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Journal articles on the topic 'Reti Virtuali'
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Leonardi, Laura. "L’altra metà del ciberspazio. Donne e partecipazione sociale tra reti virtuali e reti convenzionali." Quaderni di Sociologia, no. 23 (August 1, 2000): 64–84. http://dx.doi.org/10.4000/qds.1362.
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Artusi, Marco, and Andrea Maurizzi. "Le nuove frontiere del marketing politico: Internet come strumento di costruzione e gestione del consenso." MERCATI & COMPETITIVITÀ, no. 3 (September 2010): 75–96. http://dx.doi.org/10.3280/mc2010-003007.
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Questo articolo si concentra sulle applicazioni digitali nella comunicazione politica e nello sviluppo del consenso, partendo dal presupposto che sia necessario superare la concezione di Internet come semplice mezzo di comunicazione di massa, ma che que- sto vada analizzato come strumento sociale di acquisizione, attivazione e coinvolgimento di persone attorno ad un movimento o idea politica. Le evoluzioni in senso sociale in atto nella Rete Internet stanno portando ad un'integrazione tra reale e virtuale, e stanno rendendo Internet una rappresentazione sempre piů fedele della realtÀ e delle reti sociali dei diversi soggetti: da qui nasce una grande opportunitÀ di costruzione del consenso. Sulla base di queste considerazioni, viene elaborato un modello di comunicazione politica in Internet, integrato nel processo di marketing politico ed articolato nelle fasi di acquisizione, attivazione e difesa. Il modello č basato sulla significativa esperienza di Barack Obama.
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Passerone, Francesca. "Navigatori o ragni pescatori?" STUDI JUNGHIANI, no. 35 (February 2013): 59–73. http://dx.doi.org/10.3280/jun2012-035004.
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L'articolo propone alcune riflessioni sull'influenza delle nuove tecnologie digitali sul modo di pensare, di conoscere e di comunicare. Il virtuale determina una consistente modificazione della qualitŕ della presenza, che si manifesta in nuovi modi di rappresentare la realtŕ e di entrare in relazione. L'Autrice paragona la Rete a una "mente collettiva" e si interroga sulle vicissitudini dei processi immaginativi individuali nell'era attuale. Particolare attenzione viene data alla peculiaritŕ delle relazioni che si instaurano attraverso Facebook e piů in generale alla comunicazione nell'era digitale, evidenziandone luci ed ombre. L'aspetto centrale messo in rilievo, specialmente rispetto all'emergere di nuove patologie, č l'assenza del corpo nelle relazioni virtuali. La capacitŕ di ritornare al corpo, di incarnare le esperienze vissute in Rete, determina quel momento riflessivo che si configura come essenziale per "fare anima". Solo attraverso l'integrazione fra mente e corpo possiamo esperire la Rete come un'immagine viva dell'inconscio collettivo che si dispiega nella contemporaneitŕ, donando forma e significato a ciň che sperimentiamo nella realtŕ virtuale.
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Origgi, Giancarlo. "Apprendimento." EDUCAZIONE SENTIMENTALE, no. 15 (December 2010): 19–25. http://dx.doi.org/10.3280/eds2011-015003.
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Il saggio tenta di dare forma alle tante dimensioni del concetto di apprendimento nella societŕ della conoscenza, in relazione alle tematiche del lifelong learning ed a quelle relative all'innovazione dei modelli di conoscenza e di formazione legati all'introduzione delle nuove tecnologie ed al ruolo, sempre piů significativo, che l'individuo assume all'interno della realtŕ virtuale. Un concetto fondamentale dell'articolo č il concetto di "rete" assunto come metafora essenziale capace di delineare la vita degli individui nella knowledge society. Il termine "rete" fa riferimento, in tal senso ed allo stesso tempo, a tanti concetti estremamente significativi della societŕ contemporanea e della vita degli individui: la rete designa al tempo stesso la conoscenza, la cittŕ, la societŕ, internet, la navigazione tra mondi reali e virtuali disegnati, dalle nuove tecnologie, nella formazione cosě come nel cinema, nella letteratura cosě come nelle discipline del costruttivismo. L'articolo si conclude con un breve rimando alla cultura del rinascimento anticipatrice di uno spirito in cui scienza, conoscenza e tecnica sono tra loro fortemente legate. La sperimentazione che ha luogo nel rinascimento, nella bottega dell'artigiano, diventa punto di partenza e filo unificante di diverse istanze della conoscenza e dell'arte, della ricerca scientifica e dell'esplorazione tecnica.
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Trilles Calvo, Karina P. "Fenomenología y realidad virtual: el reto de un nuevo mundo." Arbor CLXXXV, no. 736 (2009): 427–35. http://dx.doi.org/10.3989/arbor.2009.i736.291.
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Longo, Giuseppe. "Tecnologia, reti sociali e intelligenza collettiva." SOCIOLOGIA DELLA COMUNICAZIONE, no. 40 (June 2010): 12–34. http://dx.doi.org/10.3280/sc2009-040003.
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Oggi l'evoluzione biologica basata su mutazioni genetiche č di gran lunga superata dalla molto piů rapida evoluzione della cultura e della tecnologia. Ciň ha due conseguenze importanti: 1) la nascita dell'homo technologicus, una creatura simbiotica dove la biologia incontra la tecnologia; 2) la costituzione della Creatura Planetaria, che ha origine dall'interconnessione dei singoli simbionti uomo-macchina, ed č annunciata da Internet e dalle attivitŕ di comunicazione che vi operano, in particolare quelle che avvengono nei cosiddetti social networks. La Creatura Planetaria č una struttura singola che pervade tutto il mondo, dove hanno luogo processi comunicativi e cognitivi, che si sviluppano in un'intelligenza connettiva che tende a trascendere e ad assorbire le intelligenze individuali. Questo processo puň arricchire le capacitŕ degli individui, dato che la crescente efficienza e i costi decrescenti della comunicazione offrono grandi opportunitŕ per aumentare conoscenza e creativitŕ e ottenere nuove forme di attivitŕ intellettuale. Potrebbero esservi anche conseguenze negative, come dipendenza da computer e dal mondo virtuale, delega di attivitŕ e di capacitŕ alle macchine, vulnerabilitŕ di sistemi complessi, controllo indebito sui singoli, sfruttamento economico. Il lavoro esamina alcune importanti conseguenze di questi sviluppi.
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Maxwell, Patrick. "Virtual Religion in Context." Religion 32, no. 4 (2002): 343–54. http://dx.doi.org/10.1006/reli.2002.0410.
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MacWilliams, Mark W. "Virtual Pilgrimages on the Internet." Religion 32, no. 4 (2002): 315–35. http://dx.doi.org/10.1006/reli.2002.0408.
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Fontana, Renato. "Oltre la terziarizzazione dei conflitti: medialitŕ e virtualitŕ." RIVISTA TRIMESTRALE DI SCIENZA DELL'AMMINISTRAZIONE, no. 2 (July 2012): 15–29. http://dx.doi.org/10.3280/sa2012-002002.
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Il percorso lungo il quale si articola questo contributo muove dalle forme convenzionali tipiche di quello conosciuto come il conflitto di classe fino a quelle odierne, dove spesso prevalgono le dimensioni della medialitŕ e pure della virtualitŕ. Le forme prese in considerazione saranno le seguenti: il conflitto di classe; il conflitto terziario; il conflitto mediatico; il conflitto virtuale. Mentre il primo tipo presuppone un confronto diretto e immediato, il secondo chiama in campo il ruolo giocato dai media. Ma č soprattutto con il terzo tipo che i media, piů che i sindacati e le istituzioni, conferiscono ai conflitti quella legittimazione sociale di cui essi hanno bisogno per far emergere i problemi legati al mondo del lavoro e per dargli risonanza sul piano pubblico. Quanto piů un problema č conosciuto tanto piů sarŕ urgente risolverlo. Il conflitto virtuale, da ultimo, si gioca tutto sulla Rete ma sarebbe erroneo ritenere che le sue implicazioni non abbiano riflessi sulla vita quotidiana dei soggetti che abitano nelle strutture organizzative, come cercheremo di dimostrare.
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Calvo, Angel. "Reti di telecomunicazione: la diffusione urbana del telefono in Spagna, 1877-1930." STORIA URBANA, no. 119 (February 2009): 75–99. http://dx.doi.org/10.3280/su2008-119005.
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- Cities were the natural environment for the spread of telephone services in the early phase of the new technology of vocal communication. The expansion of the telephone in the Spanish cities took place with a relative delay with respect to other European countries. The reasons for this relative delay were as much economic (rent and tariffs) as institutional, mainly the unstable government policy and the regime of concessions. The period between 1877-1930 analyzed here is rich in contrasts since it includes the passage from an overwhelming predominance of local networks, private as well as public, to a regime of virtual monopoly towards the creation of a system unified under a private monopoly with very few exceptions.
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G.P. Flora, Matteo, and Edel Margherita Beckman. "Non-consensual pornography e victim blaming. Ruolo e responsabilità sociale." PSICOBIETTIVO, no. 2 (June 2021): 111–24. http://dx.doi.org/10.3280/psob2021-002007.
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Il confine che separa la vita reale da quella virtuale dipende principalmente da quanto una riesce ad influenzare l'altra. Difatti, quanto più le due dimensioni si influenzano tra loro, diventando una la longa manus dell'altra, tanto più sarà difficile tenerle separate. E come sempre accade ed è ora più evidente, ciò che accade on-line ha conseguenze anche off-line per gli individui. E tra i diversi reati che possono essere commessi on-line si annovera anche la nonconsensual pornography (o pornografia non-consensuale), una delle peggiori forme di sfruttamento sessuale e violazione della privacy (nonché dell'intimità) perpetrata in rete, con conseguenze che si estendono anche all'off-line andando a colpire la vittima a 360 gradi. Il termine non-consensual pornography viene utilizzato da parte della comunità scientifica per indicare l'illecita condivisione di immagini o video sessualmente espliciti, destinati a rimanere privati, senza il consenso della persona rappresentata, al fine di arrecare un danno alla vittima. In questo articolo vengono elencate le principali problematiche rilevate in oltre 18 mesi di lavoro costante sul campo del contrasto alla pornografia non-consensuale, affrontate nell'esperienza di PermessoNegato APS, una no-profit di promozione sociale che offre supporto tecnologico e legale alle vittime, elaborando non solo le statistiche delle tipologie di intervento, ma anche le principali conseguenze psicologiche del fenomeno sulle vittime.
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Mura, Marina, and Massimo Martini. "Identitŕ sociale e comunicazione in rete." DiPAV - QUADERNI, no. 25 (September 2009): 33–54. http://dx.doi.org/10.3280/dipa2009-025003.
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- In this article, we analyzed the concept of social identity complexity - a theoretical construct that refers to an individual's subjective representation of the interrelationships among his or her multiple group identities - in presence and virtual experiences. We thought social identity complexity reflects the degree of overlap perceived to exist between groups of which a person is simultaneously a member. Today, computer mediated communication (CMC) has a main point and meaningful influence in the construction of the social identity but the interaction with entity cognitive and the different levels of mediation has been a little considered.
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Oosterbaan, Martijn. "Virtual Migration. Brazilian Diasporic Media and the Reconfigurations of Place and Space." Revue européenne des migrations internationales 26, no. 1 (2010): 81–102. http://dx.doi.org/10.4000/remi.5037.
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Ho, Kim Hin David, and Shea Jean Tay. "REIT market efficiency through a binomial option pricing tree approach." Journal of Property Investment & Finance 34, no. 5 (2016): 496–520. http://dx.doi.org/10.1108/jpif-01-2016-0004.
