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Dissertations / Theses on the topic 'Structure elucidation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Li, Guoqiang. "Structure elucidation of bioactive natural products." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/NQ29469.pdf.

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2

Thistlethwaite, Iain R. G. "Structure elucidation of the kalimantacin antibiotics." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685333.

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In this thesis the production, isolation and purification of the kalimantacin antibiotics are described along with details of the elucidation of the structures including the relative and absolute stereochemistry. Kalimantacin A, isolated from Pseudomonas jluorescens strain BCCM_ ID9359, is biosynthesised by a trans-AT type I polyketide synthase (PKS) and exhibits strong and selective activity against multi-resistant Staphylococcus aureus (MRSA). Two mutant strains, ~batF and ~batM, have been produced from which 17- hydroxy analogue 20, 27-descarbamoyl analogue 21 and 17-hydroxy-27-descarbamoyl

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3

施麗琼 and Lai-king Sy. "Structure elucidation and oxidation chemistry of natural products." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B3123768X.

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4

Murphy, Annabel Christine. "Structure Elucidation and Synthesis of Natural Products." Thesis, University of Canterbury. Chemistry, 2008. http://hdl.handle.net/10092/1748.

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In this thesis, synthetic chemistry was used as a tool in the exploration of various aspects of natural products discovered by the natural products research group at the University of Canterbury. Work on the constituent amino acids and connectivity of the pteratides, a potently cytotoxic series of cyclodepsipeptides, had been completed before the beginning of this work (carried out by Miss C. Chen). The elucidation of the stereochemistry of the constituent amino acids was undertaken in this present work. The synthesis of all stereochemical entities of a number of unusual amino acids, which wer

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5

Chatterjee, Ashraf Anne Kublawi. "Structure elucidation of biopolymers by mass spectrometry." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/47800.

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6

Abildgaard, Jens. "Quantum chemical models in molecular structure elucidation /." Roskilde : Roskilde University, Department of Life Sciences and Chemistry, 1998. http://hdl.handle.net/1800/535.

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7

Buchanan, H. J. "The synthesis and structure elucidation of organotin-steroids." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592189.

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The thesis was concerned with the synthesis structures and activity and reactivities of stannylated steroid derivatives. Most attention has been paid to cholesterol and cholestene derivatives. Directly bonded stannylated cholestene derivatives have been obtained by various routes. 3α-triphenylstannylcholest-5-ene was obtained from the regiospecific reaction of Ph<SUB>3</SUB>SnLi with cholesteryl sulphonates; 3β-triorganostannylcholest-5-ene was obtained by the regiospecific reaction of Ph<SUB>3</SUB>SnCl with 3β-chloromagnesiocholest-5-ene. The Barbieri-type reaction of Ph<SUB>3</SUB>SnCl and

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8

Chan, Anna Leung. "The structure elucidation of glycoproteins by mass spectrometry." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46703.

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9

Tatolo, Godiraone. "Improved NMR-based methods for molecular structure elucidation." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680109.

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The use of 1H_I3C NMR correlations and its corresponding I1JCH has found a tremendous use in structural elucidation of organic compounds. Chapter 1 highlights different methods for determination of IH_13C correlations and for the measurement of I1JCH. In this work we reported two improved methods for determination of IH_I3C correlations (CTgc2HMBC) and, for the measurement of nJCH (SelEXSIDE). Chapter 2 describes the work undeliaken in order to quantify improvements to the gradient heteronuclear multiple bond correlation (HMBC) experiment specifically to design a constant time gradient HMBC (C

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10

Sy, Lai-king. "Structure elucidation and oxidation chemistry of natural products /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19737300.

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11

Fotso, Joseph. "Structure elucidation and toxicological characterization of Fusarium metabolites /." Search for this dissertation online, 2003. http://wwwlib.umi.com/cr/ksu/main.

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12

Daoust, Julie. "Isolation and structure elucidation of bioactive marine natural products." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/37536.

