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Journal articles on the topic 'Pressure myography'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Sanford, Joe, Rita Patterson, and Dan O. Popa. "Concurrent surface electromyography and force myography classification during times of prosthetic socket shift and user fatigue." Journal of Rehabilitation and Assistive Technologies Engineering 4 (January 2017): 205566831770873. http://dx.doi.org/10.1177/2055668317708731.

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Objective Surface electromyography has been a long-standing source of signals for control of powered prosthetic devices. By contrast, force myography is a more recent alternative to surface electromyography that has the potential to enhance reliability and avoid operational challenges of surface electromyography during use. In this paper, we report on experiments conducted to assess improvements in classification of surface electromyography signals through the addition of collocated force myography consisting of piezo-resistive sensors. Methods Force sensors detect intrasocket pressure changes

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2

Te Winkel, Jan, Quincy E. John, Brian D. Hosfield, et al. "Mesenchymal stem cells promote mesenteric vasodilation through hydrogen sulfide and endothelial nitric oxide." American Journal of Physiology-Gastrointestinal and Liver Physiology 317, no. 4 (2019): G441—G446. http://dx.doi.org/10.1152/ajpgi.00132.2019.

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Mesenteric ischemia is a devastating process that can result in intestinal necrosis. Mesenchymal stem cells (MSCs) are becoming a promising treatment modality. We hypothesized that 1) MSCs would promote vasodilation of mesenteric arterioles, 2) hydrogen sulfide (H2S) would be a critical paracrine factor of stem cell-mediated vasodilation, 3) mesenteric vasodilation would be impaired in the absence of endothelial nitric oxide synthase (eNOS) within the host tissue, and 4) MSCs would improve the resistin-to-adiponectin ratio in mesenteric vessels. H2S was measured with a specific fluorophore (7-

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3

van der Bruggen, M., K. Reesink, P. Spronck, et al. "IN-VITRO CHARACTERIZATION OF MOUSE CAROTID ARTERY MECHANICS BY DYNAMIC BIAXIAL PRESSURE-MYOGRAPHY." Journal of Hypertension 37 (July 2019): e37. http://dx.doi.org/10.1097/01.hjh.0000570732.21239.66.

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4

Møller, Sophie, Jens Christian Brings Jacobsen, Thomas H. Braunstein, Niels-Henrik Holstein-Rathlou, and Charlotte M. Sorensen. "Influence of connexin45 on renal autoregulation." American Journal of Physiology-Renal Physiology 318, no. 3 (2020): F732—F740. http://dx.doi.org/10.1152/ajprenal.00185.2019.

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Renal autoregulation is mediated by the myogenic response and tubuloglomerular feedback (TGF) working in concert to maintain renal blood flow and glomerular filtration rate despite fluctuations in renal perfusion pressure. Intercellular communication through gap junctions may play a role in renal autoregulation. We examine if one of the building blocks in gap junctions, connexin45 (Cx45), which is expressed in vascular smooth muscle cells, has an influence on renal autoregulatory efficiency. The isolated perfused juxtamedullary nephron preparation was used to measure afferent arteriolar diamet

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5

Hatton, Daniel C., Qi Yue, Justin Chapman, et al. "Blood pressure and mesenteric resistance arterial function after spaceflight." Journal of Applied Physiology 92, no. 1 (2002): 13–17. http://dx.doi.org/10.1152/jappl.2002.92.1.13.

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Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated ( P < 0.001) as was relaxation to acetylcholine ( P < 0.001) and sodium nitroprusside ( P < 0.05). At high concentrat

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6

Conde, M. Victoria, M. Carmen Gonzalez, Begoña Quintana-Villamandos, et al. "Liver growth factor treatment restores cell-extracellular matrix balance in resistance arteries and improves left ventricular hypertrophy in SHR." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 3 (2011): H1153—H1165. http://dx.doi.org/10.1152/ajpheart.00886.2010.

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Liver growth factor (LGF) is an endogenous albumin-bilirubin complex with antihypertensive effects in spontaneously hypertensive rats (SHR). We assessed the actions of LGF treatment on SHR mesenteric resistance and intramyocardial arteries (MRA and IMA, respectively), heart, and vascular smooth muscle cells (VSMC). SHR and Wistar-Kyoto (WKY) rats treated with vehicle or LGF (4.5 μg LGF/rat, 4 ip injections over 12 days) were used. Intra-arterial blood pressure was measured in anesthetized rats. The heart was weighted and paraffin-embedded. Proliferation, ploidy, and fibronectin deposition were

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Moni, Saila S., Rachel Kirschenbaum, Lizelle Comfort, et al. "370: Non-invasive Uterine Monitoring: Comparison of Electrical Uterine Myography (EUM) and Intrauterine Pressure Catheter (IUPC)." American Journal of Obstetrics and Gynecology 220, no. 1 (2019): S255. http://dx.doi.org/10.1016/j.ajog.2018.11.391.

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8

Smith, T. G., and M. J. Stokes. "Technical aspects of acoustic myography (AMG) of human skeletal muscle: contact pressure and force/AMG relationships." Journal of Neuroscience Methods 47, no. 1-2 (1993): 85–92. http://dx.doi.org/10.1016/0165-0270(93)90024-l.

