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Dissertations / Theses on the topic 'Systemic autoimmune diseases'

Author: Grafiati

Published: 31 May 2025

Last updated: 31 July 2025

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1

Leeuw, Karina de. "Premature atherosclerosis in systemic autoimmune diseases." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.

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2

Lövgren, Tanja. "Endogenous type I interferon inducers in systemic autoimmune diseases /." Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7181.

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3

Lövgren, Tanja. "Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7181.

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<p>Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. The IFN-α is a type I IFN, a family of cytokines counteracting especially viral infections, by acting directly on infected cells, and via many immunomodulatory effects. The latter may also contri

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4

Dumoitier, Nicolas. "Analysis of B lymphocytes in systemic autoimmune vascular diseases." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC304.

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Différents mécanismes de tolérance centraux et périphériques permettent la sélection négative des lymphocytes B auto-réactifs tout en préservant la sélection positive et la différenciation en plasmocytes producteurs d’anticorps de haute affinité. Ces mécanismes de tolérance sont altérés dans les pathologies auto-immunes et ces altérations conduisent à la production d’auto-anticorps. Ainsi, un ciblage thérapeutique des lymphocytes B autoréactifs, notamment avec les anticorps monoclonaux anti-CD20, donne des résultats prometteurs dans différentes pathologies auto-immunes. Si ces traitements ont

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5

Imgenberg-Kreuz, Juliana. "Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-310388.

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Autoimmune diseases are clinical manifestations of a loss-of-tolerance of the immune system against the body’s own substances and healthy tissues. Primary Sjögren’s syndrome (pSS) and systemic lupus erythematosus (SLE) are two chronic inflammatory autoimmune diseases characterized by autoantibody production and an activated type I interferon system. Although the precise mechanisms leading to autoimmune processes are not well defined, recent studies suggest that aberrant DNA methylation and gene expression patterns may play a central role in the pathogenesis of these disorders. The aim of this

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6

Atta, Mustafa S. "Investigation of the humoral and cellular features of autoimmune diseases." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281586.

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7

Wang, Chuan. "DNA Sequence Variants in Human Autoimmune Diseases." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179189.

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Human autoimmune diseases are hallmarked by inappropriate loss-of-tolerance and self-attacking response of the immune system. Studies included in this thesis are focusing on the implication and functional impact of genetic factors in three autoimmune diseases rheumatoid arthritis (RA), asthma, and systemic lupus erythematosus (SLE). Using genetic association studies, we found in study I and II that sequence variants of the interferon regulatory factor 5 (IRF5) gene were associated with RA and asthma, and the associations were more pronounced in certain disease subtypes. Distinct association pa

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8

McCormick, Natalie. "The health resource utilization and economic burden of systemic autoimmune rheumatic diseases." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42149.

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Background: SARDs (Systemic Autoimmune Rheumatic Diseases) are a group of rare, chronic conditions (systemic vasculitis, systemic lupus erythematosus, scleroderma, Sjogren's disease, and poly/dermatomyositis) associated with high health resource consumption. However, estimates of their healthcare burden are sparse, with most determined at tertiary centres over short periods. Studying them separately has also limited research progress. Here we grouped the SARDs, for the first time ever, to quantify their collective, longitudinal (twelve-year) burden at the population-level. Methods: A popula

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9

Duffy, Emeir. "An investigation of the influence of dietary supplementation of n-3 fish oil and/or copper on systemic lupus erythematosus." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273795.

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10

Esfandiari, Ehsanollah. "Role of Th1 and Th2 cytokines in the pathogenesis of systemic autoimmune diseases." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366255.

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11

Prokunina, Ludmila. "Strategies for Identification of Susceptibility Genes in Complex Autoimmune Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4138.

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12

BANKS, THERESA ANNE. "IDENTIFICATION AND SEQUENCE OF THE IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION GENE INVOLVED IN CODING FOR AN ANTI-DNA AUTOANTIBODY." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183939.

