Log in

Relevant bibliographies by topics / T-type calcium channel inhibitors / Dissertations / Theses

To see the other types of publications on this topic, follow the link: T-type calcium channel inhibitors.

Dissertations / Theses on the topic 'T-type calcium channel inhibitors'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 32 dissertations / theses for your research on the topic 'T-type calcium channel inhibitors.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Anhettigama, Gamaralalage Medha Jaimini Gunaratna. "Design, synthesis and bio-evaluation of piperidines and CGRP peptides; Synthesis of substituted 6-(dimethylamino)-2-phenylisoindolin-1-ones for the inhibition of luciferase." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38204.

Full text

Abstract:

Doctor of Philosophy<br>Department of Chemistry<br>Duy H. Hua<br>Three research projects are described in this dissertation, and they are: (i) discovery of piperidine derivatives as T-type calcium channel inhibitors for the treatment of epilepsy and neuropathic pain and as protein disulfide isomerase inhibitors for the treatment of influenza viral infection; (ii) discovery of peptide-based calcitonin gene-related peptide receptor antagonists for the treatment of inflammatory pain; and (iii) synthesis of substituted 6-(dimethylamino)-2-phenylisoindolin-1-ones for the inhibition of luciferase.

APA, Harvard, Vancouver, ISO, and other styles

2

Francois, Amaury. "Distributions et fonctions du canal Calcique Cav3.2 dans les voies somatosensorielles." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20036/document.

Full text

Abstract:

Le traitement et la gestion de la douleur sont depuis toujours une priorité pour le corps médical. Malgré leur importance pour la qualité de vie, les analgésiques couramment utilisés possèdent un ratio bénéfice/risque faible. La recherche de nouveaux concepts thérapeutiques pour lutter contre la douleur est donc une priorité. Afin de répondre à ce besoin, il faut d'abord comprendre les mécanismes de la perception de la douleur ainsi que, plus globalement, ceux permettant de percevoir son environnement. Dans ce contexte, de nombreuses études ont mis en évidence l'implication du canal calcique à

APA, Harvard, Vancouver, ISO, and other styles

3

Florczak, Kaya. "Wnt/β-Catenin Signalling Inhibits T-Type Calcium Channels in Cardiomyocytes". Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41983.

Full text

Abstract:

Background: The Wnt/β-catenin signalling pathway is activated in arrhythmogenic heart diseases such as myocardial infarction and heart failure, but it is unclear if the pathway regulates cardiac ion channels and thus may play a role in arrhythmogenesis. Previous PCR array screening from our lab showed that the transcript level of the T-type calcium channel gene Cacna1g was reduced in primary culture of neonatal rat ventricular myocytes (NRVMs) after activation of Wnt/β-catenin signalling with Wnt3a protein (100 ng/ml) or a small molecule activator of the pathway, CHIR (3 µM) (n=3, p<0.01). In

APA, Harvard, Vancouver, ISO, and other styles

4

NIWA, Noriko, Kenji YASUI, and Itsuo KODAMA. "Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes." Research Institute of Environmental Medicine, Nagoya University, 2002. http://hdl.handle.net/2237/2792.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Wang, Fang. "DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?" Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/214814.

Full text

Abstract:

Physiology<br>Ph.D.<br>Cardiovascular disease remains the number one cause or mortally in the western world. Heart failure is the most rapidly growing cardiovascular disease (Hobbs, 2004; Levy, et al., 2002). Heart failure, by definition, is progressive deteriorating function of the heart due to progressive cardiac myocytes loss. Though after decades of endeavor of searching the pathophysiology and treatments for heart failure, it remains highly lethal. Therefore, it is vital to find novel therapies to help treat such chronic disease. Replace the lost cardiomyocyte with new ones could restore

APA, Harvard, Vancouver, ISO, and other styles

6

Foster, Nicholas E. V. "Whole cell and single channel analysis of cloned T-type calcium channel functionally expressed in HEK cells." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29435.

Full text

Abstract:

I examined the kinetic properties of macroscopic and single channel currents produced by an isoform of the rat CaV3.1 T-type voltage-gated calcium channel, expressed in HEK-293 cells. Whole cell currents were measured in 2 mM extracellular Ca2+, and single channel activity was recorded from cell-attached patches in 120 mM Ba2+. We found that macroscopic rates of activation, deactivation, inactivation, and recovery from inactivation each have voltage-dependent and voltage-independent components. Single channels opened and closed rapidly in bursts before inactivating, with a mean open time of 1

APA, Harvard, Vancouver, ISO, and other styles

7

Hildebrand, Michael Earl. "Differential modulation of T-type voltage gated calcium channels by G-protein coupled receptors." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1019.