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Clionamines A-D (2.6-2.9) are new aminosteroids isolated from South African specimens of the sponge Cliona celata. All four compounds (2.6-2.9) are activators of autophagy in MCF-7 cells. Autophagy is a catabolic process that plays an important role in maintaining cellular homeostasis. Autophagy is also directly involved in the removal of bacterial and viral antigens and in the development of cancerous tumors. The novel sesterterpenoid ansellone A (3.4) was isolated from the nudibranch Cadlina luteomarginata and was later found to have been sequestered by the nudibranch from the sponge Phorbas

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13

Song, Yang. "Protein Primary and Quaternary Structure Elucidation by Mass Spectrometry." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437649750.

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14

Picheansoonthon, Chayan. "Isolation and structure elucidation of terpenoids from Simsia spp /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487670346875004.

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15

Bull, Freya Margaret. "Structure elucidation and synthetic studies on the kalimantacin antibiotics." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707731.

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16

Madland, Eva. "Extraction, Isolation and Structure Elucidation of Saponins from Herniaria incana." Thesis, Norges Teknisk-Naturvitenskaplige Universitet, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-20446.

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Species of the Herniaria genus have been reported to have several medicinal uses. Two of the species from this genus, Herniaria glabra and Herniaria hirsuta, have both been documented to contain saponins. This can explain the health benecial use of these plantspecies, since saponins are known for their many biological properties. However, the lack of information on one of their relatives, Herniaria incana, makes this species a target for further investigation.The aim of this master thesis is to determine the total saponin contentof H. incana, as well as to extract, isolate and closely investig

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17

Forestieri, Roberto. "Isolation, structure elucidation, and total synthesis of bioactive natural products." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45668.

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18

Godavarti, Ranganathan S. "Protein engineering of Heparinase I : elucidation of structure-activity relationships." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/40208.

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19

Murphy, Brian Thacher. "Isolation and Structure Elucidation of Antiproliferative Natural Products from Madagascar." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/29599.

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As part of an ongoing search for bioactive natural products from the endemic rainforests and surrounding ocean in Madagascar, a total of four extracts were comprehensively studied and were found to contain novel and/or bioactive compounds. The following dissertation discusses the isolation, structure elucidation, and bioactivity studies of these isolates. The following compounds from plants of Madagascar's rainforest are discussed in the order they were studied: flavonoids and long-chain compounds from Schizolaena hystrix, a cyclohexene derivative and butenolides from Artabotrys madagascar

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20

Karkare, Sampada S. "Isolation and Structure Elucidation of Antiproliferative Agents From Madagascar Rainforests." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/34945.

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Through our continuing search for anticancer agents from Madagascar rainforests as a part of International Cooperative Biodiversity Group (ICBG), we received two extracts which were active against the A2780 human ovarian cancer cell line and hence were selected for further fractionation. Six compounds were isolated from these extracts. The structure elucidation and characterization of these compounds was carried out using mass spectrometry and 1D and 2D NMR techniques. The bioassay-guided fractionation of Roupellina (Strophanthus) boivinii yielded three new and one known cardenolide glycoside

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21

Su, Qingxi. "Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/72954.

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As part of an International Cooperative Biodiversity Group (ICBG) program and a collaborative research project with the Natural Products Discovery Institute, twenty plant extracts were investigated for their antiproliferative and antimalarial activities. Bioassay guided fractionation of thirteen extracts led to the identification of three new antiproliferative compounds, ethyl leptaulosides A-C (5.1-5.3), six new antiplasmodial compounds, apoplanesiacarpan A and B (2.4-2.5), (±)-rhodomyrtosone F (3.1), (±)-calliviminone C (3.2), 3α-angeloyloxy-15-hydroxylabda-7,13-dien-16,15-olid-18-oic acid (

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22

Liu, Yixi. "Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/52259.

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As part of an International Cooperative Biodiversity Group (ICBG) program and a continuing search for antiproliferative natural products from the Madagascar rainforest, and a collaborative research project established between Virginia Tech and the Institute for Hepatitis and Virus Research (IHVR) focusing on searching for bioactive natural products from tropical forests in South Africa, 20 extracts were selected for investigation based on their antiproliferative activities against A2780 human ovarian cancer cell line or antimalarial activities against the Dd2 strain of Plasmodium falciparum. B

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23

Tsiao, Candy. "Approaches to intermolecular structure elucidation utilizing NMR and DNP parameters." Diss., Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/54441.