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The major pathologic feature of the human autoimmune disease Systemic Lupus Erythematosus (SLE) and its murine counterpart, murine lupus, is the production of autoantibodies to nucleic acid antigens. In this study, a panel of six murine monoclonal anti-DNA autoantibodies was characterized at both the cellular and molecular levels in order to determine their possible role in the etiology of autoimmune disease. At the cellular level the autoantibodies were found to be highly cross-reactive, binding to three different antigenic forms of DNA as well as to the cell surface of various lymphoid cell

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13

Hassan, Adla Bakri. "Mixed connective tissue disease, myositis and systemic lupus erythematosus : immunological and genetic studies in three related rheumatic autoimmune diseases /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-388-0.

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14

Singh, Akriti. "Investigating the role of TLR7 in the activation of autoreactive B cells in systemic lupus erythematosus /." Connect to online version, 2008. http://ada.mtholyoke.edu/setr/webscr/pdfs/www/2008/266.pdf.

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15

Ceribelli, A. "PROTEIN AND RNA IMMUNOPRECIPITATION FOR THE IDENTIFICATION OF SPECIFIC SERUM AUTOANTIBODIES IN SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASES." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/365538.

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Serum autoantibodies play a key role in systemic autoimmune rheumatic diseases for diagnostic, classification and prognostic purposes. Research of new autoantibodies has been very active in the last decade in rare connective tissue diseases such as systemic sclerosis and poly/dermatomyositis, with new biomarkers entering the clinical practice. Immunoprecipitation of protein and/or RNA components of the target autoantigens constitutes the gold standard method for the discovery of new autoantibodies in a screening setting but is considered time- and labor-intensive and, accordingly, is performed

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16

Coley, Rose Michelle. "The Association of Cancer Development in Patients with Systemic Lupus Erythematosus." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2148.

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The Association of Cancer Development in Patients with Systemic Lupus Erythematosus by Rose Michelle Coley MPH, Walden University, 2011 BS, University of Mount Olive, 2008 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Health Walden University March 2016 Both cancer and autoimmune diseases have been associated with numerous factors that may independently lead to the development of either disease. When these factors overlap the difficulty in assessing association is compounded. The numerous factors that are thought to cause system

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17

Kristjansdottir, Gudlaug Thora. "Genetic Variation and Expression of the IRF5 Gene in Autoimmune Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-99098.

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18

Kristjánsdóttir, Helga. "The PD-1 pathway and the complement system in systemic lupus erythematosus." Doctoral thesis, Uppsala universitet, Medicinsk genetik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107198.

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Autoimmune diseases occur in up to 3-5% of the general population and represent a diverse collection of diseases with regards to clinical manifestations. The unifying factor of autoimmune diseases is tissue and organ damage as a result of an immune response mounted against self-antigens. Systemic lupus erythematosus (SLE) is considered a prototype of human systemic autoimmune diseases. The etiology of SLE is as yet largely unknown, but both epidemiological and genetic data suggest an interplay between numerous and varying genetic and environmental factors. There is compelling evidence for a st

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Pfeifer, Maria A. "Self-help Support Groups: Choices in Participation Among Women Facing Systemic Lupus Erythematosus (SLE)." PDXScholar, 2005. https://pdxscholar.library.pdx.edu/open_access_etds/4793.

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This research study explored the experiences of 19 women who had been diagnosed with, or were still seeking the diagnosis of SLE (lupus) and their decisions regarding support group participation. The aim of this study was to evaluate the variety of factors influencing their choices in types and sources of support, their coping strategies and the reasons behind their decisions to either choose or not choose lupus support groups as a viable support resource. Those women identified as support groups attendees recalled a more emotion-focused response to their diagnosis and showed stronger reliance

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20

Sigurdsson, Snaevar. "Large-Scale Genotyping for Analysis of the Type I Interferon System in Autoimmune Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6792.

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21

Havarinasab, Said. "Effect of thimerosal on the murine immune system : especially induction of systemic autoimmunity." Doctoral thesis, Linköping : Univ, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-6315.

