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Dissertations / Theses on the topic 'Pyrazolo[3'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Bratenko, M. K. "Modern organic synthesis of pyrazolo[3,4-e][1,2,3]triazolo[1,5-a]diazepine-3-carboxamides." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18354.

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2

Do, Khoa Quang. "Design, Synthesis and Binding Studies of Trisubstitutedpyrazolo[3,4-d]pyrimidines." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/367533.

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Pyrazolo[3,4-d]pyrimidines were known as adenosine antagonists at the rat A1 and A2A adenosine receptors based on our previous studies. In this study, 245 pyrazolo[3,4-d]pyrimidines derivatives with various benzyl substitutents at N-1 and various hydrophobic side chains at C-4 and C-6 were synthesized and screened at the human A1, A2A and A3 adenosine receptors. 14 out of 245 compounds were resynthesized and purified to determine the Ki values of these compounds at the human A1 adenosine receptor. Chapter 1 of the thesis is a literature review of adenosine research. It describes the physiology

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3

Laube, Markus. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-160091.

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Eine erhöhte COX-2-Expression wird bei Krankheiten wie rheumatoider Arthritis aber auch Parkinson, Alzheimer und Krebs beobachtet. Die nichtinvasive Visualisierung und Quantifizierung der COX 2-Expression in vivo mittels Positronen-Emissions-Tomographie (PET) könnte wertvolle Beiträge zur Diagnose dieser Krankheiten liefern. Zur Nutzung der PET-Technik werden geeignete COX-2-adressierende Radiotracer benötigt, deren Entwicklung auch die Identifizierung neuer, der Radiomarkierung zugänglicher COX-2-Inhibitoren als Leitstrukturen voraussetzt. Ziel dieser Arbeit war die Synthese von selektiven,

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4

Motson, Graham Robert. "Coordination chemistry of 3-(2'-pyridyl) pyrazole derivative ligands." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391153.

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5

Desalegn, Nebiyou. "Kinetic Studies Of The Thermolysis Of 3-Halogenated-4,5-Dihydro-3h-Pyrazoles." Digital Archive @ GSU, 2005. http://digitalarchive.gsu.edu/chemistry_theses/1.

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3-Chloro-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3b) and 3-bromo-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3c) were prepared for the thermolysis project. The thermal decompositions of 3b and 3c were monitored using 1H NMR spectroscopy. Plots of ln (% starting material) vs. time (sec) were linear for at least two half lives and the first order rate constants were determined over at least a 30o temperature range. The relative reactivity was found to be 3c > 3b. The activation parameters determined for the thermal decomposition of the pyrazoline at 150oC were found to be

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6

Davies, Emyr D. "Novel bis (pyrazol-3-yl) ligands : their synthesis and coordination chemistry." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54683/.

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This thesis describes studies into the development of new bis(pyrazol-3-yl) ligands including our studies into their coordination chemistry. Chapter 1 is a brief introduction to chelating ligands based on heterocycles and outlines specifically looks at poly(pyrazole-l-yl) ligands as well as the few bis(pyrazole-3-yl) ligands publishes to date. Chapter 2 looks at the traditional synthetic routes to bis(pyrazol-3-yl) ligands and describes how we have manipulated these techniques to synthesise some novel ligands of our own. Chapter 3 includes a study of the transition metal coordination chemistry

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7

Panasenko, N. V., and М. K. Bratenko. "Synthesis of 3-(3-aryl-1-phenyl-1H-4-pyrazolil)-chromen-2-ones." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/16864.

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8

Barus, M. M. "А new approach to the preparation of 4-difluoromethyl-1Н-pyrazole-3-carboxylic acids". Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19532.

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9

Oleksik, Laurence. "Methodology for the synthesis of 4 or 5-substituted-3-perfluoroalkyl pyrazoles." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/30087.

