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Journal articles on the topic 'Pyridines, pharmacology'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2025

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1

Laxmi, Dandamudi Sri, Suryadevara V. Vardhini, Venkata R. Guttikonda, Mandava V. B. Rao, and Manojit Pal. "Synthesis of 2-substituted Furo[3,2-b]pyridines Under Pd/C-Cu Catalysis Assisted by Ultrasound: Their Evaluation as Potential Cytotoxic Agents." Anti-Cancer Agents in Medicinal Chemistry 20, no. 8 (2020): 932–40. http://dx.doi.org/10.2174/1871520620666200311102304.

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Background: Compounds containing furo[3,2-b]pyridine framework have shown interesting pharmacological properties, including anticancer activities. Though these compounds are generally synthesized via the heteroannulation processes involving acetylenic derivatives, some of them are complex. Objective: The study aimed to explore a series of 2-substituted furo[3,2-b]pyridines for their cytotoxic properties against cancer cell lines in vitro. Methods: We developed a convenient synthesis of 2-substituted furo[3,2-b]pyridines via sequential (i) C-C coupling followed by (ii) C-O bond-forming reaction

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2

Abdelrazek, Fathy M., Sobhi M. Gomha, Mohamed E. B. Shaaban, et al. "One-Pot Three-Component Synthesis and Molecular Docking of Some Novel 2-Thiazolyl Pyridines as Potent Antimicrobial Agents." Mini-Reviews in Medicinal Chemistry 19, no. 6 (2019): 527–38. http://dx.doi.org/10.2174/1389557518666181019124104.

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Background: Thiazoles and pyridines are versatile synthetic scaffolds possessing wide spectrum of biological effects including potential antimicrobial activity. Objective: In the efforts to develop suitable antimicrobia drugs, medicinal chemists have focused on thiazole derivatives. A novel series of 2-thiazolyl pyridines was prepared in a one-pot three-component reaction using 2-bromoacetyl pyridine as a starting precursor. Method: Structure of the synthesized compounds was elucidated by spectral data (FT-IR, 1H NMR, 13C NMR, and mass) and elemental analyses. The prepared compounds were scree

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3

Khalili, Faeze, Sara Akrami, Malihe Safavi, et al. "Design, Synthesis, In vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-a]Pyridines as Potent Anti-Breast Cancer Agents." Anti-Cancer Agents in Medicinal Chemistry 19, no. 2 (2019): 265–75. http://dx.doi.org/10.2174/1871520618666180903100835.

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Background: This paper reports synthesis, cytotoxic activity, and apoptosis inducing effect of a novel series of styrylimidazo[1,2-a]pyridine derivatives. Objective: In this study, anti-cancer activity of novel styrylimidazo[1,2-a]pyridines was evaluated. Methods: Styrylimidazo[1,2-a]pyridine derivatives 4a-o were synthesized through a one-pot three-component reaction of 2-aminopyridines, cinnamaldehydes, and isocyanides in high yield. All synthesized compounds 4a-o were evaluated against breast cancer cell lines including MDA-MB-231, MCF-7, and T-47D using MTT assay. Apoptosis was evaluated b

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4

Szafran, Miroslaw, and Zofia Dega-Szafran. "Complexes of Carboxylic Acids with Pyridines and Pyridine N-Oxides." HETEROCYCLES 37, no. 1 (1994): 627. http://dx.doi.org/10.3987/rev-93-sr5.

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5

Enguehard-Gueiffier, Cecile, and Alain Gueiffier. "Recent Progress in the Pharmacology of Imidazo[1,2-a]pyridines." Mini-Reviews in Medicinal Chemistry 7, no. 9 (2007): 888–99. http://dx.doi.org/10.2174/138955707781662645.

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6

Hagen, A., and V. Hagen. "Cardiotonic and vasodilator activity of some novel 3-cyano-2-oxaalkylamino-5-(4-pyridinyl)-pyridines." European Journal of Pharmacology 183, no. 3 (1990): 775. http://dx.doi.org/10.1016/0014-2999(90)92581-3.

