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Dissertations / Theses on the topic 'Synthesis of 5-methyltetrazole derivatives'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Chornous, V. O. "5-carbofunctionalized imidazoles and their derivatives: synthesis and biomedical investigation." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/16859.

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2

Flynn, Bernard L. "The synthesis and palladium-catalysed coupling of 5-Trifluoromethanesulfonyluridine derivatives /." Title page, contents and abstractn only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phf648.pdf.

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3

Sullivan, Shannon M. "Synthesis of 2,4-disubstituted pyrimidine derivatives as potential 5-HT7 receptor antagonist." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-05052008-153400/.

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Thesis (M.S.)--Georgia State University, 2008.<br>Title from file title page. Lucjan Strekowski, committee chair; A.L. Baumstark, Gabor Patonay, Doyle Barrow , committee members. Electronic text (68 p. : ill.) : digital, PDF file. Description based on contents viewed June 23, 2008. Includes bibliographical references (p. 42-430.

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4

Kayalar, Metin. "Synthesis Of 1,2,3,5-tetrasubstituted Pyrrole Derivatives Via 5-exo-dig Type Cyclization And Stereoselective Functionalisation Of Ferrocene Derivatives." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12605757/index.pdf.

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ABSTRACT SYNTHESIS OF 1,2,3,5-TETRASUBSTITUTED PYRROLE DERIVATIVES VIA 5-EXO-DIG TYPE CYCLIZATION AND STEREOSELECTIVE FUNCTIONALISATION OF FERROCENE DERIVATIVES Metin Kayalar M.S., Department of Chemistry Supervisor: Prof. Dr. Ayhan S. Demir January 2005, 102 pages A convenient and new method for the synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives starting from 1,3,-dicarbonyl compounds through acid catalyzed cyclization reaction is described. Alkylation of 1,3-dicarbonyl compound with propargyl bromide followed by one step cyclization with the introduction of primary amines in

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5

Yang, Min. "Synthesis of 5 thioglucose derivatives in the carbohydrate metabolic pathways in lactic acid bacteria." Thesis, University of Huddersfield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274227.

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6

Radzey, Hanna Agnes. "Synthesis of fluorescent toxin and nucleotide derivatives to specifically address membrane proteins." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://hdl.handle.net/11858/00-1735-0000-0022-6055-5.

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7

Shelton, Jadd R. "Synthesis and Biological Evaluation of Various Derivatives of a Broad-Spectrum Anticancer Nucleoside." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3743.

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Recently the Peterson lab discovered a promising anticancer adenosine derivative-- 2´,3´-bis-O-tert-butyldimethylsilyl-5´-deoxy-5´-[N-(methylcarbamoyl)amino]-N6-(N-phenylcarbamoyl)adenosine. This compound showed selective toxicity against human colon cancer cells in vitro with LC50's = 6--10 µM. It was hypothesized that the lead compound exerted its cytotoxic effects by interacting with a protein kinase. A systematic Structure Activity Relationship (SAR) was undertaken in an attempt to increase the kinase-binding affinity of the lead compound. Many regions of the lead compound were examined: t

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8

Oliveira, Marcelio. "Synthesis and Evaluation of N6,5'-Bis-Ureido-5'-Amino-5'-Deoxyadenosine Derivatives: Novel Nucleosides with Antiproliferative and Protein Kinase Binding Activities." Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd3231.pdf.

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9

Bhat, Shreesha V. "Synthesis of 1,2,4 oxadiazol-5-imine, 1,2,4-triazol-3-imine and derivatives : a substituted cyanamide-based strategy for heterocycle synthesis." Thesis, University of Lincoln, 2017. http://eprints.lincoln.ac.uk/28632/.