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Purpose – The purpose of this paper is to examine the risk neutral and non-risk neutral pricing of Singapore Real Estate Investment Trusts (S-REITs) via comparing the average of the individual ratios (of deviation between expected and observed closing price/observed closing price) with the ratio (of standard deviation/mean) for closing prices via the binomial options pricing tree model. Design/methodology/approach – If the ratio (of standard deviation/mean) ratio > the ratio (of deviation between expected and observed closing price/observed closing price), then the deviation of closing prices from the expected risk neutral prices is not significant and that the S-REIT is consistent with risk neutral pricing. If the ratio (of deviation between expected and observed closing price/observed closing price) is greater, then the S-REIT is not consistent with risk neutral pricing. Findings – Capitacommercial Trust (CCT), Capitamall Trust (CMT) and Keppel Real Estate Investment Trust (REIT) have large positive differences between the two ratios (39.86, 30.79 and 18.96 percent, respectively), implying that these S-REITs are not trading at risk neutral pricing. Suntec REIT has a small positive difference of 2.35 percent between both ratios, implying that it is trading at risk neutral pricing. Ascendas REIT has the largest negative difference between the two ratios at −4.24 percent, to be followed by Mapletree Logistics Trust at −0.44 percent. Both S-REITs are trading at risk neutral pricing. The analysis shows that CCT, CMT and Keppel REIT exhibit risk averse pricing. Research limitations/implications – Results are consistent with prudential asset allocation for viable S-REIT portfolio investing but that not all these S-REITs exhibit strong market efficiency in their pricing. Practical implications – Pricing may be risk neutral over a certain period but investor sentiments, fear of risks and speculative activities could affect an S-REIT’s risk neutrality. Social implications – With enhanced risk diversification activities, the S-REITs should attain risk neutral pricing. Originality/value – Virtually no research of this nature has been undertaken for S-REITS.
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Orazi, Francesco. "Innovazione, tecnologia e governance: il ruolo dell'universitŕ nel rilancio delle economie locali." SOCIOLOGIA DEL LAVORO, no. 125 (March 2012): 155–73. http://dx.doi.org/10.3280/sl2012-125010.
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L'articolo, a partire da ipotesi innovative di governance (Rete di Competenza) descrive il ruolo strategico dell'universitŕ in un contesto di economie basate sul fattore conoscenza, mettendo in luce ipotesi di ammodernamento dei sistemi territoriali. L'obiettivo del lavoro intende verificare le condizioni di persistenza, presso i territori provinciali della Terza Italia, di condizioni favorevoli per lo sviluppo di tessuti produttivi innovativi basati sui fattori tecnologia e conoscenza e caratterizzati per capacitŕ operative di tipo reticolare/virtuale. Il prodotto della ricerca da un lato propone una specifica pratica di governance diffusa per il coordinamento istituzionale delle risorse di sviluppo, dall'altro una dorsale connettiva web based per l'interazione strategica degli attori produttivi, istituzionali e sociali e per l'incremento delle attivitŕ di networking territoriale e virtuale.
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DAMBRAUSKIENĖ, RAMUNĖ. "RETI IR VERTINGI LIETUVIŠKI KONTRAFAKCINIAI LEIDINIAI (1865–1904) KAUNO APSKRITIES VIEŠOJOJE BIBLIOTEKOJE." Knygotyra 56 (January 1, 2011): 202–16. http://dx.doi.org/10.15388/kn.v56i0.1503.
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Kauno apskrities viešoji bibliotekaRadastų g. 2, LT-44164 Kaunas, LietuvaEl. paštas: ramuned@kvb.ltSpaudos draudimo metais leisti lietuviškieji kontrafakciniai leidiniai užima svarbią vietą tarp Kauno apskrities viešojoje bibliotekoje saugomų spaudos paveldo objektų. Straipsnyje nagrinėjama šių leidinių repertuaro sudėtis, egzempliorių savybės, įrišimai, knygos ženklai, marginalijos. Dėl istoriškai susiklosčiusių kontrafakcijų gamybos bei sklaidos aplinkybių, caro valdžios vykdomo persekiojimo dauguma išlikusių leidinių yra reti. Turimi duomenys leidžia daryti išvadą, kad kontrafakcijų rinkinio knygos dėl retų egzempliorių, rankraštinių įrašų kirilika ir lotyniškais rašmenimis, marginalijų ir kitų knygos ženklų yra vertingas knygos ir kultūros istorijos tyrinėjimų šaltinis.Reikšminiai žodžiai: nacionalinė bibliografija, knygos istorija, spaudos draudimas, kontrafakcijos, spaudos paveldas, knygų įrišimai, knygos ženklai, proveniencijos, marginalijos.RARE AND VALUABLE LITHUANIAN CONTRAFACTIONS (1865–1904) OF THE KAUNAS COUNTY PUBLIC LIBRARYRAMUNĖ DAMBRAUSKIENĖ AbstractOld and Rare Books Department of the Kaunas County Public Library (further referred to as KCPL) preserves over 200 thousand copies of books, periodicals, maps, manuscripts from the 15th–mid 20th century in Lithuanian and foreign languages. Written cultural heritage stored in the library is the only heritage of this type in Kaunas County and the largest among all County Public Libraries of Lithuania. An important part of the collection is Lithuanian contrafactions published in the press prohibition period (1864–1904). The collection contains 465 publications of 218 titles, which constitute 26.2 percent of all published contrafactions (833). According to the presently known statistics, 41.7 percent of the contrafactions stored at the KCPL are rare (up to 10 remaining copies); among them, there are 2 unique publications, 12 rarities, 19 especially rare publications. The major part of the collection consists of religious publications: prayer-books, saints’ lives, ascetic literature, etc. One fifth of the collection consists of secular books: fiction, calendars, household-practical books, etc. The low quality of polygraphy and artistry of their bindings are mostly due to contrafaction production and distribution conditions. Books were published at a low price, paperback, small in size and volume. More impressive were only prayer-book bindings. In the collection, 185 books are marked with various ownership insignias. There were found 255 book insignias: 124 institutional and personal stamps, 111 manuscript inscriptions, 12 glue marks, 4 ex-librises, 4 super-ex-librises; 51 books contain marginalia, mostly those from the Samogitian Priest Seminary Library. Manuscript inscriptions written in the Cyrillic alphabet show the influence of the press prohibition period on the culture of Lithuanian script. Provenances of the KCPL contrafactions, marginalia, book binding, etc. reflect the reading culture of the late 19th–early 20th century and are a source for the further investigation of the book and script history. The KCPL contrafactions are a significant supplement of national bibliography: 321 copies are not registered in the publications of retrospective national bibliography and in the data-bank of the Bibliography and Book Science Centre of the National Library. This written heritage is valuable for the Kaunas region for its amount and content, which represents the period of press prohibition. The second stage of creating virtual libraries, which has started in regional libraries, will guarantee the preservation and spread of this heritage.rif'; text-transform: uppercase;">
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Manetti, Gabriele, Maria Giulia Lolli, Elena Belloni, and Giuseppe Nigri. "A new minimally invasive technique for the repair of diastasis recti: a pilot study." Surgical Endoscopy 35, no. 7 (2021): 4028–34. http://dx.doi.org/10.1007/s00464-021-08393-2.
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Abstract Background Diastasis recti is an abdominal wall defect that occurs frequently in women during pregnancy. Patients with diastasis can experience lower back pain, uro-gynecological symptoms, and discomfort at the level of the defect. Diastasis recti is diagnosed when the inter-rectus distance is > 2 cm. Several techniques, including both minimally invasive and open access surgical treatment, are available. Abdominoplasty with plication of the anterior rectus sheath is the most commonly used, with the major limitation of requiring a wide skin incision. The new technique we propose is a modification of Costa’s technique that combines Rives–Stoppa principles and minimally invasive access using a surgical stapler to plicate the posterior sheaths of the recti abdominis. Methods It is a fully laparoscopic technique. The pneumoperitoneum is induced from a sovrapubic trocar, placed using an open access technique. The posterior rectus sheath is dissected from the rectus muscle using a blunt dissector to create a virtual cavity. The posterior sheets of the recti muscles are plicated using an endo-stapler. A mesh is then placed in the retromuscular space on top of the posterior sheet without any fixation. Using a clinical questionnaire, we analyzed the outcomes in 74 patients who underwent minimally invasive repair for diastasis of the rectus abdominis sheath. Results Seventy-four patients (9 men and 65 women) were treated using this technique. Follow-up was started two months after surgery. All procedures were conducted successfully. There were no major complications or readmissions. No postoperative infections were reported. There were two recurrences after six months. There was a significant reduction in symptoms. Conclusions This new method is feasible and has achieved promising results, even though a longer follow-up is needed to objectively assess this technique.
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D'Ambrosi, Lucia, and Laura Massoli. "Attivismo giovanile e media sociali: tra consumi civici e sviluppo di capitale sociale." SOCIOLOGIA DELLA COMUNICAZIONE, no. 43 (September 2012): 105–19. http://dx.doi.org/10.3280/sc2012-043007.
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L'articolo esamina le istanze motivazionali dei giovani che aderiscono ai movimenti partecipativi in Rete, in relazione alla capacitŕ di produrre capitale sociale. L'analisi, condotta attraverso la survey online, pone in rilievo interessanti linee interpretative circa la capacitŕ dei giovani di connettere il vissuto online con quello reale e di creare legami sociali di tipo bridging. Nello specifico, le autrici evidenziano tre profili di giovani attivi: i "connessi ludici", gli "impegnati sul territorio", gli "acculturati virtuali" la cui vocazione emozionale connessa alla partecipazione presenta molteplici riferimenti valoriali. L'adesione ai movimenti si gioca su un ampio set di motivazioni lungo una linea di polarizzazione che vede contrapposto il bisogno di un riconoscimento sociale all'identificazione con una propria filosofia di vita.
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Caramori, Alessandra Paola, Jéssica Mahyara Teixeira, Suelen Najara de Mello, and Marlon Da Fonseca Misceno de Araújo. "O ensino de italiano no âmbito da Rede Andifes Idiomas sem Fronteiras nos tempos de ensino." Revista Italiano UERJ 12, no. 1 (2021): 20. http://dx.doi.org/10.12957/italianouerj.2021.62140.
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RESUMO: A Educação, no ano de 2020, a partir do início da pandemia de Covid-19, sofreu grande impacto com o fechamento das instituições escolares e consequente transformação das aulas presenciais em remotas. Nos cursos de língua italiana das Universidades Federais da Rede IsF-italiano, fomentadas pela Embaixada Italiana, a mudança do presencial para o remoto foi súbita, ainda no mês de março de 2020, obrigando-nos à transformação abrupta de modalidade de ensino/aprendizagem e de nossas práticas. Como as orientações pedagógicas para a formação continuada dos professores vinham sendo feitas, desde o início do Programa IsF-italiano, em 2016, na modalidade a distância, não estávamos totalmente afastados do mundo virtual, mas essa orientação se dava na direção das aulas em presença física. Com o passar dos meses, sempre na busca de novos conhecimentos, novos meios, recursos e ferramentas tecnológicos e de seus usos, e no compartilhamento constante destes saberes entre os professores, chegamos ao final de 2020, com muitos e relevantes aprendizados.Palavras-chave: Formação continuada de professores de italiano. Ensino/aprendizagem de língua italiana. Rede IsF-italiano. Ensino remoto. Covid-19. ABSTRACT: L'istruzione, nell'anno 2020, dall'inizio della pandemia Covid-19, ha subito un grande impatto, con la chiusura delle istituzioni scolastiche e la conseguente trasformazione delle classi in classi a distanza. Nei corsi di lingua italiana delle Università Federali della Rete IsF-italiano, sostenuti dall'Ambasciata Italiana, il cambiamento si è fatto all'improvviso, ancora nel mese di marzo 2020, costringendoci ad una brusca trasformazione della modalità di insegnamento/apprendimento e delle nostre pratiche didattiche. Poiché gli orientamenti pedagogici per la formazione continua degli insegnanti sono state fatte dall'inizio del Programma IsF-italiano, nel 2016, in modalità a distanza, non eravamo del tutto lontani dal mondo virtuale, ma questo orientamento è stato dato nella direzione delle classi in presenza fisica. Nel corso dei mesi, sempre alla ricerca di nuove conoscenze, nuovi mezzi, ricorsi e strumenti tecnologici e dei loro usi, e nel compartire costanti di questi saperi tra i professori, siamo arrivati alla fine del 2020, con molti apprendimenti rilevanti.Parole chiave: Formazione continua di professori di italiano. Insegnamento/apprendimento di lingua italiana. Rete IsF-italiano. Insegnamento (da) remoto. Covid-19. ABSTRACT: Education, from the beginning of the Covid-19 pandemic in the year 2020, suffered great impact with the closure of school institutions and the consequent transformation of traditional classroom classes into remote classes. In the Italian language courses of the Federal Universities of the Rete IsF-Italiano, promoted by the Italian Embassy, the change from formal to remote was sudden, still in March 2020, forcing us to abruptly change the teaching/learning modality and our practices. Since the pedagogical guidelines for the continued formation of teachers had been made, since the beginning of the Programa Italiano-Isf in 2016, in the distance mode, we were not utterly far from the virtual world, yet this orientation was proposed in the direction of the classes in physical presence. Over the months, always searching for new knowledge, new means, technological resources and tools, and their uses, and the constant sharing of this knowledge among teachers, we arrived, at the end of 2020, with many relevant learnings.Keywords: Further training of Italian teachers. Italian language teaching/learning. Isf-Italian Network. Remote teaching. Covid-19.