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7

De Munno, Angela, Vincenzo Bertini, Nevio Picci, Francesca Iemma, and Marco Pocci. "Synthesis of Pluriaminated Pyridines." HETEROCYCLES 48, no. 6 (1998): 1203. http://dx.doi.org/10.3987/com-98-8144.

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8

Lila, Amr S. Abu, Marwa H. Abdallah, El-Sayed Khafagy, et al. "Design, synthesis and cytotoxic evaluation of 2-amino-4- aryl-6-substituted pyridine-3,5-dicarbonitrile derivatives." Tropical Journal of Pharmaceutical Research 20, no. 10 (2021): 2127–33. http://dx.doi.org/10.4314/tjpr.v20i10.16.

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Purpose: To synthesize novel pyridine derivatives and evaluate their efficiency as potent inhibitors of cyclin dependent kinase 2 (CDK2) enzyme for cancer therapy.Methods: Pyridine scaffold were synthesized using one-pot multicomponent condensation reaction of arylidine with different primary amines. The cytotoxic potential of the new compounds was assessed using various cell lines. Furthermore, molecular docking studies based on the crystal structure of CDK2 was carried out to determine the possible binding modes that influence the anticancer activities.Results: The results indicate that one-

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9

R. Katritzky, Alan, Jose M. Ayrrecoechea, and Luis M. Vazquez de Miguel. "Ortho-lithiation of 2-(Benzothiazol-2-ylthio)pyridine. Preparation of 2,3-Disubstituted Pyridines." HETEROCYCLES 26, no. 2 (1987): 427. http://dx.doi.org/10.3987/r-1987-02-0427.

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10

Sanapalli, Bharat Kumar Reddy, Akram Ashames, Dilep Kumar Sigalapalli, Afzal B. Shaik, Richie R. Bhandare, and Vidyasrilekha Yele. "Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review." Antibiotics 11, no. 12 (2022): 1680. http://dx.doi.org/10.3390/antibiotics11121680.

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Fused pyridines are reported to display various pharmacological activities, such as antipyretic, analgesic, antiprotozoal, antibacterial, antitumor, antifungal, anti-inflammatory, and antiapoptotic. They are widely used in the field of medicinal chemistry. Imidazopyridines (IZPs) are crucial classes of fused heterocycles that are expansively reported on in the literature. Evidence suggests that IZPs, as fused scaffolds, possess more diverse profiles than individual imidazole and pyridine moieties. Bacterial infections and antibacterial resistance are ever-growing risks in the 21st century. Onl

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11

De Munno, Angela, Vincenzo Bertini, Nevio Picci, Francesca Iemma, and Marco Pocci. "Convenient Access to 3,4,5-Trisubstituted Pyridines." HETEROCYCLES 43, no. 9 (1996): 1893. http://dx.doi.org/10.3987/com-96-7477.

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12

El-Shekeil, Ali, Abdulla Babaqi, Mohammed Hassan, and Sayed Shiba. "Facile Synthesis of Pyrazole[3,4-b]pyridines." HETEROCYCLES 27, no. 9 (1988): 2119. http://dx.doi.org/10.3987/com-88-4504.

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13

MORAN, ASUNCIÓN, ELENA MARTÍN, CRISTINA VELASCO, et al. "Antihypertensive Effect of some Oxazolo[3,2-a]pyridines, Thiazolo[3,2-a]pyridines and Pyrido[2,1-b]oxazines in Conscious Spontaneously Hypertensive Rats." Journal of Pharmacy and Pharmacology 49, no. 4 (1997): 421–25. http://dx.doi.org/10.1111/j.2042-7158.1997.tb06817.x.

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14

Bocheva, Anastasia A., Elena Yu Bibik та Sergey G. Krivokolysko. "Study of the analgesic activity of new partially hydrogenated pyridines, α-cyanothioacetamide derivatives in the pharmacological tail heat immersion test on white rats". Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ) 24, № 3 (2023): 37–43. http://dx.doi.org/10.18499/1990-472x-2023-24-3-37-43.

