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Dissertations / Theses on the topic 'Pyrazolone derivatives'

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Published: 18 May 2024

Last updated: 25 July 2025

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1

Mariappan, G. "Cardioprotective properties of pyrazotone derivatives in myocardial ischemic reperfusion injury." Thesis, University of North Bengal, 2011. http://hdl.handle.net/123456789/1501.

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2

Vetica, Fabrizio [Verfasser]. "Organocatalytic Asymmetric Synthesis of Isochromanones, Tetranortriterpenoids and Pyrazolone Derivatives / Fabrizio Vetica." München : Verlag Dr. Hut, 2018. http://d-nb.info/1155056213/34.

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3

Motson, Graham Robert. "Coordination chemistry of 3-(2'-pyridyl) pyrazole derivative ligands." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391153.

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4

Nakhai, Azadeh. "Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives." Stockholm, 2009. http://diss.kib.ki.se/2009/978-91-7409-687-3/.

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5

Yazici, Ceyda. "Synthesis Of 4-iodopyrazole Derivatives." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609750/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The electrophilic cyclization of the acetylenic hydrazones initiated by molecular iodine could provide new ways of synthesizing biologically active 4-iodopyrazole derivatives, which are important precursors for the synthesis of highly substituted pyrazole derivatives. For this reason, we investigated the synthesis of 4-iodopyrazole derivatives, such as 1-aryl- 5-alkyl/aryl-4-iodopyrazoles, star

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6

Rango, Enrico. "PRECLINICAL CHARACTERIZATION OF SFK INHIBITORS, PYRAZOLO[3,4-d]PYRIMIDINE SCAFFOLD-BASED DERIVATIVES, FOR CANCER TREATMENT." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1140389.

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The first part of this thesis essentially focuses on the preclinical characterization of Si306, a pyrazolo[3,4-d]pyrimidine derivative, identified as a very promising anticancer agent. This compound has shown a favorable in vitro and in vivo activity profile against neuroblastoma (NB) and glioblastoma (GBM) models by acting as a competitive inhibitor of c-Src tyrosine kinase. Nevertheless, the good antitumor activity of Si306 is associated with sub-optimal aqueous solubility, which might hinder its further development. In this context, drug delivery systems were developed to overcome the poor

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7

GRECO, CHIARA. "Synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine derivatives active as SGK1, Fyn and Src kinases inhibitors." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1001600.

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The pathogenesis of many cancers is characterized by mutations, overexpression and dysregulation of protein kinases. As a result, increasing attention has been directed towards the identification of novel kinase inhibitors for cancer therapy. The work performed here focuses on the synthesis of a series of pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of the serine-threonine kinase SGK1, and the tyrosine kinases Fyn and Src. The first set of compounds are analogues of the in house SGK1 inhibitor SI113 which had previously demonstrated anti-cancer activity. In fact SI113 resulted to b

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8

Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyr

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9

Pasin, Juliana Saibt Martins. "Atividade antipirética e antiinflamatória de derivados 5-trifluormetil-4,5-diidro-1H-1-carboxiamida pirazol em ratos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/28004.

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A febre é um aumento regulado da temperatura corporal central, caracterizada por uma alteração no centro termorregulatório, a qual resulta da interação entre o sistema nervoso central e o imunológico. Enquanto a febre caracteriza lesão celular, infecção e inflamação, ela tem sido considerada o mais importante componente da resposta de fase aguda. Embora existam evidências de que a febre aumenta a defesa do hospedeiro, alguns estudos têm sugerido que o aumento da temperatura central a níveis febris pode ser prejudicial. Portanto, nas situações clínicas nas quais os riscos associados com a febre

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10

Crotti, Simone. "Computer assisted synthesis and in-vitro cytotoxic evaluation of new pyrazole-fused isoquinolinoquinones derivatives as PI3K receptor antagonist with promising antitumoral activity." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11206/.

