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Journal articles on the topic 'Rest-activity circadian rhythms: daily activity level'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Zhou, Ke, Marios Constantinides, Daniele Quercia, and Sanja Šćepanović. "How Circadian Rhythms Extracted from Social Media Relate to Physical Activity and Sleep." Proceedings of the International AAAI Conference on Web and Social Media 17 (June 2, 2023): 948–59. http://dx.doi.org/10.1609/icwsm.v17i1.22202.

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Circadian rhythm has been linked to both physical and mental health at an individual level in prior research. Such a link at population level has been long hypothesized but has never been tested, largely because of lack of data. To partly fix this literature gap, we need: a dataset on population-level circadian rhythms, a dataset on population-level health conditions, and strong associations between these two partly independent sets. Recent work has shown that affect on social media data relates to population-level circadian rhythms. Building upon that work, we extracted five circadian rhythm

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Aubourg, Timothée, Jacques Demongeot, and Nicolas Vuillerme. "Gaining Insights Into the Estimation of the Circadian Rhythms of Social Activity in Older Adults From Their Telephone Call Activity With Statistical Learning: Observational Study." Journal of Medical Internet Research 23, no. 1 (2021): e22339. http://dx.doi.org/10.2196/22339.

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Background Understanding the social mechanisms of the circadian rhythms of activity represents a major issue in better managing the mechanisms of age-related diseases occurring over time in the elderly population. The automated analysis of call detail records (CDRs) provided by modern phone technologies can help meet such an objective. At this stage, however, whether and how the circadian rhythms of telephone call activity can be automatically and properly modeled in the elderly population remains to be established. Objective Our goal for this study is to address whether and how the circadian

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Aubourg, Timothée, Jacques Demongeot, and Nicolas Vuillerme. "Gaining Insights Into the Estimation of the Circadian Rhythms of Social Activity in Older Adults From Their Telephone Call Activity With Statistical Learning: Observational Study." Journal of Medical Internet Research 23, no. 1 (2021): e22339. http://dx.doi.org/10.2196/22339.

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Background Understanding the social mechanisms of the circadian rhythms of activity represents a major issue in better managing the mechanisms of age-related diseases occurring over time in the elderly population. The automated analysis of call detail records (CDRs) provided by modern phone technologies can help meet such an objective. At this stage, however, whether and how the circadian rhythms of telephone call activity can be automatically and properly modeled in the elderly population remains to be established. Objective Our goal for this study is to address whether and how the circadian

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Bebas, Piotr, Bronislaw Cymborowski, and Jadwiga M. Giebultowicz. "Circadian rhythm of acidification in insect vas deferens regulated by rhythmic expression of vacuolar H+-ATPase." Journal of Experimental Biology 205, no. 1 (2002): 37–44. http://dx.doi.org/10.1242/jeb.205.1.37.

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SUMMARY Recent studies have demonstrated that the peripheral tissues of vertebrates and invertebrates contain circadian clocks; however, little is known about their functions and the rhythmic outputs that they generate. To understand clock-controlled rhythms at the cellular level, we investigated a circadian clock located in the reproductive system of a male moth (the cotton leaf worm Spodoptera littoralis) that is essential for the production of fertile spermatozoa. Previous work has demonstrated that spermatozoa are released from the testes in a daily rhythm and are periodically stored in th

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Alós, Josep, Martina Martorell-Barceló, and Andrea Campos-Candela. "Repeatability of circadian behavioural variation revealed in free-ranging marine fish." Royal Society Open Science 4, no. 2 (2017): 160791. http://dx.doi.org/10.1098/rsos.160791.

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Repeatable between-individual differences in the behavioural manifestation of underlying circadian rhythms determine chronotypes in humans and terrestrial animals. Here, we have repeatedly measured three circadian behaviours, awakening time, rest onset and rest duration, in the free-ranging pearly razorfish, Xyrithchys novacula , facilitated by acoustic tracking technology and hidden Markov models. In addition, daily travelled distance, a standard measure of daily activity as fish personality trait, was repeatedly assessed using a State-Space Model. We have decomposed the variance of these fou

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Atanaskovic, Marko, Marko Nemet, Borislav Tapavicki, Milica Vasilic, Ivona Stanic-Hadzalic, and Enis Garipi. "Effects of circadian rhythm and daily physical activity on short-term heart rate variability in young healthy adults: A pilot study." Medical review 75, no. 9-10 (2022): 295–99. http://dx.doi.org/10.2298/mpns2210295a.

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Introduction. Heart rate variability is the leading non-invasive method used for assessing the activity of the autonomic nervous system. Investigation of the changes in the autonomic nervous system activity under the influence of circadian rhythm and daily physical activity can be beneficial to exercise at the best time of the day and at regular time intervals. Furthermore, it can be used to determine the optimal level of total daily physical activity. This study aimed to demonstrate the effects of circadian rhythm and daily physical activity on the autonomic nervous system at rest through sho

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Li, Jia-Da, Katherine J. Burton, Chengkang Zhang, Shuang-Bao Hu, and Qun-Yong Zhou. "Vasopressin receptor V1a regulates circadian rhythms of locomotor activity and expression of clock-controlled genes in the suprachiasmatic nuclei." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 296, no. 3 (2009): R824—R830. http://dx.doi.org/10.1152/ajpregu.90463.2008.

