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Dissertations / Theses on the topic 'Prostate cancer; epigenetic modification'

Author: Grafiati

Published: 10 December 2022

Last updated: 31 July 2025

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1

Mohamed, M. "Epigenetic biomarkers in prostate cancer." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426926.

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2

Zhang, Qunshu. "Epigenetic Regulation of Apoptosis in Prostate Cancer." Diss., North Dakota State University, 2015. https://hdl.handle.net/10365/27614.

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Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 and suppresses gene expression by catalyzing histone H3 methylation on lysine 27. EZH2 is overexpressed in metastatic prostate cancer and has been shown to promote cell proliferation and metastasis. Here we show that EZH2 also suppresses prostate cancer apoptosis by coordinating the epigenetic silencing of two pro-apoptotic microRNAs, miR-205 and miR-31. We previously reported that miR-205 is silenced in prostate cancer through promoter methylation. In this study, we found that EZH2 suppresse

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3

Chinaranagari, Swathi. "Epigenetic Silencing of ID4 in Prostate Cancer: Mechanistic Insight." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2015. http://digitalcommons.auctr.edu/cauetds/13.

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Inhibitor of DNA binding/differentiation protein 4 (ID4) is a dominant negative regulator of basic helix loop helix (bHLH) family of transcription factors. ID4 shares the homology of HLH domain with other ID proteins (ID1, ID2, and ID3) and lack the basic DNA binding region. Evidence suggested that unlike ID1, ID2 and ID3, ID4 acts as a tumor suppressor in prostate cancer by attenuating cell proliferation and promoting apoptosis. Consistent with these observations ID4 is epigenetically silenced in DU145 prostate cancer cell line. In this study we investigated whether ID4 is also epigenetically

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4

Taurozzi, Alberto. "Genetic and epigenetic profiling of human prostate cancer cell subsets." Thesis, University of York, 2016. http://etheses.whiterose.ac.uk/17511/.

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Perturbation of androgen signalling drives progression of human prostate cancer (CaP) to castration-resistant prostate cancer (CRPC). Additionally, CaP is initiated and maintained by cancer stem cells (CSC)s which are analogous to normal prostate stem cells (SC)s. This study presents a qPCR assay to detect androgen receptor gene amplification (GAAR), which is the most common mechanism of castration resistance ( > 30%). Also, the epigenetic regulation and function of two SC-silenced genes with tumour-suppressive activity (Latexin (LXN) and Retinoic Acid Receptor Responder 1 (RARRES1)) were inte

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5

Ribarska, Teodora [Verfasser]. "Expression and epigenetic regulation of imprinted genes in prostate cancer / Teodora Ribarska." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2013. http://d-nb.info/1036727513/34.

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6

Kadio, Bernard. "A Calcium-Centered Socio-Ecological Model of Prostate Cancer Disparities: Preliminary Studies and Findings." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40685.

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Western studies have established that men from African descent are disproportionally affected by prostate cancer (PCa). Annual incidence rates in this population vary from 1.5 to 2 times when compared to their counterparts from other racial groups. They also record the worse outcomes in terms of prognosis. Additionally, with the rise of PCa in Subsaharan Africa, new cancer control policies and programs are increasingly demanded. Understanding therefore, factors that underpin racial inequality in distribution and especially why the disease preferentially niches in African males can help b

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7

ROSTI, VALENTINA. "Chromatin solubility as a novel determinant of epigenome dysfunction in prostate cancer." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/382306.

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Il carcinoma prostatico (PCa) è il secondo tumore maschile più ricorrente, spesso caratterizzato da un esito sfavorevole a causa della sua elevata eterogeneità clinica e molecolare e della sua frequente multifocalità. Sempre più grandi sforzi della ricerca epigenetica si concentrano nel rilevamento di nuovi biomarcatori in grado di migliorare la diagnosi e la prognosi del PCa. Tra i livelli epigenetici, l'architettura nucleare della cromatina rispetta regole precise che garantiscono il corretto funzionamento del genoma e il mantenimento dell'identità cellulare, e il suo rimodellamento è emers

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8

BANDINI, MARCO. "Development of a novel signature integrating clinical, imaging and epigenetic information to tailor pelvic nodal treatment in prostate cancer." Doctoral thesis, Università Vita-Salute San Raffaele, 2023. https://hdl.handle.net/20.500.11768/136959.

