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Journal articles on the topic 'Sustain Release'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre

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2

S. Jat, Deepak, Swati G. Talele, Akshada A. Bakliwal, and Anil G. Jadhav. "DESIGN, DEVELOPMENT AND EVALUATION OF ALOGLIPTIN AND METFORMIN HYDROCHLORIDE BILAYER TABLET." Indian Drugs 59, no. 07 (2022): 74–76. http://dx.doi.org/10.53879/id.59.07.12280.

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The objective of the present work was to formulate and evaluate bilayer tablets of alogliptin and metformin HCl. Combining alogliptin with metformin HCL gives additional benefits in comparison with either drug alone and could be considered for patients whose quality of life is impaired by diabetes mellitus. The study was performed to design bilayer tablets of alogliptin immediate release layer and metformin HCl sustained release layer by wet granulation method. The immediate release layer comprised Crospovidone superdisintegrant and sustained release layer comprised HPMC K4M as rate release co

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3

Pralhad, Kanke. "DEVELOPMENT OF DISINTEGRATION CONTROL MATRIX TABLETS OF FEBUXOSTAT." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (2018): 12–20. http://dx.doi.org/10.22270/ajprd.v6i4.392.

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Disintegration control matrix tablet (DCMT) is a new approach for poorly water soluble drugs which successfully sustain the release up to 24hrs by controlling the disintegration rate of tablet. DCMT mainly forms the granules containing drug febuxostat and disintegrant sodium alginate which controls the release of febuxostat by controlling the rate of disintegration in wax coating plays an important role. The sustained release of drug is maintained by increasing the wax coating or decreasing the amount of disintegrant. The release of drug from tablet is uniform throughout till all the drug rele

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4

KUSHWAH, MAHENDRA SINGH. "NANOPARTICLE FOR SUSTAIN RELEASE OF ACYCLOVIR INVITRO AND INVIVO DRUG COMPARTMENT MODELLING." International Journal Of Multidisciplinary Research And Studies 04, no. 11 (2018): 01–11. http://dx.doi.org/10.33826/ijmras/v04i11.2.

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The main objective of this study was to organize the In-Vitro and In-Vivo correlation of immediate release Acyclovir tablets of 800 mg. In vitro and in vivo studies are done on the test product as Acyclovir Tablet USP 800 mg (containing Acyclovir 800 mg) of Cadila Medicinals Ltd., India versus Zovirax Tablet 800 mg (containing Acyclovir 800 mg) of GlaxoSmithKline, USA. In vivo studies are done in 36 healthy, adult, mortal subjects under fasting conditions. In vitro dissolution study was done using USP outfit II at 50 rpm in0.1 N HCL for 45 twinkles. The in vitro – in vivo interdependence of Ac

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Kumar, Deepak, ,. Archana, and Abadhesh Kumar Niranjan. "A Comprehensive Review on Sustained Release Matrix Drug Delivery System." Journal of Drug Delivery and Therapeutics 12, no. 4-S (2022): 249–53. http://dx.doi.org/10.22270/jddt.v12i4-s.5540.

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Formulations for sustained medication release are very useful in the treatment of chronic disorders. The oral route has selected matrix tablets as the most likely type of prolonged drug release. In order to generate therapeutic activity for a protracted duration, matrix tablets maintain a stable plasma drug concentration and sustain the rate of release of the drug throughout time. In preparations with a short half-life and high dosage frequency, extended-release is crucial. The matrix regulates how quickly the medication is released. Retardants such polyglycolic acid, polymethyl methacrylate,

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Gaware, Ravi U., Sujit T. Tambe, Shankar M. Dhobale, and Suresh L. Jadhav. "Formulation and in-vitro evaluation of theophylline sustained release tablet." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 48–51. http://dx.doi.org/10.22270/jddt.v9i1-s.2252.

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The aim of present study was to prepare sustained release tablet of Theophylline so as to prolong its elimination time and at the same time to keep cost of the formulation minimum. In this study ethyl cellulose and Eudragit are used in the formulation to sustain the release of Theophylline. Ethyl cellulose and Eudragit are added at the granulation step to form a sustained release coating around each granule. Different batches were designed one after another on trial and error basis to get the optimum drug release upto 12 hours. Keywords: Theophylline, ethyl cellulose, Eudragit, sustained

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7

Munisso, Maria Chiara, Naoki Morimoto, Sharon Claudia Notodihardjo, Toshihito Mitsui, Natsuko Kakudo, and Kenji Kusumoto. "Collagen/Gelatin Sponges (CGSs) Provide Both Protection and Release of bFGF: An In Vitro Study." BioMed Research International 2019 (February 19, 2019): 1–9. http://dx.doi.org/10.1155/2019/4016351.