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The importance of pyrazole and isoquinoline-5,8-dione scaffolds in medical chemistry is underlined by the high number of drugs currently on trading that contains these active ingredients. Due to their cytotoxic capability, the interest of medicinal chemists in these heterocyclic rings has grown exponentially especially, for cancer therapy. In this project, the first synthesis of pyrazole-fused isoquinoline-5,8-diones has been developed. 1,3-Dipolar cycloaddition followed by oxidative aromatization, established by our research group, has been employed. Screening of reaction conditions and chara

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11

Moura, Soraia Santana de. "Avaliação da toxicidade aguda e subaguda de um novo protótipo candidato a fármaco cardiovascular." Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tede/6958.

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Submitted by Erika Demachki (erikademachki@gmail.com) on 2017-03-16T21:37:33Z No. of bitstreams: 2 Dissertação - Soraia Santana de Moura - 2012.pdf: 3848911 bytes, checksum: 6c2c1f811c32328fc8cdb22d9edaf90a (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-03-20T13:38:54Z (GMT) No. of bitstreams: 2 Dissertação - Soraia Santana de Moura - 2012.pdf: 3848911 bytes, checksum: 6c2c1f811c32328fc8cdb22d9edaf90a (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>M

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Chandanshive, Jay Zumbar <1983&gt. "Regiocontrolled Synthesis of Pyrazole Derivatives Through 1,3-Dipolar Cycloaddition Reaction And Synthesis of Helicene-Thiourea based and Polymer Supported Soos's Catalyst for Asymmetric Synthesis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5826/1/Chandanshive_JAY_ZUMBAR_Thesis.pdf.

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In first part we have developed a simple regiocontrolled protocol of 1,3-DC to get ring fused pyrazole derivatives. These pyrazole derivatives were synthesized using 1,3-DC between nitrile imine and various dipolarophiles such as alkynes, cyclic α,β-ketones, lactones, thiocatones and lactums. The reactions were found to be highly regiospecific. In second part we have discussed about helicene, its properties, synthesis and applications as asymmetric catalyst.Due to inherent chirality, herein we have made an attempt to synthesize the helicene-thiourea based catalyst for asymmetric catalysi

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13

Chandanshive, Jay Zumbar <1983&gt. "Regiocontrolled Synthesis of Pyrazole Derivatives Through 1,3-Dipolar Cycloaddition Reaction And Synthesis of Helicene-Thiourea based and Polymer Supported Soos's Catalyst for Asymmetric Synthesis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5826/.

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In first part we have developed a simple regiocontrolled protocol of 1,3-DC to get ring fused pyrazole derivatives. These pyrazole derivatives were synthesized using 1,3-DC between nitrile imine and various dipolarophiles such as alkynes, cyclic α,β-ketones, lactones, thiocatones and lactums. The reactions were found to be highly regiospecific. In second part we have discussed about helicene, its properties, synthesis and applications as asymmetric catalyst.Due to inherent chirality, herein we have made an attempt to synthesize the helicene-thiourea based catalyst for asymmetric catalysi

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14

Nesfu, Nadirah Zawani Binti Mohd. "Les études sur les fruits de Momordica charantia et la synthèse de dérivés de benzylidène indanone pyrazolyl substitués comme inhibiteurs de la protéase NS2B/NS3 du virus de la dengue de type 2." Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0092.

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Il n'existe pas de thérapies curatives ou préventives de la dengue (DF). Seuls des soins médicaux complémentaires et une thérapie par les fluides sont disponibles pour lutter contre la dengue. Certains patients optent pour des mesures de prévention et de traitement utilisées par les peuples anciens ou des remèdes populaires pour traiter la maladie. L'un des remèdes populaires utilisés par les patients atteints de dengue à l'hôpital de Malaisie est la consommation de soupe de viande de grenouille au melon amer (Momordica charantia). La chair des fruits et les graines du Momordica charantia (M.

