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Journal articles on the topic 'Pyrimidine systems'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Mohammed, F. K., and M. G. Badrey. "Synthesis of Pyrimidines and Heteroannulated Pyrimidine Ring Systems." Journal of the Korean Chemical Society 55, no. 2 (2011): 218–29. http://dx.doi.org/10.5012/jkcs.2011.55.2.218.

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2

Sirakanyan, Spinelli, Geronikaki, et al. "Synthesis, Antitumor Activity, and Docking Analysis of New Pyrido[3’,2’:4,5]furo(thieno)[3,2-d]pyrimidin-8-amines." Molecules 24, no. 21 (2019): 3952. http://dx.doi.org/10.3390/molecules24213952.

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Continuing our research in the field of new heterocyclic compounds, herein we report on the synthesis and antitumor activity of new amino derivatives of pyrido[3’,2’:4,5](furo)thieno[3,2-d]pyrimidines as well as of two new heterocyclic systems: furo[2–e]imidazo[1,2-c]pyrimidine and furo[2,3-e]pyrimido[1,2-c]pyrimidine. Thus, by refluxing the 8-chloro derivatives of pyrido[3’,2’:4,5]thieno(furo)[3,2-d]pyrimidines with various amines, the relevant pyrido[3’,2’:4,5]thieno(furo)[3,2-d]pyrimidin-8-amines were obtained. Further, the cyclization of some amines under the action of phosphorus oxychlori

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3

Monier, Mohamed, Doaa Abdel-Latif, Ahmed El-Mekabaty, Başak D. Mert, and Khaled M. Elattar. "Advances in the Chemistry of 6-6 Bicyclic Systems: Chemistry of Pyrido[3,4- d]pyrimidines." Current Organic Synthesis 16, no. 6 (2019): 812–54. http://dx.doi.org/10.2174/1570179416666190704113647.

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The aim of this work is to discuss the chemistry of pyrido[3,4-d]pyrimidines as one of the most important heterocyclic compounds with remarkable synthetic, biological and medical applications. In this overview, the chemistry of heterocyclic compounds incorporated the pyrido[3,4-d]pyrimidine scaffold as demonstrated by chemical reactions and different preparation processes. The anticipated compounds were synthesized from pyridine or pyrimidine compounds and a description of the reactivity of substituents attached to ring carbon and nitrogen atoms is discussed. On the other hand, the synthesis a

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4

Dabrowski, R., J. Baran, B. Sosnowska, and J. Przedmojski. "Binary Smectic Systems Including Trinuclear Pyrimidines with and without Nematic Gap." Zeitschrift für Naturforschung A 42, no. 1 (1987): 35–42. http://dx.doi.org/10.1515/zna-1987-0107.

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Phase diagrams of binary mixtures are presented in which one component has been selected from among four trinuclear isomeric pyrimidines forming a nematic or smectic A, phase, and the second one from cyanocompounds forming an Ad smectic phase. Depending on the molecular structure of pyrimidine, mixtures were obtained that show or show not a nematic gap between the A1 and Ad smectic regions. In the latter case it was found that the relation TSA → N= f(x) has two independent branches in different ranges of the concentration x. The measured spacing of the smectic layers in such mixtures points to

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5

Maitry, Jyoti, Suman Uraiha, Lata Patel Choudhary, and Yogesh Pounikar. "Focused Insights Into Emerging Pyrimidine Molecules with Multifarious Anti-Infective Perspectives." International Journal of Medical & Pharmaceutical Sciences 13, no. 11 (2023): 06–13. http://dx.doi.org/10.31782/ijmps.2023.131102.

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Over the past 60 years, pyrimidines have grown in importance as a fundamental structural component of many therapeutic compounds. This article reviews the recent anti-infective (antibacterial, antifungal, and antiviral) activities where pyrimidines have played a significant role in drug discovery. In addition to presenting the medicinal agents’ synthesis, the essay emphasizes the significance of the biological target in relation to the illness model. Furthermore covered are the pharmacokinetics and pharmacodynamics, biological potency, and ADME characteristics. This survey aims to illustrate t

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6

Abdel-Hafez, Shams H., Ragaa A. Ahmed, Mohamed A. Abdel-Azim, and Khairy M. Hassan. "Selenium containing Heterocycles: Part 1. Synthesis of Some New Substituted Pyrido[3′,2′:4,5]selenolo[3,2-d]pyrimidines and Related Fused Tetracyclic Systems." Journal of Chemical Research 2007, no. 10 (2007): 580–84. http://dx.doi.org/10.3184/030823407x25506.