Full text

Abstract:

T-type voltage-gated calcium (Ca2+) channels play critical roles in controlling neuronal excitability, firing patterns, and synaptic plasticity, although the mechanisms and extent to which T-type Ca2+ channels are modulated by G-protein coupled receptors (GPCRs) remains largely unexplored. Investigations into T-type modulation within native neuronal systems have been complicated by the presence of multiple GPCR subtypes and a lack of pharmacological tools to separate currents generated by the three T-type isoforms; Cav3.1, Cav3.2, and Cav3.3. We hypothesize that specific Cav3 subtypes play u

APA, Harvard, Vancouver, ISO, and other styles

8

Li, Yingxin. "THE ROLES OF Cav3.1/a1G T-TYPE CALCIUM CHANNEL IN HEART RATE GENERATION, REGULATION AND CARDIAC ARRHYTHMIAS." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/151806.

Full text

Abstract:

Physiology<br>Ph.D.<br>T-type Ca²+ channels (TTCCs) are expressed in cardiac pacemaker cells and conduction system of mammals. However, the roles of TTCCs in heart rate (HR) generation and regulation, and arrhythmias are not well understood. In the mouse, the major TTCC expressed in the heart is Cav3.1/a1G, and therefore we used Cav3.1/ 1G transgenic (TG) and knockout (KO) mice respectively to define the role of TTCC in the heart rate generation, regulation and arrhythmias. Telemetric (conscious) and surface (anesthetized) electrocardiogram (ECG) were used to determine the baseline HR and the

APA, Harvard, Vancouver, ISO, and other styles

9

Cunningham, Jonathan. "Differential effects of the t-type calcium channel antagonist, Z944, on behaviours associated with amphetamine and morphine addiction." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59529.

Full text

Abstract:

Mixed L-/T-type calcium channel antagonists attenuate morphine- and amphetamine induced conditioned place preference (CPP). Subtype specific antagonists for T-type calcium channels attenuate nicotine-reinforced behaviours in rats. This thesis investigated the effects of a novel T-type calcium channel antagonist, Z944, on the acquisition, expression, and reinstatement of amphetamine and morphine CPP. Furthermore, we examined Z944 for aversive or rewarding properties, and determined changes in locomotion with Z944 alone and in conjunction with amphetamine or morphine. CPP was induced with either

APA, Harvard, Vancouver, ISO, and other styles

10

Mulatz, Kirk James. "A PDZ-3 mediated physical and functional interaction between the CaV3.2 T-type calcium channel and neuronal nitric oxide synthase." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/43790.

Full text

Abstract:

T-type voltage-gated calcium channels are expressed throughout the central and peripheral nervous systems as well as in several non-neuronal tissues and contribute to variety of functions such as neuronal excitability, intracellular calcium influx, shaping action potentials, pace-making activity, hormone secretion, and neurotransmitter release. Of the three T-type channel isoforms, Cav3.2 is uniquely sensitive to redox modulation with oxidizing reagents inhibiting and reducing compounds enhancing channel activity. This modulation has been shown to alter firing patterns of reticular thalamic ne

APA, Harvard, Vancouver, ISO, and other styles

11

Waite, Sarah. "Regulation of myometrial contractility : defining the contribution of the MaxiK potassium channel and the L- and T-type calcium channels." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/11621/.

Full text

Abstract:

This thesis describes a comprehensive study investigating the roles of the MaxiK potassium channel (KCNMA1), L-Type calcium channel (CACNA1C) and T-Type calcium channel (CACNA1G) in the maintenance of quiescence (relaxed myometrium), the preparation for parturition (non-contracting myometrium) and the regulation of the co-ordinated contractions characteristic of parturition itself (contracting myometrium). The role of these channels was investigated using primary human myometrial cell cultures under relaxed, non-contracting and contracting conditions. Protein studies revealed changes in both t

APA, Harvard, Vancouver, ISO, and other styles

12

Albrecht, Julie [Verfasser]. "The effect of the KV7/KCNE 1 inhibitor JNJ 303 on heart slices and the L-type calcium channel of cardiac cells / Julie Albrecht." Köln : Deutsche Zentralbibliothek für Medizin, 2017. http://d-nb.info/1130707415/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Pötschke, Christina [Verfasser]. "Compensatory T-type calcium channel activity alters the dopamine D2-autoreceptor response of dopaminergic substantia nigra neurons from juvenile CaV1.3 KO mice / Christina Pötschke." Ulm : Universität Ulm. Fakultät für Naturwissenschaften, 2014. http://d-nb.info/1057938610/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Barceló, Gómez Carla. "Modulació de l'autofàgia com a nova estratègia terapèutica en el melanoma. Estudi de les resistències a fàrmacs convencionals." Doctoral thesis, Universitat de Lleida, 2019. http://hdl.handle.net/10803/666908.

