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Journal articles on the topic 'Piperin'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Jessica, Adhitya, Rifka Naura, Uswatul Hasanah, Erizal Zaini, and Lili Fitriani. "PEMBENTUKAN MULTIKOMPONEN KRISTAL PIPERIN DAN KUERSETIN." JOPS (Journal Of Pharmacy and Science) 4, no. 2 (2021): 1–11. http://dx.doi.org/10.36341/jops.v4i2.1881.

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Penggunaan klinis piperin masih terbatas karena memiliki kelarutan rendah di dalam air. Kuersetin dikenal sebagai bioenhancer yang dapat meningkatkan bioavailibilitas senyawa lain. Penelitian ini bertujuan untuk meningkatkan kelarutan piperin dengan memodifikasinya menjadi bentuk multikomponen kristal bersama kuersetin. Pembentukan multikomponen kristal piperin-kuersetin dilakukan menggunakan metode solvent drop grinding (SDG). Multikomponen dikarakterisasi dengan Differential Scanning Calorimetry (DSC), Powders X-Ray Diffraction (PXRD) dan spektroskopi FTIR.Evaluasi multikomponen dilakukan dengan uji kelarutan dan hasilnya dianalisis menggunakan KCKT.Termogram DSC menunjukkan tidak adanya puncak endotermik baru yang berbeda nyata dari kedua komponen. Pola difraksi sinar-X multikomponen kristal piperin-kuersetin menunjukkan difraktogram yang serupa dengan komponen penyusun, yang mengindikasikan tidak terbentuknya fase kokristalin. Karakterisasi menggunakan FTIR menunjukkan hampir tidak ada pergeseran puncak serapan gugus fungsi piperin pada multikomponen kristal. Uji kelarutan dilakukan terhadap senyawa tunggal piperin, campuran fisik piperin-kuersetin dan multikomponen piperin-kuersetin (1:1) yang dibuat dengan metode SDG. Campuran fisik dan multikomponen piperin-kuersetin yang dibuat dengan metode SDG meningkatkan kelarutan piperin sebesar 1,475 kali lipat dan 1,389 kali lipat jika dibandingkan dengan piperin murni.

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Sari, Yeni Novita, Erizal Zaini, and Friardi Ismed. "Peningkatan Laju Disolusi Piperine dengan Pembentukan Multikomponen Kristal Menggunakan Asam Nikotinat." Jurnal Sains Farmasi & Klinis 6, no. 2 (2019): 180. http://dx.doi.org/10.25077/jsfk.6.2.180-185.2019.

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Tujuan penelitian ini adalah untuk meningkatkan laju disolusi piperin dengan pembentukan multikomponen kristal piperin dan asam nikotinat (1:1) dengan metode pelarutan menggunakan pelarut etanol. Multikomponen kristal dikarakterisasi sifat padatannya dengan Difraksi sinar-X, analisa termal Differential Scaning Calorimetry (DSC), spektroskopi FT-IR, analisa mikroskopik Scanning Electron Microscopy (SEM), uji kelarutan dan profil laju disolusi menggunakan Aparatus USP 2. Dari penelitian serbuk multikomponen kristal piperin-asam nikotinat diperoleh hasil pola difraksi sinar-X menunjukkan puncak difraksi yang baru, analisa termal termogram DSC menunjukkan puncak endotermik pada 126,117 ºC, spektrum FTIR terdapat bilangan gelombang 3349,94 cm-1, analisa mikroskopik SEM menunjukkan sudah terbentuk agregat, uji kelarutan menunjukkan peningkatan 1,5 kali lipat dibandingkan piperin murni, profil laju disolusi piperin menunjukkan peningkatan secara signifikan dibandingkan piperin murni yaitu sekitar 2,5 kali lipat. Secara umum preparasi multikomponen kristal piperin-asam nikotinat dapat meningkatkan laju disolusi piperin

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Sutamihardja, RTM, Nia Yuliani, and Oktavio Rosani. "OPTIMASI SUHU PENGERINGAN DENGAN MENGGUNAKAN OVEN TERHADAP MUTU LADA HITAM DAN LADA PUTIH BUBUK." Jurnal Sains Natural 8, no. 2 (2018): 80. http://dx.doi.org/10.31938/jsn.v8i2.158.

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Optimization of Drying Temperature Using Oven on Quality of Black Pepper and White Pepper Powder Pepper (Piper Nigrum L) is an Indonesian spice plant widely used for export and import activity. The post-harvest process of pepper affected the quality, especially on the drying process. One of secondary metabolite compound is piperin. Piperin is an active substance of alkaloid group giving a distinctive spicy flavor to the pepper. Drying process by using the oven could improve the quality of pepper. The results showed that the optimum temperature for white pepper was 85° C for 20 minutes with the water content of 10.65%, total mold/yeast was 1 x 104 colony/g, and piperin content of 4.58%. For Black pepper, the optimum temperature was at 105° C for 20 minutes with the moisture content of 7.84%, total mold/yeast was 1.3 x 104 colony/g and piperin 5,01%.Keywords: White Pepper, Black Pepper, Piperin Content.ABSTRAK Lada (Piper Nigrum L) adalah tanaman rempah Indonesia yang banyak digunakan untuk ekspor dan impor. Proses pasca panen lada yang tidak maksimal menyebabkan kualitas menurun. Lada memiliki senyawa metabolit sekunder berupa piperin. Piperin adalah zat aktif golongan alkoloid yang memberikan cita rasa pedas khas pada lada. Pengeringan dengan menggunakan oven mampu meningkatkan mutu lada. Hasil penelitian menunjukan suhu optimum untuk pengovenan lada putih adalah 85°C selama 20 menit dengan kadar air sebesar 10,65 %, AKK 1 x 104 koloni/ g, dan kadar piperin 4,58 %. Lada hitam efektif pada suhu optimum 105°C selama 20 menit dengan kadar air sebesar 7,84 %, AKK 1,3 x 104 koloni / g dan kadar piperin 5,01 %.Kata kunci : Lada Putih, Lada Hitam, Kadar Piperin

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Kusumawati, Idha, Syailendra Mahatmaputra, Rohman Hadi, et al. "Aphrodisiac Activity of Ethanolic Extracts from the Fruits of Three Pepper Plants from Piperaceae Family." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 8, no. 2 (2021): 194. http://dx.doi.org/10.20473/jfiki.v8i22021.194-199.

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Background: Pepper plants belong to the Piperaceae family with many pharmacological activities. The fruits of these plants have been widely used traditionally for various therapies, one of which is an aphrodisiac. Objective: The purpose of this study was to determine the aphrodisiac activity of the fruits of three pepper plants, Piper nigrum, Piper retrofractum, and Piper cubeba to prove their traditional use. Methods: The level of piperin, the active compound of plants from the family Piperaceae, was also determined in the ethanolic extract of those three fruits of the pepper plant. The aphrodisiac activity was determined by counting the number of introducing and mounting mice. The acute toxicity test of the extract was carried out according to the OECD-423 guidelines. Results: The ethanolic extract of Piper nigrum fruits had the highest piperin concentration, while the ethanolic extract of Piper retrofractum fruits had the highest aphrodisiac activity, according to the findings. During the entire duration of the acute toxicity study, no signs of toxicity or mortality were discovered.Conclusion: This study proves that all fruits of three species of pepper plants exhibit aphrodisiac activity. Furthermore, this study also shows that not only piperin is responsible for the aphrodisiac effect.

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Bidarisugma, Berlian, Mar'atus Sholikhah, Sarah Usman Balbeid, and Anis Irmawati. "Piperin and piplartin as natural oral anticancer drug." Dental Journal (Majalah Kedokteran Gigi) 44, no. 4 (2011): 215. http://dx.doi.org/10.20473/j.djmkg.v44.i4.p215-219.

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Musthapa, Iqbal, and Gun Gun Gumilar. "Isolation of Piperin from The Fruit of Piper retrofractum." Indonesian Journal of Fundamental and Applied Chemistry 2, no. 1 (2017): 6–9. http://dx.doi.org/10.24845/ijfac.v2.i1.06.