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New series of selenolo[2,3- b]pyridine, pyrido[3′,2′:4,5]selenolo[3,2- d]pyrimidine, 7,8-dihydro-2,4-dimethylpyrrolo [1,2- a]pyrido[3′,2′:4,5]selenolo[3,2- d]pyrimidin-10(6 H)-one and 7,9-dimethylpyrido[3′,2′:4,5]selenolo[3,2- d][1,2,4] triazolo[4,3- c]pyrimidine derivatives were synthesised from 3-cyano-4,6-dimethylpyridine-2(1 H)-selenone (1). Spectroscopic (IR, 1H, MS) of the newly synthesised compounds are reported.

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7

Nammalwar, Baskar, and Richard A. Bunce. "Recent Advances in Pyrimidine-Based Drugs." Pharmaceuticals 17, no. 1 (2024): 104. http://dx.doi.org/10.3390/ph17010104.

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Pyrimidines have become an increasingly important core structure in many drug molecules over the past 60 years. This article surveys recent areas in which pyrimidines have had a major impact in drug discovery therapeutics, including anti-infectives, anticancer, immunology, immuno-oncology, neurological disorders, chronic pain, and diabetes mellitus. The article presents the synthesis of the medicinal agents and highlights the role of the biological target with respect to the disease model. Additionally, the biological potency, ADME properties and pharmacokinetics/pharmacodynamics (if available

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8

Maji, Pradip Kumar. "Synthesis of Pyrimidine-Annulated Five-Membered Heterocycles: An Overview." Current Organic Chemistry 23, no. 20 (2019): 2204–69. http://dx.doi.org/10.2174/1385272823666191019111627.

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This review describes the non-exhaustive scenery of the synthesis of various biologically interesting pyrimidine annulated five-membered heterocyclic ring systems that have been appeared in the literature during the last two decades. During this period, different synthetic routes and various methodologies have been developed for the functionalization of pyrimidine ring towards the construction of five-membered heterocyclic rings. The aim of this review is to give an overview of the assorted methodologies that have been reported about the chemistry of construction of pyrimidines annulated nitro

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9

Dabaeva, V. V., E. G. Paronikyan, I. M. Barkhudaryants, Sh Sh Dashyan, and M. R. Baghdasaryana. "Synthesis and Transformations of Hydrazine-Substituted Pyrano[3″,4″:5′,6′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine." Журнал общей химии 94, no. 3 (2024): 370–75. http://dx.doi.org/10.31857/s0044460x24030079.

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A method was developed for the synthesis of 11-(2-furyl)-4-hydrazino-8,8-dimethyl-7,10-dihydro-8H-pyrano[3″,4″:5′,6′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine on the basis of which new heterocyclic systems were synthesized. The conditions for the azido/tetrazole transformation of the resulting condensed tetrazolo[1,5-c]pyrimidine were studied. Isomeric triazolo[4,3-c]- and -[1,5-c]pyrimidines were synthesized and the conditions for the transformation of the first isomer into the second in accordance with the Dimroth rearrangement were established.

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10

Mahmoud, M. R., A. A. Shalaby, T. A. Gad, and A. A. El-Khamry. "A facile synthesis and heteroannulation of pyrido[2,3-d]pyrimidine and related heterocyclic systems." Journal of Chemical Research 2009, no. 10 (2009): 612–15. http://dx.doi.org/10.3184/030823409x12523324765777.

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7-Amino-1,2,3,4-tetrahydro-4-oxo-2-thioxo-5-(3,4,5-trimethoxyphenyl)pyrido[2,3- d]pyrimidine (1) was prepared and reacted with methyl iodide and ethyl chloroacetate to give the S-alkylated products 2 and 3, respectively. The reaction of 1 or 3 with hydrazine hydrate yielded the same 2-hydrazino derivative 4. Treatment of 4 with 2,4-pentanedione, 2-acetylcyclohexanone and ethyl acetoacetate afforded the corresponding pyrazolylpyrido[2,3- d]pyrimidine derivatives (5–7), while phthalic anhydride gave the phthalazinyl compound 8. Ethoxymethylenemalononitrile with the hydrazine 4 formed the fused 1

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11

Ramírez-Gamboa, Diana, Ana Laura Díaz-Zamorano, Edgar Ricardo Meléndez-Sánchez, et al. "Photolyase Production and Current Applications: A Review." Molecules 27, no. 18 (2022): 5998. http://dx.doi.org/10.3390/molecules27185998.