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Initially the perfluoroacylation of a range of commercially available vinyl ethers and conversion of the resulting perfluoroacylated enol ethers to 1-H-pyrazoles via reaction with hydrazine is reported. The selective synthesis of a range of alpha-aryl vinyl ethers using Heck chemistry is then reported. Subsequent perfluoroacylations of the vinyl ethers followed by reaction of the resulting perfluoroacyl enol ethers with hydrazine affords a range of 5-aryl-3-perfluoroalkyl pyrazoles in good yields.;Alternative methodology for the synthesis of 5-aryl-3-perfluoroalkyl pyrazoles is then described

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10

Nadir, Saïd. "Complexes de l'acide 3, 5-pyrazole dicarboxylique : synthèses, études structurales, utilisation pour la préparation de céramiques conductrices." Lille 1, 1996. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/1996/50376-1996-182.pdf.

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La synthese de ceramiques oxydes conductrices, par reaction a l'etat solide, necessite des traitements a haute temperature. Une autre methode est d'utiliser des composes de coordination precurseurs pour la preparation de materiaux oxydes hautement disperses. Nous avons utilise l'acide 3,5-pyrazole dicarboxylique (dcph#3) qui se decompose a 300c ; ce diacide est potentiellement tetrachelatant. Nous avons obtenu des complexes stables avec une grande variete d'elements (cu, bi, vo, ba, pb, ni, co) ; ceux ci ont ete caracterises par a. T. G et par diffraction x a haute temperature. La structure cr

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11

Bacher, W. [Verfasser]. "Zur Reaktion von 4-Acylsubstituiertem 1-Phenyl-3-methyl-pyrazolon-5 mit Actinidenionen in waessriger Loesung / W. Bacher." Karlsruhe : KIT-Bibliothek, 2009. http://d-nb.info/118690495X/34.

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12

Cottineau, Bertrand. "Contribution à l'étude du 3-hydroxy-1H-pyrazole-4-carboxylate d'éthyle : application à la synthèse de composés antidiabétiques." Orléans, 2002. http://www.theses.fr/2002ORLE2014.

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Le diabète est l'affection endocrinienne de loin la plus fréquente. Il touche environ deux millions de personnes en France et se caractérise par une élévation de la concentration plasmatique en glucose et triglycérides. Cette hyperglycémie chronique contribue à l'apparition de complications spécifiques. Dans le cadre d'une recherche de nouveaux agents antidiabétiques, nous avons préparé à partir d'un synthon commun, le 3-hydroxy-1H-pyrazole-4-carboxylate d'éthyle, des composés diversement fonctionnalisés notamment en position 1 et 3 via des réactions de O et N-alkylations régiospécifiques, et

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13

Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyr

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14

Rosales, Pauline Fagundes. "Bi-heterociclos a partir do Ácido Levulínico: Síntese de 5-[(5-(trifluormetil)-5-hidroxi-(3-substituido)-4,5-diidro-1H-pirazol-1-il)-1-propan-1-ona-3-il]-2-metil-7-trifluormetil)pirazolo[1,5-a]pirimidinas." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/10535.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>An efficient method to obtain 2-methyl-5-(methylpropanoate-3-yl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine 2 from the reaction of compound methyl 7,7,7-trifluoro-4-methoxy-6-oxo-heptenoate with 3-amino-5-methyl-1H-pyrazol. This compound 2 brought to reaction with hydrazine monohydrate to obtain 2-methyl-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-5-propanehydrazine 3 and after were later brought to cyclocondensation reaction with a series of β-alkoxyvinyltrifluoromethyl ketones giving the series of news bi-heterocyclic 5-[(5-(trifl

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15

HEMONIC, DANIELE. "Etude cinetique et thermodynamique de l'extraction du cuivre par la 1-phenyl-3-methyl-4-stearoyl-pyrazol-5-one : comparaison a d'autres extractants." Paris, ENMP, 1987. http://www.theses.fr/1987ENMP0156.

