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Journal articles on the topic 'Pyrrole-hydrazide'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Torosyan, S. A., Z. F. Nuriakhmetova, F. A. Gimalova, and M. S. Miftakhov. "Synthesis of new 1,3,4-oxadiazole and 1,2,3-triazole derivatives based on thieno[3,2-<i>b</i>]pyrrolecarboxylic acid." Журнал органической химии 59, no. 2 (2023): 266–70. http://dx.doi.org/10.31857/s0514749223020143.

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Starting from 4-benzylthieno[3,2- b ]pyrrole-5-carboxylic acid hydrazide and 4-(2-propyn-1-yl)thieno[3,2- b ]pyrrole-5-carboxylic acid methyl ester new 1,3,4-oxadiazole and 1,2,4-triazole derivatives were obtained.

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2

Mateev, Emilio, and Maya Georgieva. "Biological evaluation, molecular docking and DFT calculations of pyrrole-based derivatives as dual acting AChE/MAO-B inhibitors." Pharmacia 70, no. 4 (2023): 1019–26. http://dx.doi.org/10.3897/pharmacia.70.e113014.

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Considering the complex pathophysiology of Alzheimer’s disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, six pyrrole-based compounds were evaluated for their dual monoamine oxidase type B (MAO-B) and acetylcholinesterase (AChE) inhibitory capacities. Most of the compounds revealed good AChE activities at 10 µM concentrations. 5d most potently inhibited AChE with 75%, while the hydrazide 5 demonstrated blocking effect of 51% at 10 µM concentrations. However, li

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3

Mateev, Emilio, and Maya Georgieva. "Biological evaluation, molecular docking and DFT calculations of pyrrole-based derivatives as dual acting AChE/MAO-B inhibitors." Pharmacia 70, no. (4) (2023): 1019–26. https://doi.org/10.3897/pharmacia.70.e113014.

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Considering the complex pathophysiology of Alzheimer's disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, six pyrrole-based compounds were evaluated for their dual monoamine oxidase type B (MAO-B) and acetylcholinesterase (AChE) inhibitory capacities. Most of the compounds revealed good AChE activities at 10 µM concentrations. 5d most potently inhibited AChE with 75%, while the hydrazide 5 demonstrated blocking effect of 51% at 10 µM concentrations. However, li

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4

Mateev, Emilio, Muhammed Tilahun Muhammed, Ali Irfan, Shubham Sharma, Maya Georgieva, and Alexander Zlatkov. "Hydrazide-hydrazones as novel antioxidants - in vitro, molecular docking and DFT studies." Pharmacia 71 (October 16, 2024): 1–8. http://dx.doi.org/10.3897/pharmacia.71.e133114.

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The pathogenesis of many diseases, such as obesity, depression, cancer, cataract, and neurodegenerative diseases, is related to the generation of reactive oxygen species (ROS). Structures possessing radical-scavenging properties act as antioxidants and they could prevent the progression of the aforementioned diseases. Therefore, the current work was focused on the resynthesis and the antioxidant evaluation of 13 hydrazide-hydrazones. Two in vitro tests - DPPH and ABTS, were applied for the determination of the antioxidant capacities. The free-radical scavenging assays displayed that the hydraz

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5

Mateev, Emilio, Muhammed Muhammed Tilahun, Ali Irfan, Shubham Sharma, Maya Georgieva, and Alexander Zlatkov. "Hydrazide-hydrazones as novel antioxidants - in vitro, molecular docking and DFT studies." Pharmacia 71 (October 16, 2024): 1–8. https://doi.org/10.3897/pharmacia.71.e133114.

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The pathogenesis of many diseases, such as obesity, depression, cancer, cataract, and neurodegenerative diseases, is related to the generation of reactive oxygen species (ROS). Structures possessing radical-scavenging properties act as antioxidants and they could prevent the progression of the aforementioned diseases. Therefore, the current work was focused on the resynthesis and the antioxidant evaluation of 13 hydrazide-hydrazones. Two <i>in vitro</i> tests - DPPH and ABTS, were applied for the determination of the antioxidant capacities. The free-radical scavenging assays displayed that the

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6

Mateev, Emilio, Valentin Karatchobanov, Marjano Dedja, et al. "Novel Pyrrole Derivatives as Multi-Target Agents for the Treatment of Alzheimer’s Disease: Microwave-Assisted Synthesis, In Silico Studies and Biological Evaluation." Pharmaceuticals 17, no. 9 (2024): 1171. http://dx.doi.org/10.3390/ph17091171.