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This thesis is divided into two parts. The first part involves the study of molecular structure utilizing Ianthanide induced shift (LIS) and lanthanide induced relaxation (LIR) nuclear magnetic resonance (NMR). It the course of these studies, it was found that the trifluoroethoxy group is a good deactivating group towards lanthanide shift reagents (LSR) and can be used to selectively deactivate multifunctional molecules. The second part of the thesis involves the utilization of liquid-liquid intermolecular transfer (LLIT) dynamic nuclear polarization (DNP) to study the microwave power needed

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24

Biehle, Susan J. "SPECTROSCOPIC STUDIES OF ORGANIC AND BIOLOGICAL SYSTEMS." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin989423359.

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25

Liu, Yang [Verfasser]. "Isolation and Structure Elucidation of Secondary Metabolites from Fungi / Yang Liu." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1133261442/34.

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26

Mould, Katy M. "Studies towards the total synthesis and structure elucidation of leiodolide A." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/4113.

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Leiodolide A is a unique natural product isolated from Pacific marine sponges which has provided an interesting target for total synthesis due to its complex structure and undefined stereochemistry. Although synthetic work towards the synthesis of sister compound leiodolide B has been published, the total synthesis of leiodolide A is yet to be achieved but remains an important target due to high potency against leukaemia, non-small lung and ovarian cancers. The convergent strategy towards the synthesis of leiodolide A involved the synthesis of three subunits; a synthetic route to the C21-C25 v

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27

Keyes, Robert F. "Structure elucidation and studies relating to the synthesis of plasmalopentaene-12." Diss., This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-06062008-171532/.

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28

DAGANE, ISHAY. "Systeme darc-epios : elucidation structurale par rmn 13c. application du modele sous-structure/sous-spectre a la generation des structures." Paris 7, 1989. http://www.theses.fr/1989PA077265.

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Un systeme expert d'elucidation structurale a partir d'un spectre rmn 13c le systeme epios, a ete developpe. La base de connaissances de ce systeme est constituee de regles de production et d'un reseau d'objets, issus de l'analyse et de la modelisation des informations contenues dans une banque de donnees de 16000 composes et 21000 spectres. La saisie du spectre experimental d'un compose chimique, de sa formule moleculaire et des contraintes supplementaires eventuelles permettent de selectionner les fragments sous-structuraux susceptibles de figurer dans la structure cible et de creer un graph

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29

Al-Busaidi, Harith N. K. "Secondary metabolites from Xylaria endophytes : the isolation and structure elucidation of secondary metabolites from Xylaria endophytes by chemical and spectroscopic methods." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5266.

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30

Ashour, Mohamed A. A. "Structure elucidation of bioactive marine natural products using modern methods of spectroscopy." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982523963.

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31

Pillay, Pamisha. "Structure elucidation of antiplasmodial sesquiterpene lactones from Vernonia staehelinoides and Oncosiphon piluliferum." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-04162007-102438.

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32

Carr, Gavin. "Bioactive marine natural products : isolation, structure elucidation and synthesis of pharmacophore analogues." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23166.

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Bioassay-guided fractionation of the marine sponge Spongia irregularis led to the isolation of a new sulfated sesterterpenoid, irregularasulfate (2.16), along with two known sulfated sesterterpenoids, halisulfate 7 (2.14) and hipposulfate C (2.15). All three compounds (2.14-2.16) inhibit the related phosphatases calcineurin, PP1 and PP2A. The analogue 2.23 was synthesized and showed similar phosphatase inhibitory activity to the natural products. One new bafilomycin analogue, bafilomycin F (3.2), along with three known bafilomycin analogues, bafilomycin A1 (3.1), bafilomycin B1 (3.3) and ba

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33

Ahmad, Mansoor. "Investigations into the isolation, structure elucidation and biosynthesis of bioactive natural products." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/43414/.

