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Dissertations / Theses on the topic 'PRR Signaling'

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Published: 6 September 2023

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1

Claverie, Justine. "Identification du xyloglucane comme nouvel éliciteur oligosaccharidique stimulant l’immunité de Vitis vinifera et d’Arabidopsis thaliana et caractérisation de deux récepteurs aux chito-oligosaccharides chez la vigne (VvLYK1-1 et VvLYK1-2)." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCK076/document.

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L’activation des réponses immunitaires des plantes repose sur la reconnaissance de motifs moléculaires associés aux pathogènes (aussi appelés PAMP) par des récepteurs de l’immunité, également nommés PRR (pattern recognition receptors). La chitine, principal composant de la paroi des champignons, est un PAMP bien caractérisé qui induit des réponses de défense aussi bien chez les mammifères que chez les plantes.La première partie de cette étude met en évidence que deux chito-oligosaccharides, la chitine et le chitosan, agissent comme des PAMP chez la vigne (Vitis vinifera) puisqu’ils induisent d
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2

Czechowski, Tomasz. "Nitrogen signalling in Arabidopsis thaliana." Phd thesis, [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975976095.

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3

McDonald, Sarah E. "Steroid pre-receptor signalling in human endometrium." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/24938.

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This work has shown that 11βHSD-1 mRNA is present at highest levels in the menstrual phase of the cycle and in first trimester deciduas, the times when an inflammatory response is evident. 11βHSD-2 mRNA and protein are present at all stages of the cycle, and also in first trimester deciduas. GR mRNA and protein are highly expressed throughout the cycle. MR mRNA expression varies across the cycle in a pattern similar to progesterone expression. 11βHSD-1 mRNA expression is increased in response to IL-1α and cortisol, and GR mRNA shows a similar trend. 11βHSD-1 and MR expression are not altered b
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4

McKenzie, Maxine. "Akt signalling in the human parasite 'Schistosoma mansoni'." Thesis, Kingston University, 2017. http://eprints.kingston.ac.uk/41116/.

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The study of cell signalling in schistosomes is crucial in deepening our knowledge of the biology of these blood flukes, which affect hundreds of millions of people worldwide. Here, Akt/protein kinase B (PKB) signalling has been functionally characterised and mapped in Schistosoma mansoni; an Akt variant of approximately 52 kDa has been characterised and RNA interference of the S. mansoni Akt gene, resulted in an 84% reduction in Akt expression. The phosphorylation (activation) status of the characterised Akt protein was increased by host molecules, including insulin and L-arginine in somules
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5

Groves, Tim C. "Pre-TCR and TCR-Ãß signaling during T cell development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ27657.pdf.

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6

Wang, Fang. "The Role of Acinus in Retinoic Acid Signaling Pathway." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/277479.

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Biochemistry<br>Ph.D.<br>Retinoic acid receptor (RAR), a member of the steroid/thyroid hormone nuclear receptor superfamily, functions as a RA-dependent transcription activator bound to the RA response element (RARE) within the promoter or enhancer region of target genes. The transcriptional activity of RAR is modulated by a large number of coregulators including coactivators and corepressors. Acinus is a nuclear protein with three isoforms (Acinus-L, Acinus-S and Acinus-S'). Acinus-S' interacts with the A/B domain of RAR and represses RAR-regulated genes expression. Acinus (without isoform de
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7

Bhangu, P. S. "Vesicular 'pre-synaptic' glutamatergic signalling mechanisms in bone." Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288814.

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8

Krjukova, Jelena. "Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4300.

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Communication between neuronal and non-neuronal is called volume transmission when the released neurotransmitter (NT) acts via diffusion and affects several target cells. Both the neurosecretory and postsynaptic cell responses are linked to [Ca2+]i elevations. In the present thesis the role of pre-and postsynaptic Ca2+ elevations has been investigated in the reconstituted "synapse" model comprised of NGF-differentiated PC12 and HEL cells as well as in SH-SY5Y neuroblastoma cells. In PC12 cells, both 70mM K+ and nicotine triggered NT release, which could be detected as a secondary [Ca2+]i incr
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9

Simón, Moya Miguel. "Unveiling the role of Phytochrome Interacting Factor 1 (PIF1) homologs in tomato." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670860.

