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Journal articles on the topic 'Pyridazyl'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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1

Yang, Wu, Leixia Fu, Jie Wu, and Chuanjun Song. "Synthesis of pyrrol-pyridazyl-triazolyl-pyridines via Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction." Synthetic Communications 46, no. 13 (2016): 1118–23. http://dx.doi.org/10.1080/00397911.2016.1185123.

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2

Farouk, Maha, Lobna A. Hussein, and Noha F. El Azab. "New HPLC and Fluorometric Methods for the Determination of Pyriproxyfen and Pyridalyl Insecticide Residues in Tomatoes." Journal of AOAC INTERNATIONAL 97, no. 1 (2014): 188–96. http://dx.doi.org/10.5740/jaoacint.12-354.

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Abstract Two sensitive, selective, and precise methods for the determination of pyriproxyfen and pyridalyl insecticide residues in tomatoes have been developed. The first method is HPLC with UV detection in which pyriproxyfen and pyridalyl were extracted with ethyl acetate and acetone, respectively, followed by cleanup using column chromatography. The recoveries ranged from 86.03 to 94.55 for pyriproxyfen and 95.08 to 99.38% for pyridalyl in tomato samples. The LOD of the method was 0.217 ppmfor pyriproxyfen and 0.1866 ppm for pyridalyl. The second method depends on direct fluorometric determi

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3

Konečný, Václav, and Štefan Kováč. "A New Electrophilic Rearrangement." Collection of Czechoslovak Chemical Communications 61, no. 3 (1996): 437–41. http://dx.doi.org/10.1135/cccc19960437.

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4

Konečný, Václav, Jozefína Žúžiová, Štefan Kováč, and Tibor Liptaj. "Synthesis of Novel 4-Amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones." Collection of Czechoslovak Chemical Communications 62, no. 5 (1997): 800–808. http://dx.doi.org/10.1135/cccc19970800.

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Substituted 4-amino-2-phenyl-2H-pyridazin-3-ones 5a-5j have been prepared from 4-amino-5-chloro-2-phenyl-2H-pyridazin-3-one 1 which on reactions with acetyl chloride or acetic anhydride gives 4-acetylamino derivative 2 or 4-diacetylamino derivative 3, respectively. Derivatives 2 and 3 with dialkylamines and cyclic amines yielded appropriate 4-acetylamino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones 4a-4j. Subsequent alkaline hydrolysis of the acetylamino derivatives 4a-4j let to the title compounds 5a-5j, which were screened for pesticidal activity, but none of them reached activity of

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5

Barlin, GB, and SJ Ireland. "Imidazo[1,2-B]pyridazines. II. 6-Alkylthio and 6-Arylthio-3-methoxy-2-phenylimidazo[1,2-b]pyridazines." Australian Journal of Chemistry 40, no. 8 (1987): 1491. http://dx.doi.org/10.1071/ch9871491.

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A series of 6-alkylthio- and 6-arylthio-3-methoxy-2-phenylimidazo[l,2- b]pyridazines has been prepared from 6-alkylthio-and 6-arylthio-pyridazin-3-amines through the corresponding 6-alkylthio-and 6-arylthio-2-phenylimidazo[l,2-b] pyridazin-3(5H)-ones.

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6

Wang, Lingling, Yuting Nie, Yujiao Wang, Zhenyu Wang, and Bo Xiong. "Qualitative and quantitative determinations of pyridalyl and metabolites in excrement of two representative Lepidoptera pests." RSC Advances 5, no. 125 (2015): 103474–79. http://dx.doi.org/10.1039/c5ra21984a.

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Qualitative and quantitative SPE followed by HPLC-TOF/MS determination of pyridalyl and its potential metabolites in the excrement of Helicoverpa armigera (H. armigera) and Spodoptera exigua (S. exigua) was developed.

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7

Miller, Donnie K., Robert G. Downer, Eugene Burris, John W. Wilcut, and Donald R. Cook. "Trifloxysulfuron–Insecticide Combination Effects on Broadleaf Weed and Thrips (Frankliniella spp.) Control in Cotton." Weed Technology 19, no. 3 (2005): 762–67. http://dx.doi.org/10.1614/wt-04-323r.1.