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15

Xu, Zhan-Zhong, and 許占中. "Synthesis of azamerocarbocyanine dyes from pyrazolone derivatives." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/48609096380898483033.

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16

Chung, Shi Chan, and 許占中. "Synthesis of azamerocarbocyanine dyes from pyrazolone derivatives." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/64588963452708359594.

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碩士<br>國立臺灣科技大學<br>纖維及高分子研究所<br>86<br>The pyrazolone derivatives were prepared by the reaction of ethyl acetoacetatewith hydrazine hydrate,methylhydrazine and phenylhydrazine,respectively.Theazamerocarbocyanine dyes were synthesised from pyrazolone intermediates and1,3,3-trimethyl-2-methylene indoline.The structure of the dyes was confirmedby E.A,IR,MS,H-NMR spectral analysis.Azamerocarbocyanine dyes were applied to dying on polyester fabrics and shown red to reddish-purple hues.The sublimation and light fastness of dyes on pol-yester fabrics were measured and shown in the range among 3-5 gra

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17

ATZORI, ELENA MARIA. "Design, synthesis and antiviral evaluation of pyrazole and pyrazoline derivatives as novel inhibitors of flavivirus and pestivirus replication." Doctoral thesis, 2017. http://hdl.handle.net/11573/931038.

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The Flaviviridae family represents a large group of viral pathogens which are divided, according to the current taxonomy, in four genera: Flavivirus (type spe¬cies, yellow fever virus (YFV)), Hepacivirus (type species, hepatitis C virus (HCV)), Pestivirus (type species, bovine virus diar¬rhea (BVDV)) and Pegivirus (type species, hepatitis G virus (HGV)). Despite the majority of these viruses are responsible for a wide range of severe diseases in humans and animals, specific antiviral therapies are currently available only for the treatment of HCV infections. The global, social and economic imp

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18

Yu-TsungLiu and 呂侑聰. "Novel Pyrazole Derivatives for Treating Osteoporosis." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ew9k4v.

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碩士<br>國立成功大學<br>生物化學暨分子生物學研究所<br>106<br>Osteoporosis is known as an age-related disease that result from an imbalance between the generation and decomposition of the bone matrix. It is caused by either the degeneration of osteoblasts leading to weaker bone forming activity or the promotion of osteoclasts increasing bone resorption activity. To treat osteoporosis, several drugs are available now. However, there are still some drawbacks of the drugs such as many side effects and high cost. According to the situation, we would like to research and synthesize new compounds to treat osteoporosis.

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19

Dash, Binay Kumar. "Microwave assisted pyrazole derivative synthesis." Thesis, 2007. http://ethesis.nitrkl.ac.in/4365/1/d.pdf.

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In the past few decades, many significant advances in organic chemistry, such as the novel synthetic reagents and methods, as well as the advent of an array of analytical apparatus and techniques, have made the organic synthesis more dynamic and effective than ever before. However, the practical aspects for carrying out laboratory-scale reactions have changed little during this period. Especially when heating is necessary, oil baths and heating jackets are the main equipment used. These traditional heating techniques are slow and time-consuming, and sometimes can lead to overheating and decomp

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20

Tsai, Meng-Ju, and 蔡孟儒. "Design and Synthesis of 1,3-Diaryl Pyrazole Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/4v24x2.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>102<br>In recent years, with the evolution of bacteria and abuse of antibiotics, bacteria’s resistance to drugs becomes an important issue in the chemotherapy. Therefore, search for newer and stronger antibiotics are becoming more and more urgent. The present research describes preparation and evaluation of certain novel agents by using 1,3 - diaryl pyrazole as a core structure, introducing various substituent on the C-4 position and the para position of the C-1 aromatic ring. These compounds were evaluated in vitro against S.aureus. Results indicated that rhodani

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21

Chen, Tsai Pi, and 蔡弼丞. "Synthesis and Characterization of pyrazolo[1,5-a] Pyrimidine Derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/73267789211679603689.

