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Journal articles on the topic 'Rosiglitazone maleate'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Havele, Shweta, and Sunil Dhaneshwar. "Determination of glibenclamide, metformin hydrochloride and rosiglitazone maleate by reversed phase liquid chromatographic technique in tablet dosage form." Chemical Industry and Chemical Engineering Quarterly 20, no. 1 (2014): 39–47. http://dx.doi.org/10.2298/ciceq120607101h.

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A simple, precise and accurate high performance liquid chromatography (HPLC) method was developed for the simultaneous estimation of metformin hydrochloride, rosiglitazone maleate, glibenclamide present in multicomponent dosage forms. Chromatography was performed on a 25 cm ? 4.6 mm i.d., 5-?m particle, C18 column with 78:22 (v/v) methanol: 20 mM potassium dihydrogen phosphate buffer as mobile phase at a flow rate of 1.0 ml/min and UV detection at 238 nm for metformin hydrochloride, rosiglitazone maleate, and glibenclamide. The total elution time was shorter than 9 min. This method was found t

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2

Spasov, A. A., V. A. Kosolapov, and N. I. Chepliaeva. "The antioxidative activity of oral hypoglycemic agents." Problems of Endocrinology 57, no. 4 (2011): 21–24. http://dx.doi.org/10.14341/probl201157421-24.

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Oral hypoglycemic agents, such as glibenclamide, gliclazide, metformin, rosiglitazone maleate, and diabenol, are known to exert in vitro a mild direct antioxidatove action. Rosiglitazone maleate showed moderate activity only on the hemiluminescence model with generation of active oxygen species while diabenol behaves as a scavenger of superoxide anion and hydroxyl radical in model hemiluminescence systems. Gliclazide exhibited dose-dependent activity only with respect to stable diphenyl-1-picrylhydrazyl (DPPG) radicals. Metformin and glibenclamide were inactive under in vitro conditions. It is

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3

Sorbera, L. A., X. Rabasseda, and J. Castañer. "Rosiglitazone Maleate < Prop INNM >." Drugs of the Future 23, no. 9 (1998): 977. http://dx.doi.org/10.1358/dof.1998.023.09.471185.

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4

Wu, Jiawei, Lixia Zhang, Xiangfeng Bu, Peng Li, Bing Zhao, and Yuan Tian. "Determination of the illegal adulteration of natural healthcare products with chemical drugs using surface-enhanced Raman scattering." Analyst 143, no. 21 (2018): 5202–9. http://dx.doi.org/10.1039/c8an01286e.

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5

Rupshee, Jain, K. Kashaw Sushil, Mishra P., and V. Kohli D. "Simultaneous spectrophotometric estimation of rosiglitazone maleate and glimepiride in tablets." Journal of Indian Chemical Society Vol. 84, Nov 2007 (2007): 1179–81. https://doi.org/10.5281/zenodo.5824824.

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Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India <em>E-mail </em>: sushilkashaw@gmail.com <em>Manuscript received 7 May 2007, revised 27 August 2007, accepted 29 August 2007</em> A new, simple, sensitive, accurate and reproducible spectrophotometric method was developed for the simultaneous estimation of rosiglitazone maleate and glimepiride in combine dosage form.

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6

Cuffini, Silvia L., Sonia Faudone, Maribel Ferro, María Teresa Garland, and Ricardo Baggio. "Rosiglitazone maleate 0.25-hydrate: a pseudopolymorphic form." Acta Crystallographica Section C Crystal Structure Communications 64, no. 3 (2008): o119—o122. http://dx.doi.org/10.1107/s0108270107054443.

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7

Krishna, Singamsetty Radha, Mandava Venkata Naga Brahmeshwar Rao, Tirmalaraju Satyanaryana Raju, Vurimidi Himabindu, and Ghanta Mahesh Reddy. "Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities." E-Journal of Chemistry 5, no. 3 (2008): 562–66. http://dx.doi.org/10.1155/2008/308724.

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Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the unknown impurities.

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8

Parashar, Ashish Kumar, Lalit Tyagi, and Vandana Arora Sethi. "Development and Evaluation of Raft-Forming Rosiglitazone Maleate Tablets for Enhanced Drug Delivery." Journal of Advanced Scientific Research 16, no. 03 (2025): 24–30. https://doi.org/10.55218/jasr.2025160305.