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Experimental study of pain helps to understand its mechanisms, features and physiological manifestations, which is essential for physiology, practical biomedicine and pharmacology. The new derivatives of di- and tetrahydropyridines synthesized in the research laboratory "Chemex" on the basis of Lugansk State University named after Vladimir Dahl were subjected to virtual bioscreening using the Swiss Target Prediction software package. Biological screening conducted in vivo, in a thermal tail immersion test on white rats, for new, partially hydrogenated pyridines, derivatives of -cyanothio

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15

Z. Alkhathlan, Hamad. "An Approach towards Fused Thieno[3,2-b]pyridines." HETEROCYCLES 45, no. 1 (1997): 45. http://dx.doi.org/10.3987/com-96-7603.

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16

Grivas, Spiros, and Malin Björk. "Synthesis of Thienoimidazo[4,5-b]pyridines and Thenylidenoimidazolinones." HETEROCYCLES 65, no. 10 (2005): 2369. http://dx.doi.org/10.3987/com-05-10486.

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17

Ochiai, Masahito, Takashi Suefuji, Motoo Shiro, and Kentaro Yamaguchi. "Complexation of Diphenyl(tetrafluoroborato)-l3-iodane with Pyridines." HETEROCYCLES 67, no. 1 (2006): 391. http://dx.doi.org/10.3987/com-05-s(t)8.

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18

Abarca-González, Belén. "The Chemistry of [1,2,3]Triazolo[1,5- a] pyridines." Journal of Enzyme Inhibition and Medicinal Chemistry 17, no. 6 (2002): 359–67. http://dx.doi.org/10.1080/1475636021000005622.

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19

De Sarro, Angela, Giovambattista De Sarro, Alba Chimirri, Silvana Grasso, Anna-Maria Monforte, and Maria Zappala. "Anticonvulsant activity of pyrrolo[1′,2′:1,2]imidazo[4,5-b]pyridines, pyrrolo[2′,1′:2,3]imidazo[4,5-c] pyridines and pyrrolo[2,1-f]purines in DBA/2 mice." General Pharmacology: The Vascular System 25, no. 5 (1994): 1027–31. http://dx.doi.org/10.1016/0306-3623(94)90114-7.

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20

Buurman, Ed T., April E. Blodgett, Kenneth G. Hull, and Daniel Carcanague. "Pyridines and Pyrimidines Mediating Activity against an Efflux-Negative Strain of Candida albicans through Putative Inhibition of Lanosterol Demethylase." Antimicrobial Agents and Chemotherapy 48, no. 1 (2004): 313–18. http://dx.doi.org/10.1128/aac.48.1.313-318.2004.

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ABSTRACT The first step in ergosterol biosynthesis in Saccharomyces cerevisiae consists of the condensation of two acetyl coenzyme A (acetyl-CoA) moieties by acetoacetyl-CoA thiolase, encoded by ERG10. The inhibition of the sterol pathway results in feedback activation of ERG10 transcription. A cell-based reporter assay, in which increased ERG10 transcription results in elevated specific β-galactosidase activity, was used to find novel inhibitors of ergosterol biosynthesis that could serve as chemical starting points for the development of novel antifungal agents. A class of pyridines and pyri

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21

CHAITANYA, G. DAVE, R. SHAH P., B. SHAH A., C. DAVE K., and J. PATEL VARSHA. "Synthesis and Biological Activity of Pyrido[3',2': 4,5)thieno[3,2-d]pyrimidines." Journal of Indian Chemical Society Vol. 66, JAN 1989 (1989): 48–50. https://doi.org/10.5281/zenodo.5948607.

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Department of Chemistry, St. Xavier's College, Navrangpura, Ahmedabad-380 009 <strong>D</strong>epartment of Pharmacology, N. H. L. Municipal Medical College, Ahmedabad-880 007 <em>Manuscript received I4 July 1988, revised 29 September 1988, accepted 4 October 1988</em> 2-Carbetboxy-3-aminothieno [2,3-b]pyridines (1) were reacted with isothiocyanates to obtain 2-thioxo-3-substituted-7, 9-diphenylpyrido[3<em>'</em>, 2<em>'</em> : 4,5]thieno[3, 2-d]pyrimidin-4 (3H)-ones (3) which on methylation afforded 2-methyimerrapro-3-sabstitated-7,9-diphenylpyrido[3<em>'</em>2<em>&

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22

Bisagni, Emile, Marilys Rautureau, and Christiane Huel. "Synthesis of 3-Aryl-4-acetyl-1H-pyrazolo[3,4-b]pyridines and 3-Aryl-4-acetyl-1H-pyrazolo[4,3-c]pyridines." HETEROCYCLES 29, no. 9 (1989): 1815. http://dx.doi.org/10.3987/com-89-5060.