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9

Haran, Gabi, Moshe D. Fejgin, and Tal Biron-Shental. "706: Electrical uterine myography (EUM) is as good as intra uterine pressure catheter (IUP) in measuring contractions." American Journal of Obstetrics and Gynecology 204, no. 1 (2011): S279. http://dx.doi.org/10.1016/j.ajog.2010.10.728.

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10

Lei, Guangtai, Shenyilang Zhang, Yinfeng Fang, Yuxi Wang, and Xuguang Zhang. "Investigation on the Sampling Frequency and Channel Number for Force Myography Based Hand Gesture Recognition." Sensors 21, no. 11 (2021): 3872. http://dx.doi.org/10.3390/s21113872.

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Force myography (FMG) is a method that uses pressure sensors to measure muscle contraction indirectly. Compared with the conventional approach utilizing myoelectric signals in hand gesture recognition, it is a valuable substitute. To achieve the aim of gesture recognition at minimum cost, it is necessary to study the minimum sampling frequency and the minimal number of channels. For purpose of investigating the effect of sampling frequency and the number of channels on the accuracy of gesture recognition, a hardware system that has 16 channels has been designed for capturing forearm FMG signal

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11

Castorena-Gonzalez, Jorge A., Min Li, and Michael J. Davis. "Effects of Elevated Downstream Pressure and the Role of Smooth Muscle Cell Coupling through Connexin45 on Lymphatic Pacemaking." Biomolecules 10, no. 10 (2020): 1424. http://dx.doi.org/10.3390/biom10101424.

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Lymphatic vessels rely on spontaneous lymphatic muscle cell (LMC) contractions and one-way intraluminal valves to efficiently pump lymph and return it into the bloodstream. Intraluminal pressure is known to regulate the contractile function of lymphatics, with pressure elevation leading to increased contraction frequency and decreased amplitude. Contractions are normally initiated by a dominant pacemaker and are highly entrained among strongly coupled LMCs. Previously, we found that connexin45 is the major connexin isoform mediating LMC-LMC electrical coupling. Lymphatics from mice lacking smo

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12

Briones, Ana M., Fabiano E. Xavier, Silvia M. Arribas, et al. "Alterations in structure and mechanics of resistance arteries from ouabain-induced hypertensive rats." American Journal of Physiology-Heart and Circulatory Physiology 291, no. 1 (2006): H193—H201. http://dx.doi.org/10.1152/ajpheart.00802.2005.

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We have previously described that chronic administration of ouabain induces hypertension and functional alterations in mesenteric resistance arteries. The aim of this study was to analyze whether ouabain treatment also alters the structural and mechanical properties of mesenteric resistance arteries. Wistar rats were treated for 5 wk with ouabain (8.0 μg/day sc). The vascular structure and mechanics of the third-order branches of the mesenteric artery were assessed with pressure myography and confocal microscopy. Total collagen content was determined by picrosirius red staining, collagen I/III

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13

Chien, Chen-Yen, Ting-Jui Wen, Yu-Hsiuan Cheng, Yi-Ting Tsai, Chih-Yao Chiang, and Chiang-Ting Chien. "Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats." Antioxidants 9, no. 8 (2020): 679. http://dx.doi.org/10.3390/antiox9080679.

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Diabetes exacerbates myocardial ischemia/reperfusion (IR) injury by incompletely understood mechanisms. We explored whether diabetes diminished BAG3/Bcl-2/Nrf-2/HO-1-mediated cardioprotection and overproduced oxidative stress contributing to exaggerated IR injury. Streptozotocin-induced diabetes enhanced hyperglycemia, cardiac NADPH oxidase p22/p67 expression, malondialdehyde amount and leukocyte infiltration, altered the mesenteric expression of 4-HNE, CaSR, p-eNOS and BAG3 and impaired microvascular reactivity to the vasoconstrictor/vasodilator by a wire myography. In response to myocardial

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14

COATS, P. "Myogenic, mechanical and structural characteristics of resistance arterioles from healthy and ischaemic subjects." Clinical Science 105, no. 6 (2003): 683–89. http://dx.doi.org/10.1042/cs20030203.

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In critical limb ischaemia (CLI), the ability to regulate regional blood flow in the diseased portion of the leg would appear to be severely compromised. Considering this, pressure-dependent myogenic and mechanical properties of resistance arterioles isolated from control subjects and from patients with CLI were studied. Using confocal microscopy and pressure myography, subcutaneous resistance arteriole structure and function were compared between subcutaneous arterioles isolated from healthy volunteers [control subcutaneous (CS)] and non-diseased proximal subcutaneous (PS; internal control) a

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15

Olver, T. Dylan, Zachary I. Grunewald, Thomas J. Jurrissen, et al. "Microvascular insulin resistance in skeletal muscle and brain occurs early in the development of juvenile obesity in pigs." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 314, no. 2 (2018): R252—R264. http://dx.doi.org/10.1152/ajpregu.00213.2017.