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Coapplication of herbicides and insecticides affords growers an opportunity to control multiple pests with one application given that efficacy is not compromised. Trifloxysulfuron was applied at 5.3 g ai/ha both alone and in combination with the insecticides acephate (370 g ai/ha), oxamyl (370 g ai/ha), lambda-cyhalothrin (34 g ai/ha), acetamiprid (45 g ai/ha), thiamethoxam (45 g ai/ha), endosulfan (379 g ai/ha), indoxacarb (123 g ai/ha), emamectin benzoate (11 g ai/ha), methoxyfenozide (67 g ai/ha), spinosad (75 g ai/ha), and pyridalyl (112 g ai/ha) to determine the effects of coapplication o

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8

El-Kousy, Salah, Ibraheim El-Sakka, Abdel Monem El-Torgoman, Hesham Roshdy, and Mohamed Hilmy Elnagdi. "Synthesis of new polyfunctionally substituted pyridazines, phthalazines, cinnolines and thieno[3,4-c]pyridazines." Collection of Czechoslovak Chemical Communications 55, no. 12 (1990): 2977–86. http://dx.doi.org/10.1135/cccc19902977.

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The reaction of ethyl 2-arylhydrazono-3-oxobutyrates (Ia, Ib) with active methylene ketones afforded pyridazin-5-carbonitrile derivatives. The methyl function in the ethyl pyridazin-3-carboxylate derivatives IIa, IIb reacted with arylidenemalononitrile to yield the phthalazine derivatives Va-Vf and with elemental sulfur to yield the thienopyridazines XIXa, XIXb. The cinnolines are producted from reaction of IIa, IIb with diethyl acetonedicarboxylate.

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9

Barlin, GB. "Imidazo[1,2-B]Pyridazines. I. Some 3-Alkoxy-6-Halogeno-2-Phenyl-(and 4′-Substituted Phenyl)Imidazo[1,2-B]Pyridazines and 3-Methoxy-2,6-Diphenylimidazo[1,2-B]Pyridazine." Australian Journal of Chemistry 39, no. 11 (1986): 1803. http://dx.doi.org/10.1071/ch9861803.

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A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl) imidazo [1,2-b] pyridazines (1) and 3-methoxy-2,6- diphenylimidazo [1,2-b] pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O- alkylation of the corresponding imidazo [1,2-b]pyridazin-3(5H)-ones with diazoalkanes. 6- Chloro-3-methoxy-2-phenylimidazo[2,1-a] phthal-azine was prepared similarly.

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10

Samanta, Kartick Chandra, Mohd Asif, Pooja, Vikas Garg, Priyanka Sharma, and Ravinder Singh. "Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity." E-Journal of Chemistry 8, no. 1 (2011): 245–51. http://dx.doi.org/10.1155/2011/873470.

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6-Phenyl(3᾽-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3᾽-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriateβ-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity.

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11

Park, Ji-Su, Seung-Hyun Yang, and Hoon Choi. "Residue Patterns and Biological Half-lives of Pyridalyl and Fluopicolide in Watermelon." Korean Journal of Environmental Agriculture 36, no. 1 (2017): 50–56. http://dx.doi.org/10.5338/kjea.2017.36.1.08.

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12

Nagahori, Hirohisa, Yoshitaka Tomigahara, Naohiko Isobe, and Hideo Kaneko. "Metabolism of Pyridalyl in Rats: Excretion, Distribution, and Biotransformation of Dichloropropenyl-Labeled Pyridalyl." Journal of Agricultural and Food Chemistry 57, no. 22 (2009): 10845–51. http://dx.doi.org/10.1021/jf9026469.

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13

Sakamoto, Noriyasu, Taro Hirose, Shigeru Saito, and Kimitoshi Umeda. "Discovery and development of pyridalyl." Journal of Pesticide Science 37, no. 3 (2012): 265–66. http://dx.doi.org/10.1584/jpestics.j12-04.

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14

Nagahori, Hirohisa, Koichi Saito, Yoshitaka Tomigahara, Naohiko Isobe, and Hideo Kaneko. "Metabolism of Pyridalyl in Rats." Drug Metabolism and Disposition 37, no. 12 (2009): 2284–89. http://dx.doi.org/10.1124/dmd.109.028878.

