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Journal articles on the topic "% saturation of transferring"
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Hemangini, Chaudhari, Dixit R., and Jadeja J.M. "Serum Level Of Iron And Transferrin In Normal And Anemic Pregnant Women." International Journal of Basic and Applied Physiology 2, no. 1 (2013): 123–26. https://doi.org/10.5281/zenodo.4483106.
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Iron deficiency anemia is a major health problem in our country especially in pregnancy. For accurate diagnosis of iron deficiency anemia we require accurate indicators based on which treatment can be given. Purpose of this study is to prevent unnecessary iron overload by accurate diagnosis in pregnancy as excessive iron can lead to oxidative damage. Method: Serum level of Iron and transferrin and total iron binding capacity and % saturation of transferrin were estimated in 70 women in their I, II and III trimester of pregnancy. Only healthy subjects (without infective, metabolic, and degenerative disease) on clinical examination were selected. The women were divided into three groups according to their hemoglobin level in normal, mild anemic and moderate to severe anemia. Result: In normal group serum iron levels were within normal range in all trimester, whereas in anemic groups serum iron level were lower. Serum transferrin level was raised in III trimester in all the groups and also raised in I and II trimester in severe anemic group. TIBC was increased with decreased in serum iron level. % saturation of transferrin was lowered with lowered hemoglobin level. Conclusion: Our study shows iron level can be well correlated with haemoglobin level but transferrin level cannot be well correlated. But % of transferrin saturation can be a better indicator then transferrin.
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Naureen, Tallat, Umbreen Ahmed, Bushra Riaz, Ujala Ali, Javaria Sharafat, and Ehsan Shabbir. "ASSOCIATION BETWEEN IRON STATUS AND GESTATIONAL DIABETES MELLITUS." Pakistan Journal of Physiology 18, no. 2 (2022): 47–50. http://dx.doi.org/10.69656/pjp.v18i2.1453.
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Background: Early identification of risk factors for gestational diabetes may result in its prevention and better management. In this study, we aimed to compare serum iron, total iron binding capacity and transferring saturation in pregnant women with and without gestational diabetes. Methods: A comparative cross sectional analytical study was conducted at Army Medical College and Centre for Research in Experimental and Analytical Medicine (CREAM) in association with Pak Emirates Military Hospital. Thirty healthy pregnant women and thirty patients of gestational diabetes mellitus matched for age, gestational age and body mass index (BMI) were recruited for the study. The diagnosis of gestational diabetes was made on the basis of abnormal glucose tolerance test at twenty four weeks of gestation. Serum iron and total iron binding capacity of all subjects were measured using colorimetric assay and transferrin saturation was calculated. Analysis of data was carried using SPSS-22. Mean values were calculated for all variables and compared by two sample t-test. Pearson correlation was determined to find association between different quantitative variables in two groups and p?0.05 was considered significant. Results: Serum iron was significantly higher (p=0.007), TIBC significantly lower (p=0.004) and transferrin saturation significantly higher (p<0.001) in gestational diabetes group as compared to control group. Conclusion: Markers of iron status including serum iron and transferrin saturation were higher in patients of gestational diabetes and may pose a risk of developing gestational diabetes mellitus. Pak J Physiol 2022;18(2):47–50
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Kim, Yaewon, Chia-Hsiu Chen, and Christian Hilty. "Direct observation of Ru-alkylidene forming into ethylene in ring-closing metathesis from hyperpolarized 1H NMR." Chemical Communications 54, no. 34 (2018): 4333–36. http://dx.doi.org/10.1039/c7cc08135a.
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Saha, Ananya, Pradip Mukhopadhyay, Indrajit Nath, Arun Kumar, and Utpal Kumar Biswas. "A quantitative assessment of body iron status and its relationship with glycemic control in patients of type 2 diabetes mellitus in a tertiary care hospital of Kolkata." Asian Journal of Medical Sciences 12, no. 5 (2021): 69–74. http://dx.doi.org/10.3126/ajms.v12i5.33344.
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Background: Diabetes is one of the most common disease which is observed in every household of Indian population. The longevity of the diabetic patients is dependent upon the frequency of complication and comorbidity that they encounter. Serum iron and ferritin, both being the aggravators to the oxidative stress accelerating the development of complications, gives us the reason to venture into the territory exploring the possibility of monitoring the body iron stores and taking prevent measures to control such complication. The current study was designed with an aim to knot the relationship between body iron stores and glycemic control in patients of type-II diabetes mellitus.
 Aims and Objectives: To measure the levels of serum ferritin, serum Iron, transferrin saturation and HbA1C and finding out the relationship between body iron stores and glycemic control in patients of Type-II Diabetes Mellitus.
 Materials and Methods: A total of 50 diagnosed cases of type II DM and 50 healthy controls between the age group of 35-65 years were taken following inclusion and exclusion criteria. Body iron stores were assessed by measuring serum ferritin, Serum iron and Transferrin saturation and Glycemic control was assessed by measuring levels of HbA1C.
 Results: A significant increase in serum ferritin, serum iron and Transferrin saturation (P<0.001) was noted in diabetic patients as compared to controls. There was a positive correlation between serum iron and transferring saturation in the diabetic patients.
 Conclusion: The co-morbidities and complications in the Diabetic population can be prevented by monitoring Body iron stores as they can significantly contribute to the oxidative stress leading to the complication and decreased life expectancy. Early detection in the abnormality in the body iron store can help us in employing proper measures for a better management of Type-II diabetic patients and thereby improving their survival.
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Thapa, Saroj, Madhab Lamsal, Sanjay Kumar Sah, et al. "Impact of Iron Status on Thyroid Function: A Community Based Cross-Sectional Study in Eastern Nepal." Journal of College of Medical Sciences-Nepal 15, no. 1 (2019): 18–21. http://dx.doi.org/10.3126/jcmsn.v15i1.21022.
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Background: Iron deficiency is the most common nutritional deficiency in the world. The relation between thyroid hormones and iron status is bidirectional. The aim of this study was to assess iron nutrition status and evaluate its relationship with thyroid hormone profile among children of Eastern Nepal.