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Considering the complex pathogenesis of Alzheimer’s disease (AD), the multi-target ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, one novel pyrrole-based hydrazide (vh0) and four corresponding hydrazide–hydrazones (vh1-4) were synthesized by applying highly efficient MW-assisted synthetic protocols. The synthetic pathway provided excellent yields and reduced reaction times under microwave conditions compared to conventional heating. The biological assays indicated that most of the novel

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7

Mateev, Emilio, Ali Irfan, Alexandrina Mateeva, Magdalena Kondeva-Burdina, Maya Georgieva, and Alexander Zlatkov. "In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors." Pharmacia 71 (February 5, 2024): 1–7. http://dx.doi.org/10.3897/pharmacia.71.e114120.

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Virtual screening is emerging as a highly applied technique and gained prominence as widely used method for the search and identification of potential hits, significantly reducing the time needed to discover novel and effective compounds compared to high-throughput screening. Recently, the superiority of simulations with multiple programs compared to a single software docking has been discussed. The aim of this work was to apply consensus docking, molecular mechanics/generalized Born surface area (MM/GBSA) free binding energy recalculations, and in vitro evaluations on an in-house dataset of r

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8

Mateev, Emilio, Ali Irfan, Alexandrina Mateeva, Magdalena Kondeva-Burdina, Maya Georgieva, and Alexander Zlatkov. "In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors." Pharmacia 71, no. () (2024): 1–7. https://doi.org/10.3897/pharmacia.71.e114120.

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Virtual screening is emerging as a highly applied technique and gained prominence as widely used method for the search and identification of potential hits, significantly reducing the time needed to discover novel and effective compounds compared to high-throughput screening. Recently, the superiority of simulations with multiple programs compared to a single software docking has been discussed. The aim of this work was to apply consensus docking, molecular mechanics/generalized Born surface area (MM/GBSA) free binding energy recalculations, and <i>in vitro</i> evaluations on an in-house datas

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9

Tzankova, Diana, Lily Peikova, Stanislava Vladimirova, and Maya Georgieva. "Development and validation of RP-HPLC method for stability evaluation of model hydrazone, containing a pyrrole ring." Pharmacia 66, no. (3) (2019): 127–34. https://doi.org/10.3897/pharmacia.66.e47035.

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RP-HPLC method with UV detection was developed and validated for determination of the chemical stability and stability in close to physiological conditions of a model pyrrole hydrazone ethyl 5-(4-bromophenyl)-1-(1-(2-(4-hydroxy-3-methoxybenzylidene) hydrazineyl)-4-methyl-1-oxopentan-2-yl)-2-methyl-1H-pyrrole-3-carboxylate (D_5d), containing susceptible to hydrolysis hydrazone group. The evaluated substance was subjected to the influence of a variety of pH , representing the main physiological values of 37°C and corresponding pH values in the stomach (pH 2.0), blood (pH 7.4) and small intestine

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10

Vladimirova, Stanislava, Rossitsa Hristova, and Ivan Iliev. "Synthesis, Cytotoxicity and Antiproliferative Effect of New Pyrrole Hydrazones." Molecules 29, no. 23 (2024): 5499. http://dx.doi.org/10.3390/molecules29235499.

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Novel pyrrole-based carbohydrazide (1) and hydrazones (1A–D) were synthesized, characterized, and subjected to spectroscopic studies. The hydrazones were obtained by reacting a pyrrole hydrazide with substituted pyrrole aldehydes. The initial carbohydrazide was prepared by selective hydrazinolysis of the obtained N-pyrrolylcarboxylic acid ethyl ester. The biological activity of the newly synthesized compounds was investigated in vitro on a panel of tumor and non-tumor cell lines. Mouse embryonic fibroblasts BALB 3T3 clone A31 were used in the safety test (BALB 3T3 NRU-assay). Antiproliferative

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11

Tzankova, Diana, Lily Peikova, and Maya Georgieva. "PRELIMINARY DETERMINATION OF HYDROLYTIC STABILITY OF A PYRROLE-BASED HYDRAZIDE AND ITS HYDRAZONE." CBU International Conference Proceedings 6 (September 25, 2018): 1192–98. http://dx.doi.org/10.12955/cbup.v6.1314.