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22

Haynes, Eric E. "Identifying Common Genes from Rheumatoid Arthritis, Systemic Lupus, Multiple Sclerosis and Sjogrens Syndrome by Pooling Existing Microarray Data." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1374011043.

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23

Fan, Run. "The potential role of VH replacement in editing and generating autoreactive antibodies." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010r/fan.pdf.

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24

Lintner, Katherine E. "The Roles of Complement C4A and C4B Genetic Diversity and HLA DRB1 Variants on Disease Associations with Juvenile Dermatomyositis and Systemic Lupus Erythematosus." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460986052.

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25

Bettacchioli, Eléonore. "Identification de signatures biologiques pour la stratification des patients atteints de maladies auto-immunes systémiques." Electronic Thesis or Diss., Brest, 2025. http://www.theses.fr/2025BRES0013.

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Les maladies auto-immunes telles que la maladie de Sjögren (SjD) et le lupus érythémateux systémique (LES) posent des défis majeurs liés à une grande hétérogénéité clinique et biologique. Au travers d’analyses multi-omiques, cette thèse présente des objectifs multiples : (i) Caractériser le profil clinique et biologique des patients atteints de SjD selon leur profil d’auto-anticorps, (ii) Créer un outil en ligne facilitant l'accès et l'interprétation des données de transcriptomique du LES, et (iii) Analyser les interactions cellulaires dans le tissu rénal du LES. Dans la SjD, la stratification

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26

Kenyon, Karla. "The physiological and pathological regulation of apoptotic cell clearance /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 177-196). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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27

Wall, Gerard. "A study of anti-DNA autoantibodies in systemic lupus erythematosus." Thesis, University of Aberdeen, 1993. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU549890.

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Two anti-DNA autoantibody-secreting hybridomas, derived from murine models of the disease systemic lupus erythematosus (SLE), were provided. MAb-32, an IgG1, kappa, bound both single- (ss) and double-stranded (ds) DNA while mAb F-423, an IgG3, kappa, bound only ssDNA. F-423 also reacted with RNA and poly (dA) and its binding to ssDNA was found to be greatly amplified by histones. The VH genes of both antibodies and the VK gene of mAb F-423 were isolated by PCR, cloned, and sequenced. The two VH genes were also cloned into the pSW1.Fab expression vector and bacterial clones which showed DNA-bin

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28

Dawson, Luke Jonathan. "Salivary gland hypofunction and SjoÌˆgren's syndrome". Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250430.

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29

Sköldberg, Filip. "Studies of Autoantibodies in Systemic and Organ-Specific Autoimmune Disease." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3421.

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Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease, whereas autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal disorder characterized by combinations of organ-specific autoimmune manifestations including hypoparathyroidism and intestinal dysfunction, and may serve as a model for organ-specific autoimmunity. Autoantibodies directed against proteins expressed in the affected tissues are found in both diseases. From a chondrocyte cDNA expression library, we identified the protein AHNAK as an autoantigen in SLE. Anti-AHNAK antibodies were found in 29.

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Sköldberg, Filip. "Studies of autoantibodies in systemic and organ-specific autoimmune disease /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3421.

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31

Amel, Kashipaz Mohammad Rasoul. "Investigations of cytokine production by lymphocytes and autologous mixed lymphocyte reaction in relation to systemic lupus erythematosus." Thesis, Nottingham Trent University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272764.

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32

Sahlqvist, Anna-Stina. "Genetic Characterization of Chicken Models for Autoimmune Disease." Doctoral thesis, Uppsala universitet, Autoimmunitet, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182843.

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Autoimmune diseases are endemic, but the disease mechanisms are poorly understood. A way to better understand these are to find disease-regulating genes. However, this is difficult as the diseases are complex, with several genes as well as environmental factors influencing the development of disease. A way to facilitate the search for genes responsible for the diseases is to use comparative genomic studies. Animal models are relatively easy to analyze since control of environment and breeding are obtained. The University of California at Davies – line 200 (UCD-200) chickens have a hereditary d

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33

Peixoto, Tatiana Vasconcelos. "Aumento de células T CD4+CD69+ e redução de células T reguladoras CD4+CD25+FoxP3+ em camundongos com Lúpus Eritematoso Sistêmico (LES) induzido por pristane." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-14122015-152214/.

