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Dissertations / Theses on the topic 'Suzuki-Miyaura reaction'

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Published: 4 June 2021
Last updated: 26 July 2025

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1

Hashimoto, Toru. "Development of Iron-Catalyzed Suzuki-Miyaura Coupling Reaction." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/159407.

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2

Geogheghan, Katherine Jayne. "Boronic acid speciation in Suzuki-Miyaura cross-coupling." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33092.

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Since its discovery in 1979, the Suzuki-Miyaura (SM) reaction has become one of the most widely utilised tools for carbon-carbon bond formation. The palladium catalysed coupling of an organoboron and organohalide compounds proceeds through a three-stage mechanism of oxidative addition, transmetalation and reductive elimination. The transmetalation of boronic acids to a palladium(II) complex has been widely studied. However, very little is known about the transmetalation of boronic esters, which are commonly used as an alternative to unstable boronic acids. Whether these species undergo direct
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3

Bourouina, Amine. "Desperately Seeking For The Catalytic Species In Suzuki-Miyaura Reaction." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1258.

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L’état de l’art montre que l’utilisation de Pd supporté sans ligand est une idée séduisante car elle permet d’éviter les problèmes liés à la présence des ligands potentiellement coûteux et toxiques, et également de récupérer plus facilement le catalyseur en fin de réaction. Ainsi, il est plus aisé de respecter la réglementation fixant la teneur maximale de Pd dans les principes actifs pharmaceutiques (IPA) à une concentration inférieure à 10 ppm. Cependant, la présence des espèces (moléculaires ou nanoparticules) de Pd en solution lors de l’utilisation de catalyseurs solides a créé un débat im
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4

Payard, Pierre-Adrien. "Mechanistic studies of metal-catalyzed reactions : predicting tools for reaction optimization." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEE009/document.

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Cette thèse est consacrée à l’étude de mécanismes de réactions catalysées par des métaux ainsi qu’au développement de nouveaux outils pour la rationalisation et la prévision du comportement catalytique. L’étape de transmétallation entre le bore et le nickel a été étudiée en détail à l’aide de méthodes expérimentales variées (electrochimie, RMN, cinétiques) et par DFT, permettant d’expliquer certaines limitations rencontrées par les experimentateurs. La seconde partie de cette thèse est dédiée à la rationalisation du comportement d’une famille d’acides de Lewis : les sels de triflate et de trif
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5

Lobrégat, Virginie. "Immobilisation d'organobores sur resines ioniques et reaction multi-composants pour la synthese de macrocycles par couplage de suzuki-miyaura." Rennes 1, 2000. http://www.theses.fr/2000REN10063.

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Ce memoire traite de l'immobilisation d'organobores sur des resines ioniques et de l'utilisation de reactions multi-composants pour la synthese de macrocycles par couplage de suzuki-miyaura decrochant. Dans un premier temps, des acides aryl et vinylboroniques ont ete quaternarises et immobilises sur des resines ioniques de type dowex a contre ion hydroxyle, sous la forme de borates effectuant l'etape de transmetallation dans le couplage de suzuki-miyaura. Le greffage peut etre controle par rmn 1 1b et 1 3c dans des conditions standard. Les supports reactifs ont ete engages dans des couplages d
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6

Peramo, Arnaud. "Modification sélective de protéines en milieu biologique par réaction de Suzuki-Miyaura nanocatalysée PLGA-PEG-supported Pd nanoparticles as efficient catalysts for Suzuki-Miyaura coupling reactions in water Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles A Self-Assembling Palladium-Loaded Calixarene as a Potent Catalyst for the Suzuki-Miyaura Cross-coupling Reaction in Water." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS600.

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Les nanotechnologies ont ouvert de nouvelles perspectives pour l’administration ciblée des médicaments. Les approches actuelles en nanomédecine sont basées sur l’encapsulation d’un principe actif dans un nano-vecteur. Nous proposons dans ce travail l’utilisation de nanoparticules non plus pour adresser un médicament encapsulé vers sa cible, mais pour manipuler une protéine d’intérêt en milieu biologique, ce qui constitue une nouvelle stratégie thérapeutique. Avec cet objectif, nous avons identifié une formulation de nanoparticules de palladium, stable, non toxique et dotée d’un pouvoir catalyt
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7

Alrawashdeh, Albara I. S. "From Mono- to Tetraphosphines – A Contribution to the Development of Improved Palladium Based Catalysts for Suzuki- Miyaura Cross Coupling Reaction." Doctoral thesis, Universitätsbibliothek Chemnitz, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-80110.