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A validated UV/VIS method for preliminary determination of the chemical stability and stability in close to physiological conditions of a model pyrrole hydrazide and its corresponding derivative, bearing susceptible to hydrolysis hydrazone group was developed. The evaluated substances were subjected to the influence of a variety of pH medias, representing the main physiological values of 37°C and corresponding pH values in the stomach (pH 2.0), blood (pH 7.4) and small intestine (pH 9.0). The chemical stability at strong alkali media of pH 13.0 was also evaluated. The hydrazide was found to be

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12

Tzankova, Diana, Lily Peikova, Stanislava Vladimirova, and Maya Georgieva. "Development and validation of RP-HPLC method for stability evaluation of model hydrazone, containing a pyrrole ring." Pharmacia 66, no. 3 (2019): 127–34. http://dx.doi.org/10.3897/pharmacia.66.e47035.

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RP-HPLC method with UV detection was developed and validated for determination of the chemical stability and stability in close to physiological conditions of a model pyrrole hydrazone ethyl 5-(4-bromophenyl)-1-(1-(2-(4-hydroxy-3-methoxybenzylidene) hydrazineyl)-4-methyl-1-oxopentan-2-yl)-2-methyl-1H-pyrrole-3-carboxylate (D_5d), containing susceptible to hydrolysis hydrazone group. The evaluated substance was subjected to the influence of a variety of pH , representing the main physiological values of 37°C and corresponding pH values in the stomach (pH 2.0), blood (pH 7.4) and small intestine

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13

Tzankova, Diana, Hristina Kuteva, Emilio Mateev, et al. "Synthesis, DFT Study, and In Vitro Evaluation of Antioxidant Properties and Cytotoxic and Cytoprotective Effects of New Hydrazones on SH-SY5Y Neuroblastoma Cell Lines." Pharmaceuticals 16, no. 9 (2023): 1198. http://dx.doi.org/10.3390/ph16091198.

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A series of ten new hydrazide–hydrazone derivatives bearing a pyrrole ring were synthesized and structurally elucidated through appropriate spectral characteristics. The target hydrazones were assessed for radical scavenging activity through 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) tests, with ethyl 5-(4-bromophenyl)-1-(2-(2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazine-yl)-2-oxoethyl)-2-methyl-1H-pyrrole-3-carboxylate (7d) and ethyl 5-(4-bromophenyl)-1-(3-(2-(4-hydroxy-3,5-dimethoxybenzylidene) hydra zine-yl)-3-oxopropyl)-2-methyl

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14

Mateeva, Alexandrina, Magdalena Kondeva-Burdina, Lily Peikova, and Maya Georgieva. "Optimization and validation of RP-HPLC method for evaluation of pyrrole -containing hydrazones in isolated rat synaptosomes." Pharmacia 70, no. 4 (2023): 1015–18. http://dx.doi.org/10.3897/pharmacia.70.e113039.

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In the current study, RP-HPLC method for evaluation of 2 pyrrol-based hydrazones in isolated rat synaptosomes was optimized and validated according to ICH guidelines. The synaptosomes were obtained by multiple centrifugations with Percoll reagent and the selected 2 N-pyrollyl hydrazide-hydrazones were incubated for 2 hours at 37 °C. Subsequently, the purified fraction through protein precipitation was analyzed by an UltiMateDionex 3000 DAD system with Purospher STAR C18 (4.6 x 12.5 cm, 5 µm) column. The mobile phase, consisting of acetonitrile: phosphate buffer pH 3.5: methanol in ratio 42/36/

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15

Mateeva, Alexandrina, Magdalena Kondeva-Burdina, Lily Peikova, and Maya Georgieva. "Optimization and validation of RP-HPLC method for evaluation of pyrrole -containing hydrazones in isolated rat synaptosomes." Pharmacia 70, no. (4) (2023): 1015–18. https://doi.org/10.3897/pharmacia.70.e113039.