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The suprachiasmatic nuclei (SCN) serve as the principal circadian pacemakers that coordinate daily cycles of behavior and physiology for mammals. A network of transcriptional and translational feedback loops underlies the operating molecular mechanism for circadian oscillation within the SCN neurons. It remains unclear how timing information is transmitted from SCN neurons to eventually evoke circadian rhythms. Intercellular communication between the SCN and its target neurons is critical for the generation of coherent circadian rhythms. At the molecular level, neuropeptides encoded by clock-c

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Tracy, Eunjin, Brian Chin, H. Matthew Lehrer, et al. "0282 Behavioral–social rhythms and metabolic syndrome prevalence in retired night shift and day workers." SLEEP 46, Supplement_1 (2023): A125. http://dx.doi.org/10.1093/sleep/zsad077.0282.

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Abstract Introduction Disrupted sleep and circadian rhythms, such as those occurring during night shift work, are established cardiovascular disease (CVD) risk factors like hypertension, obesity, and insulin resistance. However, we do not know whether the effects of shift work on CVD risk factors persist into retirement. Conversely, regularity in behavioral-social rhythms – the systematic patterning or timing of daily routines like work/housework, sleeping, eating and social interactions – may keep endogenous circadian rhythms synchronized to the 24-hour day and reduce CVD risk. This study exa

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Ragozin, Oleg N., Irina A. Pogonysheva, Elena Yu Shalamova, Denis A. Pogonyshev, Elina R. Ragozina, and Victoria V. Postnikova. "Variability of Helioclimate Factors and Applicability to the Emergency Service Population of the Northern Region." Bulletin of Nizhnevartovsk State University, no. 4 (December 7, 2022): 89–97. http://dx.doi.org/10.36906/2311-4444/22-4/09.

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The purpose of this study was to study the influence of the variability of weather and heliophysical factors on the appeal to the Ambulance service for different groups of nosologies in the population of the Russian North. Information about calls to the emergency medical service of Khanty-Mansiysk was obtained from the database of calls for the period from 2001 to 2021 by disease classes (ICD-10). To assess the dynamics of weather factors, data from the All-Russian Research Institute of Hydrometeorological Information and materials from the weather station of Khanty-Mansiysk were used. The dyn

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Tyutenova, Alima, Lyazzat Gumarova, Christian Cajochen, Manshuk Kamalova, and Yeskendyr Ashimov. "Influence of different light intensities during the day on the motor activity in adolescents." BIO Web of Conferences 100 (2024): 01018. http://dx.doi.org/10.1051/bioconf/202410001018.

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This study investigates the impact of varying light intensities throughout the day on motor activity levels in adolescent girls aged between 14-16, who are students at a boarding school. The study lasted for three weeks, with each week consisting of four days. During this period, participants experienced three different lighting conditions from 07:00 to 18:00. These conditions included: standard light intensity in real-life settings, wearing blue-blocking glasses, and spending at least 1.5 hours outdoors daily for natural light exposure. The aim was to understand how modern lighting sources ca

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Hsieh, Wan-Hsin, Carolina Escobar, Tatiana Yugay, et al. "Simulated shift work in rats perturbs multiscale regulation of locomotor activity." Journal of The Royal Society Interface 11, no. 96 (2014): 20140318. http://dx.doi.org/10.1098/rsif.2014.0318.

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Motor activity possesses a multiscale regulation that is characterized by fractal activity fluctuations with similar structure across a wide range of timescales spanning minutes to hours. Fractal activity patterns are disturbed in animals after ablating the master circadian pacemaker (suprachiasmatic nucleus, SCN) and in humans with SCN dysfunction as occurs with aging and in dementia, suggesting the crucial role of the circadian system in the multiscale activity regulation. We hypothesized that the normal synchronization between behavioural cycles and the SCN-generated circadian rhythms is re

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Huffeldt, Nicholas Per, and Flemming R. Merkel. "Sex-specific, inverted rhythms of breeding-site attendance in an Arctic seabird." Biology Letters 12, no. 9 (2016): 20160289. http://dx.doi.org/10.1098/rsbl.2016.0289.

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In contrast to daily rhythms that are common in the presence of the geophysical light–dark cycle, organisms at polar latitudes exhibit many diel activity patterns during natural periods of continuous solar light or darkness (polar day and night, respectively), from 24 h rhythms to arrhythmicity. In Arctic Greenland (73.7° N, 56.6° W) during polar day, we observed breeding-site attendance rhythms of thick-billed murres ( Uria lomvia ; n = 21 pairs), a charadriiform seabird, which provide biparental care at the colony. We found that U. lomvia egg-incubation and chick-brooding attendance is rhyth

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Cenek, Lisa, Liubou Klindziuk, Cindy Lopez, et al. "CIRCADA: Shiny Apps for Exploration of Experimental and Synthetic Circadian Time Series with an Educational Emphasis." Journal of Biological Rhythms 35, no. 2 (2020): 214–22. http://dx.doi.org/10.1177/0748730419900866.