 Methods: A community based cross-sectional study was conducted in eastern Nepal. A total of 200 school children aged 6-12 years were recruited after taking informed consent from their guardians. Blood samples were collected and assayed for free thyroid hormones (fT3 and fT4), thyroid stimulating hormone (TSH), serum iron, total iron binding capacity (TIBC) concentration and percentage transferrin saturation was calculated.
 Results: The mean serum iron and TIBC was 74.04 µg/dl and 389.38 µg/dl respectively. The median transferring saturation was 19.21%. The overall prevalence of iron deficiency (Transferrin saturation < 16%) was 34% (n=68). The mean concentration of fT3 and fT4 was 2.87 pg/ml and 1.21 ng/dl respectively, while the median TSH concentration was 3.03 mIU/L. Median TSH concentration in iron deficient group (3.11 µg/dl) and iron sufficient group (2.91 µg/dl) was not significantly different. Among iron deficient children 5.9% had subclinical hypothyroidism (n=4). Iron status indicators were not significantly correlated with thyroid profile parameters in the study population.
 Conclusions: The prevalence of iron deficiency is high and iron deficiency does not significantly alter the thyroid hormone profile in the study region.
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Mandellos, George J., Michael N. Koukias, Ioannis St Styliadis, and Dimitrios K. Lymberopoulos. "e-SCP-ECG+Protocol: An Expansion on SCP-ECG Protocol for Health Telemonitoring—Pilot Implementation." International Journal of Telemedicine and Applications 2010 (2010): 1–17. http://dx.doi.org/10.1155/2010/137201.
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Standard Communication Protocol for Computer-assisted Electrocardiography (SCP-ECG) provides standardized communication among different ECG devices and medical information systems. This paper extends the use of this protocol in order to be included in health monitoring systems. It introduces new sections into SCP-ECG structure for transferring data for positioning, allergies, and five additional biosignals: noninvasive blood pressure (NiBP), body temperature (Temp), Carbon dioxide (CO2), blood oxygen saturation (SPO2), and pulse rate. It also introduces new tags in existing sections for transferring comprehensive demographic data. The proposed enhanced version is referred to as e-SCP-ECG+protocol. This paper also considers the pilot implementation of the new protocol as a software component in a Health Telemonitoring System.
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Singh, Satyen, Dhananjay Singh, Haneesh Thakur, Ajit Bhardwaj, and Vikas Chawla Chawla. "Air Medical Casualty Evacuation in High Altitude: An Experience of 100 Cases in High Altitude and Hilly Terrain of Northern India." Journal of Medical Sciences and Health 8, no. 2 (2022): 134–38. http://dx.doi.org/10.46347/jmsh.v8i2.21.54.
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Objectives: This article describes the on ground challenges faced by the medical care team deployed for transferring critically ill patients by air from remote locations of the high altitude and hilly terrain to definitive health care facility. Methods: All intubated critical patients requiring definitive and super specialty medical care, transferred by air from high altitude hilly terrain to tertiary care hospital during Jan 2016 to Dec year 2020, analyzed in this retrospective study. Results: The total duration of flight was between 40 – 150 min and average being 83 min. Twenty four patients were transferred by fixed wing aircraft and rest 76 by helicopters. All patient were given sedation in form of injection fentanyl 1mcg/kg in dividing doses and boluses of propofol 10 mg intravenously during transfer. The most common change noticed was fall in oxygen saturation with incidence almost 100% of the patients. The mean fall in saturation was 17.29%. Four patients required injection atropine for bradycardia which resulted with decrease of Saturation of peripheral oxygen (SpO2). Conclusion: Transferring a critically ill patient by road to distant medical centers is often not an option because of losing the golden hour of the medical care. Here comes the importance of aeromedical evacuation for a timely transfer for early medical attention. But shifting the critical patients through aerial mode requires planning and poses a variety of challenges. Keywords: Airevacuation, High altitude, Air ambulance
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Rima, Tamara, Vitayani Muchtar Sri, Amin Safruddin, Seweng Arifin, Sjahril Rizalinda, and Muhammad Adam Andi. "Serum Iron, Total Iron Binding Capacity and Transferrin Saturation Levels in Leprosy Patients before Multi Drug Therapy – World Health Organization (MDT-WHO) Compared with Healthy Control Group." International Journal of Medical Reviews and Case Reports 2, no. 4 (2018): 105–8. https://doi.org/10.5455/IJMRCR.leprosy-transferrin-saturation.
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Leprosy is an infectious disease caused by bacteria Mycobacterium leprae. This study aimed at investigating the Serum Iron, Total Iron Binding Capacity and Transferrin Saturation Levels on the leprosy patients compared with the healthy control group. This study is a continuation of previous research that has been studied Hemoglobin and Ferritin Serum Level on Leprosy Patient before Multi Drug Therapy compared with Healthy Control Group. The study was conducted in Dr. Wahidin Sudirohusodo Hospital and other hospitals in Makassar City from March to May 2018. The study used the analytic observational method with the case control study design. Samples were the leprosy patients and the control group of 18 - 52 years old who came to be treated to the dermatovenereology of Dr. Wahidin Sudirohusodo Hospital and other hospitals in Makassar City. As many as 40 samples consisted of 20 samples of the leprosy patients and 20 samples of the control group. This study shows that the iron and transferrin saturation levels in patients with leprosy are significantly lower compared to healthy population. Future studies with larger samples are needed to confirm this relationship. Iron supplementation might be considered in leprosy patients with anemia.
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Liu, Pengfei, and Liang Xiao. "A Novel Generalized Intensity-Hue-Saturation (GIHS) Based Pan-Sharpening Method With Variational Hessian Transferring." IEEE Access 6 (2018): 46751–61. http://dx.doi.org/10.1109/access.2018.2866489.
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*Dr., Naseer Ahmed Memon *Dr. Azizullah Langah *Dr. Juverya Naqvi. "COMPARISON OF SERUM IRON STATUS IN BOTTLE FED AND BREAST FED INFANTS AND ITS EVALUATION BY TRANSFERRIN SATURATION AND TOTAL IRON BINDING CAPACITY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 10 (2018): 9644–48. https://doi.org/10.5281/zenodo.1450824.
