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Dissertations / Theses on the topic 'Qml'
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Pang, Wei. "QML-Morven a framework for learning qualitative models /." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25499.
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Plata, Cesar Nely. "Lenguaje de programación cuántico QML con historial, reversibilidad y cálculo lambda con mediciones." Tesis de doctorado, Universidad Autónoma del Estado de México, 2020. http://hdl.handle.net/20.500.11799/109464.
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Research in quantum computing allows us to think about computing in a new
and different way, having the ambition to solve problems more efficiently than
with classical computing.
Now a days, conventional tasks cannot be practically developed in a quantum
computer, however, it is possible to think and develop abstractions of them, for
example through quantum programming languages, being the core of this research,
in particular the Quantum Meta Language (QML).
We present a semantic model that incorporates reversibility via a history track
for the quantum programming language QML, considering classical and quantum
data, omitting measurements. With the history, the reversibility can be explicitly
and naturally applied from the proposed rules. The language is worked first with
classical data and extrapolated to quantum data.
Also, the QML language and quantum lambda calculus were linked, giving
as product a syntax with quantum measurements, operational semantics, typing
rules and some formal proofs.La investigación en el cómputo cuántico permite pensar de una forma nueva y diferente la computación, teniendo la ambición de solucionar problemas de manera más eficiente que con el cómputo clásico. Por ahora, las tareas convencionales no se pueden desarrollar de manera práctica en una computadora cuántica, sin embargo, sí se puede pensar y desarrollar abstracciones de éstas, por ejemplo a través de lenguajes de programación cuánticos, siendo el núcleo de esta investigación, en particular el lenguaje Quantum Meta Language (QML). Se presenta un modelo semántico que incorpora reversibilidad a través de una pista de historial para el lenguaje de programación cuántico QML, considerando datos clásicos y cuánticos, omitiendo mediciones. Con la pila de historial, la reversibilidad puede aplicarse explícita y naturalmente a partir de las reglas propuestas. El lenguaje se trabaja gradualmente, inicialmente con datos clásicos y un procedimiento similar al clásico se extrapola con datos cuánticos. Además, se vincularon los lenguajes QML y cálculo lambda cuántico, dando como producto una sintaxis con mediciones cuánticas, semántica operacional, reglas de tipado y ciertas pruebas formales.
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Голуб, В. О. "Програмне забезпечення редактора Dmotion Editor для створення проектів багатовимірних кінотеатрів." Master's thesis, Сумський державний університет, 2018. http://essuir.sumdu.edu.ua/handle/123456789/72285.
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В ході вирішення поставлених завдань було здійснено знайомство з принципами розвитку
десктопних програм, проаналізовано досвід роботи в області створення UI програм.
Так само була вивчена бібліотека Qt 5.5.1. В результаті чого стало можливим створення
графічного редактора. Цей процес детально описаний в роботі. Так само дана дипломна робота
може розглядатися як посібник з практичного використання можливостей бібліотеки.
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Ricciardelli, Marco. "Sviluppare applicazioni VoIP su Symbian: una corsa ad ostacoli." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amslaurea.unibo.it/2107/.
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Iannacone, Leonardo. "Ubuntu phone - un sistema operativo convergente per desktop e cellulari." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8510/.
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Ubuntu Touch è un nuovo sistema operativo per Desktop e Cellulari che nasce dalla necessità di unire sistemi eterogenei sotto un'unica piattaforma.
L'infrastruttura di Touch, che garantisce convergenza fra dispositivi diversi, è basata sull'innovativo server grafico Mir e sull'interfaccia grafica Unity.
L'Application Model è notevolmente migliorato, le applicazioni sono confinate attraverso AppArmor, e scambiano fra loro contenuti tramite il servizio Content-Hub. I tool di sviluppo supportati sono le tecnologie web (HTML5 e JavaScript) e C++ su Framework Qt (possibilità di utilizzare QML).
Gli aggiornamenti di sistema, del core, sono sia parziali, attraverso archivi "delta" che introducono solo i cambiamenti necessari, sia full, sovrascrivono l'intero dispositivo.
Lo sviluppo in Ubuntu SDK è veloce e agile. Notevole la gestione degli emulatori, ma pecca di alcune feature tutt'ora mancanti. Gli Scope sono application content indipendent, vera innovazione in Ubuntu. Per sperimentare questa tecnologia si sviluppa uno scope per la ricerca di libri nella Biblioteca Gian Paolo Dore della Facoltà di Ingegneria di Bologna.
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Boháč, Václav. "Evidence žáků zájmového spolku při ZŠ." Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-259082.
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The diploma thesis deals with the analysis, development and implementation of software using Qt framework. It reflects the history of the parents´ association and its need to register pupils attending a primary school, respectively members of the association. The diploma thesis goes through the various phases of design and development software using the Open Unified Process methodology and its subsequent processing using UML. The outputs from the analytical and design parts are then used to implement a custom registration system. This paper describes and compares several methods currently used in software development and introduces the reader to the basic principles of object-oriented programming. It provides an overview of the components and principles of processing framework Qt 5, the SDK development environment and the consequences resulting through practical uses when developing applications.
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Belica, Martin. "Vývoj univerzálního softwarového rozhraní pro detekční jednotky v optické spektroskopii." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-413006.
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This master's thesis deals with the design and implementation of universal user interface for detection devices used in Laser-induced breakdown spectroscopy. The design and implementation are based on analysis of current state of instrumentation used in laser spectroscopy. The user interface should be able to work with high repetition frequency of measurement. Acquired spectra should be visualised to user and it is also necessary to save this data on hard drive. The resulting application must be universal. It means the application must support various types and vendors of detection devices.
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Eriksson, Rickard, and Sajjadali Hemani. "A Cross-Platform Health Care Application." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-186884.
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This report describes the development process of the mobile application HealthyWay. The application is developed as a Bachelor thesis project together with KTH Royal Institute of Technology. The applications' main function is to be the interface to a number of wearable medical electronic appliances such as bandages and pill boxes. The communication is done through Bluetooth Low Energy. The application was mainly written in 3 di erent languages, QML, C++ and Java. The most stressed point throughout this project was the importance of platform independence. The exibility had to be done on a scalable as well as on a modular level. With this in mind, QT was used to address the requirement of scalability. The modularity was achieved through an organized structure to the program accompanied by easy directives to introduce new devices. The purpose of the application is to increase the quality of life for the user. This intent could however not be concluded due to the lack of testing among users. In its current state, the application is not yet ready for deployment but instead acts as a framework for future prospects.Den här rapporten beskriver utvecklingsprocessen för en mobilapplikation vid namn Healthy- Way. Applikationen är utvecklad som ett kandidatexamensarbete tillsammans med KTH. Applikationens huvudsakliga uppgift är att vara ett gränssnitt till medicinskt relaterad utrustning såsom plaster och pilleraskar. Kommunikationen mellan dessa sker via Bluetooth Low Energy. Applikationen skrevs huvudsakligen i 3 olika språk, QML, C++ och Java. Den viktigaste punkten genom projektets gång var att applikationen skulle vara oberoende av plattform. Flexibiliteten var tvungen att göras på både en skalbar och modulär nivå. Med detta i åtanke valdes QT för att behandla skalbarheten. Modulariteten uppnåddes genom en välplanerad struktur på programmet tillsammans med instruktioner på hur ny utrustning kan introduceras. Syftet med programmet är att öka livskvaliteten för användaren. Detta syfte kunde däremot inte slutföras på grund av bristande testning hos användare. I dagens läge är applikationen inte redo för att släppas kommersiellt, men tjänar som ett bra ramverk för framtida utveckling.