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Circadian rhythms are daily oscillations in physiology and behavior that can be assessed by recording body temperature, locomotor activity, or bioluminescent reporters, among other measures. These different types of data can vary greatly in waveform, noise characteristics, typical sampling rate, and length of recording. We developed 2 Shiny apps for exploration of these data, enabling visualization and analysis of circadian parameters such as period and phase. Methods include the discrete wavelet transform, sine fitting, the Lomb-Scargle periodogram, autocorrelation, and maximum entropy spectr

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Caster, Stephen Z., Kathrina Castillo, Matthew S. Sachs, and Deborah Bell-Pedersen. "Circadian clock regulation of mRNA translation through eukaryotic elongation factor eEF-2." Proceedings of the National Academy of Sciences 113, no. 34 (2016): 9605–10. http://dx.doi.org/10.1073/pnas.1525268113.

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The circadian clock has a profound effect on gene regulation, controlling rhythmic transcript accumulation for up to half of expressed genes in eukaryotes. Evidence also exists for clock control of mRNA translation, but the extent and mechanisms for this regulation are not known. In Neurospora crassa, the circadian clock generates daily rhythms in the activation of conserved mitogen-activated protein kinase (MAPK) pathways when cells are grown in constant conditions, including rhythmic activation of the well-characterized p38 osmosensing (OS) MAPK pathway. Rhythmic phosphorylation of the MAPK

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Romanchuk, N., and V. Pyatin. "Melatonin: Neurophysiological and Neuroendocrine Aspects." Bulletin of Science and Practice 5, no. 7 (2019): 71–85. https://doi.org/10.33619/2414-2948/44/08.

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Optimization of neurobiological and chronomedicine processes possible with the development of circadian melatonin and ensuring its long-term concentration in the human body. Individual combined (drug and non-drug) intervention in the circadian axis ‘microbiota–intestine–brain’ with the help of daily consumption of functional foods, has a positive effect on cognitive and mental health. Introduction of research results N. P. Romanchuk (2010, 2013, 2016, 2017), it allows you to restore the functioning of the circadian system of man, normalize the level and concentration of

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Yang, Hui-Wen, Mirjam Münch, Ma Cherrysse Ulsa, et al. "Fractal biomarker of daily activity for women with early onset depression." BMJ Mental Health 28, no. 1 (2025): e301321. https://doi.org/10.1136/bmjment-2024-301321.

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BackgroundDepression is a major health issue in adolescence and young adulthood, emphasising the need for early risk identification. Patients with major depressive disorder (MDD) often show disturbed daily rest-activity patterns, but such changes are often confounded by medication intake, comorbidities and disease duration.ObjectiveIn this exploratory analysis, we tested whether there are specific changes in daily rest activity (from wrist-worn actigraphy) in women at the onset of MDD without medication, as compared with age-matched controls.MethodsParticipants from the MDD group (age 19–32, 2

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Karavanskyi, Yu V., I. L. Ryzhko, and V. V. Zamorov. "CIRCADE RHYTHMS OF PINCHUK'S GOBY PONTICOLA CEPHALARGOIDES (PINCHUK, 1976) IN LABORATORY CONDITIONS." Odesa National University Herald. Biology 26, no. 2(49) (2021): 37–47. http://dx.doi.org/10.18524/2077-1746.2021.2(49).246881.

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Introduction. Circadian rhythms help the body to anticipate changes in environmental conditions and adapt to the daily fluctuations of external factors. The presence of such mechanisms, which provide early preparation of the organism, gives an advantage in the struggle for survival. The dynamics of light is one of the main factors, which determines the level of growth, development, nutrition, metabolism, affects hormonal activity. Aim. The aim of the study was to study the circadian rhythms of motor activity of Pinchuk's goby Ponticola cephalargoides (Pinchuk, 1976) in the laboratory. Methods.

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Herzog, Erik D., and Rachel M. Huckfeldt. "Circadian Entrainment to Temperature, But Not Light, in the Isolated Suprachiasmatic Nucleus." Journal of Neurophysiology 90, no. 2 (2003): 763–70. http://dx.doi.org/10.1152/jn.00129.2003.

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The suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian rhythms in mammalian physiology and behavior. The abilities to synchronize to daily cycles in the environment and to keep accurate time over a range of physiologic temperatures are two fundamental properties of circadian pacemakers. Recordings from a bioluminescent reporter ( Per1-luc) of Period1 gene activity in rats showed that the cultured SCN entrained to daily, 1.5°C cycles of temperature, but did not synchronize to daily light cycles. Temperature entrainment developed by 1 day after birth. Light cycles failed

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Siehler, Oliver, Shuo Wang, and Guy Bloch. "Social synchronization of circadian rhythms with a focus on honeybees." Philosophical Transactions of the Royal Society B: Biological Sciences 376, no. 1835 (2021): 20200342. http://dx.doi.org/10.1098/rstb.2020.0342.

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Many animals benefit from synchronizing their daily activities with conspecifics. In this hybrid paper, we first review recent literature supporting and extending earlier evidence for a lack of clear relationship between the level of sociality and social entrainment of circadian rhythms. Social entrainment is specifically potent in social animals that live in constant environments in which some or all individuals do not experience the ambient day-night cycles. We next focus on highly social honeybees in which there is good evidence that social cues entrain the circadian clocks of nest bees and

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Jasinska, Malgorzata, Anna Grzegorczyk, Ewa Jasek, et al. "Daily rhythm of synapse turnover in mouse somatosensory cortex." Acta Neurobiologiae Experimentalis 74, no. 1 (2014): 104–10. http://dx.doi.org/10.55782/ane-2014-1977.

