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1

Hu, Qun, Wilhelm Boland, and Ji-Kai Liu. "6-Substituted Indanoyl Isoleucine Conjugate Induces Tobacco Plant Responses in Secondary Metabolites." Zeitschrift für Naturforschung C 60, no. 1-2 (2005): 1–4. http://dx.doi.org/10.1515/znc-2005-1-201.

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To characterize the role of the phytotoxin mimic 6-substituted indanoyl isoleucine conjugate 1 in plant secondary metabolism, tobacco (Nicotiana tabacum L. K326) was treated with compound 1. The volatile compounds of tobacco leaves were analyzed by GC-MS. In contrast to the control, three compounds, farnesene (2), santalol (3) and tetradecanal (4), were induced by treatment with 1 mm of compound 1. Concurrently other volatile compounds were also regulated.
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2

Grigoletto, Diana Fortkamp, Ana Maria Lima Correia, Wolf-Rainer Abraham, et al. "Secondary metabolites produced by endophytic fungi: novel antifungal activity of fumiquinone B." Acta Scientiarum. Biological Sciences 41 (December 18, 2019): e48785. http://dx.doi.org/10.4025/actascibiolsci.v41i1.48785.

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Fungi are present in the most diverse environments including the interior of plant tissues, living as endophytes without causing apparent damage. These endophytes are producers of secondary metabolites, also known as natural products, such as fungicides. Here, we evaluated the ethyl acetate fractions obtained from endophytic fungi isolated from plants in the genus Begonia. The fractions were submitted to inhibitory test against the plant pathogens Diaporthe phaseolorum and Colletotrichum gloeosporioides. From the 88 ethyl acetate fractions evaluated, 14.7 % inhibited C. gloeosporioides and 11.
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Paponov, Martina, Manya Antonyan, Rune Slimestad, and Ivan A. Paponov. "Decoupling of Plant Growth and Accumulation of Biologically Active Compounds in Leaves, Roots, and Root Exudates of Hypericum perforatum L. by the Combination of Jasmonate and Far-Red Lighting." Biomolecules 11, no. 9 (2021): 1283. http://dx.doi.org/10.3390/biom11091283.

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The plant hormone jasmonic acid (JA) fine tunes the growth–defense dilemma by inhibiting plant growth and stimulating the accumulation of secondary compounds. We investigated the interactions between JA and phytochrome B signaling on growth and the accumulation of selected secondary metabolites in Hypericum perforatum L., a medically important plant, by spraying plants with methyl jasmonate (MeJA) and by adding far-red (FR) lighting. MeJA inhibited plant growth, decreased fructose concentration, and enhanced the accumulation of most secondary metabolites. FR enhanced plant growth and starch ac
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4

Le, Tu Cam, Kyung-Yun Kang, Inho Yang, et al. "A New Secondary Metabolite from Korean Traditional Herb Plant Hovenia dulcis." Natural Product Communications 13, no. 4 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300418.

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Investigation of chemical compounds from the butanol soluble layer of the traditional herb Hovenia dulcis has led to the isolation of a new compound, identified as 2-methoxybenzoic acid-5- O-α-L-rhamnopyranoside (1), along with three known compounds, syringic acid-4- O-α-L-rhamnopyranoside (2), syringic acid (3), and vanillic acid (4). Their chemical structures were established from the interpretation of 2D NMR spectroscopic and the high-resolution mass data.
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5

Céspedes, Carlos L., Julio E. Alarcon, Pedro Aqueveque, David S. Seigler, and Isao Kubo. "In the search for new secondary metabolites with biopesticidal properties." Israel Journal of Plant Sciences 62, no. 4 (2015): 216–28. http://dx.doi.org/10.1080/07929978.2015.1006424.

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Secondary metabolites are involved in diverse functions in plants, including defense and protective processes. Information concerning the biosynthesis of secondary metabolites in plants points at a constitutive or induced chemical defense, generated for protection against a variety of phytopathogenic attacks. Our phytochemical studies are aimed at finding biopesticides of botanical origin. Some plant taxa of American distribution are toxic to selected insects, fungi and bacterial strains, and their effect has been associated with the presence of phenolics, phenylpropanoids and terpenes. We hav
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Roy, Arpita. "Hairy Root Culture an Alternative for Bioactive Compound Production from Medicinal Plants." Current Pharmaceutical Biotechnology 22, no. 1 (2020): 136–49. http://dx.doi.org/10.2174/1389201021666201229110625.

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: Medicinal plants produce a diverse group of phytocompounds like anthraquinones, alkaloids, anthocyanins, flavonoids, saponins, and terpenes which are used in pharmaceutical, perfume, cosmetics, dye and flavor industries. Commercial source of these metabolites is field-grown plants, which are generally influenced by seasonal changes. Biotechnology possesses a significant role in production of high-value secondary metabolites. By incorporating biotechnological methods, it is feasible to manage biosynthetic pathways of the plant to enhance phytocompound production that is of pharmaceutical inte
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Agrawal, Shashi Bhushan, and Deepanshi Jaiswal. "Impact of Light Stress on Plant Based Medicinally Active Compounds." INTERNATIONAL JOURNAL OF PLANT AND ENVIRONMENT 4, no. 02 (2018): 50–59. http://dx.doi.org/10.18811/ijpen.v4i02.6.

