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1

Nelson, Eric A., and Donald Penner. "Reduction Of Isoxaflutole Injury To Corn (Zea Mays) with Herbicide Safeners And Water-repellent Adjuvants." Weed Technology 20, no. 4 (2006): 999–1003. http://dx.doi.org/10.1614/wt-05-100.1.

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The objectives of this research were to evaluate herbicide safeners and water repellents for their efficacy in reducing injury caused by isoxaflutole to corn at four application timings (PRE, spike, two-leaf, and four-leaf), and to evaluate the retention of the combinations of isoxaflutole, herbicide safeners, and water-repellent adjuvants. The safeners R-29148 and furilazole decreased injury from isoxaflutole when applied PRE. Corn injury increased from POST applications at the two-leaf and four-leaf stage of isoxaflutole mixed with safeners compared with isoxaflutole alone. The safeners may
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2

Hatzios, Kriton K. "An Overview of the Mechanisms of Action of Herbicide Safeners." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 819–27. http://dx.doi.org/10.1515/znc-1991-9-1017.

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Abstract Herbicide safeners are chemicals used for manipulating the tolerance of large-seeded grass crops to selected soil-applied herbicides. The physiological interactions of herbicides and their respective safeners are characterized by the following facts: a) safeners are most effective when applied prior to or simultaneously with the herbicides whose injury they prevent; b) safeners exhibit a high degree of botanical and chemical specificity protecting only certain grasses against injury caused from specific classes of herbicides; and c) protected grass crops are moderately tolerant to the
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3

Dutka, Ferenc. "Bioactive Chemical Bond Systems in Safeners and Prosafeners." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 805–9. http://dx.doi.org/10.1515/znc-1991-9-1014.

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Abstract Acetals and ketals involving a dichloromethyl group on their central carbon atom were found to be active or highly active as safeners of corn against thiocarbamate and chloroacet-anilide herbicide injury. A mechanism for the biotransformation of these compounds as pro­safeners to the actual dichloroacetic ester safeners is proposed. Similarly, S-and N-analogues of the cyclic acetals (ketals) which show safener activity can also be considered as prosafeners because they can be converted in the biophase by the same mechanism into actual safeners such as dichloroacetic thiolesters or dic
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4

Ekler, Zsigmond, and Ferenc Dutka. "Chemical Reactivity and Safener Activity of Acetal Compounds." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 810–14. http://dx.doi.org/10.1515/znc-1991-9-1015.

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Abstract Although detailed examinations have been published on structure-activity relationships of herbicide safeners, only a few data are available on chemical reactivity-safener activity relationships. Chemical reactivity of acetamide type compounds as well as their safener activity against thiocarbamate herbicides change with the number of chlorine substituents in the order: non-chlorinated < monochloro < dichloro. Several compounds of another chemical group, acetals (e.g. MG-191, 2-dichloromethyl-2-methyl-1,3-dioxolane), are also effective safeners for thiocarbamate herbicides. Accor
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5

Stephenson, Gerald R., and Tuvia Yaacoby. "Milestones in the Development of Herbicide Safeners." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 794–97. http://dx.doi.org/10.1515/znc-1991-9-1012.

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Abstract The concept of using chemical safeners to improve herbicide selectivity became widely known in 1969 with the introduction of naphthalic anhydride (NA) to improve the tolerance of maize to thiocarbamate herbicides. Soon thereafter dichlormid was also developed as a safener for thiocarbamates in maize. At present there are at least eight different chemical safeners that have been developed commercially. Many of these safeners have been most effec­tive for chloroacetamide or thiocarbamate herbicides in monocotyledonous crops such as maize or sorghum. Some are like dichlormid and have bee
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6

Elmore, Matthew T., James T. Brosnan, Gregory R. Armel, Jose J. Vargas, and Gregory K. Breeden. "Herbicide Safeners Increase Creeping Bentgrass (Agrostis stolonifera) Tolerance to Pinoxaden and Affect Weed Control." Weed Technology 30, no. 4 (2016): 919–28. http://dx.doi.org/10.1614/wt-d-16-00033.1.

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The herbicide pinoxaden is a phenylpyrazoline inhibitor of acetyl coenzyme A carboxylase. Research was conducted to determine the effects of pinoxaden (90 g ai ha−1) alone and in combination with herbicide safeners on creeping bentgrass injury as well as perennial ryegrass and roughstalk bluegrass control. Greenhouse experiments determined that herbicide safeners cloquintocet-mexyl, fenchlorazole-ethyl, and mefenpyr-diethyl were more effective in reducing creeping bentgrass injury from pinoxaden than benoxacor, isoxadifen-ethyl, and naphthalic-anhydride. Other experiments determined that creep
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7

Kunkel, Daniel L., John C. Steffens, and Robin R. Bellinder. "Effect of Temperature and Safeners on Glutathione Levels and Glutathione S-Transferase Activity in Maize." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 856–60. http://dx.doi.org/10.1515/znc-1991-9-1022.

