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Journal articles on the topic 'Schiffs Bases 4-Thiazolidinone Derivatives Anti-Convulsant Activity'

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Published: 5 June 2025

Last updated: 2 August 2025

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1

Dr., Faizan Sayeed1* Abdul Sayeed1 MD Akram1 Mohd Waseem Akram2. "DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW SUBSTITUTED THIAZOLIDIN-4- ONE DERIVATIVES." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2461–72. https://doi.org/10.5281/zenodo.846845.

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4-thiazolidinones are among t h e most extensively investigated class of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities.They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial,anti-HIV,CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, it was thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleu

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2

Dr.Faizan, Sayeed* Abdul Sayeed1 MD Akram Mohd Waseem Akram. "ANALGESIC AND ANTI INFLAMMATORY ACTIVITY OF NEW SUBSTITUTED THIAZOLIDIN-4-ONE DERIVATIVES." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2449–60. https://doi.org/10.5281/zenodo.846843.

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4-thiazolidinones are among t he most extensively investigated class of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities.They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial,anti-HIV,CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, itwas thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleus

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3

Abu-Hashem, Ameen Ali, Khadiga Mohamed Abu-Zied, Magdi Elsayed AbdelSalam Zaki, Mohamed Fathy El-Shehry, Hanem Mohamed Awad, and Mohammed Abdou Khedr. "Design, Synthesis, and Anticancer Potential of the Enzyme (PARP-1) Inhibitor with Computational Studies of New Triazole, Thiazolidinone, - Thieno [2, 3-d] Pyrimidinones." Letters in Drug Design & Discovery 17, no. 6 (2020): 799–817. http://dx.doi.org/10.2174/1570180817666200117114716.

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Background: Thienopyrimidine, triazole and thiazolidinone derivatives have recently gained attention due to their effective pharmacological activities. They show antioxidant, antitumor, antimicrobial, antiviral, anti-inflammatory and analgesic properties. Objective: Synthesis of new ethyl 2-amino-4-isopropyl-5-methylthiophene-3-carboxylate (2) was used as a starting material to produce 2-mercapto-methylthienopyrimidinone (3), (4) and 2- hydrazinyl-methylthienopyrimidinone (5), through high yields and evaluating anticancer activities. Method: A series of novel Schiff's bases (6-9) were produced

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C., Mallikarjunaswamy*1 V. Lakshmi Ranganatha2 L. Mallesha1 D.G. Bhadregowda3. "NOVEL PYRIMIDINE SCHIFF BASES: SYNTHESIS AND PHARMACOLOGICAL SCREENING." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7329–39. https://doi.org/10.5281/zenodo.1005166.

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Schiff bases are aldehydelike compounds in which an imine group replaces the carbonyl group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This study represents the synthesis of a new series of (E) -N-benzylidene-5-bromo-2-chloropyrimidin-4-amine derivatives (6a-l). The newly synthesized compounds were characterized by different spectral studies. All these new compounds screened for their anti-inflammatory, antimicrobial and in vitro antioxidant activities. Structure–activity relationship analysis demonstrates that hydroxyl groups on the

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Amić, Ana, and Elena Gotal. "Selected Thermodynamic Parameters of Antioxidant Activity of Coumarin Based Heterocyclic Compounds." Chemistry Proceedings 3, no. 1 (2020): 109. http://dx.doi.org/10.3390/ecsoc-24-08385.

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Coumarin and coumarin derivatives are bioactive compounds that have an important role in medicinal chemistry, for example in the development of anti-inflammatory, anticancer and antiviral drugs. These compounds are also very powerful antioxidants that successfully scavenge free radicals and prevent or alleviate oxidative stress. The antioxidant potential of selected heterocyclic compounds containing coumarin core was investigated theoretically, the focus of this study was on hydrogen atom transfer mechanism (HAT) and single electron transfer followed by a proton transfer mechanism (SET-PT). Us

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Premlata, Gupta, Jat Kamal, Singh Solanki Vijendra, and Shrivastava Ruchi. "An efficient synthesis, characterization and biological activity of novel Schiff bases of 2-aryl-1H-benzo[d]imidazole-4-carbohydrazide derivatives." Journal of India Chemical Society Vol. 95, Feb 2018 (2018): 173–79. https://doi.org/10.5281/zenodo.5638706.

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Department of Chemistry IPS Academy, Indore-452 012, Madhya Pradesh, India E-mail : drpremlataguptachem@gmail.com <em>Manuscript received 20 December 2017, revised 31 January 2018, accepted 19 February 2018</em> A series of <em>N'</em>-aryllidene-2-aryl-1<em>H</em>-benzo[<em>d</em>]imidazole-4-carbohydrazide (Schiff bases) 3a<sub>1</sub>-3d<sub>4</sub> were synthesized by condensation reaction of 2-aryl-1<em>H</em>-benzo[<em>d</em>]imidazole-4-carbohydrazide (2a-2d) with substituted aromatic aldehyde. The characterization of all these novel synthesized compounds 3a<sub>1</sub>-3d<sub>4</su

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Rani, U. Usha, and A. Sreedevi. "Synthesis and Biological Evaluation of 3-(2-Benzoyl-4-chlorophenyl)-4H-spiro [indole-3,2-[1,3]thiazolidine]-2,4(1H)- dione Derivatives for Anti-tubercular and Antimicrobial Activities." Indian Journal Of Science And Technology 17, no. 20 (2024): 2101–9. http://dx.doi.org/10.17485/ijst/v17i20.1434.

