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Academic literature on the topic 'Psoralène'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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Journal articles on the topic "Psoralène"

1

Salahou, A., C. Courseille, J. L. Decout, and J. Lhomme. "Structure d'un photoproduit psoralène–thymine: modèle pour l'interaction avec l'ADN sur le cycle pyrone du psoralène." Acta Crystallographica Section C Crystal Structure Communications 44, no. 12 (1988): 2167–70. http://dx.doi.org/10.1107/s010827018800856x.

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Diekmann, Janina, Isabell Theves, Kristoffer A. Thom, and Peter Gilch. "Tracing the Photoaddition of Pharmaceutical Psoralens to DNA." Molecules 25, no. 22 (2020): 5242. http://dx.doi.org/10.3390/molecules25225242.

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The psoralens 8-methoxypsoralen (8-MOP), 4,5′,8-trimethylpsoralen (TMP) and 5-methoxypsoralen (5-MOP) find clinical application in PUVA (psoralen + UVA) therapy. PUVA treats skin diseases like psoriasis and atopic eczema. Psoralens target the DNA of cells. Upon photo-excitation psoralens bind to the DNA base thymine. This photo-binding was studied using steady-state UV/Vis and IR spectroscopy as well as nanosecond transient UV/Vis absorption. The experiments show that the photo-addition of 8-MOP and TMP involve the psoralen triplet state and a biradical intermediate. 5-MOP forms a structurally different photo-product. Its formation could not be traced by the present spectroscopic technique.

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Jamalis, Joazaizulfazli, Faten Syahira Mohamed Yusof, Subhash Chander, et al. "Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties." Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 19, no. 3 (2020): 222–39. http://dx.doi.org/10.2174/1871523018666190625170802.

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Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic, photosensitizing, insecticidal, antibacterial to antifungal effect. Thus, several structural changes were introduced to explore the role of specific positions with respect to the biological activity. Convenient approaches utilized for the synthesis of psoralen skeleton can be categorized into two parts: (i) the preparation of the tricyclic ring system from resorcinol, (ii) the exocyclic modification of the intact ring system. Furthermore, although psoralens have been used in diverse ways, we mainly focus in this work on their clinical utility for the treatment of psioraisis, vitiligo and skin-related disorder.

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Da Silva, Vinicius Barreto, Daniel Fábio Kawano, Ivone Carvalho, Edemilson Cardoso Conceição, Osvaldo Freitas, and Carlos Henrique Tomich de Paula Silva. "Psoralen and Bergapten: In Silico Metabolism and Toxicophoric Analysis of Drugs Used to Treat Vitiligo." Journal of Pharmacy & Pharmaceutical Sciences 12, no. 3 (2009): 378. http://dx.doi.org/10.18433/j3w01d.

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PURPOSE: to discuss the contribution of psoralen and bergapten metabolites on psoralens toxicity. METHODS: Computational chemistry prediction of metabolic reactions and toxicophoric groups based on the expert systems Derek and Meteor. RESULTS: a total of 15 metabolites were suggested for both psoralen and bergapten based on phase 1 and 2 biotransformations until the 3rd generation. Five toxicophoric substructures were shared among psoralen, bergapten and their corresponding metabolites; one toxicophoric marker (resorcinol) was only identified in bergapten and its biotransformation products. CONCLUSION: Although the toxic effects of psoralens are well known and documented, there is little information concerning the role of their metabolites in this process. We believe this work add to the knowledge of which molecular substructures are relevant to the process of metabolism and toxicity induction, thus guiding the search and development of more effective and less toxic drugs to treat vitiligo.

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Chen, Yuling, Rong Wang, and Zilin Chen. "Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with a porphyrin-based porous organic polymer modified capillary." Analytical Methods 11, no. 1 (2019): 29–35. http://dx.doi.org/10.1039/c8ay01885e.

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Huseyn A. Abiyev та Khayala R. Mammadova. "Effects of α-tocopherol on phototoxicity of 8 - methoxypsoralene". Magna Scientia Advanced Biology and Pharmacy 2, № 1 (2021): 01–08. http://dx.doi.org/10.30574/msabp.2021.2.1.0005.