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La llum és un dels senyals ambientals més importants que influeixen en el cicle de vida de la planta. Les plantes han desenvolupat un conjunt de complexos mecanismes moleculars que detecten canvis en la qualitat i quantitat de la llum. Els PHYTOCHROME INTERACTING FACTORS (PIFs) són factors de transcripció que interactuen amb els fotoreceptors fitocroms (phy) i intervenen les respostes a llum vermella / vermella llunyana. Els PIF estan involucrats en la regulació d'una àmplia gamma de processos de desenvolupament. S'han estudiat àmpliament en Arabidopsis thaliana, però se sap molt poc sobre el
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10

Macfarlane, Scott Robert. "Proteinase-activated receptor-2 mediated signalling in a human keratinocyte cell line." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366849.

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11

Thomas, Mélissa. "Etude de la voie non-apoptotique de CD95 et de l’implication du facteur d’initiation de la traduction eIF4A1." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1B048.

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Depuis sa découverte en 1991, l’implication du récepteur CD95 dans l’induction de l’apoptose a été plus que largement décrite. Mais bien qu'ayant été identifié comme étant un récepteur de mort, CD95 est aussi capable d'induire un signal pro-oncogénique lorsqu'il est fixé au CD95L clivé. L’activation de cette voie de signalisation non-apoptotique par le s-CD95L contribue au processus inflammatoire dans le lupus et à la dissémination métastatique dans les cancers du sein triples négatifs. Cependant aucun traitement thérapeutique satisfaisant n’est à ce jour disponible. De par son implication dan
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12

Bragdon, Beth Christie. "Membrane Regulation of Bone Morphogenetic Protein 2 Signaling in Pre-Osteoblastic Cells." Fogler Library, University of Maine, 2011. http://www.library.umaine.edu/theses/pdf/BragdonB2011.pdf.

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13

Ranganathan, Padhma. "Reciprocal regulation of Par-4 and caspase-8 in theTRAIL signaling pathway." Lexington, Ky. : [University of Kentucky Libraries], 2008. http://hdl.handle.net/10225/961.

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Thesis (Ph. D.)--University of Kentucky, 2008.<br>Title from document title page (viewed on January 29, 2009). Document formatted into pages; contains: x, 118 p. : ill. (some col.). Includes abstract and vita. Includes bibliographical references (p. 104-116).
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14

Hicks, Mellissa. "Signaling Networks as Possible Therapeutic Implications in Breast Cancer." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405945861.

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15

Leonardi, Anthony Joseph. "Cell to cell signaling via AKT causes T cell differentiation and collapse of tumour stroma." Thesis, Kingston University, 2018. http://eprints.kingston.ac.uk/41981/.

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Adoptive Cell Therapy of cancer using T cells is entering mainstream practice after years as a research method. Central to the efficacy of this “living therapy” is the function of the T cells transferred. T-cells, like other primary tissue cells, undergo differentiation and death. Clinical and preclinical data shows that lesser differentiated, less glycolytic, and more proliferative-capable cells used for the adoptive transfer yield superior tumor responses. This introductory section will describe discoveries which elucidate and control T-cell differentiation and function for the improvement o
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Ranganathan, Padhma. "RECIPROCAL REGULATION OF PAR-4 AND CASPASE-8 IN THE TRAIL SIGNALING PATHWAY." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/670.

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Par‐4 is a pro‐apoptotic tumor suppressor that is mutated, suppressed or inactivated in cancer. Par‐4 exploits components of the extrinsic pathway to cause apoptosis selectively of cancer cells. This study identified Par‐4 as an essential component of the apoptotic pathway induced by TRAIL, which selectively targets cancer cells. RNA interference‐mediated knockdown of Par‐4 rendered cancer cells unresponsive to TRAIL‐induced apoptosis. Cells with knocked‐down levels of Par‐4 were deficient in the activation of the apoptosis‐initiator caspase‐8 and the apoptosis‐effector caspase‐3 in response t
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17

Payne, Laura Beth. "Differential Impact of VEGF and FGF2 Signaling Mechanisms on Flt1 Pre-mRNA Splicing." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/81133.