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Objectives: To synthesize a new scaff fold of 3'-(2-Benzoyl-4-chlorophenyl)-4'H-spiro [indole-3,2'-[1,3] thiazolidine]-2,4'(1H)-dione derivatives and to assess the compounds for anti-tubercular and antimicrobial activities. Methods : A new series of 3'-(2-Benzoyl-4-chlorophenyl)-4'H-spiro [indole-3,2'- [1,3] thiazolidine]-2,4'(1H)-dione derivatives were prepared by synthesizing schiff’s bases followed by condensing schiff base with 2-mercaptopropanoic acid in the presence of zinc chloride. Synthesized compounds were characterized by IR, NMR and Mass spectral data. Their antimicrobial, antitube

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8

Somani, R., P. Dubey, and S. Zine. "MICROWAVE ASSISTED SYNTHESIS OF BIPHENYL BASED SCHIFF’S BASES AND THEIR ANTIMICROBIAL EVALUATION." INDIAN DRUGS 55, no. 03 (2018): 13–18. http://dx.doi.org/10.53879/id.55.03.11218.

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Schiff’s base constitutes a significant class of compounds for new drug development. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The search for Schiff’s base containing compounds with more selective activity and lower side effects continues to be an active area of argument examination in medicinal chemistry. The biphenyl molecule consists of two connected phenyl rings. Biphenyl ring scaffolds are fairly non-reactive in nature. They enhance the log-P values; increase the tropical polar surface area (TPSA) of the molecule, act as hydropho

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9

Sumathy, A., R. Suresh, and N. L. Gowrishankar. "In-silico DESIGN SCREENING OF SOME PYRAZOLONE FUSED HETEROCYCLIC ANALOGUES AS HER2 INHIBITORS TARGETING BREAST CANCER." Rasayan Journal of Chemistry 15, no. 01 (2022): 497–503. http://dx.doi.org/10.31788/rjc.2022.1516738.

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In human breast cancers, the human epidermal development factor receptor-2 is a membrane tyrosine kinase that is overexpressed, and gene amplified. Pyrazolone fused heterocyclic moieties- thiazolidinone, carboxymethyl thiazolidinone, azetidinone are significant DNA-intercalating agents here human epidermal development factor receptor-2 amplification and over expression are linked to tumour cell proliferation and the pathway of instances in breast cancer. Few novel pyrazolone fused heterocyclic analogues are designed by in-silico-technique for their human epidermal development factor receptor-2

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Padmaja, Devi M. S* Dr. Prasobh G.R. Dr. Sandhya S.M Visal C. S. Reena Athira. "SYNTHESIS AND SCREENING OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL BENZTRIAZOLE DERIVATIVES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 07 (2019): 13632–48. https://doi.org/10.5281/zenodo.3345871.

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<em>Benzotriazole is a  lead molecule for designing potential bioactive molecule. Benzotriazole and its derivatives exhibits anti inflammatory, analgesic, antimicrobial and anticonvulsant activities. 1,2,4 triazole is one of the most biologically active classes of compounds possessing wide spectrum of activities including anti-inflammatory, analgesic, CNS stimulants, sedatives, antianxiety, antimicrobial agents and antimycotic agents. In this study, we planned to synthesize various Schiff’s bases of 5 [1H,1,2,3 benzotriazol 1yl methyl] 4 [substituted amino]4H-1,2,4 triazole-3 &ndash

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Biswa, Mohan Sahoo, Nagamounika K., and Krishna Banik Bimal. "Microwave-assisted synthesis of Schiff's bases of 1,2,4-triazole derivatives and their anthelmintic activity." Journal of Indian Chemical Society Vol. 95, Nov 2018 (2018): 1289–94. https://doi.org/10.5281/zenodo.5652476.

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Department of Pharmacy, Vikas Group of Institutions, Nunna, Krishna District, Vijayawada-521 229, Andhra Pradesh, India E-mail: drbiswamohansahoo@gmail.com Community Health System of South Texas, Edinburg, Texas 78539, USA E-mail: bimalbanik10@gmail.com <em>Manuscript received on line 26 September 2018, accepted 01 November 2018</em> Schiff’s bases of 1,2,4-triazole-3-thiol are synthesized by multistep reactions. Schiff bases are the condensation products of primary amines with carbonyl compounds. These compounds possess imine or azomethine (-C=N-) functional group in their structure and

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Devi, Kalpana, and Monica Kachroo. "Synthesis and Docking Studies of Oxazine Derivatives as Anti-inflammatory and Antioxidant Agents." DER PHARMA CHEMICA 13, no. 3 (2021): 9. https://doi.org/10.5281/zenodo.11070994.

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A new series of N-(4-{4-(substituted phenyl)-2-[(4-fluro-benzylidene)-amino]-6H-[1,3] oxazine-6-yl}-phenyl)-isonicotiamide were synthesized by reaction of p-amino acetophenone with isonicotinyl chloride to obtain the secondary amides. ClaisenSchmidth condensation reaction with substituted aldehydes led to the formation of corresponding chalcones. These chalcones were cyclized with urea to form oxazine which further reacted with p-fluorobenzaldehyde to form the corresponding Schiff’s bases. All the synthesized compounds were characterized by IR and 1HNMR spectral data, mass spectra and el

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Devi, Kalpana, and Monica Kachroo. "Synthesis and Docking Studies of Oxazine Derivatives as Anti-inflammatory and Antioxidant Agents." Der Pharma Chemica 13, no. 3 (2021): 9. https://doi.org/10.5281/zenodo.14722735.

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A new series of N-(4-{4-(substituted phenyl)-2-[(4-fluro-benzylidene)-amino]-6H-[1,3] oxazine-6-yl}-phenyl)-isonicotiamide were synthesized by reaction of p-amino acetophenone with isonicotinyl chloride to obtain the secondary amides. ClaisenSchmidth condensation reaction with substituted aldehydes led to the formation of corresponding chalcones. These chalcones were cyclized with urea to form oxazine which further reacted with p-fluorobenzaldehyde to form the corresponding Schiff’s bases. All the synthesized compounds were characterized by IR and 1HNMR spectral data, mass spectra and el

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14

Panda, Krishna Chandra, B. V. V. Ravi Kumar, and Biswa Mohan Sahoo. "Synthesis of Schiff’s Bases of 1,2,4-Triazole Derivatives under Microwave Irradiation Technique and Evaluation of their Anti-diabetic Activity." Current Microwave Chemistry 8, no. 3 (2021): 215–24. http://dx.doi.org/10.2174/2213335608666210930201144.