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Poignard, Benjamin. "Approches nouvelles des modèles GARCH multivariés en grande dimension." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLED010/document.
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Ce document traite du problème de la grande dimension dans des processus GARCH multivariés. L'auteur propose une nouvelle dynamique vine-GARCH pour des processus de corrélation paramétrisés par un graphe non dirigé appelé "vine". Cette approche génère directement des matrices définies-positives et encourage la parcimonie. Après avoir établi des résultats d'existence et d'unicité pour les solutions stationnaires du modèle vine-GARCH, l'auteur analyse les propriétés asymptotiques du modèle. Il propose ensuite un cadre général de M-estimateurs pénalisés pour des processus dépendants et se concentre sur les propriétés asymptotiques de l'estimateur "adaptive Sparse Group Lasso". La grande dimension est traitée en considérant le cas où le nombre de paramètres diverge avec la taille de l'échantillon. Les résultats asymptotiques sont illustrés par des expériences simulées. Enfin dans ce cadre l'auteur propose de générer la sparsité pour des dynamiques de matrices de variance covariance. Pour ce faire, la classe des modèles ARCH multivariés est utilisée et les processus correspondants à celle-ci sont estimés par moindres carrés ordinaires pénalisésThis document contributes to high-dimensional statistics for multivariate GARCH processes. First, the author proposes a new dynamic called vine-GARCH for correlation processes parameterized by an undirected graph called vine. The proposed approach directly specifies positive definite matrices and fosters parsimony. The author provides results for the existence and uniqueness of stationary solution of the vine-GARCH model and studies its asymptotic properties. He then proposes a general framework for penalized M-estimators with dependent processes and focuses on the asymptotic properties of the adaptive Sparse Group Lasso regularizer. The high-dimensionality setting is studied when considering a diverging number of parameters with the sample size. The asymptotic properties are illustrated through simulation experiments. Finally, the author proposes to foster sparsity for multivariate variance covariance matrix processes within the latter framework. To do so, the multivariate ARCH family is considered and the corresponding parameterizations are estimated thanks to penalized ordinary least square procedures
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Teixeira, Cornélio Zampier. "Capacidade de carga de sapatas, estacas de pequeno diâmetro e tubulões curtos em função do SPT: um estudo em solos residuais de Gnaisses para a região Sul de Minas." Universidade de São Paulo, 1997. http://www.teses.usp.br/teses/disponiveis/18/18132/tde-10052018-104421/.
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Esta Tese aborda, de modo original e pioneiro, importantes aspectos da Engenharia de Fundações do Sul de Minas: a) sistematização de conhecimentos sobre a Geologia regional; b) identificação e caracterização da prática de fundações; c) definição (com a formação de um banco de dados) dos perfis mais representativos do subsolo de suas principais cidades; d) estudo dos parâmetros físicos, químicos e geomecânicos de um solo típico; e) implantação de campo experimental de fundações da Universidade Federal de Lavras, com a realização de provas de carga. Grande ênfase foi dada aos itens (a), (c) e (e). Priorizou-se o estudo das fundações de baixa capacidade de carga, no estudo do comportamento carga-recalque de ensaios de placa, de provas de carga a compressão em estacas-broca isoladas e de tubulões curtos instrumentados. Destacam-se as análises sobre os efeitos de forma, profundidade, melhoramento do terreno de fundação e de inundação nas fundações rasas e da variação L/d na resistência lateral unitária das estacas, sendo valorizadas as fórmulas empíricas com base no SPT. São apresentadas fórmulas de previsão de carga, em função do SPT, para sapatas, estacas de pequeno diâmetro e tubulões curtos e um estudo de custos, onde se mostra que a opção indiscriminada por tubulões é inadequada para certas faixas de carga de trabalho. Adicionalmente, são feitas recomendações para intensificar o uso de sondagens tendo em vista a grande variabilidade das propriedades dos solos regionais e para aumentar os fatores de segurança nestas fórmulas onde houver possibilidade de ocorrência de colapso no solo.This work presents, at time, important aspects of Foundation Engineering at Southern Region of Minas Gerais State: a) systematization of the knowledge about regional geology; b) identification and characterization of practice in foundations; c) definition (though establishment of a data base) of most representative sub-soil profiles at main cities at the region; d) study of physical, chemical and geomechanical parameters of a typical soil; e) implementation of a experimental field for foundation studies at Federal University of Lavras, by execution of load tests. A large emphasis was given to items a, c and e. The study of foundations of low load capacity was prioritized when testing plates, isolated piles under compression and short drilled piers with sensors. Analysis such as form effects, depth, soil improvement and flooding on shallow foundations and variation of L/d on the lateral unity resistance by emphasizing the empiral equations based on SPT were all pointed out. Mathematical equations are presented for load estimation as function of SPT for small diameter piles and short drilled piers as well as a cost study where it can bem shown that the undistinguished alternative for piers is inadequate for some load values. In addition, due to soil spatial variability and safety factor increment on soils subject for colapse, recommendations on intensive use of SPT test are given.
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Saunders, Emily Louisa Rose. "The evolution of hominoid ecomorphology studies of locomotor behaviour and anatomy in human and nonhuman apes." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7243/.
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An animal’s locomotor abilities facilitate its interactions with the surrounding environment. Extant hominoids (apes) have evolved diverse ranges of locomotor strategies which allow them to exploit terrestrial and arboreal habitats despite their large body size. However, hominins (modern humans and their ancestors) are traditionally defined by their restriction to upright, bipedal posture and locomotion. Reconstructions of locomotor capacity in fossil hominoids allow investigation of the evolution of extant ape locomotion; yet these reconstructions rely on detailed understanding of the relationships between morphology, locomotor behaviour and the environment in extant apes. This thesis explores variation in locomotor behaviour and skeletal morphology among extant apes in order to shed light on these relationships. Studies of chimpanzees, gorillas and modern humans reveal considerable mechanical variation in gait, and demonstrate the importance of considering environmental context in ape locomotion. Anatomical studies find reduced reliability of inferring locomotor capacity in fossil hominoids due to significant variation among extant apes in skeletal predictors of habitual bipedality and estimations of joint range of motion. These studies highlight the importance of behavioural flexibility in determining hominoid locomotor capacity, and suggest that fossil hominoids were less constrained in their locomotor repertoires than previous reconstructions imply.