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This research aimed to enhance patient satisfaction by improving the absorption and effectiveness of Rosiglitazone Maleate. Floating tablets were developed using a raft-forming method. Compatibility assessments, including physical observation and FTIR analysis, confirmed minimal drug-polymer interaction. Nine formulations were prepared using varying ratios of HPMC K15M, Guar gum, Chitosan, sodium bicarbonate (effervescent agent), sodium alginate (viscous gel-forming agent), and MCC (diluent). The tablets were evaluated for weight variation (345.09 mg - 352.72 mg), hardness (< 5 kg/cm2), thi

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9

Senem anl, Senem anl, Seyfi Sardogan Seyfi Sardogan, and Ay e. zdemir and Bar Atalay Ay e zdemir and Bar Atalay. "Determination of Pka Values of Antidiabetic Drugs from Mobility Data and Pharmaceutical Analysis by Capillary Electrophoresis." Journal of the chemical society of pakistan 44, no. 4 (2022): 366. http://dx.doi.org/10.52568/001068/jcsp/44.04.2022.

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In this study, the dissociation constants of six antidiabetic drugs (rosiglitazon maleate, pioglitazone, glimepride, glibenclamide, gliclazide and glipizide) have been calculated by capillary electrophoresis (CE) technique in water from the mobilities of compounds at several pH values. The dissociation constant values of antidiabetics had been checked with the ones formerly decided withinside the literature and additionally with the statistics expected through the SPARC on-line calculator and ACDLAB. Also, easy, precise, green, accurate and completely validated CE technique for the analysis of

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10

Rao, M. R. P., S. G. Borate, K. C. Thanki, A. A. Ranpise, and G. N. Parikh. "Development and in vitro evaluation of floating rosiglitazone maleate microspheres." Drug Development and Industrial Pharmacy 35, no. 7 (2009): 834–42. http://dx.doi.org/10.1080/03639040802627421.

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11

Cheng, Alice YY, and Robert G. Josse. "Rosiglitazone maleate + metformin hydrochloride extend: review of an emerging compound." Expert Opinion on Investigational Drugs 18, no. 9 (2009): 1365–73. http://dx.doi.org/10.1517/13543780903143753.

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12

El-Naggar, Moustafa HM, Ahmed Helmy, Mahmoud Moawad, Mohamed Al-Omary, Yusuf Al-Kadhi, and Bassil Habib. "Late-Onset Rosiglitazone-Associated Acute Liver Failure in a Patient with Hodgkin's Lymphoma." Annals of Pharmacotherapy 42, no. 5 (2008): 713–18. http://dx.doi.org/10.1345/aph.1k543.

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Objective: To report a case of rosiglilazone-associated hepatotoxicity in a patient with Hodgkin's lymphoma. Case Summary: A 52-year-old man presented with low-grade fever and fatigue that had been present for 4 months. He had been receiving insulin for 5 years and rosiglitazone 4 mg/day for 11 months for control of type 2 diabetes; he was receiving no other drug therapy. During hospitalization, hepatotoxicity was shown, with abnormal liver function test results including alanine aminotransferase 488 U/L, aspartate aminotransferase 344 U/L, alkaline phosphatase B32 U/L, total bilirubin 4.61 mg

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13

Fahri, F. T., I. J. Clarke, D. W. Pethick, R. D. Warner, and F. R. Dunshea. "Rosiglitazone maleate increases weight gain and body fat content in growing lambs." Animal Production Science 56, no. 7 (2016): 1185. http://dx.doi.org/10.1071/an14885.

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Thiazolidinediones (TZD) are synthetic orally active peroxisome proliferator-activated receptor γ ligands used in the treatment of diabetes mellitus. The peroxisome proliferator-activated receptor γ gene plays an important role in regulating fat cell development, energy balance, and lipid metabolism in adipose and skeletal muscle tissue. There is interest in pharmacologic or nutritional means that may complement genetic techniques to improve growth and carcass composition of lambs and the major aim of the present study was to determine whether TZD impact on growth performance and meat quality

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14

Farah, Raymond. "Rosiglitazone Maleate and Metformin Hydrochloride in Fixed Combination: What Role in the Treatment of Type 2 Diabetes?" Clinical Medicine. Therapeutics 1 (January 2009): CMT.S2389. http://dx.doi.org/10.4137/cmt.s2389.