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This project is divided into two parts. The first part of the project involved the investigation of fish toxins produced by Streptomyces species. Samples for fishexposure experiments were prepared from an actinomycete belonging to the S. griseus clade isolated from a site of major fish kills, as well as from the type strain, Streptomyces griseus DSM 40236. Fish-exposure samples were prepared through a series of consecutive HPLC separations. We were able to narrow down the highest level of fish toxicity to four fractions, each containing only a handful of compounds. Comparison of the metabolic

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34

Wang, Hao [Verfasser]. "Secondary Metabolites from Fungi: Diversity Enhancement, Structure Elucidation and Bioactivity / Hao Wang." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1152076272/34.

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35

Masento, Mark Steven. "Structure elucidation and synthesis of differentiation inducing factor (DIF) from Dictyostelium discoideum." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/47215.

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36

Williams, Russell Brian. "Isolation and Structure Elucidation of Cytotoxic Natural Products from Suriname and Madagascar." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/45831.

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Through a continuing search for anticancer compounds as part of an International Cooperative Biodiversity Grant program, the extracts of two plants were selected for study on the basis of their cytotoxic activity. These extracts were further fractionated to yield four compounds. The structures of these compounds were elucidated with mass spectrometry and 1-D and 2-D NMR spectroscopy. The ethyl acetate extract of the twigs of Garcinia macrophylla from Suriname was weakly cytotoxic in the A2780 human ovarian cancer cell bioassay. The known benzophenone guttiferone A and a new guttiferone anal

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37

Wang, Ming. "Isolation and Structure Elucidation of Antiproliferative and Antiplasmodial Natural Products from Plants." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/73742.

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As part of an International Cooperative Biodiversity Group (ICBG) program and a collaborative research project with the Natural Products Discovery Institute, four plant extracts were investigated for their antiproliferative and antiplasmodial activities. With the guidance of bioassay guided fractionation, two known antiproliferative terpenoids (2.1 and 2.2) were isolated from Hypoestes sp. (Acanthaceae), four known antiplasmodial liminoids (3.1-3.4) were isolated from Carapa guianensis (Meliaceae), one inactive terpenoid (4.1) was isolated from Erica maesta (Ericaceae), and four cerebrosides (

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38

Burke, Jocelyn W. "Isolation and structure elucidation of diterpenes from Kalmia angustifolia L. (var. caroliniana) /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487586889188629.

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39

Tran, Trong Duc. "Isolation and Structure Elucidation of Cytotoxic Natural Products with Potential Anticancer Activity." Thesis, Griffith University, 2010. http://hdl.handle.net/10072/365414.

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This project presented a strategy to select a subset of prefractionated fractions for screening. Marine and plant biota samples were chosen based on their rare taxonomies and mass spectroscopic data. A method to reduce 1155 fractions generated from 105 selected samples to 330 UV active fractions was developed. Cancer cell-based screening of 330 prefractionated fractions against four cancer cell lines (A549, HeLa, LNCaP and PC3) and non-cancer cells (HEK) resulted in nineteen active fractions belonging to fourteen biota samples (two plants and twelve marine organisms). One plant and six marine

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40

Nag, Swapan Kumar. "Chemical investigation on Terpene-isolation, structure elucidation, synthesis and reaction in triterpens." Thesis, University of North Bengal, 1989. http://hdl.handle.net/123456789/824.

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41

Dawood, Wisam Al-Ako. "Elucidation of the cell surface lipooligosaccharide structure of Moraxella bovoculi and its influence on the growth and biological activity of the microorganism." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/382710.

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Moraxella bovoculi is a Gram-negative microorganism that has shown potential to aide in the pathogenesis of infectious bovine keratoconjunctivitis (IBK) or ‘pink-eye’ in cattle. An ocular disease, IBK has shown to cause a significant economic loss to the cattle and dairy industry with reported losses of AUD 21 million annually to the beef industry in Australia.1 Infected animals show symptoms of keratitis, conjunctivitis, corneal ulceration and in severe cases, IBK can lead to permanent blindness.2 Currently, the only known cause for IBK is the Gram-negative bacterium Moraxella bovis. However,

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42

Al-Busaidi, Harith. "Secondary Metabolites from Xylaria Endophytes: The isolation and structure elucidation of secondary metabolites from Xylaria endophytes by chemical and spectroscopic methods." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/17479.