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<strong><em>Objective:</em></strong><em> To evaluate the iron status of infants who are breast fed or fed by bottle using transferring saturation and TIBC and comparison of iron status.</em> <strong><em>Study Design:</em></strong><em> This is a randomized cross-sectional study.</em> <strong><em>Place and Duration:</em></strong><em> In the Pediatrics department of People’s Medical College Hospital, Nawabshah for one year duration from October 2016 to October 2017.</em> <strong><em>Subjects and methods:</em></strong><em> Ninety infants of six to eight-month-old divided into three groups and were registered at the pediatric department of People’s Medical College Hospital, Nawabshah and were declared healthy. In addition, group I breastfeeding (human milk), group IIA milk formula was fed and group IIB animal milk was fed. Healthy infants who were reported to be healthy by the preventive pediatric care department were included in the study. Iron supplements were not included, although there were sick babies. The Performa was based on information and laboratory investigations. Standard laboratory procedures for iron, TIBC and transfer saturation were calculated.</em> <strong><em>Results:</em></strong><em> Serum TIBC was in the range of 281-303 μg / dl in lactating group I. 293.67 ± 4.73 was the mean value. In Group IIA (milk formula fed), TIBC ranged from 289.3 ± 6.06 to 280-300 μg / dl. The serum TIBC value in the IIB group (fed with animal milk) was 339-400 μg / dl with an average of 336.60 ± 10.3. The transferrin saturation in the group I was 32.1 ± 1.26 with a mean of 29-35%, in Group IIA with a mean of 35.98 ± 1.66, the mean of Group IIB of 8,52-11,84 was a mean of 32,6-39,2%, averaging 9.87 ± 0.73 .</em> <strong><em>Conclusion:</em></strong><em> The infants’ serum TIBC fed with breast milk and infants fed with formula milk were similar in the same range. The same pattern was observed in Transferrin saturation in these two groups and within normal range. In children fed by animal milk, TIBC was in a lower range with the saturation transfer. Therefore, it must be noted that the status of iron in breast-fed infants is the same as that of formula-fed infants. Iron levels are low in Babies fed with animal milk. Breastfeeding should be encouraged to prevent iron deficiency in infants.</em> <strong>Key words:</strong><em> The capacity of the unit of total inhibition of serum, status of iron, Formula Milk.</em>
Dissertations / Theses on the topic "% saturation of transferring"
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Santos, Maria do Carmo Louro Vassalo. "Iron storage disease prevalence in captive ring-tailed lemurs." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/16550.
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Dissertação de Mestrado Integrado em Medicina Veterinária<br>The present study aims to evaluate the prevalence of iron storage disease in captive ringtailed
lemurs’ populations housed in different zoological parks in Portugal and relate it to the
different diet regimens.
Eighteen animals were admitted to this study and then subdivided into three different groups,
according to their zoological institution. Blood transferrin saturation level was measured for
each animal. The diet given at each park was also analyzed and then related to the obtained
transferrin saturation values.
It was verified that transferrin saturation value is high in 89% of the animals and the mean
was higher than 55% (above the reference range) in all groups.
Despite the small sample size, it was evident that there is a high prevalence of iron storage
disease in captive ring-tailed lemurs, which seems to be strongly related to the captive diet
offered in zoological institutions.<br>RESUMO - Prevalência de iron storage disease em lémures de cauda anelada mantidos
em cativeiro - O presente estudo tem como objectivo determinar a prevalência de iron storage disease em
lémures de cauda anelada mantidos em condições de cativeiro e relacioná-la com a dieta
fornecida aos lémures em diferentes parques zoológicos, em Portugal.
Para a realização do estudo, reuniu-se uma amostra de dezoito indivíduos divididos em três
grupos, conforme o parque de onde provinham. Procedeu-se à colheita de sangue de cada
animal com posterior análise da saturação de transferrina. Foi também analisada a dieta à
qual os lémures são sujeitos em cada parque, relacionando-a mais tarde com os níveis de
saturação de transferrina obtidos.
Foi constatado que o nível de saturação de transferrina dos indivíduos analisados é elevado
em 89% dos animais, encontrando-se acima de 55% (valor máximo do intervalo de
referência) em todos os grupos.
Apesar da reduzida amostra deste estudo, existe uma forte evidência da elevada
prevalência de iron storage disease nos lémures de cauda anelada mantidos em cativeiro, o
que parece estar fortemente relacionada com a dieta oferecida a esses animais nos
respectivos parques zoológicos.<br>N/A
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Breet, Petronella. "A comparison between the effects of black tea and rooibos on the iron status of primary school children / P. Breet." Thesis, North-West University, 2003. http://hdl.handle.net/10394/172.
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Estevão, Isabeth da Fonseca [UNESP]. "Frequência dos mutantes C282Y e H63D do gene HFE e sua influência no metabolismo do ferro e na expressão da beta talassemia heterozigota." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/92482.