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Traditional first-line intervention in patients with type 2 diabetes and very poor glycemic control is insulin therapy or high doses of sulfanylureas if there is no evidence of volume depletion. This review assesses the efficacy and safety of rosiglitazone and metformin fixed dose combination (avandamet) as initial therapy in patients with uncontrolled type 2 diabetes. This combination therapy achieved significant reduction in A1c and fasting plasma glucose compared with either rosiglitazone or metformin monotherapy as demonstrated by various studies. This combination was generally well tolera

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15

Singhvi, I., and Anju Goyal. "Simultaneous spectrophotometric estimation of rosiglitazone maleate and glimepiride in tablet dosage forms." Indian Journal of Pharmaceutical Sciences 69, no. 6 (2007): 780. http://dx.doi.org/10.4103/0250-474x.39433.

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16

Cox, S. L. "Rosiglitazone maleate/metformin hydrochloride: A new formulation therapy for type 2 diabetes." Drugs of Today 40, no. 7 (2004): 633. http://dx.doi.org/10.1358/dot.2004.40.7.850480.

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17

Shaikh, S., M. S. Muneera, O. A. Thusleem, M. Tahir, A. V. Kondaguli, and K. Ruckmani. "Development and Validation of a Selective Online Dissolution Method for Rosiglitazone Maleate." Journal of Chromatographic Science 45, no. 6 (2007): 311–14. http://dx.doi.org/10.1093/chromsci/45.6.311.

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18

Xiong, Nanxiang, Fan Sun, Hongyang Zhao, and Jizhou Xiang. "Effect of Rosiglitazone Maleate on inflammation following cerebral ischemia/reperfusion in rats." Journal of Huazhong University of Science and Technology 27, no. 3 (2007): 295–98. http://dx.doi.org/10.1007/s11596-007-0320-x.

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19

Kirefu, Tabassum, Scott W. Landvatter, Alison J. Latter, Kenneth WM Lawrie, Donald J. Morecombe, and Kenneth Willcocks. "Rosiglitazone maleate (BRL 49653-C); the preparation of [14C] and [3H] isotopomers." Journal of Labelled Compounds and Radiopharmaceuticals 44, no. 5 (2001): 329–35. http://dx.doi.org/10.1002/jlcr.458.

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20

M, Alagusundaram, Priyanka Keshri, Mansi Tyagi, Nem Kumar Jain, Goli Venkateshwarlu, and Divya Gupta. "Formulation Development and Characterization of Floating Drug Delivery System of Rosiglitazone Maleate." Future Journal of Pharmaceuticals and Health Sciences 3, no. 3 (2023): 332–40. http://dx.doi.org/10.26452/fjphs.v3i3.488.

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In the current study, wet granulation with various concentrations and combinations of excipients like magnesium stearate as a lubricant, talc as glident, DCP as diluent, and PVP K 30 as a binder successfully produced floating tablets of rosiglitazone maleate. These excipients included HPMC K15M, xanthan gum, sodium bicarbonate, and tartaric acid as gas-generating agents. We investigated every pre-compressional parameter, including angle of repose, bulk density, and Carr's index. Drug content, hardness, friability, weight fluctuation, in-vitro dissolving experiments, floating qualities, and sta

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21

Singh, Vandana, and Dr Amrendra Kumar Chaudhary. "The Potential of TPP Chitosan Nanoparticles as Carrier for Poorly Soluble Rosiglitazone Maleate." International Journal of Pharmaceutical Sciences Review and Research 64, no. 2 (2020): 127–32. http://dx.doi.org/10.47583/ijpsrr.2020.v64i02.021.

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22

Walash, M. I., A. El-Brashy, N. El-Enany, and M. E. Kamel. "Spectrofluorimetric and spectrophotometric determination of rosiglitazone maleate in pharmaceutical preparations and biological fluids." Pharmaceutical Chemistry Journal 43, no. 12 (2009): 697–709. http://dx.doi.org/10.1007/s11094-010-0383-z.

