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Journal articles on the topic 'Tandem Cyclization'

Author: Grafiati

Published: 6 September 2023

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1

Rae Kim, Hyoung, Su Yeon Jo, Hyoung Cheul Kim, and Dong Ju Jeon. "Tandem Cyclization of Phytosphingosine." HETEROCYCLES 55, no. 6 (2001): 1127. http://dx.doi.org/10.3987/com-01-9187.

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2

Nookaraju, U., Eeshwaraiah Begari, and Pradeep Kumar. "Total synthesis of (+)-monocerin via tandem dihydroxylation-SN2 cyclization and a copper mediated tandem cyanation–lactonization approach." Org. Biomol. Chem. 12, no. 31 (2014): 5973–80. http://dx.doi.org/10.1039/c4ob00965g.

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A simple and novel synthesis of (+)-monocerin was achieved from 3-buten-1-ol employing HKR, Julia olefination, intramolecular tandem Sharpless asymmetric dihydroxylation-S<sub>N</sub>2 cyclization and a novel copper mediated tandem cyanation–cyclization as the key steps.

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3

Yuan, Lang, and Hai-Tao Yu. "A Density Functional Theory Investigation of the Tandem Radical Cyclization of 1-[2-Yl-3-(2-Methoxyphenyl)-prop-2-enyl]-6-oxo-1,6-dihydropyridine-2-carbonitrile." Australian Journal of Chemistry 69, no. 3 (2016): 319. http://dx.doi.org/10.1071/ch15369.

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A density functional theory investigation of the mechanism of the titled reaction has been performed. The results suggest that the compound 1-[2-iodo-3-(2-methoxyphenyl)-prop-2-enyl]-6-oxo-1,6-dihydropyridine-2-carbonitrile would rather be converted into the titled free radical by deiodination than go by way of a Diels–Alder cycloaddition and HI-elimination to access the experimentally observed product. The deiodination of the radical precursor is followed by tandem radical cyclizations and hydrogen-loss oxidations to generate tetracyclic non-radical products. The mechanism of the tandem react

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4

Trost, Barry M., and Serge Mignani. "Tandem palladium-catalyzed elimination-cyclization." Journal of Organic Chemistry 51, no. 18 (1986): 3435–39. http://dx.doi.org/10.1021/jo00368a005.

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5

Huang, Ji-Rong, Liu Qin, Yu-Qin Zhu, Qiang Song, and Lin Dong. "Multi-site cyclization via initial C–H activation using a rhodium(iii) catalyst: rapid assembly of frameworks containing indoles and indolines." Chemical Communications 51, no. 14 (2015): 2844–47. http://dx.doi.org/10.1039/c4cc07125e.

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Tandem multi-site cyclization triggered by Rh(iii)-catalyzed C–H activation has been achieved for highly efficient synthesis of spirocycle indolin-3-one (C2-cyclization), benzo[a]carbazole (C3-cyclization) and an unusual indoxyl core (N1-cyclization).

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6

Cao, Ziping, Shan Li, Jie Li та ін. "Gold-catalyzed π-directed regioselective cyclization of bis(o-alkynyl benzyl alcohols): rapid access to dihydroisobenzofuran derivatives". New Journal of Chemistry 40, № 10 (2016): 8211–15. http://dx.doi.org/10.1039/c6nj02066f.

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7

Huo, Xing, Jizhong Fang, Lige Xu, and Bowen Fang. "Synergistic Oxidative Coupling–[3+2] Cyclization of Quinones with Olefins Promoted by Cerium(IV) Sulfate Tetrahydrate." Synlett 28, no. 12 (2017): 1491–95. http://dx.doi.org/10.1055/s-0036-1588781.

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A cerium(IV) sulfate tetrahydrate promoted oxidative cyclization of quinones with olefins is developed. It proceeds through a tandem [3+2]-cyclization–oxidative coupling–[3+2]-cyclization process, in which tetrahydrobenzodifurans were conveniently constructed in high yields. Moreover, this method exhibits a good functional-group tolerance and scalability.