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15

Cablewski, Teresa, Erin J. Carter, Craig L. Francis, Andris J. Liepa, and Michael V. Perkins. "N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. III. Pyrido- and Pyridazo-Fused [1,2,4,6]Thiatriazine Dioxides." Australian Journal of Chemistry 60, no. 2 (2007): 105. http://dx.doi.org/10.1071/ch06367.

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N,N-Dialkyl-N′-chlorosulfonylchloroformamidines 1 reacted with 2-aminopyridines 2 to give novel pyrido[1,2-b][1,2,4,6]thiatriazine dioxides 3 and pyrido[2,1-c][1,2,4,6]thiatriazine dioxides 4. Reaction of 1 with 3-aminopyridazines 5 afforded pyridazo[3,2-c][1,2,4,6]thiatriazine dioxides 6 and a pyridazo[2,3-b][1,2,4,6]thiatriazine dioxide 7. The compounds 6 and 7 are derivatives of new ring systems.

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16

El-Dean, Adel M. Kamal, Shaban M. Radwan, and Yasser A. Elosealy. "Synthesis of some new imidazo[3″,4″:1′,2′] pyrimido[4′,5′:4,5]thieno[2,3-c] pyridazines and other fused thieno[2,3-c]pyridazines." Journal of Chemical Research 2008, no. 11 (2008): 622–25. http://dx.doi.org/10.3184/030823408x371056.

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5-Amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide was prepared and used as starting material to form the novel 6-chloromethyl-3,4-diphenylpyrimido[4′,5′:4,5]thieno[2,3-c]pyridazin-8(7H)-one (3), the 6-(arylaminomethyl) compounds (4a–c), 7-aryl-7,8-dihydro-3,4-diphenylimidazo[3″,4″:1′,2′]pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazin-10(6H)-ones (5a–c), ethyl 7,8-dihydro-8-oxopyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-6-acetate (6) and its carbohydrazide (7). The pyridazinothienopyrimidotriazepinedione 8, pyridothienopyridazine 12 and pyridazinothienooxazepine 13 were also prepared.

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17

Schmitt, Martine, Jean-Jacques Bourguignon, Gordon B. Barlin, and Les P. Davies. "Imidazo[1,2-b]pyridazines. XXIV Syntheses of Some 3-(Variously Substituted) Imidazo[1,2-b] pyridazines, 6-Substituted 2-Benzoyl- imidazo[1,2-b]pyridazines and Pyrimido[1,2-b]pyridazin- 5-ium-3-olates and their Interaction with Central and Mitochondrial Benzodiazepine Receptors." Australian Journal of Chemistry 50, no. 8 (1997): 779. http://dx.doi.org/10.1071/c97030.

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The syntheses of some ethyl 2-{2′-aryl-6′-(chloro, iodo and methoxy)imidazo[1,2-b]pyridazin-3′-yl}-2-(acetoxy, acylamino, hydroxy and methoxy)acetates, 6-methyl-2-(p-tolyl)- and 6-chloro-2-(4′-chlorophenyl)-3-trimethylammoniomethylimidazo[1,2-b]pyridazine iodides (and reactions thereof), 2-benzoyl 6-substituted imidazo[1,2-b]pyridazines and 7-(methoxy, chloro and phenylthio)-2-phenylpyrimido-[1,2-b]pyridazin-5-ium-3-olates are reported. The ability of these compounds to displace [3H]diazepam from rat forebrain membrane [central benzodiazepine receptor (BZR)] and rat kidney membrane [mitochondr

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18

Elnagdi, Mohamed Hilmy, Fatma Abdul Maksoud Abdul-Aal, Nadia M. Taha та Youssef Mahfouz Yassin. "Chemistry of Alkylheterocyclic Aromatic π-Deficient Compounds: A Novel Synthesis of Cinnolines". Zeitschrift für Naturforschung B 45, № 3 (1990): 389–92. http://dx.doi.org/10.1515/znb-1990-0315.

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19

Moreau, S., P. Coudert, B. Lasserre, et al. "Pharmacophore requirements in new series of pyridazinyl alkanoic acids, N-[(pyridazin-2-yl) alkyl] succinyl and glutaryl amides, inhibitors of thromboxane A2 biosynthesis." Prostaglandins, Leukotrienes and Essential Fatty Acids 56, no. 6 (1997): 431–36. http://dx.doi.org/10.1016/s0952-3278(97)90595-0.