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Effects of singlet oxygen extinguisher α-tocopherol on combined effects of psoralens and UV on erythema photosensitized with 8-methoxypsoralene were investigated. The leading role of the reactions of photocompounds in induction of PUVA - erythema is considered. A characteristic feature of biologically active psoralens is the high value of quantum output of intercombination conversion, due to which, after absorption of light quants, a significant number of psoralen molecules are formed in a triplet excited state. Psoralen derivatives differ greatly in their ability to photosensitize the skin. In the example of 8-psoralens, a correlation was found between the ability to induce erythema by photocompound to double-spiral DNA in vitro. A clear correlation was identified between the ability to photosensitize erythema and form diadducts. Α-tocopherol has been shown to protect the skin from PUVA erythema if presents during irradiation. In the case of application of α-tocopherol after irradiation, the inhibitory effect was not exhibited.

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Thomas, D. C., D. L. Svoboda, J. M. Vos, and T. A. Kunkel. "Strand specificity of mutagenic bypass replication of DNA containing psoralen monoadducts in a human cell extract." Molecular and Cellular Biology 16, no. 5 (1996): 2537–44. http://dx.doi.org/10.1128/mcb.16.5.2537.

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Psoralens are mutagenic compounds of vegetable origin that are used as photosensitizing agents in the treatment of various skin diseases, blood cell cancer, and autoimmune disorders. To study the mechanism of mutagenicity of psoralens in humans, we examined the efficiency and fidelity of simian virus 40 origin-dependent replication in a human cell extract of M13mp2 DNA randomly treated with the psoralen derivative 4'-hydroxymethyl-4,5',8-trimethyl psoralen plus UVA irradiation. Replication of DNA treated with variable amounts of 4'-hydroxymethyl-4,5',8-trimethyl psoralen and a fixed UVA fluence was inhibited in a concentration-dependent manner. However, covalently closed monomer-length circular replication products were observed. Product analysis by renaturing agarose gel electrophoresis after cross-linking with 250- to 280-nm UV light indicated that approximately 1 of 9 psoralen monoadducts was bypassed during in vitro replication. Introduction of product DNA into Escherichia coli to score replication errors in the lacZalpha reporter gene demonstrated that replication of the damaged DNA was more mutagenic than was replication of undamaged DNA. Sequence analysis of lacZ mutants revealed that damage-dependent replication errors were predominantly T.A-->C.G transitions, transversions at C.G base pairs, and deletions of single A.T base pairs, the last occurring most frequently in homopolymeric runs. A comparison of error specificities with two substrates having the replication origin asymmetrically placed on opposite sides of the mutational target suggests that the lagging-strand replication apparatus is less accurate than the leading-strand replication apparatus for psoralen monoadduct-dependent deletion errors. A model is proposed based on the preferential loopout of the monoadducted base from the strand that templates retrograde discontinuous synthesis.

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Grass, Joshua A., Derek J. Hei, Ken Metchette, et al. "Inactivation of Leukocytes in Platelet Concentrates by Photochemical Treatment With Psoralen Plus UVA." Blood 91, no. 6 (1998): 2180–88. http://dx.doi.org/10.1182/blood.v91.6.2180.

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Abstract A photochemical treatment (PCT) process using a novel psoralen and long wavelength ultraviolet light (UVA, 320-400 nm) has been developed to inactivate bacteria and viruses in platelet concentrates. This study evaluated the efficacy of PCT for inactivation of leukocytes that contaminate platelet preparations. Three psoralens, 8-methoxypsoralen (8-MOP), 4′-aminomethyl 4,5′,8-trimethylpsoralen (AMT), and the novel psoralen S-59, were compared using the following four independent but complementary biological and molecular assays. (1) T-cell viability: Treatment with 150 μmol/L S-59 and 1.0 to 3.0 Joules/cm2 UVA inactivated >5.4 ± 0.3 log10 of T cells in full-sized single-donor plateletpheresis units. Using 1.0 Joule/cm2 UVA, the lowest dose of S-59, AMT and 8-MOP required to reduce the number of T cells to the limit of detection was 0.05 μmol/L, 1.0 μmol/L, and 10.0 μmol/L, respectively. (2) Cytokine synthesis: Treatment with 1.9 Joules/cm2 UVA and 150 μmol/L S-59 or AMT completely inhibited synthesis of the cytokine IL-8 by contaminating leukocytes during 5 days of platelet storage. After treatment with 75 μmol/L 8-MOP and 1.9 Joules/cm2 UVA, only low levels of IL-8 were detected. (3) Psoralen-DNA adduct formation: The combination of 1.9 Joules/cm2 UVA and 150 μmol/L S-59, AMT, or 8-MOP induced 12.0 ± 3.0, 6.0 ± 0.9, and 0.7 psoralen adducts per 1,000 bp DNA, respectively. (4) Replication competence: Polymerase chain reaction (PCR) amplification of small genomic DNA sequences (242-439 bp) after PCT was inhibited. The degree of PCR amplification inhibition correlated with the level of adduct formation (S-59 > AMT > 8-MOP). In contrast, 2,500 cGy gamma radiation, a dose that inactivates >5 log10 of T cells in blood products, had minimal effect on cytokine synthesis and did not induce sufficient DNA strand breaks to inhibit PCR amplification of the same small DNA sequences. These results demonstrate that leukocytes are sensitive to PCT with psoralens and among the psoralens tested S-59 is the most effective. Therefore, PCT has the potential to reduce the incidence of leukocyte-mediated adverse immune reactions associated with platelet transfusion.