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It has been reported that collagen/gelatin sponges (CGSs) are able to sustain the release of basic fibroblast growth factor (bFGF) for approximately 10 days via the formation of ion complexes between bFGF and gelatin. CGSs impregnated with bFGF have been proven to promote dermis-like tissue formation in various in vivo studies and clinical trials. However, the bioactivities of bFGF released from CGSs have not been explored in vitro. In this study, we explored the ability of CGS impregnated with bFGF, stored at 37°C for up to 14 days, to promote fibroblast proliferation and the sustained releas

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8

Khoder, Mouhamad, Henry Gbormoi, Ali Ryan, Ayman Karam, and Raid Alany. "Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads." Pharmaceutics 11, no. 2 (2019): 83. http://dx.doi.org/10.3390/pharmaceutics11020083.

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In this study, bovine serum albumin (BSA) and alginate (ALG) conjugates were synthesized by the Maillard reaction in order to evaluate their potential to develop controlled release drug delivery systems. The progress of the Maillard reaction was evidenced using ultraviolet (UV) absorbance, determination of BSA remaining free amino groups, and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). BSA-ALG conjugates possessed enhanced and tunable viscosity, foamability and foam stability. Foam generated from BSA-ALG conjugate solution was used to prepare floating gastroretentive

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9

Văn Thoại, Phạm, and Nguyen Hai Nam. "Design and Synthesis of Sustain-Acting Melatonin Prodrugs." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/684760.

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Twelve melatonin amide prodrugs aiming at prolonging the action of melatoninin vivoby improving its half-life were designed and synthesized. Using an 80% human plasma model, it was found that the aliphatic amide derivatives were relatively stable and melatonin release from these compounds was not sufficient with melatonin release percentage. After 4-hour incubation with 80% human plasma, the melatonin release percentage achieved only approximately less than 20%. In contrast, the -succinyl and -glutaroylmelatonin derivatives (compounds11and12, resp.) were found to release melatonin in much high

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10

Mandhan, Rahul, and Twinkle Garg. "Sustained Release Matrix Technology for Cefixime- A Review." International Journal of Pharmaceutical Sciences and Medicine 7, no. 8 (2022): 10–19. http://dx.doi.org/10.47760/ijpsm.2022.v07i08.002.

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Sustained release drug delivery system is designed to sustain the release of the drug dosage forms at a predetermined rate. Sustained release formulation maintains uniform drug level in therapeutic window, improved efficacy of drug by localization at the site of action with better patient compliance, reducing the dose required, providing uniform drug delivery. The sustained release formulations minimize the frequency of drug administration and do not interfere with the therapeutic action of the drug. The use of sustained release matrix technology for antibiotics is effective in preventing the

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11

Khamkaew, Namfon, Sorada Kanokpanont, Jirun Apinun, Chalika Wangdee, Antonella Motta, and Siriporn Damrongsakkul. "Physico-Chemical Characterizations of Composited Calcium-Ortho-Phosphate Porous Particles and Their Controlled Release Behavior of Clindamycin Phosphate and Amikacin Sulfate." Polymers 16, no. 22 (2024): 3144. http://dx.doi.org/10.3390/polym16223144.

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The porous particles prepared from composited calcium–ortho-phosphate (biphasic), Thai silk fibroin, gelatin, and alginate, with an organic to inorganic component ratio of 15.5:84.5, were tested for their abilities to control the release of the commercialized antibiotic solutions, clindamycin phosphate (CDP) and amikacin sulfate (AMK). The in vitro biodegradability tests complying to the ISO 10993-13:2010 standard showed that the particles degraded <20 wt% within 56 days. The drugs were loaded through a simple adsorption, with the maximum loading of injection-graded drug solution of 43.41 w

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Kalbhare, Shankar, Rohit K. Pawar, Vivekkumar K. Redasani, Amita B. Yadav, Vishal R. Mohite, and Vaibhav B. Kadam. "Role of Aminated Derivatives of Natural Gum in Release Modulating Matrix System of Losartan Potassium." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 6 (2022): 6204–15. http://dx.doi.org/10.37285/ijpsn.2022.15.6.3.

