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1

Chmielewski, Nicole N., and Charles L. Limoli. "Sex Differences in Taxane Toxicities." Cancers 14, no. 14 (2022): 3325. http://dx.doi.org/10.3390/cancers14143325.

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The taxane family of microtubule poisons and chemotherapeutics have been studied for over 50 years and are among the most frequently used antineoplastic agents today. Still, limited research exists characterizing taxane-induced sex-specific mechanisms of action and toxicities in cancer and non-cancerous tissue. Such research is important to advance cancer treatment outcomes as well as to address clinically observed sex-differences in short- and long-term taxane-induced toxicities that have disproportionate effects on female and male cancer patients. To gain more insight into these underlying d
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Leung M.D., Dr Alice, and Dr Pierre Chue M. R. C. Psych. "Sex differences in schizophrenia, a review of the literature." Acta Psychiatrica Scandinavica 101, no. 401 (2000): 3–38. http://dx.doi.org/10.1111/j.0065-1591.2000.0ap25.x.

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Mahović, Darija, and Matea Bračić. "Cluster Headache: Literature Review with Reference to Sex Differences." Archives of Psychiatry Research 59, no. 1 (2023): 75–86. http://dx.doi.org/10.20471/may.2023.59.01.10.

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Cluster headache is a pain syndrome characterised by severe, unilateral and predominantly orbital pain which lasts 15 - 180 minutes. It is accompanied by a range of ipsilateral autonomic symptoms, such as lacrimation, rhinorrhoea and myosis. Cluster headaches can be episodic with periods of remission or chronic. Even though it is a relatively rare condition, the excruciating pain causes significant disruption of patients’ daily life. The pathophysiology behind cluster headaches is complex and despite making significant progress, the pathogenetic cascade of events hasn’t been entirely elucidate
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Walter, Kathryn V., Daniel Conroy-Beam, David M. Buss, et al. "Sex differences in human mate preferences vary across sex ratios." Proceedings of the Royal Society B: Biological Sciences 288, no. 1955 (2021): 20211115. http://dx.doi.org/10.1098/rspb.2021.1115.

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A wide range of literature connects sex ratio and mating behaviours in non-human animals. However, research examining sex ratio and human mating is limited in scope. Prior work has examined the relationship between sex ratio and desire for short-term, uncommitted mating as well as outcomes such as marriage and divorce rates. Less empirical attention has been directed towards the relationship between sex ratio and mate preferences, despite the importance of mate preferences in the human mating literature. To address this gap, we examined sex ratio's relationship to the variation in preferences
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Aiken, Catherine E., and Susan E. Ozanne. "Sex differences in developmental programming models." REPRODUCTION 145, no. 1 (2013): R1—R13. http://dx.doi.org/10.1530/rep-11-0489.

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The theory of developmental programming suggests that diseases such as the metabolic syndrome may be ‘programmed’ by exposure to adverse stimuli during early development. The developmental programming literature encompasses the study of a wide range of suboptimal intrauterine environments in a variety of species and correlates these with diverse phenotypic outcomes in the offspring. At a molecular level, a large number of variables have been measured and suggested as the basis of the programmed phenotype. The range of both dependent and independent variables studied often makes the development
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Brodovskaya, T. O., and D. V. Kasyanov. "Sex-specific differences in hypertension." Russian Journal of Cardiology 28, no. 12 (2023): 5646. http://dx.doi.org/10.15829/1560-4071-2023-5646.

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The diagnosis of hypertension (HTN) has been known to doctors for many years. Current clinical guidelines represent a unified approach to the treatment and prevention of hypertension in patients of both sexes. Meanwhile, there are data that the development, course, progression and treatment of the disease may differ depending on sex.The aim of the review was to systematize modern ideas about sex differences in hypertension, as well as to substantiate the differentiated treatment among men and women. A literature search for 2013-2023 was conducted in the PubMed, Cochrane Library, Embase, Google
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Wilder, Gita Z., and Kristin Powell. "SEX DIFFERENCES IN TEST PERFORMANCE: A SURVEY OF THE LITERATURE." ETS Research Report Series 1989, no. 1 (1989): i—50. http://dx.doi.org/10.1002/j.2330-8516.1989.tb00330.x.