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The photolyase family consists of flavoproteins with enzyme activity able to repair ultraviolet light radiation damage by photoreactivation. DNA damage by the formation of a cyclobutane pyrimidine dimer (CPD) and a pyrimidine-pyrimidone (6-4) photoproduct can lead to multiple affections such as cellular apoptosis and mutagenesis that can evolve into skin cancer. The development of integrated applications to prevent the negative effects of prolonged sunlight exposure, usually during outdoor activities, is imperative. This study presents the functions, characteristics, and types of photolyases,

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12

Aly, Aly A. "A Facile Synthesis and Heteroannulation of Thiazolopyrimidine and Related Heterocyclic Systems." Journal of Chemical Research 2007, no. 9 (2007): 552–56. http://dx.doi.org/10.3184/030823407x248621.

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Reaction of pyrimidinylacetic acid 2 with different electrophilic and nucleophilic reagents gave annulated pyrimidine derivatives 3–11, respectively. Compound 3 ([7-(dibenzothien-2-yl)-5-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]-pyrimidin-6-yl]acetic acid) was transformed to pyrimidinylacetyl azide 12, which upon heterocyclisation with active methylene compounds, acidic and basic reagents furnished functionally substituted heteroaromatic compounds 13–21, respectively. The structures of the synthesised derivatives were elucidated by elemental and spectral analyses.

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13

Dodonova, Jelena, and Sigitas Tumkevicius. "Fused Pyrrolo[2,3-d]pyrimidines (7-Deazapurines) by Palladium-Catalyzed Direct N–H and C–H Arylation Reactions." Synthesis 49, no. 11 (2017): 2523–34. http://dx.doi.org/10.1055/s-0036-1588734.

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Palladium-catalyzed intramolecular direct C–H arylations for the synthesis of hitherto unknown fused hetero systems containing an incorporated pyrrolo[2,3-d]pyrimidine scaffold are described. Pyrimido[5′,4′:4,5]pyrrolo[2,1-a]isoindoles were synthesized from 2,4-diarylpyrrolo[2,3-d]pyrimidines and o-bromobenzyl bromides by using a cascade N-benzylation/C–H arylation reaction sequence. A series of pyrimido[5′,4′:4,5]pyrrolo[1,2-f]phenanthridines were successfully assembled via a domino process involving the palladium-catalyzed direct double C–H arylation reactions of 2,4,7-triarylpyrrolo[2,3-d]

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14

Volatier, Thomas, Björn Schumacher, Berbang Meshko, Karina Hadrian, Claus Cursiefen, and Maria Notara. "Short-Term UVB Irradiation Leads to Persistent DNA Damage in Limbal Epithelial Stem Cells, Partially Reversed by DNA Repairing Enzymes." Biology 12, no. 2 (2023): 265. http://dx.doi.org/10.3390/biology12020265.

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The cornea is frequently exposed to ultraviolet (UV) radiation and absorbs a portion of this radiation. UVB in particular is absorbed by the cornea and will principally damage the topmost layer of the cornea, the epithelium. Epidemiological research shows that the UV damage of DNA is a contributing factor to corneal diseases such as pterygium. There are two main DNA photolesions of UV: cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6–4) photoproducts (6-4PPs). Both involve the abnormal linking of adjacent pyrimide bases. In particular, CPD lesions, which account for the vast m

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15

Batista, Daniela, Stefan Schwarz, Anne Loesche, et al. "Synthesis of glucopyranos-6′-yl purine and pyrimidine isonucleosides as potential cholinesterase inhibitors. Access to pyrimidine-linked pseudodisaccharides through Mitsunobu reaction." Pure and Applied Chemistry 88, no. 4 (2016): 363–79. http://dx.doi.org/10.1515/pac-2016-0102.

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AbstractThe synthesis of new isonucleosides comprising purine and pyrimidine-derived systems linked to methyl glucopyranosidyl units at C-6 and evaluation of their cholinesterase inhibitory profiles is reported. Their access was based on the Mitsunobu coupling of partially acetylated and benzylated methyl glucopyranosides with purine and pyrimidine derivatives. While the reactions with purines and theobromine proceeded with complete regioselectivity, affording exclusively N9- or N1-linked 6′-isonucleosides, respectively, the use of pyrimidine nucleobases led to N1 and/or N3-glucopyranosid-6′-y

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16

Sayed, Hayam, Hebat-Allah Abbas, Eman Morsi, Abd Amr, and Nayera Abdelwahad. "Antimicrobial activity of some synthesized glucopyranosyl-pyrimidine carbonitrile and fused pyrimidine systems." Acta Pharmaceutica 60, no. 4 (2010): 479–91. http://dx.doi.org/10.2478/v10007-010-0033-8.