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Mülbert, Ana Luisa, and Osmar de Oliveira Braz Junior. "INTERAÇÕES ESPONTÂNEAS EM AMBIENTE VIRTUAL DE APRENDIZAGEM POR MEIO DE DISPOSITIVOS MÓVEIS: UM MAPEAMENTO BASEADO NA ANÁLISE DE REGISTROS DE ACESSO AO SISTEMA." Revista Eletrônica de Sistemas de Informação 15, no. 2 (2016): 3. http://dx.doi.org/10.21529/resi.2016.1502003.
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Ballarà, Francesco Castellet y. "Pornografia, masturbazione e trauma relazionale precoce." PSICOBIETTIVO, no. 2 (June 2021): 52–64. http://dx.doi.org/10.3280/psob2021-002003.
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L'Autore, dopo una ampia introduzione sulle basi neurobiologiche ed evolutive della sessualità e dell'autoerotismo, si occupa del fenomeno odierno della pornografia in rete e del sesso virtuale, evidenziando come essi siano ormai parte della nostra sessualità a tutte le età e come essi influenzino e siano influenzati dalle nostre fantasie erotiche. Nella relazione analitica con persone inibite e ritirate, può essere cruciale riuscire a fare in modo che gli stati dissociati della mente tipici dell'autoerotismo possano essere nominati e condivisi. Tale condivisione può essere un mezzo per esplorare il mondo degli oggetti interni del paziente in generale e in particolare nei disturbi correlati ai traumi relazionali precoci.
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Lima, Maiara Afonso Afonso de, Vinícius Peretti, and Fernanda Silva Veloso. "Reflexões sobre a prática docente e experiências de futuros professores em cursos de língua online do FIVU (Formação em Idiomas para a Vida Universitária)." Revista Italiano UERJ 12, no. 1 (2021): 21. http://dx.doi.org/10.12957/italianouerj.2021.62141.
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RESUMO: Com o auto isolamento exigido pelo COVID-19, o ensino presencial, parte fundamental da experiência de estágio, se tornou inviável implicando e favorecendo o aparecimento de novos campos para a sua realização. Surge, assim, a oferta de cursos de línguas, ainda que temporária, para o ensino remoto emergencial (ERE), como, por exemplo, as aulas do FIVU. Este artigo tem como objetivo principal apresentar e discutir a elaboração e a aplicação de unidades temáticas de língua italiana elaboradas por dois alunos do curso de Letras Italiano, regularmente matriculados na disciplina de Prática de Ensino de Línguas Estrangeiras Modernas Neolatinas 1, além de apresentar sua experiência didática nas regências em sala de aula virtual. A unidade didática e as aulas virtuais foram viabilizadas por meio de compartilhamento de tela, apresentações de slides, bem como por aplicativos online, como o Mentimeter e o Learning Apps. Os cursos de extensão de Língua Italiana estão vinculados ao projeto de extensão FIVU (Formação em Idiomas para a Vida Universitária) e foram viabilizados por meio de uma parceria entre docente orientadora, alunos estagiários e Programa de Pós-Graduação em Educação (PPGE) da Universidade Federal do Paraná (UFPR). O curso de nível básico, e com duração de 30 horas, foi ministrado no Teams Office 365 institucional e teve uma carga horária semanal de 4 horas-aula. O público-alvo foram nove alunos de mestrado e doutorado do PPGE-UFPR, muitos deles já com conhecimento prévio da língua italiana devido às leituras de suas bibliografias de pesquisa.Palavras-chave: Prática de ensino. Ensino remoto emergencial. Unidade didática. ABSTRACT: Con l'isolamento causato dal COVID-19, i lavori faccia a faccia sono diventati irrealizzabili, implicando e favorendo la comparsa di nuovi campi di stage adatti a questa nuova realtà. Nasce così la possibilità di offrire corsi di lingua, anche se temporanei, per la didattica a distanza di emergenza. I corsi di estensione della Lingua Italiana sono vincolati al progetto di estensione FIVU (Formação em Idiomas para a Vida Universitária) e sono stati resi possibili attraverso una partnership tra studenti, professoressa e Programa de Pós-Graduação em Educação (PPGE) dell’Universidade Federal do Paraná (UFPR). Il corso di livello principiante della durata di 30 ore è stato tenuto presso il Teams Office 365 istituzionale, ed ha avuto un carico di lavoro settimanale di 4 ore di lezione. Il pubblico di riferimento era di nove studenti di master e dottorato del PPGE-UFPR e molti di loro avevano già una conoscenza precedente della lingua italiana a causa delle letture delle loro bibliografie di ricerche. L’obiettivo principale di questo articolo è presentare e discutere lo sviluppo e l’applicazione delle unità didattiche elaborate da due studenti del corso di Lettere Italiano, iscritti alla disciplina di Prática de Ensino de Línguas Estrangeiras Modernas Neolatinas, oltre a presentare l’esperienza didattica degli studenti nell’insegnamento di italiano in una una classe virtuale. Le unità didattiche e le lezioni virtuali sono state fatte attraverso la condivisione dello schermo, presentazioni di diapositive, nonché attraverso applicazioni online, come Mentimeter e Learning Apps.Parole-chiave: Pratica di insegnamento. Didattica a distanza di emergenza. Unità didattica. ABSTRACT: With the self-isolation required by COVID-19, face-to-face teaching, a fundamental part of the internship experience, became unfeasible, implying and favoring the appearance of new fields for its realization. Thus, there came the offer of language courses, even though temporary, for emergency remote education (ERE), such as the FIVU classes. The main objective of this article is to present and discuss the development and application of thematic units of Italian language prepared by two students of the Italian Language course, regularly enrolled in the Teaching Practice of Neolatine Modern Foreign Languages, in addition to presenting their didactic experience in the regency in a virtual classroom. The didactic unit and virtual classes were made possible through screen sharing, slide shows, as well as through online tools, such as Mentimeter and Learning Apps. The Italian language extension courses are linked to the FIVU extension project (Training in Languages for University Life) and were made possible through a partnership between the faculty advisor, the intern students, and the Graduate Program in Education (PPGE) of the Federal University of Paraná (UFPR). The basic level course, with a duration of 30 hours, was given through the institutional Teams Office 365 and had a weekly load of 4 class hours. The target audience was nine master's and doctoral students from PPGE-UFPR, many of whom already had prior knowledge of the Italian language owing to the readings of their research bibliographies.Keywords: Teaching practice. Emergency remote education. Didactic unit.
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Fisher, Jane S., Katie J. Turner, Hamish M. Fraser, Philippa T. K. Saunders, Dennis Brown, and Richard M. Sharpe. "Immunoexpression of Aquaporin-1 in the Efferent Ducts of the Rat and Marmoset Monkey during Development, Its Modulation by Estrogens, and Its Possible Role in Fluid Resorption*." Endocrinology 139, no. 9 (1998): 3935–45. http://dx.doi.org/10.1210/endo.139.9.6213.
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Abstract Recent data suggest that estrogens play a role in regulating fluid resorption from the efferent ducts, though the biochemical mechanisms involved are unknown. The present study has used immunocytochemistry to localize a water channel protein, Aquaporin-1 (AQP-1), to the efferent ducts of male rats and marmoset monkeys from perinatal life through to adulthood and has then investigated its potential hormonal regulation in neonatal/peripubertal life, via administration of a GnRH antagonist (GnRHa) or diethylstilbestrol (DES) to rats. AQP-1 was immunoexpressed intensely in the apical brush border of the epithelium lining the efferent ducts at all ages studied, from late fetal life through puberty to adulthood. In the marmoset, but not the rat, AQP-1 was also expressed in the epithelium of the rete testis. Once the cell types within the efferent duct epithelium had differentiated, it was clear that only nonciliated cells of the rat localized AQP-1. When gonadotropin secretion was suppressed in rats by neonatal administration of GnRHa, immunoexpression of AQP-1 at age 18 and 25 days was virtually unchanged in intensity, though the efferent ducts were reduced in size. In contrast, when DES was administered neonatally to rats (up to day 12), immunoexpression of AQP-1 was reduced at day 10, virtually abolished at day 18, reduced markedly at day 25 and to a small extent at day 35; these findings were confirmed by Western blot analysis at day 18. The DES-induced decrease in immunoexpression of AQP-1 was accompanied by pronounced distension of the efferent ducts and rete, consistent with reduced fluid resorption. The epithelial cells of the efferent ducts in DES-treated rats were cuboidal rather than columnar in shape as in controls and were reduced significantly in height compared with controls at all ages through to adulthood. These findings suggest that estrogens may play a role in regulating fluid resorption from the efferent ducts during fetal/neonatal development and/or a role in the gross and functional development of the efferent ducts and rete testis. The present data also suggest that AQP-1 is one of the elements involved in the regulation of fluid resorption in the efferent ducts. The importance of fluid flow in fetal/neonatal development of the excurrent duct system of the male is also suggested by these observations.
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Huang, Boyin, Peter H. Stone, Andrei P. Sokolov, and Igor V. Kamenkovich. "The Deep-Ocean Heat Uptake in Transient Climate Change." Journal of Climate 16, no. 9 (2003): 1352–63. http://dx.doi.org/10.1175/1520-0442-16.9.1352.
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Abstract The deep-ocean heat uptake (DOHU) in transient climate changes is studied using an ocean general circulation model (OGCM) and its adjoint. The model configuration consists of idealized Pacific and Atlantic basins. The model is forced with the anomalies of surface heat and freshwater fluxes from a global warming scenario with a coupled model using the same ocean configuration. In the global warming scenario, CO2 concentration increases 1% yr−1. The heat uptake calculated from the coupled model and from the adjoint are virtually identical, showing that the heat uptake by the OGCM is a linear process. After 70 yr the ocean heat uptake is almost evenly distributed within the layers above 200 m, between 200 and 700 m, and below 700 m (about 20 × 1022 J in each). The effect of anomalous surface freshwater flux on the DOHU is negligible. Analysis of the Coupled Model Intercomparison Project (CMIP-2) data for the same global warming scenario shows that qualitatively similar results apply to coupled atmosphere–ocean GCMs. The penetration of surface heat flux to the deep ocean in the OGCM occurs mainly in the North Atlantic and the Southern Ocean, since both the sensitivity of DOHU to the surface heat flux and the magnitude of anomalous surface heat flux are large in these two regions. The DOHU relies on the reduction of convection and Gent–McWilliams–Redi mixing in the North Atlantic, and the reduction of Gent–McWilliams–Redi mixing in the Southern Ocean.
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Camargo-Henández, Katherine del Consuelo, and Jacqueline Hernández-Sánchez. "Burnout syndrome in gerontological nursing: review of the theoretical and practical perspectives." Revista Ciencia y Cuidado 17, no. 2 (2020): 77–87. http://dx.doi.org/10.22463/17949831.1578.
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Introducción: Analizar las perspectivas teóricas y prácticas que muestran las publicaciones científicas a nivel mundial, con respecto al síndrome de burnout, en el personal de enfermería que ofrece cuidado a la población adulta mayor. Metodología: Se realizó una revisión de literatura en el contexto mundial de artículos publicados en inglés y español, en las bases de datos de ScienceDirect, Biblioteca Virtual en Salud-BVS, Dialnet y Redalyc, en el período de 2013 a 2018. Resultados: 15 publicaciones que cumplían con los criterios de inclusión. La mayoría de los artículos originales tenían como objetivo identificar la correlación entre el síndrome de quemarse por el trabajo o estresores laborales; solamente un artículo reporta la evaluación de una intervención. En ninguno de los artículos se hace referencia a la enfermería geriátrica, como parte del constructo en el que se basa el estudio; pero la mayoría sí definen el burnout. Conclusiones: La evidencia científica revisada sobre el burnout en enfermería geriátrica es escasa, lo cual reta a investigar más, así como a publicar. También es necesario hacer explícitos estos dos constructos. Los resultados sugieren mejoras para futuros estudios en relación con los objetivos, la metodología y las intervenciones.
