Academic literature on the topic 'Stephen Watts'

Organoids are developed from stem cells and serve as three-dimensional model systems for different organs. They have great potential for research and medicine, but also raise philosophical, ethical and legal questions which have rarely been discussed in Germany so far. This thematic study by the interdisciplinary research group (IAG) Gene Technology Report at the Berlin-Brandenburg Academy of Sciences and Humanities offers an overview of current scientific developments, their present and potential application, as well as epistemological, ethical and legal reflections. Hereby, the IAG wants to provide impetus for an interdisciplinary and society-wide debate on this general subject. With contributions by Cantas Alev, Aileen-Diane Bamford, Sina Bartfeld, Andreia S. Batista-Rocha, Ali H. Brivanlou, Thomas Burgold, Cindrilla Chumduri, Stephan Clemens, Emrecan Dilmen, Tobias Erb, Fred Etoc, Melinda B. Fagan, Heiner Fangerau, Boris Fehse, Nina Frey, Tristan Frum, Anne Grapin-Botton, Navin Gupta, Jürgen Hampel, Ferdinand Hucho, Özge Kayisoglu, Rashmiparvathi Keshara, Yung Hae Kim, Bon-Kyoung Koo, Martin Korte, Yaroslav Koshelev, Kai Kretzschmar, Allison Lewis, Lilian Marx-Stölting, Fruzsina Molnár-Gábor, Ryuji Morizane, Stefan Mundlos, Paola Nicolas, Angela Osterheider, In-Hyun Park, Anja Pichl, Sandra Pilat-Carotta, Jens Reich, Marlen Reinschke, Hannah Schickl, Silke Schicktanz, Nicolas Schlegel, Jason R. Spence, Yoshiaki Tanaka, Jochen Taupitz, Isaree Teriyapirom, Margherita Y. Turco, Jörn Walter, Eva Winkler, Martin Zenke.

Stephen Smith wants you to hear history. He’s made excellent work across a broad spectrum. He produced an aural portrait of the playwright August Wilson; he uncovered war crimes in Kosovo. Some of his best docs, and those he most loves to make, explore twentieth-century history. Stephen traces the short life story of recorded sound, this magic we take for granted. And through his own pieces, like “Song Catcher, Frances Densmore of Red Wing”; “Remembering Jim Crow”; and “White House Tapes: The President Calling,” Stephen shows how radio can blast us into another time, “past the rope-line of textbook history.”

Interview with Professor John Rorke, Technical Assistant to the Engineering Director, Stephen, Linthouse, Engineering Director, Denny Brothers, Dumbarton, Chairman, Brown Brothers, Edinburgh, Vice Principal, Heriot Watt University, Edinburgh. Details experience working on the Upper Clyde.

For a review of a monograph by C. Wiles and P. Watts on applications of flow reactors in organic synthesis, see Org. Process. Res. Dev. 2011, 15, 947. For a review by Klavs S. Jensen of MIT of flow approaches, see Angew. Chem. Int. Ed. 2011, 50, 7502. Hans-René Bjørsvik of the University of Bergen described (Org. Process. Res. Dev. 2011, 15, 997) a multijet oscillating disc microreactor, and Andreas Schmid of the Technische Universität Dortmund (Adv. Synth. Catal. 2011, 353, 2511) and László Poppe of the Budapest University of Technology and Economics discussed (Adv. Synth. Catal. 2011, 353, 2481) continuous flow reactors for biotransformations. Gases are readily handled in a flow apparatus. S. Chandrasekhar of the Indian Institute of Chemical Technology, Hyderabad demonstrated (Tetrahedron Lett. 2011, 52, 3865) partial deuteration of 1 to 2, using D2O as the deuterium source. Peter H. Seeberger of the Max Planck Institute, Potsdam oxidized (Org. Lett. 2011, 13, 5008) 3 to 4 with singlet oxygen. Dong-Pyo Kim of Chungnam National University and Robert H. Grubbs of Caltech effected (Org. Lett. 2011, 13, 2398) ethenolysis of 5 to give 6 and 7. Takashi Takahashi of the Tokyo Institute of Technology showed (Chem. Commun. 2011, 47, 12661) that even phosgene could be handled in a flow system, using it to activate 8 for condensation with benzylamine to give 9. In the liquid phase, Stephen L. Buchwald of MIT prepared (Angew. Chem. Int. Ed. 2011, 50, 8900) 11 by the fluorination of 10. Jesús Alcázar of Janssen Pharmaceutical, Toledo, showed (Tetrahedron Lett. 2011, 52, 6058) that a nitrile 12 could be reduced in a flow system to the aldehyde 13. Mark York of CSIRO prepared (Tetrahedron Lett. 2011, 52, 6267) the furan 16 by condensation of 14 with 15. Floris P.J.T. Rutjes of Radboud University Nijmegen used (Org. Process Res. Dev. 2011, 15, 783) the careful controls of a flow reactor to optimize the exothermic combination of 17 with 18 to give 19. Professor Buchwald demonstrated (Angew. Chem. Int. Ed. 2011, 50, 10665) a flow protocol for the lithiation of 20 with in situ borylation and Pd-catalyzed coupling with 21 to give 22.

