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Dissertations / Theses on the topic 'Synthesis of nucleoside analogues'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Armstrong, Peter Lloyd. "Synthesis of nucleoside analogues." Thesis, Sheffield Hallam University, 1993. http://shura.shu.ac.uk/19287/.

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A basic introduction to a variety of nucleoside derivatives is described along with a selection of recent syntheses of the said compounds. Initial studies on the synthesis of the key furan based intermediate N-2,5-dihydro-5-(2,2-dimethyl-1,3-dioxolan-4-yl)furanyl trichloroacetamide which when hydrolysed to the free amine would yield a simple route to a variety of nucleoside derivatives. The synthesis was performed via the use of an aza-Claisen rearrangement on 1,4-anhydro-2-deoxy-5,6-O-isopropylidene-D-arabino-hex-1-enitol employing trichloroacetonitrile. This reaction proceeded to the desired

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2

Figueras, Sorinas Antoni. "Stereoselective Synthesis of Cyclobutane Nucleoside Analogues." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/107977.

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Aquesta tesi doctoral s’emmarca dins un projecte dirigit a la síntesi de nous anàlegs de nucleòsids i la seva avaluació com a possibles agents antivírics. Concretament, la major part d’aquest treball es basa en la preparació d’anàlegs ciclobutànics de nucleòsids, utilitzant la reacció de fotocicloaddició [2+2] de 2(5H)-‐furanones quirals a 1,1-‐dietoxietilè com a pas clau de la seqüència sintètica per la construcció de l’anell de ciclobutà. Emprant aquesta metodologia, s’ha aconseguit la síntesi d’una nova família d

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3

O'Connell, Grace Josephine. "The enzymatic synthesis of nucleoside analogues." Thesis, University of Warwick, 1994. http://wrap.warwick.ac.uk/2950/.

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Ribavirin, 1--D-ribofuranosyl-1,2,4-triazole-3-carboxamide, is a broad spectrum antiviral agent active against both DNA and RNA viruses. A range of 1,2,3-triazole, 1,2,4-triazole and benzotriazole analogues of ribavirin was synthesised using a crude extract of N-deoxyribosyltransferases from Lactobacillus leichmannii in the chemoenzymatic synthesis of nucleoside analogues with potential antiviral activity. N-Deoxyribosyltransferase catalyses the transfer of the 2-deoxyribose sugar between purine and pyrimidine bases. Of thirty two bases synthesised, twelve were found to act as acceptors in the

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4

Pal, Ayan. "Synthesis Of Nucleoside Analogues: Glycosylation, Rigid Nucleosides And Janus Wedge Derivatives." Thesis, Boston College, 2012. http://hdl.handle.net/2345/2750.

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Thesis advisor: Larry W. McLaughlin<br>Thesis advisor: Mary F. Roberts<br>Nucleic Acids are unique biopolymers capable of encoding and transferring genetic information from one generation to the next for every form of life. This fascinating property has made them the topic of intense research from a variety of aspects. Some researchers try to understand how life might have started. Some try to elucidate how the whole process works. Some try to use the properties of nucleic acids as a tool for various purposes. The continuous effort over more than a century explored a lot about the structures a

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5

Parry, David Mark. "Synthesis of some fluorinated carbocyclic nucleoside analogues." Thesis, University of Exeter, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305731.

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6

Cormier, James. "The synthesis of nucleoside and silyl nucleotide analogues /." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75458.

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A route to the synthesis of arabino and xylonucleosides is described. This route takes advantage of highly selective ribonucleoside hydroxyl protection procedures which have recently been developed. The route is straightforward and broadly applicable. It may be applied to both purine and pyrimidine nucleosides. Synthesis, deprotection, and characterisation of the target compounds are described. The work is compared to that of others in the field.<br>A novel class of oligonucleotide analogues is described. In this group, the phosphorus atom of the internucleotide link is replaced by silicon. Th

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7

Jurado, Moreno Sergio. "Stereoselective Synthesis of Conformationally Restricted Cyclohexanyl Nucleoside Analogues." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670584.

