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Journal articles on the topic 'Singular and Hyphenated Techniques'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Prem, Lata Meena, Sandilya Avinash, and Sharma Sachin. "A review of Singular and Hyphenated Analytical techniques in Trace Element analysis." Chemistry Research Journal 4, no. 1 (2019): 117–24. https://doi.org/10.5281/zenodo.13752764.

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At micro trace levels there is a critical need for preconcentration, selective separation, and determine the various metal ions from complex matrices. Trace analysis and various analytical techniques which are used to determine the concentration of a chemical element is described. It can be broadly classified in to singular and hyphenated techniques. For analysis there are different types of singular techniques like Flame Atomic absorption spectroscopy (AAS),Neutron activation analysis (NAA),Graphite furnace atomic absorption spectrometry (GFAAS), inductively coupled p

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2

Albert, Klaus, Manfred Krucker, Tobias Glaser, Alexandre Schefer, Annette Lienau, and Daniel Zeeb. "Hyphenated techniques." Analytical and Bioanalytical Chemistry 372, no. 1 (2001): 25–26. http://dx.doi.org/10.1007/s00216-001-1158-x.

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3

Redant, Guido. "Hyphenated techniques in chromatography." TrAC Trends in Analytical Chemistry 11, no. 6 (1992): X—XI. http://dx.doi.org/10.1016/0165-9936(92)80040-d.

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4

Redant, G. "Hyphenated techniques in chromatography." TrAC Trends in Analytical Chemistry 13, no. 7 (1994): v—vi. http://dx.doi.org/10.1016/0165-9936(94)87059-4.

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5

Shubham, Rathod* Samrin Sheikh. "Hyphenated Techniques: A Powerful Tool for Complex Analysis." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 968–74. https://doi.org/10.5281/zenodo.14864515.

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Hyphenated techniques, which combine two or more analytical methods, have emerged as a powerful tool for complex analysis. By integrating separation, identification, and quantification capabilities, hyphenated techniques provide comprehensive insights into complex samples. This approach enhances sensitivity, specificity, and efficiency, enabling researchers to tackle challenging analytical problems. Applications of hyphenated techniques are diverse, spanning pharmaceuticals, environmental monitoring, food safety, biomedical research, and forensics. Techniques such as GC-MS, LC-MS, and CE-MS ha

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6

Goff, Loretta. "The Hyphenated Persona: Aidan Quinn’s Irish-American Performances." Persona Studies 3, no. 1 (2017): 60–75. http://dx.doi.org/10.21153/ps2017vol3no1art646.

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This article examines the hyphenated Irish-American identity performed by actor Aidan Quinn across a number of his media appearances. Hyphenated identities are frequently used in our increasingly globalised, migratory world to consolidate two or more national identifications into a singular, new identity. However, the performances of such identities are often complicated by shifting levels of identification, in line with the concept of identity salience, which result in multiple, protean identity performances—from either side of the hyphen—drawn upon as needed. “Celebrity identities” as a cons

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Willmann, Jan, and Dieter Leibfritz. "Hyphenated techniques in clinical Phospholipidomics." Chemistry and Physics of Lipids 154 (August 2008): S3—S4. http://dx.doi.org/10.1016/j.chemphyslip.2008.05.011.

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8

Mechref, Yehia, and Milos V. Novotny. "Editorial: Glycomics through hyphenated techniques." Mass Spectrometry Reviews 28, no. 2 (2008): 191. http://dx.doi.org/10.1002/mas.20209.

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9

Albert, Klaus. "Guest editor's foreword: Hyphenated techniques." Magnetic Resonance in Chemistry 43, no. 9 (2005): 680. http://dx.doi.org/10.1002/mrc.1637.

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10

Al, Serhun, and Daniel Karell. "Hyphenated Turkishness: The plurality of lived nationhood in Turkey." Nationalities Papers 44, no. 1 (2016): 144–64. http://dx.doi.org/10.1080/00905992.2015.1087485.