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Light has several positive and negative impacts on plant growth and physiological processes. Medicinal plants contribute significantly higher proportions of world plant flora and are natural source of rich medicinal compounds. Sufficient literature is available on plant responses to light stress but studies on medicinal plants are limited. This review discusses how different light conditions affect production of plant-based medicinal compounds which are broadly secondary products formed during adverse environmental conditions to cope up the stress. Here, some medicinal plants are reviewed whic
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8

Sun, Sen-Feng, Shao Zhu, Hai-Yan Cao, Yun-Bao Liu, and Shi-Shan Yu. "Tridepsides from the endophytic fungus colletotrichum gloeosporioides associated with a toxic medicinal plant tylophora ovata." Frigid Zone Medicine 1, no. 1 (2021): 45–51. http://dx.doi.org/10.2478/fzm-2021-0006.

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Abstract Introduction Bioactive secondary metabolites from the microbes living in frigid, toxic or other extreme environments are emerging as a new medicinal resource. Here, we report the discovery of new antidiabetic and anti-inflammatory compounds with novel structures from endophytic fungi hosted toxic medicinal plant. Methods The endophytic fungus isolated from toxic plants was fermented and extracted. The obtained extracts were purified with preparative HPLC to yield pure compounds. The purified compounds were examined by PTP1b inhibition and NO inhibition assays to evaluate their bioacti
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9

Soesanto, Loekas, Endang Mugiastuti, and Abdul Manan. "Raw Secondary Metabolites Application of Two Trichoderma harzianum Isolates towards Vascular Streak Dieback on Cocoa Seedlings." Pelita Perkebunan (a Coffee and Cocoa Research Journal) 35, no. 1 (2019): 22–32. http://dx.doi.org/10.22302/iccri.jur.pelitaperkebunan.v35i1.346.

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 Vascular streak dieback is an important disease on cocoa that recently is still difficult to control. This research aimed to study the raw secondary metabo- lites application effectiveness of Trichoderma harzianum T10 and T213, or their combination to vascular streak dieback and its effect on growth and on phenolic compound of cocoa seedlings. Randomized block design was used with nine replicates. The treatments were control, secondary metabolites of T. harzianumT10 and T213, their combination and fungicide with active ingredient of phosphic acid. Variables observed were i
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10

Guo, Longfang, Jie Lin, Shubin Niu, Shuchun Liu, and Ling Liu. "Pestalotiones A–D: Four New Secondary Metabolites from the Plant Endophytic Fungus Pestalotiopsis Theae." Molecules 25, no. 3 (2020): 470. http://dx.doi.org/10.3390/molecules25030470.

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Two new xanthone derivatives, pestalotiones A (1) and B (2), one new diphenyl ketone riboside, pestalotione C (7), and one new diphenyl ether, pestalotione D (8), along with five known compounds isosulochrin dehydrate (3), 3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (4), isosulochrin (5), chloroisosulochrin (6), and pestalotether D (9), were isolated from the crude extract of the plant endophytic fungus Pestalotiopsis theae (N635). The structures of the new compounds were unambiguously deduced by HRESIMS and 1D/2D-NMR spectroscopic data. Compound 6 showed modest cytotoxicity against
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11

Layne, Tanya H., William F. Reynolds, Stewart McLean, and Winston F. Tinto. "Secondary Metabolites from Clerodendrum Chinense." Natural Product Communications 3, no. 11 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301108.

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Chemical studies carried out on Clerodendrum chinense yielded three new compounds including the steroid (22E, 24S)-stigmasta-4, 22, 25-trien-3-one (1), the flavone glycoside 7, 8, 4′-trihydroxyflavone-6-O-β-D-glucuronopyranoside (2) and the epimeric neo-clerodane 14, 15-dihydro-15ξ-hydroxyclerodendrin A (3). Two acetylated derivatives of compound 3-, 2α-acetoxy-14, 15-dihydro-15ξ-hydroxyclerodendrin A (4) and 2α-acetoxy-14, 15-dihydro-15ξ-methoxyclerodendrin A (5) were also prepared, which have not been reported previously. The structure of each compound was elucidated by spectroscopic means.
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12

Thi, Quyen Vu, Van Hieu Tran, Huong Doan Thi Mai, et al. "Secondary Metabolites from an Actinomycete from Vietnam's East Sea." Natural Product Communications 11, no. 3 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100320.

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Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete Nocardiopsis sp. (strain G057) led to the isolation of twelve compounds, 1–12. Compound 1 (2-[(2 R-hydroxypropanoyl)amino]benzamide) was found to be a new enantiomeric isomer while compounds 2 (3-acetyl-4-hydroxycinnoline) and 3 (3,3′-bis-indole) were isolated from a natural source for the first time. The structures of 1 – 12 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. C
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13

Veatch-Blohm, Maren E., and Dennis T. Ray. "(453) Effect of Drought Stress on Growth and Secondary Compound Production in Greenhouse-grown Guayule." HortScience 40, no. 4 (2005): 1036B—1036. http://dx.doi.org/10.21273/hortsci.40.4.1036b.