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Hanson, Nardie Kathleen Igraine. "Cognitive and locomotor strategies of arboreal locomotion in non-human apes and humans." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7122/.
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Arboreal travel for large apes is energetically demanding and risky due to the complexity of the forest canopy. Careful selection of supports is therefore essential for safe and efficient locomotion. This thesis investigates the factors involved in route and support selection in bonobos (Pan paniscus) and in modern human (Homo sapiens) tree climbers. Naturalistically housed bonobos were given a choice of two ropes, one that provided easy access and another that required more demanding postures, with which to access a hard-to-reach food goal. The bonobos selected a rope based on its distance from the goal and its flexibility. Decision making in human tree climbers was investigated using a novel combination of qualitative (participant interviews) and quantitative (observations of behaviour) data. Participants were asked to collect goals from within a tree crown three times each. Interviews revealed that participants either considered risk avoidance or ease/efficiency as the main factor influencing their decisions whilst climbing. Those considering risk took longer to complete each climb, but became quicker after their first climb. These studies demonstrate that the demands of the arboreal environment require knowledge of the functional properties of supports and that memory of specific routes may increase the efficiency of arboreal locomotion.
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Kopecký, Lukáš. "QMS průmyslového podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2016. http://www.nusl.cz/ntk/nusl-254327.
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The subject of this master´s thesis is the improvement of a quality management system in selected industrial company using the DMAIC methodology. For this purpose, current status of quality management system was analysed and compared with requirements of the ČSN EN ISO 9001 standard. Based on determined shortcomings, corrective measures were proposed. The measures related to process management and risk analysis were performed within the pactical part of this thesis.
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Xing, Liqun 1962. "Marker density, marker distribution and QTL-by-environment interaction in QTL mapping." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36734.
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Two studies were conducted on gene mapping analysis. For the first study, genetic simulation experiments were conducted to address the effects of marker density, method of mapping analysis, and gaps in a marker map on the efficiency of QTL detection and the accuracy of QTL parameter estimation. The simulated genome consisted of seven chromosomes with seven or eight segregating QTL affecting the simulated quantitative trait. A set of six randomly segregating QTL outside the test region was consistently used to represent 40% of phenotypic variation. An individual QTL or a linkage block of two QTL on a target chromosome contributed 10% of phenotypic variation. The marker map was either dense (with markers every 4 cM) or sparse (with markers every 20 cM). The gap in the marker map was either 32 cM or 56 cM. Interval mapping and composite interval mapping were used to map QTL on the target chromosome. A dense map provided more power of QTL detection, better accuracy of QTL parameter estimation, and higher false-positive error rates for the target chromosome than a sparse map. Composite interval mapping provided more power of QTL detection, better accuracy of QTL parameter estimation, and lower false-positive error rates than interval mapping. Presence of a large gap in a marker map affected QTL detection and QTL parameter estimation for a QTL inside or near the gap. The use of a dense map with composite interval mapping was the most efficient combination tested in this study. For the second study, a mixed factorial regression model for interval mapping was developed for conducting QTL-by-environment interaction analysis and for providing inferences about QTL that are applicable beyond the environments used in the experiments. Genetic simulation was used to test the model for the power of detecting QTL-by-environment interaction and identifying the types of such interaction as crossover or non-crossover, and for the accuracy of estimating QTL parameters. The model prov
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Xing, Liqun. "Marker density, marker distribution and QTL-by-environment interaction in QTL mapping." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0034/NQ64696.pdf.
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Mbenza, Alexandre Seth da Silva. "Quality Manager System (QMS)." Master's thesis, Instituto Politécnico de Setúbal. Escola Superior de Tecnologia de Setúbal, 2019. http://hdl.handle.net/10400.26/31330.
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Relatório de projeto do Mestrado em
Informática de GestãoA evolução tecnológica a nível da indústria e de metodologias utilizadas torna imperativo que as organizações adotem novos mecanismos e que estas novas tecnologias reflitam uma maior eficiência para as mesmas. Neste contexto, as organizações apostam cada vez mais na gestão da qualidade, encarando-o como uma ferramenta eficaz para fazer face à competitividade nacional e internacional. Não menosprezam toda a atividade relacionada com a inovação, mas consideram que é fundamental uma base com qualidade, permitindo assim atingir patamares superiores. O presente relatório visa abordar a metodologia e o processo de implementação das normas internacionais a nível geral. O conhecimento adquirido ao longo do percurso profissional no desenvolvimento de um software, bem como em outras competências intrínsecas, permitiram idealizar o desenvolvimento de uma plataforma capaz de gerir e implementar um sistema de gestão de qualidade. com o intuito de que este seja capaz de evoluir e de ser mantido de forma organizada. Com a implementação da ISO 27001, neste contexto, e após a análise de soluções existentes no mercado e da estrutura de implementação e certificação das normas internacionais, surgiu a necessidade de apresentar uma solução que vise facilitar este mesmo processo e que também ajude na manutenção de um sistema de gestão. Para este desenvolvimento foi necessário efetuar um levantamento de alguns sistemas que já existiam nesta área, sendo que as soluções encontradas no mercado não satisfaziam a necessidade de um sistema de gestão de qualidade. Apesar destas permitirem gerir este tipo de sistemas de qualidade, não estão focadas no processo de implementação e certificação das ISO. Deste modo, o QMS4.0 tem como objetivo minimizar esta lacuna identificada e facilitar o processo interno das empresas.
Technological developments in industry and in the methodologies used make it imperative for organizations to adopt new mechanisms and new technologies and to reflect on greater efficiency. In this context, organizations are increasingly focusing on quality management, seeing it as an effective tool to address national and international competitiveness. They do not underestimate all innovation-related activity, but considering that, a quality base is fundamental, thus allowing to reach higher levels. This report aims to address the methodology and process of implementation of international standards at the general level. The knowledge acquired along the professional career in software development as well as in other intrinsic skills allowed us to idealize the development of a platform capable of managing and implementing a quality management system in order to be able to evolve and to develop. be kept in an organized manner. With the implementation of ISO 27001 in this context, and after the analysis of existing solutions in the market and the structure of implementation and certification of international standards emerged the need to present a solution that aims to facilitate this same process and that also helps in maintaining a system management. For this development, it was necessary to make a survey of some systems that already existed in this area, and the solutions found in the market did not satisfy the need for a quality management system. Although these allow the management of such quality systems, they aren’t focused on the ISO implementation and certification process. This QMS4.0 aims to minimize this identified gap and facilitate this internal process of companies.