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Antimicrobial activity of some synthesized glucopyranosyl-pyrimidine carbonitrile and fused pyrimidine systems 3-Amino-5-(4-chlorophenylamino)-4-cyanofuran-2-carboxamide (2) was used as the key molecule for preparation of various furopyrimidines 3-9 and formation of spiro-cycloalkane furopyrimidines 10, 11. Also, poly fused heterocyclic compounds 13-17 were prepared from compound 2. The synthesized compounds were screened for their antimicrobial activity.

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17

Maji, Pradip Kumar. "Recent Progress in the Synthesis of Pyrimidine Heterocycles: A Review." Current Organic Chemistry 24, no. 10 (2020): 1055–96. http://dx.doi.org/10.2174/1385272824999200507123843.

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Pyrimidine heterocycles are proven to be biologically active heterocycles, found in many biological systems, displaying a broad spectrum of biological activities including anticancer, anxiolytic, antioxidant, antiviral, antifungal, anticonvulsant, antidepressant and antibacterial activities. Recently, various synthetic approaches, synthetic strategy, the variation of substrates and study devoted towards the evaluation of biological activities for the pyrimidine heterocycles have been reported in the literature. This review article describes the synthesis of various biologically interesting pyr

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18

Monier, Mohamed, Doaa Abdel-Latif, Ahmed El-Mekabaty, and Khaled M. Elattar. "Bicyclic 6 + 6 Systems: Advances in the Chemistry of Heterocyclic Compounds Incorporated Pyrimido[1,2-a]Pyrimidine Skeleton." Mini-Reviews in Organic Chemistry 17, no. 6 (2020): 717–39. http://dx.doi.org/10.2174/1389557519666190925161145.

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The present review has highlighted the chemistry of pyrimido[1,2-a]pyrimidine compounds as one of the most important classes of heterocyclic systems. The main sections include: (1) The synthesis of pyrimido[1,2-a]pyrimidines, (2) reactivity of the substituents attached to the carbon and nitrogen atoms of the ring and (3) biological applications. A discussion demonstrated that the proposed mechanisms of unexpected synthetic routes were intended. The purpose of this review is to provide an overview of the chemistry of pyrimido[1,2-a]pyrimidines to date, in which the compounds should be widely ap

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19

Dyachenko, I. V., R. I. Vas’kevich, A. I. Vas’kevich, V. V. Polovinko, and M. V. Vovk. "Fused Pyrimidine Systems: XVII. Imidazo- and Pyrimidopyrido[3,2-d]pyrimidin-4(3H)-ones." Russian Journal of Organic Chemistry 54, no. 3 (2018): 436–43. http://dx.doi.org/10.1134/s1070428018030119.

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20

Farghaly, Ahmed M., Ola H. Rizk, Inas Darwish, et al. "Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers." Molecules 27, no. 7 (2022): 2240. http://dx.doi.org/10.3390/molecules27072240.

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Some new pyrimidine derivatives comprising arylsulfonylhydrazino, ethoxycarbonylhydrazino, thiocarbamoylhydrazino and substituted hydrazone and thiosemicarbazide functionalities were prepared from Biginelli-derived pyrimidine precursors. Heterocyclic ring systems such as pyrazole, pyrazolidinedione, thiazoline and thiazolidinone ring systems were also incorporated into the designed pyrimidine core. Furthermore, fused triazolopyrimidine and pyrimidotriazine ring systems were prepared. The synthesized compounds were evaluated for their calcium channel blocking activity as potential hypotensive a

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21

Stasevych, Maryna, Svitlana Sabat, Rostyslav Musyanovych, and Volodymyr Novikov. "Synthesis of condensed S-, N- containing heterocyclic systems on the base of 2-amino-4,9-dioxo-4,9-dihydronaphto[2,3-b]thiophene-3-ethylcarboxilate." Chemistry & Chemical Technology 2, no. 3 (2008): 157–62. http://dx.doi.org/10.23939/chcht02.03.157.