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20

Ramadan, Mahmoud, M. El-Tantawy, M. Ashour, and R. Sherif. "PYRIDALYL INSECTICIDE RESIDUES IN TOMATO PLANTS." Zagazig Journal of Agricultural Research 43, no. 1 (2016): 245–50. http://dx.doi.org/10.21608/zjar.2016.101888.

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21

Behbehani, H., M. M. Abdel-Khalik, and M. H. Elnagdi. "NEW SYNTHESES OF SUBSTITUTED PYRIDAZIN-6-ONES AND PYRIDAZIN-6-IMINES." Organic Preparations and Procedures International 31, no. 5 (1999): 551–57. http://dx.doi.org/10.1080/00304949909355339.

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22

Sukuroglu, Murat, Tijen Onkol, Fatma Kaynak Onurdağ, Gulsen Akalın, and M. Fethi Şahin. "Synthesis and in vitro Biological Activity of New 4,6-Disubstituted 3(2H)-Pyridazinone-acetohydrazide Derivatives." Zeitschrift für Naturforschung C 67, no. 5-6 (2012): 257–65. http://dx.doi.org/10.1515/znc-2012-5-604.

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New 3(2H)-pyridazinone derivatives containing a N’-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confi rmed by IR, 1H NMR, and MS data. These compounds were tested for their antibacterial, antifungal, antimycobacterial, and cytotoxic activities. The compounds 2-[4-(4-chlorophenyl)- 6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N’-(4-tert-butylbenzyliden)acetohydrazide and 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N’-(4-chlorobenzyliden) acetohydrazide exhibited activity against both Gram-posit

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23

Toplak, Renata, Jurij Svete, Simona Golič Grdadolnik, and Branko Stanovnik. "Methyl (Z)-2-[(Benzyloxycarbonyl)amino]-3-dimethyl- aminopropenoate in the Synthesis of Heterocyclic Systems. Synthesis of (Benzyloxycarbonyl)amino Substituted Fused Pyrimidinones." Collection of Czechoslovak Chemical Communications 64, no. 2 (1999): 177–89. http://dx.doi.org/10.1135/cccc19990177.

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Methyl (Z)-2-[(benzyloxycarbonyl)amino]-3-dimethylaminopropenoate (1) was used as a reagent for preparation of 3-[(benzyloxycarbonyl)amino] substituted 4H-pyrido[1,2-a]pyrimidin-4-ones 17-21, 4H-pyrimido[1,2-b]pyridazin-4-ones 22 and 23, 5H-[1,2,4]triazolo[2,3-a]- pyrimidin-5-one 24, 5H-thiazolo[3,2-a]pyrimidin-5-one 25, and 4H-pyrazino[1,2-a]pyrimidin-4-one 26. Removal of the benzyloxycarbonyl group by catalytical transfer hydrogenation with Pd/C in the presence of cyclohexene is selective to give 3-amino-4H-pyrido[1,2-a]- pyrimidin-4-ones 27-30 in 85-92% yields, or with hydrogen bromide in a

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24

Degtyarenko, Anna S., та Konstantin V. Domasevitch. "Cadmium(II) iodide and thiocyanate complexes adopted by polycyclic 1,4-bis(pyridazin-4-yl)benzene: interplay of coordination and π–π stacking interactions". Acta Crystallographica Section C Crystal Structure Communications 69, № 3 (2013): 219–24. http://dx.doi.org/10.1107/s0108270113002801.

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New complexes containing the 1,4-bis(pyridazin-4-yl)benzene ligand, namely diaquatetrakis[1,4-bis(pyridazin-4-yl)benzene-κN2]cadmium(II) hexaiodidodicadmate(II), [Cd(C14H10N4)4(H2O)2][Cd2I6], (I), and poly[[μ-1,4-bis(pyridazin-4-yl)benzene-κ2N2:N2′]bis(μ-thiocyanato-κ2N:S)cadmium(II)], [Cd(NCS)2(C14H10N4)]n, (II), demonstrate the adaptability of the coordination geometries towards the demands of slipped π–π stacking interactions between the extended organic ligands. In (I), the discrete cationic [Cd—N = 2.408 (3) and 2.413 (3) Å] and anionic [Cd—I = 2.709 (2)–3.1201 (14) Å] entities are situat

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25

Heinisch, Gottfried, and Wolfgang Holzer. "Configurational assignment of aryl heteroaryl ketoximes by means of homonuclear NOE difference spectroscopy." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2251–57. http://dx.doi.org/10.1135/cccc19912251.