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Senkāne, Olga, and Karīne Laganovska. "ACQUISITION OF JEWISH CULTURAL HERITAGE OF LATGALE IN REGIONAL EDUCATIONAL ESTABLISHMENTS: DISCOURSE OF CULTURAL MEMORY." SOCIETY, INTEGRATION, EDUCATION. Proceedings of the International Scientific Conference 1 (May 9, 2015): 515. http://dx.doi.org/10.17770/sie2012vol1.78.
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In the context of culture and history discourse and sociological analysis the interdisciplinary research reveals the significance of Jewish cultural heritage in the multinational Latgale region. Therefore, there are described topical tools in the research and preservation of Jewish cultural values and evaluated the necessity for acquisition of this culture at regional educational establishments. Prior to holocaust the ethnical group of Jews was one of the largest minorities in Latgale and had significant impact on the socio-economic and cultural development of the region. As a result of the research, it was found out that pupils and students possess knowledge about holocaust, but they have no clue about the life of this minority in Latgale before World War II and nowadays. In order to solve the problem the authors of the article offer to integrate the respective cultural and historical material into the interdisciplinary link because the tool forming memory culture are the contemporary realia – museum exhibits, photos, exhibitions, cultural and historical monuments, former Jewish squares and streets, architectonics of preserved houses, etc. RHEI REGI has created a virtual museum “Jews in Latgale” as an interactive tool offering teachers, museum staff and other interested persons video films, witnessing interviews and other materials.
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Schuler, G., Y. Dezhkam, L. Tenbusch, MC Klymiuk, B. Zimmer, and B. Hoffmann. "SULFATION PATHWAYS: Formation and hydrolysis of sulfonated estrogens in the porcine testis and epididymis." Journal of Molecular Endocrinology 61, no. 2 (2018): M13—M25. http://dx.doi.org/10.1530/jme-17-0245.
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Boars exhibit high concentrations of sulfonated estrogens (SE) mainly originating from the testicular-epididymal compartment. Intriguingly, in porcine Leydig cells, sulfonation of estrogens is colocalized with aromatase and steroid sulfatase (STS), indicating that de novo synthesis of unconjugated estrogens (UE), their sulfonation and hydrolysis of SE occur within the same cell type. So far in boars no plausible concept concerning the role of SE has been put forward. To obtain new information on SE formation and hydrolysis, the porcine testicular-epididymal compartment was screened for the expression of the estrogen-specific sulfotransferase SULT1E1 and STS applying real-time RT-qPCR, Western blot and immunohistochemistry. The epididymal head was identified as the major site of SULT1E1 expression, whereas in the testis, it was virtually undetectable. However, SE tissue concentrations are clearly consistent with the testis as the predominant site of estrogen sulfonation. Results from measurements of estrogen sulfotransferase activity indicate that in the epididymis, SULT1E1 is the relevant enzyme, whereas in the testis, estrogens are sulfonated by a different sulfotransferase with a considerably lower affinity. STS expression and activity was high in the testis (Leydig cells, rete testis epithelium) but also present throughout the epididymis. In the epididymis, SULT1E1 and STS were colocalized in the ductal epithelium, and there was evidence for their apocrine secretion into the ductal lumen. The results suggest that in porcine Leydig cells, SE may be produced as a reservoir to support the levels of bioactive UE via the sulfatase pathway during periods of low activity of the pulsatile testicular steroidogenesis.
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Lee, Patrick Chi-Wai. "A DISCOURSE DESCRIPTION OF FOUR FUNDRAISING TEXTS – LINGUISTS MEET PRACTITIONERS: AN EXPLORATORY STUDY." Discourse and Interaction 9, no. 2 (2016): 25. http://dx.doi.org/10.5817/di2016-2-25.
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This exploratory study presents four fund-raising texts for an analysis. Two are written as appeal letters and two as leafl ets. Their purpose of writing is to persuade an audience of Hong Kong residents to donate money for charity organizations. A qualitative approach informed by ethnography is adopted. Interviews with two organizations are conducted and verbal reporting of practitioners is used. In this study, one focus is on the schematic structure of texts and fund-raising texts are recognized as a particular of genre. The ‘Problem-solution discourse pattern’ can be applied to the fund-raising texts even though practitioners did not acknowledge they use any linguistic models. As for the textual moves, ‘situation or problem’ is always placed at the beginning of the text because it is crucial to let readers know what the main theme is. Then there are diff erent combinations of the second move including ‘response, solution or problem’. The fi nal move is always ‘response’ and two meanings of ‘response’ are refi ned to diff erent parameters: (i) tangibility: tangible and virtual solution, (ii) time frame: proposed and reference solution, and (iii) depth of target-achievement: ultimate and specifi c solution. Another focus of this study is on the choice of style. As persuasion of readers to donate is crucial, adding involving devices is to engage readers and make them ‘particular’, which increases the possibility to solicit response successfully. Involvement devices include using you and imperative clauses. Finally, with reference to the issue of whether ‘textual structure tells us the reality’ or ‘the reality creates the structure’, practitioners are not concerned too much with text structure. Practically, the reality to them is embodied in the structure.
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Gini, Guido, Caterina Bocci, Michela Sampaolo, et al. "A Combination of Lenalidomide and Rituximab (ReRi) As Salvage Therapy in Elderly Patients Affected By Diffuse Large B Cells (DLBCL) Lymphoma Relapsed and Refractory." Blood 126, no. 23 (2015): 5109. http://dx.doi.org/10.1182/blood.v126.23.5109.5109.
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Abstract BACKGROUND The incidence of non Hodgkin's lymphoma (NHL) increases with age, over one third of NHL cases involves elderly patients >70 years of age. As a matter of fact, many elderly patients (pts) are not enrolled in controlled studies because they do not meet the inclusion criteria. This is the reason why the data from trials on elderly cases are not representative for the whole elderly population. Consequently, many of these patients do not benefit of new therapeutic progresses and the treatment is not yet adequate. Moreover in case of relapse, salvage therapy in the elderly is virtually absent, and the prognosis is extremely poor. Lenalidomide is an immunomodulatory drug with anti-angiogenetic and anti-neoplastic action on cancer cells and also has other anti-tumor activity by acting on the neoplastic microenvironment. Both monotherapy and combination of Lenalidomide with rituximab have shown efficacy in terms of overall response rate (ORR, Overall Response Rate) in the setting of salvage therapy in relapsed/refractory DLBCL, with an acceptable rate of hematologic and extra-hematological toxicities PATIENTS AND METHODS In the period 2013-2014 we consecutively treated 12 elderly patients affected by advanced DLBCL relapsed/refractory. Median age at the start of treatment was 79 years (yrs) (62-86), 5 out 12 was over 80 yrs and 4 out 12 over 75 yrs. The median number of previous treatment was 3 (2-4), 3 pts were transplanted and 4 patients was refractory to previous line of therapy. The treatment scheme included at first cycle: Rituximab 375 mg/m2 i.v. days 1, 8, 15, 22, Desametasone 5 mg p.o. days 1, 8, 15, 22 and Lenalidomide 15 mg/die p.o. from day 2 to 22. From the second to the sixth cycle we administered Rituximab 375 mg/m2 i.v. days 1, 14, Lenalidomide 20 mg/die p.o. from day 2 to 22 RESULTS The overall response rate has been 75% (CR,PR,SD), 3 patients out 12 (25%) achieved a CR and 3 PR (25%). The median PFS was 6 months and with a median follow up of 1 year the overall survival is 25%.(fig.1) All deaths are due to lymphoma progression and the 3 patients in CR are still alive in CCR. CONCLUSIONS In this elderly and heavily pretreated group of patients our scheme containing Lenalidomide-Rituximab has shown an high rate of response with a good rate of CR and a promising trend in overall survival. The treatment appears feasible and safe also in this particular group of frail patients and even if we need more data to confirm we think it will be possible to extend this therapy in frail elderly patients in a most precocious line of treatment. Figure 1. Figure 1. Disclosures Offidani: Celgene, Janssen: Honoraria.
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Smith, Frances, David Brawand, Laura Steedman, et al. "A Comprehensive Next Generation Sequencing Gene Panel Focused on Unexplained Anemia." Blood 126, no. 23 (2015): 946. http://dx.doi.org/10.1182/blood.v126.23.946.946.
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Abstract Congenital anemia is difficult to diagnose once common causes have been excluded; for example 80% cases of congenital non-spherocytic hemolytic anemia are undiagnosed once pyruvate kinase and G6PD deficiencies have been excluded using phenotypic analysis. We describe a next generation sequencing strategy, targeting 147 genes, to facilitate the diagnosis of these conditions. The coding regions, splice sites and 200 bp into the untranslated regions were examined in each gene. All clinically significant variants were confirmed by Sanger sequencing, including confirmation in any appropriate family members. Illumina MiSeq data was analysed using a bespoke bioinformatics pipeline, which has been validated to a UK certified standard. The pipeline implements detection of genetic variants using multiple base callers and discovery of copy number variants based on sequencing depth. Variants are annotated with information from ClinVar, and population frequency data from ExAC and 1000 genomes project. All genes are sequenced in every individual but data analysis can easily be restricted to virtual subpanels, excluding analysis of genes not requested. Here we present three cases, highlighting the diagnostic utility of the panel as well as the underlying bioinformatics analysis. Case 1. A male Caucasian child of <1 year, presented with haemolysis (LDH 539 IU/L, total bilirubin 39 umol/L), haematology (Hb 92g/L, MCV 84.4, MCH 28.9, absolute retic count 313.8x109/L); his film showed marked anisopoikilocytes, microspherocytes and polychromasia. He had frontal bossing and a palpable spleen and had suffered several infections, the child was transfused once. His father's film showed elliptocytes, FBC (Hb 127g/L, MCV 89.6, MCH 30.6, absolute retic count 230.5x109/L) but he had never been transfused. The mother's FBC was normal (Hb 113g/L, MCV 87.0, MCH 29.2, absolute retic count 48.4x109/L) but her film also showed elliptocytes. Analysis using the red cell panel found the child to be compound heterozygous for c.83G>A; p.Arg28His and c.[5572C>G; 6531-12C>T]; p.[Leu1858Val;?] in the SPTA1 gene, suggesting the diagnosis of hereditary pyropoikilocytosis. The c.83G>A; p.Arg28His mutation was inherited from the father and the c.[5572C>G; 6531-12C>T]; p.[Leu1858Val;?] low expression allele was inherited from the mother, who was homozygous. Case 2. The post mortem report from a hydropic still birth (36/40) showed extensive extramedullary hematopoiesis and severe anemia. A DNA sample was sent to the laboratory accompanied by blood samples from both parents whose hematology was normal. The DNA sample from the proband was relatively small so only the parental samples were analyzed using the red cell panel. Sequence analysis identified the mother to carry the c.3173dupG; p.Gln1659fs pathogenic variant and the father carried the c.2867_2868+1dupCCG pathogenic variant in the CDAN1 gene. Sanger Sequencing showed that the child had inherited both mutations from the parents. Variants in CDAN1 are associated with CDA type 1 which is documented to be a rare form of anemia which can be lethal. Case 3. An Italian girl carrying a paternally inherited c.118C>T β0 thalassemia variant presented with a severe form of microcytic anemia (FBC, Hb 86g/L, RBC 4.87 x1012/L, MCV 55.2, MCH 17.7 and HbA2=5%). The severity of her anemia (not transfused) and palpable spleen suggested she had an additional pathogenic variant that had not been identified. Her mother had normal hematology FBC, Hb 133g/L, RBC 4.82x1012/L, MCV 79.9, MCH 27.6. After sequencing, Exome Depth analysis of the proband's LCR identified a novel deletion which removed the 5' HS1 and HS2 sites but left HS3-5 intact (confirmed by MLPA in the mother and proband). The combination of this mild down regulation of the beta globin locus in combination with the c.118C>T β0 thalassemia variant caused her phenotype to be more severe than just a beta thalassemia carrier. Identifying pathogenic variants in these families is important as it facilitates prognosis and treatment, and allows prenatal diagnosis to be offered in future. To date the panel has assessed 10 cases of anemia with unknown cause and has made a definitive diagnosis in 8 (80%). Of the two undiagnosed, one was a child that died at 3 weeks and received multiple intrauterine and neonatal transfusions and had severe anemia and the other was a suspected case of CDA with little associated phenotype. Disclosures No relevant conflicts of interest to declare.