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Synthesis of a new 2-aryl-4Н-naphtho[2’,3’,4,5]thieno[2,3-d][1,3]oxazine-4,5,10-triones, 2-arylnaphtho[2’,3’,4,5]thieno[2,3-d][1,3]pyrimidine-4,5,10(3Н)-triones, 3-phenyl naphtho[2’,3’,4,5]thieno[2,3-d][1,3]pyrimidine-2,4,5,10(1Н, 3Н)-tetraone and 2-thioxo-2,3-dyhydronaphth[2’,3’,4,5]thieno[2,3-d]pyrimidine-4,5,10(1Н)-trione was carried out. The mechanism of 2-aryl-4Н-naphtho[2’,3’,4,5]thieno[2,3-d][1,3]oxazine-4,5,10-triones formation was suggested.

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22

Ahmed, Essam K., Johannes Fröhlich, and Fritz Sauter. "Fusion Reactions of N-Heterocyclic Moieties to Thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidines." Collection of Czechoslovak Chemical Communications 61, no. 1 (1996): 147–54. http://dx.doi.org/10.1135/cccc19960147.

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Derivatives of the novel heterocyclic parent systems imidazolo[1,2-a]thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidine (B) and thiopyrano[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine (C) have been synthesized by fusing pyrimidine moieties to 2-amino-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid ethyl ester (1) and -3-carbonitrile (10), followed by cyclization reactions of the title intermediates A thus obtained.

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23

Kato, Ryo, Tomoji Maeda, Toshihiro Akaike, and Ikumi Tamai. "Characterization of novel Na+-dependent nucleobase transport systems at the blood-testis barrier." American Journal of Physiology-Endocrinology and Metabolism 290, no. 5 (2006): E968—E975. http://dx.doi.org/10.1152/ajpendo.00160.2005.

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In the testis, nucleosides and nucleobases are important substrates of the salvage pathway for nucleotide biosynthesis, and one of the roles of Sertoli cells is to provide nutrients and metabolic precursors to spermatogenic cells located within the blood-testis barrier (BTB). We have already shown that concentrative and equilibrative nucleoside transporters are expressed and are functional in primary-cultured rat Sertoli cells as a BTB model, but little is known about nucleobase transport at the BTB or about the genes encoding specific nucleobase transporters in mammalian cells. In the present

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24

El-Rayyes, N. R., and H. M. Ramadan. "Heterocycles. PartX. Synthesis of new pyrimidine systems." Journal of Heterocyclic Chemistry 24, no. 3 (1987): 589–96. http://dx.doi.org/10.1002/jhet.5570240310.

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25

Hinteregger, Clemens, Johanna Dolensky, Werner Seebacher, et al. "Synthesis and Antiprotozoal Activity of Azabicyclo-Nonane Pyrimidine Hybrids." Molecules 28, no. 1 (2022): 307. http://dx.doi.org/10.3390/molecules28010307.

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2,4-Diaminopyrimidines and (dialkylamino)azabicyclo-nonanes possess activity against protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against pathogens of malaria tropica and sleeping sickness. The activities and selectivities of compounds strongly depended on the substitution pattern of both ring systems as well as on the position of the nitrogen atom in the bicycles. The most promising hybrids of 3-azabicyclo-nonane with 2-aminopyrimidine showed activity against P. falciparum NF54 in submicromolar concentration and high selectivity. A hybrid with pyrrolidin

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26

Elattar, Khaled M., Başak Doğru Mert, M. Monier, and Ahmed El-Mekabaty. "Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds." RSC Advances 10, no. 26 (2020): 15461–92. http://dx.doi.org/10.1039/d0ra00411a.

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The current study provides an overview of the synthetic routes, reactivity and privileged biological characteristics of bicyclic heterocycles incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine cores.

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27

Lipunova, Galina N., Emiliya V. Nosova, Valery N. Charushin, and Oleg N. Chupakhin. "Functionalized Quinazolines and Pyrimidines for Optoelectronic Materials." Current Organic Synthesis 15, no. 6 (2018): 793–814. http://dx.doi.org/10.2174/1570179415666180622123434.