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En les darreres dècades, l’ús d’anàlegs de nucleòsids (ANs) ha despertat un gran interès de recerca per a la teràpia antiviral i anticancerigen. La conformació i el plegament de la unitat de sucre dels nucleòsids tenen un paper crític en la modulació de la seva activitat biològica. En aquest context, s’han dissenyat i sintetitzat nous anàlegs de carbanucleòsids (ACNs) restringits conformacionalment per imitar el comportament conformacional de l’anell de furanosa natural. Els nucleòsids ciclohexenílics són un tipus prometedor de compostos antivirals, en què la substitució de l’àtom d’oxigen de

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8

Jasamai, Malina. "The synthesis of novel 6-azapyrimidine nucleoside analogues." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/55438/.

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A series of novel acyclic oxonucleoside, 2',3'-dideoxy-4'-thio- and 4'-thio-L-nucleoside analogues have been prepared. An attempt to synthesise the acyclic thio moiety was unsuccessful. The novel analogues synthesised will be evaluated biologically at the Rega Institute in Leuven, Belgium as potential antiviral agents using a wide screen of viral assays including Human Immunodeficiency Virus type 1 and 2 (HIV 1 and HIV 2), Herpes simplex Virus type 1 and 2 (HSV 1 and HSV 2) and Varicella Zoster Virus (VZV).

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9

Clayton, Russell. "The synthesis of nucleoside analogues from nitroimidazole precursors." Thesis, Keele University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341240.

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An introduction to nucleoside analogues containing heterocyclic sugar mimics and their synthesis is presented. This includes various ring sizes and different heteroatom combinations. concentrated on work between 1995-2000. The synthesis of novel nucleoside analogues from nitroimidazole precursors has been investigated. The regioisorners I-vinyl-4-nitroimidazole and I-vinyl-S-nitroimidazole have been synthesised from the readily available 4/S-nitroimidazole. Also synthesised from 4/S-nitroimidazoIe IS 3-vinyl-imidazo[ 4' ,S' :S,6]pyrido[2,3- d]pyrimidin-8-one, the pyridine stretched analogue of

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10

Gardner, S. J. "The synthesis of novel nucleoside analogues from nitroimidazoles." Thesis, Keele University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388875.

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11

Gdarah, Khaled M. "The synthesis of some nucleoside analogues as antitumour agents." Thesis, Brunel University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332000.

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12

Garcia, Margarita. "Synthesis and template-directed polymerisation studies of nucleoside analogues." Thesis, University of Warwick, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397749.

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13

Chan, Heng Ming. "Synthesis of pyrimidine C-nucleoside analogues and triphosphate derivatives." Thesis, Boston College, 2008. http://hdl.handle.net/2345/36.

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Five pyrimidine C-nucleosides were prepared via Heck-type coupling reactions. These derivatives are designed to mimic dC and dU (or T). The minor groove O2 carbonyl in each derivative is replaced by a hydrogen, a fluorine, or a methyl group. The hydrogen-substituted dC analogue was converted into a 2’,3’-dideoxynucleoside, which was converted into a 5’-triphosphate derivative. The other two dC analogues were transformed into 5’-triphosphate derivatives immediately after Heck coupling reactions. These analogues will allow an examination of the nature and role of minor groove interactions betwee

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14

Cong, Mei. "Design, synthesis and characterization of novel triazole nucleoside analogues." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4018.

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Les analogues de nucléosides sont d'une importance considérable dans la recherche de nouveaux candidats médicaments antiviraux et anticancéreux. La ribavirine est en effet le premier nucléoside triazole antiviral synthétique. Elle est toujours activement utilisée en milieu hospitalier pour le traitement de l'hépatite C et celui des pandémies virales émergentes. Récemment, le besoin de nouveaux agents thérapeutiques efficaces dotés de nouveaux mécanismes d'action a donc créé un regain d'intérêt dans la création de nouvelles entités structurelles de nucléosides triazoles. Au cours de mon doctora

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15

Rayala, Ramanjaneyulu. "Design and Synthesis of Novel Nucleoside Analogues: Oxidative and Reductive Approaches toward Synthesis of 2'-Fluoro Pyrimidine Nucleosides." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2172.