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Considering the importance of nitrogen-rich heterocycles in drug discovery, a novel strategy towards heterocycle synthesis was envisioned using cyanamide chemistry. Synthesis which involve mild conditions, avoids multi-step sequence and non-toxic reagents are desirable for generation of large combinatorial libraries of drug molecules. We envisaged that the NCN linkage of the cyanamide as well as the concomitant use of the nucleo-and electrophilic centres of the cyanamide could provide a novel synthetic route towards nitrogen heterocycles. The first part (Ch-2) constitute the bulk of the thesis

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10

Bratenko, M. K. "Synthesis of potentially biologically active functional derivatives of 3- [5- (4-nitrophenyl) -2-furyl] -4-pyrazolecarbaldehydes." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18518.

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11

Conde, Amanda Solis. "Synthesis of 5-methyl-3-phenyl-1,3,4-oxadiazol-2(3H)-one derivatives by electrophilic aromatic substitution." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1547584724393162.

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12

Piper, Colin. "Synthesis and structural study of functionally substituted #eta#'5-cyclopentadienyl derivatives of transition and main group metals." Thesis, Coventry University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281883.

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13

Altundas, Abdullah Bilal. "Synthesis of XZH-5 Derivatives as Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) and Synthesis of π-Extended Tetraphenylporphyrins". Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1473201129.

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14

Oberoi, Sonia. "Synthesis and Characterization of Thin films of Novel Functionalised 2,5-Dithienylpyrrole Derivatives on Oxide Substrates." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1118754022012-45347.

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Conducting polymers find variety of application in many areas in microelectronics. PPY and PT are among the most extensively studied intrinsically conducting polymers. The problem of poor adhesion of the electrochemically deposited conducting polymers was the main focus of this work. This easy peeling of the PPY layer from the oxide substrate was circumvented by design of novel adhesion promoters, which compatibilise the two incompatible surfaces- the polymer film and the oxide substrate. The first part of the research was focused on the synthesis of different classes of adhesion promoters. Th

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15

Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyr

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16

Xia, Zuping. "Design, synthesis and biological evaluation of butanoate, retinoate and bis(2,2,2-trichloroethyl)phosphate derivatives of 5-fluoro-2'-deoxyuridine and 2',5-difluoro-2'-deoxyuridine." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0012/NQ29127.pdf.

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17

Bhattarai, Sanjay [Verfasser]. "Synthesis and structure-activity relationships of alpha,beta-methylene-ADP derivatives: potent and selective ecto-5′-nucleotidase inhibitors / Sanjay Bhattarai." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1077290330/34.

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18

Tang, Betty. "Synthesis of closomer derivatives of polyhedral boranes for use as drug delivery vehicles." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1779690201&sid=5&Fmt=2&clientId=48051&RQT=309&VName=PQD.

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19

Marin, Julien. "Enantiopure monohydroxylated delta-lactams as precursors of glycosylated 4- and 5-hydroxylysine derivatives : Application to the synthesis of glycopeptides derived from type II collagen." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. https://publication-theses.unistra.fr/public/theses_doctorat/2003/MARIN_Julien_2003.pdf.

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La polyarthrite rhumatoi͏̈de (PR) est une maladie autoimmune gravement invalidante qui affecte plus de 0. 5% de la population mondiale. L'arthrite expérimentale au collagène (AEC) est le modèle murin le plus répandu pour l'étude de cette maladie. En 1994, le groupe de Holmdahl a démontré que l'épitope T immunodominant dans l'AEC correspondait à un glycopeptide dérivé du collagène de type II (CII). Des études ultérieures réalisées par Holmdahl en collaboration avec le groupe de Khilberg ont permis de mettre en évidence que ce peptide correspondant à la séquence CII(256-270) contenait une lysine

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20

Annibaletto, Julien. "L'alkylidène de l'acide de Meldrum comme plateforme utile en réaction multicomposés organocatalysée Catalytic enantioselective syntheses of isoxazolidin-5-ones C5‐disubstituted Meldrum's acid derivatives as platform for the organocatalytic synthesis of c3‐alkylated dihydrocoumarins." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMIR19.