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碩士<br>國立臺灣科技大學<br>高分子工程系<br>92<br>ABSTRACT In this study, 4-arylazo-3,5-diaminopyrazole compounds have been synthesized by reaction of arylazomalononitrile with hydrazine hydrate. The symmetrical and asymmetrical 3,6-diarylazo-2,5,7- triaminopyrazolo[1,5-a]pyrimidine heterocyclic disazo dyes have been prepared by the cyclization of 4-arylazo-3,5-diaminopyrazoles with different arylazomalononitriles. The solvatochromic behaviour of these disazo dyes in various solvents was evaluated. The structures of these compounds were determined by spectrometry（UV、FT-IR、1H-NMR）and element analys

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22

Ke, Fang-Ying, and 柯方盈. "Studies on the Syntheses of Pyrazoline､Thiazoline Derivatives and their Antimicrobial､Antioxidative Activity." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/06836031465387714444.

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碩士<br>南台科技大學<br>化學工程系<br>91<br>Many heterocyclic compounds have been known for special physiological activity. Therefore, sydnonyl-substituted pyrazolines, thiazolines and thiazolidines were synthesized in this study. The text is divided into two parts: In the first part, the sydnonyl-substituted pyrazoline derivatives were prepared successfully through the reactions of sydnonyl-substituted α, β-unsaturated ketones and hydrazine hydrate. The new series of sydnonyl-substituted pyrazolines were evaluated for their antimicrobial activity. The results indicated that the antifungal activity of thes

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23

Chun-YenChen and 陳俊言. "Development of New Synthetic Methodologies for Guanidine and Pyrazole Derivatives." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/80255199794902181722.

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博士<br>國立成功大學<br>化學系碩博士班<br>98<br>The guanidinium group is present in many natural and synthetic biologically active compounds. Due to its broad spectrum of activity, the guanidine unit has been intensively studied as a synthetic goal and a diversity of new methods has been developed. Cyanamides are important precursors in the synthesis of guanidines. They also exhibit apparent tumor growth inhibition activity. Many of reagents are developed as a cyano cation (CN+) agent to synthesize the cyanamide products. Although their syntheses are straightforward, they do not produce quantitative yields a

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Carreira, Ana Rita Futre. "Synthesis and evaluation of novel pyrazole derivatives for cytotoxic activity." Master's thesis, 2018. http://hdl.handle.net/10773/24248.

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The growing number of cancer patients worldwide has led the scientific community to strengthen research efforts in this field. The development of novel drug candidates for cancer treatment has been largely studied. Among these, pyrazoles derivatives are a promising class for their wide range of pharmacological activities, including antitumoral action. This work describes the preparation of (E)-3(5)-(2-hydroxyphenyl)-4-styryl-1H-pirazole derivatives, either by glycosylation reactions or by the formation of ruthenium trithiacyclononane complexes. The new compounds aim at having antitumoral acti

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Chiou, Yu-Ting, and 邱昱婷. "Efficient Synthesis of Pyrazole Derivatives in a Continuous Flow System." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/63872017113267319198.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學系碩士班<br>105<br>Ynones are considered as highly reactive molecules and have been widely used in modern synthetic organic chemistry. There are various methods for synthesis of ynones which usually take a long time. The feature with continuous flow system is to derive desired compound in a very short period due to the unstable reactive intermediate being able to transferred to another location before their decomposition and allowed to react with another reactive reagent. Thus, the synthesis of pyrazole from phenylacetylene or the derivatives as the starting materials, w

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26

Wang, Li-Ya, and 王麗雅. "Synthesis of 1,2,4-triazole and pyrazole derivatives and biological activity study." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/20653168332065861292.

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27

Liu, Wei-Hsin, and 劉瑋鑫. "Dye-sensitized Solar Cell Based on Pyrazolate Ru(II) Complexes and Triphenylamine Derivatives." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/94741096946004249987.