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Impaired microvascular insulin signaling may develop before overt indices of microvascular endothelial dysfunction and represent an early pathological feature of adolescent obesity. Using a translational porcine model of juvenile obesity, we tested the hypotheses that in the early stages of obesity development, impaired insulin signaling manifests in skeletal muscle (triceps), brain (prefrontal cortex), and corresponding vasculatures, and that depressed insulin-induced vasodilation is reversible with acute inhibition of protein kinase Cβ (PKCβ). Juvenile Ossabaw miniature swine (3.5 mo of age)

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16

Hayoz, Sebastien, Jessica Pettis, Vanessa Bradley, Steven S. Segal, and William F. Jackson. "Increased amplitude of inward rectifier K+ currents with advanced age in smooth muscle cells of murine superior epigastric arteries." American Journal of Physiology-Heart and Circulatory Physiology 312, no. 6 (2017): H1203—H1214. http://dx.doi.org/10.1152/ajpheart.00679.2016.

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Inward rectifier K+ channels (KIR) may contribute to skeletal muscle blood flow regulation and adapt to advanced age. Using mouse abdominal wall superior epigastric arteries (SEAs) from either young (3–6 mo) or old (24–26 mo) male C57BL/6 mice, we investigated whether SEA smooth muscle cells (SMCs) express functional KIR channels and how aging may affect KIR function. Freshly dissected SEAs were either enzymatically dissociated to isolate SMCs for electrophysiological recording (perforated patch) and mRNA expression or used intact for pressure myography. With 5 mM extracellular K+ concentratio

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17

Greenstein, Adam S., Sharifah Zamiah Abdul Syed Kadir, Viktoria Csato, et al. "Disruption of Pressure-Induced Ca 2+ Spark Vasoregulation of Resistance Arteries, Rather Than Endothelial Dysfunction, Underlies Obesity-Related Hypertension." Hypertension 75, no. 2 (2020): 539–48. http://dx.doi.org/10.1161/hypertensionaha.119.13540.

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Obesity-related hypertension is one of the world’s leading causes of death and yet little is understood as to how it develops. As a result, effective targeted therapies are lacking and pharmacological treatment is unfocused. To investigate underlying microvascular mechanisms, we studied small artery dysfunction in a high fat–fed mouse model of obesity. Pressure-induced constriction and responses to endothelial and vascular smooth muscle agonists were studied using myography; the corresponding intracellular Ca 2+ signaling pathways were examined using confocal microscopy. Principally, we observ

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18

Enouri, Saad, Gabrielle Monteith, and Ron Johnson. "Characteristics of myogenic reactivity in isolated rat mesenteric veins." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300, no. 2 (2011): R470—R478. http://dx.doi.org/10.1152/ajpregu.00491.2010.

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Mechanisms of mechanically induced venous tone and its interaction with the endothelium and key vasoactive neurohormones are not well established. We investigated the contribution of the endothelium, l-type voltage-operated calcium channels (l-VOCCs), and PKC and Rho kinase to myogenic reactivity in mesenteric vessels exposed to increasing transmural pressure. The interaction of myogenic reactivity with norepinephrine (NE) and endothelin-1 (ET-1) was also investigated. Pressure myography was used to study isolated, cannulated, third-order rat mesenteric small veins and arteries. NE and ET-1 co

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19

Schepelmann, M., P. L. Yarova, I. Lopez-Fernandez, et al. "The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure." American Journal of Physiology-Cell Physiology 310, no. 3 (2016): C193—C204. http://dx.doi.org/10.1152/ajpcell.00248.2015.

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The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its role is not completely understood. In this study, we tested the hypothesis that the CaSR expressed in vascular smooth muscle cells (VSMC) is directly involved in regulation of blood pressure and blood vessel tone. Mice with targeted CaSR gene ablation from vascular smooth muscle cells (VSMC) were generated by breeding exon 7 LoxP-CaSR mice with animals in which Cre recombinase is driven by a SM22α promoter (SM22α-Cre). Wire myography performed on Cre-negative [wild-type (WT)] and Cre-positive SM22αCaSRΔflox

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20

Butlin, Mark, George Lindesay, Kayla D. Viegas, and Alberto P. Avolio. "Pressure dependency of aortic pulse wave velocity in vivo is not affected by vasoactive substances that alter aortic wall tension ex vivo." American Journal of Physiology-Heart and Circulatory Physiology 308, no. 10 (2015): H1221—H1228. http://dx.doi.org/10.1152/ajpheart.00536.2014.

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Aortic stiffness, a predictive parameter in cardiovascular medicine, is blood pressure dependent and experimentally requires isobaric measurement for meaningful comparison. Vasoactive drug administration to change peripheral resistance and blood pressure allows such isobaric comparison but may alter large conduit artery wall tension, directly changing aortic stiffness. This study quantifies effects of sodium nitroprusside (SNP, vasodilator) and phenylephrine (PE, vasoconstrictor) on aortic stiffness measured by aortic pulse wave velocity (aPWV) assessed by invasive pressure catheterization in

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21

Gutiérrez-Arzapalo, Perla Y., Pilar Rodríguez-Rodríguez, David Ramiro-Cortijo, et al. "Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension." Biomedicines 8, no. 10 (2020): 424. http://dx.doi.org/10.3390/biomedicines8100424.