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8

Błocka, Aleksandra, Paweł Woźnicki, Marek Stankevič, and Wojciech Chaładaj. "Pd-catalyzed intramolecular addition of active methylene compounds to alkynes with subsequent cross-coupling with (hetero)aryl halides." RSC Advances 9, no. 68 (2019): 40152–67. http://dx.doi.org/10.1039/c9ra08002c.

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A tandem cyclization/coupling of acetylenic active methylene compounds with aryl halides features broad scope and excellent functional group compatibility. Mechanistic studies identified 5-exo-dig cyclization as the rate limiting step.

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9

Hou, Yunlei, Mingze Qin, Xiuxiu Yang, et al. "Palladium-catalyzed three-component tandem cyclization of buta-2,3-dien-1-ol, aryl iodides, and imines: an efficient protocol for the synthesis of oxazolidine derivatives." RSC Advances 7, no. 12 (2017): 7401–5. http://dx.doi.org/10.1039/c6ra27993g.

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An efficient three-component tandem cyclization reaction for the synthesis of highly substituted oxazolidines was achieved through the Pd<sup>0</sup>-catalyzed cyclization of buta-2,3-dien-1-ol with aryl iodides and imines.

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10

Deng, Danfeng, Dayun Huang, Xiangyu Sun, and Biwen Gao. "Recent Advances in the Tandem Difunctionalization of Alkynes: Mechanism-Based Classification." Synthesis 53, no. 19 (2021): 3522–34. http://dx.doi.org/10.1055/a-1486-2158.

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AbstractRecent advances on the tandem difunctionalization of alkynes in the last decade (2010–2020) are summarized into five categories based on the type of mechanism: (1) radical addition and coupling for the synthesis of polysubstituted ketones and alkenes, (2) electrophilic addition of alkynes, (3) reactions mediated by haloalkynes or copper acetylides, (4) the preparation of cyclic compounds via radical processes, palladium-catalyzed reactions or conjugate additions, and (5) cyclic compounds as intermediates in ring openings. Herein, radical, electrophilic and nucleophilic reactions are di

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11

Oguri, Hiroki, Haruki Mizoguchi, Hideaki Oikawa, et al. "Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization." Beilstein Journal of Organic Chemistry 8 (June 22, 2012): 930–40. http://dx.doi.org/10.3762/bjoc.8.105.

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By emulating the universal biosynthetic strategy, which employs modular assembly and divergent cyclizations, we have developed a four-step synthetic process to yield a collection of natural-product-inspired scaffolds. Modular assembly of building blocks onto a piperidine-based manifold6, having a carboxylic acid group, was achieved through Ugi condensation,N-acetoacetylation and diazotransfer, leading to cyclization precursors. The rhodium-catalyzed tandem cyclization and divergent cycloaddition gave rise to tetracyclic and hexacyclic scaffolds by the appropriate choice of dipolarophiles insta

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12

Roy, Snigdha. "Prins-Friedel-Crafts Cyclization: Synthesis of Diversely Functionalized Six- Membered Oxacycles." Current Organic Chemistry 25, no. 5 (2021): 635–51. http://dx.doi.org/10.2174/1385272825666210114105020.

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Prins cyclization is a well-established synthetic protocol to generate a wide range of important oxygen heterocycles. It is a cyclization reaction performed by an oxocarbenium ion that undergoes an intramolecular pi-bond attack to construct a new carbon-carbon bond. When this cyclization process is conjugated with Friedel-Crafts reaction, it further expands the synthetic potential by fabricating two different carbon-carbon bonds in one single reaction. Different acid catalysts mediated the coupled Prins-Friedel-Crafts reaction which is conducted both in stepwise as well as in tandem fashion. I

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13

Aronica, Laura, and Gianluigi Albano. "Cyclization Reactions for the Synthesis of Phthalans and Isoindolines." Synthesis 50, no. 06 (2018): 1209–27. http://dx.doi.org/10.1055/s-0037-1609175.