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Objective: The investigation aimed to synthesize amino derivatives of various natural gums like Xanthan gum and Tamarind gum for using them as a release modulating polymer in the formulation of the hydrophilic matrix system of losartan potassium and to find the best amongst them. Developing oral sustained release matrix tablets for a drug with a constant release rate has always been a challenge to the pharmaceutical technologist.  Materials and Methods: Release modulating hydrophilic matrix tablets of losartan potassium were prepared by wet granulation method. A total number of 6 formula

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13

Adiwidjaya Kusuma, Gregorius, Ayu Aulia, Censa Lumayung, et al. "Literature Review - Sustained Release In Liposom Technology On Emulsion Cream Curcumin For Burns." Science and Community Pharmacy Journal 2, no. 1 (2023): 99–104. https://doi.org/10.63520/scpj.v2i1.353.

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Preface : Burns is an injury on tissue caused by overexposure to flame, steam, hot liquid, chemist substances, electrical objects and radiant. Burns are classified based on its region and degree. One of the most important factors that affect the process of burns treatment is the prevention of burns infection. Turmeric is a natural resource that may be used. Its extract helps to haste re-epithelialization, cell proliferation and collagen synthesis. Proper sustain to improve the therapy is topical sustain. Liposom is one of topical sustains which is developed in pharmacy to increase efficacy. On

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14

Prajapat, Priyanka, Dilip Agrawal, and Gaurav Bhaduka. "A brief overview of sustained released drug delivery system." Journal of Applied Pharmaceutical Research 10, no. 3 (2022): 05–11. http://dx.doi.org/10.18231/j.joapr.2022.10.3.5.11.

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The most popular and patient-friendly method of drug administration is often thought to be the oral route of administration. Compared to conventional release formulations, advancements in formulation technology, including modified release dosage forms or sustained release oral dosage forms, have been extensively accepted. A sustained release dosage form provides a prolonged release of the drug over an extended period, thereby giving better patient compliance and enhanced bioavailability. Sustain release systems are considered a wiser approach for drugs with short half-lives requiring repeated

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15

Gopal Gajanan Wagh, Vinay Mahajan, Ramakant Sharma, and Revathi A. Gupta. "Optimization and evaluation of bilayer tablet of probenecid." World Journal of Biology Pharmacy and Health Sciences 18, no. 1 (2024): 388–98. http://dx.doi.org/10.30574/wjbphs.2024.18.1.0226.

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The main objective of my research work is to develop a bilayer tablet of Probenecid, in which one layer is immediate layer for immediate action and second layer is the sustain release layer for maintaining the dose of the drug. Probenecid is frequently administered up to 3 times in a day. So, the reducing dosing frequency by sustained release tablet.

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Gopal, Gajanan Wagh, Mahajan Vinay, Sharma Ramakant, and A. Gupta Revathi. "Optimization and evaluation of bilayer tablet of probenecid." World Journal of Biology Pharmacy and Health Sciences 18, no. 1 (2024): 388–98. https://doi.org/10.5281/zenodo.13729715.

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The main objective of my research work is to develop a bilayer tablet of Probenecid, in which one layer is immediate layer for immediate action and second layer is the sustain release layer for maintaining the dose of the drug. Probenecid is frequently administered up to 3 times in a day. So, the reducing dosing frequency by sustained release tablet.

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17

Gayathri R and Sundaraganapathy R. "Design, optimization and comparative IN VITRO evaluation of sustain release matrix tablet using ARAUCARIA HETEROPHYLLA gum." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (2019): 2109–16. http://dx.doi.org/10.26452/ijrps.v10i3.1435.

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The present study deals with the formulation of oral sustained-release tablets using natural gum Araucaria heterophylla gum, and the results were compared the formulations with existing polymers. The gum was isolated from the bark exudates of Araucaria heterophylla tree Sustain release matrix tablets of aceclofenac as a model drug were prepared with the proportions 15%, 20%, 25% and 30% of Araucaria heterophylla gum by direct compression method. The results were compared with sustain release matrix tablets formulated from similar proportions of Guar gum and HPMC K4M. The tablets were evaluated

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Amit, Dubey* Kusum Kumari Lubna Shaheen Manish Kumar Mo Rayyan Mohammad Saklain Mohd Aarif Khan. "Formulation and Evaluation of Paracetamol Matrix Tablet Using Natural Polymer." International Journal of Scientific Research and Technology 2, no. 5 (2025): 542–47. https://doi.org/10.5281/zenodo.15515718.

