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Dissertations / Theses on the topic 'Sex hormone binding globulin (SHBG)'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

DUMOULIN, SYLVIE. "Effet des hormones thyroidiennes sur les glycoproteines de transport des steroides, shbg et cbg sur le rapport gbg/shbg." Toulouse 3, 1993. http://www.theses.fr/1993TOU31535.

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2

Jänne, Marja. "Regulation of human sex hormone-binding globulin gene (shbg) expression." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/janne/.

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3

杜偉麒 and Wai-ki Alex Tu. "Molecular cloning and characterization of rabbit sex hormone binding globulin (SHBG) complementary DNA." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31213716.

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4

Tu, Wai-ki Alex. "Molecular cloning and characterization of rabbit sex hormone binding globulin (SHBG) complementary DNA /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B14786965.

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5

Thorsteinson, Nels. "Computational ligand discovery for the human and zebrafish sex hormone binding globulin." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/943.

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Virtual screening is a fast, low cost method to identify potential small molecule therapeutics from large chemical databases for the vast amount of target proteins emerging from the life sciences and bioinformatics. In this work, we applied several conventional and newly developed virtual screening approaches to identify novel non-steroidal ligands for the human and zebrafish sex hormone binding globulin (SHBG). The ‘benchmark set of steroids’ is a set of steroids with known affinities for human SHBG that has been widely used for validation in the development of different virtual screening met

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6

DE, GLISEZINSKI ISABELLE. "Interet du dosage de la shbg dans l'evaluation du statut nutritionnel chez la personne agee." Toulouse 3, 1993. http://www.theses.fr/1993TOU31555.

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7

Vismer, Michael John. "An operational model for estrogenic action in the presence of sex hormone binding globulin (SHBG)." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/19887.

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Thesis (MSc)--University of Stellenbosch, 2007.<br>ENGLISH ABSTRACT: The aim of this study was to build a mathematical model that describes the binding of 17- -estradiol (E2) to estrogen receptor (ER- ) and the influence the sex hormone binding globulin (SHBG) has on this interaction. The influence of SHBG on the transactivation of an estrogen response element, via ligand bound ER- , was also studied. COS-1 cells, derived from the kidney of a green african monkey, were used to study the binding of E2 to ER- in the absence of SHBG. The influence of SHBG on the binding of E2 to ER- wa

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8

Cousin, Patrice. "Étude des formes circulantes de la Sex Hormone-Binding Globulin (SHBG) humaine, protéine de liaison des hormones stéroïdes sexuelles : mesure des clairances métaboliques." Lyon 1, 2000. http://www.theses.fr/2000LYO1T006.

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9

Forges, Thierry. "Etude de l'expression de la sex hormone-binding globulin (SHBG) dans les cellules de la granulosa humaines." Nancy 1, 2004. http://www.theses.fr/2004NAN11310.

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La sex hormone-binding globulin (SHBG), glycoprotéine hépatique, est classiquement considérée comme une protéine de liaison, assurant le transport des stéroïdes sexuels dans le sang et régulant leur biodisponibilité. Cependant, d'autres sites d'expression, ainsi que des récepteurs membranaires spécifiques ont été découverts dans certains tissus. L'interaction de la SHBG avec ces récepteurs déclenche la production d'un second messager et l'apparition d'un effet biologique. Le présent travail a pour but d'étudier l'expression de la SHBG dans les cellules de la granulosa humaines. D'abord, la pré

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10

Bendridi, Nadia. "Interaction de la protéine de transport plasmatique humaine des hormones stéroïdiennes sexuelles (Sex Steroid Hormone-Binding Globulin) (SHBG) avec un xéno-oestrogène, le Bisphénol A." Lyon 1, 2001. http://www.theses.fr/2001LYO1T093.

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11

Piontek, Kristin [Verfasser], Gustav [Akademischer Betreuer] Jirikowski, Karl Jürgen [Akademischer Betreuer] Bär, and Hans-Gert [Akademischer Betreuer] Bernstein. "Expression von Sex Hormone-Binding Globulin (SHBG) im Kleinhirn der Ratte während der Postnatalentwicklung / Kristin Piontek. Gutachter: Gustav Jirikowski ; Karl Jürgen Bär ; Hans-Gert Bernstein." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://d-nb.info/1063331390/34.