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estevao_if_me_sjrp.pdf: 1151592 bytes, checksum: 9e2d3a0a29b1ad6405857d13d891a9f1 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A beta talassemia é um dos mais freqüentes distúrbios genéticos no mundo. Estima-se que 1,5% a 3% da população mundial seja portadora do traço talassêmico. Esses portadores geralmente são oligo ou assintomáticos e têm uma expectativa de vida semelhante à dos não portadores. Entretanto, níveis elevados de ferritina sérica têm sido observados em alguns estudos comparativos entre beta talassemia heterozigota e não portadores e, alguns indivíduos, que nunca foram transfundidos, apresentam sinais clínicos e laboratoriais de sobrecarga de ferro. A fisiopatologia dessa complicação continua em discussão. Vários pesquisadores têm sugerido um efeito modulador da mutação do gene da beta globina e mutações em genes codificadores de proteínas relacionadas ao metabolismo do ferro. Mutações no gene HFE são as mais freqüentemente associadas à hemocromatose hereditária. O objetivo do presente trabalho foi avaliar a freqüência das mutações C282Y e H63D no gene HFE em portadores de beta talassemia heterozigota e analisar sua influência no metabolismo do ferro. Foram estudados 162 portadores de beta talassemia heterozigota, residentes na cidade de São Carlos ou região, caucasóides e, acompanhados no serviço de Hematologia. O diagnóstico de traço talassêmico foi confirmado em todos por meio do eritrograma e da quantificação da Hb A2 e Hb fetal por HPLC. O metabolismo do ferro foi avaliado pelas dosagens de ferro sérico, capacidade total de ligação do ferro, ferritina e saturação da transferrina e, a análise molecular das mutações no gene HFE, pela técnica de PCR-RLFP. Foram realizadas análises de correlação linear de Pearson por idade e gênero entre hemoglobina...<br>Beta thalassemia is one of the most frequent genetic disorder in the world. It is estimated that 1.5% to 3% of the world population is a thalassemia carrier. These individuals are generally slightly symptomatic or asymptomatic and they have a life expectancy similar to those who are non-carriers. However, high levels of serum ferritin have been observed in some comparative studies between heterozygous for beta thalassemia and non-carriers, and some individuals that were never transfused, present clinic and laboratories signs of iron overload. The physiopathology of this disease continues in discussion. Several researchers have suggested a modulator effect from the mutation of the beta globin gene and mutations in genes related with the iron metabolism. Mutations of the gene HFE are the most frequently associated to the hereditary hemochromatosis. The aim of this study was evaluate the frequency of C282Y and H63D mutations in the HFE gene in beta thalassemia carriers, and analyze its influence in the iron metabolism. 162 beta thalassemia carriers, Caucasoid, residing in the city of Sao Carlos or region and accompanied in the Hematology service were studied. The diagnostic of thalassemia trait was confirmed in every one through a complete erythrogram and quantification of Hb A2 and Hb fetal by HPLC. The iron metabolism was evaluated by serum iron, total iron-binding capacity, serum ferritin and percent saturation of transferring. The molecular analysis of the mutations in the HFE gene was made by PCR-RLFP. There were made analysis of linear Pearson’ correlation, by age and gender, among hemoglobin, Hb A2, VCM and among reticulocytes count and the values of saturation of transferrin and serum ferritin.
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Estevão, Isabeth da Fonseca. "Frequência dos mutantes C282Y e H63D do gene HFE e sua influência no metabolismo do ferro e na expressão da beta talassemia heterozigota /." São José do Rio Preto : [s.n.], 2007. http://hdl.handle.net/11449/92482.
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Resumo: A beta talassemia é um dos mais freqüentes distúrbios genéticos no mundo. Estima-se que 1,5% a 3% da população mundial seja portadora do traço talassêmico. Esses portadores geralmente são oligo ou assintomáticos e têm uma expectativa de vida semelhante à dos não portadores. Entretanto, níveis elevados de ferritina sérica têm sido observados em alguns estudos comparativos entre beta talassemia heterozigota e não portadores e, alguns indivíduos, que nunca foram transfundidos, apresentam sinais clínicos e laboratoriais de sobrecarga de ferro. A fisiopatologia dessa complicação continua em discussão. Vários pesquisadores têm sugerido um efeito modulador da mutação do gene da beta globina e mutações em genes codificadores de proteínas relacionadas ao metabolismo do ferro. Mutações no gene HFE são as mais freqüentemente associadas à hemocromatose hereditária. O objetivo do presente trabalho foi avaliar a freqüência das mutações C282Y e H63D no gene HFE em portadores de beta talassemia heterozigota e analisar sua influência no metabolismo do ferro. Foram estudados 162 portadores de beta talassemia heterozigota, residentes na cidade de São Carlos ou região, caucasóides e, acompanhados no serviço de Hematologia. O diagnóstico de traço talassêmico foi confirmado em todos por meio do eritrograma e da quantificação da Hb A2 e Hb fetal por HPLC. O metabolismo do ferro foi avaliado pelas dosagens de ferro sérico, capacidade total de ligação do ferro, ferritina e saturação da transferrina e, a análise molecular das mutações no gene HFE, pela técnica de PCR-RLFP. Foram realizadas análises de correlação linear de Pearson por idade e gênero entre hemoglobina... (Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: Beta thalassemia is one of the most frequent genetic disorder in the world. It is estimated that 1.5% to 3% of the world population is a thalassemia carrier. These individuals are generally slightly symptomatic or asymptomatic and they have a life expectancy similar to those who are non-carriers. However, high levels of serum ferritin have been observed in some comparative studies between heterozygous for beta thalassemia and non-carriers, and some individuals that were never transfused, present clinic and laboratories signs of iron overload. The physiopathology of this disease continues in discussion. Several researchers have suggested a modulator effect from the mutation of the beta globin gene and mutations in genes related with the iron metabolism. Mutations of the gene HFE are the most frequently associated to the hereditary hemochromatosis. The aim of this study was evaluate the frequency of C282Y and H63D mutations in the HFE gene in beta thalassemia carriers, and analyze its influence in the iron metabolism. 162 beta thalassemia carriers, Caucasoid, residing in the city of Sao Carlos or region and accompanied in the Hematology service were studied. The diagnostic of thalassemia trait was confirmed in every one through a complete erythrogram and quantification of Hb A2 and Hb fetal by HPLC. The iron metabolism was evaluated by serum iron, total iron-binding capacity, serum ferritin and percent saturation of transferring. The molecular analysis of the mutations in the HFE gene was made by PCR-RLFP. There were made analysis of linear Pearson' correlation, by age and gender, among hemoglobin, Hb A2, VCM and among reticulocytes count and the values of saturation of transferrin and serum ferritin.<br>Orientador: Claudia Regina Bonini Domingos<br>Coorientador: Antonio José Manzato<br>Banca: Celso Carlos de Campos Guerra<br>Banca: Paula Rahal Liberatore<br>Mestre
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Cullen, Lara Michelle. "Molecular analysis of hereditary haemochromatosis." Thesis, Queensland University of Technology, 1999.