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Im ersten Teil der Arbeit wird die Synthese neopentyl- und neosilylsubstituierter Phosphane zur Verwendung als Liganden in katalytisch aktiven Palladiumkomplexen beschrieben. Die Aktivität wurde in der Suzuki-Miyaura Kreuzkupplungsreaktion getestet. Während die neosilylsubstituierten Phosphane 2:1 Addukte (5b und 5d) mit geeigneten Palladiumsalzen bilden, welche moderate Katalyseaktivität zeigen, untergehen die neopentylsubstituierten Komplexe schnelle Cyclometalierungsreaktionen in Gegenwart von Basen und bilden die katalytisch wenig aktiven Palladacyclen (6a, 6e, and 6g). Die deaktivierende
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8

Green, Anthony Laine. "The Directed ortho Metalation of pyridine derivatives with in situ boronation and links to the Suzuki-Miyaura cross coupling reaction." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ63310.pdf.

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9

Balanta, Castillo Angelica. "Novel molecular and colloidal catalysts for c-c bond formation processes." Doctoral thesis, Universitat Rovira i Virgili, 2011. http://hdl.handle.net/10803/66243.

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Esta tesis doctoral se centró en la síntesis y la caracterización de nanopartículas metálicas (Pd, Ni, Pt) estabilizadas por varios tipos de ligandos y el uso de estas nanopartículas en reacciones de formación de nuevos C-C o C-heteroatomo: a) Reacción de substitución alílica catalizadas por Pd; b) Reacción de acoplamiento asimétrico de Suzuki-Miyaura; c) Reacción de acoplamiento de Suzuki-Miyaura; d) reacción de adición 1,4 de ácidos borónicos a cetonas. En cada una de estas reacciones se llevó a cabo la síntesis y caracterización de nanoparticulas metálica y complejos moleculares usando muc
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10

Cerezo, Frias Vanessa. "Síntesi de base sòlida de pèptids biarílics contenint 5-arilhistidines." Doctoral thesis, Universitat de Girona, 2009. http://hdl.handle.net/10803/8054.

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Els aminoàcids biarílics es troben en una àmplia varietat de pèptids naturals amb important activitat biològica. Concretament, les arilhistidines formen part de les aciculitines, pèptids amb activitat citotòxica i antifúngica, La reacció de Suzuki-Miyaura és el mètode més versàtil per obtenir biarils assimètrics, encara que, fins el moment, no s'havia aplicat per a l'arilació de l'imidazole de la histidina. L'objectiu general d'aquesta tesi fou demostrar que es podia arilar l'imidazole de la histidina en fase sòlida mitjançant una reacció de Suzuki-Miyaura. En primer lloc, es sintetitzaren 4(5
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11

Korb, Marcus. "Anionic Phospho-Fries Rearrangements for the Synthesis of Planar-Chiral Ferrocenes and their Application in (atropselective) Suzuki-Miyaura Reactions." Doctoral thesis, Universitätsbibliothek Chemnitz, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-229081.

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The present PhD thesis describes the synthesis and characterization of novel planarchiral 1,2-P,O-ferrocenes and their application in the Pd-catalyzed Suzuki-Miyaura reaction. It was especially focused on the development of a new synthetic pathway to this type of substitution pattern by applying the anionic phospho-Fries rearrangement in ferrocene chemistry. Starting from hydroxy ferrocene, a high diversity of Fc–O–P- type (Fc = (n5-C5H5)(n5-C5H4)) compounds were synthesized, whereby the electronic properties of the phosphorus fragments were varied. The anionic phospho-Fries rearrangement succ
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12

Ng, Choi I.-teng Montserrat. "Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins." Doctoral thesis, Universitat de Girona, 2015. http://hdl.handle.net/10803/380739.

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The incorporation of unsymmetrical biaryl systems into peptide sequences is a strategy that can improve their biological activity. Due to the difficulty of arylating the 4(5}-position of the imidazole ring, this doctoral thesis was focused on the development of efficient methodologies for the solid-phase synthesis of 5-arylhistidine-containing antimicrobial undecapeptides through a Suzuki-Miyaura reaction under microwave irradiation. The extension of this protocol allowed the preparation of biaryl cyclic peptides of different ring sizes bearing a His-Phe or His-Tyr biaryl linkage. Then, it was
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13

Afonso, Afonso Ana. "Pèptids biarílics a partir de 4-iodofenilalanina o 3-iodotirosina per borilació i reacció de Suzuki-Miyaura en fase sòlida. Avaluació de l'activitat antimicrobiana." Doctoral thesis, Universitat de Girona, 2011. http://hdl.handle.net/10803/38882.