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The human proteome is exponentially derived from a limited number of genes via alternative splicing, where one gene gives rise to multiple proteins. Alternatively spliced gene products, although crucial for normal physiology, are also linked to an increasing number of pathologies. Consequently, a growing focus is currently being placed on elucidating the extrinsic cues and ensuing signaling mechanisms which direct changes in gene splicing to yield functionally distinct proteins. Of note is the dysregulation of the vascular endothelial growth factor (VEGF) receptor, Flt1 and its soluble splice
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18

Benamar, Mehdi. "Modulation de la plasticité et des fonctions suppressives des lymphocytes T régulateurs par les molécules de signalisation Themis1 et Vav1." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30249.

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Les lymphocytes T régulateurs Foxp3+ jouent un rôle crucial dans l'établissement de la tolérance au soi, le contrôle des réponses inflammatoires et le maintien de l'homéostasie du système immunitaire. La compréhension des mécanismes moléculaires impliqués dans la fonction de ces cellules représente un défi important. Chez le rat, la déficience en Themis1, une nouvelle molécule de la signalisation du TCR, associée à un locus de 117kb d'origine BN induit un défaut fonctionnel des Tregs et le développement spontané d'une maladie inflammatoire des intestins. Au sein de ce locus, le rat BN présente
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19

Salari, Samira. "Mechanisms of Recombinant Heat Shock Protein 27 Atheroprotection: NF-κB Signaling in Macrophages". Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20725.

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The O’Brien lab has demonstrated that Heat shock protein 27 (HSP27)shows attenuated expression in human coronary arteries as the degree of atherosclerosis progresses. Moreover, over-expression of HSP27 reduces atherogenesis in mice. The precise mechanism(s) for HSP27-mediated "atheroprotection" are incompletely understood. Nuclear Factor-kappaB (NF-κB) is a key signaling modulator in atherogenesis. Hence, this project sought to determine if recombinant HSP27 (rHSP27) alters NF-κB signaling to affect atheroprotection. Treatment of THP1 macrophages with rHSP27 resulted in degradation of IκBα, co
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20

Ruez, Richard. "Mécanotransduction par les cavéoles : rôle dans l'activation de stat3 par l'interferon alpha." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112232.

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Hypothèse : Notre équipe étudie le rôle, mal connu, du trafic membranaire dans le contrôle de l’activation de la voie de signalisation JAK/STAT par les interférons (IFN), une voie clé du contrôle des processus cancéreux. La liaison de l’IFN-a à son récepteur IFNAR active les kinases JAK1 et TYK2 puis des transducteurs de signal comme STAT1, antiprolifératif, ou STAT3, qui a un pouvoir oncogénique. Le laboratoire a démontré récemment que le trafic membranaire d’IFNAR détermine la spécificité du signal des différents IFNs.L’objet de cette thèse est l’étude du rôle des cavéoles dans ce contrôle.
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21

Yoo, Ji Seung. "INVESTIGATIONS INTO THE ROLES OF PKR-INDUCED ANTIVIRAL STRESS GRANULE AND DHX36 IN RIG-I SIGNALING." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/189378.

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22

Krjukova, Jelena. "Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4300.

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23

Su, Ting-Cheng. "Regulation of pheromone response in saccharomyces by Ste12-PRE interaction and TOR-Cdc55 signaling." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43645.

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Ste12 is the key regulator in the yeast pheromone response pathway and works as an important model for understanding gene regulation by MAP kinase cascades. In this thesis I address how the binding strength of pheromone-response element (PRE) sequences, their orientation, and intervening nucleotide distance between two PREs govern the overall response to pheromone. I found that Ste12 binds as a monomer to a single PRE in vitro, and that two PREs upstream of a minimal core promoter cause a level of induction proportional to their relative affinity for Ste12 in vitro. Although consensus PREs are
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24

Devignes, Claire-Sophie. "Hypoxia signaling in osteoblast lineage cells promotes Systemic breast cancer growth and metastasis." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC325.