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The utility of homonuclear NOE difference spectroscopy as a simple and rapid method for the configurational assignment of aryl heteroaryl ketoximes is demonstrated employing oximes derived from 4-methoxyphenyl 2-pyrazinyl ketones, (substituted phenyl) 4-pyridazinyl ketones, and benzimidazolyl phenyl ketones.

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26

Behbehani, H., M. M. Abdel-Khalik, and M. H. Elnagdi. "ChemInform Abstract: New Syntheses of Substituted Pyridazin-6-ones and Pyridazin-6-imines." ChemInform 31, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.200011146.

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27

Sayed, Samia, Mohamed Khalil, Maghraby Ahmed, and Mohamed Raslan. "SYNTHESIS OF NEW PYRIDAZIN- 6-ONES, PYRIDAZIN-6-IMINES, 4-PYRIDAZINALS, AND PYRIDINES." Synthetic Communications 32, no. 3 (2002): 481–95. http://dx.doi.org/10.1081/scc-120002134.

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28

Mojahidi, Souad, Hanan Sekkak, El Mostapha Rakib, et al. "Alkylation and 1,3-Dipolar Cycloaddition of 6-Styryl-4,5-dihydro-2H-pyridazin-3-one: Synthesis of NovelN-Substituted Pyridazinones and Triazolo[4,3-b]pyridazinones." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/636280.

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Some newN-substituted pyridazinones and triazolo[4,3-b]pyridazinones were synthesized, respectively, by simple alkylation and 1,3-dipolar cycloaddition of pyridazin-3-one with nitrile imines. The regioselectivity of the reactions was ascertained by1H,13C NMR spectroscopy and X-ray diffraction of the synthesized compounds.

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29

Tsuchiya, Toru. "Characteristics of Pyridalyl (Pleo^|^reg;), a Novel Insecticide." Journal of Pesticide Science 30, no. 3 (2005): 278–81. http://dx.doi.org/10.1584/jpestics.30.278.

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30

Ikegami, Hiroshi, and Noriyasu Sakamoto. "Discovery of pyridalyl and development of dihalopropene insecticides." Japanese Journal of Pesticide Science 39, no. 1 (2014): 83–88. http://dx.doi.org/10.1584/jpestics.w13-33.

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31

Isayama, S., S. Saito, K. Kuroda, K. Umeda, and K. Kasamatsu. "Pyridalyl, a novel insecticide: Potency and insecticidal selectivity." Archives of Insect Biochemistry and Physiology 58, no. 4 (2005): 226–33. http://dx.doi.org/10.1002/arch.20045.

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32

Powell, Gerard F., Deborah A. Ward, Mark C. Prescott, et al. "The molecular action of the novel insecticide, Pyridalyl." Insect Biochemistry and Molecular Biology 41, no. 7 (2011): 459–69. http://dx.doi.org/10.1016/j.ibmb.2011.03.007.

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33

Rimaz, Mehdi, Jabbar Khalafy, Nader Noroozi Pesyan, and Rolf H. Prager. "A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors." Australian Journal of Chemistry 63, no. 3 (2010): 507. http://dx.doi.org/10.1071/ch09569.

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Several new 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-5-oxo-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones have been synthesized by a three-component reaction of barbituric acid or thiobarbituric acid with arylglyoxals in the presence of a catalytic amount of pyridine and hydrazine hydrate at room temperature in water.

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34

Sayed, Samia M., Mohamed A. Khalil, Maghraby A. Ahmed, and Mohamed A. Raslan. "ChemInform Abstract: Synthesis of New Pyridazin-6-ones, Pyridazin-6-imines, 4-Pyridazinals, and Pyridines." ChemInform 33, no. 26 (2010): no. http://dx.doi.org/10.1002/chin.200226162.