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En aquesta tesi doctoral es va estudiar la preparació de pèptids biarílics en fase sòlida. En primer lloc, es varen borilar residus de fenilalanina o tirosina presents a la seqüència peptídica a través d’una reacció de Miyaura. A continuació, es varen arilar els boronats resultants a través d’una reacció de Suzuki-Miyaura sota irradiació de microones, utilitzant diversos halurs d’aril i haloaminoàcids. La metodologia trobada es va estendre a la preparació de pèptids biarílics cíclics. Aquesta aproximació presenta l’avantatge d’evitar la síntesi en dissolució i la purificació del boronoaminoàci
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14

D'Attoma, Joseph. "Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10243.

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Les lymphomes à grandes cellules anaplasiques ou ALCL (Anaplastic Large-Cell Lymphoma) sont des cancers appartenant à la famille des lymphomes de type non-Hodgkin. La majorité des ALCL est issue d'une translocation t(2;5)(p23;q35) donnant lieu à la formation d'une protéine de fusion appelée NPM-ALK. A ce jour, peu d'inhibiteurs présentent de bonnes activités contre cette protéine chimérique. L'obésité représente un problème socio-médical d'envergure, à la fois pour ses effets directs et indirects ; le surpoids étant un facteur primaire dans de nombreuses maladies, tout particulièrement les dia
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15

Silva, Maurício Chagas da. "Estudo teorico do mecanismo de acoplamento-cruzado envolvido na reação de formação da ligação Ph-Ph catalisada por paladio via PhB (OH)2 (Ph=C6H5)." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248946.

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Orientador: Nelson Henrique Morgon<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-04T16:59:18Z (GMT). No. of bitstreams: 1 Silva_MauricioChagasda_M.pdf: 1448929 bytes, checksum: 5e8a626133912c0e72a209eeccbbfd34 (MD5) Previous issue date: 2005<br>Mestrado<br>Físico-Química<br>Mestre em Química
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Liebold, Claudia. "Immobilisierung von Palladium mittels 1,4-Bis-(4‘-pyrazolyl)benzen und dessen Anwendung in der heterogenen Katalyse." Doctoral thesis, Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2013. http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-124709.

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Die Immobilisierung homogener Katalysatoren ist eine wichtige Methode zur Realisierung der Abtrennbarkeit und Wiederverwendbarkeit aktiver Spezies. Im Rahmen dieser Arbeit wurde durch die Komplexierung von Palladium mit 1,4-Bis-(4′-pyrazolyl)benzen ein neues mikroporöses Koordinationspolymer generiert und dieses als heterogener Katalysator in der Suzuki-Miyaura-Kreuzkupplungsreaktion erfolgreich eingesetzt. Dabei konnten vollständige Umsätze und hohe Selektivitäten erzielt werden, die vergleichbar zu bereits kommerziell erhältlichen homogenen Katalysatoren sind. Die Besonderheit des Katalysato
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17

Heidemann, Sven. "Untersuchungen zur enantioselektiven Totalsynthese von Parnafungin C." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7C16-4.

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18

Abou, Hamdan Hussein. "Synthèse de nouveaux agents anticancéreux." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF012.

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Les cancers représentent un problème majeur de santé public d'où la nécessité de rechercher de nouvelles classes de médicaments. Parmi les pistes pour développer de nouveaux traitements, deux ont retenu notre attention et celle de nos collaborateurs : la modulation de l’épissage par des composés comme le NVS-SM2, et l’inhibition de l’oncogène KRAS par des dérivés de produits naturels, les flavaglines. Dans ce contexte, nous avons développé la première synthèse robuste du NVS-SM2, qui peut satisfaire la demande globale de cet agent pour examiner en détail son potentiel thérapeutique dans différ
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19

Souza, Pâmella Santos de. "Estudo da reação de modificação do poli(cloreto de vinila) com nucleófilos nitrogenados e das aplicações como suporte em reações de acoplamento." Universidade do Estado do Rio de Janeiro, 2015. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8526.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Neste trabalho foi realizada a modificação química do poli(cloreto de vinila) (PVC) pela sua reação com azida de sódio, onde alguns dos seus átomos de cloro foram substituídos por azidas. Em seguida o grupo incorporado foi transformado em triazóis por uma reação de cicloadição 1,3 entre o polímero modificado e propiolato de etila, sendo a reação catalisada por iodeto de cobre. Essas reações foram conduzidas sob aquecimento convencional e empregando irradiação de micro-ondas. Inicialmente, a reação incorporou 20% de triazol no PVC,
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20