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8

Moores, Ginette, Elena Wolff, Aleksandra Pikula, and Esther Bui. "Sex differences in neurology: a scoping review protocol." BMJ Open 12, no. 4 (2022): e054513. http://dx.doi.org/10.1136/bmjopen-2021-054513.

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IntroductionSex and gender are independently important in health and disease but have been incompletely explored in neurology. This is in part contributed to by the pre-existing male bias in scientific literature that results in fewer females being included in clinical research and the often interchangeable use of sex and gender in the literature. This scoping review intends to identify the advances as well as under-explored aspects of this field to provide a road map for future research. This paper outlines the methods for a scoping review of published, peer-reviewed literature on sex and gen
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9

Moores, Ginette, Patrick E. Steadman, Amirah Momen, Elena Wolff, Aleksandra Pikula, and Esther Bui. "Sex differences in neurology: a scoping review." BMJ Open 13, no. 4 (2023): e071200. http://dx.doi.org/10.1136/bmjopen-2022-071200.

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ObjectiveHistorically, neurology research has demonstrated a sex bias with mainly male subjects included in clinical trials as well as lack of reporting of data by sex. In recent years, emphasis has been placed on increased participation of female participants and explicit declaration/evaluation of sex differences in clinical research.We aimed to review the available literature examining sex differences across four subspecialty areas in neurology (demyelination, headache, stroke, epilepsy) and whether sex and gender terms have been used appropriately.DesignThis scoping review was performed by
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10

Ositkovska, Oleksandra, and Oхana Bayer. "Sex Differences in Attention-Deficit/Hyperactivity Disorder (ADHD): Short Literature Review." Bulletin of Taras Shevchenko National University of Kyiv. Series “Psychology”, no. 2 (12) (2020): 72–76. http://dx.doi.org/10.17721/bsp.2020.2(12).13.

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The review of the latest foreign literature on the issue of sex differences in ADHD carriers is presented. The analysis of theories on the causes of the prevalence of the disorder among boys and girls is presented, and minor sex differences are highlighted. Therefore, ADHD is more common among boys than among girls, which leads to arguments about the difference valid in the prevalence of the disorder among men and women. Also, many researchers have noticed certain differences in the symptoms and behaviour of girls compared to boys, both in childhood and adulthood. Boys and girls with ADHD appe
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11

Keller, Kathleen, Samantha Kling, Bari Fuchs, et al. "A Biopsychosocial Model of Sex Differences in Children’s Eating Behaviors." Nutrients 11, no. 3 (2019): 682. http://dx.doi.org/10.3390/nu11030682.

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The prevalence of obesity and eating disorders varies by sex, but the extent to which sex influences eating behaviors, especially in childhood, has received less attention. The purpose of this paper is to critically discuss the literature on sex differences in eating behavior in children and present new findings supporting the role of sex in child appetitive traits and neural responses to food cues. In children, the literature shows sex differences in food acceptance, food intake, appetitive traits, eating-related compensation, and eating speed. New analyses demonstrate that sex interacts with
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12

Leeds, Rebecca, Ari Shechter, Carmela Alcantara, et al. "Elucidating the Relationship Between Insomnia, Sex, and Cardiovascular Disease." Gender and the Genome 4 (January 1, 2020): 247028972098001. http://dx.doi.org/10.1177/2470289720980018.

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Sex differences in cardiovascular disease (CVD) mortality have been attributed to differences in pathophysiology between men and women and to disparities in CVD management that disproportionately affect women compared to men. Similarly, there has been investigation of differences in the prevalence and presentation of insomnia attributable to sex. Few studies have examined how sex and insomnia interact to influence CVD outcomes, however. In this review, we summarize the literature on sex-specific differences in the prevalence and presentation of insomnia as well as existing research regarding t
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Alam, Fatima, and Patricia Silveyra. "Sex Differences in E-Cigarette Use and Related Health Effects." International Journal of Environmental Research and Public Health 20, no. 22 (2023): 7079. http://dx.doi.org/10.3390/ijerph20227079.