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Abstract Studies were conducted to determine the biochemical aspects of chloroacetamide injury to maize and the mechanism by which safeners maintain herbicide tolerance, even at reduced temperatures. The objectives of these studies were threefold: one, determine whether gluta­thione (GSH) content varies in maize plants grown at three different temperatures in safener-treated and non-treated plants; two, determine whether glutathione S-transferase (GST) activ­ity varies in plants grown at different temperatures; and three, determine if GSH activity is sensitive to low temperatures in vitro. The
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8

Nelson, Eric A., and Donald Penner. "Leaching of Isoxaflutole and the Herbicide Safeners R-29148 and Furilazole." Weed Technology 21, no. 1 (2007): 106–9. http://dx.doi.org/10.1614/wt-06-036.1.

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The objectives of this study were to evaluate the leaching of isoxaflutole and the safeners R-29148 and furilazole to test the hypothesis that safeners and isoxaflutole were moving at different rates through the soil profile. The isoxaflutole movement down soil columns was measured by evaluating the visible injury on crop and weed bioassay species seeded into columns split longitudinally. The movement of the safeners was measured by evaluating the isoxaflutole injury to the crop assay species compared to the injury observed without a safener present. The results indicated that a heavy rainfall
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9

Iqtiar, Md Siddique. "Herbicides and Safeners: Enhancing Agricultural Productivity and Environmental Safety." European Journal of Advances in Engineering and Technology 10, no. 11 (2023): 40–46. https://doi.org/10.5281/zenodo.12804511.

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Herbicides and safeners play a crucial role in modern agriculture by enhancing crop productivity and ensuring environmental safety. Herbicides are chemical substances used to control or eliminate unwanted vegetation, particularly weeds, which compete with crops for nutrients, water, and sunlight. However, the application of herbicides can also pose risks to crops and the environment, necessitating the use of safeners. Safeners are compounds added to herbicide formulations to protect crops from potential damage caused by herbicides, without compromising their effectiveness against weeds. This e
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10

Ekler, Zsigmond, and Gerald R. Stephenson. "Comparative Effectiveness and Mode of Action of Safeners for Chloroacetamide Herbicides in Maize Seedlings." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 828–35. http://dx.doi.org/10.1515/znc-1991-9-1018.

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Abstract In growth room bioassays, four herbicide safeners {BAS-145138: 1-dichloroacetyl-hexa-hydro-3,3,8a-trimethyl-pyrrolo(1,2a)pyrimidin-6(2H)-one, dichlormid: N,N-diallyl-2,2-dichloroacetamide, flurazole: phenylmethyl 2-chloro-4-(trifluoromethyl)-5-thiazole-carboxylate and MG-191: 2-dichloromethyl-2-methyl-1,3-dioxolane} were compared for their effective­ ness in reducing metazachlor {N-(2,6-dimethylphenyl)-N-(1-pyrazolylmethyl)-chloroacet-amide} injury to maize seedlings. Three of these compounds (BAS-145138, dichlormid and MG-191) and two different compounds (AD-67: N-dichloroacetyl-1-ox
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11

Simarmata, Marulak, and Donald Penner. "Protection from Primisulfuron Injury to Corn (Zea mays) and Sorghum (Sorghum bicolor) with Herbicide Safeners." Weed Technology 7, no. 1 (1993): 174–79. http://dx.doi.org/10.1017/s0890037x00037088.

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Greenhouse studies were conducted to evaluate and compare herbicide safeners for protection of corn and sorghum from herbicidal injury from metolachlor, primisulfuron, and the interaction of primisulfuron with terbufos, an insecticide. With the exception of CGA-133205 which killed corn, the safeners oxabetrinil, flurazole, naphthalic anhydride, dichlormid, and R-29148 protected against significant injury from the interaction between primisulfuron (40 g ai ha−1) and terbufos (9.8 kg ha−1equivalent to 750 g per 1000 m of row) and from metolachlor (6.7 kg ai ha−1). No primisulfuron-terbufos inter
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12

Griffin, Timothy S., Lowell E. Moser, and Alex R. Martin. "Influence of Antidotes on Forage Grass Seedling Response to Metolachlor and Butylate." Weed Science 36, no. 2 (1988): 202–6. http://dx.doi.org/10.1017/s0043174500074713.