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In the current study, RP-HPLC method for evaluation of 2 pyrrol-based hydrazones in isolated rat synaptosomes was optimized and validated according to ICH guidelines. The synaptosomes were obtained by multiple centrifugations with Percoll reagent and the selected 2 N-pyrollyl hydrazide-hydrazones were incubated for 2 hours at 37 °C. Subsequently, the purified fraction through protein precipitation was analyzed by an UltiMateDionex 3000 DAD system with Purospher STAR C18 (4.6 x 12.5 cm, 5 µm) column. The mobile phase, consisting of acetonitrile: phosphate buffer pH 3.5: methanol in ratio 42/36/

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16

Attanasi, Orazio A., Paolino Filippone, Francesca R. Perrulli, and Stefania Santeusanio. "Regioselective role of the hydrazide moiety in the formation of complex pyrrole–pyrazole systems." Tetrahedron 57, no. 7 (2001): 1387–94. http://dx.doi.org/10.1016/s0040-4020(00)01125-x.

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17

Antonyová, Veronika, Ameneh Tatar, Tereza Brogyányi, et al. "Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators." International Journal of Molecular Sciences 23, no. 18 (2022): 10850. http://dx.doi.org/10.3390/ijms231810850.

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Targeting of epigenetic mechanisms, such as the hydroxymethylation of DNA, has been intensively studied, with respect to the treatment of many serious pathologies, including oncological disorders. Recent studies demonstrated that promising therapeutic strategies could potentially be based on the inhibition of the TET1 protein (ten-eleven translocation methylcytosine dioxygenase 1) by specific iron chelators. Therefore, in the present work, we prepared a series of pyrrolopyrrole derivatives with hydrazide (1) or hydrazone (2–6) iron-binding groups. As a result, we determined that the basic pyrr

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18

Akdağ, Kadriye, Fatih Tok, Sevgi Karakuş, Ömer Erdoğan, Özge Çevik, and Bedia Kaymakçıoğlu. "Synthesis and Biological Evaluation of Some Hydrazide-Hydrazone Derivatives as Anticancer Agents." Acta Chimica Slovenica 69, no. 4 (2022): 863–75. http://dx.doi.org/10.17344/acsi.2022.7614.

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In this study, a series of hydrazide-hydrazone derivatives (3a-3u) were synthesized and evaluated for their anticancer activitiesagainst prostate cancer cell line (PC-3), breast cancer cell line (MCF-7), colon cancer cell line (HT-29) and human umbilical vein endothelial cells (HUVEC) using MTT assay. In particular, compound 3h having a pyrrole ring was found to be the most potent derivative with IC50 = 1.32, 2.99, 1.71 μM against PC-3, MCF-7, HT-29 cancer cell lines respectively using paclitaxel as a standard compound. Furthermore, compound 3h was subjected to further biological studies such

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19

Refat, Hala M., and A. A. Fadda. "Synthesis and antimicrobial activity of some novel hydrazide, benzochromenone, dihydropyridine, pyrrole, thiazole and thiophene derivatives." European Journal of Medicinal Chemistry 70 (December 2013): 419–26. http://dx.doi.org/10.1016/j.ejmech.2013.09.003.

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20

Kondeva-Burdina, Magdalena, Emilio Mateev, Borislav Angelov, Virginia Tzankova, and Maya Georgieva. "In Silico Evaluation and In Vitro Determination of Neuroprotective and MAO-B Inhibitory Effects of Pyrrole-Based Hydrazones: A Therapeutic Approach to Parkinson’s Disease." Molecules 27, no. 23 (2022): 8485. http://dx.doi.org/10.3390/molecules27238485.