Full text

Abstract:

El melanoma és una neoplàsia maligna derivada dels melanòcits que, un cop disseminada, desenvolupa una gran resistència a la quimioteràpia i s’associa amb un mal pronòstic. Al voltant del 50% dels melanomes porten la mutació BRAFV600E. Els inhibidors de la quinasa BRAF, com el Vemurafenib, redueixen la càrrega tumoral en el melanoma disseminat. No obstant això, la resistència adquirida es produeix molt sovint i els tumors comencen a progressar sota el tractament. En estudis anteriors, hem demostrat que els canals de calci tipus T (TTCCs) estan sobreexpressats en cèl·lules de melanoma i tenen u

APA, Harvard, Vancouver, ISO, and other styles

15

Voisin, Tiphaine. "Développement d’une souris modèle pour l’étude de la modulation metal/redox du canal calcique Cav3.2 dans l’excitabilité neuronale et dans les voies de la douleur." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT037.

Full text

Abstract:

Les canaux de type T Cav3.2 sont des canaux calciques activés pour de faibles dépolarisations membranaires. Ils ont un rôle important dans la régulation de l’excitabilité neuronale, particulièrement dans les neurones des ganglions rachidiens dorsaux (DRG) où ils sont impliqués dans la transmission de la douleur. Il est établi que les canaux Cav3.2, natifs et recombinants, sont inhibés par de faibles concentrations de métaux divalents tels que le zinc et le nickel et qu’ils sont modulés par des agents oxydo-réducteurs. In vitro, la mutation ponctuelle de l’histidine 191 en glutamine (H191Q) dim

APA, Harvard, Vancouver, ISO, and other styles

16

Wolfe, Joshua Todd. "Molecular mechanisms of T-type calcium channel regulation /." 2003. http://wwwlib.umi.com/dissertations/fullcit/3097262.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

LIN, YI-JYUN, та 林宜君. "Regulation of Human Cav3.2 T-type Calcium Currents by Calcium Channel γ Subunits". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/rncbt2.

Full text

Abstract:

碩士<br>東海大學<br>生命科學系<br>105<br>The current conducted by calcium channels mediate many important cellular processes. The dysfunction of calcium channel can cause disorders including epilepsy, arrhythmia and pulmonary hypertension. The voltage-gated calcium channel has up to four subunits (α1, β, α2δ and γ). The α1 subunit forms the calcium-selective channel pore. The β and α2δ subunits help the α1 subunit insert into the plasma membrane, increasing channel open probability and decreasing channel inactivation. In contrast, γ subunits are much less studied. Recently, the γ subunits have added two

APA, Harvard, Vancouver, ISO, and other styles

18

Hsu, Shao-Chun, and 許紹君. "Transcriptional Regulation of T-type Calcium Channel Cav3.2 During the Cardiac Hypertrophy." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/02581012567545921845.

Full text

Abstract:

博士<br>國立陽明大學<br>生化暨分子生物研究所<br>102<br>The Cav3.2 T-channel plays a pivotal role in inducing calcineurin/nuclear factor of activated T cell (NFAT) signaling during cardiac hypertrophy. Because calcineurin/NFAT signaling is induced early after pressure overload, we hypothesized that Cav3.2 is induced by an early signal. Our aim is to investigate when and how Cav3.2 is induced during cardiac hypertrophy. The evolutionary conserved promoter Cav3.2-3500 from mouse genome was validated to express the reporter gene as endogenous Cav3.2 in cell lines and transgenic (Tg; Cav3.2-3500-Luc) mice. The early

APA, Harvard, Vancouver, ISO, and other styles

19

Chieng, Hock-Ling. "Cav3.2 T-type Calcium Channel Participates in Swimming-induced Physiological Cardiac Hypertrophy." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2507200802074600.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Chieng, Hock-Ling, and 錢學霖. "Cav3.2 T-type Calcium Channel Participates in Swimming-induced Physiological Cardiac Hypertrophy." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/89729817816596845811.