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The whisker representations in the somatosensory barrel cortex of mice are modulated by sensory inputs associated with animal motor behavior which shows circadian rhythmicity. In a C57/BL mouse strain kept under a light/dark (LD 12:12) regime, we observed daily structural changes in the barrel cortex, correlated with the locomotor activity level. Stereological analysis of serial electron microscopic sections of the barrel cortex of mice sacrificed during their active or rest period, revealed an increase in the total numerical density of synapses and in the density of excitatory synapses locate

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Cox, Rebecca, Sophie Haller, Zofia Martinez-Lisowska, et al. "0677 Blunted daily light rhythm amplitude in adults with opioid use disorder (OUD)." SLEEP 46, Supplement_1 (2023): A297—A298. http://dx.doi.org/10.1093/sleep/zsad077.0677.

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Abstract Introduction Accumulating evidence implicates sleep and circadian rhythm disruption in substance use disorders, including opioid use disorder (OUD). Blunted amplitude in daily rhythms of circadian-relevant variables (e.g., activity, light) may be a marker of psychopathology, as depressed adults demonstrate a smaller activity amplitude compared with healthy controls. The present study compared the light and activity amplitudes of adults with OUD with healthy controls. Methods Light and activity data were collected from adults with OUD who were recently stabilized on medication-assisted

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Perebetyuk, L. S., L. V. Moroz, S. V. Shevchuk, Y. S. Segeda та O. E. Shtatko. "Daily interleukin-1β variability in women with rheumatoid arthritis associated with fibromyalgia". Reports of Vinnytsia National Medical University 23, № 4 (2019): 616–20. http://dx.doi.org/10.31393/reports-vnmedical-2019-23(4)-10.

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Annotation. Disorders of circadian rhythms are considered to be one of the factors associated with the development of joint diseases. In patients with rheumatoid arthritis (RA) disorders of the neurohumoral regulation of circadian rhythms is a factor in the increased production of inflammatory cytokines in the joint tissues. In 30 % of RA patients, concomitant fibromyalgia (FM) is found, in which disorders of circadian regulation can deepen. Circadian features of the production of pain mediators and inflammation in RA patients with comorbid fibromyalgia (FM) have not been established. The aim

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Barnea, Maayan, Zecharia Madar, and Oren Froy. "High-Fat Diet Delays and Fasting Advances the Circadian Expression of Adiponectin Signaling Components in Mouse Liver." Endocrinology 150, no. 1 (2008): 161–68. http://dx.doi.org/10.1210/en.2008-0944.

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The circadian clock controls energy homeostasis by regulating circadian expression and/or activity of enzymes involved in metabolism. Disruption of circadian rhythms may lead to obesity and metabolic disorders. We tested whether the biological clock controls adiponectin signaling pathway in the liver and whether fasting and/or high-fat (HF) diet affects this control. Mice were fed low-fat or HF diet and fasted on the last day. The circadian expression of clock genes and components of adiponectin metabolic pathway in the liver was tested at the RNA, protein, or enzyme activity level. In additio

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Evans, Jennifer A., Tanya L. Leise, Oscar Castanon-Cervantes, and Alec J. Davidson. "Neural correlates of individual differences in circadian behaviour." Proceedings of the Royal Society B: Biological Sciences 282, no. 1810 (2015): 20150769. http://dx.doi.org/10.1098/rspb.2015.0769.

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Daily rhythms in mammals are controlled by the circadian system, which is a collection of biological clocks regulated by a central pacemaker within the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. Changes in SCN function have pronounced consequences for behaviour and physiology; however, few studies have examined whether individual differences in circadian behaviour reflect changes in SCN function. Here, PERIOD2::LUCIFERASE mice were exposed to a behavioural assay to characterize individual differences in baseline entrainment, rate of re-entrainment and free-running rhythms. SCN

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Shavlakadze, T., T. Anwari, Z. Soffe, et al. "Impact of fasting on the rhythmic expression of myogenic and metabolic factors in skeletal muscle of adult mice." American Journal of Physiology-Cell Physiology 305, no. 1 (2013): C26—C35. http://dx.doi.org/10.1152/ajpcell.00027.2013.

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Circadian rhythms and metabolism are tightly integrated, and rhythmic expression of metabolic factors is common in homeostatic processes. We measured the temporal changes in the expression of myogenic regulatory factors and expression and activity level of molecules involved in protein metabolism in skeletal muscles and livers in mice and examined the impact of fasting. Tissues were collected over 24 h (at zeitgeber times ZT1, ZT5, ZT9, ZT13, ZT17, ZT21, and ZT1 the following day) from adult male C57Bl/6J mice that had been either freely fed or fasted for 24 h. In skeletal muscle, there was a

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Flôres, Danilo E. F. L., and Gisele A. Oda. "Quantitative Study of Dual Circadian Oscillator Models under Different Skeleton Photoperiods." Journal of Biological Rhythms 35, no. 3 (2020): 302–16. http://dx.doi.org/10.1177/0748730420901939.