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Bauman, Lara Elizabeth. "QTL variance component models." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1464110531&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
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Yalçin, Biannaz. "QTL mapping in animal models." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410716.
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Filla, Michal. "Návrh QMS v malé organizaci." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228038.
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This Diploma thesis is engaged in implementation of quality management system in a small organization. In this thesis is closely described quality management system, its advantages and rules. There was made an entry analysis and documentation was checked and completed.
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Husák, Adam. "Zlepšení QMS organizace aplikací DMAIC." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2013. http://www.nusl.cz/ntk/nusl-230527.
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The aim of this master´s thesis is to design an action to improve of selected process Design and development through DMAIC application. The thesis is focused on identifying the problem, finding the cause and following design of improves leading to eliminate problems. This improves will enable the company to achieve time savings during the process and reduce a risk of orders. Result of this is effective operation in the process.
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Heger, Jan. "Návrh QMS v malé organizaci." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2013. http://www.nusl.cz/ntk/nusl-230994.
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The thesis suggests quality management for small organizations and focuses on its implementation, using the DMAIC methodology in accordance with ČSN EN ISO 9001. First, a chosen small organization will be analysed; next, the key processes will be defined and their setting in accordance with ČSN EN ISO 9001 provided.
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Wahlberg, Per. "Chicken Genomics - Linkage and QTL mapping." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9502.
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Johansson, Sara. "QoL hos SiNETs patienter i Örebro." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73978.
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Bakgrund: SiNETs är neuroendokrina tumörer som utgår från tunntarmen och som kan ha förmågan attproducera hormoner. Hormonproduktionen kan ge en symtomkaskad bestående av diarré,flush, högersidiga hjärtklaffsvitier samt bronkobstruktion. Den kurerande behandlingen vidNETS är radikal kirurgi. Utöver detta kan behandling med främst somatostatinanalogererbjudas. Dessa syftar till att hämma utsöndringen av hormon vilket lättar symtombördan. NETs är generellt en långsamtväxande tumör med en lång förväntat överlevnad trotsmetastaser. Lång förväntad överlevnad gör det intressant att undersöka hur patienterna skattarsin livskvalitet. Syfte: Granska hur SiNETs patienterna i Örebro upplevde sin livskvalité - ”quality of life”. Detta varett kvalitetsarbete för Kirurgiska kliniken USÖ. Metod: Två enkäter från EORTC; QLQ C30 och QLQ GI.NET21, användes. Enkäternakompletterades med en journalgranskning. Data avkodades och sammanställdes i Excel ochpresenterades i tabell och diagramform. Resultat: Resultatet för QoL var relativt lika i de grupper som Örebromaterialet jämfördes med.Örebropatienterna upplevde sin funktionsgrad högre än patienterna i den LundbaseradeMilanetto et al studien. Patienterna i Lund hade haft svårt att hitta information om sitttillstånd, upplevde social och sexuell funktion lägre än Örebro samt beskrev i högre grad attderas sjukdom påverkade deras ekonomiska situation. Örebropatienterna upplevde sinfunktionsgrad högre än vad referensmaterialet gjorde. Graden av symtom skiljde sig mellanÖrebro och referensmaterialet. I Örebro var Dyspné och diarré de symtom som förekom mestfrekvent. Slutsatser: Patientmaterial från Örebro följde samma trend vad gällde QoL och grad av symtom somhade visats i tidigare studier bla Milanetto et al. Ett större material krävs från Örebro för att kunna dra mer långtgående slutsatser.
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France, Neil. "Residual Gas Analysis Using Minature QMS Systems." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507192.
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Hu, Wei-Hua. "The use of QTL in Hebrew aphorism." Theological Research Exchange Network (TREN), 2001. http://www.tren.com.
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QUADROS, I. P. S. "MAPEAMENTO E DETECÇÃO DE QTL EM MANDIOCA." Universidade Federal do Espírito Santo, 2016. http://repositorio.ufes.br/handle/10/7844.
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Previous issue date: 2016-08-31A mandioca é típica dos trópicos e fonte de segurança alimentar para mais de 600 milhões de pessoas, utilizada na alimentação humana e animal e na indústria, pela extração de amido e produção de biocombustível. O Brasil é o segundo país em produção, entretanto o incremento em produção é baixo para atender o crescente mercado. A compreenção da arquitetura genética de caracteres agronomicamente importantes é útil para delinear cruzamentos e possibilita a identificação de loci controladores de características quantitativas (QTL), no intuito de seleção assistida e clonagem de genes candidatos. Neste trabalho objetivou-se identificar, mapear e caracterizar QTL para as características de altura das plantas (AP), produtividade de parte aérea (PPA), produtividade total de raízes fresca (PTR), teor de matéria seca da raiz (MS) e produtividade de amido (PROD-AMD) de mandioca. Para isto foi utilizada uma população F1 de 141 indivíduos, oriunda do cruzamento entre as cultivares Fécula Branca e BRS Formosa, mantida em delineamento em blocos, com duas repetições e 16 plantas por parcela para as análises fenotípicas. A genotipagem dos indivíduos foi realizada usando SNPs, microssatélites e minissatélites. O mapa foi construído com abordagem multiponto e a detecção dos QTL realizada por análise de contraste entre médias e intervalo, considerando os diferentes tipos de segregação do QTL. Variabilidade foi observada para todas as características e altas correlações fenotípicas, exceto para MS, com destaque para PTR e PROD-AMD (0,98), bem como alta herdabilidade para AP (74,29%). Também, segregação transgressiva foi detectada para todas as características, indicando complementariedade de alelos dos pais na progênie segregante. O mapa genético representou regiões dos 18 cromossomos da mandioca e foi composto por 283 marcadores em 32 grupos de ligação. Uma região do cromossomo 10 apresentou evidência de pleitropia. Para AP, PPA e PROD-AMD um QTL comum foi identificado, bem como para PTR e PROD-AMD, três QTL comuns foram verificados. O MS apresentou QTL exclusivos. Estes resultados indicam o controle quantitativo das características estudadas, com QTL de grande e pequeno efeito detectados. Estes são úteis no melhoramento da cultura visando maior produtividade.
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Wang, Austin T. "Allele-Specic QTL fine-mapping with PLASMA." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/129928.
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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, February, 2020Cataloged from student-submitted PDF of thesis.
Includes bibliographical references (pages 35-37).