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As a native of the Chihuahuan desert, guayule (Partheniumargentatum Gray) has a history of dealing with low water availability. Agronomic studies have shown that increasing irrigation increases overall rubber yields, but decreases rubber concentration per plant. As water availability is an important factor in agricultural production, this study was conducted to examine how drought affects plant growth and secondary compound distribution throughout the plant. One-year-old guayule plants were subjected to water stress from June through August, in 2003 and 2004. The well-watered treatment was irr
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14

Madiyawati, Milad, Penyang Penyang, Fouad Fauzi, and Antonius Triyadi. "Karakteristik Dan Uji Fitokimia 5 (Lima) Jenis Tumbuhan Buah Eksotik dari Kabupaten Barito Utara Kalimantan Tengah." Daun: Jurnal Ilmiah Pertanian dan Kehutanan 4, no. 1 (2018): 47–54. http://dx.doi.org/10.33084/daun.v4i1.105.

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This study was conducted to identify the characteristics of fruit plants (generally, the environment/habitat and plant morphology fruit) and to determine the content of active compounds (secondary metabolites) plant worth exotic fruit contained in North Barito. This study used survey methods and data analysis was done descriptively qualitative and quantitative in tabular form and image. The results of the study characteristics and phytochemical test five (5) pieces of exotic plant species in North Barito regency from habitat plant fruit trees and lianas, with the composition of single and comp
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15

Shrivastava, Rashmi, and Jyotsana Mishra. "Extraction, Phytochemical Screening, Isolation and Identification of Bioactive Compounds from Extract of the plant Euphorbia Thymifolia Linn." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 107–13. http://dx.doi.org/10.22270/jddt.v9i3.2608.

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Medicinal plants play an important role in the development of potent therapeutic agents. Plant based drugs provide outstanding contribution to modern therapeutics as a source of many valuable secondary metabolites which serves as plant defense mechanisms against predator such as microorganism, insects and herbivores which have been proved to be potentially active compounds. Euphorbia Thymifolia Linn (E. Thymifolia) is commonly known as ‘duddi’ or in Sanskrit means Laghu didhika or Raktavindaka. It belongs to the family Euphorbiceae. This plant is bitter, acrid, sweet and used as thermogenic, l
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16

Herlina, Tati, and Unang Supratman. "Kuersetin dari Daun Erythrina poeppigiana (leguminosae)." Jurnal Natur Indonesia 17, no. 1 (2017): 1. http://dx.doi.org/10.31258/jnat.17.1.1-4.

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Erythrina plants known plants “dadap” is a higher plant that grows in tropical and subtropical regions. E. poeppigiana plants was a source of secondary metabolites, which contain flavonoids. This study aims to isolate the flavonoid compounds from the leaves of E. poeppigiana through the stages of extraction, fraction, separation and purification. E. poeppigiana leaves powder (2.5 kg) was extracted with methanol and partitioned with n-hexane and ethyl acetate. Furthermore, the separation of ethyl acetate of E. poeppigiana leaves fraction using a combination of column chromatographic was obtaine
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17

Grilli, Eleonora, Esterina Di Resta, Scognamiglio Monica, et al. "Soil phenolic compound variability in two Mediterranean olive groves." Plant, Soil and Environment 66, No. 5 (2020): 207–15. http://dx.doi.org/10.17221/165/2020-pse.

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Phenolic compounds (PCs) – with special reference to secondary plant metabolites – were characterised in two Mediterranean olive groves (Olea europaea L.). Representative pedological profiles were dug to identify and characterise the pedotype. Qualitative and quantitative analyses were carried out on soil core samples gathered at fixed depths (0–20 cm and 20–40 cm) and olive leaf methanol extracts by high-performance liquid chromatography with ultraviolet detection. The total PCs content reflected the soil organic carbon distribution, especially carbon of humic and fulvic acids, corroborating
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18

Valdés-Jiménez, Alejandro, Carlos Peña-Varas, Paola Borrego-Muñoz, et al. "PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds." Molecules 26, no. 4 (2021): 1124. http://dx.doi.org/10.3390/molecules26041124.

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Plants synthesize a large number of natural products, many of which are bioactive and have practical values as well as commercial potential. To explore this vast structural diversity, we present PSC-db, a unique plant metabolite database aimed to categorize the diverse phytochemical space by providing 3D-structural information along with physicochemical and pharmaceutical properties of the most relevant natural products. PSC-db may be utilized, for example, in qualitative estimation of biological activities (Quantitative Structure-Activity Relationship, QSAR) or massive docking campaigns to id
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19

Mahato, Tapan K., and K. Sharma. "STUDY OF MEDICINAL HERBS AND ITS ANTIBACTERIAL ACTIVITY: A REVIEW." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 47–54. http://dx.doi.org/10.22270/jddt.v8i5-s.1938.

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The beneficial medicinal effects of plant materials typically result from the secondary products present in the plant although, it is usually not attributed to a single compound but a combination of the metabolites. The medicinal actions of plants are unique to a particular plant species or group, consistent with the concept that the combination of secondary products in a particular plant is taxonomically distinct.The screening of plants usually involves several approach; ethno botanical approach is one of the common methods that are employed in choosing the plant for pharmacological study. In
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20

Ghoneim, Mohammed M., Guoyi Ma, Atef A. El-Hela, et al. "Biologically Active Secondary Metabolites from Asphodelus Microcarpus." Natural Product Communications 8, no. 8 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800822.