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Background: Quinazolines, the important group of benzodiazines, are widely known in medicinal chemistry due to their broad spectrum of biological activities. Notably, extensive research on the synthesis and application of quinazoline derivatives for electronic devices, luminescent elements, photoelectric conversion elements, and image sensors has been published recently. Objective: This review reports luminescent small molecules and chelate compounds including a quinazoline or pyrimidine ring in their scaffold highlighting their applications related to photo- and electroluminescence. Conclusio

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28

Hloušková, Nikola, Michal Rouchal, Marek Nečas, and Robert Vícha. "2,6-Dichloro-7-isopropyl-7H-purine." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1585. http://dx.doi.org/10.1107/s160053681201879x.

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In the title molecule, C8H8Cl2N4, the essentially planar imidazole and pyrimidine rings [maximum deviations of 0.0030 (15) and 0.0111 (15) Å, respectively] make a dihedral angle of 1.32 (8)°. In the crystal, the fused-ring systems are stacked approximately parallel to the bc plane, with a centroid–centroid distance between inversion-related pyrimidine rings of 3.5189 (9) Å.

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29

Tumkevicius, Sigitas, та Jelena Dodonova. "Pyrrolo[2,3-d]pyrimidine-Core-Extended π-Systems: Synthesis of 2,4,7-Triarylpyrrolo[2,3-d]pyrimidines". Synlett 2011, № 12 (2011): 1705–8. http://dx.doi.org/10.1055/s-0030-1260931.

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30

Ho, Jonathan Z, Kyle R Van Arsdale, and Matthew P Braun. "Efficient Synthesis of14C-Labeled 1H-Pyrazolo[3,4-d]pyrimidine and Related [4.3.0]-Bicyclic Pyrimidino Systems." Helvetica Chimica Acta 91, no. 5 (2008): 958–63. http://dx.doi.org/10.1002/hlca.200890102.

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31

Babu, B. Ramesh, D. V. Ramana, and S. R. Ramadas. "Synthesis of Condensed Thiazolo-[3,2-a]pyrimidine Systems." Sulfur reports 11, no. 1 (1991): 143–62. http://dx.doi.org/10.1080/01961779108048764.

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32

Suhasini, Kilaru Padma, Jayanthi Suresh Kumar, Voosala Christopher, and Challa Gangu Naidu. "Synthesis, Characterization of New Benzopyran Pyrimidines and Study of their Solvatochromic Behaviour." Asian Journal of Chemistry 36, no. 4 (2024): 913–18. http://dx.doi.org/10.14233/ajchem.2024.30980.

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Five new benzopyran pyrimidines (5a-e) were synthesized in three steps by using silica-sulphuric acid as catalyst. All the synthesized benzopyran pyrimidines with various substituents were characterized by spectroscopic techniques such as 1H NMR, 13C NMR, IR and mass spectroscopy. The structural features of these molecules containing pyrimidine ring with π-conjugated systems and various functional groups on the aromatic rings greatly influence their photophysical properties. Thus, they behave as better candidates for developing the photoelectric materials. Thus, it is proposed to synthesize, c

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33

Elgemeie, Galal H., Ali M. Salah, Reham A. Mohamed, and Peter G. Jones. "Crystal structure of (E)-2-amino-4-methylsulfanyl-6-oxo-1-{[(thiophen-2-yl)methylidene]amino}-1,6-dihydropyrimidine-5-carbonitrile." Acta Crystallographica Section E Crystallographic Communications 71, no. 11 (2015): 1319–21. http://dx.doi.org/10.1107/s205698901501885x.

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The title compound, C11H9N5OS2, a 1-thiophen-2-ylmethyleneaminopyrimidine derivative, displays an essentially planar C—NH2group. The conformation across the N=C bond linking the pyrimidine and thienyl groups isE. The pyrimidine and thienyl ring systems subtend an inter-planar angle of 42.72 (5)°. In the crystal, molecules are linked by N–H...Nnitrileand N–H...O=C hydrogen bonds, forming chains parallel to thebaxis.

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Trilleras, Jorge, Alfredo Pérez-Gamboa, and Jairo Quiroga. "SNAr Reactions on 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde." Molbank 2022, no. 3 (2022): M1426. http://dx.doi.org/10.3390/m1426.

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We report the experimental results of unexpected aromatic nucleophilic substitution reaction products on 2-amino-4,6-dichloropyrimidine-5-carbaldehyde. The isolated compounds are products of amination, solvolysis, and condensation processes under mild and environmentally friendly conditions, due to the influence of structural factors of the starting pyrimidine and a high concentration of alkoxide ions. This method allows the building of pyrimidine-based compound precursors of N-heterocyclic systems.

