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1

Pharmaceutical water: System design, operation, and validation. Interpharm Press, 1999.

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2

Pharmaceutical water: System design, operation, and validation. Informa Healthcare, 2011.

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3

Smilowitz, Gary J. Final design, integration and validation of the PANSAT antenna system. Naval Postgraduate School, 1997.

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4

Kambhampati, Subbarao. A validation structure based theory of plan modification and reuse. Dept. of Computer Science, Stanford University, 1990.

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5

Santoro, Robert J. Detailed experimental data for CFD code validation. Propulsion Engineering Research Center, College of Engineering, Pennsylvania State University, 1998.

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6

Leszak, M. Petri-Netz-Methoden und -Werkzeuge: Hilfsmittel zur Entwurfsspezifikation und -validation von Rechensystemen. Springer, 1989.

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7

Saito, Jim. Digital-flight-control-system software written in automated-engineering-design language: A user's guide of verification and validation tools. National Aeronautics and Space Administration, Ames Research Center, 1988.

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8

Saito, Jim. Digital-flight-control-system software written in automated-engineering-design language: A user's guide of verification and validation tools. National Aeronautics and Space Administration, Ames Research Center, 1988.

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9

Embedded systems and software validation. Elsevier Morgan Kaufmann, 2009.

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10

Bandy, Howard B. Quantitative trading systems: Practical methods for design, testing, and validation. Blue Owl Press, 2007.

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11

Debbabi, Mourad. Verification and validation in systems engineering: Assessing UML/SysML design models. Springer, 2010.

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12

DeBor, J. Man-machine interface issues in nuclear power plants: Report on a workshop held on January 10-12, 1989. Division of Systems Research, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission, 1989.

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13

DeBor, J. Man-machine interface issues in nuclear power plants: Report on a workshop held on January 10-12, 1989. Division of Systems Research, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission, 1989.

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14

Margaria-Steffen, Tiziana. Leveraging Applications of Formal Methods, Verification, and Validation: 4th International Symposium on Leveraging Applications, ISoLA 2010, Heraklion, Crete, Greece, October 18-21, 2010, Proceedings, Part I. Springer Berlin Heidelberg, 2010.

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15

Margaria-Steffen, Tiziana. Leveraging Applications of Formal Methods, Verification, and Validation: 4th International Symposium on Leveraging Applications, ISoLA 2010, Heraklion, Crete, Greece, October 18-21, 2010, Proceedings, Part II. Springer Berlin Heidelberg, 2010.

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16

Bernhard, Steffen, and SpringerLink (Online service), eds. Leveraging Applications of Formal Methods, Verification and Validation. Technologies for Mastering Change: 5th International Symposium, ISoLA 2012, Heraklion, Crete, Greece, October 15-18, 2012, Proceedings, Part I. Springer Berlin Heidelberg, 2012.

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17

Bernhard, Steffen, and SpringerLink (Online service), eds. Leveraging Applications of Formal Methods, Verification and Validation. Applications and Case Studies: 5th International Symposium, ISoLA 2012, Heraklion, Crete, Greece, October 15-18, 2012, Proceedings, Part II. Springer Berlin Heidelberg, 2012.

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18

Collentro, William V. Pharmaceutical Water: System Design, Operation, and Validation. Informa Healthcare, 1998.

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19

John, Nowakowski, and Langley Research Center, eds. Flight guidance system validation using SPIN. National Aeronautics and Space Administration, Langley Research Center, 1998.

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20

Collentro, William V. Pharmaceutical Water: System Design Operation, and Validation, Second Edition. 2nd ed. Informa Healthcare, 2007.

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21

Integrated system validation: Methodology and review criteria. Division of Reactor Controls and Human Factors, Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, 1997.

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22

Reorda, Matteo Sonza, Massimo Violante, and Zebo Peng. System-level Test and Validation of Hardware/Software Systems. Springer, 2010.

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23

Final Design, Integration and Validation of the Pansat Antenna System. Storming Media, 1997.

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24

Colloquium on model validation for control system design and simulation. Institute of Electrical Engineers, 1989.

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25

System identification methods for aircraft flight control development and validation. National Aeronautics and Space Administration, Ames Research Center, 1995.

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26

Ingólfsdóttir, Anna, Kim Guldstrand Larsen, Jiri Srba, and Luca Aceto. Reactive Systems: Modelling, Specification and Verification. Cambridge University Press, 2007.

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27

Luca, Aceto, ed. Reactive systems: Modelling, specification and verification. Cambridge University Press, 2007.

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28

(Editor), Matteo Sonza Reorda, Zebo Peng (Editor), and Massimo Violante (Editor), eds. System-level Test and Validation of Hardware/Software Systems (Springer Series in Advanced Microelectronics). Springer, 2005.

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29

H, Daugherty Robert, Martinson Veloria J, and Langley Research Center, eds. Modeling and validation of a Navy A6-Intruder actively controlled landing gear system. National Aeronautics and Space Administration, Langley Research Center, 1999.

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30

H, Daugherty Robert, Martinson Veloria J, and Langley Research Center, eds. Modeling and validation of a Navy A6-Intruder actively controlled landing gear system. National Aeronautics and Space Administration, Langley Research Center, 1999.

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31

Quality system supplement to ISO9001 relating to finite element analysis in the design and validation of engineering products. NAFEMS, 1989.

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32

Center, Ames Research, ed. Digital-flight-control-system software written in automated-engineering-design language: A user's guide of verification and validation tools. National Aeronautics and Space Administration, Ames Research Center, 1988.