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Parkinson’s disease is a huge burden in modern medicinal practice. A serious drawback of current antiparkinsonian therapy is its symptomatic nature. This directed our investigations in the search for new more potent derivatives, affecting not only the loss of dopaminergic neurons but also the oxidative damage of neuronal cells. Thus in vitro neurotoxicity and neuroprotective analysis on a group of N-pyrrolyl hydrazide–hydrazones were performed. The neurotoxicity of the target derivatives was determined on a subcellular level in isolated rat synaptosomes, mitochondria and microsomes determining

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21

Attanasi, Orazio A., Paolino Filippone, Francesca R. Perrulli, and Stefania Santeusanio. "ChemInform Abstract: Regioselective Role of the Hydrazide Moiety in the Formation of Complex Pyrrole-Pyrazole Systems." ChemInform 32, no. 24 (2010): no. http://dx.doi.org/10.1002/chin.200124124.

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Refat, Hala M., and A. A. Fadda. "ChemInform Abstract: Synthesis and Antimicrobial Activity of Some Novel Hydrazide, Benzochromenone, Dihydropyridine, Pyrrole, Thiazole and Thiophene Derivatives." ChemInform 45, no. 20 (2014): no. http://dx.doi.org/10.1002/chin.201420137.

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23

Saidov, N. B., V. A. Georgiyants, and N. V. Garnaya. "Synthesis of new potential biological active substances among 3-mercapto-4-amino-5-benzyl-1,2,4-triazol-4H derivatives." Farmatsevtychnyi zhurnal, no. 3 (September 4, 2018): 52–57. http://dx.doi.org/10.32352/0367-3057.3.15.01.

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Conventional approaches to the formation of 1,2,4-triazole ring allow to introduce different substituents into the heterocyclic ring during the synthesis of key intermediates stage. In continuation of previous studies the synthesis of 3-mercapto-4-amino-5-benzyl-1,2,4-triazole-4H derivatives is described. The aim of investigation was synthesis of a series of new derivatives of 3-mercapto-4-amino-5-benzyl-1,2,4-triazole, proving their structure by physico-chemical methods and planning of pharmacological screening using PASS. Phenylacetic acid ethyl ester has been used for the synthe

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24

Sadiq, Zainab Majid, and Ahlam Marouf Al-Azzawi. "Design, synthesis and antimicrobial activity screening of new dimethyl maleimidyl heterocyclic derivatives based on 4-(N-dimethyl maleimidyl) phenyl hydrazide." Edelweiss Applied Science and Technology 9, no. 5 (2025): 120–35. https://doi.org/10.55214/25768484.v9i5.6806.

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The research involved the design and synthesis of a collection of innovative dimethyl maleimide heterocyclic derivatives through a multistep synthesis process. The synthesis of compound [1] ethyl-4-(N-dimethyl maleimidyl) benzoate was achieved through the reaction of dimethyl maleic anhydride with ethyl-4-amino benzoate. In the second stage, molecule [1] was reacted with hydrazine hydrate to provide compound [2] 4-(N-dimethyl maleimidyl)phenyl hydrazide. Compound [2] is the crucial precursor from which all objectives compounds were produced. In the third step, compound [2] was subjected to a c

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25

Bhatt, Keyur D., Disha J. Vyas, Bharat A. Makwana, Savan M. Darjee, and Vinod K. Jain. "Highly stable water dispersible calix[4]pyrrole octa-hydrazide protected gold nanoparticles as colorimetric and fluorometric chemosensors for selective signaling of Co(II) ions." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 121 (March 2014): 94–100. http://dx.doi.org/10.1016/j.saa.2013.10.076.

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26

Artico, Marino, Romano Silvestri, Augusto Pifferi, Gabriella De Martino, Silvio Massa, and Carmela Saturnino. "Reductive Smiles Rearrangement of 1-[(5-Chloro-2-nitrophenyl)- sulfonyl]-1H-pyrrole-2-carbo-hydrazide to 1-Amino-6-chloro-2- (1H-pyrrol-2-yl)benzimidazole." HETEROCYCLES 53, no. 10 (2000): 2163. http://dx.doi.org/10.3987/com-00-8970.

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27

Joshi, S. D., H. M. Vagdevi, V. P. Vaidya, and G. S. Gadaginamath. "Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: A novel class of potential antibacterial and antitubercular agents." European Journal of Medicinal Chemistry 43, no. 9 (2008): 1989–96. http://dx.doi.org/10.1016/j.ejmech.2007.11.016.