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Grass, Joshua A., Derek J. Hei, Ken Metchette, et al. "Inactivation of Leukocytes in Platelet Concentrates by Photochemical Treatment With Psoralen Plus UVA." Blood 91, no. 6 (1998): 2180–88. http://dx.doi.org/10.1182/blood.v91.6.2180.2180_2180_2188.

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A photochemical treatment (PCT) process using a novel psoralen and long wavelength ultraviolet light (UVA, 320-400 nm) has been developed to inactivate bacteria and viruses in platelet concentrates. This study evaluated the efficacy of PCT for inactivation of leukocytes that contaminate platelet preparations. Three psoralens, 8-methoxypsoralen (8-MOP), 4′-aminomethyl 4,5′,8-trimethylpsoralen (AMT), and the novel psoralen S-59, were compared using the following four independent but complementary biological and molecular assays. (1) T-cell viability: Treatment with 150 μmol/L S-59 and 1.0 to 3.0 Joules/cm2 UVA inactivated >5.4 ± 0.3 log10 of T cells in full-sized single-donor plateletpheresis units. Using 1.0 Joule/cm2 UVA, the lowest dose of S-59, AMT and 8-MOP required to reduce the number of T cells to the limit of detection was 0.05 μmol/L, 1.0 μmol/L, and 10.0 μmol/L, respectively. (2) Cytokine synthesis: Treatment with 1.9 Joules/cm2 UVA and 150 μmol/L S-59 or AMT completely inhibited synthesis of the cytokine IL-8 by contaminating leukocytes during 5 days of platelet storage. After treatment with 75 μmol/L 8-MOP and 1.9 Joules/cm2 UVA, only low levels of IL-8 were detected. (3) Psoralen-DNA adduct formation: The combination of 1.9 Joules/cm2 UVA and 150 μmol/L S-59, AMT, or 8-MOP induced 12.0 ± 3.0, 6.0 ± 0.9, and 0.7 psoralen adducts per 1,000 bp DNA, respectively. (4) Replication competence: Polymerase chain reaction (PCR) amplification of small genomic DNA sequences (242-439 bp) after PCT was inhibited. The degree of PCR amplification inhibition correlated with the level of adduct formation (S-59 > AMT > 8-MOP). In contrast, 2,500 cGy gamma radiation, a dose that inactivates >5 log10 of T cells in blood products, had minimal effect on cytokine synthesis and did not induce sufficient DNA strand breaks to inhibit PCR amplification of the same small DNA sequences. These results demonstrate that leukocytes are sensitive to PCT with psoralens and among the psoralens tested S-59 is the most effective. Therefore, PCT has the potential to reduce the incidence of leukocyte-mediated adverse immune reactions associated with platelet transfusion.

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Yu, Yingli, Pengli Wang, Ruili Yu, Jiaxi Lu, Miaomiao Jiang, and Kun Zhou. "Long-Term Exposure of Psoralen and Isopsoralen Induced Hepatotoxicity and Serum Metabolites Profiles Changes in Female Rats." Metabolites 9, no. 11 (2019): 263. http://dx.doi.org/10.3390/metabo9110263.