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博士<br>國立臺灣大學<br>化學研究所<br>96<br>Chapter 1~2. New Family of Ruthenium-Dye-Sensitized Nanocrystalline TiO2 Solar cell A new series of ruthenium complexes with tridentate bipyridine-pyrazolate ancillary ligands has been synthesized in an attempt to elongate the π-conjugated system as well as to increase the optical extinction coefficient, possible dye uptake on TiO2 and photostability. As for the DSSC application, it was found that the complexes possess highly conversion efficiency under standard AM 1.5 irradiation (100 mW cm-2). Chapter 3. Strategic Design and Synthesis of Novel Trident Bipyridi

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Kuo, Ting-Hao, and 郭廷濠. "Novel Pyrazole Derivatives Effectively Inhibit Osteoclastogenesis, a Potential Target for Treating Osteoporosis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/02135079789878535306.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>103<br>As human beings live longer, age-related diseases such as osteoporosis will become more prevalent. Intolerant side effects and poor responses to current treatments are observed. Therefore, novel effective therapeutic agents are greatly needed. Here, pyrazole derivatives were designed and synthesized, and their osteoclastogenesis inhibitory effects both in vitro and in vivo were evaluated. The most promising compound 13 with a 2- (dimethylamino)ethyl group inhibited markedly in vitro osteoclastogenesis as well as the bone resorption activity of osteoclasts. Comp

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Tsai, Shao-Ling, та 蔡韶玲. "β-Diketone, Pyrazole and Isoxazole Derivatives with Polar Groups: Liquid Crystalline and Thermodynamic Properties". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/66543881468988295014.

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碩士<br>國立中央大學<br>化學研究所<br>95<br>In this serie, we report the synthesis, characterization and mesomorphic properties of two series of new mesogenic derivatives based on pyrazole and isoxazole structures. All compounds were characterized by 1H, 13C-NMR spectroscopy and elemental analysis. The phase behaviors of these mesogenic compounds were characterized and studied by differential scanning calorimeter (DSC) and polarization optical microscope. In serie one, a new type of mesogenic compounds derived from heterocyclic pyrazole and isoxazole (Iz-Cn) were prepared and studied. All compounds exhibit

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Chang, En-Ming, and 張恩銘. "Development and Application of Pyrazole Derivatives in Medicinal Syntheses and Organic Light-Emiting Diodes." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/77416158491514837742.

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博士<br>國立成功大學<br>化學系碩博士班<br>96<br>In this thesis, we developed the new synthesis and application for pyrazole-based derivatives as the DHODase inhibitors, and the organic electronic-transporting and electronic-hole electroluminescent materials derivatives. In the first part, we developed a new efficient and convenient synthetic method from 3-(p-aryl)-4-cyanosydnone for Pyrazole-based DHODase inhibitors via chemoselective 1,3-diploar cycloaddition, amidation, and Ritter reaction. Overall yields was in 51–60% yield in three steps. In the second part, 1,3,4-oxadiazole-based pyrazole derivatives

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Zhong, Ren Hua, and 鍾仁華. "Studies on the reaction of ��-chloroformylarylhydrazine hydrochloride with pyrazole, imidazoles and 1,2,4-triazoles derivatives." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/85706865936867611512.

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Lin, Chi-Jen, and 林祺臻. "Studies on the Synthesis and Light-Emitting Properties of Pyrazole Derivatives Including 1,3,4-Oxadiazole." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/14058259639664843553.

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碩士<br>國立成功大學<br>化學系碩博士班<br>93<br>Organic materials have been expected to be applicable for practical electroluminescent (EL) devices because of their high florescence efficiency and semiconducting properties. One of the most fascinating advantage of organic materials is the possibility of a wide selection of emission colors, particularly in the blue region, in EL displays through molecular design of organic materials. In this study, we explored a series of new blue emission materials. 　　Compounds derived from 1,3,4-oxadiazoles had been reported having good electron-transporting properties and

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Chen, Shiang-Chi, and 陳祥麒. "Microwave-mediated cycloaddition of 1,3-diphenylprop-2-yn-1-one to pyrazole and naphothofuran derivatives." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/27362676310213208760.