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Shintawati, Shintawati. "Validasi Metode Analisis Piperin dalam Lada Hitam Secara Spektrofotometri." Majalah TEGI 10, no. 2 (2019): 53. http://dx.doi.org/10.46559/tegi.v10i2.4625.

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Rostiana, Otih, Dyah Manohara, Agus Ruhnayat, and NFN Wiratno. "Characteristics of Production and Quality of East Kalimantan Black Pepper." Buletin Penelitian Tanaman Rempah dan Obat 28, no. 2 (2018): 113. http://dx.doi.org/10.21082/bullittro.v28n2.2017.113-126.

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East Kalimantan is one of production center for white blackpepper, known as Samarinda White Pepper products. The variety developed in East Kalimantan is a local blackpepper variety that is not yet known for its characteristics. The research was conducted to observe the production and quality of local blackpepper in East Kalimantan, specifically in Kutai Kartanegara Regency which is the widest blackpepper development area in East Kalimantan. The observation was conducted for two years, at three locations of high yielding block (BPT) in Loa Janan and one non-BPT location in Muara Badak, as a local origin of local East Kalimantan blackpepper which is currently developing in Loa Janan. The environmental design used was a Randomized Block Design, with four trial sites, repeated six times in each location, using the same variety (local blackpepper). The average production for two years of observation reached 2.94 kg fresh berries/tree equivalent to 2.17 tons of white pepper/ha/year. However, the average of spikes containing pepper berries reached only 61.3% per panicle. Therefore, it requires intensive fertilization with appropriate dosage and fertilizer type to increase the expression of its potential genetic because local pepper of East Kalimantan bears fruit continuously throughout the year. Result of yield-quality analysis showed that local white pepper of East Kalimantan contained 11.23% oleoresin and 3.82% piperin, higher than Petaling 1 (10.66% and 3.03%, respectively). The superiority characteristics of local blackpepper of East Kalimantan is a distinctive aroma and spicy flavor, due to the high content of piperin and oleoresin.

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Kono, C., and T. Matsushima. "SUN-PO008: Effect of Resveratrol, Capsaicine and Piperin on Lipid Metabolism in 3T3L1 Cells." Clinical Nutrition 38 (September 2019): S61. http://dx.doi.org/10.1016/s0261-5614(19)32644-5.

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Untoro, Muhammad, Enny Fachriyah, and Dewi Kusrini. "Isolasi dan Identifikasi Senyawa Golongan Alkaloid dari Rimpang Lengkuas Merah (Alpinia purpurata)." Jurnal Kimia Sains dan Aplikasi 19, no. 2 (2016): 58–62. http://dx.doi.org/10.14710/jksa.19.2.58-62.

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Telah dilakukan penelitian tentang Isolasi dan Identifikasi Senyawa Golongan Alkaloid dari Rimpang Lengkuas Merah (Alpinia purpurata). Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi senyawa golongan alkaloid dari ekstrak rimpang lengkuas merah (Alpinia purpurata). Penapisan fitokimia simplisia kering diketahui bahwa terdapat senyawa golongan alkaloid, flavonoid, saponin, dan steroid. Hasil karakterisasi dengan menggunakan Spektrofotometer UV-Vis menghasilkan panjang gelombang maksimal pada 338 nm. Analisis menggunakan FTIR terdapat gugus C-N, C=O amida, C=C aromatik, C-O eter, dan C-H alifatik. Analisis menggunakan LC-MS diperoleh berat molekul sebesar 286,28 g/mol [M+H]+. Berdasarkan data-data dari hasil tersebut diduga dalam isolat murni mengandung senyawa piperin (C17H19NO3).

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Febriyanti, Alifia Putri, Siti Jazimah Iswarin, and Susanti Susanti. "PENETAPAN KADAR PIPERIN DALAM EKSTRAK BUAH LADA HITAM (Piper nigrum Linn.) MENGGUNAKAN LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC–MS/MS)." Jurnal Ilmiah Farmasi Farmasyifa 1, no. 2 (2018): 69–79. http://dx.doi.org/10.29313/jiff.v1i2.3160.

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The utilization of medicinal plants have started growing rapidly in the world, including in Indonesia, along with the thinking back to nature, one of the plants that are often used as a medicine is black pepper fruit (Piper nigrum Linn.). Piperine is a major compound and potent substances contained in black pepper fruit as antidiarrheal activity. The aim of this study was to determine levels of piperine in 96% ethanol extract of black pepper fruit. The extraction method used Soxhlet in 96% ethanol as solvent. Analysis of piperine using qualitative analysis by thin layer chromatography (TLC) produces yellow stain after being sprayed by dragendorf and dark blue on observation Uv-Vis 365 nm with Rf extract value 0.49 and Rf piperine value 0.5. Quantitative analysis using LC – MS produces piperine levels at 26%. Before quantitative analysis, validation method needs to be done with the parameters, among others: linearity have regression equation y = has 1,981,691.1333x + 561,445.0000 and correlation coefficient (R2) of 0.9973, LOD and LOQ at 0.14 and 0.44 ppm, accuracy value (% recovery) between 95.90 – 100.77%, precision value (% KV) between 0.02 – 1.84%, and selectivity (RT) between 2.47 – 2.49. The results of the validation parameters are eligible so that piperine levels were obtained by LC – MS declared accurate, specific, and precise.

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Nurismi, Eldya, Henni Rosaini, and dan Maria Dona Octavia. "Review: Effect of Different Methods on the Multicomponents Crystal Formation from Medicinal Natural Ingredient Compounds." International Journal of Pharmaceutical Sciences and Medicine 6, no. 5 (2021): 32–39. http://dx.doi.org/10.47760/ijpsm.2021.v06i05.004.

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Solubility is an important parameter for the bioavailability of drugs that are difficult to dissolve. Natural compounds that are included in class II in the Biopharmaceutics Classification System (BCS) are Apigenin, Quercetin, Genistein, Curcumin, and Piperin. These drugs have low solubility in water and high permeability so that they affect the dissolution rate and as well as their bioavailability, to increase the solubility they are made with multicomponent crystals. This review aims to provide information on the method of making crystal multicomponent to increase the solubility and dissolution rate of BCS II drugs. Several methods that can be used in multicomponent are solvent drop grinding, solvent evaporation, assisted grinding, and slurry. The results showed that multicomponent crystals using several methods could increase the solubility and dissolution rates.

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Sampepana, Eldha, Adhitya Rinaldi, Titik Nurwidayati, and Suroto Hadi Saputro. "Kadar Air, Piperin dan Minyak Atsiri Lada Produk UKM Samboja, UKM Bontang dan di Pasaran Samarinda." Jurnal Riset Teknologi Industri 14, no. 2 (2020): 275. http://dx.doi.org/10.26578/jrti.v14i2.6672.

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Hielscher, J., A.-S. Lemmes, B. von Holtum, et al. "Nachweis und quantitative Bestimmung von Piperin in Cayennepfeffer, Chillipulver und Rosenpaprika - Sind Verunreinigungen mit echtem Pfeffer technisch unvermeidbar?" Lebensmittelchemie 70, no. 4 (2016): 92–98. http://dx.doi.org/10.1002/lemi.201690028.

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Hernani, NFN, Tatang Hidayat, and NFN Risfaheri. "EVALUASI MUTU LADA PUTIH BUBUK YANG DIPERDAGANGKAN DI PASAR TRADISIONAL DAN MODERN DI BOGOR DAN JAKARTA." Jurnal Penelitian Pascapanen Pertanian 17, no. 3 (2021): 126. http://dx.doi.org/10.21082/jpasca.v17n3.2020.126-133.