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Matrix tablets of Paracetamol were prepared utilizing natural polymer chitosan. The tablets represented sustained drug release which is required for the drugs like Paracetamol with low bioavailability and low half life. The tablets can sustain the drug release which can overcome such problems. Moreover the tablets contain chitosan which also is a permeability enhancer and hence could be utilized to increase the permeability of the drugs like Paracetamol with very low permeability. The tablets possess high potential for being developed as sustained release dosage forms for drugs with low permea

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Elsayed, Mahmoud M. A., Moustafa O. Aboelez, Mohamed S. Mohamed, et al. "Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study." Pharmaceutics 14, no. 8 (2022): 1629. http://dx.doi.org/10.3390/pharmaceutics14081629.

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Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The purpose of this study is to make rosuvastatin calcium (ROS) and atenolol (AT) bilayer tablets to treat coexisting dyslipidemia and hypertension with a single product. ROS was chosen for the immediate-release layer of the constructed tablets, whereas AT was chosen for the sustained-release layer. The solid dispersion of ROS with sorbitol (1:3 w/w) was utilized in the immediate-release layer while hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC), and sodium bicarbonate were incorporated into th

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20

Deepthi, V. Phani, AMPAPURAM RAJESH PAVAN, G. Naresh Babu, and K. Sreenivasulu. "Formulation and Evaluation of Prulifloxacin Sustained Release Matrix Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 72–81. http://dx.doi.org/10.22270/jddt.v9i4.2974.

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Prulifloxacin is a chemotherapeutic antibiotic of Fluor quinolone drug used to treat a various urinary tract infections. It has short half-life, makes the sustained release (SR) forms extremely advantageous. Sustained release tablets results in increased bioavailability. The purpose of the present study was to develop a sustain release matrix drug delivery system (SR) containing Prulifloxacin as a model drug by using various proportions of polymers such as HPMC E15, HPMC K15. The sustained release formulations of Prulifloxacin were prepared by direct compression method. Optimization of formula

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Nayyar, Parvez, Yadav Suman, and A.K.Bakhshi. "DESIGN OF KETOCONAZOLE MICROSPHERES - FORMULATIVE APPROACHES." Continental J. Medical Research 1 (November 4, 2007): 13–23. https://doi.org/10.5281/zenodo.3526867.

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Sustained release microspheres containing ketoconazole were prepared using 22 factorial design and were characterized for their release properties and micromeritic properties (intraquartile coefficient of skewness and kurtosis). The surface topography of the microspheres was investigated with scanning electron microscopy.  In vitro drug release studies were performed using modified USP apparatus I in 0.1N HCl pH 1.20 for 2 h followed by phosphate buffer pH 7.20 as dissolution medium at 37°±0.5°C at 50 rpm for the next 6 h.  Maximum drug release was observed with the KT

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Samrudh, Shinde Shivaji Patil Namrata Satkar Pritam Salokhe Nilesh Chougule. "Formulation And Evaluation Of Floating Sustain Release Tablet Of Ranolazine." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1505–16. https://doi.org/10.5281/zenodo.12788828.

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This research focuses on the formulation and evaluation of floating sustained-release tablets of Ranolazine, an anti-anginal agent with poor bioavailability and short half-life. The tablets were prepared using various polymers such as hydroxypropyl methylcellulose (HPMC) and sodium alginate to achieve controlled drug release and prolonged gastric residence time. The formulation was optimized using a 32 full factorial design to study the effect of independent variables like polymer concentration and tablet hardness on drug release kinetics and floating behavior. The prepared tablets exhibited e

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Wagh, Vijay D., and Nilesh Pawar. "Development and Evaluation of Sustained Release Tablet of Betahistine Hydrochloride Using Ion Exchange Resin Tulsion T344." ISRN Pharmaceutics 2012 (June 18, 2012): 1–5. http://dx.doi.org/10.5402/2012/438342.

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An attempt was made to sustain the release of Betahistine hydrochloride by complexation technique using strong cation-exchange resin, Tulsion T344. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, swelling time, ratio of drug : resin, and temperature. The resinate was evaluated for micromeritic properties and characterized using XRPD and IR. For resinate sustained release tablets were formulated using hydoxypropyl methylcellulose K100M. The tablets were evaluated for hardness, thickness, friability, drug content, weight variation, and in vitro d

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Lian, Yuan, Hong Mei Wang, Da Peng Zhou та Dan Liu. "Preparation and Characterization of β-Cyclodextrin-Based Microcapsules for Sustaining Release of Jasmine Oil". Advanced Materials Research 239-242 (травень 2011): 624–27. http://dx.doi.org/10.4028/www.scientific.net/amr.239-242.624.