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The daily proportion of light and dark hours (photoperiod) changes annually and plays an important role in the synchronization of seasonal biological phenomena, such as reproduction, hibernation, and migration. In mammals, the first step of photoperiod transduction occurs in the suprachiasmatic nuclei (SCN), the circadian pacemaker that also coordinates 24-h activity rhythms. Thus, in parallel with its role in annual synchronization, photoperiod variation acutely shapes day/night activity patterns, which vary throughout the year. Systematic studies of this behavioral modulation help understand

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Huang, T., J. Chung, M. Reid, et al. "1007 Sociodemographic, Lifestyle and Dietary Correlates of Actigraphy-Measured Irregular Sleep Schedules in the Multi-Ethnic Study of Atherosclerosis." Sleep 43, Supplement_1 (2020): A382—A383. http://dx.doi.org/10.1093/sleep/zsaa056.1003.

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Abstract Introduction Increasing evidence links daily variability in sleep schedules to increased cardiometabolic risk. Little is known, however, regarding sociodemographic and behavioral correlates of irregular sleep schedules that may help identify causes or consequences of irregular sleep. Methods Among 1,946 participants from the Multi-Ethnic Study of Atherosclerosis, we examined the cross-sectional associations of irregular sleep schedules with sociodemographic, lifestyle, dietary factors, and actigraphy-based indices of rest-wake rhythms using multiple linear regression with adjustment f

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Yang, Hui-Wen, Marta Garaulet, Peng Li, et al. "Daily Rhythm of Fractal Cardiac Dynamics Links to Weight Loss Resistance: Interaction with CLOCK 3111T/C Genetic Variant." Nutrients 13, no. 7 (2021): 2463. http://dx.doi.org/10.3390/nu13072463.

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The effectiveness of weight loss treatment displays dramatic inter-individual variabilities, even with well-controlled energy intake/expenditure. This study aimed to determine the association between daily rhythms of cardiac autonomic control and weight loss efficiency and to explore the potential relevance to weight loss resistance in humans carrying the genetic variant C at CLOCK 3111T/C. A total of 39 overweight/obese Caucasian women (20 CLOCK 3111C carriers and 19 non-carriers) completed a behaviour–dietary obesity treatment of ~20 weeks, during which body weight was assessed weekly. Ambul

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Hor, Charlotte N., Jake Yeung, Maxime Jan, et al. "Sleep–wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex." Proceedings of the National Academy of Sciences 116, no. 51 (2019): 25773–83. http://dx.doi.org/10.1073/pnas.1910590116.

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The timing and duration of sleep results from the interaction between a homeostatic sleep–wake-driven process and a periodic circadian process, and involves changes in gene regulation and expression. Unraveling the contributions of both processes and their interaction to transcriptional and epigenomic regulatory dynamics requires sampling over time under conditions of unperturbed and perturbed sleep. We profiled mRNA expression and chromatin accessibility in the cerebral cortex of mice over a 3-d period, including a 6-h sleep deprivation (SD) on day 2. We used mathematical modeling to integrat

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Sundar, Isaac K., Hongwei Yao, Michael T. Sellix, and Irfan Rahman. "Circadian molecular clock in lung pathophysiology." American Journal of Physiology-Lung Cellular and Molecular Physiology 309, no. 10 (2015): L1056—L1075. http://dx.doi.org/10.1152/ajplung.00152.2015.

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Disrupted daily or circadian rhythms of lung function and inflammatory responses are common features of chronic airway diseases. At the molecular level these circadian rhythms depend on the activity of an autoregulatory feedback loop oscillator of clock gene transcription factors, including the BMAL1:CLOCK activator complex and the repressors PERIOD and CRYPTOCHROME. The key nuclear receptors and transcription factors REV-ERBα and RORα regulate Bmal1 expression and provide stability to the oscillator. Circadian clock dysfunction is implicated in both immune and inflammatory responses to enviro

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Lim, Ji Ye, Eunju Kim, Collin M. Douglas, et al. "The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling." PLOS Genetics 18, no. 12 (2022): e1010574. http://dx.doi.org/10.1371/journal.pgen.1010574.

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Numerous molecular and physiological processes in the skeletal muscle undergo circadian time-dependent oscillations in accordance with daily activity/rest cycles. The circadian regulatory mechanisms underlying these cyclic processes, especially at the post-transcriptional level, are not well defined. Previously, we reported that the circadian E3 ligase FBXL21 mediates rhythmic degradation of the sarcomere protein TCAP in conjunction with GSK-3β, and Psttm mice harboring an Fbxl21 hypomorph allele show reduced muscle fiber diameter and impaired muscle function. To further elucidate the regulato

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Cannizzaro, Emanuele, Luigi Cirrincione, Walter Mazzucco, et al. "Night-Time Shift Work and Related Stress Responses: A Study on Security Guards." International Journal of Environmental Research and Public Health 17, no. 2 (2020): 562. http://dx.doi.org/10.3390/ijerph17020562.