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Etude de l'extraction du cuivre en milieu sulfate par une pyrazolone diluee dans le solvesso 150. Determination des constantes d'equilibre et de cinetique d'extraction, utilisation d'un modele thermodynamique

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16

Hemonic, Danielle. "Etude cinétique et thermodynamique de l'extraction du cuivre par la 1-phényl-3-méthyl-4-stéaroyl-pyrazol-5-one comparaison à d'autres extractants /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376059420.

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17

Delaunay, Thierry. "Synthèses concises de pyrazoles et pyridones diversement fonctionnalisées dans le but d'effectuer des réactions de couplages croisés sélectifs." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00878928.

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Ce mémoire est subdivise en deux parties. La première partie concerne la synthèse de pyrazoles présentant un intérêt sur le plan agrochimique. En effet, le noyau pyrazole est présent dans de nombreux composes ayant des activités biologiques diverses et en particulier antifongique. Au cours de ce travail, nous avons développé diverses approches convergentes de pyrazoles diversement substitués au moyen de réactions de couplages croisés pallado-catalyses sélectifs et séquentiels à partir de pyrazoles possédant différents points d'encrages. Dans la deuxième partie, nous nous sommes intéressés à la

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18

CHAOUI, ROQUAI M'HAMMED. "Extraction d'indium (iii) en milieu chlorure par le 3-phenyl-4-benzoyl-5-hydroxy-isoxazole. Synergies. Comparaisons avec les 4-acyl-5-hydroxy-pyrazoles." Université Louis Pasteur (Strasbourg) (1971-2008), 1995. http://www.theses.fr/1995STR13134.

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Ce travail traite de l'extraction d'indium (iii) a partir du milieu chlorure par le 3-phenyl-4-benzoyl-5-hydroxy-isoxazole (hpbi) associe a des agents de synergie tels l'oxyde de tri-n-octylphosphine (topo) ou le chlorure de tri-n-octylammonium (tomacl). Une interaction forte entre hpbi et topo a ete mise en evidence par differentes techniques spectroscopiques (rmn du #1h, #1#3c, #3#1p, ir et uv). Les formes tautomeres de hpbi dans les divers solvants d'extraction ont ete determinees. Dans les extractions synergiques, des especes mixtes ont ete mises en evidence: incl#x(pbi)#3#-#x(topo)#2 (x =

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19

Holz, Karsten. "Enol-Konjugate von 1-Phenyl-3-methyl-4-amino-3-pyrazolin-5-on als "minor metabolites" im Stoffwechsel von Metamizo. (Novalgin R) : Untersuchungen zur Analytik, zu Nachweis, Bildung und Verbleib metastabiler Phase-II-Metaboliten bei der Ratte /." [S.l. : s.n.], 1997. http://www.gbv.de/dms/bs/toc/226144828.pdf.

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20

Piovesan, Luciana Almeida. "Síntese de novos heterociclos a partir do ácido levulínico." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/4233.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The synthesis of new compounds alkyl 3-azolyl propanoate e alkyl 3-azolyl propanoic acid structurally analogues to gamma-aminobutiric acid (GABA) is reported. One more time using the acetal acylation method, now the acetal derivative of 4-oxopentanoic acid (levulinic acid), the methyl 4,4- dimethoxypentanoate, were obtained the precursors methyl 7,7,7-trifluoro[chloro]-4- methoxy-6-oxo-heptenoates, 1,3-dieletrophilic precursor with alcanoate substituent. Are presented efficient and regioespecific synthetic routes from reactions o

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21

Ciccolini, Cecilia. "Synthesis of Mono and Poly-Heterocycles starting from 1,2-Diaza-1,3-Dienes (or precursors) as Building Blocks." Doctoral thesis, Urbino, 2020. http://hdl.handle.net/11576/2674162.

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22

Marouani-Keraghel, Saïda. "Reduction electrochimique de composes d'uranyle en milieu organique." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13175.