Alrawashdeh, Albara I. S. [Verfasser], Heinrich [Akademischer Betreuer] Lang, Heinrich [Gutachter] Lang, and Wolfgang [Gutachter] Weigand. "From Mono- to Tetraphosphines – A Contribution to the Development of Improved Palladium Based Catalysts for Suzuki- Miyaura Cross Coupling Reaction / Albara I. S. Alrawashdeh ; Gutachter: Heinrich Lang, Wolfgang Weigand ; Betreuer: Heinrich Lang." Chemnitz : Universitätsbibliothek Chemnitz, 2011. http://d-nb.info/1214008410/34.

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21

Milde, Bianca. "(Ethynyl-)Ferrocenyl Phosphine Palladium Complexes and (Bis-)Phosphinoimidazol(e/ium) Compounds and their Application in Homogeneous Catalysis." Doctoral thesis, Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-90521.

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Die vorliegende Dissertation beschäftigt sich mit der Synthese, der Charakterisierung und der Anwendung neuartiger Phosphane in homogenkatalytischen Reaktionen. Dabei wurden die Ferrocenyl- und Ferrocenylethinylphosphan-Palladium und Ferrocenylethinylphosphan-Ruthenium Komplexe in der Palladium-vermittelten Mizoroki-Heck- und Suzuki-Miyaura-Reaktion sowie der Ruthenium-katalysierten Synthese von β-Oxopropylestern verwendet. Der Schwerpunkt lag dabei auf der Untersuchung des Einflusses der elektronischen und räumlichen Eigenschaften der Phosphanliganden auf die Aktivität und Produktivität der e
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22

Adidou, Ouissam. "Ligands dérivés de saccharides et, ou supportés par un bras poly(éthylène) glycol : synthèse et applications en catalyse organométallique." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10171.

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La synthèse de deux familles de ligands a été envisagée. La première famille de ligands concerne la préparation de nouveaux ligands dérivés de la D-glucosamine ou du D-glucose qui seront engagés dans la réaction de substitution allylique de type Tsuji-Trost en phase homogène. La deuxième famillede ligands concerne la préparation de ligand supportés par un bras poly(éthylène) glycol et dérivés dela D-glucosamine ou de la di-(2-pyridyl)méthylamine. Ces ligands hydrosolubles ont été engagés dans deux réactions pallado-catalysées en phase aqueuse à savoir la substitution allylique de type Tsuji-Tr
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Eriksson, Ludvig. "Transition Metal Mediated Transformations of Carboranes." Doctoral thesis, Uppsala University, Organic Chemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3324.

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<p>This thesis describes the use of copper and palladium to mediate transformations of carboranes, especially <i>p</i>-carborane.</p><p>1-(1-<i>p</i>-carboranyl)-<i>N</i>-methyl-<i>N</i>-(2-butyl)-3-isoquinolinecarboxamide, a carborane containing analogue of the peripheral benzodiazepine receptor (PBR) ligand PK11195, has been synthesised. A key step in the reaction is the copper (I) mediated coupling of p-carborane with ethyl 1-bromo-isoquinoline-3-carboxylate. </p><p><i>p</i>-Carborane has been arylated on the 2-<i>B</i>-atom in high yields, using the Suzuki–Miyaura reaction. Thus the reacti
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24

Karabiyikoglu, Sedef. "Synthesis Of Ferrocenyl Substituted Pyrazoles By Sonogashira And Suzuki-miyaura Cross-coupling Reactions." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612139/index.pdf.

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Pyrazoles constitute one of the most important classes of heterocyclic compounds due to their interesting chemical and biochemical features. Researchers have studied many pyrazole containing structures for almost over a century in order to investigate the various biological activities possessed by these molecules. A new and important trend in these studies is to produce ferrocenyl substituted pyrazoles since ferrocene attracts considerable interest in the research field of organometallic and bioorganometallic chemistry because of its valuable chemical characteristics like high stability, low t
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25

Kuleshova, Olena. "2-azahetaryl-3-enaminonitriles cycliques pour la synthèse d'azahétérocycles fonctionnalisés, la complexation de métaux et la conception de sondes optiques." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30127/document.