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Background: Electronic cigarettes (e-cigarettes) comprise a variety of products designed to deliver nicotine, flavorings, and other substances. To date, multiple epidemiological and experimental studies have reported a variety of health issues associated with their use, including respiratory toxicity, exacerbation of respiratory conditions, and behavioral and physiological effects. While some of these effects appear to be sex- and/or gender-related, only a portion of the research has been conducted considering these variables. In this review, we sought to summarize the available literature on
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14

Garcia, Patricia A., and John S. Geisler. "Sex and Age/Grade Differences in Adolescents' Self-Disclosure." Perceptual and Motor Skills 67, no. 2 (1988): 427–32. http://dx.doi.org/10.2466/pms.1988.67.2.427.

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Few significant differences in self-disclosure were noted for 202 adolescents in Grades 8 and 12. Reliability and validity were reasonable but varied over 6 categories of disclosure. Both boys and girls disclosed more to target females and less to fathers. Findings agree with prior literature.
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15

Smyk, Daniel S., Eirini I. Rigopoulou, Albert Pares, et al. "Sex Differences Associated with Primary Biliary Cirrhosis." Clinical and Developmental Immunology 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/610504.

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Primary biliary cirrhosis (PBC) is a cholestatic liver disease of autoimmune origin, characterised by the destruction of small intrahepatic bile ducts. The disease has an unpredictable clinical course but may progress to fibrosis and cirrhosis. The diagnostic hallmark of PBC is the presence of disease-specific antimitochondrial antibodies (AMA), which are pathognomonic for the development of PBC. The disease overwhelmingly affects females, with some cases of male PBC being reported. The reasons underlying the low incidence of males with PBC are largely unknown. Epidemiological studies estimate
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16

Mogil, Jeffrey S. "Qualitative sex differences in pain processing: emerging evidence of a biased literature." Nature Reviews Neuroscience 21, no. 7 (2020): 353–65. http://dx.doi.org/10.1038/s41583-020-0310-6.

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17

Zagni, Emanuela, Lucia Simoni, and Delia Colombo. "Sex and Gender Differences in Central Nervous System-Related Disorders." Neuroscience Journal 2016 (May 30, 2016): 1–13. http://dx.doi.org/10.1155/2016/2827090.

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There are important sex differences in the brain that seem to arise from biology as well as psychosocial influences. Sex differences in several aspects of human behavior and cognition have been reported. Gonadal sex steroids or genes found on sex chromosomes influence sex differences in neuroanatomy, neurochemistry and neuronal structure, and connectivity. There has been some resistance to accept that sex differences in the human brain exist and have biological relevance; however, a few years ago, it has been recommended by the USA National Institute of Mental Health to incorporate sex as a va
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18

Hubbard, Ruth. "Constructing Sex Difference." New Literary History 19, no. 1 (1987): 129. http://dx.doi.org/10.2307/469305.

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19

Bilbo, Staci D. "Sex Differences Shape Brain Development and Function, in Health and Disease: Policy Implications." Policy Insights from the Behavioral and Brain Sciences 5, no. 1 (2017): 104–9. http://dx.doi.org/10.1177/2372732217742673.

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Sex differences profoundly impact health and disease. Despite this, the inclusion of females in clinical and fundamental research lags far behind advances in other aspects of medicine, especially in the brain sciences. Regardless of whether neuroscientists are intrinsically interested in sex differences per se, observing a sex disparity in the incidence or presentation of a given neurological disorder provides a significant clue into the neurobiology of that disorder. Autism spectrum disorder (ASD) is one of the most sex-biased disorders, with a 4:1 male-to-female ratio, an important aspect of
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20

Crislip, G. Ryan, and Jennifer C. Sullivan. "T-cell involvement in sex differences in blood pressure control." Clinical Science 130, no. 10 (2016): 773–83. http://dx.doi.org/10.1042/cs20150620.

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Hypertension affects one-third of adults in the Western world and is the most common independent risk factor for cardiovascular disease, and the leading cause of premature death globally. Despite available therapeutic options, approximately half of the hypertensive population taking medication does not achieve adequate blood pressure (BP) control leaving them at increased risk of chronic kidney disease, renal failure, stroke, congestive heart failure, myocardial infarction, aneurysm and peripheral artery disease. New therapeutic options need to be identified for the treatment of hypertension i
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21

Flegge, Lindsay G., Eric Lake, Carnigee Truesdale, and Julia R. Craner. "Sex differences in interdisciplinary pain rehabilitation outcomes: a systematic review." Scandinavian Journal of Pain 22, no. 2 (2022): 218–31. http://dx.doi.org/10.1515/sjpain-2021-0188.

