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Relevant bibliographies by topics / Pyrazolone derivatives

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Academic literature on the topic 'Pyrazolone derivatives'

Author: Grafiati

Published: 18 May 2024

Last updated: 25 July 2025

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Journal articles on the topic "Pyrazolone derivatives"

1

Abd-Ella, Aly A., Saoud A. Metwally, Mokhtar A. Abd ul-Malik, et al. "A review on recent advances for the synthesis of bioactive pyrazolinone and pyrazolidinedione derivatives." Current Chemistry Letters 11, no. 2 (2022): 157–72. http://dx.doi.org/10.5267/j.ccl.2022.2.004.

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Oxo derivatives of pyrazolines and pyrazolidines are important heterocyclic compounds due to their unique biological activities and have been widely applied in pharmaceutical and agromedical fields. In this review, we provide an account of some recent advances in the field of pyrazolone chemistry, specifically on the reported synthesis methods of pyrazolinone (3-oxo-1,2-dihydropyrazole) and 3,5-pyrzolidinediones (3,5-dioxotetrahydropyrazoles) derivatives.

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Edrees, Mastoura M. "Synthesis of 4-hydrazinopyrazolo[3,4-d]pyrimidines and their Reactions with Carbonyl Compounds." Journal of Chemical Research 37, no. 1 (2013): 6–10. http://dx.doi.org/10.3184/174751912x13543818811749.

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Synthesis of a new 4-hydrazinopyrazolo[3,4- d]pyrimidine was achieved via heating (4,6-dithioxo-1 H-pyrazolo[3,4- d] pyrimidin-3-yl)acetonitrile with hydrazine hydrate. Reactions of the latter product with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues afforded the corresponding hydrazone and pyrazole derivatives, respectively. Similarly, condensation of 2-[6-(benzylsulfanyl)-4-hydrazino-1 H-pyrazolo[3,4- d]pyrimidin-3-yl]acetonitrile with thiophene-2-carbaldehyde and ethyl hydrazonoacetoacetate analogues gave the respective hydrazone and pyrazolone derivatives. Alkylation

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Gil-Ordóñez, Marta, Camille Aubry, Cristopher Niño, Alicia Maestro, and José M. Andrés. "Squaramide-Catalyzed Asymmetric Mannich Reaction between 1,3-Dicarbonyl Compounds and Pyrazolinone Ketimines: A Pathway to Enantioenriched 4-Pyrazolyl- and 4-Isoxazolyl-4-aminopyrazolone Derivatives." Molecules 27, no. 20 (2022): 6983. http://dx.doi.org/10.3390/molecules27206983.

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A series of N-Boc ketimines derived from pyrazolin-5-ones have been used as electrophiles in enantioselective Mannich reactions with different 1,3-dicarbonyl compounds. This method provides a direct pathway to access the 4-amino-5-pyrazolone derivatives bearing a quaternary substituted stereocenter and containing two privileged structure motifs, the β-diketone and pyrazolinone substructures. The adducts were obtained in excellent yields (up to 90%) and enantioselectivities (up to 94:6 er) by employing a very low loading of 2 mol% of a quinine-derived bifunctional squaramide as an organocatalys

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4

Pattan, S. R., P. A. Chavan, R. A. Muluk, et al. "SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME HETEROCYCLES CONTAINING OXADIAZOLE AND PYRAZOLE RING FOR ANTI-BACTERIAL, ANTI-FUNGAL AND ANTI-TUBERCULAR ACTIVITIES." INDIAN DRUGS 49, no. 03 (2012): 18–24. http://dx.doi.org/10.53879/id.49.03.p0018.

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1, 3, 4-oxadiazoles were synthesized by treating pyrazine-2-carbohydrazide with CS2 and alc. KOH and their derivatives were prepared by using R-Cl compounds. pyrazolones were synthesized by treatingpyrazine-2-carbohydrazide with ethyl acetoacetate. The derivatives of pyrazolone were prepared by refluxing pyrazolone with formaldehyde and different substituted secondary amines. All the synthesized compounds were characterized by IR, 1H-NMR and elemental analysis and evaluated for antibacterial, antifungal and antitubercular activities.

