Academic literature on the topic 'S-methyl derivatives'

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Journal articles on the topic "S-methyl derivatives"

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Kaválek, Jaromír, Josef Jirman, and Vojeslav Štěrba. "Kinetics and mechanism of rearrangement and methanolysis of acylphenylthioureas." Collection of Czechoslovak Chemical Communications 50, no. 3 (1985): 766–78. http://dx.doi.org/10.1135/cccc19850766.

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S-Acyl-1-phenylthioureas and their 3-methyl derivatives are rearranged to 1-acyl derivatives of thiourea in methanolic solution. The rearrangement of the 1-acyl-1-phenyl derivative to the thermodynamically more stable 3-acyl derivative is subject to specific base catalysis. The rearrangement of acetyl group is about 2 orders of magnitude slower than that of benzoyl group. 1-Acetyl-l-phenylthiourea undergoes base-catalyzed methanolysis (giving phenylthiourea and methyl acetate) instead of the rearrangement. The methanolysis rates of l-acyl-3-phenylthioureas and their N-methyl derivatives have b
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Khalifa, Nagy M., Ahmed M. Naglah, Mohamed A. Al-Omara, and Abd El-Galil E. Amr. "Synthesis and Reactions of New Chiral Linear Dipeptide Candidates Using Nalidixic Acid as Starting Material." Zeitschrift für Naturforschung B 69, no. 6 (2014): 728–36. http://dx.doi.org/10.5560/znb.2014-4031.

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A series of dipeptide heterocyclic derivatives 4-15 were synthesized using methyl 2-{[(1-ethyl- 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]amino}-3-ethylbutanoate (3) as starting material. Treatment of 3 with L-phenylalanine methyl ester hydrochloride afforded the corresponding dipeptide methyl ester derivative 4, which was treated with hydrazine hydrate to afford the dipeptide acid hydrazide 5. Compound 5 was coupled with aldehyde and acetophenone derivatives to afford the corresponding Schiff bases 6a-f. The hydrazide derivative 5 was reacted with ethyl acetoacetate or acetone
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Patroni, JJ, RV Stick, BW Skelton та AH White. "The Selective Monobenzylidenation of Some Monosaccharides and Their Derivatives With α,α-Dimethoxytoluene". Australian Journal of Chemistry 41, № 1 (1988): 91. http://dx.doi.org/10.1071/ch9880091.

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The treatment of some monosaccharides and their derivatives with a,a-dimethoxytoluene and an acid catalyst in dimethylformamide at about 80° can lead to selective benzylidenation , e.g. methyl a-D- mannopyranoside gives mainly methyl 4,6-Obenzylidene-a-D-mannoside, together with two other minor monobenzylidene derivatives (2,3-) and two minor dibenzylidene derivatives (2,3:4,6-). The treatment of various other pyranoses and pyranosides is also described. As well, a 1H n.m.r . study of the acid transformation of some of the above α-D- mannosides is reported, together with a single-crystal X-ray
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Janeba, Zlatko, Antonín Holý, and Milena Masojídková. "Transformation of 8-[(2-Hydroxyalkyl)sulfanyl]adenines to 6-Amino-7H-purin-8(9H)-one Derivatives." Collection of Czechoslovak Chemical Communications 66, no. 9 (2001): 1393–406. http://dx.doi.org/10.1135/cccc20011393.

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Alkylation of 6-amino-7H-purin-8(9H)-thione (8-sulfanyladenine, 1) with one equivalent of (R)-[(trityloxy)methyl]oxirane gave its S-alkyl derivative 2, which was converted to the 6-amino-7H-purin-8(9H)-one (3), while alkylation of 1 with two equivalents of (S)-[(trityloxy)methyl]oxirane afforded a mixture of N3,S-dialkylated product 4a, N9-monoalkyl and N7,N9-dialkyl derivatives of 6-amino-7H-purin-8(9H)-one, 5a and 6a, respectively. This approach can be used for rapid and easy transformation of 8-[(2-hydroxyalkyl)sulfanyl]adenines to the derivatives of 6-amino-7H-purin-8(9H)-one (8-hydroxyade
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Mahyavanshi, Jyotindra, Snehal Lokhandwala, Jayesh Pandya, and Jigar Patel. "Synthesis, Structural Determination, Docking Study and Bioactivity of Novel Thiophene Derivatives." Asian Journal of Chemistry 36, no. 6 (2024): 1321–26. http://dx.doi.org/10.14233/ajchem.2024.31509.