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Radical prostatectomy (RP) is a treatment option for men with localized prostate cancer. Extended pelvic lymph node dissection (ePLND) at the time of RP is recommended only in patients at risk of lymph node invasion (LNI), where a more accurate disease staging can tailor further adjuvant treatments. The risk of LNI is assessed through preoperative models, such as the Briganti nomograms, which are based on clinical features. They allow for sparing ePLND in a significant proportion of patients, but their accuracy is still suboptimal. Unfortunately, ePLND is associated with significant risks of c

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9

Gupta, Yukti Hari. "An investigation into BORIS expression in prostate cancer cells and its role in epigenetic regulation of the androgen receptor gene." Thesis, University of Essex, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.635911.

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BORIS, a paralogue of the transcription factor CTCF, is a member of the cancer-testis antigen family. BORIS is normally present in the testes; however, it is aberrantly expressed in various tumours and cell lines. The main aim of this study was to investigate BORIS expression in prostate cell lines and tumours, and the importance of BORIS in the regulation of genes in prostate cells, in particular, the androgen receptor CAR) gene, associated with the development of more aggressive prostate tumours.

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10

Rubino, M. "EPIGENETIC MODIFICATIONS ABOLISH THE EXPRESSION OF THE LONG PENTRAXIN PTX3 IN HUMAN TUMORS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/254345.

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PTX3 is a fluid-phase pattern recognition receptor that participates in innate immunity and inflammation by modulating complement activation, leukocyte recruitment, extracellular matrix deposition and angiogenesis. PTX3 is a biomarker of inflammatory conditions in different pathologies in humans, including acute myocardial infarction to autoimmune diseases, infections and cancer associated inflammation. Moreover, in vivo studies indicate that PTX3 is involved in cancer development, possibly by regulating inflammation. Several tumors lack PTX3 expression, such as human esophageal squamous cell

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11

COSTA, ALICE. "Dissecting the role of G9a/GLP histone methyltransferases in Platinum-resistant ovarian cancer." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2988156.

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Epithelial Ovarian Cancer (EOC) is the most aggressive gynecological malignancy, mainly due to the advanced stage at diagnosis and the development of drug-resistant recurrences. Epigenetic modifications, such as histone methylation/acetylation, are emerging as key regulators of tumor growth and response to therapies. To verify if they are also involved in the onset of drug re-sistance in EOC, we performed a high-throughput Epigenetic Modifiers (EMs)-based screening using four different models of EOC isogenic Platinum-Resistant (PT-Res) cells. The screening identified G9a/GLP histone methyltran

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12

Wu, Mengchu. "The Epigenetic Silencing of PMP24 During the Progression of Prostate Cancer from an Androgen-Dependent to Androgen-Independent State in the LNCAP Cell Model: a Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/209.

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One important objective of prostate cancer (PCa) research is to understand the molecular basis underlying the progression of these cancers from an androgen dependent to an androgen independent state. Hypermethylation of the promoter CpG islands is associated with the transcriptional silencing of specific gene sets in each tumor type and subtype. Transcriptional silencing of antitumor genes via CpG island hypermethylation could be a mechanism mediating PCa progression from an androgen-dependent to an androgen-independent state. Hypermethylation associated gene silencing has been reported for a

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13

Siouda, Maha. "Transcriptional regulation and epigenetic repression of the tumor suppressor DOK1 in viral- and non viral-related carcinogenesis." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10163.