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Gediz Erturk, Aliye, and Hilal Omerustaoglu. "Synthesis and Cytotoxic Evaluation of Some Substituted 5-Pyrazolones and Their Urea Derivatives." Molecules 25, no. 4 (2020): 900. http://dx.doi.org/10.3390/molecules25040900.

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In this paper, a series of new substituted-5-pyrazolones were first synthesized, then formulated by the Vilsmeier–Haack reaction to obtain substituted-4-carbaldehyde-5-pyrazolones. In the final step, when urea was reacted with formulated pyrazolones, we found that, instead of the C=N bond in azomethine form, the compounds tautomerized to form a series of novel pyrazole-4-ylidenemethylurea structures. The structures of these compounds were elucidated by FTIR, 1H, 13C NMR, LC-MS/MS, and elemental analysis methods. The cytotoxic and antioxidant effects of substituted 5-pyrazolones and their pyraz

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Yang, Kai, Xiaoze Bao, Ye Yao, Jingping Qu, and Baomin Wang. "Iodine-mediated cross-dehydrogenative coupling of pyrazolones and alkenes." Organic & Biomolecular Chemistry 16, no. 34 (2018): 6275–83. http://dx.doi.org/10.1039/c8ob01645c.

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Manojkumar, Parameswaran, Thengungal Ravi, and Gopalakrishnan Subbuchettiar. "Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells." Acta Pharmaceutica 59, no. 2 (2009): 159–70. http://dx.doi.org/10.2478/v10007-009-0018-7.

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Synthesis of coumarin heterocyclic derivatives with antioxidant activity andin vitrocytotoxic activity against tumour cellsThe aim of the present work was to synthesise coumarinyl heterocycles and to elucidate the potential role of these compounds as antioxidants and cytotoxic agents against Dalton's lymphoma ascites tumour cells (DLA) and Ehrlich ascites carcinoma cells (EAC). The synthesis of coumarin derivatives containing pyrazole, pyrazolone, thiazolidin-4-one, 5-carboxymethyl-4-thiazolidinone and 3-acetyl-1,3,4-oxadiazole ring is reported. 4-Methylcoumarinyl-7-oxyacetic acid hydrazide (1

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Zhang, Wande, Shah Nawaz, Yue Huang, et al. "C-4 benzofuranylation of pyrazolones by a metal-free catalyzed indirect heteroarylation strategy." Organic & Biomolecular Chemistry 19, no. 46 (2021): 10215–22. http://dx.doi.org/10.1039/d1ob01920a.

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A metal-free catalyzed indirect heteroarylation of pyrazolones with 2-(3-hydroxy-3,3-diarylprop-1-yn-1-yl)phenols has been developed, delivering a wide range of novel 4-benzofuran-substituted pyrazolone derivatives.

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Brogden, Rex N. "Pyrazolone Derivatives." Drugs 32, Supplement 4 (1986): 60–70. http://dx.doi.org/10.2165/00003495-198600324-00006.

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Bao, Xiaoze, Xingyue Wang, Jin-Miao Tian, Xinyi Ye, Baomin Wang, and Hong Wang. "Recent advances in the applications of pyrazolone derivatives in enantioselective synthesis." Organic & Biomolecular Chemistry 20, no. 12 (2022): 2370–86. http://dx.doi.org/10.1039/d1ob02426d.

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Dissertations / Theses on the topic "Pyrazolone derivatives"

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Mariappan, G. "Cardioprotective properties of pyrazotone derivatives in myocardial ischemic reperfusion injury." Thesis, University of North Bengal, 2011. http://hdl.handle.net/123456789/1501.

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Vetica, Fabrizio [Verfasser]. "Organocatalytic Asymmetric Synthesis of Isochromanones, Tetranortriterpenoids and Pyrazolone Derivatives / Fabrizio Vetica." München : Verlag Dr. Hut, 2018. http://d-nb.info/1155056213/34.

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Motson, Graham Robert. "Coordination chemistry of 3-(2'-pyridyl) pyrazole derivative ligands." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391153.

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Nakhai, Azadeh. "Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives." Stockholm, 2009. http://diss.kib.ki.se/2009/978-91-7409-687-3/.