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A fragrance, jasmine was encapsulated into β-cyclodextrin to prepare microcapsules that can sustain the release of the fragrance and potentially be bound to textile material. This study examined the structures, thermal properties, partied size distributions, and release behaviors of the microcapsules. The release of jasmine was examined in air at elevated temperature. The experiments showed that β-cyclodextrin could efficiently sustain the delivery of jasmine.

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Patil, Sangram M., Rakesh V. Mishra, and Satish V. Shirolkar. "Development and Evaluation of Sustain Release Simvastatin Pellets." Research Journal of Pharmacy and Technology 10, no. 8 (2017): 2467. http://dx.doi.org/10.5958/0974-360x.2017.00436.x.

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Patel, Anand, C. C. Patil, R. V. Kulkarni, et al. "Development and Evaluation of Sustain Release Pioglitazone Microsphere." Research Journal of Pharmacy and Technology 11, no. 12 (2018): 5348. http://dx.doi.org/10.5958/0974-360x.2018.00974.5.

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Shaikh, Siraj Nawaj* Md. ZuberPatel G. J. Khan Patel M. Siddik ZakirShaikh. "DESIGN AND EVALUATION OF BILAYER FLOATING TABLETS OF DILTIAZEM HCL." ndo American Journal of Pharmaceutical SciencesI 04, no. 08 (2017): 2612–21. https://doi.org/10.5281/zenodo.858667.

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The present investigation concerns design and evaluation of bilayer floating tablets of Diltiazem HCl Diltiazem HCl is Class I drug, though its reported bioavailability is only 40 %. It is having very short half life of 3 to 4 hrs. Hence many sustained release formulations were developed for Diltiazem HCl. A direct compression method was used to formulate all batches. 32 factorial design was applied to study % cumulative drug release and hardness. Super disintigrants like Sodium starch glycolate was used for immediate release layer and HPMC K200 M, Xanthan gum like polymers were used in floati

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Accha, D.M.1* Kshirsagar S.S.2. "Optimization and Evaluation of Modified Dosage form of Antihypertensive Drug." International Journal of Pharma Research and Technology 1, no. 4 (2022): 1–15. https://doi.org/10.5281/zenodo.7505191.

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The goal of the current study is to produce a modified dose form of the hypertension drug Valsartan. Without any issues, sustained release tablets were compressed, and the formulation's excipient ratio was left unchanged. We seek to develop drug delivery systems with a typical sustained release pattern in order to achieve therapeutic concentrations of the medications at the point of their maximum necessity in the body. Wet granulation technology was used in this research project to create sustained release matrix tablets employing a variety of polymers and excipients. The bulk density, com

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Mukul, Sharma1 &. Shivani Dubey2. "RELEASE KINETIC STUDY OF NOVEL TRANSDERMAL PATCH OF ANALGESIC DRUG CONTAINING PERMEATION ENHANCER." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES [FRTSSDS- June 2018] (June 22, 2018): 263–70. https://doi.org/10.5281/zenodo.1296220.

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Transdermal drug delivery system (TDDS) represents one of the most rapidly advancing areas of novel drug delivery. TDDS are designed for controlled release of drug through the skin into systemic circulation maintaining consistent efficacy and reducing dose of the drug and its related side effects. Present study was conducted to prepare transdermal patch of Mefenemic acid with permeation enhancer to reduce extra side effects and to provide sustain drug delivery. The optimized formulations were examined by various kinetic models such as zero-order, first-order, Higuchi equation, Korsemeyer&ndash

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R., Narayana Charyulu, Gandhi Kinjal B., Jobin Jose, Sneh Priya, and Shastry C. S. "INFLUENCE OF BIOENHANCERS ON THE RELEASE PATTERN OF NIOSOMES CONTAINING METHOTREXATE." Journal of Health and Allied Sciences NU 02, no. 02 (2012): 36–40. http://dx.doi.org/10.1055/s-0040-1703568.