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Lada putih bubuk mempunyai sifat sangat higroskopis, sehingga mudah mengalami kerusakan, baik fisik, kimia ataupun mikrobiologis. Tujuan dari penelitian adalah menentukan mutu lada putih bubuk, baik secara fisik, kimia dan mikrobiologi dari pasar tradisional dan modern di wilayah Bogor dan Jakarta serta mendapatkan informasi awal/indikasi adanya pencampuran bahan lain pada lada putih bubuk. Metodologi penelitian terdiri atas beberapa tahapan, yaitu metode pengambilan sampel dilakukan secara acak sederhana (simple random sampling), dari pasar tradisional yang dijual secara curah, dan pasar modern yang dikemas dalam botol plastik, masing-masing 3 lokasi dan 3 ulangan. Untuk masing-masing sampel yang diambil dari pasar tradisional dan modern adalah 300 g. Pengujian fisiko-kimia sesuai dengan metode yang dikeluarkan oleh IPC (International Pepper Community), yaitu kadar air, abu, abu tak larut asam, minyak atsiri, piperin dan logam timbal (Pb). Untuk uji mikrobiologis terdiri dari TPC (Total Plate Count), kapang, jamur, Salmonella dan Escheria coli. Selain itu, dilakukanan analisis SEM (Scanning Electrone Microscope) untuk melihat profil morfologi permukaan. Hasil penelitian menunjukkan bahwa untuk kadar air, abu, minyak atsiri masih memenuhi kriteria SNI 01 3717 1995, kecuali kadar abu yang tidak larut asam dan kadar piperin. Cemaran mikrobiologi (TPC, kapang dan jamur) memenuhi kriteria, kecuali E. coli dan jamur pada sampel dari pasar tradisional Bogor. Salmonella memenuhi kriteria SNI untuk semua sampel, yaitu negatif. Cemaran logam berat (Pb) masih memenuhi ketentuan kriteria SNI. Deteksi pencampuran lada putih bubuk dengan bahan lain menggunakan metode kombinasi sifat fisiko-kimia dan SEM baru bisa mendeteksi adanya indikasi pencampuran, dan belum bisa menentukan jenis bahan percampurnya. Evaluation Of Quality of White Pepper Powder on Trade in Traditional and Modern Markets in Bogor and Jakarta.White pepper powder has very hygroscopic properties, so it is easily damaged, physically, chemically, or microbiologically. The purpose of this study was to determine the quality of white pepper powder, physically, chemically, and microbiologically from the traditional and modern markets of Bogor and Jakarta and to obtain information of mixing white pepper powder using other ingredients. The research methodology consists of several stages, namely sampling from traditional markets that are sold in bulk, and modern markets, which are packaged in plastic bottles; the sample has taken from 3 locations and 3 replications. For each sample taken from traditional and modern markets was 300 g. The physico-chemical tested according to the methods issued by the IPC, especially for moisture, ash content, acid insoluble ash, essential oil, piperine and timbal (Pb). The microbiological was tested, including TPC, mold, fungus, Salmonella and Escheria coli. In addition, an SEM analysis was performed to see the surface morphology profile. The results showed that moisture, ash content, ash insoluble in acid, volatile oil still meets the criteria of Indonesian National Standard, except for ash insoluble in acid and piperine content. Microbiological contamination fulfilled SNI criteria except E. coli and mold in samples from PT Bogor. Salmonella was fulfilled SNI criteria for all samples, which are given negative. Heavy metal (Pb) still fulfils the requirement in SNI criteria. Detection of mixing white pepper powder with other ingredients using a combination of physico-chemical properties and SEM can detect the indication of mixing and has not been able to determine the type of mixing material.

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Chopra, Bhawna, Ashwani K. Dhingra, and Deo N. Prasad. "Modification in the Natural Bioactive Molecule: Piperine; A Continuing Source for the Drug Development." Current Bioactive Compounds 16, no. 6 (2020): 714–25. http://dx.doi.org/10.2174/1573407215666190318125023.

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Background: Piperine, a bioactive alkaloid was a well-known component which was used traditionally to treat a variety of disorders. Objective: The present review is to discuss the modified piperine or piperic acid analogs or its derivatives to explore the potential of piperine. Piperine or piperic acid had potentials as antibacterial, antitumor, antioxidant, anti-inflammatory, antifungal, immunomodulatory and many more for drug development. So modification in natural molecule piperine generates numerous derivatives or analogues which may be found beneficial in drug development. Methods: A literature survey has been carried out to determine the real potential of piperine and its modified analogs. Results: It has been scrutinized that piperine and its derivatives possess valuable components with good therapeutic potential. Conclusion: Thus, this review aims to provide knowledge as well as to explore the excellent potential of piperine, piperic acid, piperine derived compounds/ analogs which may further, after performing toxicity studies, and other parameters, be helpful in the design and development of novel drug candidates against numerous disease conditions and thus it paves way for further work in exploring the potential to treat the patients with obesity and skin related disorders.

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Saenong, M. Sudjak. "Tumbuhan Indonesia Potensial sebagai Insektisida Nabati untuk Mengendalikan Hama Kumbang Bubuk Jagung (Sitophilus spp.)." Jurnal Penelitian dan Pengembangan Pertanian 35, no. 3 (2017): 131. http://dx.doi.org/10.21082/jp3.v35n3.2016.p131-142.

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Indonesia mempunyai keragaman flora yang sangat besar. Lebih dari 400 ribu jenis tumbuhan telah teridentifikasi bahan kimianya dan 10 ribu di antaranya mengandung metabolit sekunder yang potensial sebagai bahan baku pestisida nabati. Hasil-hasil penelitian menunjukkan senyawa metabolit sekunder dapat mengendalikan populasi serangga hama. Sifat dan mekanisme kerja bahan nabati tersebut dalam melindungi tanaman dapat sebagai antifitopatogenik (antibiotik pertanian), fitotoksik atau mengatur pertumbuhan tanaman (fitotoksin, hormon, dan sejenisnya), dan bahan aktif terhadap serangga (hormon serangga, feromon, antifidan, repelen, atraktan, dan insektisida). Tulisan ini membahas pemanfaatan insektisida nabati dalam pengendalian hama kumbang bubuk (Sitophilus spp.) pada jagung selama penyimpanan. Selain pada jagung, hama ini juga merusak komoditas tanaman pangan penting lainnya seperti padi, sorgum, dan gandum. Untuk mengatasi hama tersebut, pemanfaatan insektisida nabati dapat menjadi salah satu pilihan. Hasil penelitian menunjukkan bahwa kandungan metabolit sekunder dapat menekan perkembangan populasi serangga hama. Kandungan metabolit sekunder pada tanaman antara lain adalah senyawa atsiri seperti minyak atsiri, sitral, geraniol, tanin, piperin, asetogenin, azadirahtin, saponin, asaron, akoragermakron, akolamonin, isoakolamin, kalameon, kalamediol, alfamirin, kaemfasterol, salanin, nimbin, nimbidin, asetogenin, dan beberapa kelompok asam seperti asam sianida, asam oleanolat, dan asam galoyonat. Komponen alkaloid hampir terdapat dalam semua tanaman yang diuji, selain flavonoid lainnya yang berdampak langsung terhadap kehidupan serangga hama.

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., Junairiah, Dewi Amelia Sofiana, Yosephine Sri Wulan Manuhara, and Surahmaida . "Induksi Kalus Piper retrofractum Vahl. dengan Zat Pengatur Tumbuh Auksin dan Sitokinin." Journal of Pharmacy and Science 3, no. 2 (2018): 41–46. http://dx.doi.org/10.53342/pharmasci.v3i2.116.