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Is Turkish nationality one singular identity that does not permit ethnic modifiers? Or can it be understood as pluralistic, with identities nested — “hyphenated” — with Turkishness? Then, are Turkish and Kurdish identities necessarily mutually exclusive? Such questions over the boundaries of Turkishness have long been framed in the civic versus ethnic dichotomy — an approach that does not ask whether Turkish nationhood is monolithic or pluralistic. In response, this article aims to advance the public and scholarly debates over nationhood in Turkey by turning to the question of ways in which Tu

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11

Daram Sushma Reddy Department of Pharmaceutical Analysis, Unnava Jaya Surya, Utukuri Satish, Thulugu Dhanalakshmi, Yatavelli Koushit Reddy, and Yanamala Gopi Krishna. "Hyphenated technologies: Transforming analytical approaches with combined methodologies." International Journal of Science and Research Archive 14, no. 1 (2025): 1431–44. https://doi.org/10.30574/ijsra.2025.14.1.0210.

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The hyphenated technique was developed by combining a separation strategy with an on-line spectroscopic detection technology. Currently, a combination of a separation approach with a more sensitive detection technique is the most used method for determining the speciation of trace elements. Before the addition of a detection approach, such hyphenated techniques involved coupling the separation of a unique sample preparation offline. Currently, a separation method (chromatography) and an online spectroscopic detection method are combined to create the hyphenated technique. Over the past two dec

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12

Armstrong, Gordon, and Lekshmi Kailas. "Hyphenated analytical techniques for materials characterisation." European Journal of Physics 38, no. 5 (2017): 053001. http://dx.doi.org/10.1088/1361-6404/aa7e93.

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13

Ramos, L. "Sample preparation for hyphenated analytical techniques." TrAC Trends in Analytical Chemistry 24, no. 5 (2005): III—IV. http://dx.doi.org/10.1016/j.trac.2005.01.014.

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14

Gurka, Donald F., L. Donnelly Betowski, Thomas A. Hinners, Edward M. Heithmar, Richard Titus, and John M. Henshaw. "Environmental Applications of Hyphenated Quadrupole Techniques." Analytical Chemistry 60, no. 7 (1988): 454A—467A. http://dx.doi.org/10.1021/ac00158a733.

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15

Łobiński, Ryszard, and Joanna Szpunar. "Biochemical speciation analysis by hyphenated techniques." Analytica Chimica Acta 400, no. 1-3 (1999): 321–32. http://dx.doi.org/10.1016/s0003-2670(99)00628-5.

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16

Theodoridis, Georgios, and Ian D. Wilson. "Hyphenated techniques for global metabolite profiling." Journal of Chromatography B 871, no. 2 (2008): 141–42. http://dx.doi.org/10.1016/j.jchromb.2008.07.003.

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17

Guetens, G., G. De Boeck, M. S. Highley, et al. "Hyphenated techniques in anticancer drug monitoring." Journal of Chromatography A 976, no. 1-2 (2002): 239–47. http://dx.doi.org/10.1016/s0021-9673(02)01227-x.

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18

Guetens, G., G. De Boeck, M. Wood, et al. "Hyphenated techniques in anticancer drug monitoring." Journal of Chromatography A 976, no. 1-2 (2002): 229–38. http://dx.doi.org/10.1016/s0021-9673(02)01228-1.

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19

Cserháti, Tibor, and Esther Forgács. "Hyphenated Techniques in Thin-Layer Chromatography." Journal of AOAC INTERNATIONAL 81, no. 2 (1998): 329–32. http://dx.doi.org/10.1093/jaoac/81.2.329.

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abstract This special report deals with the critical evaluation of the present state of hyphenated techniques in thin-layer chromatography, the enumeration of possible advantages and disadvantages of the newest developments, and prerequisites for the successful application of the newest results.

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20

Pasch, Harald. "Hyphenated separation techniques for complex polymers." Polymer Chemistry 4, no. 9 (2013): 2628. http://dx.doi.org/10.1039/c3py21095b.

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21

Komal, Zade* Mrunali Ahirrao Madhuri Shirsath Tufail Dana M. B. Nikam. "HPLC and its Hyphenated Techniques: Review." International Journal of Scientific Research and Technology 2, no. 5 (2025): 584–99. https://doi.org/10.5281/zenodo.15529234.

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High Performance Liquid Chromatography (HPLC) is a precise analytical technique used to separate, identify, and quantify components within complex mixtures. Developed in the late 1960s, it operates by pumping a liquid mobile phase under high pressure (50–350 bars) through a column packed with solid adsorbents like silica or polymers, which interact differently with each sample component to achieve separation. HPLC is favored in pharmaceuticals, biotechnology, environmental testing, and food industries for its speed, sensitivity, and high resolution. Hyphenated techniques in liquid chroma

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22

Khan, Zain Ul Bashar, Mukund Panukanti, V. Hanma, Anushree Hari, and Dr Lalith Sagar Reddy Gade. "Emerging Hyphenated Techniques in Pharmaceutical Analysis: A Systematic Review." International Journal of Research and Scientific Innovation XII, no. VII (2025): 153–67. https://doi.org/10.51244/ijrsi.2025.120700016.