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28

Joshi, S. D., Yogesh More, H. M. Vagdevi, V. P. Vaidya, G. S. Gadaginamath, and V. H. Kulkarni. "Synthesis of new 4-(2,5-dimethylpyrrol-1-yl)/4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial, antifungal and antitubercular agents." Medicinal Chemistry Research 22, no. 3 (2012): 1073–89. http://dx.doi.org/10.1007/s00044-012-0112-0.

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29

Ishida, Masatoshi, Kensuke Nakahara, Ryuichi Sakashita, et al. "N-confused phlorin: a stable dihydroporphyrin isomer containing a confused pyrrole ring." Journal of Porphyrins and Phthalocyanines 18, no. 10n11 (2014): 909–18. http://dx.doi.org/10.1142/s1088424614500692.

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Synthesis of bona fide N -confused phlorin derivatives through simple chemical reduction of N -confused porphyrin precursors using sodium borohydride, p-toluenesulfonyl hydrazide, etc. is described. Spectroscopic, X-ray diffraction analyses and DFT-assisted calculations of these species support the nonaromatic phlorin electronic structure.

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Mansuri, Rubeena, Raj Badekar, and Priyanka Jhalora. "Synthesis, Characterization and Biological Evaluation of Novel Methoxy Benzaldehyde Substituted Derivatives of Pyrazolopyrimidine-4-hydrazide." Asian Journal of Chemistry 35, no. 8 (2023): 1921–26. http://dx.doi.org/10.14233/ajchem.2023.27908.

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Several novel pyrrolopyrimidine derivatives of methoxybenzaldehydes with biologically active pyrrole moieties were synthesized to investigate their antibacterial, antifungal and cytotoxic activities. Elemental analysis, UV-spectra, FT-IR, 1H NMR and 13C NMR spectra, were used to characterize the synthesized compounds. The in vitro antifungal and antibacterial activities were tested for all the synthesized compounds. Compared to the reference drugs e.g. fluconazole and streptomycin, most of the compounds tested positive for antifungal and antibacterial activity. All tested compounds demonstrate

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Zlatanova-Tenisheva, Hristina, and Stanislava Vladimirova. "Pharmacological Evaluation of Novel Hydrazide and Hydrazone Derivatives: Anti-Inflammatory and Analgesic Potential in Preclinical Models." Molecules 30, no. 7 (2025): 1472. https://doi.org/10.3390/molecules30071472.

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Hydrazones, characterized by their C=N–NH functional group, are promising candidates in medicinal chemistry due to their ability to interact with biological targets. This study evaluated the anti-inflammatory and analgesic properties of N-pyrrolylcarbohydrazide (1) and four pyrrole hydrazone derivatives (1A–D) in male Wistar rats (6 weeks old). Anti-inflammatory activity was assessed using a carrageenan-induced paw edema model, while formalin, tail flick, and paw withdrawal tests evaluated analgesia. Compound 1 exhibited dose-dependent anti-inflammatory activity. At 20 mg/kg, significant edema

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32

Oh, Hyunjin, and Ikyon Kim. "Catalyst-Free Assembly of Poly-Functionalized 1,2,4-Triazole-Fused N-Heterocycle, 6-Acylated Pyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine." Organic & Biomolecular Chemistry, 2023. http://dx.doi.org/10.1039/d3ob01747h.

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A catalyst-free synthetic route to a new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[3,4-c]pyrazine, was realized upon sequential exposure of pyrrole-2-carbonitrile-derived substrate to DMF-DMA and acyl hydrazide through which acylated pyrazine and 1,2,4-triazole...

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"Cytotoxicity Profile of Calix[4]pyrrole Derivatives on HeLa and MCF-7 Human Cancer Cell Lines via In vitro Study and Molecular Modelling." Biointerface Research in Applied Chemistry 12, no. 5 (2021): 6991–7000. http://dx.doi.org/10.33263/briac125.69917000.