Full text

Abstract:

碩士<br>國立臺灣大學<br>動物學研究所<br>96<br>Voltage-gated T-type Ca2+ current (T-current) is temporarily recorded in cardiac myocytes during embryonic and postnatal period in some rodents (Leuranguer et al., 2000; Niwa et al., 2004) and was found linearly correlated with growth rate in rat of both sexes (Xu and Best, 1992). The growth of body weight and heart size has been well studied to be affected by chronically elevated growth hormone (GH) through the action of Insulin-like growth factor-1 (IGF-1) (Boguszewski et al., 1997; Ong et al., 2002; Xu and Best, 1991). Moreover, through the approach of patch-

APA, Harvard, Vancouver, ISO, and other styles

21

Ho, I.-Lin, and 何宜霖. "Microarray Dataset Analysis of the Cav3.2 T-type Calcium Channel Knockout Mouse Strain." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/90652734788557410845.

Full text

Abstract:

碩士<br>國立中興大學<br>資訊管理學系所<br>100<br>Different brain areas are responsible for specific functions of learning and memory. Among them, the hippocampus plays an important role in forming spatial, episodic and long-term memory. The α1H T-type Ca channel (Cav3.2) triggers many intracellular biochemical events, including muscle contraction, gene expression or hormones and neurotransmitter secretion. It has been demonstrated that the α1H T-type Ca2+ channel (Cav3.2) is highly expressed in the hippocampus and where it plays a critical role in hippocampal‐dependent learning. This thesis analyzed genome-w

APA, Harvard, Vancouver, ISO, and other styles

22

林鑫秀. "The role of Cav3.2 T-type calcium channel in mouse tracheal cartilage development." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/55259284798925057885.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Chen, Mu-Long, and 陳木龍. "Labedipinedilol-A inhibits L-type calcium channels in rat cerebral artey myocytes." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/38731055018616018151.

Full text

Abstract:

碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>93<br>Labedipinedilol-A has been described to have ��/��-adrenoceptor and calcium channel blocking activities, and to inhibit the proliferation of vascular smooth muscle cells. However, a direct evidence of calcium currents inhibition by labedipinedilol-A has not yet been documented. This study is to examine the effects of labedipinedilol-A on L-type calcium currents (ICa,L). We used the conventional whole cell patch-clamp technique to investigete Ba2+ currents (IBa) through L-type Ca2+ channels in rat cerebral artery myocytes. The IBa was reduced by nifedipine (1 �

APA, Harvard, Vancouver, ISO, and other styles

24

Su, Che-Yen, and 蘇哲彥. "The study of PTSD by Cav3.2 T-type Calcium Channel Knockout Mouse Microarray Dataset Analysis." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/52751510056459992517.

Full text

Abstract:

碩士<br>國立中興大學<br>基因體暨生物資訊學研究所<br>102<br>Post-traumatic stress disorder (PTSD) is a mental disorder, results from the exposure to huge post-traumatic stress. The disease process will also influence the different levels of gene expression in the brain. Mice after electric shock training will produce contextual memory-related experience, but it also constitutes a of PTSD condition－Experience major trauma. Trace fear conditioning test with mice model is also PTSD-related experiment commonly used operations. Cav3.2 T-type calcium channel was associated with contextual memory, so use knockout operati

APA, Harvard, Vancouver, ISO, and other styles

25

Elies, Jacobo, E. Johnson, J. P. Boyle, J. L. Scragg, and C. Peers. "H2S does not regulate proliferation via T-type Ca2+ channels." 2015. http://hdl.handle.net/10454/12205.

Full text

Abstract:

No<br>T-type Ca2+ channels (Cav3.1, 3.2 and 3.3) strongly influence proliferation of various cell types, including vascular smooth muscle cells (VSMCs) and certain cancers. We have recently shown that the gasotransmitter carbon monoxide (CO) inhibits T-type Ca2+ channels and, in so doing, attenuates proliferation of VSMC. We have also shown that the T-type Ca2+ channel Cav3.2 is selectively inhibited by hydrogen sulfide (H2S) whilst the other channel isoforms (Cav3.1 and Cav3.3) are unaffected. Here, we explored whether inhibition of Cav3.2 by H2S could account for the anti-proliferative effec

APA, Harvard, Vancouver, ISO, and other styles

26

Jung, Yu-Ling, та 鍾玉鈴. "Application of statistical methods on microarray analysis of the α1H T-type calcium channel knockout mice". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/f65hqh.

Full text

Abstract:

碩士<br>國立中興大學<br>基因體暨生物資訊學研究所<br>100<br>This thesis aims to improve the efficiency and accuracy of microarray analysis on mice brains. Of all the voltage-gated calcium channels, the α1H T-type Ca2+ channel(Cav3.2) is highly expressed in the hippocampus, where is correlated with contextual learning and spatial memory. It has been demonstrated that the Cav3.2 gene plays a critical role in hippocampal-dependent learning. However, the underlying molecular mechanism is yet unclear. Microarray hybridizations have been done for isolated hippocampi of the Cav3.2 knockout mice in order to screen for gen

APA, Harvard, Vancouver, ISO, and other styles

27

Wang, Li-Ya, and 王莉雅. "A Bioinformatic Study on The Right-Hippocampal Microarray Datasets of Cav3.2 T-type Calcium Channel Knockout Mouse Strain." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/19634656026917390627.