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L’objectif de cette thèse a été d’accéder à des hétérocycles chiraux, les isoxazolidin-5-ones, par le biais d’une réaction multicomposés organocatalysée impliquant un intermédiaire très réactif qui est l’alkylidène de l’acide de Meldrum. A l’aide de nucléophiles atypiques dérivés d’urée et d’un nouvel organocatalyseur dérivé du Quinquina, nous sommes parvenus à développer la première version énantiosélective organocatalysée de la réaction multicomposés de Knoevenagel/aza-Michael/Cyclocondensation permettant d’accéder aux isoxazolidin-5-ones β-substituées énantioenrichies. Une version diastéréo

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21

Fernandez, Anne-Marie. "Préparation de γ-butyrolactones γ-alkylées optiquement pures à partir de l'acide L-tartrique. Application à la synthèse totale de la L-bioptérine". Rouen, 1996. http://www.theses.fr/1996ROUES025.

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Une nouvelle méthode pour la préparation de gamma-butyrolactones optiquement pures est proposée. Une stratégie de synthèse donnant accès à deux types de chirons carbonylés (cétones et aldéhyde) a permis le développement de deux réactions hautement stéréosélectives créant ainsi un troisième centre stéréogénique : la réduction des cétones, (2R, 3R)-2,3-dipivaloxy-4-oxo alcanoates de méthyle par le borohydure de sodium dans le méthanol mène aux alcools correspondants (4R), avec des ee>98%, précurseurs des (2R,3S,4R)-2,3-dipivaloxy-4-alkylbutyrolactones. L'addition d'organomagnésiens sur l'aldéhyd

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22

Benaissa, Tahar. "Synthèse de ligands contenant un atome de fluor et pouvant donner des complexes à applications médicales : étude de la complexation de la 5-fluoro-8-hydroxyquinoline avec des cations métalliques, par RMN du fluor." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10100.

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Ce travail se place a la convergence de deux grands themes etudies au laboratoire: le marquage de molecules par un atome de fluor et l'etude de la complexation de cations metalliques par des ligands. La premiere partie concerne la preparation de deux series de ligands contenant du fluor: des biphenols et des composes contenant des groupements 2-fluoropyridines. Les biphenols substitues par deux ou quatre atomes de fluor (en position 4,4' ; 5,5' ; 4,4 ;,5,5') ont ete obtenus a partir de bromophenols par une reaction de type ullman. Leurs derives sulfones ont egalement ete prepares pour augmente

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23

Caton-Williams, Julianne Marie. "Synthesis and Enzymatic Studies of Selenium Derivatized Nucleosides, Nucleotides and Nucleic Acids." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_diss/42.

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Nucleoside 5-triphosphates are the building blocks to synthesis of nucleic acids. Nucleic acids (RNA and DNA) participate in many important biological functions in living systems, including genetic information storage, gene expression, and catalysis. Nucleoside 5- triphosphates have many important therapeutic and diagnostic applications. To understand how these triphosphates are utilized in living systems, numerous synthetic mimics have been prepared and used as active metabolites of certain drugs and molecular probes. Over the years, nucleic acids have been modified at the nucleobase, sugar m

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24

Cripe, M. Kathleen Leslie. "Syntheses and characterization of a t-OCTYLCALIX[5]ARENE derivatized capillary column for gas chromatography." Connect to online version at OhioLINK ETD Connect to online version at Digital.Maag, 1998. http://hdl.handle.net/1989/3749.

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25

Ciccolini, Cecilia. "Synthesis of Mono and Poly-Heterocycles starting from 1,2-Diaza-1,3-Dienes (or precursors) as Building Blocks." Doctoral thesis, Urbino, 2020. http://hdl.handle.net/11576/2674162.

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26

Leboho, Tlabo Caiphus. "Novel syntheses of 5- and 7- azaindole derivatives." Thesis, 2014.

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This thesis describes the application of the Sonogashira coupling reaction to access a variety of 5-and 7-azaindoles derivatives. The background chapter paints a picture about the importance of indole-containing compounds and azaindole-containing compounds. In this first chapter, discovery, synthesis, properties and reactivity of indole and azaindoles were explained.