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Yazici, Ceyda. "Synthesis Of 4-iodopyrazole Derivatives." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609750/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The electrophilic cyclization of the acetylenic hydrazones initiated by molecular iodine could provide new ways of synthesizing biologically active 4-iodopyrazole derivatives, which are important precursors for the synthesis of highly substituted pyrazole derivatives. For this reason, we investigated the synthesis of 4-iodopyrazole derivatives, such as 1-aryl- 5-alkyl/aryl-4-iodopyrazoles, star

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Rango, Enrico. "PRECLINICAL CHARACTERIZATION OF SFK INHIBITORS, PYRAZOLO[3,4-d]PYRIMIDINE SCAFFOLD-BASED DERIVATIVES, FOR CANCER TREATMENT." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1140389.

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The first part of this thesis essentially focuses on the preclinical characterization of Si306, a pyrazolo[3,4-d]pyrimidine derivative, identified as a very promising anticancer agent. This compound has shown a favorable in vitro and in vivo activity profile against neuroblastoma (NB) and glioblastoma (GBM) models by acting as a competitive inhibitor of c-Src tyrosine kinase. Nevertheless, the good antitumor activity of Si306 is associated with sub-optimal aqueous solubility, which might hinder its further development. In this context, drug delivery systems were developed to overcome the poor

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GRECO, CHIARA. "Synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine derivatives active as SGK1, Fyn and Src kinases inhibitors." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1001600.

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The pathogenesis of many cancers is characterized by mutations, overexpression and dysregulation of protein kinases. As a result, increasing attention has been directed towards the identification of novel kinase inhibitors for cancer therapy. The work performed here focuses on the synthesis of a series of pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of the serine-threonine kinase SGK1, and the tyrosine kinases Fyn and Src. The first set of compounds are analogues of the in house SGK1 inhibitor SI113 which had previously demonstrated anti-cancer activity. In fact SI113 resulted to b

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Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyr

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Pasin, Juliana Saibt Martins. "Atividade antipirética e antiinflamatória de derivados 5-trifluormetil-4,5-diidro-1H-1-carboxiamida pirazol em ratos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/28004.

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A febre é um aumento regulado da temperatura corporal central, caracterizada por uma alteração no centro termorregulatório, a qual resulta da interação entre o sistema nervoso central e o imunológico. Enquanto a febre caracteriza lesão celular, infecção e inflamação, ela tem sido considerada o mais importante componente da resposta de fase aguda. Embora existam evidências de que a febre aumenta a defesa do hospedeiro, alguns estudos têm sugerido que o aumento da temperatura central a níveis febris pode ser prejudicial. Portanto, nas situações clínicas nas quais os riscos associados com a febre

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Crotti, Simone. "Computer assisted synthesis and in-vitro cytotoxic evaluation of new pyrazole-fused isoquinolinoquinones derivatives as PI3K receptor antagonist with promising antitumoral activity." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11206/.

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The importance of pyrazole and isoquinoline-5,8-dione scaffolds in medical chemistry is underlined by the high number of drugs currently on trading that contains these active ingredients. Due to their cytotoxic capability, the interest of medicinal chemists in these heterocyclic rings has grown exponentially especially, for cancer therapy. In this project, the first synthesis of pyrazole-fused isoquinoline-5,8-diones has been developed. 1,3-Dipolar cycloaddition followed by oxidative aromatization, established by our research group, has been employed. Screening of reaction conditions and chara

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Books on the topic "Pyrazolone derivatives"

1

Wiley, Richard H., and Paul F. Wiley. Pyrazolones, Pyrazolidones, and Derivatives. Wiley & Sons, Incorporated, John, 2009.

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Wiley, Richard H., and Paul F. Wiley. Pyrazolones, Pyrazolidones, and Derivatives. Wiley & Sons, Limited, John, 2007.

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Wiley, Richard H., and Paul F. Wiley. Chemistry of Heterocyclic Compounds, Pyrazolones, Pyrazolidones, and Derivatives. Wiley & Sons, Incorporated, John, 2008.

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Book chapters on the topic "Pyrazolone derivatives"

1

Niedenzu, Kurt, and Swiatoslaw Trofimenko. "Pyrazole derivatives of boron." In Topics in Current Chemistry. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/3-540-15811-1_1.