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Etude de la reduction chimique de sels (nitrate et acetate) d'uranyle et des complexes (phenyl-1 methyl-3 acyl-4 pyrazolones-5) et beta-cetophosphonates d'uranyle en milieu organique et en presence de perchlorate d'ammonium sur une electrode de mercure

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23

Kumari, Archana. "Synthesis of Pyrazolo [3, 4-b] pyridine by Knovengel Condensation." Thesis, 2009. http://ethesis.nitrkl.ac.in/190/1/.

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We have successfully prepared some novel pyrazole derivatives. More interestingly, a new pyrazolopyridine derivative i.e. Ethyl 6-amino-1,3-diphenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate was prepared by the knovengel condensation of 5-amino-pyrazole-4-carbaldehyde and ethylcyanoacetate.

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24

洪讚誠. "Synthesis and thermal reaction of dimethyl-3, 3-cyclopentyl-3H-pyrazole-4, 5-dicarboxylate." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/46555386938756761561.

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碩士<br>靜宜大學<br>應用化學研究所<br>86<br>Thermolysis of dimethy1-3,3-cyclopentyl-3H-pyrazole-4,5-dicarboxylate(20) afforded dimethy1-4,5,6,7-tetrahydroindazole-2,5-dicarboxylate(24) and dimethy1-1,5-tetramethylene-pyrazole-3,4-dicarboxylate(25) in 69% and 8%, respectively. The mechanism of this reaction is suggested to undergo two competitive pathways. (1)After heating the compound 20 can undergo ring expansion(1,5-sigmatropic migration), i.e. the cyclopentyl group can ring-expand form C3 to N2 to form the compound. 25. (2) Alternatively, the cyclopentyl group of the compound 20 can undergo ring expansi

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25

Chih-Wen, Su, and 蘇志文. "Synthesis of 5-Methyl-2-substituted-2H-pyrazol-3-yl-amine Derivatives." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/67023478991124518308.

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碩士<br>國立臺灣科技大學<br>纖維及高分子工程系<br>89<br>In this study, the reaction of acetoacetamide with hydrazine hydrate and phenyl hydrazine was shown to give compounds 3a and 3b. First, the reaction of compounds 7a~7b and 11a~11b with a solution of compounds 3a and 3b in water by nitrosation at position 4 in low temperature, and were coupled with aromatic benzylamine derivatives. Second, the reaction of compound 3a with ethyl acetoacetate, acetoacetamide, phthalic anhydride and nitric acid was shown to give compounds 17, 23, 27 and 30. Third, a solution of compound 3b in ethanol was condensed with aromatic

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26

詹淑秦. "Investigation of synthesis and anti-allergic activityof 2-ethyl-3, 4-dimethylfuro [ 2, 3-c ] pyrazoles." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/61087201187943624709.

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27

Lin, Kuan-Ting, and 林冠廷. "Mesogenic Heterocycles Formed by Quinoxalines, Bis–pyrazoles, and Bis–1, 3, 4–Oxadiazoles." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/u7b64v.

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碩士<br>國立中央大學<br>化學學系<br>103<br>This thesis is devided into four different series. In series 1, two new structures of unsymmetric 1, 3, 4–oxa(thia)–diazoles 1a–b and 2 containing both quinoxaline and naphthalene moieties were prepared and their mesomorphic properties were investigated. The mesomorphic behavior of compounds 1–2 was studied by DSC analysis and polarized optical microscopy. All compounds 1a and 2 exhibited hexagonal columnar phases (Colh), which were also confirmed by powder XRD diffractometer. Ncell and Rar values equal to 5.23 and 22.73 Å within a slice of 9.0 Å thick were also

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28

Chang, Wei Chou, and 張為舟. "Synthesis and Properties of Bisheterocyclic Mono and Disazo Dyes based on 5-Amino-3-Methyl- Pyrazole Compound." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/28114396055994828055.