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The present study reveals 4-methyl-3-(propylamino)thiophene-2-carboxylic acid (Articaine acid) as precursor derivative to synthesize novel thiophene compounds to evaluate their biological activity. The synthesized compounds were subjected to comprehensive characterization techniques including mass spectra, NMR and IR spectroscopy, confirming their structural integrity. Their antimicrobial activity was assessed via minimum inhibitory concentration (MIC) assay against selected bacterial strains. The results emphasize the potential therapeutic applications of these thiophene analogues as efficaci
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Lu, Shan, Siegfried Draeger, Barbara Schulz, et al. "Bioactive Aromatic Derivatives from Endophytic Fungus, Cytospora sp." Natural Product Communications 6, no. 5 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600518.

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Two new benzyl γ-butyrolactone analogues, ( R)-5-(( S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (1) and its 6-acetate (2), and a new naphthalenone derivative (8), together with eight additional known aromatic derivatives, ( S)-5-(( S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (3), ( S)-5-benzyl-dihydrofuran-2(3H)-one (4), 5-phenyl-4-oxopentanoic acid (5), γ-oxo-benzenepentanoic acid methyl ester (6), 3-(2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furyl)propionic acid (7), (3 R)-5-methylmellein (9), integracins A (10) and B (11) were isolated from Cytospora sp., an endophytic fungus isolate
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Lee, Yong Hoon, Hee Joo Jang, Kun Hee Park, et al. "Phytochemical Analysis of the Fruits of Sea Buckthorn (Hippophae rhamnoides): Identification of Organic Acid Derivatives." Plants 10, no. 5 (2021): 860. http://dx.doi.org/10.3390/plants10050860.

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Hippophae rhamnoides L. (Elaeagnaceae), commonly known as “Sea buckthorn” and “Vitamin tree”, is a spiny deciduous shrub whose fruit is known for its nutritional composition, such as vitamin C, and is consumed as a dietary supplement worldwide. As part of our ongoing efforts to identify structurally new and bioactive constituents from natural resources, the phytochemical investigation of the extract of H. rhamnoides fruits led to the isolation of one malate derivative (1), five citrate derivatives (2–6), and one quinate derivative (7). The structures of the isolated compounds were elucidated b
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Barmaki, Mohammad, Gulgaz Valiyeva, Abel A. Maharramovm, and Mirze M. Allaverdiyev. "Synthesis of 2,3-Dihydro-6-methyl-2-thiopyrimidin-4(1H)-one (6-Methylthiouracil) Derivatives and Their Reactions." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/176213.

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The synthesis and characterization of 2,3-dihydro-6-methyl-2-thioxopyrimidin-(1H)-one (I) and some of its derivatives has been performed in our lab. Ring-closing cyclization, as a result of the condensation of ethyl-3-oxobutanoate with thiourea in KOH in an ethanol medium produced 2,3-dihydro-6-methy -2-thioxopyrimidin-(1H)-one (I). The reaction of compound (I) with 2- chloroacetic acid in an alkaline KOH solution produced the carboxylate derivative, 2-(2,6-dihydro-4-methyl-6-oxopyrimidin-2-yl-thio)ethanoic acid (II). The reaction of the resulted derivative of carboxylate (II) with the salt of
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Glowacz-Czerwonka, Dorota. "Oligoetherols with S-Trazine Ring Based on Hydroxymethyl Derivatives of Methyl Ethyl Ketone." Chemistry & Chemical Technology 11, no. 1 (2017): 45–48. http://dx.doi.org/10.23939/chcht11.01.045.

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Lai, Chin-Hung, Chia-Chin Chang, Yi-Lin Weng, and Ta-Hsien Chuang. "Synthesis, Experimental and Density Functional Theory (DFT) Studies on Solubility of Camptothecin Derivatives." Molecules 23, no. 12 (2018): 3170. http://dx.doi.org/10.3390/molecules23123170.

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Two camptothecin derivatives, 10-cyclohexyl-7-methyl-20(S)-camptothecin and 7-methyl-10-morpholino-20(S)-camptothecin, were synthesized and their differences in solubility were investigated using four chosen solvent systems. Based on our results, 10-cyclohexyl-7-methyl-20(S)-camptothecin exhibited higher solubilities than 7-methyl-10-morpholino-20(S)-camptothecin in polar aprotic solvents. However, these two camptothecin derivatives did not exhibit apparent differences in solubility between 5% dimethyl sulfoxide (DMSO)/95% normal saline co-solvent system and 5% dimethylacetamide (DMAC)/95% nor
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Dissertations / Theses on the topic "S-methyl derivatives"

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Alemu, Yemataw Addis. "Synthesis, characterization and biological evaluation of zinc(ii) complexes with phenanthroline derivatives and s-methyl dithiocarbazate schiff bases." Master's thesis, 2017. http://hdl.handle.net/10400.1/10160.