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Sanfilippo, Roberta, Marco Tricomi, Federica Grosso, et al. "The Italian Rare Cancer Network." Journal of Clinical Oncology 30, no. 15_suppl (2012): 10053. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.10053.
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10053 Background: Rare cancers (RC) are a challenge in terms of quality of care, access to health resources and clinical research. The Italian Rare Cancer Network (RTR: “Rete Tumori Rari”) is a clinical collaborative effort to improve quality of care in adult rare solid cancers in Italy. RTR enables institutions to share clinical cases and to rationalize access to distant reference centers minimizing patient migration. It indirectly promotes collaborative clinical research by encouraging accrual into clinical trials and supporting observational studies. Methods: RTR includes 150 oncology institutions across Italy. Clinical cases are shared asynchronously over a secure Web resource. Data, images and transactions are stored in an online clinical record. Patients are shared: 1. "logically”, when they are dealt with following common clinical practice guidelines; 2. "virtually”, when they are discussed over the network between two or more centers; 3: "physically", when they are referred to an excellence center for a specific treatment modality. Pathology review is arranged through transferal of paraffin-embedded specimens and upload of consultations. While it was chosen not to implement telepathology facilities, a teleradiology resource is now available. Results: From 2003 to 2011, more than 5,000 rare cancers cases (mostly sarcomas) have been uploaded. More than 1,300 teleconsultations have been delivered, while more than 1,000 patients moved across the network during their experience of disease. 700 cases were reviewed pathologically: amongst 365 cases originally diagnosed as soft tissues sarcomas up to 2010, treatment-relevant discordances were recorded in more than one third. An observational prospective study on gastrointestinal stromal tumors was done, enrolling 800 patients. An original paper documenting the activity of a drug in a highly specific sarcoma subgroup was published. Conclusions: Clinical asynchronous online collaboration on RC is feasible through a Web-based secure environment and proved the most practical way of clinical distant sharing. Pathologic review was a crucial network service, with a special added value in RC. Retrospective and prospective observational studies, and unplanned observations in very rare cases, were an interesting by-product.
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Zaleskas, Virginia M., Wayne W. Chan, Peter Evangelista, et al. "A Selective and Potent Oral Inhibitor of the JAK2 Tyrosine Kinase Reverses Polycythemia and Leukocytosis Induced by JAK2 V617F in a Mouse Model." Blood 110, no. 11 (2007): 557. http://dx.doi.org/10.1182/blood.v110.11.557.557.
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Abstract A somatic mutation (V617F) in the pseudokinase domain of the non-receptor tyrosine kinase JAK2 is found in virtually all patients with the myeloproliferative disease (MPD) polycythemia vera (PV), and about half of those with essential thrombocythemia and chronic idiopathic myelofibrosis. When expressed in mice by retroviral bone marrow transduction and transplantation, JAK2 V617F but not JAK2 wild-type induces leukocytosis with neutrophilia and recapitulates the entire erythroid phenotype of PV, with polycythemia, reticulocytosis, low plasma Epo, and endogenous erythroid colonies (Zaleskas et al., PLoS ONE2006;1:e18; Wernig et al., Blood2006;107:4274; Lacout et al., Blood2006;108:1652). By analogy to BCR-ABL in chronic myeloid leukemia, JAK2 V617F is therefore a rational target for therapy in PV and other JAK2 V617F+ MPDs. Previous studies with a nonselective and parenteral tyrphostin JAK2 inhibitor suggested that short-term inhibition of JAK2 could decrease reticulocytosis in recipients of JAK2 V617F-transduced marrow (Zaleskas et al., op cit.). Here, we studied one of a novel series of inhibitors of JAK2, AZ-01, which potently inhibited JAK2 kinase activity (IC50 < 1nM) and suppressed proliferation of cell lines carrying the JAK2 V617F mutation. We treated cohorts of Balb/c mice with JAK2 V617F-induced polycythemia and leukocytosis with AZ-01 at 10 mg/kg by oral gavage twice daily, or with vehicle alone. After 28 days of treatment, AZ-01-treated mice had significant reductions in hematocrit, hemoglobin, reticulocytes, and splenomegaly, as well as normalization of peripheral blood leukocyte counts (Figure 1). These results demonstrate that oral administration of a potent and selective JAK2 inhibitor can reverse the hematopoietic abnormalities of JAK2 V617F-induced MPD in mice, and validate JAK2 as a target for therapy of human JAK2 V617F+ MPD. Figure Figure An orally available JAK2 inhibitor decreases the leukocyte count, hematocrit, and reticulocyte count in mice with JAK2 V617F-induced MPD. Leukocyte count (left), hematocrit (center) and reticulocyte counts (right) of cohorts of mice with JAK2 V617F-induced MPD treated with vehicle or drug at 10 mg/kg BID. Blood counts were assessed at 15 and 28 days of treatment. Decreases in d28 hematocrit and retic count in the drug-treated cohorts were significant (p=0.008 and p<0.0001, respectively, t-tests).
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Mancini, Elena. "L’autosperimentazione nelle malattie rare: analisi dei profili etici e indicazioni per una possibile governance / The self-experimentation on rare diseases: analysis of ethical profiles and instructions for a possible governance." Medicina e Morale 66, no. 1 (2017): 45–61. http://dx.doi.org/10.4081/mem.2017.475.
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Le malattie rare raggruppano un numero elevato di patologie molto diverse tra loro, accumunate, dalla bassissima frequenza statistica nella popolazione (penetranza). Ne consegue una scarsissima numerosità di pazienti per ogni singola patologia e una loro distribuzione in diverse aree geografiche, fattori che comportano oggettive difficoltà nel reclutamento dei pazienti in studi sperimentali e nel coordinamento e organizzazione della ricerca con conseguente ridotta possibilità di effettuare studi clinici e ricerche di carattere genetico. In tale quadro, al fine di fare fronte alle drammatiche necessità di assistenza socio-sanitaria, cura e riabilitazione dei malati rari, sono sorte, in gran parte per merito degli stessi familiari, le associazioni di malati rari. Attualmente tali associazioni svolgono un’attività significativa nella proposizione, organizzazione, partecipazione diretta e pubblicazione dei risultati di ricerche scientifiche. Tale ruolo, rende le associazioni dei pazienti protagoniste anche nel sostegno all’organizzazione e realizzazione di studi clinici e sperimentazioni di farmaci in modo del tutto autonomo e indipendente da controlli da parte delle autorità sanitarie e dei comitati etici. Tale fenomeno noto come “Research Led by Participants” è stato reso possibile dalle enormi potenzialità di contatto e organizzazione offerte dalla rete che ha consentito la creazione di comunità virtuali di pazienti, di siti e blog dedicati all’informazione e comunicazione, e più recentemente, alla raccolta di dati, alla pubblicazione di risultati di ricerche condotte dai malati, nonché al reclutamento degli stessi per la conduzione di tali studi, secondo il modello proposto, ad esempio, dal sito PatientsLikeMe. Non possono tuttavia essere trascurati gli importanti aspetti etici implicati dalla ricerca condotta dai partecipanti. Tali aspetti concernono, come evidente, sia la validità scientifica di tali studi che la protezione dei soggeti che aderiscono alla sperimentazione. Si tratta di una forma di sperimentazione del tutto nuova che richiede la capacità di proporre una modalità di gestione condivisa tra cittadini/pazienti, “terzo settore”, ricercatori, istituzioni e comitati etici in grado di valorizzarne i potenziali benefici conoscitivi creando regole etiche “misurate” su tali circostanze. Nell’articolo sarà proposto un modello teorico di governance del fenomeno e saranno indicati possibili criteri etici operativi. ---------- Rare diseases gather up a large number of different pathologies, all very different among them but similar for the low statistical attendance of population (penetrance). Therefore there is a very low number of patients sick of the same pathology and their presence in different geographical areas makes objectively difficult to recruit patients in order to study their disease and coordinate and organize the research of the pathology. As a consequence there is a very reduced possibility to carry on clinical studies and genetic researches. In this framework, in order to face the dramatic necessity of sociological and sanitary assistance, treatment and rehabilitation of the rare patients, families members generally organize Rare Diseases Patient Organizations. At the moment these organizations develop an important activity with regard to organization, proposals, direct participation and publication of the scientific research results. These organizations also play an important part in supporting the organization and the realization of clinical trials. They play in total autonomy and are independent from every ethical and scientific oversight by the sanitary authorities and ethical committees. This extraordinary event known as “Research Led by Participants”, has been realized thanks to the large contacts possibilities and organization offered by the web which made possible the creation of virtual communities of patients, of blog and web site for information and communication and, more recently, for collecting statistical data, publication of the patients research results and the recruitment of patients in order to manage the studies following the rules and models proposed, for example, by the web site “PatientsLikeMe”. We must however put in evidence the important ethical issues involved in the research led by the participants. These aspects concern, obviously, either the scientific validity of these studies or the protection of the subjects who accept to be submitted to the experimentation. It is a completely new way of experimentation that requires the capacity to propose and follow a governance that must be accepted and shared by citizens/patients, “third sector”, research workers, institutions and ethical committees able to exploit the potential advantageous knowledge and create ethical rules inspired to those new situations. In this article it will be proposed a theoretical model of governance of this phenomenon and also it will be outlined ethical rules for operative plans.
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Murphy, George F., Raimon Duran-Struuck, Evan A. Farkash, et al. "Histological Assessment of Cutaneous Acute Graft-Versus-Host Disease in a Preclinical Swine Model of Hematopoietic Cell Transplantation and Vascularized Skin Flap Tolerance." Blood 120, no. 21 (2012): 1894. http://dx.doi.org/10.1182/blood.v120.21.1894.1894.
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Abstract Abstract 1894 Graft-versus-host disease (GVHD) remains a frequent complication of hematopoietic cell transplantation with skin being a principal target organ. Murine models have provided some insight into the mechanisms of this complex disease process. However, mouse skin differs from human skin, and results of studies in rodents may not translate well to the clinic. Miniature swine is a well-recognized animal model for preclinical studies of skin including dermal toxicology, transdermal drug delivery and wound healing. Unlike skin of rodents, dogs or non-human primates, porcine skin is similar to human skin in terms of structure of epidermal rete ridges (Figure 1A), hair follicle structure and density, and presence of sweat glands and subcutaneous fat. We have developed a miniature swine model of haploidentical hematopoietic cell transplantation that results in stable stem cell engraftment, hematopoietic chimerism and donor skin flap tolerance without GVHD. Swine leukocyte antigen (SLA)ad animals receive 100cGy total body irradiation and T cell depletion using porcine CD3 immunotoxin prior to cytokine mobilized peripheral blood hematopoietic cell transplantation from a haploidentical SLAac donor. Daily cyclosporine is administered at doses adjusted to maintain serum levels between 400–800 ng/ml starting one day prior to transplantation and continued for 30 days with taper until day 45. Mixed hematopoietic cell chimerism persists in these animals and donor vascularized skin flaps are accepted without the need for maintenance immunosuppression regardless of whether they are placed at the time of hematopoietic cell transplantation or greater than 100 days later. Despite the initial resistance to GVHD in this model, acute cutaneous GVHD could be induced through infusion of a high dose of donor leukocytes (DLI) including 15 million donor T cells/kg recipient body weight administered 463 days post hematopoietic cell transplantation and 314 days post vascularized donor skin flap transplantation. Conversion to full donor hematopoiesis was observed between 3–4 weeks post DLI. At this time a mild skin rash was evident in both donor and host skin which appeared to progress specifically within host skin. The presence of both donor and host skin on a tolerant animal whose peripheral blood consists of a mixture of both donor and host derived hematopoietic cells provides a novel model to evaluate specific targets of acute GVHD. In this study we assess histologically the manifestations of acute GVHD in both donor and host skin and compare it to typical histological manifestations of acute GVHD observed in patients. Specifically, recipient skin developed superficial lymphoid infiltrates that progressed to confluence along the dermal-epidermal junction by day 21. These infiltrates were associated with intraepidermal migration, prominent basal cell layer keratinocyte apoptosis, and satellitosis virtually indistinguishable from grade 3–4 human cutaneous acute GVHD (Figure 1B). Superficial portions of hair follicles were involved, as also seen in human disease. Of interest, mild disease was detected in the donor skin grafts by day 62 post-DLI, where selective lymphoid infiltration in the tips of the epidermal rete ridges and in association with target cell apoptosis/satellitosis was documented, a finding remarkably similar to early targeting events in humans. These findings emphasize the value of the porcine model for translational studies of cutaneous GVHD. Preliminary data suggest differences in cellular targeting between recipient and donor skin whereby the latter may be triggered by the presence of chimeric recipient-derived hematopoietic elements that have populated donor grafts. Further studies are now possible to explore the effector-target cell interactions in this clinically-relevant model of human cutaneous GVHD. Figure 1: Comparison of normal porcine skin (A) resembling epidermal and dermal layers of human integument, and (B) recipient skin 34 days post DLI, showing brisk superficial lymphoid infiltrate associated with basal layer epidermal apoptosis. Figure 1:. Comparison of normal porcine skin (A) resembling epidermal and dermal layers of human integument, and (B) recipient skin 34 days post DLI, showing brisk superficial lymphoid infiltrate associated with basal layer epidermal apoptosis. Disclosures: No relevant conflicts of interest to declare.