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碩士<br>國立臺灣科技大學<br>高分子工程系<br>94<br>In this study,5-amino-3-methyl-4-(6’-substituted-bezothiazol-ylazo)-pyrazole compounds have been synthesized by the cyclocondensation reaction of 2-(2’-hydrozone-3’-ketimino- butyro-nitrile)-6-substituted-benzothiazole with hydrazine hydrate.The dyes were dehydrated with 4-substituted-benzal -dehyde to give 5-(4’-substituted-benzylideneamino)-4-(6’-sub-stituted benzothiazolylazo)-3-methyl-pyrazole,and obtained 5-(4’-substituted-phenylazo)-4-(6’-substituted-benzothiazolylazo)-3-methyl-pyrazole by coupled with 4-substituted-benzene. The structures of these compo

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29

Li, Kun-Yu, and 李坤育. "Synthesis and Reactivity Study of the Tris[3-2-pyridyl)pyrazolyl]hydroborate Iron Complexes." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/4ywxbq.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學系碩士班<br>103<br>Trispyrazolylborate (Tp&;#8722;) type compound is a very important ligand set for small molecules activation the metalloenzyme mimicking system. Tris[3-(2-pyridyl)pyrazolyl]-hydroborate (Tp(py)&;#8722;) is a new type of Tp- ligand set which provides additional pyridine coordination site in 3-postion to explore some new coordination behavior for metal complexes. It is worth mentioning that there are no example of iron complexes containing Tp(py)&;#8722; ligand. Therefore, we focus on the synthesis and reactivity study of Tp(py)FeCl compound for the outer py

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30

Lei-Yea and 王麗雅. "Synthesis and antipletelet activities of 1-substituted 5-methyl-3-phenylfuro[3,2-c]pyrazoles." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/21141569518536257109.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>81<br>A series of 1-substituted 5-methyl-3-phenylfuro[3,2-c] pyrazoles(III1-11) and its intermediates (II1-13) have been synthesized,and evaluated for antipletelet activities.Most of them showed significant effect on the inhibition of platelet aggregation that induced by collagen and arachidonic acid. Among them 5-methyl-2-furyl phenyl ketone 3',4'-dichlorophenyl hydrazone (II6) was the most promising and therefore the action mechanism of this compound was furth

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31

Holland, Lars [Verfasser]. "Synthese und Untersuchung von Platinkomplexen der Liganden 1-Methyluracil, 2,2'-Bipyridin, 2-3'-Pyrazolyl)pyridin und Bis(2-pyridylcarbonyl)amid / Lars Holland." 2008. http://d-nb.info/997480351/34.

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32

Asad, Ali [Verfasser]. "Synthesis of sterically encumbered biaryls by [3+3] cyclocondensation reactions and synthesis of arylated pyrazoles, bis(diaryl)sulfones, and bis(alkenyl)pyridines by Pd(0)-catalysed cross-coupling reactions / vorgelegt von Ali Asad." 2010. http://d-nb.info/1010726609/34.

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33

Prokofieva, Angelina. "Bioinspired oxidation reactions of phenols with dinuclear copper complexes." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-000D-F12D-0.

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34

Busch, F., A. Mobasheri, P. Shayan, C. Lueders, R. Stahlmann, and M. Shakibaei. "Resveratrol modulates interleukin-1beta-induced phosphatidylinositol 3-kinase and nuclear factor kappaB signaling pathways in human tenocytes." 2012. http://hdl.handle.net/10454/5903.

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Resveratrol, an activator of histone deacetylase Sirt-1, has been proposed to have beneficial health effects due to its antioxidant and anti-inflammatory properties. However, the mechanisms underlying the anti-inflammatory effects of resveratrol and the intracellular signaling pathways involved are poorly understood. An in vitro model of human tenocytes was used to examine the mechanism of resveratrol action on IL-1beta-mediated inflammatory signaling. Resveratrol suppressed IL-1beta-induced activation of NF-kappaB and PI3K in a dose- and time-dependent manner. Treatment with resveratrol enhan

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