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12

Dalmazzo, Andressa. "Imunolocalização e expressão do receptor de ocitocina (OTR) e da globulina ligadora de hormônios sexuais (SHBG) em testículo e epidídimo de cães e suas correlações com a qualidade espermática." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-30092016-122716/.

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A ocitocina (OT) é um neuropeptídio hipotalâmico, que dentre suas funções na fêmea destaca-se a contração uterina durante o parto e a ejeção do leite. No entanto, estudos vêm demonstrando importantes funções endócrinas e parácrinas no trato reprodutivo masculino. Evidenciando a possível ação conjunta entre OT e a Globulina ligadora de hormônios sexuais (SHBG). Entretanto, em cães não existem informações disponíveis quanto sua atuação. Assim, estudos direcionados aos receptores de ocitocina (OTR) e SHBG e suas funções no sistema reprodutor masculino, mais especificamente na fisiologia espermáti

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13

Roche, Didier. "Intérêts des dosages de l'IGF-1 et de la SHBG dans l'évaluation du statut nutritionnel de la personne âgée." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M221.

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14

Kassab, Diana. "Localisation du site de liaison des stéroïdes de la protéine plasmatique de transport des stéroïdes ("Sex Hormone-Binding Globulin", "SHBG") de lapin et de mouton par photomarquage d'affinité avec la Δ6-testostérone et étude du rôle du stéroïde dans la dimérisation de fragments recombinants de SHBG humaine". Lyon 1, 1998. http://www.theses.fr/1998LYO1T145.

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15

Fareau-Saposnik, Béatrice. "Etude fonctionnelle du domaine homologue à la Sex Hormone Binding Globulin (SHBG) de la protéine S et relation génotype-phénotype du récepteur des cellules endothéliales de la protéine C (EPCR), deux cofacteurs du système de la protéine C." Paris 5, 2004. http://www.theses.fr/2004PA05P625.

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Trois cofacteurs interviennent dans le système anticoagulant naturel de la protéine C (PC) : la thrombomoduline (TM), le récepteur des cellules endothéliales à la PC (EPCR) et la protéine S (PS). Les deux premiers jouent un rôle dans la première étape du système, en permettant au zymogène qu'est la PC d'être activé en PC activée (PCa), tandis que la PS exerce son rôle de cofacteur en augmentant la vitesse de protéolyse des facteurs Va et VIIIa de la coagulation par la PCa, protéolyse qui limite la génération de thrombine. Si l'effet cofacteur de la TM est clair (elle accélère la réaction d'act

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16

Wu, Tsung-Sheng. "Functional characterization of sex hormone-binding globulin genetic polymorphism." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/53980.

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Human plasma SHBG is produced by the liver, and it transports biologically active sex steroids and determines their availability to target tissues. The 4.3 kb human SHBG transcriptional unit encoding a signal polypeptide for secretion followed by two laminin G (LG)-like domains is utilized by hepatocytes. The N-terminal LG domain of SHBG contains a region responsible for homodimer formation, and a steroid ligand-binding site that accommodates androgens and estrogens in opposite orientations. Among over 250 genetic polymorphisms identified in human SHBG, few are functionally characterized. In t

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17

Hong, Eui-ju. "Regulation of androgen action by sex hormone-binding globulin." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/35861.

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Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are

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18

Maisonet, Mildred, Antonia M. Calafat, Michele Marcus, Jouni J. K. Jaakkola, and Hany Lashen. "Prenatal Exposure to Perfluoroalkyl Acids and Serum Testosterone Concentrations at 15 Years of Age in Female ALSPAC Study Participants." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/1.

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Background: Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator–activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism. Because cholesterol is the substrate from which testosterone is synthesized, exposure to these substances has the potential to alter testosterone concentrations. Objectives: We explored associations of total testosterone and sex hormone–binding globulin (SHBG) concentrations at age 15 years with prenatal exposures to PFOS, PFOA, perfluorohexane sulfonic acid (PFHxS

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19

Fleming, Blaire O'Neil. "CHARACTERIZATION AND EVALUATION OF ANDROGEN-BINDING PROTEIN, SEX HORMONE-BINDING GLOBULIN, AND THYROXINE-BINDING GLOBULIN IN THE HORSE." UKnowledge, 2018. https://uknowledge.uky.edu/gluck_etds/37.