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Fluorinated nucleosides, especially the analogues with fluorine atom(s) in the ribose ring, have been known to exert potent biological activities. The first part of this dissertation was aimed at developing oxidative desulfurization-fluorination and reductive desulfonylation-fluorination methodologies toward the synthesis of 2'-mono and/or 2',2'-difluoro pyrimidine nucleosides from the corresponding 2'-arylthiopyrimidine precursors. Novel oxidative desulfurization-difluorination methodology was developed for the synthesis of α,α-difluorinted esters from the corresponding α-arylthio esters, whe

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16

Visintin, Cristina. "Studies in the synthesis of acyclic nucleoside analogues and oligonucleotides." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313052.

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17

Powers, Victoria Ellen Clare. "Synthesis and studies of nucleoside analogues in triplex forming oligonucleotides." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415236.

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18

Ballatore, Carlo. "Synthesis and evaluation of novel phosphoramidate prodrugs of nucleoside analogues." Thesis, Cardiff University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729322.

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19

Coe, Diane Mary. "Synthesis of carbocyclic nucleoside and nucleotide analogues as potential antiviral agents." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294036.

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20

Hutchinson, Edward John. "The synthesis of novel nucleoside analogues as potential plant growth inhibitors." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385732.

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21

Ismail, Media K. "Synthesis and anticancer activity of metallocene-containing nucleoside and DNA analogues." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8644/.

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After the discovery of cisplatin, the development of metal-containing anticancer drugs has been the subject of much research, with the aim of achieving high activities with minimal side effects. Metallocene derivatives are now common place within this field. Building on work previously published work by the Tucker group on ferrocene-containing nucleoside analogues, further research has now been undertaken to explore structure activity relationships. Firstly, the study has involved changing the substitution pattern through the synthesis of a series of regioisomeric derivatives, while maintainin

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22

Cima, Cecilia. "Computer-aided design and synthesis of novel anti-DENV nucleoside analogues." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/98340/.

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Dengue virus (DENV) is one of the most important human pathogens among the genus flavivirus, with 3.9 billion people at risk of infection through mosquitoes, such as the widely spread ‘Asian tiger’ mosquitoes, and the four serotypes of DENV are endemic in over 100 countries in tropical and subtropical regions. Clinical manifestations of infection with DENV range from flu-like symptoms to the life-threatening dengue haemorrhagic fever. The dramatic increase in the incidence of the DENV infection, the rapid spread of DENV to new areas and the recent re-emergence of another member of the genus fl

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23

Domínguez, Pérez Beatriz. "Rational design and synthesis of new nucleoside analogues bearing a cyclohexane core." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/300747.

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L’ús d’anàlegs de nucleòsids en teràpia antivírica s’ha convertit en una opció important durant les tres últimes dècades. En els últims anys, l’atenció s’ha centrat en els carbanucleòsids, que són més resistents als processos hidrolítics i tenen una millor absorció i penetració a través de la membrana cel·lular com a resultat de la seva major lipofília. Els anàlegs de nucleòsids amb estructura ciclohexènica són una classe prometedora de compostos antiviral, en què la substitució de l’àtom d’oxigen de l’anell de furanosa per un doble enllaç indueix una flexibilitat anul·lar similar a la dels nu

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24

Kukwikila, M. N. "Synthesis of nucleoside analogues and peptides for nanoore analysis and controlled bioactivity." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1402763/.

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This research describes the synthesis of nucleoside analogues and peptides, and their application to nanopore technology and cell biology. Nanopore technology is a technique in which analytes are detected by disturbances in ionic current caused as they traverse a pore, at a fixed applied potential. Here potential applications of the technology are explored. A nanopore-based method to detect enzymatic activity was investigated. The technique involved the detection of peptide fragments proteolytically released from a solid-support. The released fragments gave rise to distinct electrical signals

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25

Gooding, Heather. "The synthesis of carbocyclic and bicyclic nucleoside analogues as potential antiviral agents." Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357140.