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AbstractThe aim of present study was to prepare sustained release formulations of niosomes of methotrexate (MTX) alone (N1 to N10) and along withbioenhancers (NB1 to NB9) by thin film hydration technique using span 60 as surfactant,cholesterol as membrane stabilizing agent, curcumin and piperine as bioenhancers and dicetyl phosphate (DCP) as charge inducing agent. All the formulations of niosomeswere characterized on the basis of physical appearance and entrapment efficiency. The invitro releasestudies of optimized formulation of niosomes of MTX alone and along with bioenhancers were performed

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Tejaram. "Formulation and Evaluation of Cefixime Loaded Grafted Gellan Gum Tablet." International Journal of Pharmacy and Biological Sciences (IJPBS) 13, no. 3 (2023): 89–98. https://doi.org/10.5281/zenodo.10429853.

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AbstractThe objective of the present work is to design sustained release tablets of cefixime by incorporating drug with polymer using microwave assisted graft co-polymerization method. In the present study, Gellan gum was used as a polysaccharide and grafted with acrylamide to make a sustained release formulation of cefixime which can solve mainly problem associated with multiple dose frequency and it can also increase patient compliance. The effect of combination of polymers on parameters like release pattern, release mechanism of the drug were studied. Preparation of total Seven formulation

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Salih, Omar Saeb, and Roaa Abdalhameed Nief. "EFFECT OF NATURAL AND SYNTHETIC POLYMERS ON THE PROPERTIES OF CANDESARTAN CILEXETIL MATRIX TABLET PREPARED BY DRY GRANULATION." Asian Journal of Pharmaceutical and Clinical Research 9, no. 9 (2016): 161. http://dx.doi.org/10.22159/ajpcr.2016.v9s3.14719.

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ABSTRACTObjective: The objective of this study is to develop a controlled release matrix tablet of candesartan cilexetil to reduce the frequency of administration,enhance bioavailability and improve patient compliance; a once daily sustained release formulation of candesartan cilexetil is desirable.Methods: The prepared tablets from F1 to F24 were evaluated with different evaluation parameters like weight variation, drug content, friability,hardness, thickness and swelling ability. In vitro release for all formulas were studied depends on the type and amount of each polymer, i.e. (16 mg,32 mg

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Venkateswarlu, Kambham. "Evaluation of glibenclamide microspheres for sustained release." Journal of Pharmacy & Pharmacognosy Research 5, no. 1 (2017): 78–87. http://dx.doi.org/10.56499/jppres16.156_5.2.78.

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Context: Sustained release drug delivery systems are more preferred than the conventional drug delivery systems due to its enhanced bioavailability and patient compliance. Earlier studies reported on glibenclamide (GBCM) were not clear and hence, the step has been taken to explore the sustained release drug delivery system of GBCM. Aims: To evaluate the sustained release microspheres obtained of GBCM. Methods: Microspheres were prepared by ionic gelation method using the polymers like Eudragit RS 100 and xanthan gum. Polymers can sustain the drug release from microspheres. The prepared microsp

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Sahu, Ayush, Khushi Chouksey, and Kuldeep Ganju. "FORMULATION AND EVALUATION OF CIPROFLOXACIN HYDROCHLORIDE SUSTAINED RELEASE TABLETS USING HIBISCUS ROSA SINENSIS MUCILAGE." Journal of Advanced Scientific Research 13, no. 08 (2022): 71–78. http://dx.doi.org/10.55218/jasr.202213811.

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Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Delivery systems extended release or controlled release rate can achieve predictable and reproducible, the extended duration of activity for the short time of life - drugs, reduced toxicity, and dose reduction request, the optimized therapy and better patient compliance. It is controlled primarily by the type and the proportion of the polymers used in the preparation. Ciprofloxacin hydrochloride is an extreme

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Ujjwal, Kukreti, Nainwal Nidhi, Ale Yogita, et al. "Release Kinetic of Sustained Release Matrix Tablet of Linezolid Containing Polymer Blend." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1479–84. http://dx.doi.org/10.25258/ijpqa.15.3.60.

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Tuberculosis (TB) is a bacterial infection mainly affecting the lungs. TB is a major health problem worldwide and the occurrence of extensively drug-resistant TB (XDR-TB) and multidrug-resistant TB (MDR-TB) offers considerable hurdles to effective treatment and disease management. The growth of treatment-resistant Mycobacterium TB strains has prompted the investigation of alternate therapeutic techniques, including the application of sustained drug delivery. Sustained-release drugs reduce the need for frequent dosing can extend the effects of linezolid by 8 to 12 hours, thus improving the pati

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Vigneshwaran, LV, Abdullakunhi Thasneem, Irfana BM Fathimath, PV Thushara, Sebastin V., and Babu TK Ajith. "DERMAL DRUG DELIVERY THROUGH NANOCARRIERS." World Journal of Pharmaceutical Science and Research 2, no. 4 (2023): 25–28. https://doi.org/10.5281/zenodo.10897614.