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Field studies were conducted for 3 yr near Mead, NE, to evaluate the effectiveness of seed safeners CGA-92194 [N-(1,3-dioxalon-2-yl-methoxy)iminobenzeneacetonitrile], NA (1,8-naphthalic anhydride), and R-29148 (2,2-dimethyl-5-methyldichloroacetyloxazolidine) to reduce herbicide injury to big bluestem (Andropogon gerardiiVitman), indiangrass[Sorghastrum nutans(L.) Nash], intermediate wheatgrass[Agropyron intermedium(Host.) Beauv.], sideoats grama[Bouteloua curtipendula(Michx.) Torr.], and switchgrass (Panicum virgatumL.) from preplant-incorporated butylate [5-ethyl bis-(2-methylpropyl)carbamoth
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13

Gao, Liu, Jiang, et al. "Protective Responses Induced by Chiral 3-Dichloroacetyl Oxazolidine Safeners in Maize (Zea mays L.) and the Detoxification Mechanism." Molecules 24, no. 17 (2019): 3060. http://dx.doi.org/10.3390/molecules24173060.

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Herbicide safeners selectively protect crops from herbicide injury while maintaining the herbicidal effect on the target weed. To some extent, the detoxification of herbicides is related to the effect of herbicide safeners on the level and activity of herbicide target enzymes. In this work, the expression of the detoxifying enzyme glutathione S-transferase (GST) and antioxidant enzyme activities in maize seedlings were studied in the presence of three potential herbicide safeners: 3-dichloroacetyl oxazolidine and its two optical isomers. Further, the protective effect of chiral herbicide safen
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14

Gerhards, Roland, and Hans-Joachim Santel. "Kann die Saatgutbehandlung mit dem Safener Cyprosulfamid die Verträglichkeit von Isoxaflutole in Mais steigern, die Unkrautbekämpfung verbessern und die Wirkstoffmenge verringern?" Gesunde Pflanzen 72, no. 4 (2020): 371–81. http://dx.doi.org/10.1007/s10343-020-00519-1.

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Zusammenfassung Herbizide Wirkstoffe werden in kommerziellen Produkten manchmal mit Safenern kombiniert, um die Verträglichkeit des Herbizids für die Kulturpflanze zu gewährleisten. Dabei regen Safener meist die Metabolisierung von Herbiziden in der Kulturpflanze an. Das Herbizid Isoxaflutole (IFT) wird in Mais mit dem Safener Cyprosulfamid (CSA) als Co-Formulierung angewendet. In dieser Arbeit wurde untersucht, ob CSA auch zeitlich getrennt von IFT als Saatgutbehandlung den Mais vor Herbizidschäden durch IFT schützen kann und ob die Unkrautbekämpfung in diesem Fall höher ist als bei der Co-Fo
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15

Böger, Peter, and Roswitha Miller. "Protoporphyrin Accumulation Induced by Peroxidizing Herbicides is Counteracted by Safeners." Zeitschrift für Naturforschung C 49, no. 11-12 (1994): 775–80. http://dx.doi.org/10.1515/znc-1994-11-1213.

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A number of safeners like naphthalene-1,8-dicarboxylic acid anhydride (naphthalic anhydride) or dichloroacetyl-hexahydro-3,3,8-α-trimethylpyrrolo-[1 ,2 α]-pyrimidine-6-(2H̲)-one (BAS 145138) drastically decreased the accumulation of protoporphyrin IX induced by a peroxidative cyclic imide (chlorophthalim, N-(4-chlorophenyl)-3,4,5,6-tetrahydrophthalimide), or p-nitrodiphenyl ether (acifluorfen methyl, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoicmethylester). This effect was observed with etiolated maize and cress seedlings during a 16-h illumination period with these herbicides and 0.
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16

Bernards, Mark L., Joseph T. Simmons, Corey J. Guza, Crystal R. Schulz, Donald Penner, and James J. Kells. "Inbred Corn Response to Acetamide Herbicides as Affected by Safeners and Microencapsulation." Weed Technology 20, no. 2 (2006): 458–65. http://dx.doi.org/10.1614/wt-05-130r.1.

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Corn inbreds are often more sensitive to herbicides than hybrids. Field experiments were conducted with three corn inbreds to (1) evaluate inbred sensitivity to the acetamide herbicides acetochlor, dimethenamid, flufenacet, and metolachlor, (2) compare the effects of various crop safeners in combination with acetochlor and metolachlor, and (3) measure the effect of herbicide microencapsulation on acetochlor injury. Herbicides were applied preemergence at the registered rate and at two, three, or four times the registered rate in corn. Injury ratings, plant population, and the percentage of pla
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17

Giraldo-Acosta, Manuela, and Marino B. Arnao. "Melatonin, A Promising Natural Crop Safener." Outlooks on Pest Management 35, no. 3 (2024): 115–19. http://dx.doi.org/10.1564/v35_jun_06.

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The simultaneous use of pesticides and safeners was established as a tool to protect crops. Several lab trials suggest that the use of melatonin as a natural safener can be an interesting, inexpensive, and eco-friendly strategy to improve crops and pest management.
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18

Matolcsy, György, Ágota Tombor, and Antal Gimesi. "Dithiocarbamate Derivatives as Herbicide Safeners." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 815–18. http://dx.doi.org/10.1515/znc-1991-9-1016.