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23

Güler, G. K., H. Eroğlu, and L. Öner. "Development and formulation of floating tablet formulation containing rosiglitazone maleate using Artificial Neural Network." Journal of Drug Delivery Science and Technology 39 (June 2017): 385–97. http://dx.doi.org/10.1016/j.jddst.2017.04.029.

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24

Giuseppe Derosa and Pamela Maffioli. "Rosiglitazone Maleate and Glimepiride in Fixed Combination for the Metabolic Control of Type 2 Diabetes." Clinical Medicine Reviews in Vascular Health 3 (2011): 31–38. http://dx.doi.org/10.4137/cmrvh.s1627.

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25

Satheesh Madhav, N. V., and Abhay Pratap Yadav. "A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate." Acta Pharmaceutica Sinica B 3, no. 6 (2013): 408–15. http://dx.doi.org/10.1016/j.apsb.2013.10.004.

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26

Singh, Rajeev K., and Pushpendra Sharma. "Simultaneous estimation of Rosiglitazone Maleate, Glimepride and Amlodipine Besylate in Tablet Dosage formulation by RP-HPLC." Research Journal of Pharmacy and Technology 10, no. 7 (2017): 2213. http://dx.doi.org/10.5958/0974-360x.2017.00391.2.

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27

Garud, Akanksha, and Navneet Garud. "Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique." Ars Pharmaceutica (Internet) 56, no. 2 (2015): 101–7. http://dx.doi.org/10.4321/s2340-98942015000200004.

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28

Rane, B. R., N. A. Gujarathi, and J. K. Patel. "Biodegradable anionic acrylic resin based hollow microspheres of moderately water soluble drug Rosiglitazone Maleate: preparation andin vitrocharacterization." Drug Development and Industrial Pharmacy 38, no. 12 (2012): 1460–69. http://dx.doi.org/10.3109/03639045.2011.653811.

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29

Bhende, Swati D., Murali Balaram Varanasi, and Konde Abbulu. "A Sensitive HPTLC Method for the Estimation of Glibenclamide, Rosiglitazone Maleate and Metformin Hydrochloride from a Multicomponent Dosage Form." Journal of Chromatographic Science 58, no. 5 (2020): 418–26. http://dx.doi.org/10.1093/chromsci/bmz124.

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Abstract A sensitive, rapid and cost-effective method based on HPTLC with UV detection was developed for the quantitation of Glibenclamide (GLIBEN), Rosiglitazone maleate (ROSI) and Metformin hydrochloride (MET) from a combined dosage form. Pre-coated RP-18 F254s aluminum sheets were used as the stationary phase. Methanol–tetrahydrofuran–water–glacial acetic acid (16: 3.6: 4: 0.4, v/v) used as the mobile phase, along with chamber saturation of 10 min offered an optimum migration (Rf = 0.54, 0.62 and 0.80 for GLIBEN, ROSI and MET, respectively). TLC Scanner 3 was used for densitometric evaluati

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30

Kamila, Madan Mohan, Nita Mondal, Lakshmikanta Ghosh, and Bijan Kumar Gupta. "Drug Dissolution Studies and Determination of Rosiglitazone Maleate in Tablets and Polymeric Microspheres by a Rapid, Validated RP-HPLC Method." Journal of Liquid Chromatography & Related Technologies 31, no. 16 (2008): 2503–16. http://dx.doi.org/10.1080/10826070802319800.

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31

Önal, Armağan. "Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparations." European Journal of Medicinal Chemistry 44, no. 12 (2009): 4998–5005. http://dx.doi.org/10.1016/j.ejmech.2009.09.003.

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32

Mohd-Radzman, Nabilatul Hani, Wan Iryani Wan Ismail, Siti Safura Jaapar, Zainah Adam, and Aishah Adam. "Stevioside fromStevia rebaudianaBertoni Increases Insulin Sensitivity in 3T3-L1 Adipocytes." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/938081.