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La formation de métastases osseuses implique de nombreuses interactions entre les cellules de cancer du sein et le microenvironnement osseux. Les gradients d’hypoxie et l’activation de HIF (hypoxia inducible factor) 1alpha sont essentiels au maintien de l’homéostasie osseuse. Le rôle de la signalisation HIF dans les ostéoblastes lors du processus métastatique n’a pourtant jamais été exploré. Dans cette étude, nous montrons que les cellules ostéoprogénitrices (OPC), se situent dans des niches hypoxique, et que l’activation de la signalisation HIF dans ces cellules augmente la masse osseuse et f
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25

Minh, Vu Nhat. "Optimal Signaling Schemes and Capacities of Non-Coherent Correlated MISO Channels under Per-Antenna Power Constraints." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1533115867950851.

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26

Brown, Joanne Louise. "The role of the dsRNA dependent protein kinase (PKR) in cell signalling." Thesis, St George's, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391775.

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27

Sassonia, Rogerio Corte. "Caracterização termodinamica de reações de nitrosação e interações proteicas por titulação calorimetrica isotermica." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248521.

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Orientador: Marcelo Ganzarolli de Oliveira<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-15T02:21:46Z (GMT). No. of bitstreams: 1 Sassonia_RogerioCorte_D.pdf: 2947110 bytes, checksum: fc316c83bed9508d2e27063d89528d56 (MD5) Previous issue date: 2009<br>Resumo: Este trabalho apresenta os resultados da aplicação da titulação calorimétrica isotérmica na caracterização termodinâmica de reações de S-nitrosação de tióis e de interações proteínaproteína e proteína-íon. Foram estudadas as reações de S-nitrosação da N-acetil-L-cist
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Cheng, Jin [Verfasser]. "Precise somatotopic thalamocortical axon guidance depends on LPA-mediated PRG-2/Radixin signaling / Jin Cheng." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1124104542/34.

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Mariotti, J. "MODULAZIONE DEL SIGNALING DI STAT PER PREVENIRE IL RIGETTO DEL TRAPIANTO DI MIDOLLO OSSEO ALLOGENICO." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217168.

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Janus Kinase (JAK)/ Signal Transducer of Activated Transcription (STAT) signaling represents the main molecular pathway dictating T cell differentiation both in humans and in mice. Allogeneic hematopoietic stem cell transplantation (HSCT) is a potential curative strategy for patients with hematologic malignancies and its outcome depends on the interplay between host and donor immune system resulting in graft rejection (GR) or graft versus host disease (GVHD), respectively. We therefore proposed to investigate the role of JAK/STAT signaling in these two phenomena that are biologically considere
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Branco, Diana Santos 1983. "Sinalização por carboidratos em cana-de-açucar e divergencia evolutiva." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317165.

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Orientadores: Michel Georges Albert Vincentz, Juliana de Maria Felix<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-11T18:43:41Z (GMT). No. of bitstreams: 1 Branco_DianaSantos_M.pdf: 18385613 bytes, checksum: 43238e785391538d38599321de0ac5ca (MD5) Previous issue date: 2008<br>Resumo:Além de fonte primária de carbono e energia para os principais tipos celulares, os açúcares produzidos pela fotossíntese adquiriram importantes funções ao longo da evolução das plantas, no controle do crescimento e desenvolvimento, do me
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St-Pierre, David. "Mécanismes de signalisation d’AT1R médiés par des analogues cycliques de l’angiotensine II." Mémoire, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/11091.

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L'angiotensine II (Ang II) joue un rôle important dans la régulation du système cardiovasculaire par l’activation de plusieurs voies de signalisation. L’activation de ces voies passe par le récepteur de l'angiotensine II de type 1 (AT1R). Ce récepteur fait partie de la famille des récepteurs couplés aux protéines G (GPCRs). De plus, il est maintenant connu que certains ligands peuvent lier le récepteur et induire une conformation qui permet d'activer certaines voies de signalisation tout en n’étant pas favorable à l'activation d'autres voies. Il est alors question de sélectivité fonctionnelle,
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Kupittayanant, Sajeera. "The role of calcium and signalling pathways in the control and modulation of uterine contraction : with emphasis on human myometrium." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269569.