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Abstract The growing environmental and toxicological concern about the dichloroacetamide type herbicide safeners prompted us to search for alternative safener types. Based on analogy con­siderations, a random screening of structurally unrelated bivalent sulphur compounds was performed, followed by successive structure optimization phases representing both speculative and empirical elements. Dithiocarbamate ester type compounds derived from 1,4-exaza-spiro[4.5]decane revealed highest protecting potency both agains thiolcarbamate and chlor-acetanilide herbicides in corn (Zea mays L.), with the b
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19

Deng, Xile. "Current Advances in the Action Mechanisms of Safeners." Agronomy 12, no. 11 (2022): 2824. http://dx.doi.org/10.3390/agronomy12112824.

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Herbicide safeners are a series of agrochemicals that can selectively protect crop plants from herbicide injury without affecting herbicidal efficacy. Understanding mechanisms by which safeners act is significant for discovery of novel types. Safeners primarily alleviate herbicide phytotoxicity to crop plants via several actions: (i) enhancing metabolism of herbicides in crops; (ii) affecting absorption and transportation of herbicides in crops; (iii) competitively binding to herbicide target sites; and (iv) affecting activity of target enzymes. This review describes recent advances in the act
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20

Deng, Xile. "A Mini Review on Natural Safeners: Chemistry, Uses, Modes of Action, and Limitations." Plants 11, no. 24 (2022): 3509. http://dx.doi.org/10.3390/plants11243509.

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Herbicide injury is a common problem during the application of herbicides in practice. However, applying herbicide safeners can avoid herbicide damage. Safeners selectively protect crops against herbicide injury without affecting the biological activity of herbicides against the target weeds. However, after long-term application, commercial safeners were found to pose risks to the agricultural ecological environment. Natural safeners are endogenous compounds from animals, plants, and microbes, with unique structures and are relatively environment-friendly, and thus can address the potential ri
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21

Liu, Li-Ming, Qi-Fan Pang, and Yue Zhai. "Crystal structure and biological activity studies of two different types of herbicide safeners." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 03 (2024): 281. http://dx.doi.org/10.59467/ijhc.2024.34.281.

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Two heterocyclic compounds, imidazolidine-1,3-diylbis((5-methyl-3-phenylisoxazol-4-yl)methanone) (I) and (5-methylisoxazol-3-yl)(1-oxa-4-azaspiro[4.5]decan-4-yl)methanone (II), were characterized by X-rays. Compound I was crystallized in monoclinic system, space group Cc, a= 9.81000(12) Å, b= 15.21199(16) Å, c= 14.25369(17) Å, β= 90.3862 (12)degree, Z= 4, V= 2127.02(4) Å3, F(000) = 928.0, Dc= 1.382 Mg/m3, crystal size: 0.150 x 0.130 x 0.120 mm. Compound II was crystallized in the monoclinic system, space group P21/n, a = 5.6113(5) Å, b = 11.2280(10) Å, c = 20.675(2) Å, β = 95.543(10)degree, Z
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22

Castro, Edicarlos, Carolina Pucci, Stefano Duarte, Nilda Roma Burgos, and Te Ming Tseng. "Improved herbicide selectivity in tomato by safening action of benoxacor and fenclorim." Weed Technology 34, no. 5 (2020): 647–51. http://dx.doi.org/10.1017/wet.2020.30.

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AbstractSafeners have been widely used to reduce phytotoxicity to crops, thus serving as an alternative weed control strategy. Benoxacor and fenclorim safeners have the potential to protect plants from herbicide phytotoxicity by increasing glutathione S-transferase (GST) activity within the plant. The study aimed to evaluate the safening effect of benoxacor and fenclorim on tomato against selected herbicides applied POST. The experiment was conducted in a greenhouse in a completely randomized designed with four replications in a 9 × 3 factorial scheme, where Factor A consisted of eight herbici
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23

Fu, Ying, Hai Tao Li, Qing Shan Zhao, and Fei Ye. "CoMSIA Study of a Series of N-Dichloroacetyl Oxazolidine Derivatives." Applied Mechanics and Materials 195-196 (August 2012): 380–84. http://dx.doi.org/10.4028/www.scientific.net/amm.195-196.380.

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Comparative molecular similarity indices analysis (CoMSIA) were performed on N-dichloroacetyl oxazolidine derivatives as herbicide safeners. The best CoMSIA models that were generated using atom based alignmen, Rcv2=0.632, n=4, R2=0.927, F=31.796 and s=0.097. The contributions of steric field, electrostatics field, hydrophobicities field and hydrogenbond acceptor were 0.127, 0.260, 0.285 and 0.328, respectively. The CoMSIA model was satisfactory and would be useful for the future design of new N-dichloroacetyl oxazolidine herbicide safener.
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24

Deng, Xile, Wenna Zheng, Qingcai Zhan, Yanan Deng, Yong Zhou, and Lianyang Bai. "New Lead Discovery of Herbicide Safener for Metolachlor Based on a Scaffold-Hopping Strategy." Molecules 25, no. 21 (2020): 4986. http://dx.doi.org/10.3390/molecules25214986.