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Dissertação de mestrado, Inovação Química e Regulamentação (Erasmus Mundus), Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2017<br>The discovery of novel active compounds with new mechanisms of action, higher efficacy and improved selectivity is a matter of urgency to multi drug resistance and toxicity problems associated with many therapeutic drugs. In the current work S-methyl dithiocarbazate Schiff base: SalSmdt, Mp(Smdt)2, VanSmdt, PySmdt and their Zn(II) complexes: Zn[(SalSmdt)(H2O)]0.5H2O, Zn2[(Mp(Smdt)2)(CH3COO)], Zn[(VanSmdt)(H2O)] and Zn[(PySmdt)(CH3COO)]1.5H2O w
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Book chapters on the topic "S-methyl derivatives"

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Taber, Douglass F. "The Baran Synthesis of Ingenol." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0089.

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The early promise for the biological activity of the derivatives of ingenol 3 has been borne out by the clinical efficacy of the derived angelate, recently approved by the US Food and Drug Administration for the treatment of actinic keratosis. Phil S. Baran of Scripps La Jolla envisioned (Science 2013, 341, 878) a route to 3 based on a rearrange­ment of 2, available by the Pauson–Khand cyclization of the allenyl alkyne 1. One of the partners for the preparation of 1 was available following the Sugai (Synlett 1997, 1297) procedure, by the Claisen rearrangement of triethyl orthopro­pionate 5 wit
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Weng, Ng Seik, Chen Wei, V. G. Kumar Das, Yap Chee Keong,, and Ray J. Butcher. "Crystal structure of tri-n-butyltin(IV) N-methyl-N-phenyldithiocarbamylacetate, (n-C4H9)3SnOC(O)CH2SC(S)N(CH3) (C6Hs)." In Chemistry and Technology of Silicon and Tin. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198555803.003.0052.

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Abstract Triorganotin carboxylate esters display several structural variations: triphenyltin thiophene-2-carboxylate is a monomeric molecule, triphenyltin pyridine- 3-carboxylate a flat, pyridyl-bridged polymer and triphenyltin 8-quinolyloxyacetate a water-coordinated, hydrogen-bonded helical chain; the carboxyl oxygen is not involved in either intra- or intermolecular coordination to tin in the three compounds. On the other hand, triphenyltin chloroacetate and triphenyltin 3-benzoylpropionate are carboxylate-bridged, a feature common to triorganotin esters whose carboxylate group is an acetat
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Taber, Douglass F. "C-H Functionalization: The Chen Synthesis of Celogentin C." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0019.

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Christian R. Goldsmith of Auburn University developed (Synlett 2010, 1377) a method for radical chlorination of 1 using commercial peracetic acid. Noritaka Mizuno of the University of Tokyo devised (Nat. Chem. 2010, 2, 478) a bulky polyoxometalate that mediated the selective hydroxylation of the secondary C-H bonds of 3. Christina White of the University of Illinois showed (Science 2010, 327, 566) that Fe-mediated C-H oxidation is sensitive to the expected electronic effects, so that 5 was selectively oxidized to 6. Irena S. Akhrem of the A. N. Nesmeyanov Institute of Organoelement Compounds e
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Akisheva, Alina, and Iryna Valivodz. "DOCKING ANALYSIS OF THE INTERACTION OF PROPOXAZEPAM WITH BIOTARGETS THAT REGULATE ITS MECHANISM OF ACTION AND PHARMACOLOGICAL ACTIVITY." In Science, technology and innovation in the modern world. Publishing House “Baltija Publishing”, 2023. http://dx.doi.org/10.30525/978-9934-26-364-4-7.

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One of 1.4-benzodiazepine 3-alcoxy derivatives – propoxazepam, possessing high analgetic action, also effectively suppresses experimental seizures of different etiology. Unexpected combination of pharmacological spectrum components suggests its different binding sites of GABAA receptor subunits.The aim of the work was docking analysis of the interaction of Propoxazepam with biotargets that mediate its mechanism of action and pharmacological activity (using experimental data of the propoxazepam conformation and calculated data for the three-dimensional structure of the ligand-binding site and s
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Taber, Douglass F. "The Baran Synthesis of Vinigrol." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0091.