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Pre-clinical safety evaluation of traditional medicines is imperative because of the universality of drug-induced adverse reactions. Psoralen and isopsoralen are the major active molecules and quality-control components of a traditional herbal medicine which is popularly used in Asia, Fructus Psoraleae. The purpose of this study is to assess the long-term effects of psoralen and isopsoralen with low levels on the biochemical parameters and metabolic profiles of rats. Three doses (14, 28, and 56 mg/kg) of psoralen and one dose (28 mg/kg) of isopsoralen were administered to rats over 12 weeks. Blood and selected tissue samples were collected and analyzed for hematology, serum biochemistry, and histopathology. Metabolic changes in serum samples were detected via proton nuclear magnetic resonance (1H-NMR) spectroscopy. We found that psoralen significantly changed the visceral coefficients, blood biochemical parameters, and histopathology, and isopsoralen extra influenced the hematological index. Moreover, psoralen induced remarkable elevations of forvaline, isoleucine, isobutyrate, alanine, acetone, pyruvate, glutamine, citrate, unsaturated lipids, choline, creatine, phenylalanine, and 4-hydroxybenzoate, and significant reductions of ethanol and dimethyl sulfone. Isopsoralen only induced a few remarkable changes of metabolites. These results suggest that chronic exposure to low-level of psoralen causes a disturbance in alanine metabolism, glutamate metabolism, urea cycle, glucose-alanine cycle, ammonia recycling, glycine, and serine metabolism pathways. Psoralen and isopsoralen showed different toxicity characteristics to the rats.

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Dissertations / Theses on the topic "Psoralène"

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Gaboriau, François. "Etude structurale des altérations photoinduites dans l'ADN par des dérivés monofonctionnels du psoralène." Paris 6, 1989. http://www.theses.fr/1989PA066731.

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Krieger, Célia. "Identification moléculaire et caractérisation fonctionnelle d'une nouvelle sous-famille de cytochromes P450, CYP71AZ, impliquée dans la synthèse de furanocoumarines et coumarines chez Pastinaca sativa." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0185/document.

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Les furanocoumarines (FCs) sont des métabolites secondaires principalement synthétisés chez quatre familles botaniques et dérivent de la voie de biosynthèse des phénylpropanoïdes. Ces phytoalexines interviennent dans les processus de défense de la plante et présentent un fort potentiel thérapeutique. Des travaux réalisés dans les années 1960 sur des cultures cellulaires en parallèle de l’utilisation de précurseurs radiomarqués ont permis de démontrer que de nombreuses enzymes impliquées dans cette voie appartenaient à la famille des cytochromes P450 (P450s). Seules deux d’entre elles avaient pu être identifiées d’un point de vue moléculaire au début de ce travail de thèse. Afin de générer des informations concernant le génome de plantes productrices de FCs, nous avons fait séquencer les ARNm extraits de feuilles de Pastinaca sativa, de Ruta graveolens et de Cullen cinereum. L’analyse in silico de ces trois banques de données a permis d’identifier près de 800 fragments d’ADNc codants pour des P450s. Des travaux antérieurs réalisés au laboratoire et l’analyse comparative des transcriptomes de ces 3 plantes nous ont amenés à nous focaliser sur la sous-famille CYP71AZ au travers d’une étude fine de CYP71AZ3 et CYP71AZ4. La caractérisation fonctionnelle de ces enzymes a été réalisée dans un système d’expression hétérologue eucaryote : Saccharomyces cerevisiae. Les résultats obtenus ont permis de montrer que CYP71AZ4 avait une spécificité de substrat assez large puisqu’elle pouvait métaboliser au moins une FC et 4 coumarines. L’analyse et la comparaison des constantes cinétiques pour chacun de ces substrats indiquent néanmoins que le psoralène est le substrat préférentiel. La caractérisation fonctionnelle de CYP71AZ3 a mis en évidence que cette enzyme pouvait hydroxyler l’esculétine, une coumarine, mais ne jouait aucun rôle dans la synthèse de FCs. Ces travaux mettent en évidence la diversité fonctionnelle au sein d’une même sous-famille enzymatique et permettent d’émettre des hypothèses nouvelles quant à l’apparition de cette voie de biosynthèse chez les Apiacées d’une part, et chez les autres familles botaniques d’autre part<br>Furanocoumarins (FCs) are secondary metabolites mainly synthetized in four botanical families deriving from the phenylpropanoid biosynthetic pathway. These phytoalexins are involved in plant defense mechanisms and present strong therapeutic potential. Early studies in the 1960s based on cell cultures and the use of radiolabeled precursors have shown that many enzymes involved in this pathway belong to the cytochrome P450 family (P450s). Only two of them had been identified from a molecular point of view at the beginning of this thesis. In order to generate information regarding the genome of plants producing FCs, we sequenced the mRNA extracted from leaves of Pastinaca sativa, Ruta graveolens, and Cullen cinereum. In silico analysis of these three libraries identified nearly 800 cDNA fragments encoding for P450s. Previous studies in the laboratory and comparative transcriptome analysis of these three plants have led us to focus on the subfamily CYP71AZ through a detailed study of CYP71AZ3 and CYP71AZ4. Functional characterization of these enzymes was performed in an eukaryote heterologous expression system: Saccharomyces cerevisiae. The results showed that CYP71AZ4 had a broad substrate specificity enough as it could metabolize one FC and 4 coumarins. The analysis and comparison of the kinetic constants for each of these substrates indicate, however, that the preferred substrate is psoralen. The functional characterization of CYP71AZ3 showed that this enzyme could hydroxylate esculetin, a coumarin, but played no role in the synthesis of FCs. This study highlights the functional diversity within a single enzyme subfamily and allows to issue new hypotheses about the emergence of this biosynthetic pathway in Apiaceae on one hand, and among other botanical families on the other hand