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The objectives of this study are to characterize two carrier proteins in the horse that significantly decrease in humans following anabolic androgenic steroid administration: sex hormone-binding globulin (SHBG) and thyroxine-binding globulin (TBG). For SHBG characterization, qPCR, RNA sequencing, and immunohistochemistry were performed on testes and equine livers. Free and total testosterone immunoassays were utilized to confirm the presence of a carrier protein in equine circulation. SHBG was detected in the testes using qPCR, RNA sequencing, and IHC, indicating the presence of the isoform an

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20

黃思齊 and Sze-tsai Alice Wong. "Expression of rabbit sex hormone binding globulin in Escherichia Coli." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31213777.

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21

Wong, Sze-tsai Alice. "Expression of rabbit sex hormone binding globulin in Escherichia Coli /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19627580.

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22

蘇敏婷 and Man-ting So. "Embryonic expression and alternative splicing of sex hormone-binding globulin mRNA." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3122667X.

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23

So, Man-ting. "Embryonic expression and alternative splicing of sex hormone-binding globulin mRNA /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23621564.

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24

Hamilton, Fairley. "Regulation of sex hormone binding globulin and insulin-like growth factor binding protein-1." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243549.

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25

Ip, Ying-chi. "Structure and transcriptional regulation of the rabbit sex hormone-binding globulin gene." Click to view the E-thesis via HKUTO, 2000. http://sunzi.lib.hku.hk/hkuto/record/B42575254.

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26

Ng, Kwong-man, and 吳廣文. "Sex hormone-binding globulin: protein-proteininteractions and identification of a novel isoform." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37640677.

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27

葉瑩芝 and Ying-chi Ip. "Structure and transcriptional regulation of the rabbit sex hormone-binding globulin gene." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B42575254.

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28

Ng, Kwong-man. "Sex hormone-binding globulin protein-protein interactions and identification of a novel isoform /." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37640677.

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29

周楚穎 and Chor-wing Vivian Ng. "Characterization and sequencing of sex hormone-binding globulin in common carp (cyprinus carpio)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31224982.

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30

Sy, Dicken. "Characterization and purification of sex hormone binding globulin in the common carp (Cyprinus carpio) /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19470484.

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31

施德恒 and Dicken Sy. "Characterization and purification of sex hormone binding globulin in the common carp (Cyprinus carpio)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31219901.

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32

Coviello, Andrea D., Robin Haring, Melissa Wellons, et al. "A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation." Uppsala universitet, Metabola bensjukdomar, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181141.

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Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an additional six studies. We identified twelve genomic regions (SNPs) associated with circulating SHBG co

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33

Baker, Erin R. "The Impact of Adiposity on Estrone, Estradiol, Testosterone and Sex Hormone Binding Globulin in Peripubertal Females." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282577554.

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34

Meyers, Warren. "Studies on the transcriptional regulation of human sex hormone-binding globulin in testicular germ cells : mechanistic and evolutionary insights." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58892.

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In most mammals, the major site of sex hormone-binding globulin (SHBG) synthesis is the liver wherefrom it is secreted into the bloodstream and is the primary determinant of sex steroid access to target tissues. The minor site of SHBG synthesis is the testis and in lower mammals testicular SHBG has long been known to be synthesized and secreted by Sertoli cells. In contrast, human SHBG is expressed in testicular germ cells from an upstream alternative promoter (altP-SHBG).Transcripts arising from this region comprise an alternative first exon (1A) and the resultant protein is confined to the a

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35

Chambon, Christophe. "Etude du site de liaison des stéroïdes de la protéine plasmatique humaine de transport des stéroïdes ("Sex Hormone-Binding Globulin") par photomarquage d'affinité." Lyon 1, 1997. http://www.theses.fr/1997LYO10231.

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La sex hormone binding globulin humaine (shbg) est une glycoproteine de transport liant la 5-dihydrotestosterone (dht), la testosterone et l'oestradiol, dont le role biologique est la regulation de la biodisponibilite des hormones steroides sexuelles. Dans le plasma, la shbg est un homodimere ayant un seul site de liaison des steroides par dimere. Des etudes anterieures de marquage d'affinite et de mutagenese dirigee ont localise une partie du site de liaison au niveau de la met-139. Le but de cette etude est de caracteriser d'autres acides amines a proximite du site de liaison par photomarqua

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36

Varin, Frédérique. "Intérêt de la détermination de quelques marqueurs périphériques dans le diagnostic et le traitement des dysthyroi͏̈dies." Paris 5, 1988. http://www.theses.fr/1988PA05P228.