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27

Hsieh, Ming-Chieh, and 謝明杰. "Synthesis and Cytotoxicity of 5-Substituted-2-Phenyl-4-Quinolone Derivatives." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/23365867866234330405.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>81<br>Recently, a series of 1, 6, 7, 8, and 4'-substituted-2- phenyl-4-quinolones were synthesized and examined for their cytotoxicity. Some of these compounds were found to possess significant cytotoxicity. Therefore, in this study, 4-phenyl-2-quinolone and a series of 5-substituted-2-phenyl-4-quinolone analogs were synthesized and evaluated for their cytotoxicity. When aniline was condensed wyth ethyl benzoylacetate followedby a thermal cy

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28

Chih-Wen, Su, and 蘇志文. "Synthesis of 5-Methyl-2-substituted-2H-pyrazol-3-yl-amine Derivatives." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/67023478991124518308.

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碩士<br>國立臺灣科技大學<br>纖維及高分子工程系<br>89<br>In this study, the reaction of acetoacetamide with hydrazine hydrate and phenyl hydrazine was shown to give compounds 3a and 3b. First, the reaction of compounds 7a~7b and 11a~11b with a solution of compounds 3a and 3b in water by nitrosation at position 4 in low temperature, and were coupled with aromatic benzylamine derivatives. Second, the reaction of compound 3a with ethyl acetoacetate, acetoacetamide, phthalic anhydride and nitric acid was shown to give compounds 17, 23, 27 and 30. Third, a solution of compound 3b in ethanol was condensed with aromatic

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29

Kourtidou, Maria. "Synthesis of 5-nitrosalicylanilide derivatives with potential antibacterial activity (Syntéza 5-nitrosalicylanilidových derivátů s potenciální antibakteriální aktivitou)." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-324957.

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Kourtidou Maria Synthesis of 5-nitrosalicylanilide derivatives with potential antibacterial activity Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Pharmacy Background: The aim of this diploma thesis was the synthesis of 5- nitrosalicylanilide derivatives as a potential anti-tuberculosis agent. Methods: The reactions were monitored, and the purity of products was verified by thin layer chromatography in which the plates were coated with silica gel 60 F254 and seen by using UV irradiation. Column chromatography was done using silica gel 60. The melting points

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30

Wu, Tsung-Han, and 吳宗翰. "Synthesis of 3-(5-Methyl-2-furyl)-1,5-diphenylpyrazole Derivatives as Antiplatelet Agents." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/66580816427067903733.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>97<br>In continuing development of novel aniplatelet agents, we had found that 3-(5-methyl-2-furyl)-1,5-diphenylpyrazole ( I) showed good platelet inhibitory activity. The mechanism is inhibition of cyclic nucleotide phosphodiesterase 5 (IC50 = 4.21 μM). Encouraged by this result, the compound I was selected as a lead compound and a series of 1,5- substituted diphenyl-3-(5-methyl-2-furyl)pyrazole derivatives (4-11, 13-18, 21-26, 28-33, 35-40, 42-47) were synthesized in this work. All the synthesized compounds were evaluated for their antiplatelet activities. The r

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31

廖英舜. "Design, Synthesis and Biological Evaluation of 5-(1,2,4-Oxadiazol-3-yl)uridine Derivatives." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/10302593033360195001.

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碩士<br>國立臺灣師範大學<br>化學系<br>98<br>TMPKmt (thymidine monophosphate kinase of Mycobacterium tuberculosis) catalyzes the conversion of thymidine to TMP (thymidine monophosphate). TMP is an important component for DNA replication. According to the affinity between TMPKmt for the TMP analogues, we interpreted that there could be a binding pocket in TMPKmt around the 5-substituent on thymidine. Therefore, 5-substituted uridine derivatives could be potential agents possessing antiviral and anticancer activities. Synthesis of 5-(5-substituted-1,2,4-oxadiazole)uridine was accomplished starting from 5-cyan

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Gonçalves, João Miguel de Jesus. "Synthesis of potentially bioactive Diels-Alder 5-HydroxymethylFurfural adducts." Master's thesis, 2017. http://hdl.handle.net/10451/36144.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2017<br>In the past years, we have come to experience some negative effects of long term world reliance on fossil derived production. The effects on the environment are extensive and observable and, on top of this, chaotic oil market prices have been causing great concern. In the current context, pressure to develop new methods of production derived from renewable sources has extended to all areas of big industry. Chemical Industry is no exception. The majority of carbon based starting