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Introdução: O Lúpus Eritematoso Sistêmico (LES) é uma doença autoimune multissistêmica de etiologia complexa que envolve fatores ambientais, genéticos e hormonais. É caracterizada pela produção de autoanticorpos e mediadores inflamatórios, ativação e proliferação de células T autorreativas e perda da autotolerância imunológica. Em pacientes com LES, a expressão do receptor primário de ativação CD69 é aumentada e a de células T supressoras/reguladoras (Treg) CD4+CD25+FoxP3+ é reduzida. O CD69 é essencial para ativação de células T CD4 autorreativas enquanto que as células Treg são importantes n

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34

Slingsby, Jason Hardwick. "The genetic basis of SLE in the BXSB mouse strain." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300455.

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35

Zhu, Jing. "The modulation of autoimmune disease progression in mouse models." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/100945.

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B cells play crucial roles in the development of the two human autoimmune diseases, type 1 diabetes (T1D) and systemic lupus erythematosus (SLE). In the past decade, numerous studies showed positive responses of B cell depletion therapies in these two diseases. However, the beneficial effects are temporary and accompanied with adverse events. In this dissertation, we aimed to identify novel targets for a better modulation of disease development using mouse models. These diseases have circulating autoantibodies that are mostly mutated with an IgG isotype, indicating B cells that are producing t

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36

Fitch, Megan. "The Effects of Air Pollution on the Intestinal Microbiota: A Novel Approach to Assess How Gut Microbe Interactions with the Environment Affect Human Health." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc984173/.

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This thesis investigates how air pollution, both natural and anthropogenic, affects changes in the proximal small intestine and ileum microbiota profile, as well as intestinal barrier integrity, histological changes, and inflammation. APO-E KO mice on a high fat diet were randomly selected to be exposed by whole body inhalation to either wood smoke (WS) or mixed vehicular exhaust (MVE), with filtered air (FA) acting as the control. Intestinal integrity and histology were assessed by observing expression of well- known structural components tight junction proteins (TJPs), matrix metallopeptidas

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37

Liu, Ke (Coco). "X Chromosome Gene Dosage in Autoimmune Disease Susceptibility and B Cell Development." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470753675.

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38

Melki, Isabelle. "Clinical and molecular characterisation of type I interferonopathies." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB122/document.

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Les interférons de type I (IFN I) sont des cytokines antivirales aux propriétés puissantes. L’induction, la transmission et la résolution de la réponse immunitaire engendrée par les IFN I est minutieusement régulée. Le concept d’interféronopathie de type I, récemment individualisé par notre équipe, repose sur l’hypothèse que certaines pathologies seraient secondaires au déséquilibre de ces voies de signalisation complexes et à la sécrétion excessive et inappropriée d’IFN I. L’inhibition de celle-ci par des thérapeutiques ciblées permettrait de valider cette hypothèse, si les symptômes allégués

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Reighard, Seth D. "A natural killer cell-centric approach toward new therapeutics for autoimmune disease." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273969849993.

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Prado, Danilo Marcelo Leite do. "Efeito de um programa de treinamento físico aeróbio supervisionado em crianças com lúpus eritematoso sistêmico juvenil." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-12022014-143034/.

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INTRODUÇÃO: O treinamento físico é considerado como um importante recurso terapêutico no que concerne a melhora da disfunção física observada em adultos com lúpus eritematoso sistêmico. Entretanto, até o momento não há estudos longitudinais que avaliaram os possíveis efeitos terapêuticos de um programa de treinamento físico em crianças e adolescentes com lúpus eritematoso sistêmico juvenil (LES-J). OBJETIVO avaliar a segurança e a eficácia de um de um programa de treinamento físico aeróbio supervisionado de 12 semanas no aumento da capacidade cardiorrespiratória em pacientes com LES-J. MÉTODOS

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Rossi, Giulio Antonino. "FOXP3, ICOS and ICOSL polymorphisms in an Italian population affected by systemic sclerosis." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/4031.