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ABSTRAK Cabai Jawa (Piper retrofractum Vahl.) dikenal sebagai tanaman hias dan tanaman obat. Metabolit sekunder pada tanaman ini adalah piperin, saponin, kavisin dan minyak atsiri. Metabolit sekunder tersebut dapat diisolasi dari bahan tanaman atau kalus hasil kultur jaringan tanaman. Pada metode kultur jaringan tanaman untuk menginduksi kalus diperlukan media dengan konsentrasi zat pengatur tumbuh yang tepat untuk mendapatkan hasil yang optimal. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi konsentrasi zat pengatur tumbuh Naphthalene Acetic Acid (NAA) dan 6-Benzyl Amino Purin (BAP) yang paling baik untuk induksi kalus P. retrofractum. Jenis penelitian ini adalah eksperimental laboratoris. Penelitian menggunakan rancangan acak lengkap (RAL) dengan 17 perlakuan yang terdiri atas 16 perlakuan kombinasi zat pengatur tumbuh dan 1 perlakuan kontrol, Setiap perlakuan terdiri atas 6 ulangan. Eksplan daun P. retrofractum ditumbuhkan pada medium Murashige dan Skoog padat ditambah dengan zat pengatur tumbuh dengan konsentrasi masing-masing 0; 0,5; 1; 1,5; 2 mg/L. Data yang diperoleh berupa data kuantitatif dan kualitatif. Data kuantitatif meliputi lama waktu induksi kalus, persentase eksplan membentuk kalus, berat segar kalus dan berat kering kalus, dianalisis secara statistik dengan SPSS. Data kualitatif meliputi warna dan tekstur kalus. Hasil penelitian menunjukkan bahwa zat pengatur tumbuh NAA dan BAP berpengaruh terhadap pertumbuhan eksplan daun P. retrofractum. Penambahan kombinasi konsentrasi NAA 0,5 mg/L dan BAP 0,5 mg/L menunjukkan respon terbentuknya kalus paling cepat yaitu 11,5 hari. Penambahan kombinasi konsentrasi NAA 1 mg/L dan BAP 0,5 mg/L menghasilkan berat segar terbaik yaitu 70,6 mg, sedangkan pada kombinasi konsentrasi NAA 1 mg/L dan BAP 2 mg/L menghasilkan berat kering terbaik yaitu 18 mg. Warna kalus adalah putih dan putih kecokelatan dengan tekstur friabel dan kompak.Kata kunci: BAP, induksi kalus, NAA, Piper retrofractum Vahl.ABSTRACT Chili Java (Piper retrofractum Vahl.) is known as ornamental plants and medicinal plants. Secondary metabolites in this plant are piperin, saponin, kavisin and essential oils. Secondary metabolites can be isolated from plant material or callus from plant tissue culture. In plant tissue culture method to induce callus required media with the growth regulator concentration to get optimal result. The aim of this research is to know the effect of the combination of growth regulator of Naphthalene Acetic Acid (NAA) and 6-Benzyl Amino Purin (BAP) which is best for the induction of P. retrofractum callus. The type of this study was laboratory experimental. The study used a complete randomized design (RAL) with 17 treatments consisting of 16 treatment combinations of growth regulators and 1 control treatment. Each treatment consisted of 6 replications. P. retrofractum leaf eksplan grown on Murashige and Skoog solid medium coupled with growth regulator substances with respective concentrations of 0; 0.5; 1; 1.5; 2 mg / L. The data obtained in the form of quantitative and qualitative data. Quantitative data include duration of callus induction, percentage of callus form explants, fresh callus weight and dry weight of callus, analyzed statistically with SPSS. Qualitative data include callus color and texture. The results showed that NAA and BAP growth regulator effect on growth of P. retrofractum leaf eksplan. The addition of a combination of NAA concentration of 0.5 mg / L and BAP 0.5 mg / L showed the fastest callus formation response of 11.5 days. The combination of NAA concentration of 1 mg / L and BAP 0,5 mg / L resulted in the best fresh weight of 70.6 mg, while in combination NAA concentration 1 mg / L and BAP 2 mg / L yielded the best dry weight of 18 mg. Callus color is white and white with a friable and compact texture.Keywords:BAP, callus induction, NAA, Piper retrofractum Vahl

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Indriati, Gusti, and Samsudin Samsudin. "Aktivitas Insektisida Ekstrak Piperaceae terhadap Helopeltis antonii pada Kakao." Jurnal Tanaman Industri dan Penyegar 1, no. 1 (2014): 7. http://dx.doi.org/10.21082/jtidp.v1n1.2014.p7-14.

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Helopeltis antonii merupakan hama pucuk dan buah kakao. Pengendalian menggunakan insektisida kimia cukup efektif untuk mengendalikan hama ini, akan tetapi dapat menimbulkan efek negatif pada lingkungan. Oleh sebab itu, pengendalian menggunakan insektisida yang berasal dari tumbuhan dapat menjadi alternatif yang lebih aman. Penelitian bertujuan mengevaluasi aktivitas insektisida dari ekstrak empat jenis tumbuhan dari famili Piperaceae, yaitu Piper aduncum, P. retrofractum, P. cubeba, dan P. sarmentosum, terhadap H. antonii pada kakao. Penelitian dilaksanakan di Laboratorium Proteksi Tanaman Balai Penelitian Tanaman Industri dan Penyegar (Balittri) Sukabumi pada bulan Januari sampai November 2013. Setiap jenis ekstrak diuji pada taraf konsentrasi 1%; 0,5%; 0,25%; 0,125%; 0,062%; dan kontrol (campuran aseton, methanol, dan Tween-80 dengan perbandingan 5:5:2) sebanyak 1,2%. Masing-masing perlakuan diulang sebanyak 3 kali. Uji toksisitas menggunakan imago H. antonii dengan metode penyemprotan serangga uji. Hasil penelitian menunjukkan bahwa ekstrak etil asetat buah P. retrofractum pada konsentrasi 0,25% menyebabkan kematian imago sebesar 83,33% pada 120 jam setelah perlakuan (JSP), sedangkan ekstrak etil asetat P. aduncum, P. cubeba, dan P. sarmentosum pada konsentrasi dan waktu yang sama hanya menyebabkan kematian berturut-turut 33,33%; 20%; dan 13,33%. Aktivitas insektisida dari ekstrak etil asetat buah P. retrofractum paling kuat terhadap imago H. antonii karena mengandung senyawa piperin, yaitu 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl] piperidine; (E,E) 1,3-benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperidine; dan 3-benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine. LC95 ekstrak etil asetat buah P. retrofractum terhadap imago H. antonii dibawah 0,5% sehingga paling berpotensi untuk dikembangkan menjadi insektisida nabati pengendali hama tersebut pada kakao.Kata Kunci: Helopeltis antonii, Piperaceae, aktifitas insektisida, kakaoHelopeltis antonii is one of cocoa pest that attacks the shoot and pods. The insecticides can control this pest effectivelly, but could cause negative effects on the environment. Therefore, botanical insecticide could be a safer alternative for environment. The objective of this study was to evaluate the insecticidal activity of Piperaceae extracts: Piper aduncum, P. retrofractum, P. cubeba, and P. sarmentosum against H. antonii on cocoa. The experiment was conducted at the Plant Protection Laboratory of Indonesian Industrial and Beverage Crops Research Institute (IIBCRI) Sukabumi, from January to November 2013. Those extracts were tested at 1%; 0.5%; 0.25%; 0.125%; 0.062% concentration level, respectively; and control (a mixture of acetone, methanol and Tween-80 with a ratio of 5:5:2) at 1.2% concentration level. All of treatments were repeated 3 times. The toxicity assessment was use of spraying method onto imago of H.antonii. The results showed that the ethyl acetate extract of P. retrofractum at 0.25% concentration caused 83.33% mortality of H. antonii imago at 120 hours after treatment (HAT), while the ethyl acetate extract of P. aduncum, P. cubeba, and P. Sarmentosum at the same time and concentration only leads to 33.33%; 20%; and 13.33% mortality, respectively. The insecticidal activity of P. retrofractum ethyl acetate extract was strongest against the imago of H. antonii because it contains piperine: 1-[(2E, 4E)-5 (1,3-benzodioxol-5-yl)-2,4-pentadienoyl] piperidine; (E,E) 1,3-benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperidine; and 3-benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine. LC95 of P. retrofractum ethyl acetate extract against imago of H. antonii was below 0.5%, so it become the most potential to develop into botanical insecticide.