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Nanocarriers have been explored for delivering drugs and other bioactive molecules for well over 35years. Since the introduction of a nanoliposomal delivery system for the cancer drug doxorubicin, several products have been approved worldwide. The majority of these products focus on cancer chemotherapy, and utilize the size advantage of nanocarriers to obtain a favourable distribution of the drug carrier in the human body. In general, such carriers do not sustain drug release over more than a few days at best. A variety of nanocarriers have been studied, and their advantages and shortcomings a

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Gore, Mr Kailas B., Miss Nandini patil, and Dr Megha T. Salve. "Formulation and evaluation of sustain release metformin tablets by wet granulation method for Enhanced Patient Compliance." International Journal of Research Publication and Reviews 6, no. 5 (2025): 12983–90. https://doi.org/10.55248/gengpi.6.0525.1911.

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Bibek, Kundu Anuranjita Kundu*. "Perspective Impact of Gelling Agents on the Permeation Behavior for the Topical Delivery of Itraconazole Gel." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1718–23. https://doi.org/10.5281/zenodo.14899147.

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Itraconazole is a broad spectrum anti-fungal agent which is used to treat various type of antifungal infections. Itraconazole can be given orally but it has side effects such as hepatotoxicity, kidney damage and reproductive issues, so if it is used topically then it has less side effects as compare to its oral administration. Topical administration of Itraconazole ensures site specific delivery for its high permeability that will help to avoid tissue toxicity.   Gums and polymers are abundant in nature and come from a variety of marine, microbial, and plant sources and also can be s

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Jeevanandham, S., M. Sekar, M. Muthukumaran, N. Sriram, J. Joysaruby, and D. Dhachinamoorthi. "Sustain-Release of Various Drugs from Leucaena Leucocephala Polysaccharide." Journal of Young Pharmacists 2, no. 1 (2010): 15–20. http://dx.doi.org/10.4103/0975-1483.62207.

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Venkateswara Reddy, B., and K. Navaneetha. "FORMULATION AND EVALUATION OF SUSTAIN RELEASE CYCLOBENZAPRINE HYDROCHLORIDE PELLETS." INDIAN DRUGS 54, no. 05 (2017): 19–25. http://dx.doi.org/10.53879/id.54.05.10262.

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Cyclobenzaprine Hydrochloride is a centrally acting muscle relaxant which is mostly available in the form of tablets and capsules. The present aim of the study was to develop a sustained release formulation of cyclobenzaprine Hydrochloride pellets using powder layering technique. Nine different formulations of pellets were prepared by using different concentrations of Ethyl Cellulose-50, Hypromellose (HPMC), and PEG 6000 of all formulations, F8 formulation was the optimized formulation. The kinetic studies of F8 formulation was best fitted in the First order model as it had the highest value (

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Gondkar, S. B., P. Shewale Lankesh, and R. B. Saudagar. "An Overview on Sustain Release Matrix Drug Delivery System." Research Journal of Pharmaceutical Dosage Forms and Technology 8, no. 2 (2016): 154. http://dx.doi.org/10.5958/0975-4377.2016.00020.3.

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Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.

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Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4,

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Priya, Patil*and Vijay R. Mahajan. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET QUETIAPINE FUMARATE BY USING NATURAL POLYMER." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2018): 4859–67. https://doi.org/10.5281/zenodo.1134591.

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The purpose of present study was to develop once a day sustained release matrix tablet of Quetiapine Fumarate by using natural polymer viz. Xanthan gum and isolated fenugreek mucilage. Varying ratios of drug and polymer like were selected for sustained release tablet by using direct compression method. After fixing the ratio of drug and polymer for Sustain the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling material. After evaluation of physical properties of tab

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Genç, Lütfi, and A. Kıran. "In Vitro Evaluation of Sustained Released Matrix Tablet Formulations of Clarithromvcin." Scientia Pharmaceutica 73, no. 1 (2005): 59–74. http://dx.doi.org/10.3797/scipharm.aut-05-05.