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Oxygen and nitrogen heterocycles are present in a vast number of natural substrates and biologically active molecules. In particular, phthalan and isoindoline subunits are found in many classes of products such as antibiotics, antioxidants, antimycotics, pigments, and fluorophores. Therefore several procedures dedicated to the construction of these heterocycles have been developed. In this review, a detailed analysis of the literature data regarding the synthesis of these nuclei via cyclization reactions is reported.1 Introduction2 Phthalans2.1 Oxa-Pictet–Spengler Reaction2.2 Garratt–Braverman

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14

Zhang, Wei, Wenlong Yu, Qiangqiang Yan, Zhanxiang Liu, and Yuhong Zhang. "Synthesis of substituted oxazoles via Pd-catalyzed tandem oxidative cyclization." Organic Chemistry Frontiers 4, no. 12 (2017): 2428–32. http://dx.doi.org/10.1039/c7qo00517b.

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15

Pan, Yixiao, Changjun Chen, Xin Xu, et al. "Metal-free tandem cyclization/hydrosilylation to construct tetrahydroquinoxalines." Green Chemistry 20, no. 2 (2018): 403–11. http://dx.doi.org/10.1039/c7gc03095a.

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B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-Catalyzed tandem cyclization/hydrosilylation for the step-economical construction of 1,2,3,4-tetrahydroquinoxalines from readily available starting materials has been developed.

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16

Bailey, William F., and Timo V. Ovaska. "Tandem Cyclization of Enynyl and Diynyl Alkyllithiums." Chemistry Letters 22, no. 5 (1993): 819–20. http://dx.doi.org/10.1246/cl.1993.819.

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17

Choi, Kyoungmin, Jung Min Joo, and Chulbom Lee. "Rhodium-catalyzed tandem addition–cyclization of alkynylimines." Tetrahedron 71, no. 35 (2015): 5910–17. http://dx.doi.org/10.1016/j.tet.2015.05.009.

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18

Bailey, William F., and Kyllikki Rossi. "Tandem anionic cyclization approach to polycarbocyclic products." Journal of the American Chemical Society 111, no. 2 (1989): 765–66. http://dx.doi.org/10.1021/ja00184a073.

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19

Kariv-Miller, Essie, Hatsuo Maeda, and Franco Lombardo. "Reductive tandem cyclization of allyl pentenyl ketones." Journal of Organic Chemistry 54, no. 17 (1989): 4022–24. http://dx.doi.org/10.1021/jo00278a007.

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20

Ghosh, Tirthankar, and Harold Hart. "Scope of tandem cycloadditon/radical cyclization methodology." Journal of Organic Chemistry 54, no. 21 (1989): 5073–85. http://dx.doi.org/10.1021/jo00282a022.

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21

Ohno, Hiroaki, Kumiko Miyamura, Yusuke Takeoka, and Tetsuaki Tanaka. "Palladium(0)-Catalyzed Tandem Cyclization of Allenenes." Angewandte Chemie International Edition 42, no. 23 (2003): 2647–50. http://dx.doi.org/10.1002/anie.200351011.

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22

Curran, DP, and SN Sun. "Tandem Radical Cyclizations: a One-Step Synthesis of Stereoisomeric Tricyclo[6.3.0.02,6]undecanes From Acyclic Precursors." Australian Journal of Chemistry 48, no. 2 (1995): 261. http://dx.doi.org/10.1071/ch9950261.

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Radical cyclization of (1E,5Z)-1-iodoundeca-1,5,10-triene with triphenyltin hydride provides one acyclic, one monocyclic, two bicyclic and four tricyclic products. At low concentration (0.002 M), the title tricycloundecane products resulting from triple cyclization predominate, but the stereoselectivity is low. Cyclization of (1E,5Z)-1-iodo-8,8-bis( phenylsulfonyl )undeca-1,5,10-triene followed by reductive desulfonylation provides a similar ratio of products to the parent. The results show that this class of triple cyclization occurs well, but the level of stereoselectivity must be raised for

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23

Barrionuevo, Cecilia A., Luciana C. Schmidt, and Juan E. Argüello. "Unexpected formation of 4,4-dimethyl-1,2-disubstituted-dicarbonyl cyclopentanes from ketone enolate anions and 1,3-diiodo-2,2-dimethylpropane." New Journal of Chemistry 40, no. 5 (2016): 4550–55. http://dx.doi.org/10.1039/c5nj03672k.

