on hind limb ischemia reperfusion injury in rats." Drug Design, Development and Therapy Volume 11 (June 2017): 1917–25. http://dx.doi.org/10.2147/dddt.s132401.

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Chen, Haifeng, Yu Pan, Xiong Ding, and Xiaoli Liu. "Simultaneous Determination of Picroside I and II Using High Performance Liquid Chromatography." Asian Journal of Chemistry 26, no. 22 (2014): 7512–14. http://dx.doi.org/10.14233/ajchem.2014.16673.

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Li, Qin, Zhen Li, Xin-ying Xu, Yun-liang Guo, and Fang Du. "Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia." International Journal of Molecular Sciences 11, no. 11 (2010): 4580–90. http://dx.doi.org/10.3390/ijms11114580.

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Gao, Hua. "Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II." World Journal of Gastroenterology 11, no. 24 (2005): 3671. http://dx.doi.org/10.3748/wjg.v11.i24.3671.

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Deibert, Christopher P., and Johnathan A. Engh. "Picroside II as a Novel Inhibitor of Apoptosis After Cerebral Ischemia in Rats." Neurosurgery 77, no. 2 (2015): N17. http://dx.doi.org/10.1227/01.neu.0000467295.18386.90.

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Li, Tingting, Rongyao Zheng, Lijie Xu, et al. "Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway." Toxicology and Applied Pharmacology 408 (December 2020): 115248. http://dx.doi.org/10.1016/j.taap.2020.115248.

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Liu, Guangyi, Li Zhao, Tingting Wang, Meizeng Zhang, and Haitao Pei. "Optimal therapeutic dose and time window of picroside II in cerebral ischemic injury." Neural Regeneration Research 9, no. 15 (2014): 1437. http://dx.doi.org/10.4103/1673-5374.139460.

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Kumar, H. M. Sampath, Parvinder Pal Singh, Naveed A. Qazi, et al. "Development of novel lipidated analogs of picroside as vaccine adjuvants: Acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice." Vaccine 28, no. 52 (2010): 8327–37. http://dx.doi.org/10.1016/j.vaccine.2010.07.062.

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Lv, Jing, Liyi Pan, Yunhua Ye, and Yawei Zhou. "A sensitive and selective RP-HPLC method for simultaneous determination of picroside-I and picroside-II in rat plasma and its application in pharmacokinetics studies." Journal of Separation Science 30, no. 15 (2007): 2466–72. http://dx.doi.org/10.1002/jssc.200700139.

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Dhami-Shah, Hiteshi, Rama Vaidya, Manasi Talwadekar, et al. "Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells." Journal of Ayurveda and Integrative Medicine 12, no. 3 (2021): 465–73. http://dx.doi.org/10.1016/j.jaim.2021.04.007.

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Meng, Fan-Ji, Zhi-Wen Hou, Yang Li, Ying Yang, and Bo Yu. "The protective effect of picroside II against hypoxia/reoxygenation injury in neonatal rat cardiomyocytes." Pharmaceutical Biology 50, no. 10 (2012): 1226–32. http://dx.doi.org/10.3109/13880209.2012.664555.

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Li, Tingting, Lijie Xu, Rongyao Zheng, et al. "Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor." Phytomedicine 68 (March 2020): 153153. http://dx.doi.org/10.1016/j.phymed.2019.153153.

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WANG, LEI, XIUHENG LIU, HUI CHEN, et al. "Effect of picroside II on apoptosis induced by renal ischemia/reperfusion injury in rats." Experimental and Therapeutic Medicine 9, no. 3 (2015): 817–22. http://dx.doi.org/10.3892/etm.2015.2192.

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Wang, Lei, Xiu-Heng Liu, Hui Chen, et al. "Picroside II decreases the development of fibrosis induced by ischemia/reperfusion injury in rats." Renal Failure 36, no. 9 (2014): 1443–48. http://dx.doi.org/10.3109/0886022x.2014.949766.

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Liu, Qing Shan, Li Na Yi, Ke Qin Li, and Xiao Ying Yin. "A Novel Extraction Method for Active Compounds from Traditional Chinese Medicinal Materials Environment Friendly." Advanced Materials Research 726-731 (August 2013): 618–21. http://dx.doi.org/10.4028/www.scientific.net/amr.726-731.618.

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A novel extraction method based on environmental protection was founded through molecularly imprinted polymers (MIPs), overcoming the defects of traditional extraction methods, such as reagents consuming, complex operation and environmental pollution. MIPs were prepared by precipitation polymerization with picroside II or ginsenoside rg1 as the template molecule. The morphology of MIPs was characterized by scanning electron microscope and its static adsorption capacity was measured by the Scatchard equation. In addition, MIPs were filled in the solid phase extraction (SPE) column to separate a

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Zhao, Li, Tingting Wang, Youfei Zhou, Xiaodan Li, Deqiang Wang, and Yunliang Guo. "Improvement in the Ultrastructures of Nervous Tissues Damaged in Cerebral Ischemic Rate by Picroside II." International Journal of Pharmacology 11, no. 1 (2014): 50–55. http://dx.doi.org/10.3923/ijp.2015.50.55.

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Li, Jian-Zhe, Mei-Qing Xie, Dan Mo, et al. "Picroside II protects myocardium from ischemia/reperfusion-induced injury through inhibition of the inflammatory response." Experimental and Therapeutic Medicine 12, no. 6 (2016): 3507–14. http://dx.doi.org/10.3892/etm.2016.3841.

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Yu, Qiao-Ling, Ying Zhao, Xi-Jing Chen, et al. "A Sensitive LC–ESI–MS Method for Pharmacokinetic Studies of Picroside II in Dog Plasma." Chromatographia 67, no. 11-12 (2008): 1013–16. http://dx.doi.org/10.1365/s10337-008-0591-9.

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Wang, Yunkai, Yajun Hong, Chunyu Zhang, et al. "Picroside II attenuates hyperhomocysteinemia-induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis." Journal of Cellular and Molecular Medicine 23, no. 1 (2018): 464–75. http://dx.doi.org/10.1111/jcmm.13949.

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Polat, Yücel, Ali Doğan Dursun, Ayşegül Küçük, Abdullah Özer, Dilek Erer, and Mustafa Arslan. "The Effect of Picroside II on Ischemia-Reperfusion Injury in Myocardial Streptozotocin Induced Diabetic Rats." Free Radical Biology and Medicine 96 (July 2016): S45—S46. http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.094.

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