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Jin, Zhehao, Juraithip Wungsintaweekul, Sang-Hoon Kim, et al. "4-Coumarate:coenzyme A ligase isoform 3 from Piper nigrum (Pn4CL3) catalyzes the CoA thioester formation of 3,4-methylenedioxycinnamic and piperic acids." Biochemical Journal 477, no. 1 (2020): 61–74. http://dx.doi.org/10.1042/bcj20190527.

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Black pepper, dried green fruit of Piper nigrum L., is a household spice most popular in the world. Piperine, the pungency compound of black pepper, is proposed to partially arise from phenylpropanoid pathway. In the biosynthesis of piperine, 4-coumarate:CoA ligase (4CLs) must play a pivotal role in activating intermediate acids to corresponding CoA thioesters to serve as substrates. Based on transcriptome data, we isolated three P. nigrum 4CL isoforms (Pn4CL1, -2, and -3) from unripe peppercorn. These Pn4CLs were expressed in E. coli for in vitro enzyme assay with putative substrates, namely cinnamic, coumaric, ferulic, piperonylic, 3,4-methylenedioxycinnamic (3,4-MDCA), and piperic acids. Phylogenetic analysis and substrate usage study indicated that Pn4CL1, active towards coumaric and ferulic acids, belongs to class I 4CL for lignin synthesis. Pn4CL2 was a typical cinnamate-specific coumarate:CoA ligase-like (CLL) protein. The Pn4CL3, as class II enzyme, exhibited general 4CL activity towards coumaric and ferulic acids. However, Pn4CL3 was also active towards piperonylic acid, 3,4-MDCA, and piperic acid. Pn4CL3 possessed ∼2.6 times higher catalytic efficiency (kcat/KM) towards 3,4-MDCA and piperic acid than towards coumaric and ferulic acids, suggesting its specific role in piperine biosynthesis. Different substrate preference among the Pn4CL isoforms can be explained by 3-dimensional protein structure modeling, which demonstrated natural variants in amino acid residues of binding pocket to accommodate different substrates. Quantitative PCR analysis of these isoforms indicated that Pn4CL1 transcript level was highest in the roots whereas Pn4CL2 in the fruits and Pn4CL3 in the leaves.

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Rong, A., Narisu Bao, Zhaorigetu Sun, Gereltu Borjihan, Yanjiang Qiao, and Zhuang Jin. "Synthesis and Antihyperlipidemic Activity of Piperic Acid Derivatives." Natural Product Communications 10, no. 2 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000218.

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A series of piperic acid derivatives were designed and synthesized from piperine/ piperlonguminine, and their antihyperlipidemic activities evaluated in diet-induced hyperlipidemic rats with respect to simvastatin. Two promising analogues 3 and 10 were discovered and their antihyperlipidemic activities were comparable to or better than those of simvastatin.

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PRIYA, V. SHANMUGA, C. UMA RANI та S. VELRANI. "SYNERGISTIC EFFECT OF HALIDE IONS ON THE CORROSION INHIBITION OF MILD STEEL IN SULPHURIC ACID USING METHYL, N-METHYL ETHYL AND ETHYL SUBSTITUTED γ-2,c-6-DIPHENYL PIPERIDIN-4-ONE SEMICARBAZONES". Surface Review and Letters 25, № 02 (2018): 1850050. http://dx.doi.org/10.1142/s0218625x18500506.

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The synergistic effect of halide ions such as KCl, KBr and KI on the corrosion inhibition of mild steel in 1 N sulphuric acid by [Formula: see text]-2,c-6-diphenyl-t-3-methyl piperdin-4-ones with semicarbazone (01[Formula: see text]SC), [Formula: see text]-2,c-6-diphenyl-N-methyl-t-3-ethyl piperdin-4-ones with semicarbazone (02[Formula: see text]SC) and 2,6-diphenyl-t-3-ethyl piperdin-4-one with semicarbazone (03[Formula: see text]SC) has been examined by weight loss method, potentiodynamic polarization measurements and electrochemical AC impedance spectroscopy. Results show that substituted [Formula: see text]-2,c-6-diphenyl piperidin-4-ones with semicarbazone act as the perfect corrosion inhibitors and their inhibition efficiency increases with the addition of halide ions. The inhibitor (01[Formula: see text]SC) shows the inhibition efficiency of 78.28% (0.2[Formula: see text]mM) by using a weight loss method. The influence of I[Formula: see text], Br[Formula: see text] and Cl[Formula: see text] anions raises the inhibition efficiency of the substituted 2,6-diphenyl piperidin-4-ones with semicarbazone due to the synergistic effect. The synergistic effect of halide ions was formed in the following order: KI [Formula: see text] KBr [Formula: see text] KCl.

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Schnabel, Arianne, Fernando Cotinguiba, Benedikt Athmer, and Thomas Vogt. "Piper nigrum CYP719A37 Catalyzes the Decisive Methylenedioxy Bridge Formation in Piperine Biosynthesis." Plants 10, no. 1 (2021): 128. http://dx.doi.org/10.3390/plants10010128.

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Black pepper (Piper nigrum) is among the world’s most popular spices. Its pungent principle, piperine, has already been identified 200 years ago, yet the biosynthesis of piperine in black pepper remains largely enigmatic. In this report we analyzed the characteristic methylenedioxy bridge formation of the aromatic part of piperine by a combination of RNA-sequencing, functional expression in yeast, and LC-MS based analysis of substrate and product profiles. We identified a single cytochrome P450 transcript, specifically expressed in black pepper immature fruits. The corresponding gene was functionally expressed in yeast (Saccharomyces cerevisiae) and characterized for substrate specificity with a series of putative aromatic precursors with an aromatic vanilloid structure. Methylenedioxy bridge formation was only detected when feruperic acid (5-(4-hydroxy-3-methoxyphenyl)-2,4-pentadienoic acid) was used as a substrate, and the corresponding product was identified as piperic acid. Two alternative precursors, ferulic acid and feruperine, were not accepted. Our data provide experimental evidence that formation of the piperine methylenedioxy bridge takes place in young black pepper fruits after a currently hypothetical chain elongation of ferulic acid and before the formation of the amide bond. The partially characterized enzyme was classified as CYP719A37 and is discussed in terms of specificity, storage, and phylogenetic origin of CYP719 catalyzed reactions in magnoliids and eudicots.

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Zarai, Zied, Emna Boujelbene, Nadia Ben Salem, Youssef Gargouri, and Adel Sayari. "Antioxidant and antimicrobial activities of various solvent extracts, piperine and piperic acid from Piper nigrum." LWT - Food Science and Technology 50, no. 2 (2013): 634–41. http://dx.doi.org/10.1016/j.lwt.2012.07.036.

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Sivashanmugam, Arthi, and Sivan Velmathi. "Synthesis, in vitro and in silico anti‐bacterial analysis of piperine and piperic ester analogues." Chemical Biology & Drug Design 98, no. 1 (2021): 19–29. http://dx.doi.org/10.1111/cbdd.13842.

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Ding, Ke Qin, Li Qi Yi, and Cai Fu Qian. "The Deformation Detection Method for the Buried Pipeline Based on Distributed Fiber Optic Sensor." Applied Mechanics and Materials 330 (June 2013): 444–49. http://dx.doi.org/10.4028/www.scientific.net/amm.330.444.

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The deformation of the long-distance pipeline often happen due to the Soil collapse, gulch and the settlement of the foundation etc. The large deformation is easy to cause the fracture of the long-distance pipeline. Hence, the deformation detection is of very important to the pipeline safety. In this paper, a method for deformation calculation of the long-distance pipeline is presented based on the relation expression brtween the deformation and the strain of the long-distance pipelien. Through the measured strain, the deformation is easy to be calculated. The strains can be obtained through the FBG sensors or distributed fiber optic sensors. The deformation detection method proposed in the papaer provides the basis of the long-distance pipeline risk management.