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24

Wang, Liang, Xuehu Li, Hua Tao, et al. "Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds." Organic & Biomolecular Chemistry 15, no. 11 (2017): 2403–10. http://dx.doi.org/10.1039/c6ob02802k.

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25

Zhu, Xiaoyan, Feng Liu, Xinwu Ba, and Yonggang Wu. "Tandem Suzuki Polymerization/Heck Cyclization Reaction to Form Ladder-Type 9,9′-Bifluorenylidene-Based Conjugated Polymer." Polymers 15, no. 16 (2023): 3360. http://dx.doi.org/10.3390/polym15163360.

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The synthesis of ladder-type 9,9′-bifluorenylidene-based conjugated polymer is reported. Unlike the typical synthetic strategy, the new designed ladder-type conjugated polymer is achieved via tandem Suzuki polymerization/Heck cyclization reaction in one-pot. In the preparation process, Suzuki polymerization reaction occurred first and then the intramolecular Heck cyclization followed smoothly under the same catalyst Pd(PPh3)4. The model reaction proved that the introduction of iodine (I) for this tandem reaction can effectively control the sequential bond-forming process and inhibit the additi

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26

Zheng, Dongsong, Qiankun Zhao, Xiaoying Hu, Tanyu Cheng, Guohua Liu, and Wei Wang. "A dynamic kinetic asymmetric transfer hydrogenation–cyclization tandem reaction: an easy access to chiral 3,4-dihydro-2H-pyran-carbonitriles." Chemical Communications 53, no. 45 (2017): 6113–16. http://dx.doi.org/10.1039/c7cc02156a.

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27

Grissom, Janet Wisniewski, Trevor L. Calkins, Dahai Huang, and Heidi McMillen. "High temperature radical cyclization anomalies in the tandem enediyne-bis-radical cyclization." Tetrahedron 50, no. 16 (1994): 4635–50. http://dx.doi.org/10.1016/s0040-4020(01)85004-3.

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28

Morikawa, Tsutomu, Tohru Nishiwaki, and Yoshiro Kobayashi. "Radical cyclization to the trifluoromethyl-substituted double bond: Regioselectivity and tandem cyclization." Tetrahedron Letters 30, no. 18 (1989): 2407–10. http://dx.doi.org/10.1016/s0040-4039(01)80412-3.

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29

Álvarez, Estela, Delia Miguel, Patricia García-García, Manuel A. Fernández-Rodríguez, Félix Rodríguez, and Roberto Sanz. "Solvent- and ligand-induced switch of selectivity in gold(I)-catalyzed tandem reactions of 3-propargylindoles." Beilstein Journal of Organic Chemistry 7 (June 9, 2011): 786–93. http://dx.doi.org/10.3762/bjoc.7.89.

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The selectivity of our previously described gold-catalyzed tandem reaction, 1,2-indole migration followed by aura-iso-Nazarov cyclization, of 3-propargylindoles bearing (hetero)aromatic substituents at both the propargylic and terminal positions, was reversed by the proper choice of the catalyst and the reaction conditions. Thus, 3-(inden-2-yl)indoles, derived from an aura-Nazarov cyclization (instead of an aura-iso-Nazarov cyclization), were obtained in moderate to good yields from a variety of 3-propargylindoles.

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30

Chen, Junjie, Xiuling Han, and Xiyan Lu. "Palladium(ii)-catalyzed tandem cyclization of 2-ethynylaniline tethered cinnamyl acetate for the synthesis of indenoindoles." Organic & Biomolecular Chemistry 18, no. 43 (2020): 8850–53. http://dx.doi.org/10.1039/d0ob01975e.

