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Dissertations / Theses on the topic 'SOX6, Cell differentiation'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

BARBARANI, GLORIA. "The transcription factor Sox6 induces differentiation and cell cycle withdrawal in BCR-ABL+ and JAK2 V617F+ cellular model systems of leukemia." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/113929.

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SOX6 is a transcription factor (TF) belonging to the Sry-related HMG-box TFs family. It controls terminal differentiation and lineage specification of many cell types, by mediating cell cycle withdrawal and activation of lineage specific genes. In hematopoiesis, Sox6 sustains cell survival, proliferation and terminal maturation of murine erythroid cells. To explore the role of SOX6 in human erythropoiesis, we first overexpressed it in erythroleukemic BCR-ABL+ K562 cell line. In these cells, Sox6 overexpression induces a strong erythroid differentiation coupled with growth arrest. This last ef

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2

Moleri, S. "Sox18 and Sox7 play redundant roles in endothelial cell differentiation." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/56632.

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The main focus of our laboratory is clarifying the roles of DNA binding proteins belonging to the HMG box superfamily during embryonic development. In particular, I studied Sox18 and Sox7 in zebrafish and our data show that they act redundantly in vascular development. Mutations in SOX18 have been associated with Hypotrichosis-Lymphedema-Telangiectasia (HLT), a human syndrome combining defects in hair follicle, blood and lymphatic vessels development. Similarly, spontaneous mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice, including symptoms of lymphatic dysf

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3

Stavridis, Marios Pericles. "Construction and use of a Sox1 reporter cell line to study embryonic stem cell differentiation." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/14484.

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<i>Sox1</i> is upregulated during ES cell differentiation into neural precursors, and its misexpression causes an EC cell line to differentiate into neurons. <i>Sox1 </i>expression during nervous system development is associated with proliferating cells of the CNS, expression being lost as cells exist mitosis and terminally differentiate. Its expression pattern is more restricted than that of most other markers for early neural cells such as nestin, making it a good marker gene for the study of neural development both <i>in vivo</i> and <i>in vitro</i> from ES cells. Here I have used gene targ

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4

Okolicsanyi, Rachel K. "Mesenchymal stem cells as mediators of the neuronal cell niche." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84485/1/Rachel_Okolicsanyi_Thesis.pdf.

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This study examined the role of heparan sulfate proteoglycans (HSPGs) in neural lineage differentiation of human mesenchymal stem cells (hMSCs). Several HSPGs were identified as potential new targets controlling neural fate specification and may be applied to the development of improved models to examine and repair brain damage. hMSCs were characterised throughout extended in vitro expansion for neural lineage potential (neurons, astrocytes, oligodendrocytes) and differentiated using terminal differentiation and intermediate sphere formation. Brain damage and neurological disorders caused by i

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5

Ghanem, A. M. "Molecular regulation of Sox2 expression during differentiation of chick embryonic stem cells." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/133262/.

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The transcription factor Sox2 has a key role not only in maintaining stem state but also in specification of neural fate of embryonic cells. Multiple regulatory elements have been identified in the Sox2 locus (Uchikawa et al, 2003). In the developing embryo, these regulatory elements are activated differentially in time and space. We studied the activity of 25 defined regulatory elements of the Sox2 promoter in three different lines of chick ES cells. By transfection of plasmids encoding Enhanced Green Fluorescent Protein (EGFP) and the minimal promoter thymidine kinase (tk) coupled with indiv

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6

Yagi, Rieko. "Bcl-2 Regulates Chondrocyte Phenotype Through MEK-ERK1/2 Pathway; Relevance to Osteoarthritis and Cartilage Biology." [Kent, Ohio] : Kent State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1118329494.

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Thesis (Ph.D.)--Kent State University, 2005.<br>Title from PDF t.p. (viewed Sept. 5, 2006). Advisor: Walter E. Horton. Keywords: chondrocytes; osteoarthritis; Sox9; Bcl-2; MEK-ERK 1/2. Includes bibliographical references (p. 91-106).

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7

MARIANI, JESSICA. "Transcriptional regulation, target genes and functional roles of the SOX2 transcription factor in mouse neural stem cells maintenance and neuronal differentiation." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/8321.

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The aims of this PhD research were: to examine molecular mechanisms underlying the transcriptional regulation of the Sox2 gene during forebrain development; to examine the role of Sox2 for the proper neuronal differentiation of neural stem cells; and to examine the role of Sox2 in controlling the maintenance of neural stem cells (in vivo and in vitro). The aim of the first work (Chapter 1) was to investigate the transcription factors and the regulatory sequences that control transcription of the Sox2 gene in the developing brain and neural stem cells. Our laboratory previously identified Sox2

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8

Kimura, Yoshito. "ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice." Kyoto University, 2018. http://hdl.handle.net/2433/235986.

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9

Al-Asaad, Imane. "Étude de marqueurs de différenciation testiculaire Sox9 et Amh lors d'un développement normal, d'une inversion sexuelle et d'un développement en absence de cellules germinales chez l'amphibien urodèle Pleurodeles waltl. Intérêt pour la physiologie comparée de la reproduction des vertébrés." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0229/document.