Simulation modeling is a complementary tool to field observation and experimentation in understanding ecological systems (Lauenroth et a l., 1998). The overall objective of our plant community modeling is to allow us to evaluate the importance of gap dynamics concepts of succession for understanding shortgrass plant community recovery after disturbances. A gap dynamics approach focuses on individual plants, and the interactions between disturbance characteristics and plant life history traits in explaining successional patterns (Watt, 1947). Simulation models have been used extensively to evaluate the importance of gap dynamics processes to short- and long-term vegetation dynamics in temperate and tropical forests (e.g., Botkin et al., 1972; Shugart, 1984). We developed a gap dynamics model for shortgrass steppe plant communities (STEPPE [Coffin and Lauenroth, 1990]) based upon the conceptual and modeling framework provided by forest models, modifying it to represent Great Plains grasslands (Coffin and Lauenroth, 1996; Coffin and Urban, 1993). We used STEPPE in several capacities: (1) to synthesize and integrate existing knowledge to improve our understanding of recovery processes after disturbance, (2) to identify key processes limiting recovery, and (3) to predict long-term recovery dynamics for different climate and disturbance characteristics—in particular, soil texture and disturbance size. Our approach to modeling shortgrass community dynamics was to incorporate only the most important processes needed to address specific research questions. We added processes through time either because the model did not sufficiently represent ecosystem dynamics or because we posed more complicated research questions. STEPPE simulates the recruitment, growth, and mortality of individual plants on a small plot through time at an annual time step (Fig. 7.1) (Coffin and Lauenroth, 1990). Recruitment and mortality both have stochastic elements. Growth is deterministic and is based upon competition for resources among plants. A key difference between STEPPE and the forest models from which it was derived is that belowground resources are the most frequently limiting resources in semiarid grasslands compared with aboveground resources (light) in forests (Lauenroth and Coffin, 1992).

The impact of cloudiness on the global radiative budget and its climatic consequences have been widely discussed during the last three decades. It was gradually recognized that the climatic effect of cloudiness depends on its height: low- and middle-level cloudiness have a total cooling effect on the Earth climatic system, while the upper-level clouds, cirrus, may have mostly a warming effect (IPCC 1995). The net effect of cirrus (i.e., warming or cooling), is much less clear because neither their microphysical and optical properties, nor the processes that govern their formation, are well understood and parameterized in climate models. These uncertainties have stimulated several major field projects performed within the International Satellite Cloud Climatology Project (ISCCP; Rossow and Schiffer 1991) with subsequent data analysis reports [e.g., FIRE IFO-I (1990), FIRE IFO-II (1995), and EUCREX (Raschke et al. 1996)]. The relevant theoretical works, and even the simplest climate models, indicate that the climatic impact of cirrus depends on their microstructure: clouds composed of small crystals with effective radii less than about 16 μm have a total cooling effect, but clouds of larger crystals have a warming effect (Stephens et al. 1990). It was shown that the total cloud forcing at the top of the atmosphere (TOA) is positive from a few to a few tens of watts per square meter for the large crystals and decreases with decreasing crystal radius (Fu and Liou 1993). Most of the previous theoretical studies of cirrus radiative properties, after choosing some model of microphysics and some values for the mass extinction and absorption coefficients, then prescribed them to the whole cloud, neglecting any vertical variations. Simulations with general circulation models (GCMs) showed that cirrus clouds with their optical properties parameterized in such a way (i.e., constant with height) have a total warming effect and positive feedbacks with respect to greenhouse gas-induced global warming (e.g., Ramanathan et al. 1983; Wetherald and Manabe 1988). Today, the estimation of the warming/cooling effect of cirrus has become even more complicated due to two factors. First, for many years the usual in situ probes allowed the measurement of ice crystals with radii only larger than 25-50 μm, so the smallest and most optically and radiatively active crystals were unresolved.