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Background: Schiff bases play a key role in the generation of a large number of biologically active compounds via cycloaddition, replacement, and ring closure reactions. Objective: The objective of this study is to optimize the purity and yield of the product, improve the reaction time, and make the reaction more eco-friendly with the help of microwave-assisted organic synthesis. Methods: New series of Schiff’s bases of triazole derivatives were achieved via multicomponent reactions. The starting material benzohydrazide 1 was obtained by esterification of benzoyl chloride with methanol in the

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Kaur, Manpreet, and S. Singh. "SYNTHESIS AND ANTICANCER ACTIVITY EVALUATION OF SOME SCHIFF BASES OF 1, 3, 4-OXADIAZOLE." INDIAN DRUGS 56, no. 03 (2019): 12–17. http://dx.doi.org/10.53879/id.56.03.11589.

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A new series of 2,5-disubstituted-1,3,4-oxadiazole derivatives has been synthesized with the help of different aromatic benzaldehydes and final compounds were characterized by FTIR and 1H NMR. 2,5- disubstituted-1,3,4-oxadiazole derivatives were synthesized by the reaction of Schiff base derivatives with 2,5-disubstituted-1,3,4-oxadiazoles. All the synthesized compounds were screened for their anticancer activity. These compounds were evaluated for their anticancer activity against various cancer cell lines. Five of the compounds possessed good to moderate anti-cancer activity. Three of the sy

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Mahdi, Monther F., Noor H. Naser, and Nethal H. Hammud. "SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF NEW NAPROXEN ANALOGUES HAVING 1, 2, 4-TRIAZOLE-3-THIOL." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 7 (2017): 66. http://dx.doi.org/10.22159/ijpps.2017v9i7.18273.

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Objective: The objective of this search was to synthesize a new naproxen analogues having a 1,2,4-triazole-3-thiol heterocyclic ring, and preliminary pharmacological assessment of the anti-inflammatory activity of the synthesized compounds. Methods: The synthesis of naproxen analogues that having 1,2,4-triazole-3-thiol heterocyclic ring occur through esterification of naproxen, and then its reaction with hydrazine hydrate, and carbon disulfide, finally different aromatic aldehydes reacted with triazole derivatives of naproxen containing amino group to produce schiff bases.Results: In vivo acut

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Yabo-Dambagi, Lawali, Ahmet Cakir, Mehmet Akyuz, Aysegul Karakucuk-Iyidogan, and Ali Aslan. "Synthesis of Schiff Bases of Usnic Acid and Investigation of Their Antidiabetic, Antidepressant, Anti-Parkinson’s Disease, Neuroprotective and Antioxidant Potentials." Acta Chimica Slovenica 71, no. 4 (2024): 566–79. https://doi.org/10.17344/acsi.2024.8703.

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Schiff bases have various pharmacological activities due to the azomethine (–C=N–) group. Usnic acid is the most famous lichen metabolite and it contains two carbonyl groups to synthesize the Schiff base derivatives with primary amines. Therefore, in the current study, the known Schiff base derivatives 2–5 of usnic acid (1) were synthesized to explore their antidiabetic, neuroprotective, antioxidant, antidepressant and anti-Parkinson’s disease properties. Among the tested compounds, compound 4 exhibited the strongest antidiabetic and antidepressant activities, inhibiting α-glycosidase, α-amyla

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Sharma, Vaibhav, Dinesh Kumar Mehta, Rina Das, and Preet Kawal Kaur. "SYNTHESIS OF SOME NOVEL TRIAZOLE DERIVATIVES AS SCHIFF BASES AND THEIR ANTIMICROBIAL EVALUATION." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 9 (2016): 28. http://dx.doi.org/10.22159/ijpps.2016.v8i9.11269.

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<p><strong>Objective: </strong>This work involves the synthesis of some novel schiff base derivatives synthesized from <em>p-</em>amino benzoic acid.</p><p><strong>Methods: </strong>A series of 4-[4-(arylidene amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl]-benzoic acid complexes were synthesized from 4-(4-amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl)-benzoic acid by reaction with different aromatic aldehydes. All the synthesized schiff base derivatives were characterized by using analytical techniques (FT-IR, <sup>1</sup>H NMR and Ma

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Kumar, Rohit, Sushil Kumar, and Mohammad Asif Khan. "Synthesis and Pharmacological Evaluation of 2-(4-(3 (Substituted Phenyl) Acryloyl) Phenoxy)-N, N Diphenylacetamides." Journal of Drug Delivery and Therapeutics 10, no. 5 (2020): 274–92. http://dx.doi.org/10.22270/jddt.v10i5.4326.

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Recently a series of Schiff bases of diphenylamine derivatives have been synthesized and evaluated in vitro for their antibacterial activity against pathogenic both Gram-positive bacteria B. subtitles and Gram-negative bacteria E. coli using ciprofloxacin as standard drug at conc. of 50 μg/ml and 100 μg/ml. Literature review revels that chalcones possesses various biological activities like antimicrobial, antiviral, anti-inflammatory, anticancer and sedative etc. Therefore the present study was designed on synthesis and pharmacological evaluation of 2-(4-(3 (Substituted Phenyl) Acryloyl) Pheno

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Gatphoh, Banylla F. D., Natasha N. Aggarwal, Vijaykumar M, and Revanasiddappa B. C. "SYNTHESIS, COMPUTATIONAL AND IN VITRO ANTI-DIABETIC STUDIES OF NOVEL THIAZOLIDIN-4-ONES DERIVATIVES." Indian Drugs 59, no. 03 (2022): 18–24. http://dx.doi.org/10.53879/id.59.03.12584.