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Bioassay guided fractionation of the ethanolic extract of Asphodelus microcarpus Salzm.et Vivi (Asphodelaceae) resulted in the isolation of one new metabolite, 1,6-dimethoxy-3-methyl-2-naphthoic acid (1) as well as nine known compounds: asphodelin (2), chrysophanol (3), 8-methoxychrysophanol (4), emodin (5), 2-acetyl-1,8-dimethoxy-3-methylnaphthalene (6), 10-(chrysophanol-7’-yl)-10-hydroxychrysophanol-9-anthrone (7), aloesaponol-III-8-methyl ether (8), ramosin (9) and aestivin (10). The compounds were identified by 1D and 2D NMR and HRESIMS. Compounds 3, 6 and 10 were isolated for the first ti
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Motoyama, Takayuki. "Secondary Metabolites of the Rice Blast Fungus Pyricularia oryzae: Biosynthesis and Biological Function." International Journal of Molecular Sciences 21, no. 22 (2020): 8698. http://dx.doi.org/10.3390/ijms21228698.

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Plant pathogenic fungi produce a wide variety of secondary metabolites with unique and complex structures. However, most fungal secondary metabolism genes are poorly expressed under laboratory conditions. Moreover, the relationship between pathogenicity and secondary metabolites remains unclear. To activate silent gene clusters in fungi, successful approaches such as epigenetic control, promoter exchange, and heterologous expression have been reported. Pyricularia oryzae, a well-characterized plant pathogenic fungus, is the causal pathogen of rice blast disease. P. oryzae is also rich in secon
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Radušienė, Jolita, Birutė Karpavičienė, and Žydrūnas Stanius. "Effect of External and Internal Factors on Secondary Metabolites Accumulation in St. John’s Worth." Botanica Lithuanica 18, no. 2 (2012): 101–8. http://dx.doi.org/10.2478/v10279-012-0012-8.

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Abstract Radušienė J., Karpavičienė B., Stanius Ž., 2012: Effect of external and internal factors on secondary metabolites accumulation in St. John’s worth [Vidinių ir išorinių faktorių įtaka antrinių metabolitų kaupimuisi paprastojoje jonažolėje]. - Bot. Lith., 18(2): 101-108. The effect of modified external factors such as temperature and light intensity, and plant internal factors - phenological phase and their possible interaction was investigated on accumulation of bioactive secondary metabolites in Hypericum perforatum L. The plants were grown under different temperature and light intens
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23

Machado, Silvia Rodrigues, Carmen Regina Marcati, Berta Lange de Morretes, and Veronica Angyalossy. "Comparative Bark Anatomy of Root and Stem in Styrax Camporum (Styracaceae)." IAWA Journal 26, no. 4 (2005): 477–87. http://dx.doi.org/10.1163/22941932-90000129.

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The bark of Styrax camporum Pohl (Styracaceae) differs anatomically in the root and stem. Roots have layered secondary phloem; short sieve tubes with simple, transverse or more or less inclined sieve plates; fibres in tangential bands; astrosclereids; wide rays, and a poorly developed periderm. Stems have non-layered secondary phloem; longer sieve tubes with compound, scalariform, inclined sieve plates; sclerified cells and brachysclereids; a developed periderm, and a non-persistent rhytidome. Prismatic crystals, starch grains, phenolic compounds and lipidic contents were observed in root and
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24

K, Kannan, Rajesh Kannan V, Shibinaya N, and Umamaheswari M. "Control Of Fusarium Wilt Disease In Cowpea Plant (Vigna Unguiculata L.). Using Secondary Metabolites Produced In Bradyrhizobium Japonicum." Kongunadu Research Journal 6, no. 2 (2019): 28–36. http://dx.doi.org/10.26524/krj298.

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Rhizobium known for its nitrogen fixation and plant growth promoting capabilities which is symbiotically associative with legume plants. So forth Rhizobium used as biofertilizers in the agriculture. The ability of controlling plant diseases by using Rhizobium produced secondary metabolites as biocontrol agent is the current open area in the agriculture research. The nodules inhabited Rhizobium strains were selected for the production of secondary metabolites and the ability of controlling Fusarium was evaluated preliminarily by agar well diffusion assay. Four different Rhizobium were isolated,
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Bukvicki, Danka, Miroslav Novakovic, Tatjana Ilic-Tomic, et al. "Biotransformation of Perrottetin F by Aspergillus niger: New Bioactive Secondary Metabolites." Records of Natural Products 15, no. 4 (2021): 281–92. http://dx.doi.org/10.25135/rnp.215.20.09.1812.