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碩士<br>國立臺灣師範大學<br>化學系<br>103<br>This thesis is divided into three chapters. The first Chapter illustrates a convenient procedure for the one-pot synthesis of pyrazole derivatives. In this strategy, the initial step is the Michael addition of morpholine to 1,3-diphenylprop-2-yn-1-one to form an intermediate, and followed by the cycloaddition with phenylhydrazine under acidic condition. Here, we disclosed the reaction in traditional heating as well as microwave heating method. Chapter two, discribes the method for the synthesis of pyrazole under “on water” condition, supported by microwave heati

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Sengupta, Satirtha. "Studies on Metal-Organic Frameworks and Metallogels of Pyrazole based ligands and their Amide Derivatives." Thesis, 2019. http://hdl.handle.net/10821/8220.

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Metal-organic frameworks (MOFs) or coordination polymers are one, two or three dimensional coordination networks, usually porous, comprising of metal ions linked together with one or more organic ligand or linker molecules having varied applications in the field of gas storage and separation, magnetism, catalysis etc. However there is a subtle difference in the definition of the term coordination polymers and metal organic frameworks. The former merely signifies an extended network formed due to coordination bond between metal and ligand(s) monomers and says nothing about the final structure o

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Hsu, Ya-Shu, та 許雅淑. "The study of pyrazolo[4,3-c]quinoline derivatives as inhibitor of p38α MAPK by computer molecular modeling". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/21523131607051410483.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所碩士在職專班<br>97<br>This study analyses and modifies the model of Accerlys Discovery Studio with the pyrazolo[4,3-c]quinoline derivatives as inhibitor of p38α MAPK by computer molecular modeling. From this study we intend to find novel molecule to be potential anti-infection P38 MAPK inhibitors. The results of this study led to the discovery of 13 possible compounds which we have further predict their activities and the pharmacophore. Although preious studies suggested three amino acids involved in the interaction of typical p38α MAPK inhibitors, we have found the forth a

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JHANG, JIA-WEI, and 張家瑋. "Part 1: Design and Attempted Synthesis of Acridone Derivatives as Potential ABC Transporters Inhibitors,Part 2: Design and Synthesis of Pyrazole Derivatives as System xc- Inhibitors." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/qg9258.

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碩士<br>東海大學<br>化學系<br>105<br>Part 1: ABC(ATP-binding cassette) transporter proteins are responsible for the cellular efflux of metabolites or toxic substances to protect cells. Overexpression of ABC transporter protein occur when tumor cells are stimulated continuously by chemotherapeutic drugs,that to causing lack of drug accumulation drugs which lead to development of multidrug resistance (MDR). The development of MDR is a major obstacle to successful chemotherapeutic treatment of cancer patients. Acridones are naturally occurring alkaloids and one of its derivatives, Elacridar was shown to

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Lee, Cheng-Tien, and 李承典. "Studies on Synthesis and Light-Emitting Properties of ConjugatedPoly(p-phenylenevinylene) Derivatives Containing Pyrazole and 1,3,4-Oxadiazole Rings." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/67855487208244512188.

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碩士<br>國立成功大學<br>化學系碩博士班<br>94<br>Six poly(p-phenylenevinylene) derivatives, P1~P2 with oxadiazole along the main chain and P3~P6 bearing two 1,3,4-oxadiazole rings and pyrazole rings from sydnone along the main chain were synthesized via Heck coupling. The new polymer are studied on their structure,physical and photoelectronic properties. 　The polymers dissolved readily in common organic solvents and had high glass-transition temperature values of 149°C ~ 167 °C for P3 ~P6.They were stable up to approximately 260°C ~ 350°C in N2 and the anaerobic char yield was around 28 ~ 35% at 800 °C except

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Chang, En-Chiuan, and 張恩銓. "Synthesis of the Pyrazole Derivatives Containing Carbazole and 1,3,4-Oxadiazole Rings and Applied to Organic Electro-Luminescence Devices." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/60169640570777845151.