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The pharmaceutical industry demands increasingly sophisticated analytical methods to meet stringent regulatory requirements and ensure drug safety and efficacy. Traditional single analytical techniques often fall short in providing comprehensive information about complex pharmaceutical matrices. This systematic review examines the current state and emerging trends of hyphenated techniques in pharmaceutical analysis, focusing on their applications, advantages, and future prospects. A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science databases, covering publ

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23

S, Thangadurai, B. Sithi Asma, A. Palanimurugan, and A. Cyril. "A Forensic Appraisal of Neoteric Hyphenated Techniques for Separation and Detection of Narcotic Drugs." International Journal of Forensic Sciences 10, no. 1 (2025): 1–17. https://doi.org/10.23880/ijfsc-16000430.

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Narcotic drugs are traditionally been identified on basis of chromatographic-hyphenated techniques in instrumental analysis. Nowadays, contemporary neoteric chromatographic hyphenated techniques have received ever-increasing attention because the principal means to unravel complex analytical problems. A legal examination is a term articulated for examination of all sorts of violations that leads to the prove for any sort of wrong doing as a conclusion of the suspect. Forensic laboratories drugs are identified and separated by TLC, HPLC, HPTLC, GC, LC and known hyphenated techniques which are l

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24

Shounak, Mande*. "A Review Article on Hyphenated Techniques Used in Analytical Method and Development." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 2407–17. https://doi.org/10.5281/zenodo.14762916.

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The hyphenated techniques refers to the combination or synthesis of distinct analytical methodologies. Spectroscopic techniques are mostly paired with chromatographic techniques. After that, an interphase will allow the mixture's separated components from the chromatographic approach to enter the spectroscopic technique. In GC-MS After separation from gas chromatography, ionization and mass spectrometry are added to MS. analysis and measurement of the mass-to-charge ratios of the ions that the mass spectrometer generates from each analysis. GC and MS can be connected by a membrane separator, j

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25

Zhang, Lv Yin, Xiao Ping Yu, Ya Fei Guo, and Tian Long Deng. "Selenium Species Analysis by Chromatography Hyphenated Techniques." Applied Mechanics and Materials 71-78 (July 2011): 2614–17. http://dx.doi.org/10.4028/www.scientific.net/amm.71-78.2614.

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Selenium species analysis based on chromatography hyphenated techniques including reversed-phase, ion-exchange, size exclusion, affinity chromatography and so on were summarized in this paper, and the new trend for selenium species analysis in the future was also carried out.

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26

DAI, Shu-Gui, and Chong-Bong JIA. "Applications of Hyphenated Techniques in Environmental Analysis." Analytical Sciences 12, no. 2 (1996): 355–61. http://dx.doi.org/10.2116/analsci.12.355.

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27

Szpunar, Joanna. "Bio-inorganic speciation analysis by hyphenated techniques." Analyst 125, no. 5 (2000): 963–88. http://dx.doi.org/10.1039/a909137h.

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28

Bogusz, M. J. "Hyphenated liquid chromatographic techniques in forensic toxicology." Journal of Chromatography B: Biomedical Sciences and Applications 733, no. 1-2 (1999): 65–91. http://dx.doi.org/10.1016/s0378-4347(98)00520-9.

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29

Donard, O. F. X., and F. M. Martin. "Hyphenated techniques applied to environmental speciation studies." TrAC Trends in Analytical Chemistry 11, no. 1 (1992): 17–26. http://dx.doi.org/10.1016/0165-9936(92)80115-m.

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30

Donard, O. "Hyphenated techniques applied to environmental speciation studies." TrAC Trends in Analytical Chemistry 11, no. 1 (1992): 27–32. http://dx.doi.org/10.1016/0165-9936(92)87028-i.

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31

Tsalev, Dimiter L. "Hyphenated vapour generation atomic absorption spectrometric techniques." Journal of Analytical Atomic Spectrometry 14, no. 2 (1999): 147–62. http://dx.doi.org/10.1039/a807304j.

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32

Senten, J. R. "Fourth International Symposium on Hyphenated Techniques in Chromatography & Hyphenated Chromatographic Analyzers (HTC 4)." Environmental Conservation 23, no. 3 (1996): 269. http://dx.doi.org/10.1017/s0376892900038881.