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Biotransformation of bis-bibenzyl perrottetin F (1), isolated from the liverwort Lunularia cruciata by Aspergillus niger, has been investigated. New metabolites (2-4) have been isolated using reversed phase semipreparative HPLC and their structures were established to be 8-hydroxyperrottetin F, C-7-C-8 cleaved product, and perrottetin F 6’-sulfate using 1D and 2D NMR, HR-ESI-MS, IR and UV spectroscopy. The antimicrobial and cytotoxic properties of these compounds were also evaluated. Given the suggested cytotoxic properties of the parent compound, antiproliferative activity against healthy hum
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Guo, Zhiyong, Fan Cheng, Kun Zou, Junzhi Wang, Zhigang She, and Yongcheng Lin. "Secondary Metabolites from the Mangrove Endophytic Fungus Penicillium sp. (SBE-8)." Natural Product Communications 4, no. 11 (2009): 1934578X0900401. http://dx.doi.org/10.1177/1934578x0900401108.

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A new metabolite, 7-hydroxyjanthinone (1), was isolated from the mangrove endophytic fungus Penicillium sp. (SBE-8), together with two known compounds, janthinone (2) and citrinin (3). The structures of these compounds were identified by spectroscopic methods. Compounds 1 and 2 showed no cytotoxicity against KB and KBv cell lines when tested by the MTT method, but compound 3 was weakly active.
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Alibi, Sana, Dámaso Crespo, and Jesús Navas. "Plant-Derivatives Small Molecules with Antibacterial Activity." Antibiotics 10, no. 3 (2021): 231. http://dx.doi.org/10.3390/antibiotics10030231.

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The vegetal world constitutes the main factory of chemical products, in particular secondary metabolites like phenols, phenolic acids, terpenoids, and alkaloids. Many of these compounds are small molecules with antibacterial activity, although very few are actually in the market as antibiotics for clinical practice or as food preservers. The path from the detection of antibacterial activity in a plant extract to the practical application of the active(s) compound(s) is long, and goes through their identification, purification, in vitro and in vivo analysis of their biological and pharmacologic
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Ortega, Humberto, Daniel Torres-Mendoza, Zuleima Caballero E., and Luis Cubilla-Rios. "Structurally Uncommon Secondary Metabolites Derived from Endophytic Fungi." Journal of Fungi 7, no. 7 (2021): 570. http://dx.doi.org/10.3390/jof7070570.

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Among microorganisms, endophytic fungi are the least studied, but they have attracted attention due to their high biological diversity and ability to produce novel and bioactive secondary metabolites to protect their host plant against biotic and abiotic stress. These compounds belong to different structural classes, such as alkaloids, peptides, terpenoids, polyketides, and steroids, which could present significant biological activities that are useful for pharmacological or medical applications. Recent reviews on endophytic fungi have mainly focused on the production of novel bioactive compou
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Faiola, C. L., M. Wen, and T. M. VanReken. "Chemical characterization of biogenic secondary organic aerosol generated from plant emissions under baseline and stressed conditions: inter- and intra-species variability for six coniferous species." Atmospheric Chemistry and Physics 15, no. 7 (2015): 3629–46. http://dx.doi.org/10.5194/acp-15-3629-2015.

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Abstract. The largest global source of secondary organic aerosol (SOA) in the atmosphere is derived from the oxidation of biogenic emissions. Plant stressors associated with a changing environment can alter both the quantity and composition of the compounds that are emitted. Alterations to the biogenic volatile organic compound (BVOC) profile could impact the characteristics of the SOA formed from those emissions. This study investigated the impacts of one global change stressor, increased herbivory, on the composition of SOA derived from real plant emissions. Herbivory was simulated via appli
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Lee, Chia-Lin, Tsong-Long Hwang, Chieh-Yu Peng, Chao-Jung Chen, Yuan-Shiun Chang, and Yang-Chang Wu. "Anti-neutrophilic Inflammatory Secondary Metabolites from the Traditional Chinese Medicine, Tiankuizi." Natural Product Communications 7, no. 12 (2012): 1934578X1200701. http://dx.doi.org/10.1177/1934578x1200701221.

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Through bioassay-guided fractionation, thirteen compounds (1-13) were isolated from the dry root of Semiaquilegia adoxoides, known as Tiankuizi in traditional Chinese medicine (TCM). Among these, four benzoic acid derivatives (1, 2, 4, 5), one 4,6-dimethoxy-5-methyl-2 H-pyran-2-one (10) and one 1,2,3-propanetriol (13) were found for the first time in S. adoxoides. This is the first record of compound 10 from a natural source. 4-Hydroxybenzoic acid (1) and 3,4-dihyroxybenzoic acid (2) showed selective inhibition against elastase release and superoxide anion generation, with IC50 values of 3.20
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Corrêa, Joze Aparecida Marciano, Diana Fortkamp, Camila Furtunato da Silva, et al. "Biological activity of 7beta-acetoxywithanolide D isolated from Acnistus arborescens." Semina: Ciências Agrárias 39, no. 6 (2018): 2835. http://dx.doi.org/10.5433/1679-0359.2018v39n6p2835.