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Work-related stress can induce a break in homeostasis by placing demands on the body that are met by the activation of two different systems, the hypothalamic–pituitary–adrenal axis and the sympathetic nervous system. Night-shift work alters the body’s exposure to the natural light–dark schedule and disrupts circadian (daily) rhythms. The greatest effect of night-shift work is the disruption of circadian rhythms. The impact that these disruptions may have on the pathogenesis of many diseases, including cancer, is unknown. This study aims to discover the relationship among three different job a

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Chen, Hung-Hsun, Chen Lin, Hsiang-Chih Chang, Jen-Ho Chang, Hai-Hua Chuang, and Yu-Hsuan Lin. "Developing Methods for Assessing Mental Activity Using Human-Smartphone Interactions: Comparative Analysis of Activity Levels and Phase Patterns in General Mental Activities, Working Mental Activities, and Physical Activities." Journal of Medical Internet Research 26 (June 17, 2024): e56144. http://dx.doi.org/10.2196/56144.

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Background Human biological rhythms are commonly assessed through physical activity (PA) measurement, but mental activity may offer a more substantial reflection of human biological rhythms. Objective This study proposes a novel approach based on human-smartphone interaction to compute mental activity, encompassing general mental activity (GMA) and working mental activity (WMA). Methods A total of 24 health care professionals participated, wearing wrist actigraphy devices and using the “Staff Hours” app for more than 457 person-days, including 332 workdays and 125 nonworkdays. PA was measured

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Nechitaylo, Yuriy, Oleksandr Buriak, Olesya Pidmurniak, Nataliya Kovtyuk, and Tatiana Fomina. "VARIABILITY OF ARTERIAL BLOOD PRESSURE IN CHILDREN WITH DIABETES MELLITUS AND OBESITY." CBU International Conference Proceedings 7 (September 30, 2019): 778–82. http://dx.doi.org/10.12955/cbup.v7.1454.

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INTRODUCTION: The activity of the cardiovascular system has a clear to the circadian rhythms of a child's body. Daily fluctuations in blood pressure in normal conditions and in pathology is a physiological phenomenon which can play a significant role in developing arterial hypertension and even in the occurrence of fatal cardiovascular states such as heart attacks, strokes, and sudden cardiac arrest activities. Ambulatory blood pressure monitoring is recognized as a necessary instrumental investigation for diagnosis and management of patients with arterial hypertension and especially in childr

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Denisovets, T., O. Kvak, and V. Gogots. "FEATURES OF THE INFLUENCE OF BIORHYTHMS ON THE STATE OF BIOCHEMICAL PROCESSES IN THE HUMAN ORGANISM." Ukrainian professional education, no. 14 (December 29, 2023): 149–57. http://dx.doi.org/10.33989/2519-8254.2023.14.300243.

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The article examines and theoretically analyzes human biological rhythms, which closely interact with the environment and respond to all circadian processes existing in the body. It has been proven that the vital activity of biological systems, their metabolism, the intensity of changes in physiological biorhythms is directly dependent on external (exogenous) and internal (endogenous) factors. The biological rhythms of the body and their impact on human performance have been determined. Depending on the daily biorhythms, certain changes occur in the body, both in the internal environment

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Yulia, Nisa, Dony Ardianto, Mustika Ratnaningsih Purbowati, and Resa Budi Deskianditya. "The Relationship Between Insomnia And Fitness Level In Medical Faculty Students Of Universitas Muhammadiyah Purwokerto." Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan 6, no. 2 (2024): 16. http://dx.doi.org/10.30595/hmj.v6i2.19878.

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Physical fitness is a condition in which a person can carry out daily activities in a healthy and fit condition without quickly experiencing fatigue. Several factors can affect fitness level, such as a decrease in the hormone melatonin caused by insomnia. It will affect circadian rhythms and reduce a person's physical activity, thus affecting fitness level. To observe the relationship between insomnia and fitness level in Medical Faculty students of Universitas Muhammadiyah Purwokerto. This study used a cross-sectional analytic observational study design. Primary data was obtained from the res

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Bulyk, R. Y., A. V. Abramov, T. S. Bulyk, M. I. Kryvchanska, and K. V. Vlasova. "The effects of melatonin on the activity of the c-fos gene in the structures of the hypothalamic paraventricular nucleus under prolonged lighting." Regulatory Mechanisms in Biosystems 9, no. 2 (2018): 131–34. http://dx.doi.org/10.15421/021819.

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The effect of constant illumination as a stress factor on the state of the "early response" c-fos gene in the lateral magnocellular subnuclei of the paraventricular nucleus (lmPVN) of the hypothalamus of rats at different time intervals (day and night) has been studied. To identify c-Fos in histological sections of the hypothalamus, a secondary (indirect) immunofluorescence method is used. Expression of the product of this gene, the c-Fos protein, in animals kept under normal conditions of alternation of illumination and darkness, shows a clear-cut circadian character. There was a significant

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Yang, Hui-Wen, Peng Li, Haoqi Sun, et al. "0195 Integrated actigraphy-based biomarker for the risk of Alzheimer’s dementia." Sleep 45, Supplement_1 (2022): A89. http://dx.doi.org/10.1093/sleep/zsac079.193.