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Amongst significant macromolecules, the cytotoxic activity of calixarene analogs is significant due to their unique biomedical properties. Recently, calix[4]pyrrole have shown remarkable efficacy and have extended new dimensions towards different biomedical and therapeutic applications. Herein, meso-tetra (methyl) meso-tetra (3-methoxy 4-hydroxy phenyl) calix[4]pyrrole (HMCP) have been studied for their remarkable cytotoxic activity against HeLa and human breast adenocarcinoma (MCF-7) cancer cell lines in comparison to its hydrazide derivative, meso-tetra (methyl) meso-tetra (3-methoxy 4-hydro

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"Coupling Reactions by Highly Efficient Octacalix[4] Pyrrole Wrapped Scrupulous Nano-Palladium Catalyst." Biointerface Research in Applied Chemistry 11, no. 1 (2020): 7632–45. http://dx.doi.org/10.33263/briac111.76327645.

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Work is focused on OHCP-PdNPs synthesis with the help of meso-modified OHCP derivatives. OHCP-PdNPs utilized for the C-C coupling reactions as an efficient nanocatalyst. This study includes the stability as well as pH studies of fine PdNps. OHCP is an electron-rich ligand that is capable of reducing as well as encapsulate the metal ions because of the availability of electron-rich hydrazide functional group and H-bonding promoter four pyrrole units. In comparison with normal hydrazine, CP-hydrazide has a higher withdrawal ability, so Pd-NPs periphery is surrounded by them and undergoes stronge

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35

Mateev, Emilio, Maya Georgieva, and Alexander Zlatkov. "Design, microwave-assisted synthesis, biological evaluation, molecular docking and ADME studies of pyrrole-based hydrazide-hydrazones as potential antioxidant agents." Macedonian Journal of Chemistry and Chemical Engineering 41, no. 2 (2022). http://dx.doi.org/10.20450/mjcce.2022.2494.

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In this study, one novel N-pyrrolyl carboxylic acid (3), the corresponding N-pyrrolyl hydrazide (5), and four new hydrazide-hydrazones (5a-d) bearing electron donating moieties were designed, synthesized, and fully elucidated by 1H NMR, FT-IR, and HRMS. The hydrazide-hydrazones were produced in five steps, which were optimized by applying microwave heating. The microwave-assisted synthesis significantly decreased the reaction times and increased the yields of the title molecules. In addition, all novel compounds were assessed for their radical scavenging properties by employing DPPH and ABTS a

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Nuriakhmetova, Z. F., S. A. Torosyan, Z. A. Sultangulova, E. M. Minnibaeva, and F. A. Gimalova. "NEW DERIVATIVES OF THE HYDRAZIDE 4-BENZYL-4H-THIENO[3,2-b]PYRROLE-5-CARBOXYLIC ACID." Вестник Башкирского университета, 2022, 958. http://dx.doi.org/10.33184/bulletin-bsu-2022.4.24.

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Veronika, Antonyová, Tatar Ameneh, Brogyányi Tereza, et al. "Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators." September 16, 2022. https://doi.org/10.3390/ijms231810850.

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Targeting of epigenetic mechanisms, such as the hydroxymethylation of DNA, has been intensively studied, with respect to the treatment of many serious pathologies, including oncological disorders. Recent studies demonstrated that promising therapeutic strategies could potentially be based on the inhibition of the TET1 protein (ten-eleven translocation methylcytosine dioxygenase 1) by specific iron chelators. Therefore, in the present work, we prepared a series of pyrrolopyrrole derivatives with hydrazide (<strong>1</strong>) or hydrazone (<strong>2</strong>–<strong>6</strong>) iron-bindi

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Vidya, Kamatar Prashanth K. U. Channabasappa S. Hallikeri* Shrinivas D. Joshi. ""SYNTHESIS AND CHARACTERIZATION OF NEW PYRROLYL OXADIAZOLE AS ANTIMICROBIAL AGENTS"." March 21, 2023. https://doi.org/10.5281/zenodo.7755038.