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Many oomycete species are plant pathogens and are responsible for causing significant losses in agriculture. Currently, plant pathogen control is carried out by chemical, biological and physical methods. However, due to the development of resistance to these methods by some pathogens, it is imperative that alternative methods are developed. Brazilian biodiversity is well-known for its species richness and is considered a promising source of natural products. Among the vascular plants, the family Solanaceae A. Juss. (Solanaceae) is considered one of the largest, with distributions across all tr
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Holzmeyer, Laura, Anne-Kathrin Hartig, Katrin Franke, et al. "Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic, spatial, and bioactivity data." Proceedings of the National Academy of Sciences 117, no. 22 (2020): 12444–51. http://dx.doi.org/10.1073/pnas.1915277117.

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Antibiotic resistance and viral diseases are rising around the world and are becoming major threats to global health, food security, and development. One measure that has been suggested to mitigate this crisis is the development of new antibiotics. Here, we provide a comprehensive evaluation of the phylogenetic and biogeographic patterns of antiinfective compounds from seed plants in one of the most species-rich regions on Earth and identify clades with naturally occurring substances potentially suitable for the development of new pharmaceutical compounds. Specifically, we combine taxonomic an
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Knez Hrnčič, Maša, Darija Cör, Jana Simonovska, Željko Knez, Zoran Kavrakovski, and Vesna Rafajlovska. "Extraction Techniques and Analytical Methods for Characterization of Active Compounds in Origanum Species." Molecules 25, no. 20 (2020): 4735. http://dx.doi.org/10.3390/molecules25204735.

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Phytochemical research based on ethnopharmacology is gaining interest in industries such as functional food, nutraceuticals, cosmetics and pharmaceutical industries. Plants and plant extracts are a rich source of bioactive secondary metabolites. These compounds are often involved in plant protection against biotic or abiotic stresses. The exploitation of available technologies should be oriented and intensified to extend and enhance the continued usefulness of the plants as renewable sources of chemicals, especially medicinal compounds. This current contribution is focused on extraction and an
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Ren, Shien, Chao Fan, Liangzhi Zhang, et al. "The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)." Applied Microbiology and Biotechnology 105, no. 16-17 (2021): 6419–33. http://dx.doi.org/10.1007/s00253-021-11478-6.

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Abstract Plants produce various plant secondary compounds (PSCs) to deter the foraging of herbivorous mammals. However, little is known about whether PSCs can reshape gut microbiota and promote gut homeostasis of hosts. Using 16S rDNA sequencing to investigate the effects of PSCs on the gut microbiota of small herbivorous mammals, we studied plateau pikas (Ochotona curzoniae) fed diets containing swainsonine (SW) extracted from Oxytropis ochrocephala. Our results showed that both long- and short-term treatment of a single artificial diet in the laboratory significantly reduced alpha diversity
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Prakash, Ved. "TERPENOIDS AS SOURCE OF ANTI-INFLAMMATORY COMPOUNDS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 68. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16435.

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ABSTRACTTerpenoids accounts for the major class of secondary metabolites produced by plants. It shows defense activity against environmental stress and helpto heal injuries. Medicinal plants are rich in monoterpenoids, diterpenoids, sesquiterpenes, triterpenes, tetraterpenes, and ceramide. A number oftherapeutic applications such as antibacterial, antimicrobial, antitumor, anti-inflammatory activity have been identified. Terpenoids are compoundssimilar to terpenes derived from 5-carbon monomer isoprene units. The review puts and detail insight on different class of compounds isolated fromnatur
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Zhao, Haiguang, Xiangen Xu, Fan Ke, Wenchao Li, Muhua Feng, and Houhu Zhang. "Nitrogen removal from wastewater plant secondary effluent in a compound natural treatment system." Ecological Engineering 57 (August 2013): 361–65. http://dx.doi.org/10.1016/j.ecoleng.2013.04.026.

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Stolter, C., John P. Ball, and R. Julkunen-Tiitto. "Seasonal differences in the relative importance of specific phenolics and twig morphology result in contrasting patterns of foraging by a generalist herbivore." Canadian Journal of Zoology 91, no. 5 (2013): 338–47. http://dx.doi.org/10.1139/cjz-2012-0270.

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The co-evolved relationship between the chemical composition of plants and herbivory is fundamental in understanding diet selection of herbivores and their impacts on plants and ecosystems. However, the impact of plant secondary chemistry on mammalian herbivory is not fully understood. We investigated seasonal influences of phenolics with low molecular weight (e.g., flavonoids, salicylates) and plant morphology of the tea-leaved willow (Salix phylicifolia L.) on moose (Alces alces (L., 1758)) foraging. We analysed the relationship of different phenolic compounds in twigs and browsing in winter
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Dusan, Vukmirovic, Rollo Dave, Seymour Colin, and Mothersill Carmel. "Cytotoxic Profiling of Plant Secondary Metabolites on P53 Variant Human Colon Carcinoma Cell Lines." Dose-Response 15, no. 4 (2017): 155932581774812. http://dx.doi.org/10.1177/1559325817748121.

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Chemoprevention strategies employ the use of compounds to inhibit the initiation, promotion, and progression phases of carcinogenesis. The successful chemopreventative candidate must therefore (1) selectively inhibit growth of transformed cells and (2) be administered on a frequent basis to confer maximal protection. Phytochemicals are a subclass of bioactive plant secondary metabolites that exhibit antioxidative, anticarcinogenic, and anti-inflammatory properties contributing to proper cell function. To assess the effectiveness of these compounds warrants an understanding of their cytotoxic m
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Taghinasab, Meysam, and Suha Jabaji. "Cannabis Microbiome and the Role of Endophytes in Modulating the Production of Secondary Metabolites: An Overview." Microorganisms 8, no. 3 (2020): 355. http://dx.doi.org/10.3390/microorganisms8030355.