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Farabaugh, Kenneth Thomas kt. "Insights into a Novel Signaling Pathway that Determines Cell Fate in Response to Hyperosmotic Stress." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1571692276973131.

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Schwob, Aurélien. "Rôle des récepteurs de l'autophagie sélective dans la modulation de la signalisation NF- κB par l'oncoprotéine Tax du virus HTLV-1". Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN027/document.

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L’activation constitutive de la voie NF-κB est une étape cruciale dans le processus de transformation des lymphocytes T par le virus humain T-lymphotrope de type 1 (HTLV-1). La protéine virale Tax y joue un rôle majeur en recrutant la protéine régulatrice IKKγ. De précédents travaux effectués par notre équipe ont montré que l’activation de la voie NF-κB parTax est promue par le recrutement des facteurs celluaires Optineurine (OPTN) et Tax1-binding protein 1 (TAX1BP1), deux protéines récemment décrites comme des membres de la famille de récepteurs autophagiques Sequestosome-Like Receptors (SLR)
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Ortet, Cortada Laura. "Signalling of ciclyn o complexes through EIF2alpha phosphorylation." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7259.

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We have identified a novel Cyclin, called Cyclin O, which is able to bind and activate Cdk2 in response to intrinsic apoptotic stimuli. We have focused on the study of Cyclin O&#945; and Cyclin O&#946;, alternatively spliced products of the gene. Upon treatment with different stress stimuli, transfected Cyclin O&#945; accumulates in dense aggregations in the cytoplasm compatible with being Stress Granules (SGs). Furthermore, we have seen that Cyclin O&#946; and a point mutant of the N-terminal part of the protein constitutively localize to the SGs. Although both alpha and beta isoforms are pro
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Thakuri, Bal Krishna Chand. "SIP-428, a SIR2 Deacetylase Enzyme and Its Role in Biotic Stress Signaling Pathway." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3505.

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SABP2 (Salicylic Acid Binding Protein 2) plays a vital role in the salicylic acid signaling pathway of plants both regarding basal resistance and systemic acquired resistance against pathogen infection. SIP-428 (SABP2 Interacting Protein-428) is a Silent information regulator 2 (SIR2) like deacetylase enzyme that physically interacts with SABP2 in a yeast two-hybrid interaction and confirmed independently by a GST pull-down assay. We demonstrated that SIP- 428 is an NAD+ dependent SIR2 deacetylase enzyme. Transgenic tobacco plants silenced in SIP- 428 expression via RNAi showed enhanced basal
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Porchet, Nicolas. "Role of signaling pathays in cell-fate specification in the early mouse embryo." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7096.

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Lors du développement précoce de l’embryon de souris, divers évènements de spécification des destins cellulaires induisent la formation du blastocyste pré-implantatoire. Ces évènements sont majoritairement contrôlés par l’action de voies de signalisation activées via la fixation de molécules signal à la membrane de la cellule. L’activité de ces voies de signalisation permet la régulation de la transcription de gènes cible responsable de l’acquisition d’une identité cellulaire et de son arrangement sous forme de tissu. Ici je m’intéresse aux rôles des voies ACTIVINE/NODAL et βCATENIN dans la sp
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Naik, Shambhavi. "Characterisation of TRAIL receptor signalling to apoptosis in pre-clinical models of breast cancer." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9913.

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TNF-Related Apoptosis-Inducing Ligand (TRAIL) belongs to the TNF cytokine family and can signal to apoptosis by binding to either of two membrane-bound death receptors, TRAIL-R1 or TRAIL-R2. Using ligands specific for TRAIL-R1 (R1L) or TRAIL-R2 (R2L), our laboratory has previously shown that combining a histone deacetylase inhibitor with R1L, but not R2L, induces apoptosis in primary chronic lymphocytic leukaemia cells. The aim of this project was to extend the profiling of TRAIL-Receptor signalling to breast cancer, using breast cancer cell lines and importantly primary breast tumours as mode
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Santos, Geisa Aparecida dos. "Análise comparativa de perfis de sinalização do receptor AT1 ativado por agonistas seletivos para a via de -arrestinas." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-31102013-150124/.