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Carpenter, Chris. "Fiberglass-Lined Tubing Helps Prevent Asphaltene Deposition in Oil Wells." Journal of Petroleum Technology 73, no. 07 (2021): 55–56. http://dx.doi.org/10.2118/0721-0055-jpt.
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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper IPTC 21441, “First-Time Worldwide Application of Glass-Reinforced Epoxy-Lined Tubing for Prevention of Asphaltene Deposition in Tubing in Oil Wells: A Case Study From Kuwait,” by Reji E. Chinnappan, SPE, Milan Telang, SPE, and Riyad Quttainah, SPE, Kuwait Oil Company, et al., prepared for presentation at the virtual 2021 International Petroleum Technology Conference, 23 March–1 April. The paper has not been peer reviewed. Copyright 2021 International Petroleum Technology Conference. Reproduced by permission. Asphaltene deposition in production tubing represents a major flow-assurance challenge. Common strategies to mitigate asphaltene deposition downhole include mechanical or solvent cleanouts and chemical inhibition. These are associated with production deferment, high job costs, safety and environmental risks, and operational issues. An operator has addressed this challenge using production tubing lined with glass-fiber-reinforced epoxy (GRE). This technology was implemented in two trial wells. The paper describes the different mitigation strategies employed by the operator and presents the findings of successful trials. Background Jurassic wells of a Kuwait Oil Company asset are producing light crude from a tight matrix-type reservoir located at a depth of 13,000–15,000 ft. Reservoir pressure has depleted from approximately 9,500–10,000 psi to approximately 6,000 psi because of sustained production in the absence of any significant pressure support. Oil production rates per well have diminished to the 500- to 1,000-BOPD range. The oil features high asphaltene onset pressures (4,000–5,000 psi). When considering time-lapse plots of caliper logs from a well where asphaltene deposition used to occur, the plot indicates that significant asphaltene deposition in the well took place below 4,500 ft and progressively increased over time. In approximately 5 months, the average internal diameter of the tubing reduced from 2.75 in. to less than 2 in., thereby constricting the flow significantly and requiring cleaning of the tubing. In extreme cases, the tubing string could be fully plugged. Many field trials with different tools and chemicals using batch and continuous treatment have been conducted in past years to solve this problem but without satisfactory results. Application of GRE-Lined Tubing for Asphaltene Control The operator decided to apply a novel strategy of using tubing internally lined with GRE based on its established ability to retard, and even eliminate, scale nucleation and deposition. The technology uses a thin-walled, solid-filament-wound GRE/fiberglass tube run inside carbon steel production tubing. Cement is pumped into the annulus between the steel tubing and the GRE liner. The ability to prevent asphaltene from sticking to the inner wall of the tubing is attributed to the smoother internal surface. It is also corroborated by a higher Hazen Williams coefficient value of 150 for GRE as compared with 110 for carbon steel pipe, which provides for lesser frictional pressure loss during flow. The GRE liners used by the operator have a surface roughness of 0.00011 in., which, unlike bare steel, is retained over the life of the GRE. The GRE-lined tubing proved to withstand temperatures of up to 280°F and hydrogen sulfide concentrations of up to 50%. This is comfortably more than the process conditions for the trial wells in consideration.
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Vetrenko, Inna A. "THE BEGINNING OF A LARGE-SCALE POLITICAL REFORM IN RUSSIA: A NEW TURN IN 2020." Law Enforcement Review 4, no. 1 (2020): 14–20. http://dx.doi.org/10.24147/2542-1514.2020.4(1).14-20.
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The subject. The article is devoted to the analysis of the draft political and constitutional reform that was announced in the last Presidential Address to the Federal Assembly at January 15, 2020.
 The purpose of the article is to try to predict the positive and negative consequences of changing the legal status of the highest Russian authorities. 
 The methodology of the study includes analysis and interpretation of Presidential Ad-dresses to the Federal Assembly and Russian Constitution as well as dialectical approach and methods of political science. 
 The main results and scope of their application. For a long time there was a clear request for changes in the government, and various expert platforms discussed issues related to changing the Constitution of the Russian Federation, which was adopted at a national referendum in December 1993. 
 On January 15, 2020, Vladimir Putin addressed his 16th message to the Parliament. In ac-cordance with the Constitution, the President of Russia annually addresses the Federal Assembly with a message on the situation in the country and on the main directions of domestic and foreign policy. The last address turned out to be a landmark and historical one, as it announced the main provisions of the upcoming large-scale political and consti-tutional reform in Russia. Heads of constituent entities, members of the State Duma and the Federation Council, Prime Minister and Deputy Prime Ministers, Federal Ministers, heads of Fed-
 
 
 eral bodies, judges will no longer be able to have foreign citizenship or a foreign resi-dence permit. He proposed even more stringent requirements for a candidate for the post of President: no foreign citizenship or residence permit even in the past, as well as per-manent residence in Russia for at least 25 years. The position of the State Council is being strengthened and it is reflected in the Constitution of the Russian Federation as an insti-tution of power in the country. The position of the Federal Assembly is strengthened by the fact that the Parliament is given the right to approve the candidacy of the Prime Min-ister, as well as all Deputy Prime Ministers and Federal Ministers. The status of local self-government and the role of governors in the regions is being raised.
 The main reason for the reform is the desire to reduce the powers of the President and transfer part of them to the Parliament, so that the next President is no longer endowed with virtually absolute power, and, in turn, can not initiate another reform without the approval of all branches of government.
 The author of the article identifies the reasons for the political reform and gives forecasts for the future after its implementation.
 Conclusions. The author links these changes to the upcoming transfer of presidential power after 2024. The reform does not mean the transition of the Russian Federation to a parliamentary republic, since the head of state retains the status of a key figure in the po-litical system, and it is he who has concentrated key functions. Fixing a number of social obligations in the Constitution in terms of salaries and pensions will not have a significant impact on the socio-economic situation.
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Pinheiro, Izoldi Klein, Dilva Bertoldi Benvenutti, and Jacir Favretto. "Ambiente de aprendizagem: conhecimento tecnológico pedagógico do conteúdo (Learning environment: technological pedagogical content knowledge)." Revista Eletrônica de Educação 14 (March 3, 2020): 3765070. http://dx.doi.org/10.14244/198271993765.
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The reflections are part of the Master's Dissertation entitled Integration of digital media in basic education for the study of sustainability, Professional Master in Business Administration from Unoesc, Chapecó (Brazil). The research aims to understand the TPACK structure and its relationship to the process of teaching and learning in the context of the classroom. The research addresses the integration of digital media in the teaching-learning process, allowing the student to learn in a healthy, pleasurable, meaningful and innovative way. The structure is based on Koehler and Mishra (2009), who touted the need for teachers to understand pedagogically the inclusion of technologies in the context of the classroom. The study was developed through qualitative research, using semi-structured interviews with teachers of the Education Network of a municipality located in the Santa Catarina’s State, characterized as a case study. As for its nature, the research is classified as applied and based on its objectives, the study can be considered descriptive. The dice were analyzed by content technique analysis. Among the main results, it is identified that teachers use digital media available in schools, but present traditional postures where the student becomes a passive being. In schools where digital media integration occurs, work depends on the computer teacher. Some teachers yearn for the integration of technological resources in teaching practice, however, they need training.ResumoAs reflexões fazem parte da Dissertação de Mestrado intitulada Integração das novas tecnologias na Educação Básica para o estudo da sustentabilidade, Mestrado profissional em Administração da Unoesc, Campus Chapecó. A pesquisa objetiva entender a estrutura TPACK e sua relação com o processo de ensinar e aprender no contexto da sala de aula. A pesquisa aborda a integração das mídias digitais no processo ensino aprendizagem, permitindo o aluno aprender de maneira saudável, prazerosa, significativa e inovadora. A estrutura se fundamenta em Koehler e Mishra (2009), que apregoa a necessidade dos docentes compreenderem pedagogicamente a inclusão das tecnologias no contexto da sala de aula. O estudo foi desenvolvido por meio de pesquisa qualitativa, utilizando entrevista semi-estruturada com professores da Rede de Ensino de um Município localizado no Estado de Santa Catarina, caracterizando-se como estudo de caso. Quanto à sua natureza, a pesquisa se classifica como aplicada e com base nos seus objetivos, o estudo pode ser considerado descritivo. Os dados foram analisados pela técnica de análise de conteúdo. Dentre os principais resultados, identifica-se que os docentes utilizam as mídias digitais disponíveis nas escolas, porém apresentam posturas tradicionais onde o aluno se torna um ser passivo. Nas escolas onde ocorre integração das mídias digitais, o trabalho depende do professor de informática. Alguns docentes anseiam pela integração de recursos tecnológicos na prática docente, contudo, necessitam de formação.SommarioLe riflessione che seguono sono parte della Dissertazione del Master intitolata integrazione dei media digitale nell’istruzione di base e studio della sostenibilità, Master professionale in Amministrazione dell’ Unoesc, Chapecó (Brasile). La ricerca ha l’obiettivo di comprendere la struttura TPACK e la sua relazione con il processo di insegnamento e apprendimento nel contesto della classe. La ricerca tratta dell’introduzione dei media digitale nel processo d’istruzione, dando la possibilità all’alunno di imparare di forma salutare e piacevole, significativa e innovativa. La struttura si basa negli studi di Koehler e Mishra (2009), che evidenziano la necessità di comprendere dal punto di vista della didattica il ricorso alle nuove tecnologie nel contesto della classe da parte dei docenti. Lo studio è stato realizzato per mezzo di ricerca qualitativa, utilizzando intreviste semi-strutturate con professori della rete d’istruzione di un Municipio localizzato nello Stato di Santa Catarina, si caratterizza come studio di caso. Per quanto riguarda la sua natura, la ricerca si classifica come applicata e con base nei suoi obiettivi, lo studio può essere considerato descritivo. I dati sono stati analizzati con la tecnica di analise de contenuto. Tra i principali risultati, si ha identificato che i docenti fanno ricorso ai media digitali disponibili nelle scuole, però ricorrono ad approcci tradizionali ai quali l’alunno diventa un essere passivo. Nelle scuole dove occorre l’introduzione dei media digitali, il lavoro dipende dal professore di informatica. Alcuni docenti attendono per l’inserimento di strumenti tecnologici nella pratica dell’insegnamento, tuttavia, hanno necessità di formazione.Palavras-chave: Mídias digitais, Aprender, Ensinar, Conhecer.Keywords: Digital media, Learn, Teach, To know.Parole chiavi: Media digitali, Apprendere, Insegnare, Conoscere.ReferencesASSMANN, Hugo. A metamorfose do aprender na sociedade da informação. Ci. Inf., Brasília, v. 29, n. 2, p. 7-15, maio/ago. 2000. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-19652000000200002&lng=en&nrm=iso>. Acesso em: 12 jan. 2017.BENVENUTTI, Dilva B. Avaliação nos processos de aprendizagem. Curitiba: Prismas, 2017.CARROLL, Lewis. Alice no País das Maravilhas. São Paulo: Martin Claret, 2007. Título original em inglês: Alice’s Adventures in Wonderland (1866).CLOSS, Lisiane Quadrado; ANTONELLO, Claudia Simone. Teoria da aprendizagem transformadora: contribuições para uma educação gerencial voltada para a sustentabilidade. Revista de Administração Mackenzie, v. 15, n. 3, p. 221-252, 2014. Disponível em: http://www.spell.org.br/documentos/ver/31872/teoria-da-aprendizagem-transformadora--contribuicoes-para-uma-educacao-gerencial-voltada-para-a-sustentabilidade. Acesso em: 13 fev. 2018.DEMO, Pedro. Educação hoje: “novas” tecnologias, pressões e oportunidades. São Paulo: Atlas, 2009.GABRIEL, Martha. Educ@r: a (r)evolução digital na educação. São Paulo: Saraiva, 2013.KENSKI, Vani Moreira Educação e tecnologias: o novo ritmo da informação. 8.ed. Campinas, SP: Papirus, 2012.KOEHLER, Matthew J.; MISHRA, Punya. What is technological pedagogical content knowledge? Contemporary Issues in Technology and Teacher Education, v.9, n.1, p. 60-70, 2009. Disponível em: http://www.citejournal.org/volume-9/issue-1-09/general/what-is-technological-pedagogicalcontent-knowledge. Acesso em: 01 jan. 2017.KONDRAT, Hebert; MACIEL, Maria de Lourdes. Educação ambiental para a escola básica: contribuições para o desenvolvimento da cidadania e da sustentabilidade. Revista Brasileira de Educação, v. 18, n. 55, p. 825-846, 2013.MAZON, Michelle Juliana Savio. TPACK (Conhecimento Pedagógico de Conteúdo Tecnológico): Relação com as diferentes gerações de professores de Matemática. Universidade Estadual Paulista, 2012. 124f. Dissertação (Mestrado Educação para a Ciência). Universidade Estadual Paulista. Bauru – SP, 2012. Disponível em: http://www2.fc.unesp.br/BibliotecaVirtual/DetalhaDocumentoAction.do?idDocumento=511#. Acesso em: 12 fev. 2018.MONEREO, C.; POZO, J. I. O aluno em ambientes virtuais: condições, perfil e competências. In: COLL, C.; MONEREO, C. Psicologia da educação virtual: aprender e ensinar com as tecnologias da informação e da comunicação. Porto Alegre: Artmed, 2010.NOGUEIRA, Fernanda; PESSOA, Teresa; GALLEGO, Maria-Jesus. Desafios e oportunidades do uso da tecnologia para a formação contínua de professores: uma revisão em torno do TPACK em Portugal, Brasil e Espanha. # Tear: Revista de Educação Ciência e Tecnologia, Canoas, v.4, n.2, 2015. Disponível em: https://periodicos.ifrs.edu.br/index.php/tear/article/view/1950. Acesso em: 12 fev. 2018.PRENSKY, Marc. Digital Natives, Digital Immigrants. Horizon NCB University Press, v. 9, n. 5, Out. 2001. Disponível em: http://www.marcprensky.com/writing/Prensky%20-%20Digital%20Natives,%20Digital%20Immigrants%20-%20Part1.pdf. Acesso em: 25 jan. 2018.ROMAN, Darlan José; FERREIRA, Maristela. Mapeamento da Produção Científica sobre Educação para a Sustentabilidade no período de 2005 a 2015. In: XL ENCONTRO DA ANPAD. 2016, Costa do Sauipe – BA.SCHÖN, Donald. A. Educando o profissional reflexivo: um novo design para o ensino e a aprendizagem. Trad. Roberto Cataldo Costa. Porto Alegre: Artmed, 2000.SEVERINO, Antonio Joaquim. Metodologia do Trabalho Científico. 22 a ed. São Paulo: Cortez, 2002.VALENTE, J. A. Uso da internet em sala de aula. Educ. rev., Curitiba, n. 19, p. 131-146, jun. 2002 . Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-40602002000100010&lng=en&nrm=iso>. Acesso em: 21 jan. 2017.VALENTE, José Armando. As tecnologias e a verdadeira inovação. Pátio – Ensino Fundamental. Porto Alegre, Artmed, v.14, n. 56, p. 6-9, Jan. 2011.WESTON, Mark. E.; BAIN, Alan. The Endof Techno-Critique: The Naked Truthabout 1:1 Laptop Initiatives and Educational Change. Journal of Technology, Learning, and Assessment. v. 9, n. 6, 2010.Disponível em: http://ejournals.bc.edu/ojs/index.php/jtla/issue/view/15. Acesso em: 29 dez. 2016.e3765070
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Ghezzi, Carlo. "ASPETTI ETICI DELLA RICERCA E DELL’INNOVAZIONE TECNOLOGICA: IL CASO DELL’INFORMATICA | MONDI VIRTUALI, RETI SOCIALI, SISTEMI AUTONOMI “INTELLIGENTI”." Istituto Lombardo - Accademia di Scienze e Lettere - Incontri di Studio, November 12, 2019. http://dx.doi.org/10.4081/incontri.0.566.
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Advances in research and technological innovations in Informatics are revolutionizing our society. We already live in a cyber-physical world: interaction and collaboration among humans occurs seamlessly both in physical and in virtual spaces and virtual agents automate tasks at all levels, including those that traditionally relied on human intelligence. Access to data and information is available to everybody, anywhere and at any time, eliminating barriers but also generating potential distorted usage. Whatever humans do is inevitably mediated by technology, which potentially invades the private sphere of individuals. Changes are happening so fast and their effects are so spectacular that their ethical implications are often understood too late or underestimated. This contribution briefly introduces the disruptive changes produced by advances in Informatics and their severe ethical implications. It argues that an interdisciplinary effort is needed to focus on ethical issues while research and innovation are developed rather than as an after-the-fact reflection.
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Ghezzi, Carlo. "ASPETTI ETICI DELLA RICERCA E DELL’INNOVAZIONE TECNOLOGICA: IL CASO DELL’INFORMATICA | MONDI VIRTUALI, RETI SOCIALI, SISTEMI AUTONOMI “INTELLIGENTI”." Istituto Lombardo - Accademia di Scienze e Lettere - Incontri di Studio, November 12, 2019. http://dx.doi.org/10.4081/incontri.2019.566.
Full textAbstract:
Advances in research and technological innovations in Informatics are revolutionizing our society. We already live in a cyber-physical world: interaction and collaboration among humans occurs seamlessly both in physical and in virtual spaces and virtual agents automate tasks at all levels, including those that traditionally relied on human intelligence. Access to data and information is available to everybody, anywhere and at any time, eliminating barriers but also generating potential distorted usage. Whatever humans do is inevitably mediated by technology, which potentially invades the private sphere of individuals. Changes are happening so fast and their effects are so spectacular that their ethical implications are often understood too late or underestimated. This contribution briefly introduces the disruptive changes produced by advances in Informatics and their severe ethical implications. It argues that an interdisciplinary effort is needed to focus on ethical issues while research and innovation are developed rather than as an after-the-fact reflection.
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Nunes, Filipe Sales, Amanda Alves Fecury, Carla Viana Dendasck, and Claudio Alberto Gellis de Mattos Dias. "Accessibilità a Internet in Brasile negli anni 2008 e 2016." Revista Científica Multidisciplinar Núcleo do Conhecimento, September 26, 2018, 47–54. http://dx.doi.org/10.32749/nucleodoconhecimento.com.br/tecnologia-it/accessibilita-a-internet.
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Internet è il nodo di più reti di comunicazione, su scala globale che interconnettono reti dai più diversi luoghi del mondo. È popolare in tutto il mondo, a cui accedono più di 2 miliardi di utenti. L’obiettivo di questo lavoro è dimostrare il cambiamento nell’accessibilità di Internet in Brasile durante gli anni 2008 e 2016. A tale scopo, è stata effettuata una ricerca nel database CETIC sul sito web (http://cetic.br/). La percentuale di persone che hanno avuto accesso a Internet negli ultimi 9 anni è quasi raddoppiata, raggiungendo il 69% nel 2016, con un aumento del 30% rispetto al 2008. Nel 2014 il governo del Brasile insieme alla maggioranza delle società di telecomunicazioni nel paese, hanno deciso di aumentare la copertura della banda larga fissa e di Internet mobile. Le classi sociali inferiori C e DE, negli anni 2008 e 2016, hanno ottenuto un aumento del 30% della percentuale di accesso a Internet. Il sud-est è una delle regioni che più contiene l’accesso a Internet in Brasile. Il telefono cellulare è anche uno dei mezzi considerati per l’accesso a casa, poiché più della metà della popolazione brasiliana utilizza questo dispositivo per accedere a Internet. È evidente che più brasiliani hanno la possibilità di accedere a Internet in Brasile. A causa di diversi fattori, come i piani creati dal governo per aumentare l’accesso nel paese, tale iniziativa può essere considerata di estrema importanza nel progresso di diverse aree del Brasile. L’accesso a Internet è in grado di migliorare l’economia e l’istruzione nel Paese, oltre alla vita della popolazione che può più facilmente godere di nuovi mezzi di interazione attraverso piattaforme virtuali. L’accessibilità all’accesso a Internet in Brasile è aumentata e ha generato migliori cambiamenti per la vita dei suoi utenti.
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Giudice da Silva Cezar, Bibiana, and Kathiane Benedetti Corso. "EU NAVEGO, TU NAVEGAS E NÓS DEVERÍAMOS ESTAR TRABALHANDO: UM ESTUDO NETNOGRÁFICO DA MANIFESTAÇÃO DO CYBERLOAFING NAS INTERAÇÕES SOCIAIS ONLINE." Revista Eletrônica de Sistemas de Informação 17, no. 3 (2019). http://dx.doi.org/10.21529/resi.2018.1703002.
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Em um contexto organizacional cada vez mais digital e tecnológico, pode-se perceber de maneira recorrente o cyberloafing: o uso das TICs no âmbito laboral para fins pessoais, não pertinentes ao trabalho. Esse fenômeno pode ser exemplificado em diversas práticas, em especial, o acesso a redes sociais virtuais no ambiente de trabalho para fins não profissionais. O objetivo geral da presente pesquisa foi compreender o cyberloafing através do engajamento nas interações online entre usuários da rede social virtual Reddit. Para tal, realizou-se uma netnografia de abordagem qualitativa mediante imersão na comunidade Reddit r/brasil. Procedeu-se a uma análise documental, reunindo conteúdo produzido pelos membros da comunidade sem interferência das pesquisadoras, e a uma observação participante, realizando comentários ou postagens que incentivassem o(s) informante(s) a se manifestar sobre suas experiências de cyberloafing. Consideraram-se como manifestações os relatos específicos sobre o fenômeno ou acerca de qualquer outra questão relacionada. Verificou-se uma grande frequência de práticas de cyberloafing grave, além de manifestações acerca de antecedentes organizacionais e individuais. Apesar de se identificar consequentes positivos, os consequentes negativos sobressaíram. Quanto aos posicionamentos organizacionais em relação ao uso pessoal de TICs, identificaram-se o restritivo e o permissivo. Verificaram-se, em maior número, manifestações de estratégias ou medidas de controle coercitivas. Considera-se que a pesquisa traz consigo relevância visto que apresenta o cyberloafing de maneira ampla, manifestado espontaneamente por seus praticantes, em um ambiente virtual favorável para a ocorrência do fenômeno.
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Duizith, José Luiz Andrade, Lizandro Kirst Da Silva, Daniel Ribeiro Brahm, Gustavo Tagliassuchi, and Stanley Loh. "A Virtual Assistant for Websites." Revista Eletrônica de Sistemas de Informação 3, no. 1 (2004). http://dx.doi.org/10.21529/resi.2004.0301002.