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26

Stefan, Carmen Mirela. "Synthesis of C-nucleoside analogues for mechanistic study of uracil DNA glycosylase." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0002412.

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27

Lou, Chenguang. "Synthesis and properties of triplex-forming oligonucleotides containing 2'-modified nucleoside analogues." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/202493/.

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Triplex-forming oligonucleotides (TFOs) bind to the major groove of the DNA duplex via the Hoogsteen interactions to generate triple helices. Potential applications of triplex technology are in regulation of gene expression, site-directed gene-knockout, mutation correction and as tools in molecular biotechnology. The presence of 2’-modified nucleosides in therapeutic oligonucleotides inhibits enzymatic degradation in vivo. Therefore such sugar modifications have the potential to improve the biological activity of TFOs. We have synthesized the phosphoramidite monomers of six 2’-modified nucleos

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28

Grand, Simon Christopher. "The synthesis of carbocyclic nucleoside analogues using rhodium carbenoid C-H insertion reactions." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367403.

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29

Holmes, S. C. "The synthesis of modified nucleosides and their incorporation into the hairpin ribozyme catalytic motif for future structural and kinetic analyses." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324443.

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30

Hicks, Nicola. "The enzymatic and chemical synthesis of nucleoside analogues using N-deoxyribosyltransferase from Lactobacillus leichmannii." Thesis, University of Warwick, 1992. http://wrap.warwick.ac.uk/2987/.

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N-deoxyribosyltransferase catalyses the transfer of 2-deoxy-I 2.3, -dideoxyand 2,5-dideoxyribose sugars between purine and pyrimidine bases. In this work, a crude extract of N-deoxyribosyltransferase from Lactobacillus leichmannii was used in the chemoenzymatic synthesis of nucleoside analogues with potential antiviral activity, in particular, 9-P-D-2', 3'- dideoxyribofuranosyl 2-aminopurine which had anti-HIV activity. The immobilisation of a crude extract of N-deoxyribosyltransferase on a variety of support matrices is described. The most successful matrices were octyl Sepharose and Poly(acr

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31

Predescu, Mihaela Narcisa. "Synthesis of nucleoside analogues and fluorescent labels for DNA sequencing and other applications in biotechnology." Thesis, Texas A&M University, 2005. http://hdl.handle.net/1969.1/2532.

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Two pyrrolo[2,3-d]pyrimidines and a nucleoside analogue have been prepared. The nucleobases were obtained by spontaneous cyclisation of 4-aminopyrimidyl-acetaldehydes as an acetal. The adenosine analogue has been made by glycosylation of a suitable sugar derivative with the corresponding heterocyclic base. This nucleoside can be converted into fluorescently-labeled chain-terminating substrates for DNA polymerase after subsequent triphosphorylation and coupling to through-bond energy transfer systems. Fluorescein-based donor components to be incorporated into through-bond energy transfer system

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32

Crawford, Julia Ann. "A study of synthetic routes to pyridine-stretched nucleoside analogues." Thesis, Keele University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414756.

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An introduction to the use of oligonucleotides as antigene or antisense therapeutic agents is presented. This includes an analysis of the major areas of structural change implemented to improve the stability, specificity, nuclease resistance and cellular delivery of oligonucleotides. The synthetic aspect of the project concerns the preparation of two novel 'pyridinestretched' heterocyclic bases principally designed to improve base stacking. The first of these, 8-amino-3 -(2-deoxy-J3-D-ribofuranosyl)-imidazo [4' ,5': 5 ,6]pyrido[2,3-d]pyrimidine, is a stretched adenosine analogue which may be s

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33

Alabdullah, Bader Saleh. "Synthesis of Novel Nucleoside Analogs Targeting HCV." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1524827142181671.

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34

Flores, Pons Ramon. "Photochemical preparation of highly substituted cyclobutane and cyclobutene compounds. Stereoselective synthesis of cyclobutane nucleoside analogues." Doctoral thesis, Universitat Autònoma de Barcelona, 2008. http://hdl.handle.net/10803/3290.