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This thesis describes the isolation and structure elucidation of secondary metabolites from a number of endophytic Xylaria fungi. Six Xylaria endophytes were surface cultured on an aqueous malt extract-glucose medium. The fungus A311R, from a palm tree in Thailand, produced nonane-1,2,3-tricarboxylic acid, which was isolated for the first time as a natural product. Also isolated from the same fungus was spiculisporic acid; the first instance of isolation from a Xylaria fungus. The fungus 6RD12 produced cycloepoxydon, which was isolated for the first time from a Xylaria fungus, and 4,5,6-trihyd

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43

Prota, Andrea E. "Structure elucidation of viral and human thymidine kinases and enolase from Alternaria alternata /." [S.l.] : [s.n.], 1999. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13456.

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44

Mavridou, Despoina A. I. "Elucidation of the structure-function relationships in the bacterial transmembrane disulfide oxidoreductase DsbD." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497048.

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45

Daletos, Georgios [Verfasser]. "Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Marine Sponges / Georgios Daletos." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1101693908/34.

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46

Ackerman, Louis Gabriel Jozua. "Structure elucidation of and synthetic approaches to monatin, a metabolite from Schlerochiton ilicifolius." Thesis, Stellenbosch : Stellenbosch University, 1990. http://hdl.handle.net/10019.1/57757.

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Thesis (PhD)--Stellenbosch University , 1990.<br>ENGLISH ABSTRACT: Monatin, or 4-hydroxy-4-(3-indolylmethyl) glutamic acid is a high-intensity sweet tasting amino acid found in the root bark of the indigenous plant Schlerochiton ilicifolius. In the thesis the isolation, structure elucidation and a number of synthetic approaches toward the total synthesis of monatin are described. Extensive fractionation of an aqueous extract of the root bark of S. ilicifolius using AG50WX8 strong acid cation exchange resin followed by successive gel filtration procedures using Biogel P2- and Sephadex G1

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47

Adam, Mohammed. "Isolation and structure elucidation of halogenated metabolites from Portieria hornemannii and Portieria tripinnata." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/64674.

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The red marine algal genus, Portieria, is known to produce a number of potent cytotoxic compounds with anticancer potential. The most important anticancer lead produced by this genus is the compound halomon. Unfortunately, the lack of sufficient quantities of this compound hampered its further development. Two Portieria species, Portieria hornemannii and Portieria tripinnata, are found along the South African coastline. Recent studies, based on DNA analysis, suggest that Portieria hornemannii may in fact be divided into several cryptic species. The current project is part of a larger study des

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48

Murphy, Margaret Clare. "The elucidation of structure-function relationships in bovine serum albumin by chemical modification." Thesis, University of Surrey, 1989. http://epubs.surrey.ac.uk/844202/.

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The potential of using chemical modification as a tool to determine structure-function relationships was examined using one standard protein namely bovine serum albumin. The chemical modifications investigated included succinylation with succinic anhydride; thiolation, using N-acetyl homocysteine thiolactone; guanidination with O-methylisourea; the addition of cysteine hydrochloride; attachment of valine using an N-carboxyl anhydride derivative and of butylamine, putrescine and lysine via carbodiimide mediated condensation reactions. The native and modified proteins were subjected to a set of

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49

Presley, Christopher Charles. "Isolation, Structure Elucidation, and Total Synthesis of Biologically Active Natural Products from Plants." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/79978.

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As a part of the continuing search for bioactive compounds with the Madagascar International Cooperative Biodiversity Group (ICBG), and in collaboration with the Natural Products Discovery Institute of the Institute for Hepatitis and Virus Research (IHVR), thirteen plant extracts were investigated for antiplasmodial activity, thirteen plant extracts were investigated for antiproliferative activity, and one extract was investigated for inhibitors of the shikimate pathway in Plasmodium falciparum. Bioassay-guided fractionation of the extracts led to the identification of nineteen compounds with

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50

Chen, Ru. "Isolation, structure elucidation and approaches to the partial synthesis of new taxol analogs." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-11102009-020316/.

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