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The use of herbicide safeners can significantly alleviate herbicide injury to protect crop plants and expand the application scope of the existing herbicides in the field. Sanshools, which are well known as spices, are N-alkyl substituted compounds extracted from the Zanthoxylum species and have several essential physiological and pharmacological functions. Sanshools display excellent safener activity for the herbicide metolachlor in rice seedlings. However, the high cost of sanshools extraction and difficulties in the synthesis of their complicated chemical structures limit their utilization
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25

Kőmíves, Tamás, and Kriton K. Hatzios. "Chemistry and Structure-Activity Relationships of Herbicide Safeners." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 798–804. http://dx.doi.org/10.1515/znc-1991-9-1013.

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Abstract The discovery and commercial success of safeners against thiolcarbamate herbicide injury to corn has stimulated a rapid progress and opened new possibilities for further research and development in the last decade. Compounds with new chemistry, increased efficacy, and a broader selectivity spectrum were synthesized and developed for agricultural use. Structure-activity relationship studies helped to optimize their chemical properties and to understand their biological modes of action. Several examples indicate close similarity between chemical structures possessing herbicidal and safe
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26

Edwards, Robert, Daniele Del Buono, Michael Fordham, et al. "Differential Induction of Glutathione Transferases and Glucosyltransferases in Wheat, Maize and Arabidopsis thaliana by Herbicide Safeners." Zeitschrift für Naturforschung C 60, no. 3-4 (2005): 307–16. http://dx.doi.org/10.1515/znc-2005-3-416.

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Abstract By learning lessons from weed science we have adopted three approaches to make plants more effective in phytoremediation: 1. The application of functional genomics to identify key components involved in the detoxification of, or tolerance to, xenobiotics for use in subsequent genetic engineering/breeding programmes. 2. The rational metabolic engineering of plants through the use of forced evolution of protective enzymes, or alternatively transgenesis of detoxification pathways. 3. The use of chemical treatments which protect plants from herbicide injury. In this paper we examine the r
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27

Moreland, Donald E., and Frederick T. Corbin. "Influence of Safeners on the in vivo and in vitro Metabolism of Bentazon and Metolachlor by Grain Sorghum Shoots: a Preliminary Report." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 906–14. http://dx.doi.org/10.1515/znc-1991-9-1031.

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Abstract Metabolism of bentazon and metolachlor by excised shoots and a microsomal fraction iso­lated from the shoots, of 3-day-old, dark-grown, grain sorghum (Sorghum bicolor cv. Funk G 522 DR) seedlings was studied. The effects of seed treatments, on the subsequent metabo­lism of the herbicides, with the safeners naphthalic anhydride, oxabetrinil, and CGA 133205 were compared against surface-sterilization and Captan-treatments. Bentazon was aryl hydroxylated in both in vivo and in vitro studies with the hydroxylated derivative undergoing glycosylation only under in vivo conditions. Both shoo
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28

Zhang, Zujie, G. Euel Coats, and Albert H. Boyd. "Germination and Seedling Growth of Sorghum (Sorghum bicolor) Hybrids After Seed Storage with Safeners at Varying Humidities." Weed Science 42, no. 1 (1994): 98–102. http://dx.doi.org/10.1017/s004317450008423x.

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Laboratory and growth room experiments were conducted to determine effects of CGA-133205, oxabetrinil, and flurazole on grain sorghum hybrids ‘DeKalb 46’ and ‘DeKalb 48’ after the seed were treated with the herbicide safeners and stored for up to 24 wk at various relative humidity levels. Each safener treatment had an adverse effect on grain sorghum seed as reflected by fewer normal seedlings at 4 d when averaged over storage time and relative humidity levels. Flurazole and oxabetrinil increased the number of ungerminated seed of both hybrids, and 0.4 and 0.8 g ai kg–1CGA-133205 increased unge
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29

de Oliveira, Tabata Raissa, Antonio Augusto Correa Tavares, Shaun Broderick, Taghi Bararpour, and Te Ming Tseng. "Assessing the Protective Effects of Benoxacor, Fenclorim, Melatonin, and 2,4,6-Trichlorophenoxyacetic Acid Against Herbicide Injury in Tomato." HortTechnology 34, no. 6 (2024): 782–88. http://dx.doi.org/10.21273/horttech05480-24.

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Safeners protect crops by enhancing their ability to metabolize various compounds, including herbicides. They increase a crop’s tolerance to herbicide damage, activating herbicide-metabolizing proteins, and aiding in their detoxification. This study aimed to investigate the chemical effects of safeners in tomato cultivation and focus on injury reduction and tissue protection. The experiment followed a randomized factorial design (5 × 4) with four replications repeated twice. We evaluated the effects of herbicides dicamba, 2,4-D, metribuzin, and sulfentrazone (diluted to 1% of the recommended f
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30

Davies, Joanna, and John C. Caseley. "Herbicide safeners: a review." Pesticide Science 55, no. 11 (1999): 1043–58. http://dx.doi.org/10.1002/(sici)1096-9063(199911)55:11<1043::aid-ps60>3.0.co;2-l.