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A new series of thiazolidin-4-ones (T1-10) were synthesized by the reaction of Schiff’s bases(Ta-j) and thioglycolic acid in dioxane medium in the presence of anhydrous zinc chloride as a catalyst. All the newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral data and studied for in vitro antidiabetic activity. Most of the synthesized derivatives showed promising antidiabetic activity. This work indicates that the presence of the -OH group attached to the ring may be responsible for the activity. The new compounds were subjected to in silico analysis.

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Raja, Waleed Sajjad*1 Hammad Nasir2 Saba Manzoor3 Muhammad Mueen4 Raja Ahmed5 Syeda Fatima Ashoor6 Ashley Alex Jacob7. "Synthesis, Characterization and In-Silico Studies of Novel Thiazolidine Derivatives and Their Assessment as Potential Anti-Microbial Agents." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 190–203. https://doi.org/10.5281/zenodo.14591380.

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In this study, we report the successful synthesis of four novel Schiff base derivatives (SSB-1 to SSB-4) through condensation reactions between selected aldehydes and primary amines. These Schiff bases served as key intermediates for the subsequent cyclization with cysteine, yielding four thiazolidine derivatives (ST-1 to ST-4). The structural characterization of all synthesized compounds was achieved through advanced spectroscopic techniques, including Nuclear Magnetic Resonance (NMR). The antimicrobial potential of these derivatives was evaluated through in vitro enzyme inhibition assays. Re

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M., Yaswanth, Deepa M., N. Pramod., and B. Somashekar. "In–Silico design, synthesis, characterization and biological evaluation of novel 2-azetidinone derivatives for anti–Leukemic activity." Journal of PeerScientist 2, no. 1 (2020): e1000009. https://doi.org/10.5281/zenodo.3647884.

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Abstract: 2-Azetidinone shows biological activities like anti-bacterial, anti-microbial activity, anti-tubercular activity, and anti-cancer activity. 2-azetdinone derivatives were synthesized by simple procedures. The first step is synthesis of benzohydrazide through nucleophilic substitution reaction between methyl benzoate and hydrazine hydrate. The above formed compound is then treated with substituted aromatic aldehydes in the presence of catalytic amount of concentrated hydrochloric acid with stirring for one hour to give benzohydrazone which results in the formation of Schiff bases.Schif

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23

Almehmadi, Mazen, Mamdouh Allahyani, Ayman Al-hazmi, and Mohammad Asif. "Synthesis and in vitro anti-bacterial evaluation of some 3-((4-(4-(arylideneamino)-5-mercapto-4H-1,2,4- triazol-3-yl)phenyl)imino)isoindolin-1-one derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 135. https://doi.org/10.59467/ijhc.2025.35.135.

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Some 3-((4-(4-(arylideneamino)-5-mercapto-4H-1,2,4-triazol-3-yl)phenyl)imino)isoindolin-1-one derivatives (3a-e) were synthesized by the reaction of 3-((4-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)phenyl)imino)indolin-2-one (2) with aryl aldehydes. The in vitro anti-bacterial activity of the synthesized compounds was tested against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. Some compounds (3a-c) exhibited satisfactory antibacterial efficacy against tested bacteria. The most effective compound against tested bacteria was compound 3a.. KEYWORDS :Indoledi

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Senthil Kumar, Raju, Sundhararajan Naveena, Sekar Praveen, and Nagalingam Yogadharshini. "Therapeutic aspects of biologically potent vanillin derivatives: A critical review." Journal of Drug Delivery and Therapeutics 13, no. 7 (2023): 177–89. http://dx.doi.org/10.22270/jddt.v13i7.6159.

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4-hydroxy 3-methoxy benzaldehyde (Vanillin) is an aromatic phenolic aldehyde with unique chemical properties and pharmacological impact. Because of its potent nature, it acts as a lead for drug discovery and development techniques. Heterocyclic compounds with vanillin moiety were efficacious and thrive against many emerging infectious diseases, which can also lead to develop numerous fused heterocyclic vanillin derivatives and various heterocyclic compounds such as pyrimidines, quinoxalines, imidazoles or thiazoles. Greener-mediated synthesis is a sustained chemical reaction used to synthesize

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Hegab, Mohamed I., Nasser A. Hassan, and Farouk M. E. Abdel-Megeid. "Three-component Reaction of Cycloheptanone, 6-Amino-1,3-Dimethyluracil and Aromatic Aldehydes; X-Ray Structure, and Anti-inflammatory Evaluation of the Products." Zeitschrift für Naturforschung B 63, no. 9 (2008): 1117–26. http://dx.doi.org/10.1515/znb-2008-0917.

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1,3-Dimethyl-5-aryl-1,6,7,8,9,10-hexahydrocyclohepta[5,6]pyrido[2,3-d]pyrimidine-2,4-diones 4a, b (the linear regioisomers) and the Schiff bases, 6-N-benzylidenamino-1,3-dimethyluracil derivatives 5a, b, were isolated from a three-component reaction of cycloheptanone, 6-amino-1,3- dimethyluracil, and 4-chloro- or 4-bromobenzaldehyde. Surprisingly, 1,3-dimethyl-10-aryl-1,5,6,7, 8,9-hexahydrocyclohepta[4,5]pyrido-[2,3-d]pyrimidine-2,4-diones 6f, g (the angular regioisomers which are described for the first time in the literature under the given reaction conditions) and the Schiff bases, 6-N-benz

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Nimbalkar, Urja, Julio Seijas, Rachna Borkute, et al. "Ultrasound Assisted Synthesis of 4-(Benzyloxy)-N-(3-chloro-2-(substitutedphenyl)-4-oxoazetidin-1-yl) Benzamide as Challenging Anti-Tubercular Scaffold." Molecules 23, no. 8 (2018): 1945. http://dx.doi.org/10.3390/molecules23081945.