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El treball que es recull en la present tesi ha consistit, en primer lloc, en l'estudi de la reactivitat fotoquímica d'una sèrie de lactones i lactames quirals α,β-insaturades en front d'altres substrats insaturats com ara etilè, acetilè o dietil acetal de cetena així com alquins mono i disubstituits. La finalitat d'aquest estudi era construir derivats ciclobutànics i ciclobutènics enantiomèricament purs altament funcionalitzats mitjançant reaccions de fotocicloaddició [2+2]. Per aquest motiu s'han establert les millors condicions per a dur a terme les reaccions fotoquímiques (tempera

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35

Spencer, Keith. "Parallel synthesis of C-nucleosides." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325958.

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36

Varley, David Robert. "The synthesis of novel analogues of adenosine." Thesis, University of Exeter, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307291.

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37

Sacasa, Pablo R. Jr. "Developing of Germyldesulonylation and Thiodesulfonylation Reactions for the Synthesis of Novel Nucleoside Analogues. Efficient Synthesis of Novel (α-Fluoro)vinyl Sulfides". FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/265.

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S-adenosyl-L-homocysteine (AdoHcy) hydrolase effects hydrolytic cleavage of AdoHcy to produce both adenosine and L-homocysteine and is a feedback inhibitor of S-adenosyl-L-methionine (SAM). Nucleoside analogues bearing an alkenyl or fluoroalkenyl chain between sulfur and C5′ utilizing Negishi coupling reactions were synthesized. Palladium-catalyzed cross-coupling between the 5′-deoxy-5′-(iodomethylene) nucleosides and alkylzinc bromides gives analogues with the alkenyl unit. Palladium-catalyzed selective monoalkylation of 5′-(bromofluoromethylene)-5′-deoxy-adenosine with alkylzinc bromide affo

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38

Thorpe, Andrew John. "Synthetic approaches to novel adenosine analogues and the synthesis of potential antiviral agents." Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357951.

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39

Usman, Nassim. "Nucleoside phosphoramidites in the automated, solid phase synthesis of oligoribonucleotides and their analogues : the chemical synthesis of an E. Coli N-Formyl-Methionine tRNA." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75344.

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The use of ribonucleoside phosphoramidites protected at the 2$ sp prime$-hydroxyl with alkylsilyl ethers was developed for the solid phase synthesis of oligoribonucleotides. A series of pentadecameric oligomers of various base composition was synthesized using this methodology and a complete protocol for the deprotection of synthetic oligoribonucleotides was developed. The use of $ beta$-cyanoethyl phosphate protection was compared to that of methyl protection in the synthesis of pentadeca-uridylic acid sequences and no significant difference between the use of the two protecting groups was fo

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40

Kahane, Alexandra L. "Restriction of DNA conformation by spirocyclic annulation at C4': synthesis of the nucleoside building blocks." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1072903762.

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41

Silvestre, Katherine J. "Spectroscopic analysis and synthesis of nucleoside analogs for lethal mutagenesis." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/100159.

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Thesis: S.B. in Chemistry and Biology, Massachusetts Institute of Technology, Department of Chemistry, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 34-35).<br>The high mutation rate of HIV makes treatment of HIV/AIDS difficult, as the virus can develop resistance to existing therapeutics. A novel antiviral nucleoside analog, 5-Aza-5,6-dihydro-2'- deoxycytidine (KP1212), employs the mechanism of lethal mutagenesis to avoid the problem of drug resistance and use the virus's high mutation rate against it. KP1212 is incorporated into DNA by HIV rever

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42

Zhou, Xinrui [Verfasser], Peter [Akademischer Betreuer] Neubauer, Igor A. [Akademischer Betreuer] Mikhailopulo, Roland [Akademischer Betreuer] Wohlgemuth, and Vera [Akademischer Betreuer] Meyer. "Thermostable nucleoside phosphorylases as biocatalysts for the synthesis of purine nucleoside analogues / Xinrui Zhou. Gutachter: Peter Neubauer ; Igor A. Mikhailopulo ; Roland Wohlgemuth ; Vera Meyer. Betreuer: Peter Neubauer ; Igor A. Mikhailopulo." Berlin : Technische Universität Berlin, 2014. http://d-nb.info/1067385991/34.