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Huang, Jing, Tao Zhang, Shengli Han, Jingjing Cao, Qinhua Chen, and Sicen Wang. "The inhibitory effect of piperine from Fructus piperis extract on the degranulation of RBL-2H3 cells." Fitoterapia 99 (December 2014): 218–26. http://dx.doi.org/10.1016/j.fitote.2014.10.001.

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Noumo, Prosper Gopdjim, Donatien Njomo, Kevin Zepang Nana, and Leonard Ribot Chuisseu Nguewo. "Numerical Simulation of the Minimum Insulation Thickness to Thermally Design a Subsea Pipeline Carrying an Oil and Gas Flow." International Journal of Heat and Technology 39, no. 3 (2021): 763–74. http://dx.doi.org/10.18280/ijht.390310.

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This paper considered an existing subsea pipeline transporting an oil and gas flow, and proposed to find the best thermal insulating material and the required thickness of insulation necessary to meet an output temperature of 40℃ and a pressure of 2.4MPa so as to avoid flow assurance issues. MATLAB and PIPESIM software were employed to run the simulations of the temperature and pressure profiles along the considered pipeline. Data used for the simulations were obtained from open literature. Results obtained from our simulations in MATLAB are validated using PIPESIM software, measured values and prediction model from literature. The temperature model was then used to thermally design an insulation thickness for the 50 km long pipeline using three insulating materials which are: black aerogel, polyurethane and calcium silicate. Results from the analysis showed that the black Aerogel material with a critical thickness of 10.16 cm is most effective to satisfy the criterion design. The effect of the selected insulating material was also investigated on the phase envelop. Results shows that for proper insulation thickness the flowing fluid temperature can be maintained at a temperature above which no flow assurance issues can be observed.

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Schnabel, Arianne, Fernando Cotinguiba, Benedikt Athmer, et al. "A piperic acid CoA ligase produces a putative precursor of piperine, the pungent principle from black pepper fruits." Plant Journal 102, no. 3 (2020): 569–81. http://dx.doi.org/10.1111/tpj.14652.

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Rentala, Satyanarayana, VSPK Sanakara Aditya J, Naresh Kumar L, Taraka Ramji, and Aruna Lakshmi Komarraju. "Docking Studies of Piperine with some Drug Transporters." International Journal of Scientific Research 1, no. 5 (2012): 10–11. http://dx.doi.org/10.15373/22778179/oct2012/3.

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Marfo, S. A., P. Opoku Appau, J. Acquah, and E. M. Amarfio. "Flow Assurance in Subsea Pipeline Design - A Case Study of Ghana’s Jubilee and TEN Fields." Ghana Mining Journal 19, no. 1 (2019): 72–85. http://dx.doi.org/10.4314/gm.v19i1.9.

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The increasing exploration and production activities in the offshore Cape Three Point Blocks of Ghana have led to the discovery and development of gas condensate fields in addition to the oil fields which produce significant amount of condensate gas. These discoveries require pipelines to transport the fluids avoiding hydrates and wax formation. This paper focuses on subsea pipeline design using Pipesim software that addresses flow assurance problems associated with transporting condensate gas from the Jubilee and TEN Fields to the Atuabo Gas Processing Plant. It also considered an alternate design that eliminates the need for capacity increase of flowlines for the futuristic highest projected flow rates in 2030. The design comprises of two risers and two flowlines. Hydrate formation temperature was determined to be 72.5 ˚F at a pressure of 3 000 psig. The insulation thickness for flowlines 1 and 2 were determined to be 1.5 in. and 2 in. respectively. The pipe size for flowlines 1 and 2 were determined to be 12 in. and 14 in. respectively. The maximum designed flow rate was determined to be 150 MMSCFD. To meet the highest projected flow rate of 700 MMSCFD in the year 2030 at the processing plant, a 16 in. ID pipeline of 44 km length was placed parallel to the 12 in. ID flowline 1. This parallel pipeline increased the designed flow rate by approximately 4.7 times (705 MMSCFD). The alternate design employs 18 in. and 20 in. ID pipes for flowlines 1 and 2 respectively. Keywords: Condensate Gas; Flowline; Flow Assurance; Hydrate; Pipesim

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Mgbeahuruike, Eunice, Pia Fyhrquist, Heikki Vuorela, Riitta Julkunen-Tiitto, and Yvonne Holm. "Alkaloid-Rich Crude Extracts, Fractions and Piperamide Alkaloids of Piper guineense Possess Promising Antibacterial Effects." Antibiotics 7, no. 4 (2018): 98. http://dx.doi.org/10.3390/antibiotics7040098.

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Piper guineense is a food and medicinal plant commonly used to treat infectious diseases in West-African traditional medicine. In a bid to identify new antibacterial compounds due to bacterial resistance to antibiotics, twelve extracts of P. guineense fruits and leaves, obtained by sequential extraction, as well as the piperine and piperlongumine commercial compounds were evaluated for antibacterial activity against human pathogenic bacteria. HPLC-DAD and UHPLC/Q-TOF MS analysis were conducted to characterize and identify the compounds present in the extracts with promising antibacterial activity. The extracts, with the exception of the hot water decoctions and macerations, contained piperamide alkaloids as their main constituents. Piperine, dihydropiperine, piperylin, dihydropiperylin or piperlonguminine, dihydropiperlonguminine, wisanine, dihydrowisanine and derivatives of piperine and piperidine were identified in a hexane extract of the leaf. In addition, some new piperamide alkaloids were identified, such as a piperine and a piperidine alkaloid derivative and two unknown piperamide alkaloids. To the best of our knowledge, there are no piperamides reported in the literature with similar UVλ absorption maxima and masses. A piperamide alkaloid-rich hexane leaf extract recorded the lowest MIC of 19 µg/mL against Sarcina sp. and gave promising growth inhibitory effects against S. aureus and E. aerogenes as well, inhibiting the growth of both bacteria with a MIC of 78 µg/mL. Moreover, this is the first report of the antibacterial activity of P. guineense extracts against Sarcina sp. and E. aerogenes. Marked growth inhibition was also obtained for chloroform extracts of the leaves and fruits against P. aeruginosa with a MIC value of 78 µg/mL. Piperine and piperlongumine were active against E. aerogenes, S. aureus, E. coli, S. enterica, P. mirabilis and B. cereus with MIC values ranging from 39–1250 µg/mL. Notably, the water extracts, which were almost devoid of piperamide alkaloids, were not active against the bacterial strains. Our results demonstrate that P. guineense contains antibacterial alkaloids that could be relevant for the discovery of new natural antibiotics.

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Yadav, Pradeep, and Y. C. Joshi. "Synthesis and Spectral Study of Novel Norfloxacin Derivatives." E-Journal of Chemistry 5, s2 (2008): 1154–58. http://dx.doi.org/10.1155/2008/357073.

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Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with variousβ-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were established on the basis of spectral studies viz. IR,1H NMRetc.

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Gorokhova, N. V. "FRAME ANALYSIS OF ENGLISH TERM PIPELINE." Учёные записки Петрозаводского государственного университета 173, no. 4 (2018): 45–48. http://dx.doi.org/10.15393/uchz.art.2018.147.

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Šilhánková, Alexandra, Karel Šindelář, Karel Dobrovský, Ivan Krejčí, Jarmila Hodková, and Zdeněk Polívka. "Synthesis of New L-Proline Amides with Anticonvulsive Effect." Collection of Czechoslovak Chemical Communications 61, no. 7 (1996): 1085–92. http://dx.doi.org/10.1135/cccc19961085.

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Series of heterocyclic L-proline amides were prepared from BOC-L-proline and heterocyclic amines (mostly substituted piperazines and morpholines) via active ester with hydroxysuccinimide. 4-(4-Fluorobenzoyl)piperidine afforded L-proline 4-(4-(4-(4-fluorobenzoyl)piperidin-1-yl)benzoyl)piperidine (7b) simultaneously with expected L-proline 4-(4-fluorobenzoyl)piperidide (7a). D-Proline N-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)amide (2) was prepared starting from D-proline. The amides were tested by methods of biochemical and behavioural pharmacology.