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A series of ten novel derivatives of 4-(benzyloxy)-N-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl) benzamide 6a–j were synthesized in good yield from the key compound 4-(benzyloxy)-N′-(substituted benzylidene) benzo hydrazide, called Schiff ’s bases 5a–j, by Staudinger reaction ([2 + 2] ketene-imine cycloaddition reaction) with chloro acetyl chloride in the presence of catalyst tri ethylamine and solvent dimethyl formamide (DMF), by using ultra-sonication as one of the green chemistry tools. All the synthesised compounds were evaluated for in vitro anti-tubercular activity against Mycob

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Shaikh, Muniza, Salman Siddiqui, Humaira Zafar, et al. "Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In Vitro and In Silico Study." Medicinal Chemistry 16, no. 4 (2020): 575–91. http://dx.doi.org/10.2174/1573406415666190212105718.

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Background: Advanced glycation end products (AGEs) are known to be involved in the pathophysiology of diabetic complications, neurodegenerative diseases, and aging. Preventing the formation of AGEs can be helpful in the management of these diseases. Objective: Two classes of previously synthesized traizole Schiff’s bases (4H-1,2,4-triazole-4- Schiff’s bases 1-14, and 4H-1,2,4-triazole-3-Schiff’s bases 15-23) were evaluated for their in vitro antiglycation activity. Methods: In vitro fructose-mediated human serum albumin (HSA) glycation assay was employed to assess the antiglycation activity of

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K.K., Sivakumar, Rajalakshmi G, and Rajasekaran A. "Synthesis, characterization and biological evaluation of Schiff bases of 5-amino-4-[2-(4-nitro-1,3-benzothiazol-2 yl)hydrazinylidene]-2,4-dihydro- 3H-pyrazol-3-one derivatives." International Journal of Drug Design and Discovery 3, no. 4 (2025): 886–97. https://doi.org/10.37285/ijddd.3.4.2.

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In the present work totally 12 Schiff bases of 5-amino-4-[2-(4-nitro-1,3-benzothiazol-2 yl)hydrazinylidene]-2,4-dihydro- 3H-pyrazol-3-one were synthesized. Synthesized compounds were characterized on the basis of physicochemical as well as spectral data (UV, IR, 1HNMR and mass spectra) and evaluated for in vitro anti-microbial, anti-tubercular and cytotoxic activity. All the synthesized compounds (100 Âµg/disc) showed mild to moderate activity against Gram-positive bacteria, more potent or equal activity against Gram-negative bacteria and moderate to significant anti-fungal activity compared w

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Teran, Guevara, Mora, et al. "Characterization of Antimicrobial, Antioxidant, and Leishmanicidal Activities of Schiff Base Derivatives of 4-Aminoantipyrine." Molecules 24, no. 15 (2019): 2696. http://dx.doi.org/10.3390/molecules24152696.

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Our main interest is the characterization of compounds to support the development of alternatives to currently marketed drugs that are losing effectiveness due to the development of resistance. Schiff bases are promising biologically interesting compounds having a wide range of pharmaceutical properties, including anti-inflammatory, antipyretic, and antimicrobial activities, among others. In this work, we have synthesized 12 Schiff base derivatives of 4-aminoantipyrine. In vitro antimicrobial, antioxidant, and cytotoxicity properties are analyzed, as well as in silico predictive adsorption, di

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U, Usha Rani, and Sreedevi A. "Synthesis and Biological Evaluation of 3-(2-Benzoyl-4-chlorophenyl)-4H-spiro [indole-3,2-[1,3]thiazolidine]-2,4(1H)- dione Derivatives for Anti-tubercular and Antimicrobial Activities." Indian Journal of Science and Technology 17, no. 20 (2024): 2101–9. https://doi.org/10.17485/IJST/v17i20.1434.

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Abstract <strong>Objectives:</strong> To synthesize a new scaff fold of 3'-(2-Benzoyl-4-chlorophenyl)-4'H-spiro [indole-3,2'-[1,3] thiazolidine]-2,4'(1H)-dione derivatives and to assess the compounds for anti-tubercular and antimicrobial activities. <strong>Methods :</strong> A new series of 3'-(2-Benzoyl-4-chlorophenyl)-4'H-spiro [indole-3,2'- [1,3] thiazolidine]-2,4'(1H)-dione derivatives were prepared by synthesizing schiff’s bases followed by condensing schiff base with 2-mercaptopropanoic acid in the presence of zinc chloride. Synthesized compounds were characterized

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Chavan, Rakesh R., and Kallappa M. Hosamani. "Microwave-assisted synthesis, computational studies and antibacterial/ anti-inflammatory activities of compounds based on coumarin-pyrazole hybrid." Royal Society Open Science 5, no. 5 (2018): 172435. http://dx.doi.org/10.1098/rsos.172435.

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An efficient, high-yield and rapid synthesis of (E)-1,5-dimethyl-4-((2-((substituted-2-oxo-2H-chromen-4-yl)methoxy)naphthalen-1-yl)methyleneamino)-2-phenyl-1,2-dihydropyrazol-3-one derivatives (3a–3i) containing Schiff base structures under microwave-irradiation has been described. Schiff base is a potential target to discover anti-inflammatory chemotherapeutics, material science, catalysis and molecular magnetism. All the newly synthesized compounds (3a–3i) have been characterized by elemental analysis and spectroscopic techniques. The synthesized compounds (3a–3i) were evaluated for their an

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Amr, Abd El-Galil E., Randa E. Abdel Mageid, Mohamed El-Naggar, Ahmed M. Naglah, Eman S. Nossier, and Elsayed A. Elsayed. "Chiral Pyridine-3,5-bis- (L-phenylalaninyl-L-leucinyl) Schiff Base Peptides as Potential Anticancer Agents: Design, Synthesis, and Molecular Docking Studies Targeting Lactate Dehydrogenase-A." Molecules 25, no. 5 (2020): 1096. http://dx.doi.org/10.3390/molecules25051096.