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33

Tsai, Ray-Ying, and 蔡睿盈. "Synthesis，Antiplatelet，Antiangiogenesis and Cytotoxicity Activity of 1-Benzyl-3-(5-substituted-2-furyl)-5-methoxy-1H-indazole Derivatives." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/68278761980375752184.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>91<br>Abstract 1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) was first synthesized in our laboratory as a novel antiplatelet agent. Encouraged by the initial results, a series of 5-methoxy derivatives of YC-1 analogues were synthesized and examined for their biological activities. The starting material methyl 5-(3-methoxybenzoyl)-2-furoate (1) was treated with benzylhydrazine to yield a mixture of E- and Z-form isomers 2. The hydrazone was then treated with lead tetraacetate in dichloromethane at low temperature, then boron trifluoride e

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34

Chia-Hao, Wei, and 韋家皓. "The studies of the synthesis of 5-hydroxycalix[4]arene and its acetate derivatives." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/szdknh.

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碩士<br>中國文化大學<br>化學系應用化學碩士班<br>105<br>Calixarenes, which are cyclic oligomers of p-substituted phenols and formaldehyde , are able to include small organic molecules or metal ions within the molecular cavities to form“ host-guest”complexes. These phenomena have been proposed in the applications of micro-analysis, ion separation, and enzyme-mimic studies. The main purpose of this thesis is to study the synthesis of p-hydroxycalix[4]arene and its acetate derivatives. In the basic conditions, p-tert-butylphenol were polymerized with formaldehyde to form a yellowish precursor. Refluxing of this p

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35

Liu, Chin-Yu, and 劉晉育. "Synthesis of hydrophilic derivatives of 5-Methyl-2-(3-methoxyphenyl)-1,8-naphthyridin-4-one." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/03648744475882260917.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>In our previous studies of 2-phenyl-1,8-naphthyridine-4-one (2-PN) derivatives, compounds with a methyl group at the 5- or 6- position, were potent inhibitors of tubulin polymerization and showed remarkable cytoxicity in vitro against leukemia (HL-60), prostate cancer (PC-3), ovarian cancer (OVCAR-3), CNS cancer (SF-295) and melanoma (SF-MEL-5). 2-phenyl-1,8-naphthyridine-4-ones were synthesized according to following steps: condensation of substituted 2-aminopyridines (4,5) with substituted ethyl benzoylacetates (3) in the presence of polyphosphoric aci

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Yang, Chun-Ting, and 楊君鼎. "Synthesis of (5-methyl-2-furyl) imidazo [4,5-b]pyridine Derivatives as Antiplatelet Agents." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/61659545056673902803.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>100<br>In continuing development of novel aniplatelet agents, we had found that 1-benzyl-2-(5-methyl-2-furyl)benzimidazole ( I ) showed good platelet inhibitory activity. Compound I showed good inhibitory effect on the platelet aggregation induced by collagen、arachidonic acid、U46619. Encouraged by this result,the Compound I was selected as a lead compound and a series of 5(or 6)-halo-1-substituted benzyl-2-(5-methyl-2-furyl)imidazo[4,5-b]pyridine (3~40) were synthesized in this work. All the synthesized compounds were evaluated for their antiplatelet activitie

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Flynn, Bernard L. "The synthesis and palladium-catalysed coupling of 5-Trifluoromethanesulfonyluridine derivatives / by Bernard L. Flynn." Thesis, 1992. http://hdl.handle.net/2440/21543.

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38

Tsai, Yun Zhan, and 蔡昀真. "Synthesis and evaluation of 5-Nitrobenzamide derivatives as anti-tumor cells-induced platelet aggregation agents." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/j32zg7.

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Tsai, Wen-wei, and 蔡文偉. "Design and synthesis of 5'-Hydroxyurea adenosine and their derivatives as potential HCV helicase inhibitors." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/01334470741179452707.