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Fetal undernutrition programs hypertension and cardiovascular diseases, and resistance artery remodeling may be a contributing factor. We aimed to assess if fetal undernutrition induces resistance artery remodeling and the relationship with hypertension. Sprague–Dawley dams were fed ad libitum (Control) or with 50% of control intake between days 11 and 21 of gestation (maternal undernutrition, MUN). In six-month-old male and female offspring we assessed blood pressure (anesthetized and tail-cuff); mesenteric resistance artery (MRA) structure and mechanics (pressure myography), cellular and int

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Lin, ChengCheng, XiaoYun Wu, YuLei Zhou, et al. "Maternal high-fat diet programs cerebrovascular remodeling in adult rat offspring." Journal of Cerebral Blood Flow & Metabolism 38, no. 11 (2017): 1954–67. http://dx.doi.org/10.1177/0271678x17731956.

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Maternal environmental factors such as diet have consequences on later health of the offspring. We found that maternal high-fat diet (HFD) exposure renders adult offspring brain more susceptible to ischemic injury. The present study was further to investigate whether HFD consumption during rat pregnancy and lactation influences the cerebral vasculature in adult male offspring. Besides the endothelial damage observed in the transmission electron microscopy, the MCAs of offspring from fat-fed dams fed with control diet (HFD/C) also displayed increased wall thickness and media/lumen ratio, sugges

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Lynch, F. M., C. Austin, A. M. Heagerty, and A. S. Izzard. "Adenosine and hypoxic dilation of rat coronary small arteries: roles of the ATP-sensitive potassium channel, endothelium, and nitric oxide." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 3 (2006): H1145—H1150. http://dx.doi.org/10.1152/ajpheart.00314.2005.

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The aims of the study were to examine the roles of the ATP-sensitive potassium (KATP) channel, the endothelium, and nitric oxide (NO) in the responses of rat coronary small arteries to adenosine and hypoxia. Segments of rat coronary vessel were investigated in vitro using pressure myography; all vessels studied developed stable spontaneous myogenic tone during equilibration. Glibenclamide (a KATP channel inhibitor) reversed pinacidil but not 2-deoxyglucose-induced dilation. Both adenosine and hypoxia dilated the vessels, and glibenclamide did not reverse these responses. Endothelial removal or

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Kuru, Oktay, Ümit Kemal Şentürk, Günnur Koçer, et al. "Effect of exercise training on resistance arteries in rats with chronic NOS inhibition." Journal of Applied Physiology 107, no. 3 (2009): 896–902. http://dx.doi.org/10.1152/japplphysiol.91180.2008.

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Regular exercise has blood pressure-lowering effects, as shown in different types of experimental hypertension models in rats, including the nitric oxide synthase (NOS) inhibition model. We aimed to investigate possible mechanisms implicated in the exercise effect by evaluating the vasoreactivity of resistance arteries. Exercise effects on agonist-induced vasodilatory responses and flow-mediated dilation were evaluated in vessel segments of the rat chronic NOS inhibition model. Normotensive and hypertensive rats were subjected to swimming exercise (1 h/day, 5 days/wk, 6 wk), while rats in othe

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Pinilla, Estéfano, Simon Comerma-Steffensen, Judit Prat-Duran, et al. "Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries." Hypertension 77, no. 1 (2021): 216–27. http://dx.doi.org/10.1161/hypertensionaha.120.15352.

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Transglutaminase 2 (TG2) is an enzyme which in the open conformation exerts transamidase activity, leading to protein cross-linking and fibrosis. In the closed conformation, TG2 participates in transmembrane signaling as a G protein. The unspecific transglutaminase inhibitor cystamine causes vasorelaxation in rat resistance arteries. However, the role of TG2 conformation in vascular function is unknown. We investigated the vascular effects of selective TG2 inhibitors by myography in isolated rat mesenteric and human subcutaneous resistance arteries, patch-clamp studies on vascular smooth muscl

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Quek, Ko Jin, Omar Z. Ameer, and Jacqueline K. Phillips. "Amlodipine Improves Vessel Function and Remodeling in the Lewis Polycystic Kidney Rat Mesenteric Artery." American Journal of Hypertension 33, no. 7 (2020): 634–43. http://dx.doi.org/10.1093/ajh/hpaa054.

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Abstract BACKGROUND Hypertension is a common comorbidity associated with chronic kidney disease (CKD). Treatment in these patients often involves L-type Ca2+ channel (LTCC) blockers. The effect of chronic LTCC-blockade treatment on resistance vasculature was investigated in a genetic hypertensive rat model of CKD, the Lewis Polycystic Kidney (LPK) rat. METHODS Mixed-sex LPK and Lewis control rats (total n = 38) were allocated to treated (amlodipine 20 mg/kg/day p.o. from 4 to 18 weeks) and vehicle groups. Following systolic blood pressure and renal function assessment, animals were euthanized

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Torrens, Christopher, Lucilla Poston, and Mark A. Hanson. "Transmission of raised blood pressure and endothelial dysfunction to the F2generation induced by maternal protein restriction in the F0, in the absence of dietary challenge in the F1generation." British Journal of Nutrition 100, no. 4 (2008): 760–66. http://dx.doi.org/10.1017/s0007114508921747.