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A series of branched tetrapeptide Schiff bases 3–6 were designed and synthesized from corresponding tetrapeptide hydrazide 2 as a starting material.In vitroevaluation of the synthesized compounds 4–6 against breast MCF-7 carcinoma cells identified their excellent anticancer potency, with IC50 ranging from 8.12 ± 0.14 to 17.55 ± 0.27 μM in comparison with the references, cisplatin and milaplatin (IC50= 13.34 ± 0.11and 18.43 ± 0.13 μM, respectively). Furthermore, all derivatives demonstrated promising activity upon evaluation of theirin vitroandin vivosuppression of p53 ubiquitination and inhibi

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Saini, Pooja, Sushil Kumar, and Swatantr Bahadur Singh. "Molecular Docking, Synthesis and In vivo Assessment of New Phenothiazines as Inhibitors of Anxiety." Biosciences Biotechnology Research Asia 21, no. 4 (2024): 1485–93. https://doi.org/10.13005/bbra/3319.

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ABSTRACT: Background: Heterocylics are the backbone of the medicinal chemistry. They played very imperative role in the discovery of new lead molecules. Phenothiazine is one of them and it has many biological activities as well. This article proposed the design and synthesis of new phenothiazine derivatives. Aim: This work includes the preparation of some new Schiff bases of phenothiazine. The synthetic scheme includes development of series of 1-(10H-phenothiazin-10-yl)-2-(4-((phenylimino)methyl) phenoxy) ethan-1-one (D1-D10). Objective: This work aims to design some new phenothiazine molecule

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Saravanan, Govindaraj, Theivendren Selvam, Veerachamy Alagarsamy, et al. "Graph Theoretical Analysis, In Silico Modeling, Synthesis, Anti-Microbial and Anti-TB Evaluation of Novel Quinoxaline Derivatives." Drug Research 68, no. 05 (2017): 250–62. http://dx.doi.org/10.1055/s-0043-120198.

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Abstract Background We designed to synthesize a number of 2-(2-(substituted benzylidene) hydrazinyl)-N-(4-((3-(phenyl imino)-3,4-dihydro quinoxalin-2(1 H)-ylidene)amino) phenyl) acetamide S1-S13 with the hope to obtain more active and less toxic anti-microbial and anti-TB agents. Methods A series of novel quinoxaline Schiff bases S1-S13 were synthesized from o-phenylenediamine and oxalic acid by a multistep synthesis. In present work, we are introducing graph theoretical analysis to identify drug target. In the connection of graph theoretical analysis, we utilised KEGG database and Cytoscape s

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Hala Ayad Mohamed Rasheed and Suaad M. H. Al-Majidi. "Synthesis, Molecular Docking Study, Anti-Oxidant and Cytotoxicity Evaluation of New Spiro Six Membered Ring Derivatives of 5-nitro isatin." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 33, no. 2 (2024): 36–48. http://dx.doi.org/10.31351/vol33iss2pp36-48.

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Spiro-5-nitro isatino six memberd ring (quinazoline-4-one, thiazine-4-one and oxazine-4-one) respectively were produced by a cycloaddition of 5-nitro isatin Schiff bases [1–5] with anthranilic acid, o-mercapto benzoic acid and salicylic acid. 1HNMR and 13CNMR nuclear magnetic resonance spectroscopies, as well as Fourier-transform infrared spectroscopy, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin are of interest to us due to their potential antioxidant and anticancer properties. The MTT assay ((3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium B

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Abd Elhady, Hebe, Hossa AL-SHAREEF, Khadeega Takroni, and Wedad Alharbi. "One-Pot Synthesis of New Bipyridine and Yerpyridine Derivatives: Anti-proliferative Evaluation, DNA Flow Cytometry Analysis, and Molecular Docking Study." Acta Poloniae Pharmaceutica - Drug Research 81, no. 3 (2024): 423–37. http://dx.doi.org/10.32383/appdr/191341.

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Some new bipyridine derivatives were synthesized using 2-oxo-4-(pyridin-3-yl)-6-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile 1a. While terpyridine derivatives were synthesized using 2-oxo-4-(pyridin-3-yl)-6-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile 1b as starting material. Alkylation of compounds 1a, b gave the alkyl derivatives 2a, b which converted into aceto hydrazides 3a,b. Treating the aceto hydrazides with ethyl cyanoacetate afforded 2'-(2-(3,5-dioxopyrazolidin-1-yl)-2-oxoethoxy)-6'-(thiophen-2-yl)-3,4'-bipyridine-3'-carbonitrile 4a and 6'-[2-(3,5-dioxopyrazolidin-1-yl)-2-o

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Lewicka, Kamila, Anna Smola-Dmochowska, Piotr Dobrzyński, et al. "Microspheres Based on Blends of Chitosan Derivatives with Carrageenan as Vitamin Carriers in Cosmeceuticals." Polymers 16, no. 13 (2024): 1815. http://dx.doi.org/10.3390/polym16131815.

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Chitosan (CS) has a natural origin and is a biodegradable and biocompatible polymer with many skin-beneficial properties successfully used in the cosmetics and pharmaceutical industry. CS derivatives, especially those synthesized via a Schiff base reaction, are very important due to their unique antimicrobial activity. This study demonstrates research results on the use of hydrogel microspheres made of [chitosan-graft-poly(ε-caprolactone)]-blend-(ĸ-carrageenan)], [chitosan-2-pyridinecarboxaldehyde-graft-poly(ε-caprolactone)]-blend-(ĸ-carrageenan), and chitosan-sodium-4-formylbenzene-1,3-disulf

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Ruwaidah S.Saeed, Widad Abed Shlaka, and El-Sayed Negim. "Synthesis and Study Medical Application of Nanocomposites Based on grafted Chitosan /Polyvinyl alcohol." Ibn AL-Haitham Journal For Pure and Applied Sciences 37, no. 1 (2024): 236–50. http://dx.doi.org/10.30526/37.1.3327.