Full text

Abstract:

碩士<br>國立中興大學<br>資訊管理學系所<br>100<br>The purpose of this study was to compare differential gene expression for the right hemisphere of Cav3.2 gene knockout mouse and the wild type based on genome wide microarray datasets after contextual trace fear conditioning. First, Paired-samples t-test was conducted to confirm whether there were significant differences of gene expression prior to and after experimental training. Secondly, linear regression analysis was applied to select target genes which have statistical significant differences in gene expression. After that, the target genes were then put

APA, Harvard, Vancouver, ISO, and other styles

28

Duckles, H., H. E. Boycott, M. M. Al-Owais, et al. "Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels." 2014. http://hdl.handle.net/10454/12206.

Full text

Abstract:

Yes<br>Induction of the antioxidant enzyme heme oxygenase-1 (HO-1) affords cellular protection and suppresses proliferation of vascular smooth muscle cells (VSMCs) associated with a variety of pathological cardiovascular conditions including myocardial infarction and vascular injury. However, the underlying mechanisms are not fully understood. Over-expression of Cav3.2 T-type Ca2+ channels in HEK293 cells raised basal [Ca2+]i and increased proliferation as compared with non-transfected cells. Proliferation and [Ca2+]i levels were reduced to levels seen in non-transfected cells either

APA, Harvard, Vancouver, ISO, and other styles

29

Liao, Yi-Fang, and 廖儀芳. "Involvement of the T-type Calcium channel in discharge pattern and interaction of ventral posterior and reticular thalamic neurons." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/06467521218547314758.

Full text

Abstract:

博士<br>國立臺灣大學<br>動物學研究所<br>99<br>Low-threshold T-type calcium channels (T-channels) are critically important in the generation of thalamic burst activities. Different subtypes of T-channel distributed differentially in thalamic ventroposterior nucleus (VP, Cav3.1) and reticular thalamic nucleus (RT, Cav3.2 and Cav3.3). Furthermore, T-channel knockout (KO) mice showed contrast nociceptive behaviors, such that an increase was seen in Cav3.1 KO and a decrease in Cav3.2 KO. Considering the important role in sensory relay function of VP neuron and it’s densely reciprocal connection to GABAergic RT,

APA, Harvard, Vancouver, ISO, and other styles

30

Oudit, Gavin Y. "Role of L-type Ca2+ channel and oxidative stress in the pathogenesis of iron-overload cardiomyopathy : calcium channel blockers and taurine as potential therapies." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=371012&T=F.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Senatore, Adriano. "Alternative splicing of Lymnaea Cav3 and NALCN ion channel genes serves to alter biophysical properties, membrane expression, and ion selectivity." Thesis, 2012. http://hdl.handle.net/10012/6926.

Full text

Abstract:

Evidence is presented that Lymnaea contains homologues for mammalian Cav3 and NALCN 4-domain ion channels, which retain key amino acid sequence motifs that differentiate these channels from other 4-domain types. Molecular cloning and heterologous expression of the first invertebrate Cav3 channel cDNA from Lymnaea confirms that it indeed is a true homologue to mammalian Cav3 channels, retaining some hallmark biophysical and pharmacological features1. Interestingly, the Lymnaea Cav3 channel gene also exhibits alternative splicing that is conserved with mammalian Cav3.1 and Cav3.2 channels, with

APA, Harvard, Vancouver, ISO, and other styles

32

Guan, Wendy. "Domain II (S5-P) region in Lymnaea T-type calcium channels and its role in determining biophysical properties, ion selectivity and drug sensitivity." Thesis, 2014. http://hdl.handle.net/10012/8507.

Full text

Abstract:

Invertebrate T-type calcium channels cloned from the great pond snail, Lymnaea Stagnalis (LCav3) possess highly sodium permeant ion channel currents by means of alternative splicing of exon 12. Exon 12 is located on the extracellular turret and the descending helix between segments 5 and segments 6, upstream of the ion selectivity filter in Domain II. Highly-sodium permeant T-type channels are generated without altering the selectivity filter locus, the primary regulatory domain known to govern ion selectivity for calcium and sodium channels. Comparisons of exon 12 sequences between invert

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!