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We have previously demonstrated that maternal protein restriction during pregnancy leads to raised blood pressure and endothelial dysfunction in the offspring (F1). Here we show that these characteristics are transmitted to the F2offspring through the maternal line, in the absence of any additional challenges to the F1. Female Wistar rats were fed either a control (18 % casein) or protein-restricted diet (PR; 9 % casein) throughout pregnancy. Female F1offspring, maintained on standard chow postpartum, were mated with breeding males to produce F2progeny. Systolic blood pressure (SBP) in male F2

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Natarajan, Niranjana, Daijiro Hori, Sheila Flavahan, et al. "Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41." Physiological Genomics 48, no. 11 (2016): 826–34. http://dx.doi.org/10.1152/physiolgenomics.00089.2016.

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Short chain fatty acid (SCFA) metabolites are byproducts of gut microbial metabolism that are known to affect host physiology via host G protein-coupled receptor (GPCRs). We previously showed that an acute SCFA bolus decreases blood pressure (BP) in anesthetized mice, an effect mediated primarily via Gpr41. In this study, our aims were to identify the cellular localization of Gpr41 and to determine its role in BP regulation. We localized Gpr41 to the vascular endothelium using RT-PCR: Gpr41 is detected in intact vessels (with endothelium) but is absent from denuded vessels (without endothelium

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Zawieja, Scott D., Jorge A. Castorena-Gonzalez, Joshua P. Scallan, and Michael J. Davis. "Differences in L-type Ca2+ channel activity partially underlie the regional dichotomy in pumping behavior by murine peripheral and visceral lymphatic vessels." American Journal of Physiology-Heart and Circulatory Physiology 314, no. 5 (2018): H991—H1010. http://dx.doi.org/10.1152/ajpheart.00499.2017.

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We identified a regional dichotomy in murine lymphatic contractile function with regard to vessel location within the periphery or visceral cavity. All vessels isolated from peripheral regions [cervical, popliteal, inguinal, axillary, and internodal inguinal axillary (Ing-Ax)] developed robust contractions with maximal ejection fractions (EFs) of 50–80% in our ex vivo isobaric myograph experiments. Conversely, vessels isolated from the visceral cavity (mesenteric, thoracic duct, and iliac) demonstrated maximal EFs of ≤10%. Using pressure myography, sharp electrode membrane potential recordings

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Thakore, Pratish, Harry A. T. Pritchard, Caoimhin S. Griffin, et al. "TRPML1 channels initiate Ca2+ sparks in vascular smooth muscle cells." Science Signaling 13, no. 637 (2020): eaba1015. http://dx.doi.org/10.1126/scisignal.aba1015.

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TRPML1 (transient receptor potential mucolipin 1) is a Ca2+-permeable, nonselective cation channel localized to the membranes of endosomes and lysosomes and is not present or functional on the plasma membrane. Ca2+ released from endosomes and lysosomes into the cytosol through TRPML1 channels is vital for trafficking, acidification, and other basic functions of these organelles. Here, we investigated the function of TRPML1 channels in fully differentiated contractile vascular smooth muscle cells (SMCs). In live-cell confocal imaging studies, we found that most endosomes and lysosomes in freshl

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Shelton, Elaine L., Hai-Chun Yang, Jianyong Zhong, Michele M. Salzman, and Valentina Kon. "Renal lymphatic vessel dynamics." American Journal of Physiology-Renal Physiology 319, no. 6 (2020): F1027—F1036. http://dx.doi.org/10.1152/ajprenal.00322.2020.

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Similar to other organs, renal lymphatics remove excess fluid, solutes, and macromolecules from the renal interstitium. Given the kidney’s unique role in maintaining body fluid homeostasis, renal lymphatics may be critical in this process. However, little is known regarding the pathways involved in renal lymphatic vessel function, and there are no studies on the effects of drugs targeting impaired interstitial clearance, such as diuretics. Using pressure myography, we showed that renal lymphatic collecting vessels are sensitive to changes in transmural pressure and have an optimal range of eff

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Lindgren, Isa, Dane Crossley, Eduardo Villamor та Jordi Altimiras. "Hypotension in the chronically hypoxic chicken embryo is related to the β-adrenergic response of chorioallantoic and femoral arteries and not to bradycardia". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 301, № 4 (2011): R1161—R1168. http://dx.doi.org/10.1152/ajpregu.00458.2010.

