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Relevant bibliographies by topics / STEM-platform / Dissertations / Theses

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Dissertations / Theses on the topic 'STEM-platform'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Chin, Vicki I. "A microfabricated platform for cell-based assays : applications to neural stem cells /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3153701.

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2

Moens, N. C. H. "Expansion and differentiation of human embryonic stem cells on an automated microwell platform." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1433001/.

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Human embryonic stem cells (hESCs) have the potential to provide a limitless supply of somatic cells that can find application in regenerative medicine and drug discovery. Having a scalable and cost-effective manufacturing process for the expansion and maintenance of hESCs is essential to achieving this potential. As hESC culture is currently a largely manual process, major challenges in the methods used concern variability and scalability. In this case bioprocess automation can be of benefit to reduce operator-dependent variation, therefore improving cell yield and quality, and enabling scale

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Naranjo, Santiago(Santiago Jose). "An organoid platform to study alveolar stem cells in lung generation and cancer." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/129032.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2020<br>Cataloged from student-submitted PDF of thesis. Vita.<br>Includes bibliographical references.<br>Lung adenocarcinoma (LADC) remains the most common and lethal cancer type worldwide. Although recent breakthroughs using a new class of immune-modulatory therapeutics have improved patient survival in the clinic, the majority still invariably succumb to this disease, highlighting the importance of improving treatment strategies. A wide variety of models have been developed to study LADC. Cell line- and transplant-

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Lucarelli, Enrico <1962&gt. "Mesenchymal Stem Cells as a Delivery Platform for Photoactivable Nanoparticles for Cancer Therapy." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/7909/25/Lucarelli_Enrico_Tesi.pdf.

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Osteosarcoma patients are treated with the combination of multi-agent chemotherapy and surgery. With this treatment the 5-year event free survival of non-metastatic OS patients is 70% and between 20-25% of the OS patients with metastasis. This could be explained in part because chemotherapy is not selective for tumor cells, in part because micrometastasis are difficult to detect. In order to improve patient’s survival rate, innovative treatments that specifically find and target osteosarcoma cells should be developed. The aim of this PhD thesis is test an innovative strategy to be used as neod

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Müller, Eike, Weijia Wang, Wenlian Qiao, et al. "Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-208979.

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Homeostasis of hematopoietic stem cells (HSC) in the mammalian bone marrow stem cell niche is regulated by signals of the local microenvironment. Besides juxtacrine, endocrine and metabolic cues, paracrine and autocrine signals are involved in controlling quiescence, proliferation and differentiation of HSC with strong implications on expansion and differentiation ex vivo as well as in vivo transplantation. Towards this aim, a cell culture analysis on a polymer microcavity carrier platform was combined with a partial least square analysis of a mechanistic model of cell proliferation. We could

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Ahmad, Faizzan Syed. "A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:17972018-6750-4e5c-8cc9-42e9c381f531.

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Scientific research is propelled by two objectives: Understanding and recognizing the essential biology of life, and deciphering this to uncover possible therapeutics in order to improve quality of life as well as relieve pain from disease. The aim of the work described in this thesis was to dissect the fundamental requirements of induced pluripotent stem cells both in pluripotency and differentiation with a particular focus on atrial specificity. Drug targeting of atrial-specific ion channels has been difficult because of lack of availability of appropriate cardiac cells, and preclinical test

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Marco, Giménez Andrés 1993. "Generation and validation of a CRISPR platform for rapid and inducible genome editing in human pluripotent stem cells and kidney organoids." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673798.

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Our current knowledge about the function of human genes is mostly based on data from genetic studies using animal models. However, divergence among species may hamper the understanding of genetic mechanisms underlying human specific traits. Nowadays, an alternative to animal models stands on the generation of organ-like cultures derived from human pluripotent stem cells (hPSCs), the so called organoids. In the last years, the organoids have proved to recapitulate, in a high extent, the development, multicellular architecture, and physiology of human organs. To perform genetic studies in

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8

Plumbly, William. "The creation of a platform for investigating the network function of human pluripotent stem cell derived neurons in development and disease." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/111225/.