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Les recherches effectuées au cours de ce travail de thèse sont centrées sur les dérivés cycliques de type 2-azahetaryl-3-énaminonitrile qui représentent une structure d'intérêt du fait de son nombre élevé de sites réactifs potentiels. La fonctionnalisation régiosélective de chaque site donne en effet accès à des une grande diversité structurelle de composés azoté et substitué par un azahétérocycle. Un atout majeur des 2-azahetaryl-2-(1-R-pyrrolidin-2-ylidene)acétonitriles est leur grande accessibilité à partir de matières premières simples et bon marché. Nous avons pu étudier leur emploi dans
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Keith, Adam J. "Ion-tagged Phosphines for Catalytic Reactions in Ionic Liquids." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1407960203.

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Sun, Lijie. "Synthesis of atropisomeric 1-Naphthamide-Derived phosphines and application for asymmetric heck and Suzuki-Miyaura reactions /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202009%20SUN.

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Lu, Zhe. "Nickel-catalyzed Suzuki-Miyaura reactions of unactivated halides with alkyl boranes and planar-chiral borabenzene catalysts for Diels-Alder reactions." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62101.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Part I describes the expansion in scope of a nickel-catalyzed coupling reaction of unactivated alkyl bromides and alkyl boranes to include unactivated alkyl chlorides. The new method is adapted for use outside of a glove box and is also found to be applicable not only to the coupling of primary chlorides, but also to the coupling of bromides and iodides, both primary and secondary. ... This coupling reaction of chlorides is
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Damon, Eldon Pierre. "Green synthesis: the use of brown algae in the synthesis of palladium nanoparticles and applications in carbon – carbon bond formation reactions." University of the Western Cape, 2020. http://hdl.handle.net/11394/7721.

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>Magister Scientiae - MSc<br>Due to the negative impact on the environment and the associated biological risks on human and animal life, the need for eco-friendly synthetic protocols is critical. With the rapid advancement in nanotechnology, this extends to the synthesis of nanomaterials. Eco-friendly nanoparticle synthesis protocols have led to the use of fungi, plants and other biological substances, due to their remarkable ability in reducing metal ions. This led to the formation of very efficient hybrid catalysts, which are partially organic/inorganic composites. Palladium nanoparticles ha
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López, Viveros Melissa. "Influence des propriétés d'un réseau polymère sur la synthèse in situ de nanoparticules de palladium : application aux membranes catalytiques de grande efficacité en chimie fine." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30284.

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Des membranes polymères catalytiques ont été préparées via la polymérisation photo-amorcée de monomères acryliques à la surface de membranes support MicroPES(r). Des nanoparticules de palladium (PdNP) avec diamètre moyen compris entre 4 et 10 nm sont ensuite synthétisés et immobilisées dans ces gels polymères greffés. Cette thèse se focalise sur le greffage d'un gel de polymère neutre : (2-hydroxyethyl acrylate) (PHEA), pour négliger les contributions ioniques du réseau polymère sur la synthèse in-situ des PdNP. La stabilisation de PdNP dans le gel de PHEA greffé est possible par des moyens st
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Naas, Mohammed. "Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2009/document.

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L’accès à de nouveaux composés hétérocycliques originaux biologiquement actifs nécessite la mise au point de nouvelles méthodes de synthèse rapides et efficaces. Dans ce contexte, nous nous sommes intéressés à la réactivité des indazoles. Dans la première partie, nous avons étudié la sélectivité des couplages de type Suzuki, pour fonctionnaliser la position 3 d’indazoles possédant la fonction NH libre. Par la suite, un nouveau procédé d’(hétéro)arylation direct pallado-catalysé régiosélectif a été mis à profit pour synthétiser des indazoles fonctionnalisés tant sur la position 3 que sur le som
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Ben, Halima Taoufik. "Engaging Esters as Cross-Coupling Electrophiles." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39493.

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Cross-coupling reactions, where a transition metal catalyst facilitates the formation of a new carbon-carbon or carbon-heteroatom bond between two coupling partners, has become one of the most widely used, reliable, and robust family of transformations for the construction of molecules. The Nobel Prize was awarded to pioneers in this field who primarily used aryl iodides, bromides, and triflates as electrophilic coupling partners. The expansion of the reaction scope to non-traditional electrophiles is an ongoing challenge to enable an even greater number of useful products to be made from simp
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Korb, Marcus [Verfasser], Heinrich [Akademischer Betreuer] Lang, Heinrich [Gutachter] Lang, and Klaus [Gutachter] Banert. "Anionic Phospho-Fries Rearrangements for the Synthesis of Planar-Chiral Ferrocenes and their Application in (atropselective) Suzuki-Miyaura Reactions / Marcus Korb ; Gutachter: Heinrich Lang, Klaus Banert ; Betreuer: Heinrich Lang." Chemnitz : Universitätsbibliothek Chemnitz, 2017. http://d-nb.info/1214377661/34.