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Prolonged fetal hypoxia leads to growth restriction and can cause detrimental prenatal and postnatal alterations. The embryonic chicken is a valuable model to study the effects of prenatal hypoxia, but little is known about its long-term effects on cardiovascular regulation. We hypothesized that chicken embryos incubated under chronic hypoxia would be hypotensive due to bradycardia and βAR-mediated relaxation of the systemic and/or the chorioallantoic (CA) arteries. We investigated heart rate, blood pressure, and plasma catecholamine levels in 19-day chicken embryos (total incubation 21 days)

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Tacey, Alexander, Cassandra Smith, Mary N. Woessner, et al. "Undercarboxylated osteocalcin is associated with vascular function in female older adults but does not influence vascular function in male rabbit carotid artery ex vivo." PLOS ONE 15, no. 11 (2020): e0242774. http://dx.doi.org/10.1371/journal.pone.0242774.

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Background There are conflicting reports on the association of undercarboxylated osteocalcin (ucOC) in cardiovascular disease development, including endothelial function and hypertension. We tested whether ucOC is related to blood pressure and endothelial function in older adults, and if ucOC directly affects endothelial-mediated vasodilation in the carotid artery of rabbits. Methods In older adults, ucOC, blood pressure, pulse wave velocity (PWV) and brachial artery flow-mediated dilation (BAFMD) were measured (n = 38, 26 post-menopausal women and 12 men, mean age 73 ± 0.96). The vasoactivity

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Satoh, Taijyu, Longfei Wang, Cristina Espinosa-Diez, et al. "Metabolic Syndrome Mediates ROS-miR-193b-NFYA–Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction." Circulation 144, no. 8 (2021): 615–37. http://dx.doi.org/10.1161/circulationaha.121.053889.

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Background: Many patients with heart failure with preserved ejection fraction have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in pulmonary vascular resistance in patients with heart failure with preserved ejection fraction portend a poor prognosis; this phenotype is referred to as combined precapillary and postcapillary pulmonary hypertension (CpcPH). Therapeutic trials for EIPH and CpcPH have been disappointing, suggesting the need for strategies that target upstream mechanisms of disease. This work reports novel rat EIPH models and mechanisms of

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Diaz-Otero, Janice M., Hannah Garver, Gregory D. Fink, William F. Jackson, and Anne M. Dorrance. "Aging is associated with changes to the biomechanical properties of the posterior cerebral artery and parenchymal arterioles." American Journal of Physiology-Heart and Circulatory Physiology 310, no. 3 (2016): H365—H375. http://dx.doi.org/10.1152/ajpheart.00562.2015.

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Artery remodeling, described as a change in artery structure, may be responsible for the increased risk of cardiovascular disease with aging. Although the risk for stroke is known to increase with age, relatively young animals have been used in most stroke studies. Therefore, more information is needed on how aging alters the biomechanical properties of cerebral arteries. Posterior cerebral arteries (PCAs) and parenchymal arterioles (PAs) are important in controlling brain perfusion. We hypothesized that aged (22–24 mo old) C57bl/6 mice would have stiffer PCAs and PAs than young (3–5 mo old) m

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Dhawan, Vivek, Zoe L. S. Brookes, and Susan Kaufman. "Repeated pregnancies (multiparity) increases venous tone and reduces compliance." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 289, no. 1 (2005): R23—R28. http://dx.doi.org/10.1152/ajpregu.00034.2005.

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In humans, multiparity (repeated pregnancy) is associated with increased risk of cardiovascular disease. In rats, multiparity increases the pressor response to phenylephrine and to acute stress, due in part to changes in tone of the splanchnic arterial vasculature. Given that the venous system also changes during pregnancy, we studied the effects of multiparity on venous tone and compliance. Cardiovascular responses to volume loading (2 ml/100 g body wt), and mean circulatory filling pressure (MCFP, an index of venomotor tone) were measured in conscious, repeatedly bred (RB), and age-matched v

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Gradel, Anna K. J., Max Salomonsson, Charlotte M. Sørensen, Niels-Henrik Holstein-Rathlou, and Lars Jørn Jensen. "Long-term diet-induced hypertension in rats is associated with reduced expression and function of small artery SKCa, IKCa, and Kir2.1 channels." Clinical Science 132, no. 4 (2018): 461–74. http://dx.doi.org/10.1042/cs20171408.

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Abdominal obesity and/or a high intake of fructose may cause hypertension. K+ channels, Na/K-ATPase, and voltage-gated Ca2+ channels are crucial determinants of resistance artery tone and thus the control of blood pressure. Limited information is available on the role of K+ transporters in long-term diet-induced hypertension in rats. We hypothesized that a 28-week diet rich in fat, fructose, or both, will lead to changes in K+ transporter expression and function, which is associated with increased blood pressure and decreased arterial function. Male Sprague–Dawley (SD) rats received a diet con

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Bloksgaard, Maria, Thomas M. Leurgans, Bart Spronck, et al. "Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries." American Journal of Physiology-Heart and Circulatory Physiology 313, no. 1 (2017): H164—H178. http://dx.doi.org/10.1152/ajpheart.00110.2017.