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The formation and function of neural networks is a key aspect of normal brain development, while a converging body of evidence from human genetic and clinical/preclinical studies strongly implicates altered synapse and network function in the aetiology of mental health disorders, including autism spectrum disorder (ASD). The advent of induced pluripotent stem cells (iPS cells) and protocols to differentiate them into functional neurons provides exciting opportunities for modelling human development and disease in vitro, although until recently the possibilities for investigating network functi

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Tronser, Tina [Verfasser], and Dr P. [Akademischer Betreuer] Levkin. "Investigation of mouse embryonic stem cell pluripotency using a miniaturized platform for high-throughput screenings in 2D or 3D / Tina Tronser ; Betreuer: Dr. P. Levkin." Karlsruhe : KIT-Bibliothek, 2018. http://d-nb.info/1174992204/34.

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10

Khan, Kafaitullah [Verfasser], and Toni [Akademischer Betreuer] Cathomen. "Establishing a zinc finger nuclease platform for targeted genome editing in human cell lines, primary keratinocyte stem cells and cardiomyocytes in vivo / Kafaitullah Khan. Hannover Medical School Institute of Experimental Hematology. Betreuer: Toni Cathomen." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2012. http://d-nb.info/1028165080/34.

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11

Khan, Kafaitullah [Verfasser], and Anton [Akademischer Betreuer] Cathomen. "Establishing a zinc finger nuclease platform for targeted genome editing in human cell lines, primary keratinocyte stem cells and cardiomyocytes in vivo / Kafaitullah Khan. Hannover Medical School Institute of Experimental Hematology. Betreuer: Toni Cathomen." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2012. http://nbn-resolving.de/urn:nbn:de:gbv:354-20120803129.

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12

Sanchez, Herrero Alvaro. "Tissue engineering of an orthotopic humanised bone-organ as a platform for preclinical multiple myeloma research." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/203046/1/Alvaro_Sanchez%20Herrero_Thesis.pdf.

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This Thesis presents the first steps of the development of a humanized and patient-specific mouse model of multiple myeloma (MM). Novel therapeutic approaches are getting increasingly complex and relevant pre-clinical drug testing is becoming a great challenge. The mouse model presented here features a humanized bone marrow compartment with a humanized bone shell that is able to engraft MM cells and patient-derived hematopoietic stem cells, mimicking myeloma bone disease serving as a unique platform for MM drug testing and discovery.

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13

Monterosso, Melissa Eileen. "The Microwell-mesh platform: A multifaceted microtissue technology to link cell culture, animal models and patients." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/236375/1/Melissa_Monterosso_Thesis.pdf.

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Work towards effective translational medicine has revealed that current in vitro platforms are not sufficient to produce relevant clinical results. Advances in 3D technologies and preclinical models must be made to address the gaps lead to failure of initially promising therapies. The Microwell-mesh platform is a versatile device demonstrated to help bridge this gap. The device within the context of completed work was used to not only generate cancer xenograft models, crucial for successful personalized cancer therapeutics, but was also used to investigate the capacity of adult mesenchymal ste

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Reichert, Verena Maria Charlotte. "Application of a human bone engineering platform to an in vitro and in vivo breast cancer metastasis model." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/53212/1/Verena_Reichert_Thesis.pdf.

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Breast cancer in its advanced stage has a high predilection to the skeleton. Currently, treatment options of breast cancer-related bone metastasis are restricted to only palliative therapeutic modalities. This is due to the fact that mechanisms regarding the breast cancer celI-bone colonisation as well as the interactions of breast cancer cells with the bone microenvironment are not fully understood, yet. This might be explained through a lack of appropriate in vitro and in vivo models that are currently addressing the above mentioned issue. Hence the hypothesis that the translation of a bo

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15

Hsieh, Tsung-Han, and 謝宗翰. "Study on the Platform Development of Induced Pluripotent Stem Cell." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/54376103939928103673.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>101<br>Induced pluripotent stem cells (iPSCs) were derived from somatic cells that have been induced to reprogram, which offered an appealing solution to the likely immune rejection of ESC-derived cells, thus providing newer and safer avenues for patient-specific cell therapy. However, there are two main hurdles in iPSCs applications. First is the efficiency of reprogramming is extremely low. And although many research groups have shown some strategies to enhance the reprogramming efficiency, the results remain unsatisfied. The other hurdle is the tumorigenicity of i

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Chen, Kuan-Hsuan, and 陳寬軒. "Testing and Application Oxidative Stress on Induced Pluripotent Stem Cell (iPSC) Platform." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/80581943014322361930.