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43

Hysell, Michelle Hysell Michelle. "I, triazine nucleoside analogues : synthesis and study of their physical properties ; II, C1 domain contribution to protein kinase C membrane recruitment /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3153684.

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44

Dayde, Bénédicte. "Développement de phosphasucres inédits pour la synthèse d’analogues de nucléosides à visée antivirale." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2010. http://www.theses.fr/2010ENCM0002.

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De par leur grande diversité chimique et leur implication dans de nombreux mécanismes biologiques, les molécules phosphorées font l'objet de nombreuses recherches scientifiques. Depuis près de 30 ans, plusieurs composés phosphorés ont été développés et utilisés pour leurs propriétés médicinales ou phytosanitaires. Les dérivés de type phosphinates ou phosphonates se sont révélés être des composés de choix, grâce à leur grande stabilité chimique et enzymatique. Par ailleurs, les sucres et leurs analogues ont largement démontré leur potentiel biologique en raison de leur implication dans de nombr

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45

Choi, Ka Wai. "Analogues of Natural Product-like Scaffolds: Synthesis of Spiroacetal Derivatives." Thesis, University of Auckland, 2008. http://hdl.handle.net/2292/2628.

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Diversity-oriented synthesis (DOS) involves the synthesis of several synthetic targets by transforming a collection of structurally simple and similar starting materials into a collection of structurally more complex and diverse products. This thesis describes the elaboration of a 6,6-spiroacetal scaffold to incorporate biologically useful moieties, in particular nucleobases, triazoles and amino acids, thus generating a collection of novel hybrid structures. The research reported, herein, focused on the synthesis of spiroacetal-nucleosides, triazoles and amino acids bearing a C8′-hydroxymethyl

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46

Tench, Allen James. "The synthesis of novel anti viral nucleosides and novel glutamic acid analogues." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394416.

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47

Kessler, Ulrich. "Random synthesis and biological characterization of nucleoside analogs - new perspectives for drug discovery /." [S.l.] : [s.n.], 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13592.

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48

Yueh, Han. "Synthesis and Study of Rigidified Nucleosides Analogues for Probing the Importance of the Deoxyribose DNA Backbone." Thesis, Boston College, 2012. http://hdl.handle.net/2345/2895.

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Thesis advisor: Larry W. McLaughlin<br>Thesis advisor: Mary F. Roberts<br>Nucleic acids are the only biopolymers capable of encoding and transferring information, this property has placed them at the fundamental core of all living organisms, and made them a topic of intense research for over a century. The former studies in our laboratory on simplified nucleic acid backbones provided insight into how we might rationally alter nucleic acid structure into one that possesses properties not observed in natural DNA and RNA. Here the work began as an investigation into rigidified nucleic acid system

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Rosa, Alvarenga Flavia Cristina. "Synthèse de nouveaux analogues de nucléosides potentiellement antiviraux." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV068/document.

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Les analogues synthétiques des nucléosides naturels constituant des acides nucléiques occupent une place importante dans le domaine du médicament comme principes actifs antiviraux ou anticancéreux. Ces nucléosides agissent comme « prodrogues » en perturbant la biosynthèse des acides nucléiques viraux ou des cellules cancéreuses après phosphorylation. Dans la recherche de nouveaux médicaments antiviraux, nous avons cherché à synthétiser de nouveaux analogues des nucléosides naturels, les 2-désoxy-adénosine et -guanosine, et de l’aciclovir et de ses dérivés (vanciclovir, ganciclovir…) qui sont t

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Kincaid, Karen Kristin. "Studies of nucleotide analogues: DNA polymerase fidelity and the solid-phase synthesis of nucleosides and nucleotides." Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3219202.

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