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Dans le contexte de la physiologie comparée de la reproduction, les amphibiens sont peu étudiés. Le travail réalisé durant cette thèse visait à analyser des marqueurs de différenciation testiculaire chez l'urodèle Pleurodeles waltl, dont le déterminisme génétique du sexe (ZZ/ZW) peut être influencé par la température. Nos études ont d'abord porté sur le gène sox9 marqueur de la différenciation testiculaire chez les vertébrés supérieurs. Le gène cloné chez le pleurodèle montre une bonne conservation par rapport aux autres vertébrés. Son expression plus élevée dans la gonade mâle n'apparaît que

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10

Kaur, Navdeep. "Influence of culture conditions on the molecular signature of mesenchymal stem cells." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/43719/1/Navdeep_Kaur_Thesis.pdf.

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Cell based therapies require cells capable of self renewal and differentiation, and a prerequisite is the ability to prepare an effective dose of ex vivo expanded cells for autologous transplants. The in vivo identification of a source of physiologically relevant cell types suitable for cell therapies is therefore an integral part of tissue engineering. Bone marrow is the most easily accessible source of mesenchymal stem cells (MSCs), and harbours two distinct populations of adult stem cells; namely hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs). Unlike HSCs, there ar

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11

Leménager, Hélène. "Mécanismes moléculaires et cellulaires des processus de différenciation et de plasticité cellulaire pour la formation des adipocytes." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30227.

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Les adipocytes sont les unités fonctionnelles du tissu adipeux (TA). Les adipocytes blancs du TA blanc assurent le stockage et la libération de l'énergie au sein de l'organisme, principalement sous forme d'acides gras1. A l'opposé, les adipocytes bruns du TA brun ont une grande capacité à consommer les acides gras par l'activité de la protéine UnCoupling Protein 1 (UCP1)2. Enfin, il a été observé des adipocytes UCP1+ dans le TA blanc, notamment en réponse à une exposition au froid3. Ces adipocytes sont appelés adipocytes beiges et sont issus de deux processus : d'une part via l'adipogenèse à p

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12

Humphrey, Peter Saah. "Signal transduction mechanisms for stem cell differentation into cardiomyocytes." Thesis, University of Hertfordshire, 2009. http://hdl.handle.net/2299/3760.

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Cardiovascular diseases are among the leading causes of death worldwide and particularly in the developed World. The search for new therapeutic approaches for improving the functions of the damaged heart is therefore a critical endeavour. Myocardial infarction, which can lead to heart failure, is associated with irreversible loss of functional cardiomyocytes. The loss of cardiomyocytes poses a major difficulty for treating the damaged heart since terminally differentiated cardiomyocytes have very limited regeneration potential. Currently, the only effective treatment for severe heart failure i

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13

Yang, Pao-Ying, and 楊寶英. "The role of Sox1 gene in neural differentiation of Human Embryonic Stem cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/25213038503313178533.

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碩士<br>國立臺灣海洋大學<br>生物科技研究所<br>96<br>The generation of functional neuronal subtypes in the vertebrate central nervous system involves several steps. Early vertebrate neural development started from epiblast which is the pluripotent descendents of inner cell mass(ICM) of the blastocyst. The epiblast cells give rise to three embryonic germ layers(ectoderm,mesoderm and endoderm). Subsequently, ectodermal precursors forms early neuroepithelium containing very early neural stem cells. Then, neuroectoderm forms the neural plate and neural tube which become the source of the central nervous system. Re

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14

Lin, Chen-Yu, and 林真宇. "In vivo survival and differentiation of Sox1 expressing neural progenitors derived from embryonic stem cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/27910382453605803232.

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碩士<br>國立臺灣海洋大學<br>生物科技研究所<br>95<br>Abstract Sox1 is one of the earliest transcription factors expressing in embryonic neuroepithelial cells and its expression correlates with the formation of the neural tube during early development. Additionally, it was demonstrated that Sox1 also expressing in the proliferating neural progenitors of both embryonic telencephalon and adult lateral ventricle at which active neurogenesis is evident. Taken together, these data indicate that Sox1 expressing cells may persistently contribute to neurogenesis from early development to adulthood. Sox1 is the earliest

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15

Lee, Chih-Chan, and 李志展. "Sox2, an EGFR induced transcriptional factor, modulates cell growth and mesenchymal-epithelial trans-differentiation (MET) of lung cancer." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/91356858696672476371.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>98<br>Aberrant expression and function of epidermal growth factor receptor (EGFR) is reported in most lung cancer cases. Sox2, a core transcription factor regulating self-renewal of stem cells, is highly expressed in lung cancer. We discovered that EGFR and its ligands (TGF-??nand EGF) induce Sox2 expression in lung cancer. Ectopic expression of c-Myc, a key effector of EGFR signaling, induced Sox2 expression; knockdown of c-Myc decreased Sox2 level in lung cancer, suggesting that EGFR induces Sox2 via a c-Myc dependent pathway. Ectopic expression of Sox2 promoted

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