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33

Krishnan, Sadagopan, Sathya Samaraweera, Zia Syed, and Rahul Pandit Kumarchinchole. "(Invited) Hyphenated Electrochemical and Colorimetric Oligonucleotide Sensor." ECS Meeting Abstracts MA2025-01, no. 60 (2025): 2925. https://doi.org/10.1149/ma2025-01602925mtgabs.

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Hyphenated techniques enhance scientific rigor and reliability in diagnostic results by utilizing two orthogonal detection modes. Beyond this core advantage, hyphenated sensors provide complementary benefits that are not achievable with individual sensing methods. Notably, these techniques offer enhanced sensitivity, where one method serves as a binary yes/no test while the other achieves much lower detection limits tailored to specific clinical diagnostic needs. Additionally, the use of two distinct transduction mechanisms improves the ability to understand and address real sample detection c

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34

Wang, Han, Xiaolan Liu, Kai Nan, Beibei Chen, Man He, and Bin Hu. "Sample pre-treatment techniques for use with ICP-MS hyphenated techniques for elemental speciation in biological samples." Journal of Analytical Atomic Spectrometry 32, no. 1 (2017): 58–77. http://dx.doi.org/10.1039/c6ja00077k.

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This review will focus specifically on the state of the art of novel sample pretreatment methods which have been combined with ICP-MS based hyphenated techniques for elemental speciation in biological samples.

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35

Cumeras, R., E. Figueras, C. E. Davis, J. I. Baumbach, and I. Gràcia. "Review on Ion Mobility Spectrometry. Part 2: hyphenated methods and effects of experimental parameters." Analyst 140, no. 5 (2015): 1391–410. http://dx.doi.org/10.1039/c4an01101e.

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36

Amir, Mohammad, Puneet Narula, and Farzana Bano. "Analytical Techniques for the Analysis of Lopinavir and Ritonavir in Pharmaceutical Dosage Form and Biological Matrices: A Review." Current Pharmaceutical Analysis 18, no. 4 (2022): 380–414. http://dx.doi.org/10.2174/1573412918666211217145200.

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Background: Lopinavir and Ritonavir are protease inhibitor type of anti-retroviral drugs. Both are used for the treatment of HIV/AIDS. This paper reviews many analytical methods for the analysis of LPV and RTV in pharmaceutical formulations (tablet, capsule, syrup, and bulk) and biological fluids (human plasma, serum, cerebrospinal fluid, rat plasma, and human hair). Objective: The study aims to summarize various analytical techniques, such as chromatography and spectrophotometry, and also hyphenated techniques, such as LC-MS/MS and UPLC-MS, for the analysis of Lopinavir and Ritonavir. Method:

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37

Veresmortean, Cristina, and Adrian Covaci. "Hyphenated and non-hyphenated chromatographic techniques for trace level explosives in water bodies – a review." International Journal of Environmental Analytical Chemistry 98, no. 5 (2018): 387–412. http://dx.doi.org/10.1080/03067319.2018.1478969.

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38

Ričanyová, Júlia, Renata Gadzała-Kopciuch, Katarína Reiffová, and Bogusław Buszewski. "Estrogens and Their Analytics by Hyphenated Separation Techniques." Critical Reviews in Analytical Chemistry 39, no. 1 (2009): 13–31. http://dx.doi.org/10.1080/10408340802569506.

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39

Redant, G. "1st international symposium on hyphenated techniques in chromatography." TrAC Trends in Analytical Chemistry 9, no. 6 (1990): 183–85. http://dx.doi.org/10.1016/0165-9936(90)87040-s.

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40

Szpunar, Joanna, Ryszard Lobinski, and Andreas Prange. "Hyphenated Techniques for Elemental Speciation in Biological Systems." Applied Spectroscopy 57, no. 3 (2003): 102A—112A. http://dx.doi.org/10.1366/000370203321558128.

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41

McGaw, B. A. "Directory of hyphenated techniques—TrAC supplement no. 2." Talanta 42, no. 12 (1995): 2087–88. http://dx.doi.org/10.1016/0039-9140(95)90033-0.

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42

Pasch, Harald, Martina Adler, Daniela Knecht, Frank Rittig, and Ronald Lange. "New Chromatographic and Hyphenated Techniques for Hydrophilic Copolymers." Macromolecular Symposia 231, no. 1 (2005): 166–77. http://dx.doi.org/10.1002/masy.200590021.