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23

El-Gendy, M., H. Farag, A. Abmed, J. Stedman, and G. Alkaramany. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES." Bulletin of Pharmaceutical Sciences. Assiut 15, no. 1 (1992): 9–21. http://dx.doi.org/10.21608/bfsa.1992.70208.

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24

Pace, Christopher M., Joseph R. Donnelly, Jeffrey L. Jeter, William C. Brumley, and G. Wayne Sovocool. "Determination of Aromatic Amines in Soils." Journal of AOAC INTERNATIONAL 79, no. 3 (1996): 777–83. http://dx.doi.org/10.1093/jaoac/79.3.777.

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Abstract A rapid liquid chromatographic (LC) method with ultraviolet (UV) or fluorescence detection was developed for parts-per-billion levels of aromatic amines in soils. 2,4-Diaminotoluene, pyridine, aniline, 2-pi-coline, 2-toluidine, 5-nitro-2-toluidine, 2-methyl-6-ethylaniline, 4-aminobiphenyl, 4-nitroaniline, 1-naphthyl-amine, 2-methoxyaniline, and 2-naphthyiamine were tested. The method involves extraction by sonication with 1% ammonium hydroxide–acetonitrile and analysis by LC using gradient elution with aqueous 0.01 M ammonium acetate–0.0005% triethylamine and acetonitrile. Recoveries

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25

Allen Whitney, Ralph, and John M. Boyle. "Nucleophilic Addition of Dilithiated Amides to 3-Substituted Pyridines." HETEROCYCLES 23, no. 1 (1985): 57. http://dx.doi.org/10.3987/r-1985-01-0057.

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26

Shiao, Min-Jen, Li-Hua Shih, Win-Long Chia, and Tay-Yuan Chau. "A Convenient Synthesis of Five-membered Heteroaryl-substituted Pyridines." HETEROCYCLES 32, no. 11 (1991): 2111. http://dx.doi.org/10.3987/com-99-5785.

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27

Hibino, Satoshi, Kenichi Harada, Tominari Choshi, Eiichi Sugino, and Koichi Sato. "A Convenient Route to the Imidazo[4,5-b]pyridines." HETEROCYCLES 42, no. 1 (1996): 213. http://dx.doi.org/10.3987/com-94-s6-1.

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28

Guillaumet, Gérald, Marie-Claude Viaud, Patricia Jamoneau, and Laurence Savelon. "Synthesis of 6-Substituted 2-Phenyloxazolo[4,5-b]pyridines." HETEROCYCLES 41, no. 12 (1995): 2799. http://dx.doi.org/10.3987/com-95-7245.

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29

Langer, Peter, Uwe Albrecht, Anja Preuss, Andreas Schmidt, and Christine Fischer. "Regioselective Synthesis of 2,4-(Dioxobutyl)dihydroquinolines and -pyridines by Chloroformiate-Mediated Reaction of 1,3-Bis(Silyl Enol Ethers) with Quinolines and Pyridines." HETEROCYCLES 80, no. 1 (2010): 289. http://dx.doi.org/10.3987/com-09-s(s)12.

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30

Yan, Hong-Xia, Chun-Fang Xu, Hong Yang, et al. "Network Pharmacology-Based Analysis on the Curative Effect of Kunxian Capsules against Rheumatoid Arthritis." Evidence-Based Complementary and Alternative Medicine 2021 (September 29, 2021): 1–11. http://dx.doi.org/10.1155/2021/6812374.

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Kunxian capsules (KCs), a Chinese patent medicine, have been clinically proven to be effective in the treatment of rheumatoid arthritis (RA). However, the chemical profile of KC remains to be characterized, and the mechanism underlying the protective effect against RA is yet to be elucidated. Here, a network pharmacology-based approach was adopted, integrated with the chemical profiling of KC by UHPLC-Q-TOF/MS. As a result, a total of 67 compounds have been identified from KC extract, among which 43 were authenticated by comparison to the mass spectrum of standard chemicals. ADME behaviors of

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31

Glozman, O. M., L. N. Borisova, V. I. Kuz'min, et al. "Synthesis and pharmacological activity of 3-(3-amino-2-oxypropoxy)pyridines." Pharmaceutical Chemistry Journal 23, no. 1 (1989): 33–37. http://dx.doi.org/10.1007/bf00758311.