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博士<br>國立陽明大學<br>臨床醫學研究所<br>104<br>In 2006, Shinya Yamanaka discovered four genes Oct3/4, Sox2, Klf4, c-Myc that can successfully reprogram somatic cells into a pluripotent stem cells (Induced pluripotent Stem Cells, iPSCs). Employment of iPSCs as in vitro experiment platform does not need to isolate stem cells from the embryo and therefore can be carried out without the conventional ethical issues. Another advantage of such platform is that the somatic cells for cell reprogramming can be obtained directly from the patients’ skin and prevent the possibility of immune rejection. It has been rep

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17

Cheng, Chi-An, and 程吉安. "Fluorescent Nanodiamond as a Biocompatible Nanoparticle Platform and its Application for Long-Term Stem Cell Tracking and In Vivo Lung Stem Cell Sorting." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/04327715915749010432.

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碩士<br>國立臺灣大學<br>化學研究所<br>99<br>Fluorescent nanodiamond (FND) is a sp3-carbon-based nanomaterial produced by radiation-damage followed by annealing. FND possess several unique properties such as excellent biocompatibility, facile surface modification, high tissue-penetrable red fluorescence and outstanding photostability, making it well suited for long-term labeling and tracking of cells. In this study, we use surface-oxidized FND particles (size~100nm) as the cell tracker. We introduce FNDs into cells by endocytosis through incubation, and do flow cytometric analysis. Based on different cell t

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18

Chen, Fu-Yao, and 陳扶瑤. "Establishment of Human Dental Pulp Derived Induced Pluripotent Stem Cells as a Platform of Personal Medicine." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/13067836107950466009.

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碩士<br>國防醫學院<br>生物及解剖學研究所<br>101<br>The organogenesis of tooth starts with the thickening of oral epithelium. Subsequent to the increase in thickness, oral epithelial cells initiate the reciprocal signaling with the underlying ectomesenchyme. The epithelial cells differentiate into ameloblasts to form enamel while the ectomesenchymal cells differentiate into other cells to form the remaining tooth structures. However, the regeneration of enamel is still not feasible because the enamel epithelium is degenerated once the enamel formation is completed and leaves no ameloblasts in situ for further

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19

Chen, Sheng-Mei, and 陳聖美. "The role of canonical Wnt signals in a novel platform for neural induction from pluripotent stem cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/47393999425878542834.

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博士<br>國立中興大學<br>生命科學系所<br>102<br>Establishing an efficient differentiation procedure is prerequisite for the cell transplantation of pluripotent stem cells. Activating fibroblast growth factor (FGF) signals and inhibiting activin/nodal pathway are both conserved principles to direct the neural induction (NI) of developing embryos and human embryonic stem cells (hESCs). Wnt signal and Oct4 expression are critical for the hESC pluripotency, however, their roles in cell differentiation are largely unclear. We demonstrate that in the presence of FGF2 and activin inhibitor SB431542, applying a smal

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20

Matias, Dino Emanuel Santos. "Human neurons derived from induced pluripotent stem cells: a platform for screening compounds to treat Gaucher´s disease and Parkinson's disease." Doctoral thesis, 2020. http://hdl.handle.net/10400.1/16730.

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A doença de Gaucher (Gaucher disease – GD) é a doença lisossomal com maior taxa incidência em todo o mundo (Mistry et al., 2017). As doenças de armazenamento lisossomal, são um grupo de doenças metabólicas hereditárias caracterizadas pela redução de atividade ao longo de uma via metabólica, levando à acumulação de um ou mais dos seus substratos, e consequente desregulação celular. GD é causada por níveis reduzidos de atividade da hidrolase β-glucocerebrosidase (GCase), o que pode ocorrer por mutações no centro ativo, alterações no processamento, no ativador ou nos transportadores. A doe

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21

Luu, Rebeccah. "Engineered platform to generate 3D cardiac tissues for modeling genetic cardiomyopathies." Thesis, 2018. https://hdl.handle.net/2144/30731.

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Studies to gain mechanistic understanding of heart dysfunction based on animal and traditional cell culture models have significant limitations. Animal models are low throughput and fail to recapitulate many aspects of human cardiac biology, and 2D culture models utilizing human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) are higher throughput but fail to incorporate one or more in vivo parameters, such as 3D architecture, electrical pacing and mechanical constraint. High throughput 3D tissue platforms could better recapitulate the in vivo microenvironment of cardiac tissue

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