We introduce PLASMA (PopuLation Allele-Specic MApping), a statistical ne- mapping method that leverages allele-specic (AS) genomic data to improve detection of quantitative trait loci (QTLs) with causal effects on molecular traits. In simulations, PLASMA accurately prioritizes causal QTL variants over a wide range of genetic architectures. Applied to RNA-Seq data from 524 kidney tumor samples, PLASMA achieves a greater power at 50 samples than conventional QTL-based ne-mapping at 500 samples: with over 17% of loci ne-mapped to within 5 causal variants compared to 2% by QTL-based ne-mapping, and a 6.9-fold overall reduction in median credible set size. PLASMA offers high accuracy even at small sample sizes, yielding a 1.3-fold reduction in median credible set size compared to QTL-based ne-mapping when applied to H3K27AC ChIP-Seq from just 28 prostate tumor/normal samples. Our results demonstrate how integrating AS activity can substantially improve the detection of causal variants from existing molecular data.
by Austin T. Wang.
M. Eng.
M.Eng. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science
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Ljungberg, Kajsa. "Numerical methods for mapping of multiple QTL." Licentiate thesis, Uppsala universitet, Avdelningen för teknisk databehandling, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-86133.
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This thesis concerns numerical methods for mapping of multiple quantitative trait loci, QTL. Interactions between multiple genetic loci influencing important traits, such as growth rate in farm animals and predisposition to cancer in humans, make it necessary to search for several QTL simultaneously. Simultaneous search for n QTL involves solving an n-dimensional global optimization problem, where each evaluation of the objective function consists of solving a generalized least squares problem. In Paper A we present efficient algorithms, mainly based on updated QR factorizations, for evaluating the objective functions of different parametric QTL mapping methods. One of these algorithms reduces the computational work required for an important function class by one order of magnitude compared with the best of the methods used by other authors. In Paper B previously utilized techniques for finding the global optimum of the objective function are compared with a new approach based on the DIRECT algorithm of Jones et al. The new method gives accurate results in one order of magnitude less time than the best of the formerly employed algorithms. Using the algorithms presented in Papers A and B, simultaneous search for at least three QTL, including computation of the relevant empirical significance thresholds, can be performed routinely.
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Ma, Junwu. "Genome-wide QTL mapping for complex traits in pigs and focusing analysis on fatness QTL on porcine chromosome X." Toulouse 3, 2009. http://thesesups.ups-tlse.fr/584/.
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Les buts de cette thèse étaient l'acquisition de connaissances sur l'architecture génétique de caractères complexes et l'étude de la variabilité des taux de recombinaison chez le porc. La première partie de cette thèse présente une analyse sur l'ensemble du génome des locus influençant des caractères quantitatifs (QTL) au sein de croisements F2 entre des verrats de race Duroc blanc et des truies Erhulian, protocole développé en Chine à l'université d'agriculture du Jiangxi (JXAU). La population étudiée dans le cadre de cette thèse regroupe de 750 à 1030 animaux F2 mesurés sur 80 caractères concernant la composition de la carcasse (17 caractères), la qualité de la viande (58 caractères) et les caractères morphologiques des oreilles (5 caractères). Au total nous avons identifié 253 QTL pour ces caractères, dont la moitié est significatif au niveau du génome entier. Les chromosomes rassemblant le plus de QTL pour ces caractères sont les chromosomes 4, 7, 8 & X. Les niveaux de signification les plus élevés sont observés pour un (ou des) QTL affectant la longueur de carcasse, le poids de la tête et le poids des oreilles situé au sein d'un intervalle de 3 cM situé sur le chromosome 7 (Sw1856-S0066) expliquant jusqu'à 50 % de la variance phénotypique. L'allèle Duroc blanc étant l'allèle favorable pour une majorité des QTL affectant la composition de la carcasse, tandis que les allèles favorables pour la qualité de la viande présentent des origines tantôt asiatique tantôt européenne. L'INRA avait réalisé il y a près de 20 ans un programme de détection de QTL entre animaux Large White & Meishan. La localisation parallèle sur le chromosome X de QTL influençant l'engraissement et la muscularité des animaux au sein des pédigrées français et chinois nous a amené a travaillé sur la cartographie fine de ce(s) QTL qui a été développée dans la deuxième partie de cette thèse réalisée en cotutelle. Dans un premier temps afin de préciser la position du QTL située sur le chromosome X, nous avons étudié les variations de taux de recombinaison entre différentes régions du chromosome ainsi que les variations inter individuelles. .The aims of this thesis are to gain knowledge on genetic architecture of complex traits and on fine-scale structure of recombination rate variation in pigs. The first part of this thesis presents a genome-wide scan for quantitative trait loci (QTL) in a cross between White Duroc boars and Erhualian sows that was developed at Jiangxi Agricultural University (JXAU) in China. The mapping population comprised 750-1030 F2 individuals that were evaluated for a total of 80 traits related to carcass composition (17 traits), meat quality (58 traits) and ear traits (5 traits). In total, we identified 253 QTL for these traits, of which about half reached genome-wide significance level. Numerous QTL for these traits have been found on porcine chromosomes 4, 7, 8 and X. The greatest significance levels were found for a QTL affecting carcass length, head weight and ear weight on SSC7 in an interval of 3 cM (SW1856-S0666), which explained up to 50% of the phenotypic variance. White Duroc alleles at a majority of QTL detected were favorable for carcass composition, while favorable QTL alleles for meat quality originated from both White Duroc and Erhualian. INRA performed a genome scan to reveal QTL in a Large White × Meishan cross 8 years ago. Coincidently, both INRA and JXAU mapped strong QTL for fatness and muscling traits in a similar region of the porcine chromosome X (SSCX). Thus, both sides wished to collaborate to fine map the QTL. .
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Eberhartinger, Eva, and Martin Six. "National Tax Policy, the Directives and Hybrid Finance. Options for tax policy in the context of the treatment of Hybrid Financial Instruments in the Parent-Subsidiary Directive and the Interest and Royalties Directive." SFB International Tax Coordination, WU Vienna University of Economics and Business, 2006. http://epub.wu.ac.at/896/1/document.pdf.
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Winn, Jennifer Ann. "QTL mapping of high digestibility trait in sorghum bicolor (L.) Moench." Thesis, [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2582.
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Prashar, Ankush. "Arabidopsis QTL analysis using stairs and gene expression." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435316.
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Edwards, Kieron David. "Mapping circadian temperature compensation QTL in Arabidopsis thaliana." Thesis, University of Warwick, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396973.
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Banerjee, Samprit. "Bayesian genome-wide QTL mapping for multiple traits." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/banerjee.pdf.
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Hsu, Allen Long. "Design of high efficiency Mid IR QCL lasers." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45832.
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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.Includes bibliographical references (p. 101-103).
The proposed research is a study of designing high-efficiency Mid-IR quantum cascade lasers (QCL). This thesis explores "injector-less" designs for achieving lower voltage defects and improving wall plug efficiencies through highly strain-balanced structures and minimized injector regions. This work contains experimental design work for testing and evaluating Mid-IR QCL performance, simulation work for verifying wavefunction and energy alignment, as well as, Monte Carlo transport simulations for evaluating designs, and finally measuring lasing and spontaneous emission performance for various designs.
by Allen Long Hsu.