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Abstract Objectives Interdisciplinary pain rehabilitation programs (IPRPs) are evidence-based treatments for chronic pain. Previous research has demonstrated that initial presentations of adult men and women admitted to IPRPs differ, but less is known about sex differences in IPRP treatment outcomes. To summarize and synthesize the current literature base on this topic, a systematic literature review was conducted that asked: are sex differences present in participant outcomes upon completion of interdisciplinary pain rehabilitation programs for cisgender patients? Four core domains of outcome
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22

Yanovich, R., I. Ketko, and N. Charkoudian. "Sex Differences in Human Thermoregulation: Relevance for 2020 and Beyond." Physiology 35, no. 3 (2020): 177–84. http://dx.doi.org/10.1152/physiol.00035.2019.

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The participation of women in physically strenuous athletic and occupational tasks has increased substantially in the past decade. Female sex steroids have influences on thermoregulatory processes that could impact physical performance in the heat. Here, we summarize and evaluate the current literature regarding sex differences in thermoregulation and provide recommendations for heat-illness risk-mitigation strategies.
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23

Della Giusta, Marina, Maria Laura Di Tommaso, and Sarah Louise Jewell. "Men buying sex. Differences between urban and rural areas in the UK." Urban Studies 54, no. 3 (2016): 713–29. http://dx.doi.org/10.1177/0042098016645267.

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We build on both our theoretical and empirical work on modelling the demand for paid sex (Della Giusta et al., 2009a, 2009b) and examine the demand for paid sex, considering the effects of risky behaviours and attitudes to relationships and to women on demand. We find that those who declare to have purchased sex have both different socio-demographics (older, with fewer children, more educated but with lower professional status), and different sexual and risky behaviours as well as attitudes to relationships. As expected in the light of findings in the literature (well summarised in a 2004 Urba
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24

Byrd, DeAnnah R., Roland J. Thorpe, and Keith E. Whitfield. "EXPLORING SEX DIFFERENCES IN COGNITION IN OLDER BLACKS." Innovation in Aging 3, Supplement_1 (2019): S543. http://dx.doi.org/10.1093/geroni/igz038.1999.

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Abstract Previous literature suggest that women experience more dementia than men. However, it is unclear what accounts for these differences and whether sex differences exist among Blacks over time. We hypothesize that Black women will have worse cognitive outcomes than men and smoking may potentially explain these differences. Longitudinal data from the Baltimore Study of Black Aging-Patterns of Cognitive Aging was used to assess cognitive change over 33 months in five domains. The sample consisted of 602 community-dwelling Blacks, aged 48-92 years at baseline and 450 at follow-up. Findings
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Qian, Xinyu, Michelle L. Townsend, Wan Jie Tan, and Brin F. S. Grenyer. "Sex differences in borderline personality disorder: A scoping review." PLOS ONE 17, no. 12 (2022): e0279015. http://dx.doi.org/10.1371/journal.pone.0279015.

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Borderline Personality Disorder (BPD) is often perceived to be a female-predominant disorder in both research and clinical contexts. Although there is growing recognition of possible sex differences, the current literature remains fragmented and inconclusive. This scoping review aimed to synthesize available research evidence on potential sex differences in BPD. PsycINFO, PubMed, Scopus and Web-of-Science were searched from January 1982 to July 2022 surrounding the key concepts of sex and BPD. Data searching and screening processes followed the Joanna Briggs Institute methodology involving two
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Wele, Prachi, Xian Wu, and Haifei Shi. "Sex-Dependent Differences in Colorectal Cancer: With a Focus on Obesity." Cells 11, no. 22 (2022): 3688. http://dx.doi.org/10.3390/cells11223688.