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Le suppresseur de tumeur DOK1 (downstream of tyrosine kinases1) est une protéine régulatrice de voies de signalisation impliquées dans des processus cellulaires tel que la prolifération, la migration et l'apoptose. Le rôle suppresseur de tumeur de DOK1 a été démontré dans des modèles animaux. Les souris knock-out pour DOK1 présentent une forte susceptibilité de développer des leucémies, des tumeurs malignes hématologiques, des adénocarcinomes pulmonaires, ainsi que des sarcomes histiocytaires agressifs. En outre, nous avons rapporté précédemment que le gène DOK1 peut être muté et son expressio

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14

Perriaud, Laury. "Étude systémique des cibles génomiques de la methyl-CpG binding domain protein 2 (MBD2), un répresseur transcriptionnel dépendant de la méthylation de l'ADN : évolution de la distribution de MBD2 dans un modèle syngénique de progression tumorale mammaire." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00833153.

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Les protéines à " Methyl-CpG-binding domain " (MBD) jouent un rôle important dans l'interprétationde la méthylation de l'ADN conduisant à la répression transcriptionnelle via le recrutement decomplexes remodelant la chromatine. Dans les cancers, MBD2 jouerait un rôle essentiel dans la perted'expression des gènes hyperméthylés. Ainsi, MBD2 serait une cible potentielle pour rétablir, enpartie au moins, leur expression. Caractériser, à l'échelle du génome, la distribution de MBD2 et sesconséquences sur la répression transcriptionnelle au cours de la cancérogenèse est donc une étapeincontournable.

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15

Chiam, Karen HuiQin. "The role of epigenetic modifications in prostate tumourigenesis." Thesis, 2010. http://hdl.handle.net/2440/62617.

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Prostate cancer is the second-leading cause of cancer death in Australian men. Current therapies for advanced prostate cancer are not curative and most patients eventually develop castrate resistant prostate cancer. Epigenetic modifications are heritable and reversible biochemical changes of the chromatin that regulate gene expression and are important in prostate tumourigenesis. There is also evidence that excess foetal nutrition is associated with increased risk of developing prostate cancer. Hence, the aims of this thesis were to determine the involvement of epigenetic modifications in: the

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16

Martins, João Álvaro Barbosa. "Epigenetic regulation of micrornas in prostate cancer." Master's thesis, 2012. https://repositorio-aberto.up.pt/handle/10216/64998.

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17

Martins, João Álvaro Barbosa. "Epigenetic regulation of micrornas in prostate cancer." Dissertação, 2012. https://repositorio-aberto.up.pt/handle/10216/64998.

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18

Wilkinson, EJ. "Epigenetic mechanisms in prostate cancer metastasis to the bone." Thesis, 2022. https://eprints.utas.edu.au/47492/1/Wilkinson_whole_thesis.pdf.

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In Australia, cancer accounted for approximately 30% of registered deaths in 2016. Although the 5-year survival rate for cancer is more than 68%, once a primary solid tumour has metastasised the 5-year survival of the disease markedly declines. Prostate cancers primarily metastasise to the bone and five-year survival for those with secondary bone lesions is 3%. Globally, prostate cancer is the second most commonly diagnosed cancer and the fifth leading cause of cancer death among men, with more than 1.4 million new cases of prostate cancer and 375,304 associated deaths worldwide estimated in 2

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19

Guan-RongLai and 賴冠榮. "Epigenetic Mechanisms of Vitamin D Resistance in Prostate Cancer." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/n7s53a.

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20

Santos, Pedro Alexandre Álvares Bargão dos. "Which epigenetic and inflammation related biomarkers can identify clinically aggressive prostate cancer." Doctoral thesis, 2020. http://hdl.handle.net/10362/105510.

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ABSTRACT: Prostate cancer is a highly prevalent malignancy and a major cause of cancer-related morbidity and mortality. Radical prostatectomy technique remains the major treatment opbon for men with potenbal cure and life expectancy exceeding 10 years. In the very recent 2018 published follow-up of 29 years of SPG4 study (watchful waibng versus radical prostatectomy), men who did RP gained a mean of 2.9 years of life. One of the relevant issues about surgery is its influence in the oncologic prognosis of pabents, namely, the presence of posibve surgical margins and its impact in biochem

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21

Graça, Maria Inês Pinho dos Santos. "Impact of epigenetic modulators on the malignant phenotype of prostate cancer cells." Doctoral thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/84821.