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Sustained release matrix tablets of clarithromycin were prepared using different polymers as Hydroxypropyl methylcellulose (H PMC), Carbopol 934 and Eudragit RL/PO by direct compression technique. For the quality control of these formulations, weight deviation, hardness, friability, diameter-height ratio, content uniformity of the active substance and in vitro dissolution technique were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. Dissolution profiles of the tablets were plotted and evaluated kinetically. The effects on drug release of polymer ty

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R, Joan Vijetha, Kaviyarasan K, Annie Bhuvana Mary A, Gopinath N, and Sam Daniel J. "Formulation And Evaluation Of Metformin Hydrochloride Sustained Release Capsule." Journal of Neonatal Surgery 14, no. 12S (2025): 441–57. https://doi.org/10.52783/jns.v14.3200.

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Metformin Hydrochloride (MH) is a synthesis of N, N -dimethyl guanidine, a type of medicament which is used to treat type II diabetes. Emil Worner and James Belt in the year 1922 were the first to synthesized dimethyl guanidine. MH has various other advantages such as; weight loss, improper fertility, slowing down the tumour growth and few more. The current work is focused on, to sustain the release of the drug in the body for a larger period of time. To perform this study various factor were taken into consideration such as drug, Excipients (HPMC, PVP K30, Magnesium stearate, MCC, NaCMC and S

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Rosli, Nur Ayshah, German A. Islan, Rosnani Hasham, Guillermo R. Castro, and Azila Abdul Aziz. "Incorporation of Nanoparticles Based on Zingiber Officinale Essential Oil into Alginate Films for Sustained Release." Journal of Physical Science 33, no. 2 (2022): 107–24. http://dx.doi.org/10.21315/jps2022.33.2.7.

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This research focused on the formulation of Ca2+ cross-linked alginate (Alg) gels containing Zingiber officinale oil extract (ZOE) loaded into a nanostructured lipid carrier (NLC). The NLC is intended to protect the Zingiber officinale oil against physical and chemical degradation during topical administration to sustain the drug release and reduce drug leakage during storage. The NLC was prepared using hot homogenisation and ultrasonication of glyceryl monostearate. Virgin coconut oil was used as the liquid lipid. The NLC-ZOE had a mean size diameter of 100 nm and a zeta potential value of −4

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Patel, Anand J., Deep R. Naik, and Jignesh P. Raval. "Sustain Release Formulation and Evaluation of Ofloxacin Floating Delivery System." International Letters of Chemistry, Physics and Astronomy 31 (March 2014): 69–83. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.31.69.

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Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone c

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Patel, Anand J., Deep R. Naik, and Jignesh P. Raval. "Sustain Release Formulation and Evaluation of Ofloxacin Floating Delivery System." International Letters of Chemistry, Physics and Astronomy 31 (March 28, 2014): 69–83. http://dx.doi.org/10.56431/p-77x959.

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Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone c

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Sujit, Ubale, Shinde Tejasvee, and Shaikh Adnan. "Phenhylephrine Hydrocloride Gastro Retentive Floating Matrix Tablets Design and in Vitro Evaluation." International Journal of Trend in Scientific Research and Development 3, no. 6 (2019): 588–92. https://doi.org/10.5281/zenodo.3588744.

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The objective of this research is to obtain sustained release of Phenylephrine hydrochloride. In this research work combination of natural and synthetic gums were used in different ratio to get sustain release different gas generating agents were used to float the tablet. Prepared powder blend is subjected to pre formulation studies. Then prepared tablet were evaluated for different evaluation tests. Finally dissolution data was subjected to various release kinetic models to understand release mechanism of drug. Sujit Ubale | Tejasvee Shinde | Adnan Shaikh "Phenhylephrine Hydrocloride Gas

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Kumari, Poonam, and Rahul Shukla. "Preformulation Studies for an Intra-Gastric Floating Drug Delivery System of Clarithromycin to Sustain Its Release." Journal of Neonatal Surgery 14, no. 10S (2025): 310–20. https://doi.org/10.52783/jns.v14.2796.

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The development of an intragastric floating drug delivery system (FDDS) for clarithromycin aims to enhance its bioavailability and sustain its release within the stomach. Clarithromycin, a macrolide antibiotic, is widely used to treat Helicobacter pylori and respiratory tract infections but suffers from poor solubility in gastric fluids and limited bioavailability. This study focused on preformulation studies, including organoleptic evaluation, solubility analysis, drug-excipient compatibility studies using FT-IR and DSC analysis, and in vitro drug release profiling. The floating system was de

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