S.M.
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Bayer, Robert. "Rozšíření zavedeného QMS ve firmě Spojmont Ostrava s.r.o." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2015. http://www.nusl.cz/ntk/nusl-221078.
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The aim of this thesis is to familiarize with tools used in quality management and with methods of their application and to apply some of the tools in a real company. Among these tools there are a handbook for integrated management system of QMS on the basis of standard EN ISO 9001:2008, EMS on the basis of standard EN ISO 14001:2005 and ČSN OHSAS 18001:2008, 5S system, process FMEA and application of Pareto analysis on complaints. All the tools are attached to the dissertation thesis in electronic appendixes.
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Guzman, Jessica Lorena Gonzalez. "Análise genômica de associação global e prospecção de genes relacionados à características de tipo de bubalinos leiteiros /." Jaboticabal, 2017. http://hdl.handle.net/11449/190828.
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Orientador: Humberto TonhatiResumo: No primeiro capítulo foi proposto um estudo de associação das informações genômicas com características de tipo, a fim de identificar regiões cromossômicas e genes possivelmente relacionados à altura, peso, crescimento e fatores de conformação corporal. Utilizou-se um painel de 49.010 marcadores SNPs (322 animais) conjuntamente com informações de pedigree (674 animais). As analises foram processadas através do programa Blup.f90, utilizando-se a metodologia de single-step (ssGBLUP). Somente as janelas com 10 SNPs adjacentes e que explicavam acima de 1,5% de variância genética aditiva, foram considerados. Os genes SYT10, GKAP1, C9orf64 e PHLPP1 foram identificados para a característica altura da cernelha (ALTC) e apresentam influência para crescimento, altura e desenvolvimento ósseo. Também foi reportado um QTL para ALTC influenciando crescimento e fertilidade. Foram encontrados SNPs localizados em regiões cromossômicas que ainda não foram previamente descritos com QTL para as características em estudo em búfalos. No segundo capítulo, foram estimados os parâmetros genéticos/genômicos para as características produção de leite acumulada aos 305 dias (PLDC) e caracteristicas de tipo altura da cernelha (ALTC), altura da garupa (ALTG), comprimento do corpo (COMPC), comprimento da garupa (COMPG), Largura entre os íleos (LILE), Largura entre os ísquios (LISQ) e perímetro torácico (PERTOR) em búfalos da raça Murrah utilizando modelos bicaracterísticos. As estimativas de herdabilidade f... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: In the first chapter we proposed a study of the association of genomic information with type characteristics, in order to identify chromosomal regions and genes possibly related to height, weight, growth and body conformation factors. Were used one panel of 49,010 SNPs markers (322 animals) together with pedigree information (674 animals). The analyzes were processed through the Blupf90 program, using the singlestep methodology (ssGBLUP). Only the windows with 10 adjacent SNPs and, that explained above 1.5% of additive genetic variance, were considered. The genes SYT10, GKAP1, C9orf64 and PHLPP1 were identified for the characteristic height of the withers (ALTC) and presented influence on growth height and bone development. It has also been reported a QTL for ALTC influencing growth and fertility. SNPs were found located in chromosomal regions which have not previously been described with QTL for the characteristics under study in buffaloes. In the second chapter, were estimated the genetic / genomic parameters for the characteristics accumulated milk production at 305 days (AMP) and characteristics of the withers height (WH), croup height (CH), body length (BL), croup length (CL), Width between hip bones (WBHB), Width between pin bones (WBPB) and thoracic perimeter (TP) in Murrah buffaloes using characteristic models. Genetic correlations were 0.603 between AMP and WH, 0.898 between WBHB and BL, 0.867 betwwen AMP and CL, 0.887 between AMP and TP, 0.774 between WBHB and WBPB,... (Complete abstract click electronic access below)
Mestre
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Marti, Raga Maria. "Environmental and genetic factors affecting Saccharomyces cerevisiae performance during second fermentation." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0185/document.
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La méthode traditionnelle utilisée pour produire des vins mousseux (comme cava et champagne) est caractérisée par une seconde fermentation qui a lieu à l'intérieur de la bouteille. Cette deuxième fermentation présente des caractéristiques très spécifiques telles qu’une teneur élevée en éthanol, la pression croissante de CO2, une basse température et une faible disponibilité des nutriments. Dans cette thèse, on a tout d'abord analysé l'effet des facteurs environnementaux sur la cinétique de fermentation de Saccharomyces cerevisiae au cours de la seconde fermentation. Deuxièmement, on a analysé l'effet de pratiques communes, telles que l'ajout de nutriments au vin de base, sur la composition finale du vin mousseux. Enfin, nous avons cherché à identifier la base génétique de la variabilité phénotypique observée pendant la seconde fermentation en utilisant une approche Quantitative Trait Locus (QTL). Les résultats obtenus ont permis de déterminer la température, le vin de base utilisé, la souche de levure et la source d'azote utilisée dans l'acclimatation de levure comme les facteurs qui ont la plus grande incidence dans la cinétique de la seconde fermentation. Deuxièmement, par rapport à la composition finale du vin mousseux, nous avons trouvé que l'addition d'azote dans le vin base favorise la libération des acides aminés. Bien que l'ajout de levure sèche inactive favorise la libération des polysaccharides et les propriétés moussantes du vin mousseux. Enfin, on a pu identifier quatre gènes dont la variation allélique explique la variation phénotypique observée parmi les souchesThe traditional method used to produce sparkling wines (such as cava and champagne) is characterized by a second fermentation that takes place inside the bottle. This second fermentation has very specific characteristics such as a high ethanol content, increasing CO2 pressure, low temperature and low nutrient availability. In this thesis, we have firstly analyzed the effect of environmental factors on fermentation kinetics of Saccharomyces cerevisiae during the second fermentation, by monitoring the second fermentation development using aphrometers. Secondly, we analyzed what is the effect of common practices such as adding nutrients to the base wine on the final composition of the sparkling wine by HPLC analysis of content of amino acids and polysaccharides and its foaming capacity (mosalux) of the sparkling wine. Finally we aimed to identify the genetic basis of the second fermentation using Quantitative Trait Locus (QTL) mapping and validation approach. The results obtained enabled us to identify the temperature, the base wine used, the yeast strain and source of nitrogen used in the acclimatization of yeast as the factors that have the highest impact in the second fermentation kinetics. Secondly, with respect to the final composition of sparkling wine, we have found that the addition of nitrogen to the wine base favors the release of amino acids. While the addition of inactive dry yeast, promotes the release of polysaccharides and favors the foaming properties of the sparkling wine. Finally, could identify four genes whose allelic variation explains the phenotypic variation observed among strains
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El, Farrah Khassan. "Breast cancer surgery QOL scale : development, validity, and reliability." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80255.