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22

Graça, Maria Inês Pinho dos Santos. "Impact of epigenetic modulators on the malignant phenotype of prostate cancer cells." Tese, 2013. https://repositorio-aberto.up.pt/handle/10216/84821.

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23

(9732323), Elena Wild. "Protein Arginine Methyltransferase 5 in Castration-Resistant and Neuroendocrine Prostate Cancer." Thesis, 2020.

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Prostate cancer is one of the most frequently diagnosed cancers and the second leading cause of cancer-related deaths in male population. While localized prostate cancer can be successfully treated with surgery or radiation therapy, the metastatic disease has no curable options. Metastasis can be developed as a result of failed therapy of localized cancer or present at initial diagnosis. As metastasis is the most common cause of prostate cancer-related death, developing novel approaches and improving the efficiency of existing therapies for the metastatic prostate cancer treatment will signifi

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24

Ilic, Aleksandar. "Role of UCHL1 in regulating gene expression in prostate cancer cells." 2014. http://hdl.handle.net/1993/23912.

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Ubiquitin C-terminal hydrolase L1 (UCHL1) is a multifunctional protein primarily expressed in neuronal cells and involved in numerous cellular processes. UCHL1 has been linked with neurodegenerative diseases and a wide range of cancers but its specific role remains unknown. Previous UCHL1 knockdown studies have shown that UCHL1 controls the expression of pro- and anti-apoptotic genes as well as genes involved in cell cycle regulation but it is unknown how UCHL1 regulates these genes. We have shown that UCHL1 is cross-linked to DNA in DU145 but not in LNCaP or PC3 prostate cancer cells. There

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25

Lin, Tung-Yueh, and 林東岳. "Discovery and Modification of KDM4 Inhibitors in Castration-Resistant Prostate Cancer Treatment." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/zytbkf.

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26

Sousa, Inês Margarida Marques de. "Genetic and epigenetic mechanisms involved in regulation of STEAP1 gene expression in LNCaP prostate cancer cells." Master's thesis, 2016. http://hdl.handle.net/10400.6/6289.

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Prostate cancer is the second most frequently diagnosed type of cancer and the fifth leading cause of cancer death in men worldwide. Prostate carcinogenesis is characterized by progressive alterations in genetic and epigenetic mechanisms that deregulate gene expression. The Six Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) gene encodes a protein with six transmembrane domains. In normal tissues, STEAP1 expression is very low but is overexpressed in several human cancers, mainly in prostate cancer. Some studies have indicated that STEAP1 overexpression seems to promote cell growth

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27

"Modification of anticancer drug sensitivity of human prostate cancer cells by estrogen related compounds." 1998. http://library.cuhk.edu.hk/record=b5889640.

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by Cheung Tak Chi.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1998.<br>Includes bibliographical references (leaves 117-123).<br>Abstract also in Chinese.<br>Acknowledgeements --- p.i<br>Abbreviations --- p.ii<br>Abstract --- p.v<br>List of Figures --- p.viii<br>List of Tables --- p.xiv<br>Contents --- p.xv<br>Contents<br>Chapter 1. --- Introduction --- p.1<br>Chapter 1.1 --- Epidemiological Risk Factors --- p.1<br>Chapter 1.1.1 --- Age --- p.1<br>Chapter 1.1.2 --- Race --- p.2<br>Chapter 1.1.3 --- Environmental or Migratory Factor --- p.2<br>Chapter 1.1.4 --- Diet --- p.

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28

Liu, Li Yang. "Association of Tissue Promoter Methylation Levels of APC, RASSF1A, CYP26A1, and TBX15 with Prostate Cancer Progression." Thesis, 2012. http://hdl.handle.net/1807/33724.