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Associated with substantial morbidity and mortality rates, systemic sclerosis (SSc) is an autoimmune disorder characterized by vasculopathy, inflammation, progressive perivascular and interstitial fibrosis. SSc pathogenesis is largely unknown, however strong evidences suggest that genetic predisposition may contribute to SSc development. Dysregulation of co-stimulatory and/or co-inhibitory signals, including ICOS signalling, can cause a breakdown of self-tolerance, thus leading to autoimmunity. Furthermore, ICOS has been linked to the function of Tregs. The aim of the present study was to inv

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Hayashi, Ana Paula Tanaka. "Eficácia e segurança da suplementação de creatina em pacientes com lúpus erimatoso sistêmico de início juvenil." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-07022014-144017/.

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Introdução: A suplementação de creatina tem surgido na literatura como uma potencial estratégia terapêutica não farmacológica em diversas condições caracterizadas por disfunções musculares e baixa massa muscular, incluindo as doenças reumatológicas pediátricas. O objetivo deste estudo foi avaliar a eficácia e a segurança da suplementação de creatina em pacientes com lúpus eritematoso sistêmico de início juvenil (LESJ). Métodos: Trata-se de um estudo duplo-cego, crossover, balanceado e controlado por placebo. Os voluntários (n = 15) foram randomizados em duas condições que receberam creatina ou

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Nwaneshiudu, Adaobi I. "The Role of Gamma-Delta TCR+ T-cells in the Pathogenesis of Systemic Sclerosis." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/11843.

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Microbiology and Immunology<br>Ph.D.<br>The human gamma-delta (gd) TCR+ T-cell subset may undergo specific antigen-driven activation and clonal expansion, in the context of systemic sclerosis (SSc) pathogenesis. The purpose of this study was; 1) To determine whether gd TCR+ T-cells are clonally expanded in skin biopsies and peripheral blood from patients with SSc; and 2) To develop approaches for identification of the antigens recognized by these clonally-expanded gd TCR+ T-cells. Total RNA was isolated from the skin biopsies and peripheral blood of patients with SSc (n=8). After cDNA synthesi

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Mesa, Annia. "Auto-antigenic Properties of the Spliceosome as a Molecular Tool for Diagnosing Systemic Lupus Erythematosus and Mixed Connective Tissue Disease Patients." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1126.

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Systemic Lupus Erythematosus (SLE) and Mixed Connective Tissue Disease (MCTD) are chronic, autoimmune disorders that target overlapping autoantigens and exhibit similar clinical manifestations. Despite 40 years of research, a reliable biomarker capable of diagnosing these syndromes has yet to be identified. Previous studies have confirmed that components of the U1 small nuclear ribonucleoprotein complex (U1 snRNP) such as U1A are 1000 fold more autoantigenic than any other nuclear component in SLE patients. Based on these findings, I hypothesize that models derived from the U1 snRNP autoantige

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Singthongthat, Wanwisa. "Analysis and validation of Interferon Regulatory Factor 5 (IRF5) on circulating microparticles in patients with SLE." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-415148.

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Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease that cause various inflammatory conditions in the body. The pathogenesis of this disease is yet unknown, and the diversity within the patients bring on major obstacle to clinical research for specific diagnostic markers. As a biomarker of SLE, both Interferon Regulatory Factor-5 (IRF5) and Microparticles (MP) have been suggested. Recently a study demonstrated higher concentration of IRF5+ MP in a small number of SLE patients compared to controls. Aim: The purpose of this study was to validate and analyze IRF5+ MPs in a

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Depaire, Agathe. "Altérations de l’efferocytose des macrophages induits par les cellules endothéliales : analyse des mécanismes et approche thérapeutique pour corriger la vasculopathie et la fibrose au cours de la sclérodermie systémique." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0481.