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31

Kunkel, Daniel L., Robin R. Bellinder, and John C. Steffens. "Safeners Reduce Corn (Zea mays) Chloroacetanilide and Dicamba Injury Under Different Soil Temperatures." Weed Technology 10, no. 1 (1996): 115–20. http://dx.doi.org/10.1017/s0890037x00045802.

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The results of two experiments involving the effects of safeners on chloroacetanilide and dicamba injury in corn are reported here. The first experiment was conducted to determine whether MON-4660, CGA-154281, dichlormid, and MON-13900 would increase corn tolerance to alachlor, metolachlor, and acetochlor, respectively, over a range of soil temperatures (12 to 37 C). All three herbicides, particularly acetochlor, reduced corn shoot lengths at temperatures less than 32 C. The safeners effectively increased corn tolerance to their respective chloroacetanilide herbicide at all soil temperatures.
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32

Zhao, Li-Xia, Hai-Tao Qu, Ying Fu, Shuang Gao, and Fei Ye. "Alleviation of injury from chlorimuron-ethyl in maize treated with safener 3-dichloroacetyl oxazolidine." Canadian Journal of Plant Science 95, no. 5 (2015): 897–903. http://dx.doi.org/10.4141/cjps-2014-437.

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Zhao, L.-X., Qu, H.-T., Fu, Y., Gao, S. and Ye, F. 2015. Alleviation of injury from chlorimuron-ethyl in maize treated with safener 3-dichloroacetyl oxazolidine. Can. J. Plant Sci. 95: 897–903. The protective effects of herbicide safeners, including 3-dichloroacetyl-2,2-dimethyl-1,3-oxazolidine (R-28725), 3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine (Racemate), and its two enantiomers (R)-3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine (R-enantiomer) and (S)-3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine (S-enantiomer), on reducing the phytotoxicity of chlorimuron-ethyl t
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Cottingham, C. K., and K. K. Hatzios. "Influence of the Safener Benoxacor on the Metabolism of Metolachlor in Corn." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 846–49. http://dx.doi.org/10.1515/znc-1991-9-1020.

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Abstract The herbicide safener benoxacor (CGA -154281) is effective in protecting corn from meto­lachlor injury. Glutathione-S-transferase (GST) activity of corn seedlings was stimulated by low concentrations of benoxacor as was the formation of a polar metabolite identified as the glutathione (GSH) conjugate of metolachlor. A similar degree of enhancement of metolachlor metabolism was observed in both a metolachlor-tolerant (’Cargill 7567’) and a metolachlor-susceptible (’Northrup-King 9283’) corn line. The total GSH content of shoots of the metolachlor-susceptible corn hybrid was not affecte
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Farago, Slobodan, Christian Brunold, and Klaus Kreuz. "Herbicide safeners and glutathione metabolism." Physiologia Plantarum 91, no. 3 (1994): 537–42. http://dx.doi.org/10.1111/j.1399-3054.1994.tb02985.x.

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Farago, Slobodan, Christian Brunold, and Klaus Kreuz. "Herbicide safeners and glutathione metabolism." Physiologia Plantarum 91, no. 3 (1994): 537–42. http://dx.doi.org/10.1034/j.1399-3054.1994.910326.x.

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36

Kral, Andrew E., Nicholas C. Pflug, Monica E. McFadden, Gregory H. LeFevre, John D. Sivey, and David M. Cwiertny. "Photochemical Transformations of Dichloroacetamide Safeners." Environmental Science & Technology 53, no. 12 (2019): 6738–46. http://dx.doi.org/10.1021/acs.est.9b00861.

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37

Kotoula-Syka, Eleni, and Kriton K. Hatzios. "Interactions of Tribenuron with Four Safeners and Piperonyl Butoxide on Corn (Zea mays)." Weed Science 44, no. 2 (1996): 215–18. http://dx.doi.org/10.1017/s0043174500093802.

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The efficacy of the safeners naphthalic anhydride (NA), R-29148, benoxacor, and dichlormid as protectants of corn against injury from the methyl ester of tribenuron was evaluated under greenhouse conditions. Tribenuron applied alone reduced the root length of both ‘Pioneer 3180’ and ‘Northrup-King 9283’ corn. The concentration of tribenuron causing 50% reduction of corn root length (GR50) was 1 μM. NA applied as a seed dressing at 0.5 and 1.0% (w/w) was the most effective of the four safeners tested and provided excellent protection to both corn hybrids against 1, 2, and 4 μM tribenuron. Soaki
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Matzenbacher, Felipe de Oliveira, Guilherme Ávila Soares, Roberto Fachinello, et al. "Safeners: impacto dos fatores ambientais, genéticos e interações entre agrotóxicos na fisiologia de sementes tratadas." CONTRIBUCIONES A LAS CIENCIAS SOCIALES 17, no. 1 (2024): 4821–39. http://dx.doi.org/10.55905/revconv.17n.1-289.