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31

Luo, Yanlong, Huaming Sun, Weiqiang Zhang, et al. "Triple zirconocene/brønsted acid/CuO cooperative and relay catalysis system for tandem Mannich addition/C–C formative cyclization/oxidation." RSC Advances 7, no. 46 (2017): 28616–25. http://dx.doi.org/10.1039/c7ra00870h.

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32

Zhang, Wen-Xiong, Ling Xu, and Zhenfeng Xi. "Recent development of synthetic preparation methods for guanidines via transition metal catalysis." Chemical Communications 51, no. 2 (2015): 254–65. http://dx.doi.org/10.1039/c4cc05291a.

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33

Giofrè, Salvatore V., Roberto Romeo, Raffaella Mancuso, et al. "A new microwave-assisted thionation-heterocyclization process leading to benzo[c]thiophene-1(3H)-thione and 1H-isothiochromene-1-thione derivatives." RSC Advances 6, no. 25 (2016): 20777–80. http://dx.doi.org/10.1039/c6ra01329e.

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34

Tyagi, Akshi, Noor U. Din Reshi, Prosenjit Daw, and Jitendra K. Bera. "Palladium complexes with an annellated mesoionic carbene (MIC) ligand: catalytic sequential Sonogashira coupling/cyclization reaction for one-pot synthesis of benzofuran, indole, isocoumarin and isoquinolone derivatives." Dalton Transactions 49, no. 43 (2020): 15238–48. http://dx.doi.org/10.1039/d0dt02918a.

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35

Yao, Hai-Feng, Dian-Liang Wang, Fang-Hui Li, Bing Wu, Zhong-Jian Cai, and Shun-Jun Ji. "Synthesis of organoselenyl isoquinolinium imides via iron(iii) chloride-mediated tandem cyclization/selenation of N′-(2-alkynylbenzylidene)hydrazides and diselenides." Organic & Biomolecular Chemistry 18, no. 38 (2020): 7577–84. http://dx.doi.org/10.1039/d0ob01517b.

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36

Gao, Yu-Qi, Yi Hou, Liming Zhu, et al. "Visible-light driven synthesis of polycyclic benzo[d][1,3]oxazocine from 2-aminochalcone." Chemical Communications 56, no. 49 (2020): 6739–42. http://dx.doi.org/10.1039/d0cc02416c.

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37

Zhao, Shangkun, Yuanyuan Zhu, Minli Zhang, Xixi Song, and Junbiao Chang. "Base-Mediated Tandem 1,6-Addition/Cyclization/Isomerization Reactions between para-Quinone Methides and Benzyl Chlorides: Approaches to Diverse Frameworks at Each Cascade Stage." Synthesis 51, no. 10 (2019): 2136–48. http://dx.doi.org/10.1055/s-0037-1610691.

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Base-mediated stereospecific tandem reactions using para-quinone methides and carbene-like benzyl chlorides are developed. DBU-mediated 1,6-addition/cyclization/isomerization reactions produce triarylsubstituted alkenes in 43–89% yields and Z/E ratios of 5:1 to 35:1 in favor of the Z-isomers. Single-step 1,6-conjugate additions are realized with the mediation of cesium carbonate, and different triaryl chloroethanes are obtained in yields of 41–54% and excellent diastereoselectivities of more than 20:1. In addition, tandem 1,6-addition/cyclization reactions are achieved using tuned 2,4-disubsti

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38

Yamamoto, Yasutomo, Tatsuya Yamaguchi, Atsunori Kaneshige, et al. "Consecutive Aminolithiation–Carbolithiation of a Linear Aminoalkene Bearing Terminal Vinyl Sulfide Moiety to Give Hydroindolizine." Synlett 28, no. 20 (2017): 2913–17. http://dx.doi.org/10.1055/s-0036-1588522.

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Aminolithiation–carbolithiation tandem cyclization of an aminoalkene bearing vinyl sulfide moiety proceeded smoothly using stoichiometric amounts of BuLi. Both aminolithiation and carbolithiation were in equilibrium at room temperature, and the stereochemistry of the cyclization was thermodynamically controlled. At –78 °C the reaction was kinetically controlled and the cyclized product, 1,2-disubstituted octahydroindolizine, was obtained with good diastereoselectivity.