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Colorectal cancer (CRC) is the third most common cancer and has the second highest cancer-related mortality in the world. The incident rates of CRC vary country-wise; however, population studies and data from different countries show a general increase in the CRC rate in young adults, males, and females ≥65 years. CRC incidence is affected by age, sex, environmental, dietary, hormonal, and lifestyle factors. Obesity is a known disease that is spreading rapidly throughout the world. A large body of literature indicates that, among many conditions, obesity is the increasing cause of CRC. Even th
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Dr. Sonia George, Sarika A,. "Sex Differences in Film induced Emotion: A narrative review." Psychology and Education Journal 58, no. 2 (2021): 5546–53. http://dx.doi.org/10.17762/pae.v58i2.2974.

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Humankind has been fascinated by perceived differences between men and women .There are several empirical literature on sexual differences in emotion .Film is considered as one of the most effective method to induce emotions in a laboratory settings. In this study, the sex -emotion debate from the results of 24 studies which induced emotions using films in experimental settings were analysed. The differences in expressive, experiential, and physiological emotional responses of men and women collected from the studies were assessed and the key findings across three dimensions: (a) overt actions
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Lenell, Charles, Courtney K. Broadfoot, Nicole E. Schaen-Heacock, and Michelle R. Ciucci. "Biological and Acoustic Sex Differences in Rat Ultrasonic Vocalization." Brain Sciences 11, no. 4 (2021): 459. http://dx.doi.org/10.3390/brainsci11040459.

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The rat model is a useful tool for understanding peripheral and central mechanisms of laryngeal biology. Rats produce ultrasonic vocalizations (USVs) that have communicative intent and are altered by experimental conditions such as social environment, stress, diet, drugs, age, and neurological diseases, validating the rat model’s utility for studying communication and related deficits. Sex differences are apparent in both the rat larynx and USV acoustics and are differentially affected by experimental conditions. Therefore, the purpose of this review paper is to highlight the known sex differe
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Bujak, Marta, Krzysztof Malinowski, Zbigniew Siudak, et al. "Sex Differences in Fractional Flow Reserve Utilization." Journal of Clinical Medicine 13, no. 14 (2024): 4028. http://dx.doi.org/10.3390/jcm13144028.

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Background: The literature review shows that female patients are more frequently underdiagnosed or suffer from delayed diagnosis. Recognition of sex-related differences is crucial for implementing strategies to improve cardiovascular outcomes. We aimed to assess sex-related disparities in the frequency of fractional flow reserve (FFR)-guided procedures in patients who underwent angiography and/or percutaneous coronary intervention (PCI). Methods: We have derived the data from the national registry of percutaneous coronary interventions and retrospectively analyzed the data of more than 1.4 mil
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Griesbeck, Morgane, Eileen Scully, and Marcus Altfeld. "Sex and gender differences in HIV-1 infection." Clinical Science 130, no. 16 (2016): 1435–51. http://dx.doi.org/10.1042/cs20160112.

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The major burden of the human immunodeficiency (HIV) type 1 pandemic is nowadays carried by women from sub-Saharan Africa. Differences in the manifestations of HIV-1 infection between women and men have been long reported, and might be due to both socio-economic (gender) and biological (sex) factors. Several studies have shown that women are more susceptible to HIV-1 acquisition than men. Following HIV-1 infection, women have lower viral loads during acute infection and exhibit stronger antiviral responses than men, which may contribute to differences in the size of viral reservoirs. Oestrogen
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O'Sullivan, Lucy, and Miho J. Tanaka. "Sex-based Differences in Hamstring Injury Risk Factors." Journal of Women's Sports Medicine 1, no. 1 (2021): 20–29. http://dx.doi.org/10.53646/jwsm.v1i1.8.

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Hamstring injuries (HSI) are common in a number of different sports and can confer a significant burden to both male and female athletes. Though research on HSIs in the female athlete population is lacking, current literature suggests male athletes are between two to four times more likely than female athletes to sustain an HSI. Despite this discrepancy, the role of intrinsic sex differences in HSI risk factors has not been previously explored. This review aims to summarize these sex-based differences in HSI risk factors and their influence on the lower rate of HSIs seen in female athletes as
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Rusman, Tamara, Rianne E. van Bentum, and Irene E. van der Horst-Bruinsma. "Sex and gender differences in axial spondyloarthritis: myths and truths." Rheumatology 59, Supplement_4 (2020): iv38—iv46. http://dx.doi.org/10.1093/rheumatology/keaa543.