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Plants, including cannabis (Cannabis sativa subsp. sativa), host distinct beneficial microbial communities on and inside their tissues and organs, including seeds. They contribute to plant growth, facilitating mineral nutrient uptake, inducing defence resistance against pathogens, and modulating the production of plant secondary metabolites. Understanding the microbial partnerships with cannabis has the potential to affect the agricultural practices by improving plant fitness and the yield of cannabinoids. Little is known about this beneficial cannabis-microbe partnership, and the complex rela
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Rahayu, Tintrim, Radita Intan Aisyah Pratiwi, and Nurul Jadid Mubarakati. "Profil Metabolit Daun Kesambi (Schleichera oleosa) Berdasarkan Analisis Histokimia dan In Silico." Metamorfosa: Journal of Biological Sciences 8, no. 1 (2021): 156. http://dx.doi.org/10.24843/metamorfosa.2021.v08.i01.p17.

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Kesambi (Schleichera oleosa) is a plant belonging to the Sapindaceae familia. This study aims to determine the secondary metabolite compounds found in kesambi leaves through histochemical analysis and derivatives of active compounds in silico. Descriptive experimental research method was conducted in January using samples of kesambi plants that grow on the island of Madura. Histochemical analysis was carried out by preparing fresh leaves through lower leaf incisions with secondary metabolite detection reagents (CuSO4, FeCl3, Wagner, Sudan III, AlCl3 & FeCl3+NaCO3) then microscopic color ch
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Hien, Truong Thi Thu, Tran Hong Quang, Nguyen Xuan Nhiem, et al. "Bioactive Secondary Metabolites from the Aerial Parts of Buddleja macrostachya." Natural Product Communications 12, no. 12 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201201.

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A new iridoid glycoside, buddlemacroside A (1) and 15 known compounds, including 6-α-L-(4″- O-trans-p-coumaroyl)rhamnopyranosylcatalpol (2), 6-α-L-(2″-caffeoyl)rhamnopyranosylcatalpol (3), salidroside (4), echipuroside A (5), darendoside A (6), decaffeoylacteoside (7), acteoside (8), martynoside (9), 8-hydroxylinalool 3- O-β-D-glucopyranoside (10), 9- O-α-L-rhamnopyranosyl-4-hydroxy-cinnamic acid (11), apigenin (12), acacetin-7- O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (13), mimengoside C (14), buddlejasaponin Ia (15), and buddejasaponin I (16) were isolated from a methanol extract of t
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Landis, D. A., and F. Gould. "SCREENING FOR PHYTO-PROTECTANTS TO GUARD CORN SEEDS/SEEDLINGS FROM SOUTHERN CORN ROOTWORM FEEDING INJURY." Journal of Entomological Science 23, no. 3 (1988): 201–11. http://dx.doi.org/10.18474/0749-8004-23.3.201.

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A screening program was developed to detect chemicals without acute toxicity that could protect seedling corn from injuiy by southern corn rootworm (SCR), Diabrotica undecimpunctata howardi Barber. Crude plant extracts, purified secondary plant compounds and agricultural fungicides were screened in a no-choice laboratory bioassay using germinating corn seeds in soil. Promising candidates were further tested in a greenhouse assay. Chemicals were evaluated on the ability to reduce the number of plants damaged and the severity of SCR feeding. A seed treatment fungicide, thiram, energed as the mos
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Qader, Mallique, KH Ahammad Uz Zaman, Zhenquan Hu, Cong Wang, Xiaohua Wu, and Shugeng Cao. "Aspochalasin H1: A New Cyclic Aspochalasin from Hawaiian Plant-Associated Endophytic Fungus Aspergillus sp. FT1307." Molecules 26, no. 14 (2021): 4239. http://dx.doi.org/10.3390/molecules26144239.

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Aspergillus is one of the most diverse genera, and it is chemically profound and known to produce many biologically active secondary metabolites. In the present study, a new aspochalasin H1 (1), together with nine known compounds (2–10), were isolated from a Hawaiian plant-associated endophytic fungus Aspergillus sp. FT1307. The structures were elucidated using nuclear magnetic resonance (NMR) (1H, 1H-1H COSY, HSQC, HMBC, ROESY and 1D NOE), high-resolution electrospray ionization mass spectroscopy (HRESIMS), and comparisons with the reported literature. The absolute configuration of the new co
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Kamada, Takashi, and Charles Santhanaraju Vairappan. "New Bioactive Secondary Metabolites from Bornean Red Alga, Laurencia similis (Ceramiales)." Natural Product Communications 8, no. 3 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800302.