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In the present study, synthesis of bis Schiff base [I, II] by reaction of one mole of terephthalaldehyde with two mole of 2-amino-5-mercapto-1,3,4-thiadiazole or 4-amino benzene thiol in the ethanol absolute, then compounds [I,II] were reacted with Na2CO3 of distilled H2O, then chloroacetic acid was added to yield compounds [III,IV]. O-chitosan derivatives [V,VI] were synthesized by reaction of chitosan with compounds [III,IV] in acidic media in distilled water according to the steps of Fischer. O–chitosan (grafted chitosan) [V,VI] was blended with synthetic polymer polyvinyl alcohol (PVA) to

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Abu-Hashem, Ameen Ali, and Sami A. Al-Hussain. "Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Novel Thiazoles, Pyrazoles, 1,3-Thiazepinones, and 1,2,4-Triazolopyrimidines Derived from Quinoline-Pyrido[2,3-d] Pyrimidinones." Pharmaceuticals 17, no. 12 (2024): 1632. https://doi.org/10.3390/ph17121632.

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Background: Recently, pyrido[2,3-d] pyrimidine, triazolopyrimidine, thiazolopyrimidine, quinoline, and pyrazole derivatives have gained attention due to their diverse biological activities, including antimicrobial, antioxidant, antitubercular, antitumor, anti-inflammatory, and antiviral effects. Objective: The synthesis of new heterocyclic compounds including 5-quinoline-pyrido[2,3-d] pyrimidinone (1–2, 4, 6–7), 6-quinoline-pyrido[2,3-d]thiazolo[3,2-a]pyrimidinone (3, 5, 8–10), 1,2,4-triazole-6-quinoline-pyrido[2,3-d]thiazolo[3,2-a]pyrimidinone (11–13), and pyrido[2,3-d]thiazolo[3,2-a]pyrimidi

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Swapna, Kandagatla, M. Srujana, and Mamidala Estari. "Identification of terpenoids from Withania somnifera as a HIV-1 entry inhibitors that prevent gp120 binding to CD4 using In Silico Approach." High Technology Letters 28, no. 12 (2022): 973–81. https://doi.org/10.5281/zenodo.7479434.

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<strong>Introduction</strong> Human immunodeficiency virus (HIV-1), the most prevalent and pathogenic type of the virus, is what causes acquired immunodeficiency syndrome (AIDS). Approximately 30 anti-HIV-1 medications have been applied to the management of AIDS. However, effective anti HIV-1 agents with less side affect and high inhibition potency are still in demand. The objective of this study was to identify the potential terpenoid compounds from <em>Withania somnifera</em> plant that might be active as anti-HIV-1 gp120 by molecular docking that inhibits viral attachment and entry for the

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C.D., Patil, and Bhandare P.S. "SYNTHESIS AND ANTICONVULSANT ACTIVITY OF 4-THIAZOLIDINONE ANALOGUES OF 2-AMINO-5-CHLOROPYRIDINE." July 20, 2023. https://doi.org/10.5281/zenodo.8223809.

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The synthesis of 4-thiazolidinones of 2-amino-5-chloropyridine was performed by novel method of stirring involving the cyclocondensation of the appropriate Schiffs bases (2aâ€“c) with thioglycolic acid, followed by the addition of zinc chloride in the presence of molecular sieves. Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques- Solubility,Thin Layer Chromatographic studies, Ultra-Violet studies,Rotational and vibrational studies (FT-IR),<sup> 1</sup>H-NMR stu

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D B Joshi. "TO SYNTHESIZE, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NOVEL SUBSTITUTED ISATIN DERIVATIVES." Journal of Biomedical and Pharmaceutical Research 9, no. 1 (2020). http://dx.doi.org/10.32553/jbpr.v9i1.719.

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Series of novel Schiff bases of Isatin the equimolar amines and 5-Dicrboxymethyl (R=COO2Me) substituted isatins (1 mmol of each) were added to 96% w/w ethanol (20 mL) containing 8 drops of glacial acetic acid. The mixture was heated under reflux for 5 h and then cooled to room temperature. The resulting solid was collected by filtration, washed with cold ethanol and dried in open air. The derivatives thus prepared had sufficient analytical purity. anticonvulsant activity performed by method as Animals were weighed and numbered. Mice were divided into 7 groups of six animals each. Group 1 serve

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Khan, Momin, Zala Fazal, Aftab Alam, et al. "Synthetic Transformation of 4-fluorobenzoic acid to 4-fluorobenzohydrazide Schiff Bases and 1,3,4-Oxadiazole Analogs having DPPH Radical Scavenging Potential." Letters in Drug Design & Discovery 20 (October 31, 2022). http://dx.doi.org/10.2174/1570180820666221031091246.

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Aims: Synthesis of 4-fluorobenzohydrazide Schiff bases and 1,3,4-oxadiazole analogs has DPPH radical scavenging potential. Background: Synthetic antioxidants are widely used because they are effective and cheaper than natural antioxidants. On the basis of the literature survey, this present study is mainly focused on the study of free radical scavenging activity of the Schiff base and oxadiazole motifs. Method: In this research work, Schiff’s base (4a-4g) and 1,3,4-oxadiazole (5a-5g) derivatives based on 4-fluorobenzoic acid were synthesized through multistep reactions. Initially, 4-fluorobenz

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C., Mallikarjunaswamy*1 V. Lakshmi Ranganatha2 L. Mallesha1 D.G. Bhadregowda3. "NOVEL PYRIMIDINE SCHIFF BASES: SYNTHESIS AND PHARMACOLOGICAL SCREENING." January 31, 2017. https://doi.org/10.5281/zenodo.2349184.