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43

Zhao, Jianming, Manuel Cano, Juan J. Giner-Casares, Rafael Luque, and Guobao Xu. "Electroanalytical methods and their hyphenated techniques for novel ion battery anode research." Energy & Environmental Science 13, no. 9 (2020): 2618–56. http://dx.doi.org/10.1039/d0ee01184c.

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44

Kumar, Sachil, and Maciej J. Bogusz. "Hyphenated Techniques in Liquid Chromatography and their Applications in Forensic Toxicology." Journal of Forensic Science and Medicine 7, no. 4 (2021): 123–36. http://dx.doi.org/10.4103/jfsm.jfsm_65_21.

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Conventional analytical methods, such as gas chromatography, high performance liquid chromatography (LC), ultra-violet, and others, are ineffective in addressing the increasing number of problems in forensic toxicology. Hyphenated analytical methods, wherein the separation method are coupled or combined with spectral methods, with the help of a proper interface, are the available alternative options. The key benefits of these methods are the requisites of low limits for detection, shorter analytical time, the possibility of automation, better reproducibility, and high precision and repeatabili

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45

H S, Akshatha, and Gurupadayya Bm. "APPLICATION OF LIQUID CHROMATOGRAPHY COUPLED WITH MASS SPECTROMETRY IN THE IMPURITY PROFILING OF DRUG SUBSTANCES AND PRODUCTS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 30. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24212.

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As the drug safety and efficacy is hampered in the presence of an impurity, the international regulatory agencies laid down stringent limits for the control of impurities in the active pharmaceutical ingredient and pharmaceutical formulations. The conventional approaches lack the characterization of impurities in trace levels, due to sensitivity issues, hyphenated techniques are preferred. Among the modern hyphenated techniques, liquid chromatography-mass spectrometry (LC-MS) has high sensitivity and can analyze large number of organic compounds in a short period of time. In the present study,

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46

Nehmeh, Bilal, Fatima Haydous, and Elias Akoury. "Mass calibrants for positive chemical ionization-high resolution mass spectrometry (CI-HRMS) for the identification of unknown compounds using accurate mass measurements." RSC Advances 13, no. 20 (2023): 14001–9. http://dx.doi.org/10.1039/d3ra01977b.

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47

Gould, Oliver, Natalia Drabińska, Norman Ratcliffe, and Ben de Lacy Costello. "Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body." Molecules 26, no. 23 (2021): 7185. http://dx.doi.org/10.3390/molecules26237185.

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Mass spectrometry (MS) is an analytical technique that can be used for various applications in a number of scientific areas including environmental, security, forensic science, space exploration, agri-food, and numerous others. MS is also continuing to offer new insights into the proteomic and metabolomic fields. MS techniques are frequently used for the analysis of volatile compounds (VCs). The detection of VCs from human samples has the potential to aid in the diagnosis of diseases, in monitoring drug metabolites, and in providing insight into metabolic processes. The broad usage of MS has r

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48

Tanna, Sangeeta, John Ogwu, and Graham Lawson. "Hyphenated mass spectrometry techniques for assessing medication adherence: advantages, challenges, clinical applications and future perspectives." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 5 (2020): 643–63. http://dx.doi.org/10.1515/cclm-2019-0820.

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AbstractNonadherence to prescribed pharmacotherapy is an understated public health problem globally and is costing many patients their chance to return to good health and healthcare systems billions. Clinicians need an accurate assessment of adherence to medications to aid the clinical decision-making process in the event of poor patient progress and to maximise the patient health outcomes from the drug therapies prescribed. An overview of indirect and direct methods used to measure medication adherence is presented, highlighting the potential for accurate measuring of drugs in biological samp

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49

Shirgaonkar, Rushikesh, Aniket Lomate, and Sachin A Pishawikar. "Hyphenated Techniques, an Important Tool for Force Degradation Study." Acta Scientific Pharmaceutical Sciences 4, no. 9 (2020): 23–28. http://dx.doi.org/10.31080/asps.2020.04.0581.

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50

Patel, KalpeshN, JayvadanK Patel, ManishP Patel, GaneshC Rajput, and HiteshA Patel. "Introduction to hyphenated techniques and their applications in pharmacy." Pharmaceutical Methods 1, no. 1 (2010): 2. http://dx.doi.org/10.4103/2229-4708.72222.

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