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Abstract Mounting evidence reveals evident sex differences in physiology, disease presentation and response to medication in axial SpA (axSpA). Unfortunately these data are often neglected in clinical practice and research. In this review, myths that still exist on diagnosis, disease manifestation and drug effectiveness were argued against data of the most recent literature. The aim is to increase awareness of sex differences in the clinical aspects of axSpA.
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Labaka, Ainitze, Olatz Goñi-Balentziaga, Andrea Lebeña, and Joana Pérez-Tejada. "Biological Sex Differences in Depression: A Systematic Review." Biological Research For Nursing 20, no. 4 (2018): 383–92. http://dx.doi.org/10.1177/1099800418776082.

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Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher in women than in men. There is, however, a lack of data on sex-specific pathophysiology of this disorder. The purpose of this systematic review is to identify the biological sex differences found in major depressive disorder (MDD) in studies published in the last 10 years. We conducted a literature search using the Medline, PsycInfo, PubMed, and Web of Science databases, selecting English-language studies that included physiological measures compared by sex in addition to MDD. We identified 20 relevan
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El-Battrawy, Ibrahim, Kim Schlentrich, Johanna Besler, et al. "Sex-differences in short QT syndrome: A systematic literature review and pooled analysis." European Journal of Preventive Cardiology 27, no. 12 (2019): 1335–38. http://dx.doi.org/10.1177/2047487319850953.

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Etchell, Andrew, Aditi Adhikari, Lauren S. Weinberg, et al. "A systematic literature review of sex differences in childhood language and brain development." Neuropsychologia 114 (June 2018): 19–31. http://dx.doi.org/10.1016/j.neuropsychologia.2018.04.011.

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Asghar, Mariam, Muhammad Shariq Usman, Rafi Aibani, et al. "Sex Differences in Authorship of Academic Cardiology Literature Over the Last 2 Decades." Journal of the American College of Cardiology 72, no. 6 (2018): 681–85. http://dx.doi.org/10.1016/j.jacc.2018.05.047.

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Candeloro, Raffaella, Caterina Ferri, Tiziana Bellini, Maura Pugliatti, and Massimiliano Castellazzi. "Breaking Barriers: Unveiling Sex-Related Differences in Cerebrospinal Fluid Analysis—A Narrative Review." Biology 13, no. 6 (2024): 420. http://dx.doi.org/10.3390/biology13060420.

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(1) Background: The recent emphasis on sexual and gender diversity’s impact on human health underscores the need for tailored diagnostic and therapeutic approaches in neurology. The aim of this article is to conduct a narrative review of the available scientific literature on sex differences in cerebrospinal fluid analysis. (2) Methods: The literature search encompassed PubMed databases, focusing on cerebrospinal fluid analysis and sex differences, considering parameters like cerebrospinal fluid protein content, cell count, albumin quotient (QAlb) and intrathecal IgG synthesis. (3) Results: Ni
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Wade, Juli. "Genetic regulation of sex differences in songbirds and lizards." Philosophical Transactions of the Royal Society B: Biological Sciences 371, no. 1688 (2016): 20150112. http://dx.doi.org/10.1098/rstb.2015.0112.

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Sex differences in the morphology of neural and peripheral structures related to reproduction often parallel the frequency of particular behaviours displayed by males and females. In a variety of model organisms, these sex differences are organized in development by gonadal steroids, which also act in adulthood to modulate behavioural expression and in some cases to generate parallel anatomical changes on a seasonal basis. Data collected from diverse species, however, suggest that changes in hormone availability are not sufficient to explain sex and seasonal differences in structure and functi
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Sönmez, Hafize Emine, and Ezgi Deniz Batu. "DIFFERENCES IN BEHÇET’S DISEASE PHENOTYPE ACCORDING TO SEX: HYPOTHESES AND RESEARCH PERSPECTIVES." Central Asian Journal of Medical Hypotheses and Ethics 3, no. 3 (2022): 154–59. http://dx.doi.org/10.47316/cajmhe.2022.3.3.01.