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35

Yoon, Ji-Young, Jae-Hun Park, Hye-Ree Moon, Guk-Tak Han, and Kyu-Seung Lee. "Residue patterns of indoxacarb and pyridalyl in treated cauliflower." Agricultural Sciences 04, no. 03 (2013): 111–16. http://dx.doi.org/10.4236/as.2013.43017.

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36

Blake, A. J., and H. McNab. "Four Simple Pyridazin-3(2H)-ones." Acta Crystallographica Section C Crystal Structure Communications 52, no. 10 (1996): 2622–27. http://dx.doi.org/10.1107/s0108270196005355.

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37

Kandile, N. G., H. T. Zaky, M. I. Mohamed, and Abdel-Sattar S. Hamad Elgazwy. "Reactivity of pyridazin-3(2H) thiones." Heteroatom Chemistry 14, no. 4 (2003): 334–41. http://dx.doi.org/10.1002/hc.10157.

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38

Heinisch, G., B. Matuszczak, S. Pachler, and D. Rakowitz. "The Inhibitory Activity of Diazinyl-Substituted Thiourea Derivatives on Human Immunodeficiency Virus Type 1 Reverse Transcriptase." Antiviral Chemistry and Chemotherapy 8, no. 5 (1997): 443–46. http://dx.doi.org/10.1177/095632029700800507.

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Starting from 2-(2-aminoethyl)pyridine, a series of N-diazinyl-N′-[2-(2-pyridyl)ethyl]thioureas was prepared via the (2-pyridyl)ethylisothiocyanate and was screened as non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors. Derivatives bearing a 3-pyridazinyl or a 4-pyrimidinyl moiety turned out to be the most potent compounds. However, they exhibited less activity than nevirapine or trovirdine.

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39

Kazimierczuk, Zygmunt, Jarosław Kamiński, and Flavio Meggio. "Studies on Improved Synthesis of 2'-Deoxyribonucleosides of Pyridazine Derivatives." Collection of Czechoslovak Chemical Communications 71, no. 6 (2006): 889–98. http://dx.doi.org/10.1135/cccc20060889.

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A number of 2'-deoxyribonucleosides of halogenated pyridazine derivatives were prepared by glycosylation of their respective potassium or DBU salts in acetone. The reaction yielded predominatly β-anomers that could be purified by simple crystallization or column chromatography. Of the studied pyridazines and deoxynucleosides, only 4-bromo-6-chloropyridazin-3-one and 6-chloro-2-(2'-deoxyribofuranosyl)pyridazin-3-one showed modest inhibition of CK2 kinase.

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40

Norman, Rebecca E., Michael V. Perkins, Andris J. Liepa, and Craig L. Francis. "N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part X. The First Pyrazolo[1,5-b][1,2,4,6]thiatriazine Derivatives and their Unusual Reactions with Acylating Agents." Australian Journal of Chemistry 66, no. 11 (2013): 1323. http://dx.doi.org/10.1071/ch13282.

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N,N-dialkyl-N′-chlorosulfonyl chloroformamidines 1 underwent a regioselective reaction with 3-aminopyrazoles 2 to produce pyrazolo[1,5-b][1,2,4,6]thiatriazines 3, representatives of a new ring system. Attempted N-acylation of compounds 3 with acetic anhydride (or chloride) and benzoyl chloride in pyridine, only afforded 5-(pyridin-4-yl)-pyrazolo[1,5-b][1,2,4,6]thiatriazine derivatives 11. The analogous reaction with pyridazine led to the corresponding pyridazin-4-yl derivative.

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41

Jones, R. Alan, and Alexander Whitmore. "The tautomeric properties of 6-(2-pyrrolyl)pyridazin-3-one and 6-(2-pyrrolyl)pyridazin-3-thione." Arkivoc 2007, no. 11 (2006): 114–19. http://dx.doi.org/10.3998/ark.5550190.0008.b10.

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42

Verhelst, Tom, Zuming Liu, Jens Maes, and Bert U. W. Maes. "Synthesis of (Hetero)arylated Pyridazin-3(2H)-ones via Negishi Reaction Involving Zincated Pyridazin-3(2H)-ones." Journal of Organic Chemistry 76, no. 23 (2011): 9648–59. http://dx.doi.org/10.1021/jo201587j.