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Kim, Heejun, Ala Jo, Jaeyoung Ha, Youngjun Lee, Yoon Soo Hwang, and Seung Bum Park. "A pyrazolo[1,5-a]pyridine-fused pyrimidine based novel fluorophore and its bioapplication to probing lipid droplets." Chemical Communications 52, no. 50 (2016): 7822–25. http://dx.doi.org/10.1039/c6cc02184k.

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Abele, Edgars, and Ramona Abele. "Oximes of Nucleosides and Related Compounds: Synthesis, Reactions and Biological Activity." Current Organic Synthesis 15, no. 5 (2018): 650–65. http://dx.doi.org/10.2174/1570179415666180524112811.

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Background: Literature data on the synthesis and structure of oximes of nucleosides and related nitrogenous bases from pyrimidine and purine were reviewed. Synthesis of novel heterocyclic systems from nucleoside oximes related pyrimidine oximes was described. The biological activity of derivatives of nucleoside and nitrogenous base oximes was also reviewed. <p> Objective: The review focuses on the recent progress in the area of nucleoside oxime synthesis, reactions and biological activity. Conclusion: In summary, literature data on the synthesis and structure of oximes of nucleosides and

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Elattar, Khaled M., and Başak Doğru Mert. "Recent developments in the chemistry of bicyclic 6-6 systems: chemistry of pyrido[4,3-d]pyrimidines." RSC Advances 6, no. 76 (2016): 71827–51. http://dx.doi.org/10.1039/c6ra12364c.

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V. A, Tsygankova, Voloshchuk I.V, Andrusevich Ya.V., et al. "Pyrimidine Derivatives As Analogues Of Plant Hormones For Intensification Of Wheat Growth During The Vegetation Period." JOURNAL OF ADVANCES IN BIOLOGY 15 (June 21, 2022): 1–10. http://dx.doi.org/10.24297/jab.v15i.9237.

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Wheat is one of the economically important cereals that are widely used in the agricultural sector of many countries. A very important issue is the development of new effective growth regulators to improve the growth and development of this crop in order to increase its productivity. In our investigations the regulating activity of the synthetic low molecular weight heterocyclic compounds, pyrimidine derivatives on growth and development of wheat (Triticum aestivum L.) variety Tyra was studied. It was found that the use of pyrimidine derivatives in a concentration of 10-7M in water solution re

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Raghunath, Saundane Anand, Yarlakatti Manjunatha, and Kalpana Rayappa. "Synthesis, antimicrobial, and antioxidant activities of some new indole analogues containing pyrimidine and fused pyrimidine systems." Medicinal Chemistry Research 21, no. 11 (2011): 3809–17. http://dx.doi.org/10.1007/s00044-011-9915-7.

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Moustafa, Moustafa Sherif, Ahmed Moukhtar Nour-Eldeen, Saleh Mohamed Al-Mousawi, Afaf Abd El-Hameed, Michael Magdy, and Kamal Usef Sadek. "Regioselectivity in the reaction of 5-amino-3-anilino-1H-pyrazole-4-carbonitrile with cinnamonitriles and enaminones: Synthesis of functionally substituted pyrazolo[1,5-a]pyrimidine derivatives." Green Processing and Synthesis 11, no. 1 (2022): 116–28. http://dx.doi.org/10.1515/gps-2022-0009.

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Abstract The development of efficient methods for the synthesis of polyfunctional N-heterocycles is an important area of research in organic and medicinal chemistry. Pyrazolo[1,5-a]pyrimidine derivatives are purine analogous of biomedical importance and have been extremely studied for their broad spectrum of biological activities. Recently, they have attracted great interest in materials science owing to their photophysical properties. 3(5)-Aminopyrazoles are extensively utilized in the synthesis of condensed heterocyclic systems, particularly pyrazolo[1,5-a]pyrimidines via the reaction with 1

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Sedenkova, Kseniya N., Julia V. Kolodyazhnaya, Dmitry A. Vasilenko та ін. "Novel π-conjugated systems based on pyrimidine N-Oxide". Dyes and Pigments 164 (травень 2019): 72–81. http://dx.doi.org/10.1016/j.dyepig.2018.12.067.

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Kim, Sang-Tae, and Seth D. Rose. "Pyrimidine dimer splitting in covalently linked dimer—arylamine systems." Journal of Photochemistry and Photobiology B: Biology 12, no. 2 (1992): 179–91. http://dx.doi.org/10.1016/1011-1344(92)85007-h.