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32

Takahashi, Masahiko, Toshiaki Orihara, Takanori Sasaki, Tetsuya Yamatera, Ken'ichi Yamazaki, and Atomi Yoshida. "Synthesis of 2H-Pyrazolo[3,4-b]pyridines from 1,1,2,2-Tetracyanocyclopropanes." HETEROCYCLES 24, no. 10 (1986): 2857. http://dx.doi.org/10.3987/r-1986-10-2857.

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33

Tanji, Ken-ichi, Takehiko Sasahara, Junko Suzuki, and Takeo Higashino. "Pyrazolopyridines. 1. Formylation and Acylation of Pyrazolo[1,5-a]pyridines." HETEROCYCLES 35, no. 2 (1993): 915. http://dx.doi.org/10.3987/com-92-s(t)85.

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34

Wang, Jian-Wu, Xu-Tang Tao, Jiong Jia, and Yan-Qing Ge. "Facile Synthesis of Imidazo[1,2-a]pyridines via Tandem Reaction." HETEROCYCLES 81, no. 1 (2010): 185. http://dx.doi.org/10.3987/com-09-11856.

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35

Sirakanyan, S. N., É. K. Akopyan, R. G. Paronikyan, I. M. Nazaryan, A. G. Akopyan, and A. A. Ovakimyan. "Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines." Pharmaceutical Chemistry Journal 53, no. 6 (2019): 495–99. http://dx.doi.org/10.1007/s11094-019-02026-8.

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36

Dabaeva, V. V., M. R. Bagdasaryan, Sh Sh Dashyan, et al. "Synthesis and Neurotropic Activity of New Condensed Pyrano[4,3-b]-Pyridines Derivatives." Pharmaceutical Chemistry Journal 52, no. 10 (2019): 844–49. http://dx.doi.org/10.1007/s11094-019-1912-z.

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37

Garapati, Sushma, Babi Lakkoju, Vandana Vemulapalli, and Gowri Sankar Redipalli. "Recent synthetic and biological aspects of 1, 4-dihydro pyridine derivatives." Research Journal of Chemistry and Environment 27`, no. 10 (2023): 137–44. http://dx.doi.org/10.25303/2710rjce1370144.

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Among the large variety of organic compounds, heterocycles are interesting compounds widely occurring in nature, showing biological activities. Dihydropyridine (DHP) is a privileged scaffold having nitrogen in a six-membered cyclic ring as a central moiety. DHP is a significant compound studied in medicinal chemistry and pharmacology activities. Therefore, organic chemists have made considerable efforts to create new drug candidates with DHP subunits associated with a known or possible pharmacophore. The Hantzsch is a well-studied synthesis of DHP and pyridines and is currently one of the reli

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38

A. Abramovitch, Rudolph, and Wang You-Xiong. "Regiospecific Amination of 3-Substituted Pyridines Using Imidoyl Chloride Functionalized Polystyrene." HETEROCYCLES 26, no. 8 (1987): 2065. http://dx.doi.org/10.3987/r-1987-08-2065.

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39

A. Ciufolini, Marco, and Bryan K. Chan. "Methodology for the Synthesis of Pyridines and Pyridones: Development and Applications." HETEROCYCLES 74, no. 1 (2007): 101. http://dx.doi.org/10.3987/rev-07-sr(w)4.

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40

Hassner, Alfred, and Eliezer Falb. "Introducing a Methyl Group into Pyridines and Quinolines: A Mini-Review." HETEROCYCLES 99, no. 2 (2019): 766. http://dx.doi.org/10.3987/rev-18-sr(f)6.

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41

Sliwa, Henri, Muriel Doise, and Dominique Blondeau. "Syntheses of 3,8-Dihydroxyimidazo[1,2-a]pyridines and [1,2-a]pyrazines." HETEROCYCLES 34, no. 11 (1992): 2065. http://dx.doi.org/10.3987/com-92-6013.