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Doerper, Sébastien. "Modification de la synthèse des furocoumarines chez Ruta graveolens L. par une approche de génie métabolique." Thesis, Vandoeuvre-les-Nancy, INPL, 2008. http://www.theses.fr/2008INPL070N/document.

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La rue officinale (Ruta graveolens L) est une plante connue comme étant particulièrement riche en métabolites secondaires et produisant notamment des molécules d’intérêt pharmaceutique comme les furocoumarines. Nous avons tenté par une approche de génie métabolique d’augmenter la teneur en furocoumarines produites dans les plantes. La mise en place de telles approches nous a également permis de mieux comprendre les mécanismes de régulation de la voie de biosynthèse des phénylpropanoïdes. Pour atteindre ces objectifs nous avons transformé la rue avec différents gènes placés sous le contrôle d’un promoteur constitutif fort, le promoteur 35S du CaMV. Pour chaque série de transformants nous avons étudié la teneur en furocoumarines et analysé les variations de composés phénylpropanoïdes (rutine, umbelliférone, ferulate, scopolétine). Parallèlement à cette analyse métabolique, une corrélation a été réalisée avec le niveau d’expression des transgènes et de certains endogènes par l’utilisation d’approche de PCR quantitative. Les séries de plantes transgéniques surexprimant les gènes codants pour la Coumaroyl ester 3’-Hydroxylase de rue (CYP98A22) et d’A. thaliana (CYP98A3) présentent toutes les deux une augmentation significative d’une facteur 3 de la teneur en furocoumarines. Par contre si les premières sont caractérisées par une diminution de la production en rutine et en umbelliférone, les secondes présentent une augmentation importante de la teneur en Scopolétine et en umbelliférone. Ces résultats suggèrent la coexistence de deux C3’H chez R. graveolens ayant des fonctions différentes, l’une d’entre elles étant impliquée directement ou non dans la synthèse de scopolétine. Si la transformation génétique de rues avec des gènes de la famille CYP98A induit des modifications du métabolisme secondaire, la surexpression d’un gène spécifique à la voie de biosynthèse des furocoumarines (gène cyp71AJ1, codant pour la psoralène synthase d’A. majus) permet d’augmenter uniquement la teneur en furocoumarines (X4). L’ensemble de ces travaux a permis de montrer l’intérêt d’une approche de génie métabolique pour générer des plantes présentant un intérêt potentiel pour la production de molécules d’intérêts pharmaceutiques<br>Garden Rue (Ruta graveolens L.) is a plant known as being particularly rich in secondary metabolites and in particular producing molecules of pharmaceutical interest like furocoumarines. By the use of a metabolic engineering approach, we tried to increase the content of furocoumarines produced in these plants but also to better understand the regulation mechanisms of the phenylpropanoïd biosynthesis pathway. To achieve these goals we transformed Ruta plants with various genes placed under the control of a strong constitutive promoter, CaMV 35S promoter. The plants we obtained were analyzed for their ability to overproduce furocoumarines but also other phenylpropanoïds like ferulate, umbelliferone, scopoletine or rutin. Using Real Time PCR experiments, a correlation was carried out with the level of expression of each transgene and several endogenous genes. Plants overexpressing either the Ruta or the Arabidopsis Coumaroyl ester 3 '-Hydroxylase (CYP98A22 and CYP98A3 respectively) display both a significant increase (3 time level) of the furocoumarin. However if the S-98A22 plants are characterized by a reduction in the production of rutin and umbelliferone, S-98A3 transgenic plants display a significant increase scopoletine and umbelliferone content. These results suggest the coexistence of two C3'H having different functions in Ruta. One of them might be involved more specifically in the synthesis of scopoletine. If the transformation of Ruta with genes belonging to the CYP98A family generates an enlarged of the secondary metabolism, we also showed that the overexpression of a gene belonging to the furocoumarins biosynthesis pathway (CYP71AJ1, the psoralen synthase) allowed a specific stimulation. Indeed a 4 time increase of the content of furocouramins was noticed in these transgenic plant lines. This work made it possible to make evidence of the interest of a metabolic engineering approach to generate plants of interest for the production of pharmaceutical molecules

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Guy, Julia. "Photochimiothérapie cutanée : Synthèse de deux molécules hybrides "psoralène-lactone" et études physico-chimiques et photochimiques de leurs interactions avec l'ADN." Université Louis Pasteur (Strasbourg) (1971-2008), 2005. http://www.theses.fr/2005STR13172.