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The impact of disease-related changes in the extracellular matrix (ECM) on the mechanical properties of human resistance arteries largely remains to be established. Resistance arteries from both pig and human parietal pericardium (PRA) display a different ECM microarchitecture compared with frequently used rodent mesenteric arteries. We hypothesized that the biaxial mechanics of PRA mirror pressure-induced changes in the ECM microarchitecture. This was tested using isolated pig PRA as a model system, integrating vital imaging, pressure myography, and mathematical modeling. Collagenase and elas

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Brookes, Zoë L. S., Lewis Ruff, Viralkumar S. Upadhyay, et al. "Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone." American Journal of Physiology-Heart and Circulatory Physiology 304, no. 1 (2013): H33—H41. http://dx.doi.org/10.1152/ajpheart.01102.2011.

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Patients with autosomal dominant polycystic kidney disease have a high prevalence of hypertension and structural vascular abnormalities, such as intracranial aneurysms. Hypertension can develop in childhood and often precedes a significant reduction in the glomerular filtration rate. The major aim of this study was to investigate whether a primary endothelial defect or a vascular smooth muscle (VSM) defect was present in murine polycystic kidney disease (Pkd)2 heterozygous mesenteric vessels before the development of renal failure or hypertension. Using pressure myography, we observed a marked

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El-Rahman, Rasha R. Abd, Osama F. Harraz, Suzanne E. Brett, et al. "Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development." American Journal of Physiology-Heart and Circulatory Physiology 304, no. 1 (2013): H58—H71. http://dx.doi.org/10.1152/ajpheart.00476.2012.

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L-type Ca2+ channels are broadly expressed in arterial smooth muscle cells, and their voltage-dependent properties are important in tone development. Recent studies have noted that these Ca2+ channels are not singularly expressed in vascular tissue and that other subtypes are likely present. In this study, we ascertained which voltage-gated Ca2+ channels are expressed in rat cerebral arterial smooth muscle and determined their contribution to the myogenic response. mRNA analysis revealed that the α1-subunit of L-type (Cav1.2) and T-type (Cav3.1 and Cav3.2) Ca2+ channels are present in isolated

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Novelli, Enrico M., Lynda Little-Ihrig, Heather E. Knupp, et al. "Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 316, no. 6 (2019): L1150—L1164. http://dx.doi.org/10.1152/ajplung.00302.2018.

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Pulmonary hypertension (PH) is a leading cause of death in sickle cell disease (SCD) patients. Hemolysis and oxidative stress contribute to SCD-associated PH. We have reported that the protein thrombospondin-1 (TSP1) is elevated in the plasma of patients with SCD and, by interacting with its receptor CD47, limits vasodilation of distal pulmonary arteries ex vivo. We hypothesized that the TSP1-CD47 interaction may promote PH in SCD. We found that TSP1 and CD47 are upregulated in the lungs of Berkeley (BERK) sickling (Sickle) mice and patients with SCD-associated PH. We then generated chimeric a

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Ansar, Saema, and Lars Edvinsson. "Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage." Journal of Neurosurgery 111, no. 5 (2009): 978–87. http://dx.doi.org/10.3171/2007.3.16738.

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Object Cerebral ischemia remains the key cause of disability and death in the late phase after subarachnoid hemorrhage (SAH), and its pathogenesis is still poorly understood. The purpose of this study was to examine whether the change in intracranial pressure or the extravasated blood causes the late cerebral ischemia and the upregulation of receptors or the cerebral vasoconstriction observed following SAH. Methods Rats were allocated to 1 of 3 experimental conditions: 1) cisternal injection of 250 μl blood (SAH Group), 2) cisternal injection of 250 μl NaCl (Saline Group), or 3) the same proce

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Pires, Paulo W., Curt T. Rogers, Jonathon L. McClain, Hannah S. Garver, Gregory D. Fink, and Anne M. Dorrance. "Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 1 (2011): H87—H97. http://dx.doi.org/10.1152/ajpheart.01206.2010.

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Matrix metalloproteases (MMPs) are a family of zinc peptidases involved in extracellular matrix turnover. There is evidence that increased MMP activity is involved in remodeling of resistance vessels in chronic hypertension. Thus we hypothesized that inhibition of MMP activity with doxycycline (DOX) would attenuate vascular remodeling. Six-week-old male stroke-prone spontaneously hypertensive rats (SHRSP) were treated with DOX (50 mg·kg−1·day−1 in the drinking water) for 6 wk. Untreated SHRSP were controls. Blood pressure was measured by telemetry during the last week. Middle cerebral artery (

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Sutton, Elizabeth F., Mary Gemmel, Judith Brands, Marcia J. Gallaher, and Robert W. Powers. "Paternal deficiency of complement component C1q leads to a preeclampsia-like pregnancy in wild-type female mice and vascular adaptations postpartum." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318, no. 6 (2020): R1047—R1057. http://dx.doi.org/10.1152/ajpregu.00353.2019.

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Preeclampsia is a spontaneously occurring, pregnancy-specific syndrome that is clinically diagnosed by new onset hypertension and proteinuria. Epidemiological evidence describes an association between a history of preeclampsia and increased risk for cardiovascular disease in later life; however, the mechanism(s) driving this relationship are unclear. Our study aims to leverage a novel preeclampsia-like mouse model, the C1q−/− model, to help elucidate the acute and persistent vascular changes during and following a preeclampsia-like pregnancy. Female C57BL/6J mice were mated to C1q−/− male mice

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Black, M. Jane, Kyungjoon Lim, Monika A. Zimanyi, et al. "Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309, no. 9 (2015): R1153—R1161. http://dx.doi.org/10.1152/ajpregu.00403.2014.