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Behçet's disease (BD) is a multisystem vasculitis affecting both arteries and veins. Although the disease affects both sexes equally, males and females may express different phenotypes. The exact association between sex-related factors and BD phenotype is not clear, while many factors, such as genetic factors, hormones, and environmental and epigenetic factors may be the underlying factors of sex-related differences. This article summarizes the current literature focusing on the underlying factors determining differences in BD phenotype according to sex.
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Santollo, Jessica, Derek Daniels, Micah Leshem, and Jay Schulkin. "Sex Differences in Salt Appetite: Perspectives from Animal Models and Human Studies." Nutrients 15, no. 1 (2023): 208. http://dx.doi.org/10.3390/nu15010208.

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Salt ingestion by animals and humans has been noted from prehistory. The search for salt is largely driven by a physiological need for sodium. There is a large body of literature on sodium intake in laboratory rats, but the vast majority of this work has used male rats. The limited work conducted in both male and female rats, however, reveals sex differences in sodium intake. Importantly, while humans ingest salt every day, with every meal and with many foods, we do not know how many of these findings from rodent studies can be generalized to men and women. This review provides a synthesis of
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Jain, Angita, Nadine Norton, Katelyn A. Bruno, Leslie T. Cooper, Paldeep S. Atwal, and DeLisa Fairweather. "Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy." Journal of Clinical Medicine 10, no. 11 (2021): 2289. http://dx.doi.org/10.3390/jcm10112289.

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Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle and impaired systolic function and is the second most common cause of heart failure after coronary heart disease. The etiology of DCM is diverse including genetic pathogenic variants, infection, inflammation, autoimmune diseases, exposure to chemicals/toxins as well as endocrine and neuromuscular causes. DCM is inherited in 20–50% of cases where more than 30 genes have been implicated in the development of DCM with pathogenic variants in TTN (Titin) most frequently associated with disease. Even though male sex is
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42

Kerry, Nicholas, and Damian R. Murray. "Physical Strength Partly Explains Sex Differences in Trait Anxiety in Young Americans." Psychological Science 32, no. 5 (2021): 809–15. http://dx.doi.org/10.1177/0956797620971298.

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Among the most consistent sex differences to emerge from personality research is that women score higher than men on the Big Five personality trait Neuroticism. However, there are few functionally coherent explanations for this sex difference. The current studies tested whether this sex difference is due, in part, to variation in physical capital. Two preregistered studies (total N = 878 U.S. students) found that sex differences in the anxiety facet of Neuroticism were mediated by variation in physical strength and self-perceived formidability. Study 1 ( N = 374) did not find a predicted media
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Farkouh, André, Christoph Baumgärtel, Roman Gottardi, Margit Hemetsberger, Martin Czejka, and Alexandra Kautzky-Willer. "Sex-Related Differences in Drugs with Anti-Inflammatory Properties." Journal of Clinical Medicine 10, no. 7 (2021): 1441. http://dx.doi.org/10.3390/jcm10071441.

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There is increasing evidence of sex differences in the action of anti-inflammatory drugs, with women being at significantly higher risk of adverse effects. Nevertheless, clinicians’ awareness of the implications of these sex differences on dosing and adverse event monitoring in routine practice is still in need of improvement. We reviewed the literature evaluating sex differences in terms of pharmacokinetics and pharmacodynamics of anti-inflammatory drugs. The anti-thrombotic activity of selective and non-selective COX-inhibitors tends to be stronger in men than women. Side effect profiles dif
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Bozikas, Vasilis P., Mary H. Kosmidis, Apostolos Peltekis, et al. "Sex Differences in Neuropsychological Functioning Among Schizophrenia Patients." Australian & New Zealand Journal of Psychiatry 44, no. 4 (2010): 333–41. http://dx.doi.org/10.3109/00048670903489833.

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Objectives: Evidence from the literature addressing sex differences in cognition in schizophrenia remains equivocal, with some researchers suggesting that male schizophrenia patients are more impaired than female subjects, while others report no significant sex differences in cognitive functioning. The aim of the present study was to investigate whether the differential pattern of cognitive performance observed in healthy men and women is preserved in male and female schizophrenia patients. Method: Ninety-six schizophrenia patients (56 men) were compared with 62 age- and gender-ratio matched h
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Rich-Edwards, Janet W., Ursula B. Kaiser, Grace L. Chen, JoAnn E. Manson, and Jill M. Goldstein. "Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators." Endocrine Reviews 39, no. 4 (2018): 424–39. http://dx.doi.org/10.1210/er.2017-00246.