Find full textBooks on the topic "% saturation of transferring"
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Macdougall, Iain C. Iron management in renal anaemia. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0126.
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Although erythropoiesis-stimulating agent therapy is the mainstay of renal anaemia management, maintenance of an adequate iron supply to the bone marrow is also pivotal in the process of erythropoiesis. Thus, it is important to be able to detect iron insufficiency, and to treat this appropriately. Iron deficiency may be absolute (when the total body iron stores are exhausted) or functional (when the total body iron stores are normal or increased, but there is an inability to release iron from the stores rapidly enough to provide a ready supply of iron to the bone marrow). Several markers of iron status have been tested, but those of the greatest utility are the serum ferritin, transferrin saturation, and percentage of hypochromic red cells. Measurement of serum hepcidin, which is the master regulator of iron homoeostasis, has to date proved disappointing as a means of detecting iron insufficiency, and none of the available iron markers reliably exclude the need for supplemental iron. Iron may be replaced by either the oral or the intravenous route. In the advanced stages of chronic kidney disease, however, hepcidin is upregulated, and this powerfully inhibits the absorption of iron from the gut. Thus, such patients often require intravenous iron, particularly those on dialysis. Several intravenous (IV) iron preparations are available, and they have in common a core containing an iron salt, surrounded by a carbohydrate shell. The IV iron preparations differ in their kinetics of iron release from the iron–carbohydrate complex. In recent times, several new IV iron preparations have become available, and these allow a greater amount of iron to be given more rapidly as a single administration, without the need for a test dose.
Book chapters on the topic "% saturation of transferring"
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Oehlmann, Niels N., and Johannes G. Rebelein. "Generating Site Saturation Mutagenesis Libraries and Transferring Them to Broad Host-Range Plasmids Using Golden Gate Cloning." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-4220-7_14.
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de Jong, G., W. L. van Noort, and H. G. van Eijk. "Optimized Separation and Quantitation of Serum and Cerebrospinal Fluid Transferrin Subfractions Defined by Differences in Iron Saturation or Glycan Composition." In Advances in Experimental Medicine and Biology. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2554-7_6.
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Elsayed, M. E., M. U. Sharif, and A. G. Stack. "Transferrin Saturation." In Advances in Clinical Chemistry. Elsevier, 2016. http://dx.doi.org/10.1016/bs.acc.2016.03.002.
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Mukhopadhyay, Adwitiya, Sidharth Sreekumar, Bobin Xavier, and Suraj M. "A Cloud-Based Smartphone Solution for Transmitting Bio-Signals From an Emergency Response Vehicle." In Research Anthology on Telemedicine Efficacy, Adoption, and Impact on Healthcare Delivery. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-8052-3.ch022.
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Most developing countries are currently unable to provide adequate, let alone advanced healthcare support to rural areas. Telemedicine combines the capability of information technology and dedicated people working towards the common goal of providing good quality healthcare in remote areas. In this article, the authors propose a system that can be used to transmit patient vitals like pulse rate, oxygen saturation, and perfusion index readings to a doctor in a remote area, while a patient is in transit. This system uses a smartphone application, a pulse oximeter, and the real-time data transferring capabilities of Firebase (a cloud database). The application has been tested under various network conditions which includes connection types such as 2G (2nd Generation), 3G (3rd Generation), 4G (4th Generation), and Fiber To The Home (FTTH). The work also discusses the possible reasons for the higher performance found in 4G networks over 3G and 2G cellular connections.
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Gutteridge, J. M. C., and S. Mumby. "Plasma unsaturated iron-binding capacity and percent saturation of transferrin." In Experimental protocols for reactive oxygen and nitrogen species. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780198506683.003.0049.
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Abstract The unsaturated iron-binding capacity (UIBC) of plasma is a measure of the available capacity of plasma to bind iron. Total iron-binding capacity (TIBC) is a measure of all the iron bound to transferrin when it has been fully saturated by adding iron.
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Weatherall, D. J. "Normochromic, normocytic anaemia." In Oxford Textbook of Medicine. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.220505_update_001.
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A mild normochromic, normocytic anaemia is a common finding and usually a consequence of other diseases, including (1) anaemia of chronic disorders—associated with chronic infection, all forms of inflammatory diseases, and malignant disease; mechanism unknown but likely to involve multiple factors; typically leads to a reduction in the serum iron concentration with concurrent reduction in the level of transferrin, hence saturation of the iron binding capacity is usually normal or only slightly reduced; (2) other disorders—including renal failure, hypothyroidism, hypopituitarism, marrow failure (aplastic anaemia, infiltration, pure red-cell aplasia), acute blood loss, and polymyalgia rheumatica. Treatment is that of the underlying condition, with a therapeutic trial of corticosteroids justified—after exclusion of underlying blood dyscrasias and paraproteinaemias—in elderly patients with anaemia in association with a very high sedimentation rate....
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Nadar Indrasari, Yulia, Siti Nurul Hapsari, and Muhamad Robiul Fuadi. "Potential Marker for Diagnosis and Screening of Iron Deficiency Anemia in Children." In Iron Metabolism - Iron a Double‐Edged Sword [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102792.
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Iron plays a role in multiple physiological functions, naming oxygen transport, gene regulation, DNA synthesis, DNA repair, and brain function. Iron deficiency anemia (IDA) may happen following iron deficiency, but iron deficiency alone may cause negative impacts on the health risk of pediatric patients. The degree of iron deficiency is described by total body iron (measured by ferritin), transport iron (measured by transferrin saturation), serum iron, and other hematologic and biochemical markers. Iron deficiency anemia is a result of insufficient iron supply causing the inability to maintain normal levels of hemoglobin. The most common causes of microcytic anemia in children are iron deficiency and thalassemia minor. There are various hematologic and biochemical parameters used for screening and diagnosis of iron deficiency anemia in children, but there is no single “best” test to diagnose iron deficiency with or without anemia. The “gold standard” for identifying iron deficiency is a direct test-bone marrow biopsy with Prussian blue staining. This article aims to explain iron metabolism in children and discuss the role of hematologic and biochemical parameters for screening and diagnosis of iron deficiency anemia in children.