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Kabi, Arup K., Sattu Sravani, Raghuram Gujjarappa, et al. "Overview on Biological Activities of Pyrazole Derivatives." In Materials Horizons: From Nature to Nanomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8399-2_7.

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Kang, Hyo Sim, Sun Wha Oh, and Young Soo Kang. "Comparison of Optical Properties of Pyrazoline Derivative Nanoparticles." In Solid State Phenomena. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/3-908451-27-2.39.

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4

Swarts, Steven G., Mei Zhang, Liangjie Yin, et al. "Antioxidant Properties of Select Radiation Mitigators Based on Semicarbazone and Pyrazole Derivatives of Curcumin." In Oxygen Transport to Tissue XXXII. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-7756-4_39.

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Safi, Zaki S., Mohammed H. Rida, and Hassan M. Tamous. "Application of Density Functional Theory to Study the Anticorrosive Effects of Some Pyrazole Derivatives." In Corrosion Science. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003328513-4.

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Shekara, Prathima, Jyothi Kudva, Rajitha Sadashiva, and Damodara Naral. "The Corrosion Behaviour of a Pyrazoline Derivative on Mild Steel in Hydrochloric Acid Medium: Electrochemical and Quantum Chemical Investigation." In Springer Proceedings in Materials. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-3958-5_12.

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Caravatti, G., J. Brüggen, E. Buchdunger, et al. "Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase." In Anticancer Agents. American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0796.ch014.

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Angulwar, Jaman A. "Multicomponent Synthesis of 2-Substituted Derivatives of 6-Amino-5-Cyano-1,4-Dihydro-3-Methyl-1,4-Diphenylpyrano-[2,3-C]-Pyrazole Using Knoevenagel and Michael Addition." In Modern Green Chemistry and Heterocyclic Compounds. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780367276942-4.

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Kaur, Prabhjot, Urmila Berar, and Neera Raghav. "Pyrazole and Pyrazoline Derivatives as Anti-Inflammatory agents." In Heterocyclic Anti-Inflammatory Agents: A Guide for Medicinal Chemists. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815223460124010009.

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Heterocyclic compounds have provided significant contributions to the field of medicinal chemistry. Pyrazole and pyrazoline are a class of five-membered two adjacent nitrogen-containing compounds that are integral parts of a large number of commercial anti-inflammatory drugs. After an initial introduction to inflammatory response, mechanism involved therein, the chapter compiles recent synthetic schemes along with in-vivo and in-vitro studies of pyrazole and pyrazoline derivative as antiinflammatory compounds on various established and recently recognized molecular targets.

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Mukherjee, Attreyee. "Recent Developments in the Biological Activities of 2- Pyrazoline Derivatives." In Lincoln Publication. Lincoln Publication, 2024. http://dx.doi.org/10.31674/book.2024ecc.009.

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Pyrazolines, a significant class of heterocyclic compounds, have gathered attention in medicinal chemistry for their diverse biological activities. In recent years, scientists have explored structural modifications, leading to pharmacologically active derivatives incorporated into therapeutic agents. 2-pyrazoline scaffold is found to be present in various important drug molecules e.g antipyrine, phenylbutazone, oxyphenbutazone, ibipinabant, ramiphenazone etc. 2- Pyrazoline derivatives have been reported to possess broad-spectrum biological activities such as antimalarial, antidepressant, antii

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Conference papers on the topic "Pyrazolone derivatives"

1

Pratiwi, S., and A. H. Cahyana. "Synthesis of pyrazolone derivatives compound using nanomagnetic Fe3O4 catalyst from waste cooking oil and iron rust and antioxidant activity test." In PROCEEDINGS OF THE 6TH INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN MATHEMATICS AND SCIENCES 2020 (ISCPMS 2020). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0059243.

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Muškinja, Jovana M., Jelena S. Katanić Stanković, and Zoran R. Ratković. "SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW SULFONAMIDE DERIVATIVES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.351m.