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The diterpene vinigrol 3, isolated from Virgaria nigra F-5408, has eluded total synthesis for more than 20 years. Attempts to construct the four-carbon bridge on a preformed cis-decalin have been unavailing. Phil S. Baran of Scripps/La Jolla solved (Angewandte Chem. Int. Ed. 2008, 47, 3054; J. Am. Chem. Soc. 2009, 131, 17066) this problem by adding the extra C-C bond of 1, which could then be cleaved in course of a Grob fragmentation, leading to 2. The preparation of 1 started with the dihydroresorcinol derivative 4. Diels-Alder addition of the ester 5 gave 6, with a modest 2:1 dr. Addition of
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Conference papers on the topic "S-methyl derivatives"

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Karpenko, Yuriy. "Absorption of Free Radicals of New S-Derivatives (1,2,4-Triazole-3(2H)-yl)methyl)thiopyrimidines." In ECSOC 2024. MDPI, 2024. https://doi.org/10.3390/ecsoc-28-20181.

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Jabri, Atef, Jose Cernicharo, Belén Tercero, et al. "MILLIMETER WAVE SPECTRUM OF THE TWO MONOSULFUR DERIVATIVES OF METHYL FORMATE: S- AND O-METHYL THIOFORMATE, IN THE GROUND AND THE FIRST EXCITED TORSIONAL STATES." In 72nd International Symposium on Molecular Spectroscopy. University of Illinois at Urbana-Champaign, 2017. http://dx.doi.org/10.15278/isms.2017.wf07.

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Karpenko, Yu V. "Study of acute toxicity on Danio rerio hydrobionts of new s-derivatives (1,2,4-triazol-3(2H)-il)methyl)thiopyrimidines." In DEVELOPMENT OF THE HEALTHCARE SECTOR IN UKRAINE: THE PATH TOWARDS THE EUROPEAN UNION. Baltija Publishing, 2023. http://dx.doi.org/10.30525/978-9934-26-387-3-15.

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Podturkina, Alexandra, Oleg Ardashov, Alla Pavlova, and Tatyana Tolstikova. "(1<em>R</em>, 2<em>R</em>, 6<em>S</em>)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol derivatives as promising compounds for anti-Parkinsonian activity." In 6th International Electronic Conference on Medicinal Chemistry. MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07462.

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Potapova, I. A., E. V. Nielina, and N. V. Prokhorova. "Metal storage capacity evaluation of humic and himatomelanic acids hydroxymethyl derivatives obtained from brown coal." In VIII Vserossijskaja konferencija s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka». Publishing center of Ulyanovsk State University, 2021. http://dx.doi.org/10.34014/mpphe.2021-165-168.

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Humic substances represent the most extensive and reactive class of natural compounds. A more nature-saving way is to obtain humus substances from solid combustible minerals and waste from their processing. The ability of these compounds to form stable complexes with heavy metals, which increases with their directed chemical modification, has been experimentally confirmed. The effectiveness of the phenol-formaldehyde condensation method for the modification of initial humus substances has been confirmed. The interaction of humic and himatomelanic acids with formaldehyde leads to an increase in
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Christie, D. J., H. Diaz-Arauzo, and J. M. Cook. "REACTIONS OF DRUG-DEPENDENT ANTIBODIES WITH METABOLITES OF QUININE (Qn) AND QUINIDINE (Qd)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644578.

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In many cases of drug-induced immunologic thrombocytopenia (DITP), a metabolite, rather than the native drug, is suspected of provoking the destructive drug-dependent antibodies (DDAB) responsible for this severe hemorrhagic disorder. However, this has not previously been investigated for Qn- and Qd-DDAB. We report evidence that the native drugs, and not their metabolites, are the provocative agents in Qn and Qd DITP. Reactions of Qn- and Qd-DDAB with platelets were studied with the native drugs and four of their metabolites: the N-oxide and 10,11-diol derivatives (quinuclidine ring modificati
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Verbrugghe, Adronie, and Alexandra Rankovic. "Dietary choline in feline nutrition and its role in obesity prevention and liver health." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/gyun6061.

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In North America, 60% of cats is estimated to be overweight or obese, predisposing cats to obesity-related health consequences, which reduce quality and quantity of life. Weight loss is recommended, yet current protocols are often unsuccessful. Moreover, drastic energy restriction can put overweight and obese cats at risk of developing feline hepatic lipidosis which can be fatal if left untreated.Choline, an essential nutrient, can be found naturally in organ meats, eggs, soybean and wheat germ. Commercial pet foods contain a supplemental source of choline to meet the recommendations set by t
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