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Pareek, Manish [Verfasser], Martin [Akademischer Betreuer] Oestreich, Martin [Gutachter] Oestreich, and Philipp [Gutachter] Heretsch. "Activation of boron–boron, tin–silicon, and tin–tin bonds : application in carbon–element (E = B and Sn) bond-forming reactions and site-selective Suzuki–Miyaura cross-coupling reactions / Manish Pareek ; Gutachter: Martin Oestreich, Philipp Heretsch ; Betreuer: Martin Oestreich." Berlin : Technische Universität Berlin, 2017. http://d-nb.info/1156016843/34.

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35

Grosse, Sandrine. "Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique." Thesis, Orléans, 2013. http://www.theses.fr/2013ORLE2056.

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Les imidazo[1,2-b]pyrazoles tout comme les imidazo[1,2-a]imidazoles sont des entités présentant diverses applications intéressantes notamment dans le domaine pharmacologique. Cependant, malgré ce potentiel, ces structures hétérobicycliques ont été, jusqu’à ce jour, relativement peu étudiées tant au niveau de leur préparation que de leur fonctionnalisation. De ce fait, ces travaux de thèse ont pour objet la mise au point de nouvelles voies d’accès à ces systèmes bicycliques et ce, au départ de substrats facilement accessibles. Des stratégies de fonctionnalisation de ces charpentes moléculaires
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36

Le, Meur Mikaël. "Identification de nouveaux inhibiteurs de l’agrégation de la protéine Tau." Thesis, Orléans, 2014. http://www.theses.fr/2014ORLE2046.

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Parmi la vingtaine de pathologies neurodégénératives recensées à ce jour, il a été retrouvé des caractéristiques communes telles que des lésions neuronales. Dans le cas de la Maladie d’Alzheimer, une dégénérescence neurofibrillaire a notamment été mise en évidence, ce qui se traduit par l’agrégation de protéines Tau anormalement modifiées. Bien que les mécanismes moléculaires impliqués demeurent encore mal compris, nous nous sommes intéressés, au cours de cette thèse, à la synthèse puis à l’évaluation biologique de nouveaux inhibiteurs de l’agrégation de la protéine TAU impliquée dans la Malad
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37

Mitchell, Emily. "Studies In the Optimization of the Suzuki-Miyaura Reaction." Thesis, 2008. http://hdl.handle.net/1974/1612.

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Enormous efforts have been made to optimize the Pd-catalyzed Suzuki-Miyaura reaction, but there is to date no generally useful protocol and forcing conditions are often required. One reaction variable that has often been neglected is the extent to which the supposed catalysts, bisphosphinepalladium(0) complexes, are actually formed from the variety of popular precatalysts used. There is in fact little evidence that these precursors produce bis-ligated Pd(0) complexes and it is possible that the rate limiting factor may be catalyst formation. If so, then the development of an optimized method
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38

Liu, Shi-hao, and 劉士豪. "Stereoselective Glycosylation of exo-galactal by Suzuki-Miyaura reaction and Mitsunobu reaction." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/79414950977383047856.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>99<br>Herein we report C-arylglycosylation and O-glycosylation of exo-glycals, in which two products are generated in association with Suzuki-Miyaura reaction and Mitsunobu reaction C-arylglycosides were synthesized in moderate to good yields by reaction of exo-glycals and arylboronic acids in the presence of 0.5 equiv. Pd(OAc)2. The C-arylglycosylation reaction of a aryl-Pd complex to exo-glycals double bond followed by syn elimination of HPd(OAc) to provide a carbon-Ferrier type product. Mitsunobu reagent mediated O-glycosylation of exo-glycals have been carried
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39

Chang, Chia-Wen, and 張佳雯. "Stereoselective Suzuki-Miyaura Reaction of 2-C-hydroxymethyl glycalswith Arylboronic Acids." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/15601437473222137855.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>100<br>We applied the Suzuki-Miyaura reaction of 2-C-hydroxymethyl glucal with various arylboronic acid bearing an alkyl, alkoxy, cholor, and ester groups at the para position in the presence of 0.5 equiv of palladium(II) acetate. The glycosyl additions gave the high stereoselective β-C-aryl glycosides and were complete in 1 h in 63–83% yield. However, when we applied this method to 2-tolyboronic acid, 2-methoxyphenylboronic acid, and 2-bromophenylboronic acid, the corresponding β-C-aryl glycosides cannot be obtained and the α-C-aryl glycosides was found in 62-72%
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40

Chen, Chuan-Lin, and 陳傳霖. "Substituent Effect on Cyclopalladation of Arylimine Ligands Applied for Suzuki-Miyaura Coupling Reaction." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/84490813805942089652.