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Stevioside fromStevia rebaudianahas been reported to exert antihyperglycemic effects in both rat and human subjects. There have been few studies on these effectsin vitro. In this paper, radioactive glucose uptake assay was implemented in order to assess improvements in insulin sensitivity in 3T3-L1 cells by elevation of glucose uptake following treatment with stevioside. Oil Red-O staining and MTT assay were utilized to confirm adipocyte differentiation and cell viability, respectively. Findings from this research showed a significant increase in absorbance values in mature adipocytes followin

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33

Farouk, Faten, Bahia Abbas Moussa, and Hassan Mohamed El-Said Azzazy. "Fourier transform infrared spectroscopy for in-process inspection, counterfeit detection and quality control of anti-diabetic drugs." Spectroscopy 26, no. 4-5 (2011): 297–309. http://dx.doi.org/10.1155/2011/975284.

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The purpose of this study is to develop simple and cost-effective Fourier transform infrared (FT-IR) methods for quality control evaluation of repaglinide (RPG), rosiglitazone maleate (RGZ), pioglitazone hydrochloride (PGZ) and metformin hydrochloride (MET) and assess their use for in-process quality control and detection of counterfeit medicine. The conventional KBr disc sampling technique used in FT-IR does not result in constant path-length thus impeding the use of this sensitive and simple technique for quantification of drugs. In this study, FT-IR quantitative assays were developed using

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34

Pawar, Uttam D., Aruna V. Sulebhavikar, Abhijit V. Naik, Satish G. Pingale, and Kiran V. Mangaonkar. "Simultaneous Determination of Rofecoxib and Tizanidine by HPTLC." E-Journal of Chemistry 6, no. 1 (2009): 295–302. http://dx.doi.org/10.1155/2009/674742.

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An innovative high performance thin layer chromatography method was developed and validated for simultaneous determination of rofecoxib and tizanidine from tablet dosage form. Rosiglitazone maleate was used as an internal standard. The separation was achieved using HPTLC plates (Merck #5548) precoated with silica gel 60F254on aluminum sheets and a mobile phase comprising of toluene: ethyl acetate: methanol: triethyl amine in volume ratio of 6:3:0.5:0.1 (v/v/v/v), with chamber saturation of 15 min. The plate was developed up to 8 cm and air dried. The plate was then scanned and quantified at 23

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35

Yu, Jia, Ke Ma, Jinwen Qi, et al. "Bioequivalence and comparison of pharmacokinetic properties of 4-mg tablet formulations of rosiglitazone hydrochloride and rosiglitazone maleate: A single-dose, randomized, open-label, two-period crossover study in healthy adult male Chinese volunteers." Clinical Therapeutics 30, no. 12 (2008): 2272–79. http://dx.doi.org/10.1016/j.clinthera.2008.12.011.

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36

Chappidi, Suryaprakash Reddy, Eranti Bhargav, Venkataranganna Marikunte, et al. "A Cost Effective (QbD) Approach in the Development and Optimization of Rosiglitazone Maleate Mucoadhesive Extended Release Tablets – In Vitro and Ex Vivo." Advanced Pharmaceutical Bulletin 9, no. 2 (2019): 281–88. http://dx.doi.org/10.15171/apb.2019.032.

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Purpose: The purpose of the study was to develop and optimize rosiglitazone maleate mucoadhesive extended-release tablets by quality by design (QbD) approach. Based on QTPP (quality target product profile) CQAs (critical quality attributes) were identified. Methods: Failure mode and effects analysis (FMEA) method were adopted for risk assessment. Risk analysis by the evaluation of formulation and process parameters showed that the optimizing the levels of polymers could reduce high risk to achieve target profile. Drug-excipient compatibility studies by Fourier transforms infra-red and DSC stud

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37

Vanderpoel, Daniel R., Mohamed A. Hussein, Teresa Watson-Heidari, and Andrew Perry. "Adherence to a fixed-dose combination of rosiglitazone maleate/metformin hydrochloride in subjects with type 2 diabetes mellitus: A retrospective database analysis." Clinical Therapeutics 26, no. 12 (2004): 2066–75. http://dx.doi.org/10.1016/j.clinthera.2004.12.018.

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38

Mahgoub, Hoda, Rasha M. Youssef, Mohamed A. Korany, Essam F. Khamis, and Miranda F. Kamal. "Development and validation of spectrophotometric and HPTLC methods for simultaneous determination of rosiglitazone maleate and metformin hydrochloride in the presence of interfering matrix excipients." Drug Development and Industrial Pharmacy 40, no. 9 (2013): 1190–98. http://dx.doi.org/10.3109/03639045.2013.810634.