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Abstract A sex- and gender-informed perspective increases rigor, promotes discovery, and expands the relevance of biomedical research. In the current era of accountability to present data for males and females, thoughtful and deliberate methodology can improve study design and inference in sex and gender differences research. We address issues of motivation, subject selection, sample size, data collection, analysis, and interpretation, considering implications for basic, clinical, and population research. In particular, we focus on methods to test sex/gender differences as effect modification
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Vaura, Felix, Joonatan Palmu, Jenni Aittokallio, Anni Kauko, and Teemu Niiranen. "Genetic, Molecular, and Cellular Determinants of Sex-Specific Cardiovascular Traits." Circulation Research 130, no. 4 (2022): 611–31. http://dx.doi.org/10.1161/circresaha.121.319891.

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Despite the well-known sex dimorphism in cardiovascular disease traits, the exact genetic, molecular, and cellular underpinnings of these differences are not well understood. A growing body of evidence currently points at the links between cardiovascular disease traits and the genome, epigenome, transcriptome, and metabolome. However, the sex-specific differences in these links remain largely unstudied due to challenges in bioinformatic methods, inadequate statistical power, analytic costs, and paucity of valid experimental models. This review article provides an overview of the literature on
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Russillo, Maria Claudia, Valentina Andreozzi, Roberto Erro, et al. "Sex Differences in Parkinson’s Disease: From Bench to Bedside." Brain Sciences 12, no. 7 (2022): 917. http://dx.doi.org/10.3390/brainsci12070917.

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Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease and gender differences have been described on several aspects of PD. In the present commentary, we aimed to collect and discuss the currently available evidence on gender differences in PD regarding biomarkers, genetic factors, motor and non-motor symptoms, therapeutic management (including pharmacological and surgical treatment) as well as preclinical studies. Methods: A systematic literature review was performed by searching the Pubmed and Scopus databases with the search strin
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Sheridan, Lorraine P., Adrian C. North, and Adrian J. Scott. "Experiences of Stalking in Same-Sex and Opposite-Sex Contexts." Violence and Victims 29, no. 6 (2014): 1014–28. http://dx.doi.org/10.1891/0886-6708.vv-d-13-00072.

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Most stalking literature reports on male stalkers and female victims. This work examines stalking experiences in 4 sex dyads: male stalker–female victim, female stalker–male victim, female–female dyads, and male–male dyads. Respondents were 872 self-defined victims of stalking from the United Kingdom and the United States who completed an anonymous survey. The study variables covered the process of stalking, effects on victims and third parties, and victim responses to stalking. Approximately 10% of comparisons were significant, indicating that sex of victim and stalker is not a highly discrim
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De Mauro, Domenico, Cesare Meschini, Giovanni Balato, et al. "Sex-related differences in periprosthetic joint infection research." Journal of Bone and Joint Infection 9, no. 2 (2024): 137–42. http://dx.doi.org/10.5194/jbji-9-137-2024.

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Abstract. Introduction: Periprosthetic joint infections (PJIs) have emerged as a focal point in the realm of orthopedics, garnering widespread attention owing to the escalating incidence rates and the profound impact they impose on patients undergoing total joint arthroplasties (TJAs). Year after year, there has been a growing trend in the analysis of multiple risk factors, complication rates, and surgical treatments in the field. This study aims to illuminate the status of the sex-related differences in periprosthetic joint infections and advance research in this field. Methods: A systematic
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Gurvich, Caroline, Kate Hoy, Natalie Thomas, and Jayashri Kulkarni. "Sex Differences and the Influence of Sex Hormones on Cognition through Adulthood and the Aging Process." Brain Sciences 8, no. 9 (2018): 163. http://dx.doi.org/10.3390/brainsci8090163.

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Hormones of the hypothalamic-pituitary-gonadal (HPG) axis that regulate reproductive function have multiple effects on the development, maintenance and function of the brain. Sex differences in cognitive functioning have been reported in both health and disease, which may be partly attributed to sex hormones. The aim of the current paper was to provide a theoretical review of how sex hormones influence cognitive functioning across the lifespan as well as provide an overview of the literature on sex differences and the role of sex hormones in cognitive decline, specifically in relation to Alzhe
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