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博士<br>國立臺灣大學<br>化學研究所<br>92<br>A series of substituted benzylidene- and dialkylarylamines reacted with PdCl2(CH3CN)2 under basic conditions at the room temperature to provide the desired cyclopalladated products (13a-i and 14j-m), even the halo substituted (Le and Lf) arylimines. The steric bulky substituent such as t-butyl on the aryl rings readily inhibits the C-H activation and only yields the simple imine-coordinated complexes (15g and 15g’, 15h). As expected, cyclometallation takes place at the ortho position of the aryl ring resulting in formation of a five-membered chelating ring. Howev
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41

Chiang, Yun-Ting, and 蔣昀廷. "Synthesis, Characterization and Catalytic Application of Novel Palladium-Carbodicarbene Complexes in Suzuki-Miyaura Reaction." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/d3yua4.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>105<br>Carbodicarbene so called as bent allene is a divalent carbon (0) or carbon supported by two N-heterocyclic carbene (NHC). It is a strong electron donor ligand for supporting many metal complexes. In this thesis, we reported a preparation of unsymmetrical carbodicarbene via SN2 reaction. We also prepared a series of novel carbodicarbene palladium complexes bearing a different phosphine or pyridine derivatives ligands. The single crystal X-ray structural analysis and spectroscopic studies have been used to understand the trans/cis isomeric behavior of the comp
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42

Wang, Meng-Pei, and 王孟珮. "The Development of Novel Benzimidazolylindole-scaffold Ligands and Their Applications in Suzuki-Miyaura Coupling Reaction." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/02203407971141139644.

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碩士<br>國立中興大學<br>化學系所<br>104<br>Suzuki-Miyaura coupling reaction has played an important role in the synthesis of biaryl compounds. Unfortunately, most of them require the use of air and/or thermally labile phosphine ligands. How to improve the ligand stability and to reduce the amount of catalyst needed has been one of the important synthetic issues. This research has synthesized a series of novel C,N-ligands 17, 20 comprising indole and benzimidazole rings starting from commercially available phenyl diamine and indole 2-carboxylic acid. The Suzuki cross-coupling reaction of functionalized
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43

Lin, Yi-Ren, and 林湙人. "The Study of Bis-benzimidazolium Salts in Suzuki-Miyaura Coupling Reaction and Asymmetric C-C Formation." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/56345569335107024775.

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碩士<br>國立中興大學<br>化學系所<br>104<br>Recently, the N-heterocyclic carbene based Pd catalysts (Pd–NHC) have been widely used in the Suzuki coupling reaction. However, most of the ligands are less reactive in aqueous media. Therefore, organic solvent is required to be used for these reactions. In addition, the biaryl moiety is a central part in the structure of many natural products and drugs, therefore, the synthesis of biaryl structure has been an important topic in organic synthesis. The bis-benzimidaolium salts 78 have been successfully synthesized from commercially available and inexpensive o-
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44

Chang, Yen-Yu, and 張晏瑜. "Preparation and Application of Indolyl Secondary Phosphine Oxides in Palladium Complexes Catalyzed Suzuki-Miyaura Cross-coupling Reaction." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/92593863878119276945.

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碩士<br>國立中興大學<br>化學系所<br>99<br>Several new indolyl secondary phosphine oxides C8NP(=O)(tBu)(H) (4a), MeC8NP(=O)(tBu)(H) (4b), and PhC8NP(=O)(tBu)(H) (4c) were prepared. The molecular structures of (C8N)2P(tBu) (3a&apos;&apos;), PhC8NPCl(tBu) (3c), PhC8NP(=O)(tBu)(H) (4c) and [(4a&apos;&apos;)(4a&apos;&apos;-H+)Pd(μ-Cl)]2 (5a) were determined by single-crystal X-ray diffraction methods. The structure of palladium complex is stabilized by the indolyl scafford. In addition, secondary phosphine oxides were air- and moisture-stable preligands and advantageous for the purpose of storage. In this work
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45

Pradeep, Priyamvada. "The suzuki-miyaura cross coupling reaction as a key step for the synthesis of oxygen and nitrogen containing hetero-aromatic compounds." Thesis, 2016. http://hdl.handle.net/10539/19363.