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Abstract Introduction Many physiological measures derived from actigraphy including physical activity, sleep, circadian/daily rhythm, and temporal correlations have been shown to predict Alzheimer’s dementia (AD). This study aimed to combine these actigraphy-based measures to develop an integrated actigraphy biomarker (IAB) for AD and to test its link to the genetic risk for AD. Methods We analyzed data of 1107 participants (age 80.9±7.3(mean±SD)) from the Rush Memory and Aging Project who were non-demented and had actigraphy (~10 days) at baseline, and had annual cognitive assessment during t

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Zaichko, K., M. Stanislavchuk, N. Zaichko та V. Khomenko. "FRI0025 CIRCADIAN RHYTHMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE PRODUCTION IN FEMALES WITH RHEUMATOID ARTHRITIS AND ARTERIAL HYPERTENSION DEPENDING ON NOS3 Т786С GENE POLYMORPHISM". Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 585.2–585. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4254.

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Background:One of the most common comorbidity in patients with rheumatoid arthritis (RA) is arterial hypertension (AH), with incidence ranging from 20 to 60%. Mechanisms of this comorbidity arises a lot of interest. In our previous study was established the association ofT786C NOS3(rs2070744) gene polymorphism with AH in females with RA in the Ukrainian population [1].Objectives:So next, we were aiming to investigate daily fluctuation of endothelial nitric oxide synthase (NOS3) in RA patients with AH depending onNOS3 T786Cgene polymorphism.Methods:In the study were enrolled 173 females with RA

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Yalçin, Müge, Ana Rita Peralta, Carla Bentes, et al. "Molecular characterization of the circadian clock in patients with Parkinson’s disease–CLOCK4PD Study protocol." PLOS ONE 19, no. 7 (2024): e0305712. http://dx.doi.org/10.1371/journal.pone.0305712.

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Introduction Circadian rhythms (CRs) orchestrate intrinsic 24-hour oscillations which synchronize an organism’s physiology and behaviour with respect to daily cycles. CR disruptions have been linked to Parkinson’s Disease (PD), the second most prevalent neurodegenerative disorder globally, and are associated to several PD-symptoms such as sleep disturbances. Studying molecular changes of CR offers a potential avenue for unravelling novel insights into the PD progression, symptoms, and can be further used for optimization of treatment strategies. Yet, a comprehensive characterization of the alt

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Zaichko, K., and N. Zaichko. "POS0622 ASSOCIATION OF DIURNAL FLUCTUATION OF THE SOLUBLE TOLL-LIKE RECEPTORS 2 (sTLR2) WITH COMORBIDITY AND QUALITY OF LIFE IN WOMEN WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 579.1–579. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3955.

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BackgroundDisorders of circadian rhythms in the production of inflammatory mediators play an important role in the pathogenesis of rheumatoid arthritis (RA) [1]. Innate immune factors, in particular toll-like receptors 2 (TLR2), are involved in the formation of the inflammatory pattern in RA. Recently was shown that TLR2 play an important role in the development of atherosclerosis and hypertension [2]. Chronobiological aspects of innate immunity, in particular circadian rhythms of the soluble form of TLR2 (sTLR2) in RA and its comorbidity, requires further study.ObjectivesThe aim of the study

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Nechytailo, D., T. Mikheeva, and O. Hodovanets. "CHRONOBIOLOGICAL ASPECTS OF ARTERIAL PRESSURE LEVEL IN SCHOOLCHILDREN WITH ARTERIAL PREHYPERTENSION." Neonatology, surgery and perinatal medicine 12, no. 1(43) (2022): 37–42. http://dx.doi.org/10.24061/2413-4260.xii.1.43.2022.7.

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Introduction. Arterial pressure has significant diurnal fluctuations, reaching its minimum and maximum values at certain hours of the day. For a complete characterization of arterial hypertension in recent years, the method of daily monitoring of arterial pressure is most often used, which makes it possible to determine the forms of the disease (labile and stable), circadian rhythms of arterial pressure and its variability. The use of this method in children may be even more important than in adults.Aim: to evaluate the chronobiological aspects of the level of arterial pressure in schoolchildr

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Chaibub Neto, Elias, Thanneer M. Perumal, Abhishek Pratap, et al. "Disentangling personalized treatment effects from “time-of-the-day” confounding in mobile health studies." PLOS ONE 17, no. 8 (2022): e0271766. http://dx.doi.org/10.1371/journal.pone.0271766.

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Ideally, a patient’s response to medication can be monitored by measuring changes in performance of some activity. In observational studies, however, any detected association between treatment (“on-medication” vs “off-medication”) and the outcome (performance in the activity) might be due to confounders. In particular, causal inferences at the personalized level are especially vulnerable to confounding effects that arise in a cyclic fashion. For quick acting medications, effects can be confounded by circadian rhythms and daily routines. Using the time-of-the-day as a surrogate for these confou

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Fujioka, Haruna, Masato S. Abe, and Yasukazu Okada. "Individual Ants Do Not Show Activity-Rest Rhythms in Nest Conditions." Journal of Biological Rhythms 36, no. 3 (2021): 297–310. http://dx.doi.org/10.1177/07487304211002934.