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O sucesso no controle de plantas daninhas evoluiu com o desenvolvimento de safeners ou protetores. O tratamento de sementes com esses produtos químicos facilitou o manejo de herbicidas e reduziu a interferência no estabelecimento da lavoura. Porém, em algumas situações, esse tratamento de sementes proporciona interferências negativas nos atributos fisiológicos de sementes. Dessa forma, os objetivos desta revisão são identificar e descrever fatores que podem interferir na ação dos safeners em função de questões ambientais, com interação entre diferentes classes de defensivos vegetais ou fertili
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Simonsen, Derek, Nicole Cady, Chunyun Zhang, et al. "The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice." Toxicological Sciences 186, no. 1 (2021): 102–17. http://dx.doi.org/10.1093/toxsci/kfab142.

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Abstract The toxicity of many “inert” ingredients of pesticide formulations, such as safeners, is poorly characterized, despite evidence that humans may be exposed to these chemicals. Analysis of ToxCast data for dichloroacetamide safeners with the ToxPi tool identified benoxacor as the safener with the highest potential for toxicity, especially liver toxicity. Benoxacor was subsequently administered to mice via oral gavage for 3 days at concentrations of 0, 0.5, 5, and 50 mg/kg bodyweight (b.w.). Bodyweight-adjusted liver and testes weights were significantly increased in the 50 mg/kg b.w. gr
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Wilkinson, R. E., and R. R. Duncan. "Oxabetrinil Reversal of Metolachlor and Acid Soil Stress." Zeitschrift für Naturforschung C 46, no. 11-12 (1991): 950–56. http://dx.doi.org/10.1515/znc-1991-11-1204.

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Metolachlor and excess Mn2+ (acid soil stress) induce alterations in gibberellin precursor biosynthesis that can explain the morphological responses to these physiological stresses. Oxabetrinil protects sorghum [Sorghum bicolor (L.) Moench] from the influence of metolachlor and excess Mn2+. Sorghum cultivar variations in response to excess Mn2+ are explicable as differential rates of ent-kaurene biosynthesis between acid soil sensitive and tolerant cultivars. Concentrations of Mn2+ present in vegetative leaves and reproductive stem tissues were not different. Therefore, cultivar differences in
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Wilkinson, R. E., and R. R. Duncan. "Oxabetrinil Reversal of Metolachlor and Acid Soil Stress." Zeitschrift für Naturforschung C 46, no. 9-10 (1991): 950–56. http://dx.doi.org/10.1515/znc-1991-9-1039.

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Abstract Metolachlor and excess Mn2+ (acid soil stress) induce alterations in gibberellin precursor biosynthesis that can explain the morphological responses to these physiological stresses. Oxa­betrinil protects sorghum [Sorghum bicolor (L.) Moench] from the influence of metolachlor and excess Mn2+. Sorghum cultivar variations in response to excess Mn2+ are explicable as dif­ferential rates of ent-kaurene biosynthesis between acid soil sensitive and tolerant cultivars. Concentrations of Mn2+ present in vegetative leaves and reproductive stem tissues were not different. Therefore, cultivar dif
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42

Elmore, Matthew T., James T. Brosnan, Gregory R. Armel, Jose J. Vargas, and Gregory K. Breeden. "Influence of Herbicide Safeners on Creeping Bentgrass (Agrostis stolonifera) Tolerance to Herbicides." Weed Technology 29, no. 3 (2015): 550–60. http://dx.doi.org/10.1614/wt-d-14-00045.1.

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Glasshouse research was conducted to investigate the efficacy of herbicide safeners for improving creeping bentgrass (CBG) tolerance to various herbicides. CBG injury from amicarbazone (150 g ha−1), bispyribac-sodium (110 g ha−1), fenoxaprop-p-ethyl (35 g ha−1), imazapic (45 g ha−1), quinclorac (1,050 g ha−1), or topramezone (37 g ha−1) applied in combination with the herbicide safeners naphthalic anhydride or isoxadifen-ethyl was evaluated. These safeners reduced CBG injury from topramezone only. Topramezone was then applied in combination with naphthalic anhydride, isoxadifen-ethyl, cloquint
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Hatzios, Kriton K., and Nilda Burgos. "Metabolism-based herbicide resistance: regulationby safeners." Weed Science 52, no. 3 (2004): 454–67. http://dx.doi.org/10.1614/p2002-168c.