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The various novel nitrogen containing heterocyclic compounds were synthesized and are screened for antibacterial and antitubercular activities, purity of newly synthesized compounds confirmed by using TLC and structures for the same compounds were confirmed by using IR, NMR, <sup>13</sup>C and Mass spectrum. Pyrrole ring was constructed by reacting benzocaine with 2, 5-dimethoxytetrahydrofuran in presence of glacial acetic acid to obtain ethyl 4-pyrrol-1-ylbenzoate (2) in good yield. Conversion of ethyl 4-pyrrol-1-ylbenzoate (2) into 4-pyrrol-1-yl-benzoic acid hydrazide (3), which was achieved

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Sandhya, Chinnamulagund Ashwini S. Joshi Chetana Sravanthi Avunoori V. H. Kulkarni Shrinivas D. Joshi*. "SYNTHESIS AND ANTITUBERCULAR EVALUATION OF CERTAIN PYRROLE DERIVATIVES." March 21, 2023. https://doi.org/10.5281/zenodo.7755252.

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A series of 2-aryl-5-[4-(1<em>H-</em>pyrrol-1-yl)phenyl]-1,3,4-oxadiazole derivatives (<strong>VIa-g</strong>) have been synthesized in good yields. These compounds were synthesized with an approach to reduce the growing anti-tubercular resistance and to develop more potent and less side effects having antitubercular activity. The reaction of 2,5-dimethoxytetrahydro furan with 4-aminobenzoate (<strong>II</strong>) in presence of ethanol, which yields ethyl 4-pyrrol-1-yl benzoate (<strong>III</strong>). This ethyl-4-pyrrol-1-yl benzoate (<strong>III</strong>) on reaction with hydrazine hydrate

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Al-Hussain, Sami A., Aya S. Saleh, Shimaa M. Abd El-Gilil, Hend M. El-Sehrawi, Elham M. Ezz Al-Arab, and Zeinab A. Muhammad. "Synthesis of Novel Cyano-Acetic Acid Hydrazide Derivatives as precursor for Generation of Dihydropyridine and Pyrrole as Anticancer Agents: Multi-Target Recognition, In Vitro and In Silico Studies." Journal of Molecular Structure, January 2025, 141501. https://doi.org/10.1016/j.molstruc.2025.141501.

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Joshi, S. D., H. M. Vagdevi, V. P. Vaidya, and G. S. Gadaginamath. "ChemInform Abstract: Synthesis of New 4-Pyrrol-1-yl Benzoic Acid Hydrazide Analogues and Some Derived Oxadiazole, Triazole and Pyrrole Ring Systems: A Novel Class of Potential Antibacterial and Antitubercular Agents." ChemInform 40, no. 10 (2009). http://dx.doi.org/10.1002/chin.200910100.

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C., S. Hallikeri* Poul Rubeza Sheshagiri R. Dixit Venkatarao H. Kulkarni Shrinivas D. Joshi. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRROLYL PYRAZOLINE METHANONE DERIVATIVES." March 31, 2018. https://doi.org/10.5281/zenodo.2531297.

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Novel pyrrolyl-pyrazoline methanone derivatives (5a-j) were synthesized by reacting mixture of substituted quinoline chalcones (3a-j) and 4-pyrrol-1yl benzoic acid hydrazide (4) in ethanol. The reaction mixture was heated under reflux for 16 h on a water bath followed by addition of ice cold water at room temperature and mixture was kept overnight resulting in the formations of substituted pyrrolyl-pyrazoline methanone derivatives. Purity of newly synthesized compounds were confirmed by TLC and melting point. The structure of the all newly synthesized compounds were confirmed by spectral study

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Georgieva, Maya, Diana Tzankova, Emilio Mateev, et al. "In Silico and In Vitro Determination of Antiproliferative Activity of Series N-Pyrrolyl Hydrazide-Hydrazones and Evaluation of Their Effects on Isolated Rat Mycrosomes and Hepatocytes." Anti-Cancer Agents in Medicinal Chemistry 22 (July 1, 2022). http://dx.doi.org/10.2174/1871520622666220701114306.

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Background: The significant increase of patients suffering from different types of cancer, guides scientists to take prompt measures in the development of novel and effective antiproliferative agents, where the intercalation of heterocyclic fragment in the designed molecules has proven to be a useful practice. Objective: The newly synthesized compounds were obtained from the corresponding 1,4-dicarbonyl derivative through multicomponent reactions to produce biologically active target molecules and assessed by in silico and in vitro assays for their possible antitumor activity. Methods: The pha

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