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The SF-36 scale is widely used to evaluate the quality of life among breast cancer patients, but provides an inadequate reflection of their quality of life; therefore, we aimed to set up a new scale, a breast cancer surgery quality of life (BCSQOL) scale and to assess its reliability and validity. The analysis review showed that 75% to 91% of surgically treated patients (59/79) found that the questionnaire items were an accurate reflection of their feelings and were clear. The validity coefficient analysis showed a highly correlated extent of commonality (alpha = 0.778) between BCSQOL and SF-36 and a significant strength of relationship (rho = 0.785). Strong to moderate correlation reliability coefficient analysis (alpha = 0.779--0.351) was observed for the association among all items of the scale. BCSQOL scale may help health care providers to better understand the health status of breast cancer subjects, rendering them more equipped to improve their quality of life.
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Taenzler, Bärbel. "QTL-Analyse der Backqualität in Einkornweizen (T. m. monococcum)." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=964783304.
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Sillanpää, Mikko. "Bayesian QTL mapping in inbred and outbred experimental designs." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/rolfn/vk/sillanpaa/.
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Fytrou, Anastasia. "Drosophila immunity : QTL mapping, genetic variation and molecular evolution." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4742.
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Drosophila is involved in a wide range of interactions with parasites and pathogens (parasitoid wasps, bacteria, fungi, viruses). Drosophila hosts vary greatly at the species, population and individual level, in their response against such organisms, and much of this variation has a genetic basis. In this thesis I explored three aspects of this variation. First, using recombination mapping based on SNPs and a variation of bulk segregant analysis, I identified a QTL region on the right arm of the third chromosome of D. melanogaster associated with resistance to at least some of the parasitoid species / strains used in the experiments. The location of the QTL was further explored with deficiency complementation mapping and was narrowed down to the 96D1-97B1 region. The success of the deficiency mapping suggests that the resistant allele is not completely dominant. Second, I investigated patterns of molecular evolution in a set of immunity-related genes, using sequences from a D. melanogaster and a D. simulans population and a set of genes without known involvement in immunity for comparison. I found evidence that several of these genes have evolved under different selection pressure in each species, possibly indicating interactions with different parasites. The immunity genes tested appear to be evolving faster compared to non-immunity genes, supporting the idea that the immune system is evolving under strong selective pressure from parasites. Finally, in a D. melanogaster – sigma virus system, I measured genetic variation in the transmission of different virus genotypes, in different environments. There was poor correlation between temperatures, suggesting that environmental heterogeneity could constraint evolution of resistance (to virus transmission). The correlation between viral genotypes was also low, although relatively stronger for more closely phylogenetically related viral strains. Such interactions between host genotypes, virus genotypes and environmental conditions can maintain genetic variation in virus transmission.
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Gautier, Mathieu Yves Anthony. "Cartographie fine de régions QTL chez les bovins laitiers." Paris, Institut national d'agronomie de Paris Grignon, 2003. http://www.theses.fr/2003INAP0008.
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Shenkman, Rustin M. "Quadrupole Magnetic Sorting (QMS) of Porcine Islets of Langerhans." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1229640573.
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Sena, Juliana Stival. "Mapeamento e caracterização de microssatélites derivados de sequências expressas (EST) e análise de coincidência de QTL em Eucalyptus spp. em ambientes contrastantes." Universidade Federal de Viçosa, 2009. http://locus.ufv.br/handle/123456789/4702.
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The first part of this work involved the development and genetic mapping of a new battery of microsatellites for Eucalyptus derived from ESTs. Screening of 232 microsatellites derived from ESTs was carried out using a panel of 12 individuals corresponding to the parents used for population development in the Genolyptus project. Among the successfully amplified loci, 78% were polymorphic and showed complete inter-specific transferability. Thirty six loci were selected for mapping based on the amplicon size (< 400 pb), repeat motif and positive BLAST with interesting genes in public databases. With the objective of mapping, 36 loci were evaluated with regard to polymorphism and segregation in a reference segregating population derived from a cross between E. grandis x E. urophylla. The proportion of loci segregating in a fully informative configuration was about 40% lower than the one seen for microsatellites derived from genomic-enriched libraries. In spite of a relatively lower genetic information content, these loci are interesting for mapping, as they correspond to genes, allowing comparative mapping and potential co-location with QTL. Among the informative loci, 20 were successfully mapped in the particular reference mapping population. These mapped loci were characterized for polymorphism information content. Although EST derived microsatellites are generally less informative than those derived from non coding genomic regions they can be effectively used for individual identification, paternity analysis, evaluation of genetic diversity, certification of controlled crosses, genetic mapping and marker-assisted selection. In the second part of this work the coincidence in QTL detection was investigated by comparing the position and magnitude of effect of QTLs for wood and growth properties in three partially connected segregating populations of Eucalyptus spp. in two contrasting environments (Guanhães-MG and Guaíba-RS) over 3,000 km apart in a north-south latitude gradient. The families studied were: (E. camadulensis) x (E. urophilla x E. globulus), C1 x UGL, (E. dunnii x E. grandis) x (E. urophylla x E. globulus), DG x U2, and (E. dunnii x E. grandis) x (E. uropyilla), DG x UGL. Microsatellite markers flanking QTLs mapped in previous studies in these three families in Guaíba-RS were selected for the coincidence study. These markers were mapped using different sets of individuals from the same three families planted in Guanhães-MG. QTLs for eight quantitative traits related to wood and growth properties were studied. Two QTL (height and depth of pilodyn penetration, i.e. wood density) were detected in common for the two environments in the UGL parent (cross C1 x UGL); two (lignin content and pulp yield) in parents DG and U2 respectively (cross DG x U2) and four QTLs (two for diameter at breast height, one for height and one for volume), two of them colocalized with QTLs for biologically correlated traits (r > 0.8), in the parent UGL (cross DG x UGL). Furthermore, three QTLs (diameter at breast height, height and pilodyn penetration depth) located on linkage group 6 of the parent UGL were stable across the different genetic backgrounds and environments. Results indicate that QTLs of major effect for wood property traits are consistently detected in contrasting environments and/or different genetic backgrounds, suggesting that environmental variability and genetic background did not have a detectable impact on the action of the genes or genomic regions underlying these QTL, while other QTLs detected only in one of the environments are possibly under strong environmental interaction. These novel results are relevant, given that they provide target regions for marker assisted selection within families and starting point for association genetics studies.