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Schiff bases are aldehydelike compounds in which an imine group replaces the carbonyl group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This study represents the synthesis of a new series of (E) -N-benzylidene-5-bromo-2-chloropyrimidin-4-amine derivatives (6a-l). The newly synthesized compounds were characterized by different spectral studies. All these new compounds screened for their anti-inflammatory, antimicrobial and in vitro antioxidant activities. Structure–activity relationship analysis demonstrates that hydroxyl groups o

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Alka., T* Bhavesh. Y. Prakash. C. Ankush. S. Smita. T. "SYNTHESIS AND ANTI-BACTERIAL ACTIVITY OF SYNTHESIZED SCHIFFBASE USING 2,3-DICHLOROANILINE AND CARBONYL COMPOUND." June 1, 2023. https://doi.org/10.5281/zenodo.7993050.

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Drug resistance is a serious and expanding threat to global public health, and it will take continuous and coordinated efforts to develop the novel range of antibiotics to battle against infectious diseases to address this problem. Many studies shown that the aniline and carbonyl compound derivatives have numerous biological and anti-bacterial activity. The purpose of this study was to create 2,3-Dichloroaniline derivatives and characterization of synthesized Schiff bases.1-H NMR and IR spectroscopic studies were used to assess the chemical structure of synthesized Schiff base. Also, it was de

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Panaskar, Amit N., Ashish Jain, and Pradeep Kumar Mohanty. "Molecular Docking Study of 3, 4- Dihydropyrimidone Derivatives as Novel Anti-inflammatory Agents." Journal of Pharmaceutical Research International, September 15, 2021, 481–87. http://dx.doi.org/10.9734/jpri/2021/v33i43b32578.

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Aim: Currently, researchers have developed a lot of new active substances as anti-inflammatory agents. One of the target proteins for anti-inflammatory agents is the selective COX-2 active site. Selective COX-2 inhibition is the regulator of the inflammatory reaction cascade. In this research, 3, 4- Dihydropyrimidone derivatives were used to design the anti-inflammatory agent through a selective COX-2 inhibition. The potential activity of 3, 4- Dihydropyrimidone derivatives maybe increase due to the preparation of the Schiff base with aromatic aldehydes. Selective COX-2 inhibition was required

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Ojha, Smriti, Preeti Verma, Sushil Kumar, and Sudhanshu Mishra. "Synthesis characterization and biological activity of 4-methyl-benzene sulfonohydrazide derivatives." Letters in Drug Design & Discovery 20 (October 24, 2022). http://dx.doi.org/10.2174/1570180820666221024141247.

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Background: A Schiff base is generally bi- or tri-dentate ligands capable of forming very stable complexes with transition metals. Schiff base complexes have synthetic flexibilities and biological activity against various diseases. Objective: In the current study, Schiff bases compounds [PV1 – PV5] were synthesized from 4-methyl-1-benzene sulfonyl chloride. Subsequently, the synthesized products were analyzed for their antibacterial activity. Methods: Schiff base is a nitrogen analog with a carbonyl group. The reaction that results in the formation of new complexes involves the condensation of

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Rabbia Mushtaq, Muhammad Rashid, Saliha Abrar, et al. "PHARMACOLOGICAL EVALUATION OF SYNTHETIC DERIVATIVES OF HALOGENATED SCHIFF BASE FOR ITS ANTIMICROBIAL, ANTIOXIDANT, AND ANTI-INFLAMMATORY ACTIVITIES." International Journal of Pharmacy & Integrated Health Sciences 6, no. 1 (2025). https://doi.org/10.56536/ijpihs.v6i1.229.

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Background: Microbial drug resistance is an emerging worldwide issue affecting developed and developing countries. In order to counter this challenge, scientists are working to synthesize new molecules that are safe and effective and specifically tailored to target resistant microorganisms. Halogenated Schiff bases, in particular, have demonstrated significant antimicrobial activity against various bacterial and fungal strains, along with anti-inflammatory and antioxidant properties. Objectives: The main objective of study was to investigate the anti-bacterial and anti-fungal effect of new syn

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Gupta, Sakshi, Nalini Kanta Sahoo, Komalpreet Kaur, Jahanvi Gupta, Anita Singh, and Amrita Verma Pargaien. "Docking Investigations Targeting Receptors 2AZ5 and 5KIR, along with the Synthesis and Pharmacological Assessment of Derivatives of 7-Hydroxy-4-Methyl Coumarin." Current Bioactive Compounds 21 (December 17, 2024). https://doi.org/10.2174/0115734072353938241127112120.

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Background: Inflammation, a crucial defense mechanism of the immune system, seeks to safeguard and restore tissue equilibrium in response to tissue damage or infection by pathogens. Key indicators of inflammation include redness, discomfort, swelling, warmth, and impaired function. However, unmanaged inflammation can lead to serious health issues. Objective: The aim of this research work is to perform docking studies to find out the potent antiinflammatory activity of various moieties (Schiff bases, hydrazones, and amino acid) derivatives, which are attached to C-8 of 7-hydroxy-4-methyl coumar

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Baqi Aldujaili, Radhiyah Abdul, Rasha Nazik Talib, and Ahmed Ali younus Alhasan. "The Spectral Study and Biological Activity for Azo-Shiff Bases Derivatives containing Pyrimidine Ring." Research Journal of Pharmacy and Technology, March 31, 2023, 1289–95. http://dx.doi.org/10.52711/0974-360x.2023.00212.

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The importance of Schiff's bases is that they are used as anti-bacterial, tuberculosis, cancer and tumors, as well as their ability to capture metal ions. Schiff's bases play an important role in analytical and industrial chemistry as they are used to resist the corrosion of metals. Photolysis is not considered a degradation pathway for azo dyes. In order to extend the life of products dyed with azo dyes, it is necessary to ensure stability against microbial attack, and tests have shown that azo dyes degrade significantly in short-term tests under aerobic conditions. However, under anaerobic c

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