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La photochimiothérapie est un terme générique qui désigne l'administration de médicaments photosensibilisants suivie d'une irradiation dans le spectre UV-visible. Les psoralènes font partie de cette classe de molécules photosensibilisantes et sont couramment utilisés en photomédecine, pour le traitement de nombreuses maladies d'hyperprolifération cutanée, en association avec une irradiation UVA. Cependant, l'apparition d'effets secondaires liés à la phototoxicité cutanée des molécules employées limite leur utilisation en thérapeutique. Afin d'accéder à de nouveaux dérivés de psoralène potentiellement utilisables en photochimiothérapie cutanée, nous avons synthétisé deux molécules hybrides basées sur le squelette noyau psoralène, bras espaceur, motif--méthylène--butyrolactone. Différentes études biologiques ont permis de mettre en évidence deux propriétés majeures de ces hétérodimères pour leur utilisation en photochimiothérapie cutanée : ils sont dépourvus de phototoxicité cutanée et ont présenté des activités antiprolifératives élevées sur trois lignées de cellules cancéreuses humaines et notamment sur celle du mélanome malin. Afin de caractériser la nature des interactions existant entre ces molécules et l'ADN, nous avons réalisé des expériences de physicochimie et de photochimie sur des complexes hétérodimères-ADN avant et après irradiation UV. Ces études semblent indiquer que dans leur état fondamental les dérivés "psoralène-lactone" s'intercalent dans l'ADN et provoquent une courbure du grand axe de celui-ci. Après irradiation UV, il semblerait que ces dérivés soient capables de ponter la double hélice en formant des cross-links<br>Photochemotherapy is the therapeutic use of radiation in combination with a photosensitizing chemical. Psoralens are well-known photosensitizing drugs which have been employed in photomedicine, in association with UVA radiation, to cure a number of hyperproliferative skin disorders. This therapeutic treatment is generally called PUVA, from psoralen plus UVA light. Nevertheless, the existence of some undesired phototoxic side effects limits the therapeutic use of psoralens. In recent years, many psoralen derivatives have been synthesized with the aim of weakening the phototoxicity on skin. Thus, we report the synthesis and the studies of DNA interactions of two psoralen-lactone heterodimers, which are unable to induce skin phototoxicity on mice and show significant antiproliferative activity on three human cancer cell lines. With the aim of understanding the behaviour of both hybrids toward DNA, we have realized physicochemical and photochemical experiments on heterodimers-DNA complexes. We have shown that, in the dark both hybrids are able to intercalate between DNA base pairs and seem to induce DNA bending. After UV radiation, both compounds exhibit a remarkable ability to give rise to cross-links with double stranded DNA

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Nguyen, Christophe. "Contribution à l'étude de la production de psoralène (furocoumarine) par la culture in vitro de plantes du genre psoralea (leguminosae)." Vandoeuvre-les-Nancy, INPL, 1992. http://www.theses.fr/1992INPL085N.

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Nous avons étudié la possibilité d'utiliser la culture in vitro de plantes du genre psoralea pour produire du psoralène une molécule photosensibilisante aux nombreuses applications industrielles. Nous avons tout d'abord envisagé la production de ces composés par la culture en milieu liquide de cellules de p. Cinerea. Nous avons constitue un souchier de 131 cals. La variabilité génétique induite par la mise en culture in vitro a été stabilisée pour la moitie d'entre eux. A partir de ces cals, nous avons également initié des cultures de cellules en milieu liquide les suspensions cellulaires. Nous avons mis en évidence que certains cals et suspensions cellulaires synthétisaient une molécule dont le spectre UV était très voisin de celui du psoralene. L'identité de ce compose demande à être confirmée. Nous avons également aborde la production de psoralène par des racines transformées par agrobacterium rhizogenes. Une souche a été inoculée à sept espèces de psoralées pour constituer un souchier de racines transformées. Cependant, nous n'avons jamais pu détecter de psoralène dans les racines transformées alors que des racines prélevées sur les plantes entières en contiennent

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Salahou, Adama. "Analyse radiocristallographique de molécules antitumorales (Ellipticinium) et photosensibilisantes (Psoralène) : étude de la cristallisation avec des fragments d'acides nucléiques." Bordeaux 1, 1987. http://www.theses.fr/1987BOR10515.