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37

Kozlovienė, Dalia. "Padidėjusio moterų kūno plaukuotumo sąsajų su biocheminiu hiperandrogenizmu įvertinimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20060125_130116-46058.

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Objective To determine the relationship between increased body hair growth in women and serum sex hormone level, body mass index, and clinical signs. Sample and methods The sample group consisted of 186 women, 18–35 year old residents of Lithuania who were referred to the Clinic of Endocrinology, Kaunas University of Medicine Hospital in 2002–2004 and complained for increased body hair growth. Exclusion criteria: 1) taking systemic medications within the period shorter than three months before the beginning of the study; 2) specific reasons of excessive body hair growth, such as androgen secr

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38

Sparks, Patricia Lynne. "The relationship of vitamin D and selected nutrient intakes, sex hormone binding globulin and markers of bone turnover to bone mineral density in exercising and non-exercising postmenopausal women taking or not taking HRT." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/289711.

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The loss of bone mineral density (BMD) plays a major role in the increased incidence of osteoporosis in aging women and, consequently, strategies to maintain BMD are critical to quality of life for these women. The role of vitamin D in the accrual and maintenance of bone mineral and its relationship to the incidence and severity of osteoporosis is not well understood. By measuring serum and intake levels this study investigates the relationship of vitamin D to baseline BMD and changes in regional and total body BMD over 1 y. The role of sex hormone binding globulin (SHBG) is also investigated.

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39

Velayoudom-Cephise, Fritz-Line. "Profil métabolique associé au statut en vitamine D et polymorphismes des gènes codant son récepteur et transporteur spécifique dans une population caribéenne. : Parametres associés à la "sex hormone binding globulin "dans une population dysmétabolique caucasienne." Thesis, Antilles-Guyane, 2012. http://www.theses.fr/2012AGUY0536/document.

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En Guadeloupe, la prévalence du diabète est deux fois plus élevée qu'en France hexagonale, avec une prédominance féminine. En dehors des facteurs environnementaux, la vitamine D et certains polymorphismes de gènes impliqués dans son métabolisme seraient associés à un risque de pathologies métaboliques. Les androgènes sont également associés aux anomalies du métabolisme glucidique, soit directement, soit via leur transporteur SHBG (Sex Hormone Binding Protein). Nous avons émis les hypothèses de recherche suivantes: 11 le statut en vitamine D et les polymorphismes des gènes impliqués dans son mé

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40

Hébert-Losier, Andréa 1983. "Structural and functional characterization of a novel endogenous steroid, estradienolone (ED), in human pregnancy." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116111.

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Our lab has previously reported the identification of a novel endogenous 19-nor steroid, estradienolone (ED), in pregnant women that strongly bound to sex hormone binding globulin. Estrogen-receptor related receptors (ERRs), which have no known natural ligands, are a family of orphan receptors consisting of 3 isoforms: ERRalpha, ERRbeta and ERRgamma. The ERRs have been shown to actively modulate estrogenic responses, to play an essential role in pregnancy, and are implicated in breast cancer prognosis. My results show that ED acts as an antagonist of the ERRalpha confirming preliminary results

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41

Callou, Emmanuela Quental [UNIFESP]. "Testosterona, estradiol e doença arterial coronariana em homens adultos." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/10114.

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Made available in DSpace on 2015-07-22T20:50:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-04-28<br>Introdução: As doenças cardiovasculares (DCVs) representam o principal grupo de causa de morte no Brasil, com destaque para doença arterial coronariana (DAC). O sexo masculino apresenta maior incidência e mortalidade por DAC que o feminino. Uma das explicações para o fato era o possível efeito deletério da Testosterona no sistema cardiovascular masculino e o efeito protetor do Estradiol no sistema cardiovascular feminino. Contudo, evidências recentes da literatura apontam para um

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42

Lukanova, Annekatrin. "Endogenous hormones in the etiology of ovarian and endometrial cancers." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215.

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43

Wang, Q. (Qin). "Epidemiological applications of quantitative serum NMR metabolomics:causal inference from observational studies." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526215082.