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Circadian rhythms, which respond to the day-night cycle on the earth, arise from the endogenous timekeeping system within organisms, called the “biological clock.” For accurate circadian rhythms, daily fluctuations in light and temperature are considered one of the important time cues. In social insects, both abiotic and biotic factors (i.e., social interactions) play a significant role in activity-rest rhythm regulation. However, it is challenging to monitor individual activity-rest rhythms in a colony because of the large group size and small body size. Therefore, it is unclear whether indiv

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Potapova, E. A., D. A. Zemlyanoy, V. P. Ilyichev, I. V. Vasilyeva, E. A. Svintsitskaya, and A. V. Ivanov. "Eating behavior and psychoemotional state of adolescents living in regions with different daylight hours." Sanitarnyj vrač (Sanitary Doctor), no. 7 (June 29, 2025): 523–33. https://doi.org/10.33920/med-08-2507-03.

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This study examined the relationship between the light climate, eating behavior, and the psychoemotional state of adolescents living in regions with different daylight hours (Voronezh, Murmansk, and St. Petersburg). The sample included 180 adolescents aged 14–18 years. The work uses a comprehensive methodological approach that includes standardized psychodiagnostic tools (the Yale YFAS Food Addiction Scale, the Tsung Depression Scale, the PedsQL™ questionnaire) and an author’s questionnaire to assess the daily routine. The results revealed statistically significant regional differences in the

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Slyepchenko, Anastasiya, Olivia R. Allega, Xiamin Leng, et al. "Association of functioning and quality of life with objective and subjective measures of sleep and biological rhythms in major depressive and bipolar disorder." Australian & New Zealand Journal of Psychiatry 53, no. 7 (2019): 683–96. http://dx.doi.org/10.1177/0004867419829228.

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Objective: Disruptions in biological rhythms and sleep are a core aspect of mood disorders, with sleep and rhythm changes frequently occurring prior to and during mood episodes. Wrist-worn actigraphs are increasingly utilized to measure ambulatory activity rhythm and sleep patterns. Methods: A comprehensive study using subjective and objective measures of sleep and biological rhythms was conducted in 111 participants (40 healthy volunteers [HC], 38 with major depressive disorder [MDD] and 33 with bipolar disorder [BD]). Participants completed 15-day actigraphy and first-morning urine samples t

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Brüning, Franziska, Sara B. Noya, Tanja Bange, et al. "Sleep-wake cycles drive daily dynamics of synaptic phosphorylation." Science 366, no. 6462 (2019): eaav3617. http://dx.doi.org/10.1126/science.aav3617.

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The circadian clock drives daily changes of physiology, including sleep-wake cycles, through regulation of transcription, protein abundance, and function. Circadian phosphorylation controls cellular processes in peripheral organs, but little is known about its role in brain function and synaptic activity. We applied advanced quantitative phosphoproteomics to mouse forebrain synaptoneurosomes isolated across 24 hours, accurately quantifying almost 8000 phosphopeptides. Half of the synaptic phosphoproteins, including numerous kinases, had large-amplitude rhythms peaking at rest-activity and acti

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Ingram, Krista K., Deborah M. Gordon, Daniel A. Friedman, Michael Greene, John Kahler, and Swetha Peteru. "Context-dependent expression of the foraging gene in field colonies of ants: the interacting roles of age, environment and task." Proceedings of the Royal Society B: Biological Sciences 283, no. 1837 (2016): 20160841. http://dx.doi.org/10.1098/rspb.2016.0841.

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Task allocation among social insect workers is an ideal framework for studying the molecular mechanisms underlying behavioural plasticity because workers of similar genotype adopt different behavioural phenotypes. Elegant laboratory studies have pioneered this effort, but field studies involving the genetic regulation of task allocation are rare. Here, we investigate the expression of the foraging gene in harvester ant workers from five age- and task-related groups in a natural population, and we experimentally test how exposure to light affects foraging expression in brood workers and forager

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Helfrich-Förster, Charlotte, Michael N. Nitabach, and Todd C. Holmes. "Insect circadian clock outputs." Essays in Biochemistry 49 (June 30, 2011): 87–101. http://dx.doi.org/10.1042/bse0490087.

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Insects display an impressive variety of daily rhythms, which are most evident in their behaviour. Circadian timekeeping systems that generate these daily rhythms of physiology and behaviour all involve three interacting elements: the timekeeper itself (i.e. the clock), inputs to the clock through which it entrains and otherwise responds to environmental cues such as light and temperature, and outputs from the clock through which it imposes daily rhythms on various physiological and behavioural parameters. In insects, as in other animals, cellular clocks are embodied in clock neurons capable o

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Hoopes, Elissa, Michele D'Agata, Talia Brookstein-Burke, et al. "0003 On the Same Wavelength? Quantifying the Associations between Eating Timing and Rest-Activity Rhythms in Free-Living Adults." Sleep 45, Supplement_1 (2022): A1—A2. http://dx.doi.org/10.1093/sleep/zsac079.002.

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Abstract Introduction Misalignment between the central circadian clock and daily behaviors increases cardiometabolic morbidity and mortality risk, likely due to internal misalignment between central and peripheral circadian rhythms. Experimental studies suggest food intake may act as a time cue (‘zeitgeber’) for resetting circadian rhythms, representing a potential behavioral target to ameliorate circadian misalignment and associated health consequences. However, the extent to which eating timing relates to circadian rhythms in free-living adults is unclear. Therefore, we tested the associatio

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