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Giuriato, Nathalie. "Toxicité génétique des psoralènes." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2P007.

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Huckel, Stahli Valérie. "Les psoralènes, interaction, mode d'action, effets secondaires et ressources naturelles." Nancy 1, 1996. http://www.theses.fr/1996NAN1A037.

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Seiller, Nathalie. "Les psoralènes : mécanisme d'action, intérêts et toxicitlé." Paris 5, 1994. http://www.theses.fr/1994PA05P138.

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Sai͏̈d, Abdou Elmadjid. "Contribution à l'étude de la relation structure-activité des psoralènes utilisés en thérapeutique." Besançon, 1996. http://www.theses.fr/1996BESA3502.

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Books on the topic "Psoralène"

1

Ugent, Steven Jay. Antisense oligonucleotides: Psoralen photoreactivity and enzymatic resistance. s.n.], 1991.

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Extracorporeal photochemotherapy: Clinical aspects and the molecular basis for efficacy. R.G. Landes, 1994.

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IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Some naturally occurring and synthetic food components, furocoumarins, and ultraviolet radiation. World Health Organization, International Agency for Research on Cancer, 1986.

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4

(Editor), Thomas B. Fitzpatrick, P. Forlot (Editor), M. A. Pasthak (Editor), and F. Urbach (Editor), eds. Psoralens. John Libbey & Co Ltd, 1989.

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Psoralen DNA Photobiology. Taylor & Francis Group, 2017.

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Psoralen DNA Photobiology. Taylor & Francis Group, 2017.

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P, Gasparro Francis, ed. Psoralen DNA photobiology. CRC Press, 1988.

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Gasparro, Francis P. Psoralen DNA Photobiology. Edited by Francis P. Gasparro. CRC Press, 2018. http://dx.doi.org/10.1201/9781351076128.

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Gasparro, Francis P. Psoralen DNA Photobiology. Edited by Francis P. Gasparro. CRC Press, 2018. http://dx.doi.org/10.1201/9781351076135.

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10

National Toxicology Program (U.S.) and National Cancer Institute (U.S.), eds. Photobiologic, toxicologic, and pharmacologic aspects of psoralens. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, 1986.

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Book chapters on the topic "Psoralène"

1

Bährle-Rapp, Marina. "Psoralene." In Springer Lexikon Kosmetik und Körperpflege. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_8630.

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Wagner, Hildebert, Rudolf Bauer, Dieter Melchart, and Anton Staudinger. "Fructus Psoraleae – Buguzhi." In Chromatographic Fingerprint Analysis of Herbal Medicines Volume IV. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32328-2_6.

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Dall’Acqua, F. "Psoralens: A Review." In Photosensitisation. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73151-8_38.

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Forlot, Paul E. "Pigmentogenic Effects of Psoralens." In Photosensitisation. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73151-8_33.

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McKenna, K. E. "PUVA, Psoralens and Skin Cancer." In Skin Cancer and UV Radiation. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60771-4_46.

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Marley, Karen A., Richard A. Larson, and Richard Davenport. "Alternative Mechanisms of Psoralen Phototoxicity." In ACS Symposium Series. American Chemical Society, 1995. http://dx.doi.org/10.1021/bk-1995-0616.ch015.

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Averbeck, Dietrich. "Mutagenesis Photoinduced by Psoralens in Yeast." In Light in Biology and Medicine. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5991-3_24.

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Moreno, Giuliana. "Cell Photosensitization by Psoralens and Porphyrins." In Primary Photo-Processes in Biology and Medicine. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-1224-6_19.

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Dall’Acqua, Francesco, Sergio Caffieri, Giovanni Rodighiero, et al. "Photoreactions of Furocoumarins (Psoralens and Angelicins)." In Primary Photo-Processes in Biology and Medicine. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-1224-6_15.

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Averbeck, D. "Mutagenesis by Psoralens on Eukaryotic Cells." In Photosensitisation. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73151-8_39.

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Conference papers on the topic "Psoralène"

1

Gasparro, Francis P. "Psoralen photobiology and photochemotherapy: perspectives and prospects." In SPIE Institutes for Advanced Optical Technologies 6, edited by Charles J. Gomer. SPIE, 1990. http://dx.doi.org/10.1117/12.2283677.