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Abstract Cardiovascular diseases are the leading cause of death worldwide and type 2 diabetes is reaching a global epidemic. Epidemiological studies have identified numerous risk factors and pharmacotherapies in relation to these cardiometabolic diseases. However, the detailed molecular mechanisms of these risk factors and drug therapies generally remain incompletely understood. Elucidating the underlying molecular effects would be essential for better understanding of the disease pathogenesis and also for discovering new therapeutic targets. Quantitative serum metabolomics, which allows for s

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44

Hugon-Rodin, Justine. "La maladie veineuse thromboembolique : impact de la contraception hormonale estroprogestative Mechanisms in endocrinology: Epidemiology of hormonal contraceptives related thromboembolism. Eur J Endocrinol Sex hormone-binding globulin and thrombin generation in women using hormonal contraception First venous thromboembolism and hormonal contraceptives in young French women Combined hormonal contraceptives and first venous thrombosis in young French women: impact of thrombotic family history Type of combined contraceptives, factor V Leiden mutation and risk of venous thromboembolism: a case-only study." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS151.

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La contraception hormonale combinée (CHC) est la contraception la plus utilisée en France. La maladie veineuse thromboembolique (MVTE), constitue le principal effet délétère de ces CHC. Des recommandations de bonnes pratiques sont publiées pour guider les prescripteurs. La meilleure compréhension des modifications biologiques associées aux différents types de CHC, les caractéristiques cliniques des femmes ayant eu une MVTE, la place de la recherche d’antécédents familiaux de MVTE (AFVTE) et d’une thrombophilie biologique avant la prescription d’une CHC constituent des pistes de recherche qui p

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45

Göthe, Susanne [Verfasser]. "Expression und topographische Verteilung von Sex-Hormone-Binding-Globulin (SHBG) im Hypothalamus des Menschen / von Susanne Göthe." 2007. http://d-nb.info/985879815/34.

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46

Gyawali, Prabin. "Sex Hormone-Binding Globulin: Regulation and Role as a Marker of Chronic Disease Risk." Thesis, 2019. http://hdl.handle.net/2440/120693.

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Sex hormone-binding globulin (SHBG) is dimeric glycoprotein synthesised in hepatocytes and secreted into the circulation. SHBG binds sex-steroids and protects them from rapid degradation. SHBG is involved in the regulation of de novo lipogenesis in the liver. The synthesis and secretion of SHBG from the liver are regulated by hormonal, metabolic, nutritional, and genetic factors. There is increasing interest in SHBG because it is a determinant of total testosterone (TT) concentration, and maybe a marker of cardiometabolic disease risk. There are little data available from population-based stud

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47

Schock, Henning Wolfgang. "Expression von Sex Hormone-Binding Globulin und Androgenrezeptoren in Myokardbiopsien von Patienten mit dilatativer Kardiomyopathie /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013329021&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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48

Schock, Henning Wolfgang [Verfasser]. "Expression von Sex-Hormone-binding-Globulin und Androgenrezeptoren in Myokardbiopsien von Patienten mit dilatativer Kardiomyopathie / von Henning Wolfgang Schock." 2004. http://d-nb.info/975415824/34.

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49

Winter, Anika [Verfasser]. "Lokalisation von Sex-Hormone-binding-Globulin im Gehirn der Maus : Colokalisation mit Estrogen-Rezeptor α [alpha] im Mausgehirn / von Anika Winter". 2008. http://d-nb.info/989734072/34.

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Yang, Hsiao-Ping, and 楊曉萍. "Decrease of Sex Hormone -Binding Globulin, Increase of Sleep Apnea/Hypopnea Event, and Worsened Heart Rate Variability Contribute to the Cardiovascular Risk in Non-Obese Women with Polycystic Ovary Syndrome." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/28789780695685142506.

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Abstract:

博士<br>臺北醫學大學<br>保健營養學研究所<br>98<br>The prevalence of obstructive sleep apnea (OSA) in obese or overweight women with polycystic ovary syndrome (PCOS) is higher than that in control groups in Western countries. Both OSA and PCOS share insulin resistance (IR) as central pathogenesis. Preliminary data also revealed heart rate variability (HRV) changes that indicate an increase risk for CVD in PCOS. However, obesity is a confounding factor in studying OSA and HRV in PCOS. Our main purpose is that, by excluding the influence of obesity, patients with PCOS still present certain levels of biochemical

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