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42

Miki, Yasuyoshi, Sanae Yagi, Hiroko Hachiken, and Masazumi Ikeda. "Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridines by Electrophilic Reactions." HETEROCYCLES 38, no. 8 (1994): 1881. http://dx.doi.org/10.3987/com-94-6757.

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43

Bourguignon, Jean-Jacques, Jean-Luc Moutou, Martine Schmitt, and Valérie Collot. "A Novel Method of Preparation of 3-Acylimidazo[1,2-a]pyridines." HETEROCYCLES 45, no. 5 (1997): 897. http://dx.doi.org/10.3987/com-96-7696.

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44

Teulade, Jean-Claude, Emmanuel Moreau, Jean-Michel Chezal, et al. "Efficient Synthesis of New Polyfunctionalized Thiadiazaacenaphthylenes from Imidazo[1,2-a]pyridines." HETEROCYCLES 57, no. 1 (2002): 21. http://dx.doi.org/10.3987/com-01-9347.

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45

Toyota, Masahiro, and Shunya Mikami. "Palladium Acetate-Catalyzed One-Pot Synthesis of Mono- and Disubstitued Pyridines." HETEROCYCLES 99, no. 2 (2019): 1315. http://dx.doi.org/10.3987/com-18-s(f)45.

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46

Slama, James T., Julie L. Hancock, Taikyun Rho, Lidia Sambucetti, and Kenneth A. Bachmann. "Influence of Some Novel N-Substituted Azoles and Pyridines on Rat Hepatic CYP3A Activity." Biochemical Pharmacology 55, no. 11 (1998): 1881–92. http://dx.doi.org/10.1016/s0006-2952(98)00096-3.

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47

Kumar, Sanjay, Sajal Kumar Das, Sumanta Dey, et al. "Antiplasmodial Activity of [(Aryl)arylsulfanylmethyl]Pyridine." Antimicrobial Agents and Chemotherapy 52, no. 2 (2007): 705–15. http://dx.doi.org/10.1128/aac.00898-07.

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ABSTRACT A series of [(aryl)arylsufanylmethyl]pyridines (AASMP) have been synthesized. These compounds inhibited hemozoin formation, formed complexes (KD = 12 to 20 μM) with free heme (ferriprotoporphyrin IX) at a pH close to the pH of the parasite food vacuole, and exhibited antimalarial activity in vitro. The inhibition of hemozoin formation may develop oxidative stress in Plasmodium falciparum due to the accumulation of free heme. Interestingly, AASMP developed oxidative stress in the parasite, as evident from the decreased level of glutathione and increased formation of lipid peroxide, H2O

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48

Mataka, Shuntaro, Hideki Gorohmaru, Thies Thiemann, Tsuyoshi Sawada, Kazufumi Takahashi, and Akiyoshi Tori-i. "10-Hydroxy-7-arylindeno[1,2-b]-1,2,5-oxadiazolo[3,4-d]pyridines and 7-Aryl-10-oxoindeno[1,2-b]-1,2,5-oxadiazolo[3,4-d]pyridines— Synthesis, Spectra, and Polymorphism." HETEROCYCLES 50, no. 2 (1999): 895. http://dx.doi.org/10.3987/com-98-s(h)88.

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49

Kobayashi, Kazuhiro, Seiki Fujita, Shuhei Fukamachi, and Hisatoshi Konishi. "Synthesis of 1-Aryl-1H-pyrrolo[2,3-b]pyridines (1-Aryl-7-azaindoles) by a Thermal Dehydration-Cyclization-Dehydrogenation Sequence of 2-Arylamino-3-(1-hydroxyalkyl)pyridines." HETEROCYCLES 75, no. 11 (2008): 2735. http://dx.doi.org/10.3987/com-08-11441.

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50

Ibata, Toshikazu, and Sergei V. Chapyshev. "Synthesis of Highly Substituted Pyridines through Nucleophilic Substitution of Tetrachloro-3-cyanopyridine." HETEROCYCLES 36, no. 10 (1993): 2185. http://dx.doi.org/10.3987/com-93-6387.

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