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A Bornean red algal population of Laurencia simlis Nam et Saito was analyzed for its secondary metabolite composition. Seven compounds were identified: ent -1(10)-aristolen-9β-ol (1), (+)-aristolone (2), axinysone B (3), 9-aristolen-1α-ol (4), 2,3,5,6-tetrabromoindole (5), 1-methyl-2,3,5,6-tetrabromoindole (6), and 1-methyl-2,3,5-tribromoindole (7). Compound 1 was identified as a new optical isomer of 1(10)-aristolen-9β-ol. Compounds 1, 4 and 5 exhibited good antibacterial activity against antibiotic resistant clinical bacteria and cytotoxic effects against selected cancer cell lines.
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McEvoy, Maria, Line Nybakken, Knut Asbjørn Solhaug, and Yngvar Gauslaa. "UV triggers the synthesis of the widely distributed secondary lichen compound usnic acid." Mycological Progress 5, no. 4 (2006): 221–29. http://dx.doi.org/10.1007/s11557-006-0514-9.

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Iason, Glenn R., Julianne M. O'Reilly-Wapstra, Mark J. Brewer, Ron W. Summers, and Ben D. Moore. "Do multiple herbivores maintain chemical diversity of Scots pine monoterpenes?" Philosophical Transactions of the Royal Society B: Biological Sciences 366, no. 1569 (2011): 1337–45. http://dx.doi.org/10.1098/rstb.2010.0236.

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A central issue in our understanding of the evolution of the diversity of plant secondary metabolites (PSMs) is whether or not compounds are functional, conferring an advantage to the plant, or non-functional. We examine the hypothesis that the diversity of monoterpene PSMs within a plant species (Scots pine Pinus sylvestris ) may be explained by different compounds acting as defences against high-impact herbivores operating at different life stages. We also hypothesize that pairwise coevolution, with uncorrelated interactions, is more likely to result in greater PSM diversity, than diffuse co
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Pacheco, Ana Cláudia, Leonardo Araujo Sobral, Pedro Henrique Gorni, and Marcia Eugenia Amaral Carvalho. "Ascophyllum nodosum extract improves phenolic compound content and antioxidant activity of medicinal and functional food plant Achillea millefolium L." 2019 13, (03) 2019 (2019): 418–23. http://dx.doi.org/10.21475/ajcs.19.13.03.p1342.

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Genetic, biochemical and physiological parameters can be changed by applying seaweed extract-based products. However, there is scarce information about the influence of seaweed extract on yarrow performance (Achillea millefolium L.), which is widely used in the folk medicine. Therefore, this study aimed to evaluate the effects of Ascophyllum nodosum extract on plant development (leaf and root biomass, and leaf area), physiological indexes (leaf weight ratio, and root: leaf ratio), secondary metabolite (phenolic compounds) content and antioxidant activity of yarrow. The experiment was carried o
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Duncan, Alan J., Pilar y, and Sheila A. Young. "The effect of rumen adaptation to oxalic acid on selection of oxalic–acid–rich plants by goats." British Journal of Nutrition 83, no. 1 (2000): 59–65. http://dx.doi.org/10.1017/s000711450000009x.

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Rumen microbial degradation is an important route for detoxification of secondary plant compounds encountered in the diets of free-grazing ruminants. Exposure to diets containing particular secondary plant compounds can lead to increased rates of secondary compound degradation in the rumen. An experiment was conducted to determine whether rumen adaptation to oxalic acid would influence the diet selection of goats offered choices between plant species differing in their oxalic acid content. Twelve adult female goats were divided into two groups of six animals each. One group received a daily or
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Rodríguez Marañón, M. J., D. Mercier, R. B. van Huystee, and M. J. Stillman. "Analysis of the optical absorption and magnetic-circular-dichroism spectra of peanut peroxidase: electronic structure of a peroxidase with biochemical properties similar to those of horseradish peroxidase." Biochemical Journal 301, no. 2 (1994): 335–41. http://dx.doi.org/10.1042/bj3010335.

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The electronic structures of the cationic isoenzyme of peanut peroxidase, horseradish peroxidase (isoenzyme C) and bovine liver catalase are compared through analysis of their optical absorption and magnetic c.d. (m.c.d.) spectral properties. The spectral data for the native resting states and compounds I and II of peanut peroxidase (PeP) are reported. The absorption and m.c.d. data for the native PeP exhibit bands characteristic of the high-spin ferric haem. The absorption spectrum of PeP compound I closely resembles that observed for the HRP compound I species. The m.c.d. data for PeP I clea
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Goldner, W. R., F. M. Hoffman, and R. J. Medve. "Allelopathic effects of Cladonia cristatella on ectomycorrhizal fungi common to bituminous strip-mine spoils." Canadian Journal of Botany 64, no. 8 (1986): 1586–90. http://dx.doi.org/10.1139/b86-212.

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Acetone–toluene extracts of Cladonia cristatella inhibited the growth of fungi known to form ectomycorrhizal associations with trees commonly found on bituminous strip-mine spoils in western Pennsylvania. Growth of Pisolithus tinctorius and Suillus luteus was completely inhibited by C. cristatella extracts over a 30-d bioassay period. Thelephora terrestris was dead after 17 d. The growth of Cenococcum graniforme was unaffected by lichen extracts. D-Usnic acid, a major secondary compound of the C. cristatella extract, was found to inhibit the growth of P. tinctorius. This inhibition, however, d
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