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Jankowska, Ewa A., Stefan D. Anker, and Piotr Ponikowski. "Iron deficiency in heart failure." In The ESC Textbook of Heart Failure, edited by Petar M. Seferović, Andrew J. S. Coats, Gerasimos Filippatos, Stefan D. Anker, Johann Bauersachs, and Giuseppe Rosano. Oxford University PressOxford, 2023. http://dx.doi.org/10.1093/med/9780198891628.003.0076.
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Abstract Abstract: Iron deficiency (ID) is an ominous non-cardiovascular co-morbidity highly prevalent in patients with heart failure (HF). The presence of ID in patients with HF, regardless of concomitant anaemia, translates into exaggerated HF symptoms, impaired exercise capacity, poor quality of life, frequent recurrent HF hospitalizations, high mortality and increased healthcare costs. ID is diagnosed in patients with HF when serum ferritin is &lt; 100 ng/mL (ng/mL = μg/L), or when serum ferritin is between 100 and 299 ng/mL combined with a transferrin saturation (TSAT) of &lt; 20% (TSAT = (iron/TIBC) × 100%). According to the ESC guidelines on HF (2016, 2021), all patients with HF are recommended to be screened for ID using serum ferritin and TSAT, regardless of left ventricular ejection fraction (LVEF), haemoglobin level and kidney function. The results of the FAIR-HF, CONFIRM-HF, and AFFIRM-AHF trials along with meta-analyses have established the basis for the ESC recommendation that intravenous iron supplementation with ferric carboxymaltose (FCM) should be considered in symptomatic patients with LVEF &lt;45% and ID (defined as above) in order to alleviate HF symptoms, improve exercise capacity and quality of life. The major results of the AFFIRM-AHF trial have led the foundations for the recommendation that intravenous iron supplementation with FCM should be considered in symptomatic HF patients recently hospitalized for HF and with LVEF &lt; 50% and ID (defined as above) in order to reduce the risk of HF hospitalization. Therapy with FCM has been demonstrated to be effective and safe. Cost-effectiveness analysis has confirmed that intravenous iron supplementation with FCM in iron deficient patients after an episode of acute HF is dominant in the UK, USA, and Switzerland, and is highly cost-effective in Italy. Ongoing clinical trials are expected to provide further evidence on the effect of this therapy on long-term cardiovascular mortality in iron deficient patients with HF (FAIR-HF2, IRONMAN, HEART-FID) and on exercise capacity and quality of life in iron deficient patients with HF with preserved ejection fraction (FAIR-HFpEF).
Conference papers on the topic "% saturation of transferring"
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Morgan, N. R., C. N. Ammerman, J. R. Sims, S. Konecni, and J. C. Wilson. "Multiphase Cooling of High Frequency Conductors Encased in a Porous Medium." In ASME 2003 Heat Transfer Summer Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/ht2003-47492.
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This study presents a new method for cooling high frequency conductors requiring substantial structural support. This new method of cooling involves boiling a dielectric, fluorinert™ refrigerant that is in direct contact with the supported conductor. A porous, dielectric medium was created for structural support with enough interconnected voids to sustain liquid-vapor flow. A pool boiling test chamber was constructed to investigate the heat transfer characteristics of a conductor encased in a porous medium. The conductor-porous media assembly was mounted horizontally on two conductor posts and submerged into the liquid. The tests were performed using support structures with different interconnected void sizes. A DC power supply was used to apply heat to the conductor and all tests were performed at the saturation temperature. Critical heat flux was captured and each assembly evaluated for best performance in transferring heat. The results from these experiments will enhance the cooling technology used in high frequency conductor applications.
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Yu, Xichong, Li Gang, Weixin Pang, and Wu Yaling. "Heat and Mass Transfer Mechanism of Gas Hydrate Development for South China Sea." In ASME 2014 33rd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/omae2014-23202.
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The decomposition process of gas hydrate in sediments is actually the dynamic phase transition process of solid hydrate in sediments after absorbing heat decomposition. According to the phase equilibrium characteristics of gas hydrate, there are three basic development methods, including heating, chemical injecting and depressurization. Currently, there is no good commercial software used to simulate heat transmission and mass transfer in the gas hydrate decomposition process. So in this paper, based on typical gas hydrate sediment in South China Sea, microcosmic, mesocosmic (fractal theory) and macrocosmic scales are respectively used to successfully reveal the heat and mass transfer mechanism of three basis development methods. Molecular dynamics simulation shows heat injection is the best method for heat and mass transferring, and chemical injecting is better than depressurization. Fractal theory is successfully used to describe the complex structure of the porous sediments with gas hydrate occurrence, and can realize the prediction of heat and mass transfer law of hydrate dissociation in porous media. Macrocosmic numerical simulation of depressurization for gas hydrate sediment in South China Sea shows gas hydrate reservoir geological model has a large influence on the gas hydrate decomposition, and permeability and hydrate saturation of the upper cover layer have great effect on gas hydrate decomposition. It is poor development efficiency for only depressurization development and the problem of water drainage should be paid attention during development process.
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Huang, Jiangshui, Lijun Lin, Genyao Lin, et al. "Measurement of the Static Proppant-Settling Velocity in Fracturing Fluids Through Digital Image Analysis." In SPE Annual Technical Conference and Exhibition. SPE, 2023. http://dx.doi.org/10.2118/214965-ms.