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碩士<br>國立臺灣大學<br>藥學研究所<br>88<br>Abstract This thesis is aimed to develop and synthesize adenine containing hydroxyurea derivatives as potential HCV helicase inhibitors. Two series of compounds containing hydroxyurea moiety were proposed and synthesized as potential antiviral agents. We expect that these compounds can target the NTP-dependent helicase and produce efficacy against HCV. The type I compounds are nucleoside derivatives which contain adenosine and hydroxyurea moieties. The type II compounds are non-nucleoside derivatives that connect adenine moiety and hydroxyurea moie

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40

Chang, Chia-Lin, and 張嘉麟. "Synthesis and Biological Activity of Ethyl 5-(2'-Alkoxycarbonyl substituted phenoxy)furan-2-carboxylate Derivatives." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/75686963187553654926.

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博士<br>中國醫藥學院<br>藥物化學研究所<br>90<br>A series of ethyl 5-(2'-alkoxycarbonyl substituted phenoxy)furan-2-carboxylate derivatives has been synthesized and identified. All of these synthetic compounds were evaluated for antiplatelet aggregation, anti-allergic and anti-inflammatory activities. In synthesis, CsF promoted the esterification of salicylic acids to give substituted salicylic acid methyl ester (2-4 and 6-13). Ethyl 5-nitro-2-furoate (14) was synthesized by the nitration reaction from ethyl furoate with fuming nitric acid. Ethyl 5-(2'-alkoxycarbonyl substituted phenoxy)furan-2-car

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Tu, Tzu-Chiang, and 杜自強. "Study of synthesis of 4-carbamoyl-1-(5-carboxypentyl)pyridin-1-ium salts and derivatives." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/41311024910203387926.

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碩士<br>國立高雄師範大學<br>化學系<br>100<br>A series of 4-carbamoyl-1-(5-carboxypentyl)pyridin-1-ium salts with different anions (Br、NO3、BF4、PF6、OTf、BPh4、ZnBr42-、CuBr42-)and deprotonated carboxylate zwitterion have been synthesized and anions (Br、PF6、OTf) have been characterized by single crystal X-ray diffraction. The results demonstrate that the unparallel diamide-substituted pyridinium salts form a dimerized rectangular building block and a 2-D rectangular structure via N-H∙∙∙O and C-H∙∙∙O hydrogen bonding (OTf-), a 2-D sheet structure (Br-, PF6-) via N-H∙∙∙O hydrogen bonding catemers, and a 2-D plate

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Hour, Mann-Jen, and 侯曼貞. "Synthesis, Cytotoxicity and Antiplatelet Activity of 6,7,2',3',4',5'-Substituted 2-phenyl-4-quinazolinone Derivatives." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/66215076548891573814.

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博士<br>中國醫藥學院<br>藥物化學研究所<br>88<br>As part of our continuing search for potential anticancer candidates of 2-phenyl-4-quinazolinones and 2-phenyl-4-quinolones, two series of 6,7,2',3',4',5'-substituted 2-phenyl-4-quinazolinones and 6,2',3',4',5'-substituted 2,3-dihydro-2-phenyl-4-quinazolinones have been synthesized and evaluated for cytotoxicity and inhibition of tubulin polymerization. Through these biological screening, a preliminary structure-activity relationship has been established. On the whole, a good correlation was found between the two activities. Among them, 6-N,N-dimethylamino and

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Yu-Fu, Lin, and 林鈺富. "Synthesis and Cytotoxicity of 5, 6, 2'', 3''-Substituted 2-phenyl-1,8-naphthyridin-4-one Derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/88768364783242521938.