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Aberrant promoter methylation is known to silence tumor-suppressor genes in prostate cancer. Using a quantitative real-time PCR assay(MethyLight), I determined promoter methylation levels of APC, RASSF1A, CYP26A1 and TBX15 in 219 radical prostatectomies diagnosed between 1998-2001, examined their correlation with clinicopathological follow-up data including Gleason Pattern(GP), Gleason Score(GS) and pathological stage, and explored their potential in predicting biochemical recurrence(BR) using univariate and multivariate analyses. I demonstrated that methylation status of all four genes could

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29

Lin, Feng-YI, and 林峰益. "The mechanisms of thapsigargininhibit telomerase activity and induce cell death via epigenetic modification in lung cancer cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/71285797003911440815.

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碩士<br>中山醫學大學<br>醫學研究所<br>102<br>Thapsigargin (TG) was isolated from the Mediterranean plant Thapsia garganica. The highly lipophilic characteristic of TG accounts for their excellent penetration of biological membranes. TG can induce ER Stress and increase intracellular calcium through inhibiting sarco-endoplasmic reticulum Ca2+-ATPases. It has been reported that TG induces apoptosis and autophagy. In our previous study, TG inhibits telomerase activity by decreasing hTERT expression in A549 cells. In this study, we investigated the effects of TG on cytotoxicity, cell senescence and epigenetic

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30

Silva, Tânia Soraia Vieira da. "The role of macroH2A1 in prostate carcinogenesis." Master's thesis, 2015. http://hdl.handle.net/1822/41235.

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Dissertação de mestrado em Genética Molecular<br>Prostate cancer (PCa) is the most common noncutaneous malignancy in men and the major cause of cancer-related morbidity and mortality worldwide. Due to genetic and epigenetic deregulations, prostate cancer is characteristically asymptomatic in early stages. Deeper understanding of this mechanisms strength the development of new and improved diagnostic and prognostic tools and, therefore, better treatment strategies. The shuffle of canonical histones, an epigenetic mechanism, is highly conserved among species and expression alterations of

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31

Dias, Diana Soraia Ferreira. "Internship Report and Monography entitled“Epigenetic therapy applied to cancer – new challenges in biomedicine”." Master's thesis, 2021. http://hdl.handle.net/10316/98999.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Epigenetics comprises the study modifications in gene expression patterns that do not alter the primary DNA sequence, involving the reversible chemical modification of DNA, RNA and histones. Epigenetic changes are regulated by sets of enzymes that add or remove specific epigenetic markers and alter the expression of associated genes, producing an epigenetic code. Chromatin has several independent epigenetic mechanisms involved in modifying its structure, among which DNA methylation, post

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32

(8612079), Arpita S. Pal. "Identification of novel epigenetic mediators of erlotinib resistance in non-small cell lung cancer." Thesis, 2020.

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<p>Lung cancer is the third most prevalent cancer in the world; however it is the leading cause of cancer related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for ~85% of the lung cancer cases. The current strategies to treat NSCLC patients with frequent causal genetic mutations is through targeted therapeutics. Approximately 10-35% of NSCLC patient tumors have activated mutations in the Epidermal Growth Factor Receptor (EGFR) resulting in uncontrolled cellular proliferation. The standard-of care for such patients is EGFR-Tyrosine Kinase Inhibitors (EGFR-TKIs), a class of targ

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33

Winger, Joseph G. "Diet and exercise intervention adherence and health-related outcomes among older long-term breast, prostate, and colorectal cancer survivors." Thesis, 2013. http://hdl.handle.net/1805/5068.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Given the numerous benefits of a healthy diet and exercise for cancer survivors, there has been an increase in the number of lifestyle intervention trials for this population in recent years. However, the extent to which adherence to a diet and exercise intervention predicts health-related outcomes among cancer survivors is currently unknown. To address this question, data from the Reach out to ENhancE Wellness in Older Cancer Survivors (RENEW) diet and exercise intervention trial were analyzed. RENEW was a yearlong telephone and mai

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