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This work presents a Virtual Assistant (VA) whose main goal is to supply information for Websites users. AVA is a software system that interacts with persons through a Web browser, receiving textual questions and answering automatically without human intervention. The VA supplies information by looking for similar questions in a knowledge base and giving the corresponding answer. Artificial Intelligence techniques are employed in this matching process, to compare the user’s question against questions stored in the base. The main advantage of using the VA is to minimize information overload when users get lost in Websites. The VA can guide the user across the web pages or directly supply information. This is especially important for customers visiting an enterprise site, looking for products, services or prices or needing information about some topic. The VA can also help in Knowledge Management processes inside enterprises, offering an easy way for people storing and retrieving knowledge. An extra advantage is to reduce the structure of Call Centers, since the VA can be given to customers in a CD-ROM. Furthermore, the VA provides Webmasters with statistics about the usage of the VA (themes more asked, number of visitants, time of conversation).
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Pagès, Nicolas, and Monique Noirhomme-Fraiture. "The Problem Frames Approach to a Virtual Laboratory Conception." Revista Eletrônica de Sistemas de Informação 5, no. 1 (2006). http://dx.doi.org/10.21529/resi.2006.0501007.
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This paper presents a virtual laboratory’s conception. It is based on the problem frames approach and involves tke adaptation to computer assisted learning environments. It enphasizes the necessity of defining a certain number of new problem frames in order to adapt it to a learning environment, and particularly to simulations. We present the application of this conception method to the SAI project.
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Caetano da Silva, Cintia Ramalho, Thiago Cortat Tavares, Ana Cristina Bicharra Garcia, and Jose Luiz Thomasseli Nogueira. "ESPAÇO REUNI - UMA INICIATIVA DE E-GOV EM MUNDOS VIRTUAIS 3D." Revista Eletrônica de Sistemas de Informação 8, no. 1 (2009). http://dx.doi.org/10.5329/resi.2009.0801002.
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Dolci, Pietro Cunha, and Alexandre Reis Graeml. "EDITORIAL." Revista Eletrônica de Sistemas de Informação 15, no. 2 (2016). http://dx.doi.org/10.21529/resi.2016.150201.
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Editorial do v. 15, n. 2Nesta segunda edição de 2016 (v. 15, n. 2), a RESI traz quatro artigos, dois deles na seção Foco na tecnologia, um na seção Foco nas pessoas e um na seção E-gov no Brasil.São eles:UMA ABORDAGEM METODOLÓGICA PARA A IMPLEMENTAÇÃO MULTI-MODELOS DE QUALIDADE DE SOFTWARE ADOTANDO A CERTICS E O CMMI-DEV, de Sandro Ronaldo Bezerra Oliveira, Fabrício Wickey da Silva Garcia e Clênio Figueiredo Salviano, PROBLEM-BASED SOFTWARE REQUIREMENTS SPECIFICATION, de Rafael Gosrki M. de Souza e Paulo Cézar Stadzisz, INTERAÇÕES ESPONTÂNEAS EM AMBIENTE VIRTUAL DE APRENDIZAGEM POR MEIO DE DISPOSITIVOS MÓVEIS: UM MAPEAMENTO BASEADO NA ANÁLISE DE REGISTROS DE ACESSO AO SISTEMA, de Ana Luisa Mülbert e Osmar de Oliveira Braz Junior e ANÁLISE DO NÍVEL DE ABERTURA DE DADOS GOVERNAMENTAIS DA ÁREA DO TRÂNSITO NO BRASIL, de Ricardo Matheus, Denis Rodrigues, José Carlos Vaz e Martin Jayo.Tenham todos uma ótima leitura!
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Oldoni, Alisson, Anita Maria da Rocha Fernandes, and Janice Inês Deters. "Desenvolvimento de uma arquitetura de comunicação de um agente pedagógico inteligente em Java." Revista Eletrônica de Sistemas de Informação 6, no. 1 (2009). http://dx.doi.org/10.21529/resi.2007.0601004.
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O projeto “Sistemas Virtuais de Ensino Baseados na Internet para Suporte à Educação e Treinamento na Área de Saúde”, coordenado pelo Instituto de Engenharia Biomédica da Universidade Federal de Santa Catarina, engloba o desenvolvimento de um Sistema Tutor Inteligente de neurofisiologia que utiliza a tecnologia de agentes pedagógicos inteligentes. O estudo realizado para a escolha da ferramenta de sistema especialista baseado em regras a ser utilizada na inteligência do agente não é uma tarefa trivial e constituiu uma das partes mais fundamentais da modelagem do projeto. Este artigo apresenta este estudo das ferramentas, a ferramenta escolhida e a arquitetura de comunicação desenvolvida.
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Ishisaki, Bruno Yukio Meireles, and Denise H. L. Garcia. "O Desvio no Fluxo Composicional." Musica Theorica 4, no. 1 (2019). http://dx.doi.org/10.52930/mt.v4i1.79.
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Neste texto buscamos compreender, no contexto dos processos criativos em composição musical, as características do desvio no fluxo composicional a partir da perspectiva do virtual deleuziano. Acreditamos que a manifestação do desvio é um acontecimento inevitável dentro do fluxo criativo que, ao produzir diferença por meio da atualização, promove uma dessemelhança entre o que é criado e o que é pensado. Neste caso, a atualização contribuiria para um processo mais espiralar do que linear, em oposição à imagem do fluxo criativo como um trajeto teleológico em linha reta (que iria das ideias para os estados de coisas).
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Garcia, Daniella de Araújo, and Carlo Gabriel Porto Bellini. "PARTICIPAÇÃO EM REDES SOCIAIS VIRTUAIS SOB A ÓTICA DAS TEORIAS DA AÇÃO: INVESTIGAÇÃO ETNOGRÁFICA PRELIMINAR SOBRE A IDENTIDADE DE ESTUDANTES DE ADMINISTRAÇÃO." Revista Eletrônica de Sistemas de Informação 8, no. 2 (2009). http://dx.doi.org/10.5329/resi.2009.0802007.
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Medina, Nelkis De la Orden. "Palavras do editor." Revista Eletrônica de Sistemas de Informação 3, no. 1 (2009). http://dx.doi.org/10.21529/resi.2004.030101.
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Neste exemplar, de número um do terceiro ano da Revista Eletrônica de Sistemas de Informação, temos uma variada gama de artigos, bastante interessantes. No artigo “Reconhecimento de Voz para Automação Residencial baseado em Agentes Inteligentes”, Marília A. Amaral e Eduardo Cotrin Teixeira descrevem o desenvolvimento de um software de reconhecimento de voz para automação residencial que utiliza arquitetura baseada em agentes inteligentes e que tem como objetivo auxiliar e proporcionar mais independência a pessoas portadoras de necessidades especiais. José Luiz Andrade Duizith, Lizandro Kirst da Silva, Daniel Ribeiro Brahm, Gustavo Tagliassuchi e Stanley Loh apresentam um software assistente virtual para websites que permite a interação com os usuários através do browser, recebendo perguntas em forma de texto e respondendo automáticamente sem aintervenção humana. No artigo “A Virtual Assistant for Websites” descrevem também as técnicas de inteligência artificial empregadas no software. O artigo “A Strategy for Selecting Classes of Symbols from Classes of Graphemes in HMM-Based Handwritten Word Recognition”, de Cinthia O. A. Freitas, Flávio Bortolozzi e Robert Sabourin, descreve uma metodologia para seleção de classes de símbolos a partir de classes de grafemas em um sistema de reconhecimento de palavras manuscritas do extenso de cheques bancários brasileiros baseado em HMM (Hidden Markov Models). O artigo discute as definições de primitivas, grafemas e símbolos considerando um enfoque Global para o reconhecimento das palavras. Nelson D. A. Mascarenhas, Hanumant S. Sawant, Célio E. Morón, Reinaldo R. Rosa, José H. Saito, Hélio C. Guardia e Lilian N. Faria, no artigo “Solar Images Processing in Parallel Environment” relatam o projeto PVA-BDA (Processing, Visualization and Analysis in Parallel Environment of the BDA Data) para processar imagens solares que está sendo desenvolvido pelo Departamento de Ciência da Computação da Universidade Federal de São Carlos. “Uma Abordagem para o Processo de Gerenciamento de Configuração de Software” é uma contribuição de João Ronaldo Del Ducca Cunha, Antonio Francisco do Prado e Antonio Carlos dos Santos, neste trabalho os autores descrevem uma abordagem para o processo de GCS, definindo atividades que buscam atender a área de processo de Gerenciamento de Configuração do modelo CMMI. Em “Metodologias Ágeis Extreme Programming e Scrum para o Desenvolvimento de Software” de Michel dos Santos Soares, o autor apresenta as vantagens das metodologias ágeis para desenvolvimento de software em relação às metodologias tradicionais. São apresentadas as principais características das metodologias ágeis Extreme Programming e Scrum. Rafael Kunst e Vinicius Gadis Ribeiro no artigo “Implementação do Esquema de Criptografia de Chave Pública Rafaella” apresentam os aspectos históricos da criptografia e descrevem a implementação de um esquema de chave pública chamado Rafaella. O último artigo “Dedalus – Educação a Distância e Inclusão Digital através de Aplicações Auto-Hospedadas” de Dalila Paiva, Danielle Parga e Carlo Tola Oliveira descreve uma plataforma federada que consiste de uma rede de sites gráficos onde um usuário pode reunir e veicular suas informações com pouco conhecimento tecnológico. Todos os artigos trazem uma grande contribuição e enriquecem o acervo de trabalhos publicados na revista RESI. Estes trabalhos mostram a qualidade dos trabalhos de pesquisa que vem sendo desenvolvidos no Brasil. Aproveitamos para agradecer a todos os membros do conselho editorial e ao corpo de revisores que continuam colaborando ativamente com a revista, assim como os autores dos trabalhos publicados nesta edição que tornaram possível a publicação da mesma. Campo Largo, novembro de 2004. Nelkis de la Orden Medina Editora-Chefe
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Medina, Nelkis De la Orden. "Palavras do editor." Revista Eletrônica de Sistemas de Informação 4, no. 1 (2009). http://dx.doi.org/10.21529/resi.2005.040101.
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É com satisfação que apresentamos a edição 5 da Revista Eletrônica de Sistemas de Informação. Os trabalhos apresentados constituem um meio de divulgação das pesquisas e reflexões sobre diferentes temáticas da área de informática. Fazem parte desta edição cinco artigos, abordando assuntos relacionados à multimídia, gestão do conhecimento, gestão de projetos e informática aplicada à medicina. Rogério Kinape e Mardson Amorim nos trazem o artigo “A study of the most important image quality measures” que apresenta uma discussão sobre as medidas de qualidade de imagem quanto ao seu desempenho. Andréa Sabedra Bordin e Renato Balancieri são os autores do trabalho “Proposta de uma Arquitetura de Agentes Móveis para Recuperação de Informação Útil e Distribuída no Processo de Gestão do Conhecimento”, no qual apresentam uma proposta para a utilização de uma arquitetura de agentes móveis no processo de gestão do conhecimento. No artigo “Técnicas de Animação em Ambientes Tridimensionais” os autores Walter Dutra da Silveira Neto e Adrei Krepsky apresentam um estudo dos princípios fundamentais de animação aplicados a um ambiente virtual de animação tridimensional. O artigo “Limitações das Atuais Soluções em Software: Uma Visão para Desenvolvimento de Ferramentas em Gestão de Projetos” dos autores Dani Juliano Czelusniak, Alessandro de Oliveira Binhara, Carlos Eduardo Yamasaki Sato, Dario Eduardo do Amaral Dergint e Luiz Alberto Pilatti apresenta um estudo que visa verificar as atuais limitações dos softwares de auxílio ao gestor de projetos, demonstrando como novas tecnologias de desenvolvimento de software podem contribuir para a construção de ferramentas mais eficazes. O quinto artigo de Osmir Kmeteuk Filho e Carolina Richter Anacleto, “Telemedicina: possibilidades versus realidade” apresenta um estudo das necessidades tecnológicas para a aplicação da telemedicina. Estes artigos enriquecem o acervo de trabalhos publicados na revista RESI e mostram o panorama das pesquisas que estão sendo desenvolvidas no país. Campo Largo, maio de 2005. Nelkis de la Orden Medina Editora-Chefe