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43

Saito, Shigeru. "Effects of Pyridalyl on ATP Concentrations in Cultured Sf9 Cells." Journal of Pesticide Science 30, no. 4 (2005): 403–5. http://dx.doi.org/10.1584/jpestics.30.403.

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44

M., Sumakanth, V. Malla Reddy, V. S. H. Krishnan, and B. S. Sastry. "Synthesis of Some New Imidazo[1,2-b] Pyridazines." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (2009): 471–76. http://dx.doi.org/10.37285/ijpsn.2009.2.1.14.

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Several 2,6-diaryl-imidazo[1,2-b]pyridazines (5 & 7) were prepared from 3-amino-6-aryl-pyridazines (3) which in turn were obtained from the corresponding 6-aryl-pyridazine-3(2H)-ones(1) via., 6-aryl-pyridazin-3(2H)-thiones (2) as intermediates, by a reaction with an appropriate a-halocarbonyl compounds (4) or a-haloacyl carbamates (6) in a suitable solvent at reflux temperature. The resulted products were characterized by their physical, analytical and spectral data.

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45

Costas-Lago, María Carmen, Tamara Costas, Noemí Vila, and Carmen Terán. "5-[(tert-Butyldiphenylsilyloxy)methyl]pyridazin-3(2H)-one." Acta Crystallographica Section E Structure Reports Online 69, no. 12 (2013): o1826—o1827. http://dx.doi.org/10.1107/s160053681303167x.

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In the title compound, C21H24N2O2Si, a new pyridazin-3(2H)-one derivative, the carbonyl group of the heterocyclic ring and the O atom of the silyl ether are located on the same side of the pyridazinone ring and the C—C—O—Si torsion angle is −140.69 (17)°. In the crystal, molecules are linked by pairs of strong N—H...O hydrogen bonds into centrosymmetric dimers with graph-set notationR22(8). Weak C—H...π interactions are also observed.

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46

Deeb, Ali, Abdel Naby Essawy, Fathy Yasine, and Rida Fikry. "Pyridazine Derivatives and Related Compounds, Part 3 [1] Some Reactions with 4-Cyano-3(2H)-pyridazinethione." Zeitschrift für Naturforschung B 46, no. 6 (1991): 835. http://dx.doi.org/10.1515/znb-1991-0620.

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The reaction of 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide 2 with formamide, acetic anhydride and carbon disulphide yielded pyrimido[4′,5′ :4,5]thieno[2,3-c]-pyridazin-4-one derivatives. Pyrimido[4,5-c]pyridazinethione and dithione derivatives were obtained by cyclocondensation of 3-amino-5,6-diphenylpyridazine-4-carbonitrile (8) with phenyl isothiocyanate and carbon disulphide, respectively. Tetrahydropyridazino[3,4-b]-quinoline (11) was prepared by reaction of 8 with cyclohexanone in presence of zinc chloride.

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47

Gewald, K., M. Rehwald, H. M�ller, P. Bellmann, and H. Sch�fer. "Synthese neuartig substituierter Pyridazin-6(1H)-one." Monatshefte f�r Chemie Chemical Monthly 126, no. 3 (1995): 341–47. http://dx.doi.org/10.1007/bf00816103.

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48

Chung, Hyun-A., Jeum-Jong Kim, Ho-Kyun Kim, et al. "Synthesis of alkyl or aryl pyridazinyl ethers." Journal of Heterocyclic Chemistry 42, no. 4 (2005): 639–46. http://dx.doi.org/10.1002/jhet.5570420425.

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49

Balkenhohl, Moritz, Harish Jangra, Tobias Lenz, et al. "Lewis‐Säure‐dirigierte regioselektive Metallierungen an Pyridazin." Angewandte Chemie 131, no. 27 (2019): 9344–48. http://dx.doi.org/10.1002/ange.201903839.

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50

Thébault, Frédéric, Alexander J. Blake, Claire Wilson, Neil R. Champness, and Martin Schröder. "Synthesis of pyridazinyl ligands for multimetallic complexes." New J. Chem. 30, no. 10 (2006): 1498–508. http://dx.doi.org/10.1039/b611561f.

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