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Os receptores acoplados à proteína G (GPCRs), também chamados de receptores 7TM, são conhecidos por regular virtualmente todos os processos fisiológicos em mamíferos e cerca de 40% de todas as drogas comerciais agem através destes receptores. A sinalização mediada por eles é classicamente atribuída à proteína G, que é ativada pela troca de GDP por GTP, promovendo a separação das subunidades G e G, e leva à produção de mensageiros secundários como cAMP, Ca2+ e DAG. Após a resposta os GPCRs são fosforilados pelas quinases de GPCRs (GRKs), sinalizando para recrutamento das -arrestinas citoplasmát
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Bajaj, Garima. "A Pre and Post 9-11 Analysis of SS7 Outages in the Public Switched Telephone Network." Ohio University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1171294573.

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Rolim, Natale Pinheiro Lage. "Efeito do treinamento físico em modelo genético de insuficiência cardíaca induzida por hiperatividade simpática." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/39/39132/tde-12112007-170402/.

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A atividade nervosa simpática está aumentada na insuficiência cardíaca (IC) e relacionada com a gravidade e o prognóstico da doença. Camundongos com deleção dos receptores adrenérgicos &#945;2A e &#945;2C (&#945;2A/&#945;2CARKO) desenvolvem IC induzida pela hiperestimulação simpática e apresentam 50% de mortalidade aos sete meses de idade. A diminuição na contratilidade cardíaca, a perda de cardiomiócitos e a intolerância à realização de esforço físico sugerem esse modelo genético para o estudo de possíveis terapias farmacológicas e não-farmacológicas para o tratamento da IC. O presente estudo
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42

Koetz, Clara Isabel. "A influência do afeto e do gênero do consumidor no processamento das informações de qualidade sinalizadas por meio da propaganda." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/31967.

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O objetivo desta tese consiste em analisar a influência do afeto e do gênero do consumidor na percepção da qualidade do produto nos processos de sinalização da qualidade por meio da propaganda. Para tal, dois estudos experimentais foram conduzidos. O primeiro estudo foi aplicado no Brasil, em uma amostra de 144 estudantes, no qual buscou-se analisar a influência do investimento em propaganda (abaixo da média, na média e acima da média praticada no mercado), do afetivo (positivo e negativo) e do gênero (masculino e feminino) na percepção da qualidade do produto. Na análise dos dados, foram cond
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43

Castellanos, jankiewicz Ashley. "Bile acids signaling as a novel mechanism in the hypothalamic control of energy balance." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0218.

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Introduction : Les acides biliaires (AB) sont des molécules connues pour digérer les lipides. En activant le récepteur couplé à la protéine G Takeda 5 (TGR5) dans les tissus périphériques, ils peuvent également servir de molécules de signalisation pour réduire le poids corporel et améliorer le profil glycémique. L'activation de TGR5 peut aussi augmenter la dépense énergétique dans le tissu adipeux, mais les voies métaboliques impliquées dans ces effets sont encore mal connues. Ces observations impliquent une action anti-obésité du TGR5. Cependant, toutes les études sur les AB dans la balance é
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44

McKenna, Mary Kathryn. "NOVEL ROLE OF PROSTATE APOPTOSIS RESPONSE-4 TUMOR SUPPRESSOR IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA." UKnowledge, 2017. https://uknowledge.uky.edu/microbio_etds/17.

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Chronic Lymphocytic Leukemia (CLL) is defined by the accumulation of clonally expanded CD5+ and CD19+ B lymphocytes in blood and secondary lymphoid organs with impaired apoptotic mechanisms. CLL represents one third of all leukemia cases with an average age of 72 years at diagnosis making it the most common adult leukemia. The Eµ-Tcl1 mouse serves as an excellent model to study the development of CLL as they progress to a CLL like disease by 9-14 months of age, due to overexpression of an oncogene, T cell Leukemia 1(Tcl1), specifically in B cells through the Ig VH promoter and Eµ enhancer (Bic
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45

Deng, Xiaoling. "Identification of PAR₁-G protein signalling pathways involved in thrombin-induced CCL2/MCP-1 production." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444265/.