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碩士<br>中國醫藥大學<br>藥物化學研究所<br>92<br>Astract The purpose of this research was to seek for the accurately synthetic method and condition of the PN compounds that our laboratory had developed in the past. This paper was divided into two parts with emphasis. The first part was focused on the way of the heat. The traditional heat was used with the sand bath, and the stable synthetic condition was obtained. In this condition, a series of PN compounds were synthesized. On the other hand, the microwave was used for attempting to enhance the yield. Confirmed after repeated experiment

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Lin, Chao-Jung, and 林昭蓉. "Synthesis of Carbamate and Amine derivatives of(5 or 6)-Methyl-2-(3-methoxyphenyl)-1,8-naphthyridine." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/47037739675343332384.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>5-Methyl-2-(3-methoxyphenyl)-1,8-naphthyridine (6a) and 6-methyl-2-(3-methoxyphenyl)-1,8-naphthyridine (6b) have been synthesized and shown potent cytotoxicity. However, during the undergoing in vivo tests and other preclinical studies, their limited water solubility complicated the issues of IV preparation and oral formulation. To simplify these issues several carbamate and amine derivatives of 6a were synthesized and their cytotoxicity were examined. Strangely, attempted to introduce a bromo group into the benzylic carbon of 6a or 6b by treatment with NBS

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賴玉琪. "Synthesis and biological activities of (2E)-3-[2-(substituted benzyloxy0-4(or 5) methoxyphenyl] acrylaldehyde derivatives." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/01580863496631727352.

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Feng, Liping. "Synthesis and biological evaluation of retinoyl and docosahexaenoyl derivatives of 5-Fluoro-2' -deoxyuridine as anticancer prodrugs /." 2003.

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Sun, Chong-si, and 孫崇喜. "Asymmetric Synthesis of 4- or 5-Oxopipecolic Acid Derivatives via Palladium-Catalyzed Formate Reduction and Enolate Allylation." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/20660256704409751384.

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碩士<br>國立中央大學<br>化學研究所<br>95<br>The method for regioselective palladium-catalyzed formate reduction of allylic benzoate formed by ring closing metathesis was developed. We used 2,2-diphenyl-tetrahydro-2H- pyrane 4 as the model compound, and found an optimized condition of formate reduction by screening several ligands. 4- or 5-Substituted pipecolic acid precursors 28a, 29, 35, 36 and 38, which are biologically active compounds or their precursors, were synthesized by this method. The key steps of these syntheses involve the formation of the skeleton of pipecolic acids with ring closing metathes

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Almeida, Mário Rui Dias. "Synthesis of 5-aryl-imidazo [2,1-b] thiazole compounds possibly RAF kinase inhibitors." Master's thesis, 2014. http://hdl.handle.net/10451/38753.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Malignant melanoma is the most aggressive type of skin cancer because of its high tendency to metastasize. In fact, the mortality rate from malignant melanoma has risen about 2% annually since 1960. Malignant melanoma occupies the 19th place as the most common cancer worldwide. In Portugal, according to the Portuguese League Against Cancer are nearly 700 new cases of melanoma annually and the incidence rate reaches 6-8 cases per 100000 individuals. These data are similar to Sou

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Salahi, Rashad al [Verfasser]. "Synthesis of novel 2-alkoxy(aralkoxy)-4H-[1,2,4]triazolo[1,5-a]quinazolin-5-ones and derivatives / by Rashad Al-salahi." 2009. http://d-nb.info/993198538/34.

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Su, Wei-Nien, and 蘇威年. "Convenient and Efficient“One-pot”Synthesis of N-(1,3-Diphenyl-1H-pyrazole-5-yl)amide Derivatives: Positive allosteric Modulators of mGluR5." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/14099096043064355484.

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碩士<br>中國醫藥大學<br>藥物化學研究所<br>96<br>Glutamate is the major excitatory transmitter in the mammalian central nervous system. Metabotropic glutamate receptors (mGluRs) play an important role in controlling neuronal excitability and synaptic transmission in the central nervous system (CNS) of the mammalian brain. N-(1.3-Diphenylare1-H-pyrazol-5-yl)benzamide derivatives were recently developed as the first centrally active positive allosteric modulator of rat and human metabotropic glutamate receptor mGluR5 subtype. N-(1,3- diphenyl-1H-pyrazol-5-yl)amide derivatives were convenient and efficient synth

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