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Plavsic, Dragana, Marija Skrinjar, Djordje Psodorov, et al. "Chemical structure and antifungal activity of mint essential oil components." Journal of the Serbian Chemical Society 85, no. 9 (2020): 1149–61. http://dx.doi.org/10.2298/jsc191210017p.

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The objective of this research was to determine chemical composition and to evaluate the antifungal activity of essential oil of Mentha piperita. By the application of GC/MS analysis of essential mint oil, 27 components were identified. The major components were menthol (39.9 %), menton (23.51 %), menthyl acetate (7.29 %), 1.8-cineol (5.96 %), isomenton (5.24 %), isomenthol (3.17 %), trans-caryophyllene (2.88 %), limonene (2.14 %), pulegon (1.38 %), beta-pinene (1.14 %) and piperiton (1.03 %). The quantitative structure? retention relationship (QSRR) was employed to predict the retention time (RT) of Mentha piperita essential oil compounds obtained in GC/MS analysis, using twelve molecular descriptors selected by genetic algorithm. The selected descriptors were used, as inputs of an artificial neural network, to build an RT predictive QSRR model. The coefficient of determination was 0.983, during training cycle, indicating that this model could be used for prediction of RT values for essential oil compounds in Mentha piperita essential oil extracts. Essential oil of Mentha piperita showed antifungal activity on all tested isolates in the minimal inhibitory concentration range of 0.2?1.7 ?l/ml and a minimal fungicidal concentration (MFC) range of 1.7?454.5 ?l/ml. The most powerful antifungal activity of mint was observed in C. cladosporioides of MFC value 1.7 ?l/ml. P. aurantiogriseum showed the lowest sensitivity of MFC value 454.5 ?l/ml.

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Chopra, Bhawna, Ashwani K. Dhingra, Deo N. Prasad, Sakshi Bhardwaj, and Sonal Dubey. "Synthesis and In Silico Molecular Docking Studies on Substituted Piperic Acid Derivatives as Inhibitors of Bacterial DNA Gyrase." Current Computer-Aided Drug Design 16, no. 3 (2020): 281–94. http://dx.doi.org/10.2174/1573409915666190710092032.

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Background: Piperine or piperic acid was isolated from fruits of Piper nigrum and had been reported as pharmacological valuable bioactive constituents. Keeping in view, a series of piperic acid-based N heterocyclic’s derivatives were synthesized and evaluated for antibacterial activity. All these prepared ligands were docked to study the molecular interactions and binding affinities against the protein PDB ID: 5 CDP. Objective: To meet the real need of newer antibacterials, we designed and synthesized scaffolds with good antibacterial activity. The obtained antibacterials have been validated in terms of ligand-protein interaction and thus prove to build up as good drug candidates. Methods: Antibacterial activity of the compounds were carried out against bacterial strains; three Grampositive and three Gram-negative bacterial strains using agar well diffusion method. In silico molecular docking studies were carried out using Glide (grid-based ligand docking) program incorporated in the Schrödinger molecular modeling package by Maestro 11.0. Results: Compounds BC 28, BC 32, and BC 33 exhibits antibacterial activity along with Glide docking score of -8.580, -9.753 kcal/mol, and -8.813 kcal/mol, respectively. Docking studies explained hydrogen bonding, pi-pi, and hydrophobic interactions with amino acid residues which explain the binding affinity of the most docked ligand with protein. Conclusion: In the present study, substituted piperic acid was synthesized and evaluated as antibacterial compared with standard drug ciprofloxacin and results interpret that having nitrogen as heteroatom in the heterocyclic nucleus found to be more potent than the standard drug ciprofloxacin. On comparing, substitution with electron-donating groups generates excellent antibacterial potential against the bacterial strains. It was also proved that having substitution with electron-donating groups on meta and para position with triazoline ring system exhibits greater potential while compounds which have a meta- electron-donating substituent showed lesser activity with thiazole nucleus. In addition, structure-based activities of the prepared analogs were discussed under Structure-Activity Relationship (SAR) section.

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Kim, Jun-Seob, Paul Heo, Tae-Jun Yang, et al. "Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells." Antimicrobial Agents and Chemotherapy 55, no. 11 (2011): 5380–83. http://dx.doi.org/10.1128/aac.00708-11.

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ABSTRACTWe show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced cell death by causing reversion of persisters to antibiotic-sensitive cells. This work is the first demonstration in which the eradication of bacterial persisters is based on single-chemical supplementation. The chemical should be versatile in elucidating the mechanism of persistence.

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Pyanylo, Ya, and V. Sobko. "Pipeline pressure distribution finding methods." Mathematical Modeling and Computing 3, no. 2 (2016): 199–207. http://dx.doi.org/10.23939/mmc2016.02.199.

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Daneshmand, Pargol, Aurélie Randimbiarisolo, and Frank Schaper. "Tetradentate iminophenolate copper complexes in rac-lactide polymerization." Canadian Journal of Chemistry 97, no. 2 (2019): 131–39. http://dx.doi.org/10.1139/cjc-2018-0287.

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Copper(II) nitrate complexes of 2-(((2-((2-aminoethyl)amino)ethyl)imino)methyl)phenol, 2-(((2-((2-aminoethyl)amino)ethyl)imino)methyl)-4,6-dichlorophenol, 2-(((2-(piperazin-1-yl)ethyl)imino)methyl)phenol and (2,4-di-tert-butyl-6-(((2-(piperazin-1-yl)ethyl)imino)methyl)phenol, as well as a copper(II) acetate complex of 2-(((2-(piperidin-1-yl)ethyl)imino)methyl)phenol, have been prepared and characterized by X-ray diffraction studies. In combination with benzyl alcohol, all complexes are active in rac-lactide polymerization at 140 °C in molten monomer to provide moderately heterotactic polylactic acid. Most complexes showed complicated reaction kinetics, indicative of two interconverting active species. Molecular weight control was poor and a strong tendency toward intramolecular transesterification led to oligomeric products. There was no indication that the basic site of the ligand is participating in the polymerization reaction by deprotonation of the alcohol nucleophile.

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Dzhala, R. M., B. Ya Verbenets, B. I. Horon, and O. I. Senyuk. "Antiinterference determination of underground pipeline placement." Information extraction and processing 2018, no. 46 (2018): 11–18. http://dx.doi.org/10.15407/vidbir2018.46.011.

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Ternes, Waldemar, and Edburga Krause. "Characterization and determination of piperine and piperine isomers in eggs." Analytical and Bioanalytical Chemistry 374, no. 1 (2002): 155–60. http://dx.doi.org/10.1007/s00216-002-1416-6.

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Justiniano, M. R., and O. J. Romero. "INVERSION POINT OF EMULSIONS AS A MECHANISM OF HEAD LOSS REDUCTION IN ONSHORE PIPELINE HEAVY OIL FLOW." Brazilian Journal of Petroleum and Gas 15, no. 1-2 (2021): 13–24. http://dx.doi.org/10.5419/bjpg2021-0002.

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This work addresses the transportation of viscous crude oil as concentrated oil-in-water (O/W) emulsions flowing in a partially submerged onshore pipeline. The main goal of this study is to analyze the effects of inversion point of the water-in-oil emulsion in the pressure drop with the aid of Pipesim® software. Pressure drop is determined by applying the Dukler correlation (Taitel and Dukler, 1976) to represent dead oil viscosity as a function of temperature, and API density using the Hossain correlation (Hossain et al., 2005). The Brinkman model (Brinkman, 1952) is applied to calculate the viscosity of the emulsion, with the Brauner and Ullmann (2002) equation for the water cut off method (inversion point). The pipeline, of 3,600 m and 4 inches in diameter, transports the oil and consists of three sections. The first and third sections are above ground and are in contact with the external environment. The intermediate section is sitting on the river bed and is the critical part of the pipeline, once high heat losses are observed. The results of this 1D and non-isothermal problem show that water cuts of 5 and 6%, for low heat exchange and high heat exchange, respectively, make it possible to transport the oil, as an oil-in-water emulsion, through the entire extension of the pipeline. However, a water cut of 10% creates a high-pressure drop in the system, assuring the movement of the fluid in long sections without compromising the system operation. The use of isolation influences the temperature gradient but doesn’t have a high influence on pressure gradient compared to emulsions.