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33

Center, Ames Research, ed. Digital-flight-control-system software written in automated-engineering-design language: A user's guide of verification and validation tools. National Aeronautics and Space Administration, Ames Research Center, 1988.

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34

National Agency for Finite Element Methods and Standards., ed. Quality system supplement to ISO 9001 relating to finite element analysis in the design and validation of engineering products. NAFEMS, 1993.

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35

Center, Langley Research, ed. Design for validation: An approach to systems validation. National Aeronautics and Space Administration, Langley Research Center, 1989.

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36

Holland, Timothy A. Facility design validation of the Information Systems laboratory. 1987.

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37

Catanzaro, Michael P., and Rachel J. Kwon. Hinchey Classification of Acute Diverticulitis. Edited by Rachel J. Kwon. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199384075.003.0048.

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This chapter provides a summary of a landmark historical study in surgery: the Hinchey classification of acute diverticulitis. It describes the history of the disease, gives a summary of the study including study design and results, and relates the study to a modern-day principle of evidence-based medicine: validation of scoring systems. Hinchey’s classification of diverticulitis has become the most widespread system and while the Hinchey score may currently have less clinical relevance as it did in his time, its publication and eventual adoption marked a practice-changing paradigm shift in the way diverticulitis is viewed and managed today.
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38

Vyas, J. Jaidev, Balamurugan Gopalsamy, and Harshavardhan Joshi. Electro-Hydraulic Actuation Systems: Design, Testing, Identification and Validation. Springer, 2018.

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39

Unger, Herwig, and Wolfgang A. Halang, eds. Autonomous Systems 2016. VDI Verlag, 2016. http://dx.doi.org/10.51202/9783186848109.

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To meet the expectations raised by the terms Industrie 4.0, Industrial Internet and Internet of Things, real innovations are necessary, which can be brought about by information processing systems working autonomously. Owing to their growing complexity and their embedding in complex environments, their design becomes increasingly critical. Thus, the topics addressed in this book span from verification and validation of safety-related control software and suitable hardware designed for verifiability to be deployed in embedded systems over approaches to suppress electromagnetic interferences to strategies for network routing based on centrality measures and continuous re-authentication in peer-to-peer networks. Methods of neural and evolutionary computing are employed to aid diagnosing retinopathy of prematurity, to invert matrices and to solve non-deterministic polynomial-time hard problems. In natural language processing, interface problems between humans and machines are solved with g...
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40

Reid, Chris. The Functional Design Specification: Computer Systems Validation Life Cycle Activities. Sue Horwood Publishing Ltd, 2000.

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41

Bandy, Dr Howard B. Quantitative Trading Systems: Practical Methods for Design, Testing, and Validation. Blue Owl Press, 2011.

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42

Strand, Vibeke, Jeremy Sokolove, and Alvina D. Chu. Design of clinical trials in rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0030.

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Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, 'first-in-human' to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the past 15 years, significant progress has been made in the design of RCTs in rheumatoid arthritis (RA). Similarly, development and validation of composite outcome measures in psoriatic arthritis, ankylosing spondylitis, gout, and osteoarthritis have furthered trial design and treatment approvals. RCTs in systemic lupus erythematosus and other multisystem, heterogeneous diseases pose more challenges. Trial design will continue to evolve as promising therapies are introduced into the clinic.
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43

Strand, Vibeke, Jeremy Sokolove, and Alvina D. Chu. Design of clinical trials in rheumatology. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0030_update_001.

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Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, ’first-in-human’ to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the past 15 years, significant progress has been made in the design of RCTs in rheumatoid arthritis (RA). Similarly, development and validation of composite outcome measures in psoriatic arthritis, ankylosing spondylitis, gout, and osteoarthritis have furthered trial design and treatment approvals. RCTs in systemic lupus erythematosus and other multisystem, heterogeneous diseases pose more challenges. Trial design will continue to evolve as promising therapies are introduced into the clinic.
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44

Strand, Vibeke, Jeremy Sokolove, and Alvina D. Chu. Design of clinical trials in rheumatology. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199642489.003.0030_update_002.

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Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, ’first-in-human’ to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the past 15 years, significant progress has been made in the design of RCTs in rheumatoid arthritis (RA). Similarly, development and validation of composite outcome measures in psoriatic arthritis, ankylosing spondylitis, gout, and osteoarthritis have furthered trial design and treatment approvals. RCTs in systemic lupus erythematosus and other multisystem, heterogeneous diseases pose more challenges. Trial design will continue to evolve as promising therapies are introduced into the clinic.
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45

Huber, Ludwig. Validation of Computerized Analytical and Networked Systems. Informa Healthcare, 2001.

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46

Debbabi, Mourad, Fawzi Hassaïne, Yosr Jarraya, Andrei Soeanu, and Luay Alawneh. Verification and Validation in Systems Engineering: Assessing UML/SysML Design Models. Springer, 2010.

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47

Debbabi, Mourad, Fawzi Hassaïne, and Yosr Jarraya. Verification and Validation in Systems Engineering: Assessing UML/SysML Design Models. Springer, 2011.

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48

Debbabi, Mourad, Fawzi Hassaïne, Yosr Jarraya, Andrei Soeanu, and Luay Alawneh. Verification and Validation in Systems Engineering: Assessing UML/SysML Design Models. Springer, 2014.

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49

W, Metcalf Brian, and Dillon Susan 1952-, eds. Target validation in drug discovery. Academic Press, 2006.

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50

(Editor), Brian W. Metcalf, and Susan Dillon (Editor), eds. Target Validation in Drug Discovery. Academic Press, 2006.

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