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碩士<br>國立成功大學<br>化學系碩博士班<br>95<br>In this study, I had synthesized a series of pyrazole derivatives, and applied in organic electro-luminescence devices. The series of pyrazole derivatives were all synthesized from sydnone via 1,3-dipolar cycloaddition. Organic light-emitting diode (OLED) is a novel technology. The large size display can be made via this technology. Because of some organic materials have high fluorescence efficiency and semiconducting properties, they often applicable to electro-luminescence (EL) devices. The other hand, the emission colors can be determine via modify organic

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Goswami, Arijit. "Studies on Coordination Complexes Metal Organic Framework (MOFs) and Network using Salicylic Acid Derivatives and Pyrazole based Ligand." Thesis, 2019. http://hdl.handle.net/10821/8222.

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The whole work is divided in three parts. The 1st part deals with synthesis if series of metal organic framework from bis-pyrazole ligands and various aromatic carboxylic acids and their potential application. the 2nd part contains synthesis and investigation of energy parametres of supramolecular framework resulting from the combination between a bispyrazole ligand and inorganic anions. The 3rd part and the final part contains synthesis of diverse metal organic framework and metal complexes based on chloro-salicyclic acid.<br>Research was carried out under the supervision of Dr. Raju Mondal o

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Tsai, Pi-Chen, and 蔡弼丞. "Synthesis and Solvatochromic Properties of Some Novel Symmetrical and Asymmetrical Heterocyclic Disazo Dyes Based on Pyrazolo[1,5-a]Pyrimidine Derivatives." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/49g7pn.

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博士<br>國立臺灣科技大學<br>高分子系<br>95<br>The disertation consists of two main themes: Firstiy, (1) 3,5-Di-(amino or methyl)-4-substituted-azoly-pyrazole and 3-amino-5- methyl-4-substituted-azoly-pyrazole have been synthesized via the cyclization from hydrazine hydrate with 2-substituted-azoly-malono- nitrile, 3-sub-stituted-azoly-pentane-2,4-dione and 3-imino-2-substitu- ted-azoly-butyronitrile, respectively; and (2) 5-amino-3-methyl-4-substi -tuted-azoly-pyrazole and 3-amino-4-substituted-azoly-5-pyrazolone were prepared by coupling reaction of aniline derivatives with 3-amino-5-pyrazolone and 5-amino

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Wu, Hong-Jhou, and 吳宏洲. "Synthesis of Pyrazolo[1,5-a]pyridine Derivatives via Hydrazine and 4-ene-2,6-diyne-one by Copper(I) chloride-catalyzed." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/38283112889469025155.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所碩士班<br>95<br>Recently, we developed synthetic methods to a series of aromatic compounds such as isoquinolones, phenanthridinones, and biphenyls via anionic cycloaromatization of enediynes. We found that treatment of (Z)-1-phenyltrideca-4-en-2,6-diyn-1-one (78b) with 5 eq hydrazine and 4 eq copper(I) chloride in refluxing CH3CN afforded pyrazolo[1,5-a]pyridine (81) in 85 % yield.

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Su, Wei-Nien, and 蘇威年. "Convenient and Efficient“One-pot”Synthesis of N-(1,3-Diphenyl-1H-pyrazole-5-yl)amide Derivatives: Positive allosteric Modulators of mGluR5." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/14099096043064355484.