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Abstract This paper presents a novel method for quantitatively measuring the static proppant-settling velocity in hydraulic fracturing fluids through digital image analysis. The method developed is reliable and efficient for measuring the static proppant settling velocity (Sv) when there is no clear settling interface, which is useful for comparing the proppant carrying capability of different friction reducers (FRs), optimizing the concentration of friction reducers in the fracturing fluids for field operations, and improving the proppant carrying capability of friction reducers through the synthesis process. The experimental procedure involves pouring a fracturing fluid with proppants into a transparent glass cylinder, taking images of the proppants settling using a camera, transferring the images into a computer, and analyzing the images using macro programs prepared to measure the static proppant settling velocity. The settling velocity is determined by measuring the position (height) change of a proppant concentration selected with time, which is realized through using image saturation to determine the position of the proppant concentration in the image analysis. The results obtained from this method show that the proppant size, friction reducer concentration, salinity of the friction reducer fracturing fluids, and friction reducer molecule weight and chemical structure have an impact on the static proppant settling velocity. Also, the method developed in this study can be helpful for selecting proper fracturing fluids for field applications and the optimization of friction reducers in the synthesis process through quantitatively measuring the settling velocity. To the best of our knowledge, except for determining the settling velocity of a single particle in the fluids, this is the first study to quantitatively measure the static proppant-settling velocity in fracturing fluids through digital image analysis. The method developed offers several benefits including the ability to measure the settling velocity in real-time, low cost, and ease of implementation even when there is no clear settling interface. The results obtained from this method provide valuable insights into the transport behavior of proppants in fracturing fluids, enabling better design of hydraulic fracturing treatments to improve the recovery of oil and gas.
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Sibgatullin, I., S. Elistratov, and X. Xu. "Instabilities and Attractors in Large Aspect Ratio Stratified/Rotating Fluids." In Topical Problems of Fluid Mechanics 2023. Institute of Thermomechanics of the Czech Academy of Sciences; CTU in Prague Faculty of Mech. Engineering Dept. Tech. Mathematics, 2023. http://dx.doi.org/10.14311/tpfm.2023.025.
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Internal and inertial waves are ubiquitous in the world’s oceans, and the energy that they transfer from the global tide to the smaller scales may impact the vertical mixing and global currents. The dynamics of internal and inertial waves in closed domains possesses a remarkable property of self-focusing on geometrical limit cycles called wave attractors. The significant growth of wave amplitude at the wave attractors results in instabilities for viscous fluids. The scenarios of the transition to turbulence and the description of the fully turbulent regimes differ substantially from the cases observed in closed domains in the absence of wave attractors. Our previous studies demonstrated the key role of a cascade of triadic resonances as the route to fully developed wave turbulence, either with overturning events or not. Presently we consider a shallow trapezoid and the wave attractors that form after multiple reflections from the horizontal boundaries. The saturation time of (n,1) wave attractors in laminar viscous fluids grows linearly with n if the wavemaker is located at the sidewall. Next we show that in a shallow elongated domain with small aspect (depth-to-length) ratio, the frequency spectrum of (1,1) wave attractor motion may exhibit significant peaks at integer and halfinteger multiples of the forcing frequency. For an aspect ratio of about one tenth the temporal average of the total kinetic energy grows monotonically with the amplitude and exhibits a bend at a particular amplitude. Below this amplitude the cascade transferring energy to integer superharmonic components prevails, while above it the amplitudes of waves at integer and half-integer multiples of the forcing frequency are comparable. The spatial spectra of the waves are compared for domains of aspect ratio varying from small values to values close to unity. It is shown that in the former case (i.e. for elongated shallow domains) the spectrum exhibits two zones at small and high wave numbers characterized by different slopes. The fully turbulent regimes show a trend toward a long-term evolution leading to new regimes with a complex resonant dynamics of large-scale coherent structures.
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Abdel Noor, R. A., M. H. Abu-Zaid, S. A. Elshweikh, E. S. Rabee, and G. E. Khedr. "FRI0081 The importance of transferrin saturation, serum ferritin, log ferritin and transferrin/log ferritin in differentiating iron deficiency anaemia from anaemia of chronic disease in rheumatoid arthritispatients." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.3969.
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Ferreira, ACA, PS Neves, BDN Fonseca, et al. "ANÁLISE DA INFLUÊNCIA DE FATORES PRÉ ANALÍTICOS NAS DOSAGENS DE FERRO SÉRICO, CAPACIDADE TOTAL DE LIGAÇÃO DO FERRO, ÍNDICE DE SATURAÇÃO DA TRANSFERRINA E FERRITINA." In Resumos do 55º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s2.8727.
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Objetivo: Identificar os fatores pré-analíticos envolvidos na dosagem de ferro, ferritina, IST e CTLF, como ritmo circadiano, prática de atividade física e realização ou não de jejum para minimizar as possíveis variações associadas. Método: Foram selecionados 80 voluntários adultos, de ambos os sexos, com idade entre 18 e 60 anos para participarem da pesquisa. A coleta das amostras foi realizada no laboratório, e os voluntários foram submetidos a quatro coletas de sangue. Após as coletas, as amostras foram mantidas sob refrigeração entre 2ºC e 8ºC; em seguida, elas foram transportadas até o laboratório. A dosagem de ferro sérico, ferritina, índice de saturação da transferrina e capacidade total de ligação do ferro foi realizada pelo método colorimétrico enzimático, e de ferritina, pelo método de imunoturbidimetria. Conclusão: O presente estudo possibilitou identificar duas variáveis analíticas que influenciam nos valores do ferro sérico, como o jejum e o ciclo circadiano. Referências: 1. Guyatt GH, Oxman AD, Ali M, Willan A, McIlroy W, Patterson C. Laboratory diagnosis of iron-deficiency anemia. J Gen Intern Med. 1992 Mar; 7(2): 145-53. 2. Lippi G, Becan-McBride K, Behúlová D, Bowen RA, et al. Preanalytical quality improvement: in quality we trust. Clin Chem Lab Med (CCLM) [Internet]. 2013 Jan 1; 51(1): 229-41. Disponível em: https://www.degruyter.com/view/journals/cclm/51/1/articlep229.xml?tab_body=abstract. 3. Dale JC, Burritt MF, Zinsmeister AR. Diurnal variation of serum iron, iron-binding capacity, transferrin saturation, and ferritin levels. Am J Clin Pathol [Internet]. 2002 May 1 [citado em 23 fev 2021]; 117(5): 802-8. Disponível em: https://academic.oup.com/ajcp/article/117/5/802/1758685?login=true. 4. Høyer K. Physiologic variations in the iron content of human blood serum. Acta Med Scandinavica. 2009;119(6): 562-76.