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Uncontrolled activation of the coagulation cascade following lung injury has been implicated in both lung inflammation and fibrosis. In addition to its role in coagulation, thrombin exerts pluripotent cellular effects via the activation of its high-affinity receptor, proteinase activated receptor-1 (PAR_1). PAR_1 is a seven transmembrane domain G protein-coupled receptor that exhibits the ability to couple to multiple G protein family subunits, including G\alpha_{i/o}, G\alpha_q and G\alpha_{12/13} within the same cell type. Activation of PAR_1 on fibroblasts, a key effector cell in lung fibro
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46

McIntosh, Kathryn Ann. "Proteinase-activated receptor-2( PAR-2) and tumour necrosis factor-alpha ( TNFα) signalling in inflammation". Thesis, University of the West of England, Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489251.

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Proteinase activated receptor-2 (PAR-2) is a novel G-protein coupled receptor, that is activated by means of proteolytic cleavage (Macfarlane et al, 2001) and has both pro and anti-inflammatory actions depending upon the system examined. PAR-2 have been linked to the stress-activated protein kinases (SAPKs), JNK and p38 MAP kinase and NFK13 signalling (Kanke et al, 2001; Sabri et al, 2000), pathways known to be involved in proinflammatory responses in several cell types. TNFa has been demonstrated to up-regulate PAR-2 expression in a variety of cell types (Nystedt et al, 1996; Ritchie et al, 2
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47

Yamashita, Felipe Oliveira. "Memória fisiológica e comunicação radicular induzida por metil jasmonato." Botucatu, 2019. http://hdl.handle.net/11449/181889.

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Orientador: Luiz Fernando Rolim de Almeida<br>Resumo: Apesar de serem organismos sésseis, as plantas movimentam ativamente estruturas vegetativas e reprodutivas, levando a interação com o ambiente ao redor. As plantas mantêm comunicação com plantas vizinhas, herbívoros e predadores através da emissão de compostos químicos exsudados pela raiz e esses eventos modificam o ambiente ocupado pelos vegetais. Esses exsudatos podem induzir a alteração de padrões morfológicos e fisiológicos além da expressão gênica de plantas vizinhas. Utilizamos o metil jasmonato, um regulador vegetal, para desencadear
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48

Franco, Danilo Miralha. "Comunicação radicular induzida por diferentes tipos de substâncias químicas." Botucatu, 2017. http://hdl.handle.net/11449/151529.

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Orientador: Luiz Fernando Rolim de Almeida<br>Resumo: Devido à natureza séssil, os vegetais estão sujeitos a modificações no ambiente que podem levar a deficiência hídrica, atividade alelopática e herbicida, e necessitam de respostas especificas para responder a elas. As respostas são induzidas pelas modificações, e demandam tempo e energia para serem ativadas. A comunicação vegetal pode ter importante função de processamento de informação, sinalizando sobre um evento estressante de uma planta para outra. Essa sinalização pode otimizar a aptidão de aclimatação ao estresse ambiental. Portanto,
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49

Jancenelle, Vivien E. "Signaling Normative and Economic Orientations during Earnings Conference Calls: Market Performance Antecedents and Consequences." Cleveland State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=csu1488814095926987.

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50

Balsiger, Alexander 1975. "The Role of cyclin O in ER stress signalling." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/565441.

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We recently identified a novel cyclin called Cyclin O which is able to bind and activate Cdk1 and Cdk2 in response to intrinsic apoptotic stimuli like DNA damage or ER stress. Cyclin O has been shown to be involved in the unfolded protein response (UPR) as an activator of PERK signalling. The aim of this thesis has been to study the molecular role of Cyclin O in response to ER stress. We have found that expression of Cyclin O is upregulated upon ER stress by pathways of the UPR that signal through eIF2α phosphorylation and CHOP expression. Furthermore, we have observed that Cyclin O activates
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