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Tyanev, Dimitar, and Antoniya Tyaneva. "Performance estimation of micro-pipeline based calculations." Applied Technologies and Innovations 7, no. 2 (2012): 77–81. http://dx.doi.org/10.15208/ati.2012.10.

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Romero, Oldrich Joel, Hugo Candiá Saad, Isabela Braga Pereira, and Mao Ilich Romero. "Influence of heat transfer on two-phase flow behavior in onshore oil pipelines." Ingeniería e Investigación 36, no. 1 (2016): 14–22. http://dx.doi.org/10.15446/ing.investig.v36n1.51570.

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Computational tools for simulation of multiphase flow in oil pipelines are of great importance for the determination of the technical feasibility of the production in oilfields. The present article presents the mathematical and numerical modeling of the oil biphasic flow in a partially submerged onshore pipeline. The biphasic behavior of the heavy oil of 13,2ºAPI is translated by the Dukler correlation. The oil’s viscosity is regarded as dependent on the temperature and on the API density of the oil by means of the Hossain correlation. The pipeline, of 3,600m and 4 inches (10.16cm) in diameter, transports the oil from a collecting station to a storage center and consists of three sections. The first and third sections are above ground and are in contact with the external environment. The intermediate section is sitting on the river bed and is the critical part of the pipeline, once high heat losses are observed. The influence on the type of pipe insulation in the pressure and temperature gradients was analyzed with the aid of commercial 1D software Pipesim®. The results, of this 1D and non-isothermal problem with prescribed outlet pressure, show that the use of isolation when appropriately designed in terms of material quality and thickness is of utmost importance to maintain the heat transfer at low levels, in order to ensure the movement of fluids in long sections without compromising the system operation.

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Yan, Jie, Si-Chi Xu, Chun-Yan Kong та ін. "Piperine Alleviates Doxorubicin-Induced Cardiotoxicity via Activating PPAR-γ in Mice". PPAR Research 2019 (17 грудня 2019): 1–11. http://dx.doi.org/10.1155/2019/2601408.

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Background. Oxidative stress, inflammation and cardiac apoptosis were closely involved in doxorubicin (DOX)-induced cardiac injury. Piperine has been reported to suppress inflammatory response and pyroptosis in macrophages. However, whether piperine could protect the mice against DOX-related cardiac injury remain unclear. This study aimed to investigate whether piperine inhibited DOX-related cardiac injury in mice. Methods. To induce DOX-related acute cardiac injury, mice in DOX group were intraperitoneally injected with a single dose of DOX (15 mg/kg). To investigate the protective effects of piperine, mice were orally treated for 3 weeks with piperine (50 mg/kg, 18:00 every day) beginning two weeks before DOX injection. Results. Piperine treatment significantly alleviated DOX-induced cardiac injury, and improved cardiac function. Piperine also reduced myocardial oxidative stress, inflammation and apoptosis in mice with DOX injection. Piperine also improved cell viability, and reduced oxidative damage and inflammatory factors in cardiomyocytes. We also found that piperine activated peroxisome proliferator-activated receptor-γ (PPAR-γ), and the protective effects of piperine were abolished by the treatment of the PPAR-γ antagonist in vivo and in vitro. Conclusions. Piperine could suppress DOX-related cardiac injury via activation of PPAR-γ in mice.

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Qin, Bei, Kuan Yang, and Ruijun Cao. "Synthesis and Antioxidative Activity of Piperine Derivatives Containing Phenolic Hydroxyl." Journal of Chemistry 2020 (July 21, 2020): 1–9. http://dx.doi.org/10.1155/2020/2786359.

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Piperine was used in this study in its raw form, and different steps, such as amide hydrolysis and amidation, were used to synthesize piperine derivatives containing a phenolic hydroxyl group. DPPH and ABTS free radical scavenging assays were used to assess piperine derivative antioxidant activities. We constructed an AAPH oxidative stress erythrocyte model to study the effect of piperine derivatives on the hemolysis rate of oxidatively damaged erythrocytes as well as the hemoglobin oxidation rate. This AAPH model was also used to determine piperine derivative effects on antioxidant enzyme activity and malondialdehyde (MDA) content. Results showed that spectroscopic methods could synthesize and identify piperine derivatives containing phenolic hydroxyl groups (H-1∼H-3). Moreover, DPPH and ABTS assay results showed that piperine derivative free radical clearance rates were higher compared with the parent compound. Additionally, piperine derivatives (H-1∼H-3) were found to provide protection to AAPH oxidatively damaged erythrocytes in their ability to inhibit AAPH-induced erythrocyte lysis, while hemoglobin oxidation was higher compared with the parent compound. Piperine derivatives may protect intracellular glutathione peroxidase (GSH-Px) antioxidant enzyme system activities, safeguarding against oxidative damage. This study synthesized novel piperine derivatives for use as potential antioxidant agent candidates.

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Qin, Bei, Kuan Yang, and Ruijun Cao. "Synthesis, Radical-Scavenging Activities, and Protective Effects against AAPH-Induced Oxidative Damage in DNA and Erythrocytes of Piperine Derivatives." Journal of Chemistry 2020 (March 24, 2020): 1–12. http://dx.doi.org/10.1155/2020/9026286.

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Piperine amino acid derivatives containing phenolic hydroxyl groups were synthesized using piperine as the raw material by amide hydrolysis, amidation, ester hydrolysis, and deacetalization. The obtained products were characterized by mass spectrometry and nuclear magnetic resonance. The antioxidant activity of the piperine derivatives was evaluated by the DPPH and ABTS scavenging rates and the total antioxidant capacity. The results showed that the piperine amino acid (4a–4d) had relatively weak radical-scavenging ability, while the piperine amino acid derivatives (5a–5d) containing phenolic hydroxyl groups had significant radical-scavenging effects. In addition, the total reducing ability of 5a–5d was better than that of piperine. The study also found that piperine derivatives containing phenolic hydroxyl groups played an important role in inhibiting oxidative damage in DNA and erythrocytes.

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Thiengsusuk, Artitaya, Phunuch Muhamad, Wanna Chaijaroenkul, and Kesara Na-Bangchang. "Antimalarial Activity of Piperine." Journal of Tropical Medicine 2018 (December 6, 2018): 1–7. http://dx.doi.org/10.1155/2018/9486905.

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Malaria remains a public health problem in tropical and subtropical regions. Resistance of Plasmodium falciparum to artemisinins in Southeast Asia is a great concern for disease control and research on discovery and development of new alternative antimalarial drugs is urgently required. In a previous study, the fruit of Piper chaba Hunt. was demonstrated to exhibit promising antimalarial activity against the asexual stage of 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) P. falciparum clones. The aim of the present study was to further investigate the antimalarial activity of piperine, the major isolated constituent of Piper chaba Hunt. fruits against both P. falciparum clones. The antimalarial activity was determined using SYBR green-I-based assay and morphological change was observed under the light microscope with Giemsa staining. The median IC50 (concentration that inhibits parasite growth by 50%) values of piperine against 3D7 and K1 P. falciparum were 111.5 and 59 μM, respectively. A marked change in parasite morphology was observed within 48 hours of piperine exposure. Results of real-time PCR showed no effect of piperine on modulating the expression of the three genes associated with antimalarial drug resistance in P. falciparum, i.e., pfcrt, pfmdr1, and pfmrp1. Piperine could be a promising candidate for further development as an antimalarial drug based on its antimalarial potency and low risk of resistance development.

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