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碩士<br>中國醫藥大學<br>藥物化學研究所<br>96<br>Glutamate is the major excitatory transmitter in the mammalian central nervous system. Metabotropic glutamate receptors (mGluRs) play an important role in controlling neuronal excitability and synaptic transmission in the central nervous system (CNS) of the mammalian brain. N-(1.3-Diphenylare1-H-pyrazol-5-yl)benzamide derivatives were recently developed as the first centrally active positive allosteric modulator of rat and human metabotropic glutamate receptor mGluR5 subtype. N-(1,3- diphenyl-1H-pyrazol-5-yl)amide derivatives were convenient and efficient synth

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陳孟榆. "Pyrazole Calix[4]arenes as Highly Selective Fluorogenic Sensors for Silver (I) and Mercury (II) and Synthesis of Pillar[5]arene Derivatives." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/04499796060226609005.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>99<br>This study is divided into two parts. First, two series of lower-rim modified calix[4]arene with pyrazole substituents were synthesized. Using phenyl pyrazole calix[4]arenes as basic synthesis frameworks, we synthesized phenylanthryl pyrazole calix[4]arenes 76 and 77 and control compounds 78 and 79 as fluorogenic ions sensors. Based on the results from UV-Vis, fluorescence and 1H-NMR spectrometry, we found that pyrazole calix[4]arenes 77 and 79 recognized Ag+ and Hg2+ with excellent selectivity in MeOH/CHCl3 (v/v = 4:1), respectively. Compound 77 induced 141%

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Chou, Li-Chen, and 周立琛. "Synthesis and anticancer activity of 1,3,5-substituted selenolo[3,2-c]pyrazole analogues、Synthesis and anticancer activity of hydrophilic phosphate prodrugs of 2-phenyl-4-quinolone derivatives." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/72588313584030324230.

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博士<br>中國醫藥大學<br>藥物化學研究所博士班<br>97<br>The purpose of this study is to develop compounds with potential anticancer activity as new drug candidate. This thesis consists of two parts. In the first part, four different skeletons of YC-1 derivatives [furopyrazole derivatives (11-22, 28-36), thienopyrazole derivatives (42-45, 50-53), selenopyrazole derivatives (67-72, 75-77), and indazole derivatives (99−118, 123−128)] were synthesized in order to expand the substance patent’s inclusion of YC-1 and find new candidate with better anticancer activity than YC-1, and constructed their SAR in NCI-H226 and

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Cardoso, Inês Sofia Soares Gomes Lains. "Design and synthesis of a novel pyrazolopyrimidine compound as a potential kinase inhibitor." Master's thesis, 2016. http://hdl.handle.net/10451/34606.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Cancer is a generic term for a group of diseases in which abnormal cells have a fast and uncontrolled growth and proliferation, invading neighbouring tissues and spreading to parts of the body different from where it started. Cancer is placed second at the most important causes of death and morbidity in Europe and accounts for 1 in every 7 deaths worldwide, which is more than HIV, tuberculosis and malaria combined. Furthermore, the number of new cases worldwide is expected to r

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Chang, Chun-Hsi, and 張濬璽. "The study of selective synthesis and biological activity of pyrazolo[3,4-d]pyrimidine, N-(1H-pyrazol-5-yl)formamide, or N-(1H-pyrazol-5-yl)formamidine derivatives from N-1-Substituted-5-aminopyrazoles with new Vilsmeier-type reagents." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/95634777776867134802.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>102<br>Various halomethyleniminium salts as novel Vilsmeier reagents were synthesized from the reaction of formamide or N-methylformamide with phosphoryl chloride. Treatment of N-1-substituted-aminopyrazoles including, N-1-(2-pyridinyl)-5-aminopyrazoles and N-1-(2-quinolinyl)-5-aminopyrazoles with these Vilsmeier reagents to obtain the corresponding pyrazolo[3,4-d]pyrimidine, N-(1H-pyrazol-5-yl)formamide, or N-(1H-pyrazol-5-yl)formamidine products. The experimentant results were different with our previous data which the formylated amidylpyazole and formamidine pr

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