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Sulfonamide derivatives are a very important class of compounds with pronounced biological activities and, for this reason, they have very useful pharmaceutical applications. They are the basis of several groups of drugs and are known as sulfa-drugs. From this point of view, the present study focuses on the synthesis of some novel structural hybrids incorporating two very important groups, sulfonamide, and pyrazoline. The new sulfonamide-based pyrazolines were synthesized in very good yields. The structures of the sulfonamide compounds were confirmed by IR and NMR methods. Synthesized compound

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Zveaghinteva, Marina, Natalia Sucman, and Fliur Macaev. "Preparation of pyrazole class derivatives by heterocyclization of 1,2,4-triazolylethanones." In Conferința științifică națională cu participare internațională "Integrare prin cercetare și inovare", dedicată Zilei Internaționale a Științei pentru Pace și Dezvoltare. Moldova State University, 2025. https://doi.org/10.59295/spd2024n.93.

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In this work the peculiarities of the heterocyclization reaction of vinyltriazoles with the participation of hydrazine hydrate in ethanol and acetic acid are considered. Within the framework of this work it was found that the nature of the formed reaction products of the interaction of vinyltriazoles with hydrazine hydrate depends on the nature of the solvent. In boiling ethanol, 4,5-dihydro-1H-pyrazolinfunctionalized 1H-1,2,4-triazole is formed. Under acetic acid conditions, along with the formation of a pair of diastereomeric substances 4,5-dihydro-1H-pyrazoline series diastereomeric substan

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Gondek, E., J. Niziol, A. Danel, and J. Sanetra. "Photovoltaic effect based on pyrazole derivatives." In 2009 3rd ICTON Mediterranean Winter Conference (ICTON-MW 2009). IEEE, 2009. http://dx.doi.org/10.1109/ictonmw.2009.5385546.

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Janardhana, K., V. Ravindrachary, P. C. Rajesh Kumar, et al. "Third Order Optical Nonlinearity of a Pyrazoline Derivative." In THE 10TH ASIAN INTERNATIONAL CONFERENCE ON FLUID MACHINERY. American Institute of Physics, 2011. http://dx.doi.org/10.1063/1.3606354.

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Krunić, Mihajlo J., Jelena Z. Penjišević, Slađana Kostić-Rajačić, Vladimir B. Šukalović, Deana B. Andrić, and Ivana I. Jevtić. "Pyrazole/tacrine derivatives as potential cholinesterase inhibitors." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.567k.

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Two new tacrine/pyrazole conjugates were designed, synthesized, and pharmacologically evaluated for their inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A scalable and cost-efficient synthetic route was developed, and key reaction steps for the synthesis of compounds 4a,b were nucleophilic substitution of α-aroylketene dithioacetals with tacrine intermediates, followed by cyclocondensation of respective N,S-acetals with hydrazine hydrate. The preliminary pharmacological evaluation revealed high inhibitory activities of 4a,b toward AChE (180 and 259 nM

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Liu, Xiaobo, Shan Xu, and Yinhua Xiong. "Synthesis of 3-phenyl-1H-pyrazole Derivatives." In 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016). Atlantis Press, 2017. http://dx.doi.org/10.2991/emcm-16.2017.117.

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Cin, Gunseli Turgut, Seda Demirel Topel, Neslihan Nohut Maslakci, Esin Eren, and Aysegul Uygun Oksuz. "Plasma modified chitosan/N-acetyl-2-pyrazoline derivative nanofibers." In 2015 IEEE International Conference on Plasma Sciences (ICOPS). IEEE, 2015. http://dx.doi.org/10.1109/plasma.2015.7179648.

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Priyanka, S., S. Sivapriya, D. Sivakumar, M. Gopalakrishnan, M. Seenivasan, and H. Manikandan. "Synthesis and DFT calculation of novel pyrazole derivatives." In INTERNATIONAL CONFERENCE ON RECENT TRENDS IN APPLIED MATHEMATICAL SCIENCES (ICRTAMS-2020). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0063016.

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Adel, Mariam H., and Hiba H. Ibraheem. "Synthesis, molecular docking, and anti-tumor activity of pyrazole derivatives." In FIFTH INTERNATIONAL CONFERENCE ON APPLIED SCIENCES: ICAS2023. AIP Publishing, 2024. http://dx.doi.org/10.1063/5.0210692.

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