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39

Winter, Carol L., Jana S. Lange, Michael G. Davis, et al. "A Nonspecific Phosphotyrosine Phosphatase Inhibitor, Bis(maltolato)oxovanadium(IV), Improves Glucose Tolerance and Prevents Diabetes in Zucker Diabetic Fatty Rats." Experimental Biology and Medicine 230, no. 3 (2005): 207–16. http://dx.doi.org/10.1177/153537020523000307.

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The molecular basis of insulin resistance, a major risk factor for development of Type II diabetes, involves defective insulin signaling. Insulin-mediated signal transduction is negatively regulated by the phosphotyrosine phosphatase, PTP1B, and numerous studies have demonstrated that organo-vanadium compounds, which are nonselective phosphotyrosine phosphatase inhibitors, have insulin-mimetic properties. However, whether or not vanadium compounds can prevent the transition from insulin resistance to overt diabetes is unknown. We compared the ability of bis(maltolato)oxovanadium(IV) (BMOV), an

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40

Garg, Meena, Manikkavasagar Thamotharan, Gerald Pan, Paul W. N. Lee та Sherin U. Devaskar. "Early exposure of the pregestational intrauterine and postnatal growth-restricted female offspring to a peroxisome proliferator-activated receptor-γ agonist". American Journal of Physiology-Endocrinology and Metabolism 298, № 3 (2010): E489—E498. http://dx.doi.org/10.1152/ajpendo.00361.2009.

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Prenatal nutrient restriction with intrauterine growth restriction (IUGR) alters basal and glucose-stimulated insulin response and hepatic metabolic adaptation. The effect of early intervention with insulin-sensitizing peroxisome proliferator-activated receptor γ agonists was examined in the metabolically maladapted F1 pregestational IUGR offspring with a propensity toward pregnancy-induced gestational diabetes. The effect of rosiglitazone maleate [RG; 11 μmol/day from postnatal day (PN) 21 to PN60] vs. placebo (PL) on metabolic adaptations in 2-mo-old F1 female rats subjected to prenatal (IUG

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41

Agrawal, Arvind, Maureen C. Sautter, and Nigel P. Jones. "Effects of rosiglitazone maleate when added to a sulfonylurea regimen in patients with type 2 diabetes mellitus and mild to moderate renal impairment: A post hoc analysis." Clinical Therapeutics 25, no. 11 (2003): 2754–64. http://dx.doi.org/10.1016/s0149-2918(03)80331-4.

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42

Ünal, Sevinç, and Memet Şimşek. "Comparision of Rosiglitazone Maleat Only Use with Combination with Clomiphene Citrate in Infertile Cases with Clomiphen Resistant Polycystic Ovary Syndrome Cases." İstanbul Kanuni Sultan Süleyman Tıp Dergisi, 2021. http://dx.doi.org/10.5222/iksstd.2021.87609.

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INTRODUCTION: Most of the obese PCOS patients are resistant to clomiphene citrate standard doses. In these cases metabolic syndromes are treated by using insulin sensitizing drugs so that ovulation can be achieved.In this study rosiglitazine maleat was used in order to induce ovulation in obese clomiphene resistant PCOS patients. METHODS: 30 women(18-40 year old) with clomiphene resistant polycystic ovary syndrome that were obese (BMI>25 kg/m2) and hyperinsulinemic were seperated in two groups. In the first group (n=15) oral antidiabetic Rosiglitazone maleate( 4mg bid) which belongs to thia

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43

"New Drugs: Rosiglitazone maleate." Australian Prescriber 24, no. 1 (2001): 20–23. http://dx.doi.org/10.18773/austprescr.2001.018.

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44

"Rosiglitazone maleate. Ketotifen fumarate." American Journal of Health-System Pharmacy 56, no. 19 (1999): 1924–26. http://dx.doi.org/10.1093/ajhp/56.19.1924.

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45

Pan, Yi, Junyang Li, Susu Lou, et al. "Down-Regulated miR-130a/b Attenuates Rhabdomyosarcoma Proliferation via PPARG." Frontiers in Molecular Biosciences 8 (February 4, 2022). http://dx.doi.org/10.3389/fmolb.2021.766887.