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Ricko, Allison N., Andrew W. Psoras, and John D. Sivey. "Reductive transformations of dichloroacetamide safeners: effects of agrochemical co-formulants and iron oxide + manganese oxide binary-mineral systems." Environmental Science: Processes & Impacts 22, no. 10 (2020): 2104–16. http://dx.doi.org/10.1039/d0em00331j.

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45

Zhao, Yaning, Wenqing Li, Lanlan Sun, et al. "Candidate Genes Involved in Tolerance to Fenoxaprop-P-Ethyl in Rice Induced by Isoxadifen-Ethyl Hydrolysate." Agronomy 13, no. 1 (2023): 225. http://dx.doi.org/10.3390/agronomy13010225.

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The metabolic resistance of plants to herbicides is similar to the herbicide metabolism process accelerated by safeners. The tolerance to fenoxaprop-P-ethyl (FE) is distinct among different varieties of rice in which phytotoxicity forms easily, resulting in the restricted use of FE in paddy. Safener effectively resolves this issue. This study showed that rice 9311 and Meixiangzhan No. 2 (MXZ) had different tolerance mechanisms to FE. Isoxadifen-ethyl hydrolysate (IH) alleviated FE the inhibition of rice growth. Transcriptome sequencing revealed numerous differentially expressed genes (DEGs) be
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46

Braverman, Michael P., Terry L. Lavy, and Ronald E. Talbert. "Effects of Metolachlor Residues on Rice (Oryza sativa)." Weed Science 33, no. 6 (1985): 819–24. http://dx.doi.org/10.1017/s0043174500083429.

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Field studies were conducted on a Taloka silt loam (Mollic Albaqualf) to determine the effects of residual levels of metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide] on rice (Oryza sativaL.). Yield reductions could be overcome by increasing rice seeding rate, by decreasing seeding depth, or by applying the safeners CGA-43089 [α-(cyanomethoxyimino)-benzacetonitrile] or CGA-92194 [α-(1,3-dioxolan-2-yl-methoximino)-benzacetonitrile] to the rice seed. Greenhouse studies with the safeners and reduced seeding depths indicated that CGA-92194 was better than CGA-4
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Cottingham, Charles K., Kriton K. Hatzios, and Sue Meredith. "Influence of Chemical Treatments on Glutathione S-Transferases of Maize with Activity Towards Metolachlor and Cinnamic Acid." Zeitschrift für Naturforschung C 53, no. 11-12 (1998): 973–79. http://dx.doi.org/10.1515/znc-1998-11-1207.

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Abstract The subcellular distribution of glutathione S-transferase (GST) activity extracted from shoots of 3-day-old etiolated seedlings of maize (Zea mays L., Northrup-K ing 9283 hybrid) and the induction of soluble and m em brane-bound G ST activity by the safener benoxacor, the herbicide metolachlor and their com bination (CGA -180937) were investigated. GST activity extracted from maize shoots was detected in both cytosolic and microsomal fractions and utilized l-chloro-2,4-dinitrobenzene (CDNB ), metolachlor, and trans-cinnamic acid (CA) as substrates. Soluble GST activity extracted from
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Ye, Fei, Peng Ma, Yue Zhai, et al. "Design, microwave-assisted synthesis, bioactivity and SAR of novel substituted 2-phenyl-2-cyclohexanedione enol ester derivatives." RSC Advances 8, no. 35 (2018): 19883–93. http://dx.doi.org/10.1039/c8ra02647e.

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Based on the structure–activity relationship and active substructure combination, a novel class of substituted 2-phenyl-2-cyclohexanedione enol ester derivatives was designed for use as potential herbicide safeners.
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49

Kotoula-Syka, Eleni, Kriton K. Hatzios, and Sue A. Meredith. "Interactions Between SAN 582H and Selected Safeners on Grain Sorghum (Sorghum bicolor) and Corn (Zea mays)." Weed Technology 10, no. 2 (1996): 299–304. http://dx.doi.org/10.1017/s0890037x00039993.

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The efficacy of the safeners naphthalic anhydride (NA), CGA-92194, and CGA-133205 as protectants of grain sorghum and of NA, R-29148, CGA-154281, and dichlormid as protectants of corn against injury from the chloroacetamide herbicide, SAN 582H, was evaluated under greenhouse conditions. SAN 582H applied alone reduced the shoot growth of ‘Funk G522DR’ and ‘Funk G623’ sorghum, but had no effect on the growth of the ‘GP-10’ genotype of sorghum. Corn (‘Northrup-King 9283’ hybrid) was considerably more tolerant than grain sorghum to SAN 582H. The rate of SAN 582H causing 50% reduction of corn shoot
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Stoilkova, Gergana, and Petranka Yonova. "Safeners for chlorsulfuron on maize (Zea mays L.)." Quality Assurance and Safety of Crops & Foods 2, no. 1 (2010): 28–35. http://dx.doi.org/10.1111/j.1757-837x.2010.00047.x.

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