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2

Jacques, Steven L., Lisa A. Buckley, Scott A. Prahl, and Kenton W. Gregory. "Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis." In OE/LASE '94, edited by George S. Abela. SPIE, 1994. http://dx.doi.org/10.1117/12.179911.

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Bryantseva, Natalya G. "Photophysical and spectral properties of new psoralen photosensitizers." In SPIE Proceedings, edited by Valery V. Tuchin. SPIE, 2006. http://dx.doi.org/10.1117/12.697353.

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Bryantseva, N. G., and I. V. Sokolova. "Theoretical investigation of absorption spectra from excited states of psoralens." In SPIE Proceedings, edited by Gelii A. Zherebtsov and Gennadii G. Matvienko. SPIE, 2006. http://dx.doi.org/10.1117/12.675192.

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Lysenko, Eugene P., Alla A. Kyagova, and Alexander Y. Potapenko. "Mechanism of photobiological effects of psoralens: the involvement of photo-oxidized psoralens as reactive intermediate species in induction of photosensitized hemolysis and skin erythema." In Saratov Fall Meeting 2001, edited by Valery V. Tuchin. SPIE, 2002. http://dx.doi.org/10.1117/12.475620.

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6

Rocha, M. S., and O. N. Mesquita. "Variation of entropic elasticity of DNA-Psoralen complex under UV light." In Optics & Photonics 2005, edited by Kishan Dholakia and Gabriel C. Spalding. SPIE, 2005. http://dx.doi.org/10.1117/12.619128.

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Kyagova, Alla A., Mekhriban I. Ismailova, Mikhail V. Malakhov, and Alexander Y. Potapenko. "Hemolysis induced by psoralen previously photo-oxidized in ethanol or aqueous solutions." In SPIE Proceedings, edited by Valery V. Tuchin. SPIE, 2004. http://dx.doi.org/10.1117/12.578949.

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Buckley, Lisa A., Kenton W. Gregory, Deborah T. Bahlman, et al. "Photochemotherapy of intimal hyperplasia using psoralen activated by uv light in porcine model." In Photonics West '96, edited by R. Rox Anderson. SPIE, 1996. http://dx.doi.org/10.1117/12.239996.

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Thomaz, Douglas, Vinicius Silva, Pierre Santos, Matheus Oliveira, and Edson Rodrigues. "Physicochemical investigation of Psoralen binding to double stranded DNA through electroanalytical and cheminformatic approaches." In 5th International Electronic Conference on Medicinal Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecmc2019-06298.

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Perree, Jop, Ton G. J. M. van Leeuwen, Evelyn Velema, and Cornelius Borst. "Low-dose psoralen and UVA (PUVA) therapy-enhanced arterial shrinkage after balloon angioplasty in rabbits." In BiOS '98 International Biomedical Optics Symposium, edited by R. Rox Anderson, Kenneth E. Bartels, Lawrence S. Bass, et al. SPIE, 1998. http://dx.doi.org/10.1117/12.312321.

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Reports on the topic "Psoralène"

1

Shi, Yun-bo. Photochemistry of psoralen-DNA adducts, biological effects of psoralen-DNA adducts, applications of psoralen-DNA photochemistry. Office of Scientific and Technical Information (OSTI), 1988. http://dx.doi.org/10.2172/5069947.

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Spielmann, Peter Hans. The application of psoralens to the study of DNA structure, function and dynamics. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/10115059.

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Mateeva, Valeria, Doncho Etugov, and Grisha Mateev. Efficacy of Systemic PUVA (Psoralen Plus Ultraviolet Light-A) in Bulgarian Patients with Mycosis Fungoides. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, 2018. http://dx.doi.org/10.7546/crabs.2018.11.15.

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4

Perera, Anthonige. Genes Affecting the Repair and Survival of Escherichia coli Following Psoralen-Induced Damage: a DNA Interstrand Crosslinking Agent. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.2192.

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5

Cheng, S. Repair of psoralen crosslinks in Escherichia coli: In vitro studies with the RecA protein and (A)BC excinuclease. Office of Scientific and Technical Information (OSTI), 1990. http://dx.doi.org/10.2172/7192240.

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Livingstone, Dena. The Role of Translesion DNA Polymerase(s) in the Survival of Escherichia Coli Exposed to UVA Light in the Presence of Psoralen and Angelicin. Portland State University Library, 2015. http://dx.doi.org/10.15760/honors.199.

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