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A thesis submitted to the Faculty of Science University of the Witwatersrand Johannesburg In fulfilment of the requirements for the Degree of Doctor of Philosophy June 2015<br>The first two chapters of this thesis deals with the synthesis of 6H-benzo[d]-naphtho[ 1,2- b]pyran-6-one motif found in gilvocarcin as well as related aromatic compounds containing the aromatic pyranone moiety. The synthesis was undertaken by employing the Suzuki- Miyaura cross coupling reaction and a novel N-bromosuccinimide induced ring cyclization reaction to afford the pyranone. It was established that the
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46

WANG, WAN-RONG, and 王婉蓉. "N-heterocyclic Carbene Palladium Complexes for Suzuki-Miyaura Coupling Reaction with Benzyl Chloride and Aromatic Boronic Acid Leading to Diaryl Methanes." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/34fa3g.

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47

Yunker, Lars Peter Erasmus. "Real-time mass spectrometric analysis of catalytic reaction mechanisms." Thesis, 2017. http://hdl.handle.net/1828/8029.

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Mass spectrometry was used to study two disparate transformations: in an applied project, the supposed degradation of perfluorooctanesulfonate (PFOS); and in a fundamental study, the Suzuki-Miyaura (SM) reaction was investigated in detail. The first investigation revealed that published methods to degrade PFOS were ineffectual, with apparent decreases being associated with adsorption onto available surfaces. In the Suzuki-Miyaura reaction, a dynamic series of equilibria were observed, and there is no direct evidence of a single pathway. Instead, there appear to be two mechanisms which are acti
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48

HUNG, YING-CHI, and 洪英棋. "One-pot Reaction for the Synthesis of Flavones via Oxidation of Flavanones and Selective Suzuki-Miyaura Reaction to 3- and 4-Bromocoumarins Catalyzed by Water-soluble Palladium Catalyst." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/hews7c.

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碩士<br>國立臺北科技大學<br>分子科學與工程系有機高分子碩士班<br>107<br>The dissertation comprises two subjects. In the first subject, we designed a Pd(OAc)2/cationic 2,2’-bipyridyl-catalytic system to catalyzed conjugate addition of chromones and arylboronic acids forming flavanone derivatives as the first step of one-pot reaction, in second step adding iodine which undergoes oxidation of flavanone to obtain flavone product. Then the foregoing flavone derivatives proceeded with demethylation to acquire flavone nature products and medical potential flavone derivatives. In the second subject, our research was aimed to ex
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49

Oyeyiola, Felix Adetunji. "Synthesis and transformation of the 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones." Diss., 2011. http://hdl.handle.net/10500/5842.

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The 2-aryl-2,3-dihydroquinolin-4(1H)-ones were prepared via acid-catalyzed cyclization of the corresponding 2-aminochalcones, which were in turn, prepared by base-promoted Claisen-Schmidt aldol condensation of 2-aminoacetophenone and benzaldehyde derivatives. The 2-aryl-6,8-dibromo-2,3-dihydroquinolin-4(1H)-ones were prepared by reacting 2-aryl-2,3-dihydroquinolin-4(1H)-ones with N-bromosuccinimide (NBS) in carbon tetrachloride-chloroform mixture at room temperature. The 2-aryl-6,8-dibromo-2,3-dihydroquinolin-4(1H)-ones were subjected to palladium-catalyzed Suzuki-Miyaura cross-coupling reacti
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50

Shih, You-Cheng, and 石祐承. "The novel triptycene-incorporated N-heterocyclic carbenes catalyzed Suzuki-Miyaura coupling reaction and application of chiral triptycene-incorporated gold complexes into the use of asymmetric 1,6-enyne cycloisomerization." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/6rr8y5.

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碩士<br>國立東華大學<br>化學系<br>100<br>Palladium homogeneous catalysis is known as a versatile tool for carbon–carbon bond formation in organic synthesis. The Suzuki–Miyaura coupling reaction of aryl halides with arylboronic acids is one of the most important palladium-catalyzed cross-coupling reactions. We use the 2,6-bis(bromomethyl)pyridine and the imidazole corporated with triptycene to make a CNC pincer, then being a ligand to catalyze the Suzuki coupling reaction with the palladium. We found the ligand 1-di is an active catalytic ligand which can giving the good results to react with aryl hal
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