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Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesized that there would be differences in the age-related decline in renal function between male and female intrauterine growth-restricted rats. Early-life growth restriction was induced in rat offspring by administering a low-protein diet (LPD; 8.7% casein) to dams during pregnancy and lactation. Control dams were fed a normal-protein diet (NPD; 20% casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32- and 100-wk-old offspring. Mesenteric artery function was examined

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Xiong, Yuxin, Annayya R. Aroor, Francisco I. Ramirez-Perez, et al. "Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na+ channel." American Journal of Physiology-Renal Physiology 318, no. 5 (2020): F1220—F1228. http://dx.doi.org/10.1152/ajprenal.00517.2019.

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Consumption of a Western diet (WD) induces central aortic stiffening that contributes to the transmittance of pulsatile blood flow to end organs, including the kidney. Our recent work supports that endothelial epithelial Na+ channel (EnNaC) expression and activation enhances aortic endothelial cell stiffening through reductions in endothelial nitric oxide (NO) synthase (eNOS) and bioavailable NO that result in inflammatory and oxidant responses and perivascular fibrosis. However, the role that EnNaC activation has on endothelial responses in the renal circulation remains unknown. We hypothesiz

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Johansen, Niloufer J., Diana Tripovic, and James A. Brock. "Streptozotocin-induced diabetes differentially affects sympathetic innervation and control of plantar metatarsal and mesenteric arteries in the rat." American Journal of Physiology-Heart and Circulatory Physiology 304, no. 2 (2013): H215—H228. http://dx.doi.org/10.1152/ajpheart.00661.2012.

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In humans neural control of arterial vessels supplying skin in the extremities is particularly vulnerable to the effects of diabetes. Here the streptozotocin (STZ) rat model of type 1 diabetes was used to compare effects on neurovascular function in plantar metatarsal arteries (PMAs), which supply blood to skin of hind paw digits, with those in mesenteric arteries (MAs). Twelve weeks after STZ (60 mg/kg ip), wire myography was used to assess vascular function. In PMAs, lumen dimensions were unchanged but both nerve-evoked contractions and sensitivity to α1 (phenylephrine, methoxamine)- and α2

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Luttrell, Ian P., Mei Swee, Barry Starcher, William C. Parks, and Kanchan Chitaley. "Erectile dysfunction in the type II diabetic db/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 5 (2008): H2204—H2211. http://dx.doi.org/10.1152/ajpheart.00027.2008.

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The number of men with type II diabetes-associated erectile dysfunction (ED) continues to grow rapidly; however, the majority of basic science studies has examined mechanisms of ED in animal models of type I diabetes. In this study, we first establish an in vivo mouse model of type II diabetic ED using the leptin receptor mutated db/ db and wild-type control BKS mouse. Furthermore, we hypothesized that dual mechanistic impairments contribute to the impaired erectile function in the type II diabetic mouse, altered vasoreactivity, and venoocclusive disorder. In vivo erectile function was measure

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Candela, Joseph, Rui Wang, and Carl White. "Microvascular Endothelial Dysfunction in Obesity Is Driven by Macrophage-Dependent Hydrogen Sulfide Depletion." Arteriosclerosis, Thrombosis, and Vascular Biology 37, no. 5 (2017): 889–99. http://dx.doi.org/10.1161/atvbaha.117.309138.

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Objective— The function of perivascular adipose tissue as an anticontractile mediator in the microvasculature is lost during obesity. Obesity results in inflammation and recruitment of proinflammatory macrophages to the perivascular adipose tissue that is paralleled by depletion of the vasorelaxant signaling molecule hydrogen sulfide (H 2 S) in the vessel. The current objective was to assess the role of macrophages in determining vascular [H 2 S] and defining how this impinged on vasodilation. Approach and Results— Contractility and [H 2 S] were measured in mesenteric resistance arterioles fro

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Pires, Paulo W., Michelle N. Sullivan, Harry A. T. Pritchard, Jennifer J. Robinson, and Scott Earley. "Unitary TRPV3 channel Ca2+ influx events elicit endothelium-dependent dilation of cerebral parenchymal arterioles." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 12 (2015): H2031—H2041. http://dx.doi.org/10.1152/ajpheart.00140.2015.

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Cerebral parenchymal arterioles (PA) regulate blood flow between pial arteries on the surface of the brain and the deeper microcirculation. Regulation of PA contractility differs from that of pial arteries and is not completely understood. Here, we investigated the hypothesis that the Ca2+ permeable vanilloid transient receptor potential (TRPV) channel TRPV3 can mediate endothelium-dependent dilation of cerebral PA. Using total internal reflection fluorescence microscopy (TIRFM), we found that carvacrol, a monoterpenoid compound derived from oregano, increased the frequency of unitary Ca2+ inf

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