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Kobelkova, Irina Vitalievna, Margarita Mikhailovna Korosteleva, Dmitry Borisovich Nikityuk, et al. "DEVELOPMENT OF A SPECIALIZED FOOD PRODUCT FOR THE PREVENTION OF IRON DEFICIENCY ANEMIA IN JUNIOR ATHLETES." In NEW TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2021. http://dx.doi.org/10.47501/978-5-6044060-1-4.34.
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The prevalence of iron deficiency in female athletes varies significantly, with 31% having a ferritin concentration below 12 ng/ml or a transferrin saturation of less than 16 ng/ml. The medical and biological substantiation of the composition was carried out and a specialized food product was developed for nutrition of female athletes of children and adolescents (12-17 years), that provides the intake an easily digestible of hem form’s iron and vitamins involved in iron metabolism in the body for at least 15 % and no more than 50% of the recommended daily intake.
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Agarwal, Binayak, Kavish Grover, and Qassim Riyami. "Integrated Uncertainty Modelling Workflow – A Phenomenological Approach." In SPE Advances in Integrated Reservoir Modelling and Field Development Conference and Exhibition. SPE, 2025. https://doi.org/10.2118/225408-ms.
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Abstract The success of hydrocarbon maturation projects hinges on three key factors: making informed decisions, managing uncertainty, and addressing risks. Effective management of uncertainty is crucial because of the complex risks posed by geological, technical, economic, and environmental factors. To manage these uncertainties well, it is important to identify, evaluate, and mitigate risks throughout the entire lifecycle of the project. A crucial component of managing uncertainty is integrated subsurface uncertainty modeling. This approach involves several key elements: (a) Geological Data: Understanding the structure, types of rock (facies), and distribution of resources; (b) Geophysical Data: Analyzing seismic data and well logs to understand subsurface conditions.; (c) Petrophysical Data: Assessing rock properties and characteristics; (d) Dynamic Aspects: Using simulations and historical data matching to predict reservoir behavior. To manage uncertainties effectively, these elements need to be combined through coordinated strategies. This involves integrating data from various sources, using probabilistic and stochastic modeling, and continually refining models through iterative processes. By doing so, companies can create more accurate and reliable subsurface models, reduce uncertainties, and make better decisions, leading to improved project outcomes. However, traditional methods often involve using different tools for each aspect of subsurface data analysis and modeling. This usually requires transferring data between tools, which can take between 4 to 15 weeks of man-hours. The industry has recognized this issue, and some have moved towards integrated workflows that use single applications for these tasks. But this solution may not be ideal for every situation or company. The current study introduces a new approach to uncertainty modeling. This method uses available applications to create an automated and dynamic workflow that integrates different elements of uncertainty modeling. It allows for a more thorough exploration and quantification of uncertainties while reducing the need for manual work and speeding up data processing. This approach not only saves time but also lowers the chance of human error, resulting in more reliable subsurface models and faster project development. The approach is built on principles of surrogate modeling, utilizes high fidelity reservoir simulation model in the core ensuring accurate modeling of fluid flow physics and the workflow is augmented with application of designs of experiment and neural networks to achieve envelope of uncertainty in reasonable time. To enhance flexibility in the scale of development, the workflow encompasses a method for deconvoluting the uncertainty envelope specific to subsets of reservoir characterization. The integration is achieved through pre simulation scripting to enable automatic updates to the geomodel within the dynamic simulation model. A neural network proxy model performs statistical variance analysis on simulation outputs to identify parameters most affecting the development goal, such as optimizing oil recovery. A given field "A" with limited data and numerous uncertainty parameters affecting subsurface outcomes is used in this study. Key critical uncertainties include the lateral continuity of the reservoir, log interpretation, saturation height function, and well productivity.
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Esteban, Jorge Illarramendi, Montserrat Alvarellos, Mercedes Rodriguez, Amaya Zabalza, and José Juan Illarramendi. "IRON OVERLOAD IN A BREAST CANCER PATIENT WITH A HOMOZYGOUS MUTATION IN THE HFE HEMOSTATIC IRON REGULATOR GENE: CONSIDERATIONS REGARDING THE USE OF ADJUVANT HORMONE THERAPY." In Brazilian Breast Cancer Symposium 2022. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s2082.
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Introduction: Homozygous mutations in the HFE gene are among the causes of iron overload worldwide. Several reports suggest an increased risk of breast cancer (BC) in these patients, although there are controversial evidences on this subject. There is some discussion on the tolerance to some BC adjuvant therapies in these patients regarding aspects like the potential cardiotoxicities. Information on adjuvant hormone therapy in this setting is very limited. Case report: A 65-year- -old woman was treated with segmental resection in the left breast and selective biopsy of the sentinel node in April 2019. Pathology showed an infiltrating ductal carcinoma of 1.2 cm, grade 1, with two negative sentinel nodes. Estrogen receptor was 100%, progesterone receptor was 20%, Her2/neu was 1+, and Ki-67 was 15%. A previous diagnosis of hemochromatosis was done in October 2018 with a high transferrin saturation and a genetic analysis disclosing a homozygous C282Y mutation in the HFE gene. Regular phlebotomies every 3 months were scheduled for the treatment of the iron overload. Several points were considered for the selection of the adjuvant hormone therapy. Articular damage is a common complication of hemochromatosis. In fact, a hip prosthesis was implanted in 2018 for our patient with severe coxarthrosis. There was some risk of further articular impairment with aromatase inhibitors (AI). Furthermore, AI may have an androgenic effect, with some effect on the red cell mass. On the contrary, tamoxifen may increase the risk of porphyria crises in patients with hemochromatosis. We selected letrozole as adjuvant therapy, with good articular tolerance and fair hematological control after nearly 3 years of follow-up. Conclusion: Although homozygous HFE mutations may increase the risk of some adverse events related to BC adjuvant hormone therapy, the tolerance to letrozole in our patients has been very good, without raising further concerns.