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La sclérodermie systémique (ScS) est une maladie auto-immune fibrotique chronique incurable. Le concept de réparation tissulaire non résolue, menant à une fibrose persistante, a émergé sur la base d'une inflammation stérile chronique qui transforme une réponse de réparation contrôlée en fibrose pathologique. La résolution efficace de l'inflammation repose notamment sur l’élimination des cellules apoptotiques par les macrophages (Mϕ) via l’efferocytose. Récemment, mon équipe a montré le rôle de la stimulation des cellules endothéliales microvasculaires (CEMV) cutanées par l’IL-1β dans la modula

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Schubert, David. "Arthritisinduktion durch Immunität gegen ein systemisch exprimiertes Autoantigen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2005. http://dx.doi.org/10.18452/15271.

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Ungefähr 1% der Bevölkerung der westlichen Welt leidet an rheumatoider Arthritis (RA). In einem T-Zellrezeptor transgenen Mausmodell, dem K/BxN Modell, wird die ubiquitär exprimierte Glukose-6-phosphat Isomerase (G6PI) von autoreaktiven T- und B-Zellen erkannt. Diese Mäuse entwickeln spontan eine antikörpervermittelte Arthritis, die viele Gemeinsamkeiten mit der humanen RA aufweist. In dieser Arbeit wurde untersucht, ob die Immunisierung mit G6PI eine Arthritis auch in nicht-transgenen Mäuse induzieren kann. Die Immunisierung mit heterologer humaner G6PI führte zur Entwicklung einer peripheren

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Abbud, Filho Mario. "Microquimerismo fetal em pacientes com lupus eritematoso sistêmico: uma contribuição para o estudo da fisiopatologia das doenças auto-imunes." Faculdade de Medicina de São José do Rio Preto, 2006. http://bdtd.famerp.br/handle/tede/237.

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Made available in DSpace on 2016-01-26T12:51:54Z (GMT). No. of bitstreams: 1 marioabbudfilho_tese.pdf: 593929 bytes, checksum: 5a51471e6a2867571b8d0d10243eafa1 (MD5) Previous issue date: 2006-12-01<br>Systemic lupus erythematosus (LES) is a serious systemic autoimmune disease of which the pathogenesis remains elusive. Bi-directional cell traffic during pregnancy gives rise to fetal microchimerism (FMC). There is accumulating evidence suggesting that FMC can cause or exacerbate autoimmunity. Objetive. To determine the incidence of FMC in LES patients (pts) and to assess the effect of pregnanc

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TINAZZI, Elisa. "Role of endothelial cells in autoimmune systemic diseases." Doctoral thesis, 2008. http://hdl.handle.net/11562/337614.

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Il progetto di ricerca prevedeva lo studio di alcuni aspetti del ruolo svolto dalle cellule endoteliali in due malattie autoimmuni sistemiche quali la Sclerosi Sistemica Progressiva, alla cui patogenesi la componente vascolare gioca un ruolo fondamentale e l’Artrite Reumatoide, ove l’endotelio riveste notevole importanza nel reclutamento di cellule del sistema immune nella membrana sinoviale, sede della flogosi cronica reumatoide.<br>This research project aimed at studying some aspects of the role played by endothelial cells in two different systemic autoimmune disorders, such as Progre

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Ribeiro, Francisco de Sousa Sebastião Alexandre. "Anti-Ro/SSA and the development of hematological malignancy in systemic autoimmune diseases." Master's thesis, 2021. http://hdl.handle.net/10451/52026.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2021<br>Os auto-anticorpos estão associados a um número considerável doenças autoimunes. O anticorpo anti-Ro/SSA faz parte deste grupo vasto de anticorpos, podendo encontrar-se em doentes com Síndrome de Sjögren (SS) e Lupus Eritematoso Sistémico (LES), entre outros. O anticorpo anti-Ro tem como alvo o antigénio Ro que se compõe de duas proteínas diferentes, Ro60 e Ro52. Tem sido amplamente reconhecido na literatura que doentes com patologia autoimune como LES e SS têm um risco acrescido d

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