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Background: Rhabdomyosarcoma (RMS) is one of the most common types of soft-tissue sarcomas in children, and it exhibits a low 5-years survival rate. The survival outcome has shown no significant improvements in the past 30 years miRNA profiling of RMS might therefore provide a novel insight into uncovering new molecular targets for therapy.Methods: We analyzed miRNA and RNA sequencing data from patients and the TARGET database to reveal the potential miRNA-mRNA axes and validated them in patients’ samples. After the miRNA antagomirs were used to silence the target miRNAs in the cell model, qRT

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46

Alagusundaram, M., Keshri Priyanka, Tyagi Mansi, Kumar Jain Nem, Venkateshwarlu Goli, and Gupta Divya. "Formulation Development and Characterization of Floating Drug Delivery System of Rosiglitazone Maleate." July 26, 2023. https://doi.org/10.26452/fjphs.v3i3.488.

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In the current study, wet granulation with various concentrations and combinations of excipients like magnesium stearate as a lubricant, talc as glident, DCP as diluent, and PVP K 30 as a binder successfully produced floating tablets of rosiglitazone maleate. These excipients included HPMC K15M, xanthan gum, sodium bicarbonate, and tartaric acid as gas-generating agents. We investigated every pre-compressional parameter, including angle of repose, bulk density, and Carr's index. Drug content, hardness, friability, weight fluctuation, in-vitro dissolving experiments, floating qualities, and

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"RP-HPLC METHOD DEVELOPMENT AND ESTIMATION OF ROSIGLITAZONE MALEATE IN BULK AND TABLET DOSAGE FORM." International Journal of Biology, Pharmacy and Allied Sciences 10, no. 9 (2021). http://dx.doi.org/10.31032/ijbpas/2021/10.9.5604.

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Muratalla, Jose T., Samuel M. Lee, Pablo Remon-Ruiz, Gregory H. Norris, and Jose Cordoba-Chacon. "OR14-05 Hepatocyte Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Offsets the Anti-Steatogenic Effects of Thiazolidinediones in Obese Male Mice." Journal of the Endocrine Society 4, Supplement_1 (2020). http://dx.doi.org/10.1210/jendso/bvaa046.314.

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Abstract Pparg is a nuclear receptor that regulates glucose and lipid metabolism. Thiazolidinediones (TZD) are PPARG agonists that may reduce hepatic steatosis through their effects in adipose tissue. However, some studies suggest that expression and activation of hepatocyte Pparg promotes steatosis. In this study, we have assessed the relevance of hepatocyte Pparg, and its TZD-mediated activation in the development and/or reduction of steatosis, with adult-onset hepatocyte-specific Pparg knockout (PpargΔHep) mice. We reported that a single iv injection of AAV8-TBG-Cre in Pparg-floxed mice, kn

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Lee, Samuel M., Jose Muratalla, Alberto Diaz-Ruiz та ін. "Rosiglitazone Requires Hepatocyte PPARγ Expression to Promote Steatosis in Male Mice With Diet-Induced Obesity". Endocrinology 162, № 11 (2021). http://dx.doi.org/10.1210/endocr/bqab175.

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Abstract Thiazolidinediones (TZD) are peroxisome proliferator-activated receptor γ (PPARγ) agonists that may reduce hepatic steatosis through their effects in adipose tissue and therefore have been assessed as potential therapies to treat nonalcoholic fatty liver disease (NAFLD) in humans. However, some studies suggest that expression and activation of hepatocyte PPARγ promotes steatosis and that would limit the benefits of TZD as a NAFLD therapy. To further explore this possibility, we examined the impact of short-term rosiglitazone maleate treatment after the development of moderate or sever

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Mohan Kamila, Madan, Nita Mondal, Lakshmi Kanta Ghosh, and Bijan Kumar Gupta. "Multiunit Floating Drug Delivery System of Rosiglitazone Maleate: Development, Characterization, Statistical Optimization of Drug Release and In Vivo Evaluation." AAPS PharmSciTech 10, no. 3 (2009). http://dx.doi.org/10.1208/s12249-009-9276-4.

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