No primeiro capítulo desta tese, foi desenvolvido e geneticamente mapeado um novo conjunto de microssatélites para Eucalyptus spp. derivados de EST (Expressed Sequence Tag). Foi feita uma triagem de 232 microssatélites derivados de EST utilizando-se um painel de 12 indivíduos correspondendo aos parentais das populações segregantes do projeto Genolyptus. Dentre os locos amplificados com sucesso, 78% foram polimórficos e apresentaram um nível elevado de transferibilidade interespecífica. Trinta e seis locos foram selecionados para mapeamento com base no tamanho dos segmentos amplificados (< 400 pb), motivos de repetição e BLAST positivo com genes de interesse em bancos públicos de dados. Com o objetivo de mapeamento, os 36 locos foram avaliados quanto ao polimorfismo e a segregação em uma população de referência envolvendo os parentais E. grandis x E. urophylla, verificando-se que a quantidade de locos totalmente informativos foi cerca de 40% menor quando comparados com microssatélites derivados de bibliotecas genômicas enriquecidas. Apesar da menor hipervariabilidade estes locos são interessantes para mapeamento, pois correspondem a regiões gênicas, possibilitando mapeamento comparativo e potencial colocalização de genes com QTLs. Dos locos em configuração informativa de segregação, 20 foram mapeados com sucesso. Estes locos mapeados foram caracterizados quanto ao seu conteúdo de informação para análise genética. Embora os microssatélites derivados de EST sejam menos polimórficos que os microssatélites derivados de sequências não codificantes, ainda assim eles podem ser utilizados com eficiência na discriminação de indivíduos, estudos de parentesco, avaliação de diversidade genética, mapeamento genético e seleção assistida por marcadores. O segundo capítulo teve como objetivo a verificação da coincidência de detecção de QTLs por meio da comparação da posição genômica e magnitude de efeito de QTLs para características silviculturais de crescimento e de qualidade da madeira em amostras de descendentes de três famílias segregantes de Eucalyptus spp. em dois locais experimentais contrastantes (Guanhães- MG e Guaíba- RS). As famílias estudadas foram: (E. camadulensis) x (E. urophilla x E. globulus), C1 x UGL, (E. dunii x E. grandis) x (E. urophilla x E. globulus), DG x U2, e (E. dunii x E. grandis) x (E. urophilla), DG x UGL. Primeiramente foram selecionados marcadores microssatélites flanqueantes e internos às regiões de QTL mapeados em experimentos anteriores para estas três famílias oriundas do ambiente de Guaíba-RS. Posteriormente mapeou-se estes marcadores utilizando-se diferentes indivíduos destas mesmas três famílias oriundos do ambiente de Guanhães-MG. Foram estudados QTLs para oito características quantitativas relacionadas com desempenho silvicultural e qualidade da madeira. Detectou-se dois QTLs (altura e profundidade de penetração do Pilodyn) em comum para os dois ambientes, no genitor UGL da família C1 x UGL; dois QTLs (teor de lignina e rendimento depurado) nos genitores DG e U2 respectivamente, do cruzamento DG x U2 e quatro QTLs (dois para diâmetro à altura do peito, um para altura e um para volume) no genitor UGL, do cruzamento DG x UGL, sendo que dois destes se colocalizaram com QTLs para características biologicamente correlacionadas (r > 0,8). Ainda, três QTLs (diâmetro à altura do peito, altura e profundidade de penetração do Pilodyn) localizados no grupo de ligação 6 do genitor UGL se mostraram estáveis entre os diferentes backgrounds genéticos e ambientes. Os resultados indicam que QTLs de maior efeito para características de qualidade da madeira são detectados em ambientes contrastantes e/ou entre diferentes backgrounds genéticos, sugerindo que a variabilidade ambiental e de background genético não teve impacto detectável sobre a expressão dos genes presentes nestes QTLs. Estes resultados inéditos para Eucalyptus são relevantes, pois fornecem regiões alvo interessantes para a seleção assistida dentro de famílias via seleção para QTLs ou ainda como ponto de partida para estudos de genética de associação.
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Ishakova, Gulmira. "On the use of Quasi-Maximum Likelihood Estimation and Indirect Method for Stochastic Volatility models." Thesis, Halmstad University, School of Information Science, Computer and Electrical Engineering (IDE), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-1641.
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Stochastic volatility models have been focus for research in recent years.
One interesting and important topic has been the estimation procedure.
For a given stochastic volatility model this project aims to compare two
methods of parameter estimation.
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Fitzsimmons, Deborah. "Quality of life in pancreatic cancer and chronic pancreatitis." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326844.
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Mihaljević, Renata. "Biometrical Analyses of Epistasis and the Relationship between Line per se and Testcross Performance of Agronomic Traits in Elite Populations of European Maize (Zea mays L.)." [S.l. : s.n.], 2005. http://nbn-resolving.de/urn:nbn:de:bsz:100-opus-1391.
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Hohenheim, Univ., Diss., 2005.Aus: Congruency of quantitative trait loci detected for agronomic traits in testcrosses of five populations of European maize.2004.Crop Sci. 44:114-124. and QTL correspondence between line per se and testcross performance for agronomic traits in four populations of European maize.Crop Sci. 45:114-122.
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Ytournel, Florence. "Déséquilibre de liaison et cartographie de QTL en population sélectionnée." Phd thesis, AgroParisTech, 2008. http://pastel.archives-ouvertes.fr/pastel-00003789.
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Par définition le déséquilibre de liaison (Linkage Disequilibrium, LD) décrit les associations préférentielles entre allèles de deux locus. Ce concept est devenu un outil indispensable pour la cartographie fine de locus quantitatifs (QTL), par l'identification de déséquilibres d'associations entre allèles à un locus marqueur (ou à un ensemble de locus marqueurs) et à un locus impliqué dans la variation d'un caractère quantitatif. La création et l'intensité du LD sont dépendantes des forces évolutives qui ont construit la population. Parmi ces forces, la dérive génétique et la sélection sont particulièrement actives dans les populations d'animaux de rente. Cette thèse a pour but d'étudier l'influence de la sélection sur la structure du déséquilibre de liaison autour d'un locus quantitatif, ainsi que son impact sur la précision de cartographie fine des QTL. Un logiciel de simulation de populations a été développé dans le cadre de la thèse. A partir d'une population en équilibre de liaison, il permet de générer du LD dans des générations dites historiques, grâce à différentes forces évolutives. La détection de QTL est appliquée aux générations suivantes, de généalogie connue. Pour ces dernières générations, les principaux dispositifs de détection de QTL de génétique animale sont décrits dans le simulateur. Les données exploitées dans cette thèse sont issues de ce logiciel. Le LD a été mesuré par le D' et le
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Masle, Stela. "Multistage QTL mapping strategy in an advanced backcross cattle population." Diss., [S.l.] : [s.n.], 2007. http://edoc.ub.uni-muenchen.de/archive/00007061.
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