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Dyachenko, I. V., R. I. Vas’kevich, and M. V. Vovk. "Fused pyrimidine systems: XIII. Synthesis and some transformations of 1,3-thiazolo(thiazino)-fused pyrido[3,4-d]pyrimidines." Russian Journal of Organic Chemistry 50, no. 2 (2014): 263–70. http://dx.doi.org/10.1134/s1070428014020201.

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Tumkevicius, Sigitas, та Jelena Dodonova. "ChemInform Abstract: Pyrrolo[2,3-d]pyrimidine-Core-Extended π-Systems: Synthesis of 2,4,7-Triarylpyrrolo[2,3-d]pyrimidines." ChemInform 42, № 51 (2011): no. http://dx.doi.org/10.1002/chin.201151156.

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Aljohani, Ahmed K. B., Sanadelaslam S. A. El-Hddad, Marwa Alsulaimany, et al. "Design, nanogel synthesis, anti-proliferative activity and in silico ADMET profile of pyrazoles and pyrimidines as topo-II inhibitors and DNA intercalators." RSC Advances 15, no. 13 (2025): 10037–48. https://doi.org/10.1039/d5ra00166h.

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Elinson, Michail N., Anatoly N. Vereshchagin, Yuliya E. Ryzhkova, Fedor V. Ryzhkov, Artem N. Fakhrutdinov, and Mikhail P. Egorov. "Efficient Electrocatalytic Approach to Spiro[Furo[3,2-b]pyran-2,5′-pyrimidine] Scaffold as Inhibitor of Aldose Reductase." Electrochem 2, no. 2 (2021): 295–310. http://dx.doi.org/10.3390/electrochem2020021.

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A continuously growing interest in convenient and ‘green’ reaction techniques encourages organic chemists to elaborate on new synthetic methodologies. Nowadays, organic electrochemistry is a new useful method with important synthetic and ecological advantages. The employment of an electrocatalytic methodology in cascade reactions is very promising because it provides the combination of the synthetic virtues of the cascade strategy with the ecological benefits and convenience of electrocatalytic procedures. In this research, a new type of the electrocatalytic cascade transformation was found: t

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Holman, Michelle A., Natalie M. Williamson, and A. David Ward. "Preparation and Cyclization of Some N-(2,2-Dimethylpropargyl) Homo- and Heteroaromatic Amines and the Synthesis of Some Pyrido[2,3-d]pyrimidines." Australian Journal of Chemistry 58, no. 5 (2005): 368. http://dx.doi.org/10.1071/ch04260.

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The Cu(i) catalyzed cyclization of o-substituted N-(2,2-dimethylpropargyl)anilines yields 8-substituted 2,2-dimethyl-1,2-dihydroquinolines, while m-substituted analogues provide a mixture of 5- and 7-substituted dihydroquinoline systems. This reaction can be extended to 2-amino-N-(2,2-dimethylpropargyl)anthracene, yielding a dihydronaphtho[2,3-f]quinoline product, and to aminoquinoline derivatives, which yield substituted phenanthroline products. Pyridine analogues did not cyclize, apparently because of complexation with the copper reagent. An alternative synthetic approach to these cyclized p

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Gabdrakhmanov, D. R., D. A. Samarkina, F. G. Valeeva, et al. "Supramolecular systems based on dicationic pyrimidine-containing surfactants and polyethyleneimine." Russian Chemical Bulletin 64, no. 3 (2015): 573–78. http://dx.doi.org/10.1007/s11172-015-0902-x.

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BABU, B. R., D. V. RAMANA, and S. R. RAMADAS. "ChemInform Abstract: Synthesis of Condensed Thiazolo(3,2-a)pyrimidine Systems." ChemInform 23, no. 23 (2010): no. http://dx.doi.org/10.1002/chin.199223308.

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Gayakhe, Vijay, Yogesh S. Sanghvi, Ian J. S. Fairlamb, and Anant R. Kapdi. "Catalytic C–H bond functionalisation of purine and pyrimidine nucleosides: a synthetic and mechanistic perspective." Chemical Communications 51, no. 60 (2015): 11944–60. http://dx.doi.org/10.1039/c5cc03416g.

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C–H bond functionalisation of heteroarenes, especially nucleosides, has received a lot of attention in the past few years. This review describes the state-of the art in this area with a global aspiration for possibly functionalising purine and pyrimidine moieties in complex biomolecular systems.

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