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39

Gu, Zheng-Yang, and Ji-Bao Xia. "[3 + 1 + 1] cyclization of vinyl oxiranes with azides and CO by tandem palladium catalysis: efficient synthesis of oxazolidinones." Organic Chemistry Frontiers 8, no. 15 (2021): 4112–17. http://dx.doi.org/10.1039/d1qo00591j.

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40

Wang, Chaofan, Ling Fang, Lingling Zhang, Ya Wang, Fang Gao, and Zhiyong Wang. "Base-mediated unprecedented tandem cyclization reaction of nitrilimines and sulfur ylides: facile approaches to multifunctionalized pyrazolines." Organic Chemistry Frontiers 9, no. 8 (2022): 2204–8. http://dx.doi.org/10.1039/d2qo00232a.

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41

Jiang, Shuai-Shuai, Yu-Ting Xiao, Yan-Chen Wu, Shu-Zheng Luo, Ren-Jie Song, and Jin-Heng Li. "Manganese(iii)-promoted tandem phosphinoylation/cyclization of 2-arylindoles/2-arylbenzimidazoles with disubstituted phosphine oxides." Organic & Biomolecular Chemistry 18, no. 25 (2020): 4843–47. http://dx.doi.org/10.1039/d0ob00877j.

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42

Behera, Harekrushna, Venkatachalam Ramkumar, and Nandita Madhavan. "Triamide macrocyclic chloride receptors via a one-pot tandem reduction–condensation–cyclization reaction." Organic & Biomolecular Chemistry 15, no. 23 (2017): 4937–40. http://dx.doi.org/10.1039/c7ob00642j.

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43

Mou, Xue-Qing, Zheng-Liang Xu, Shao-Hua Wang, et al. "An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole." Chemical Communications 51, no. 60 (2015): 12064–67. http://dx.doi.org/10.1039/c5cc03979g.

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44

Li, Yonghong, Yuanyuan Zhu, and Shang-Dong Yang. "Visible-light-induced tandem phosphorylation cyclization of vinyl azides under mild conditions." Organic Chemistry Frontiers 5, no. 5 (2018): 822–26. http://dx.doi.org/10.1039/c7qo01004d.

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45

Kiamehr, Mostafa, Firouz Matloubi Moghaddam, Satenik Mkrtchyan, et al. "Tandem dinucleophilic cyclization of cyclohexane-1,3-diones with pyridinium salts." Beilstein Journal of Organic Chemistry 9 (June 10, 2013): 1119–26. http://dx.doi.org/10.3762/bjoc.9.124.

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The cyclization of cyclohexane-1,3-diones with various substituted pyridinium salts afforded functionalized 8-oxa-10-aza-tricyclo[7.3.1.02,7]trideca-2(7),11-dienes. The reaction proceeds by regioselective attack of the central carbon atom of the 1,3-dicarbonyl unit to 4-position of the pyridinium salt and subsequent cyclization by base-assisted proton migration and nucleophilic addition of the oxygen atom to the 2-position, as was elucidated by DFT computations. Fairly extensive screening of bases and additives revealed that the presence of potassium cations is essential for formation of the p

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46

Fan, Jian, Shengke Wang, Jiahui Chen, Manyi Wu, Jitan Zhang, and Meihua Xie. "Synthesis of 2-acetyl trisubstituted furans via copper-mediated deacylation cleavage of unstrained C(sp3)–C(sp2) bonds." Organic Chemistry Frontiers 6, no. 4 (2019): 437–41. http://dx.doi.org/10.1039/c8qo01139g.

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47

Mahapatra, Ajit Kumar, Kalipada Maiti, Saikat Kumar Manna, et al. "A cyclization-induced emission enhancement (CIEE)-based ratiometric fluorogenic and chromogenic probe for the facile detection of a nerve agent simulant DCP." Chemical Communications 51, no. 47 (2015): 9729–32. http://dx.doi.org/10.1039/c5cc02991k.

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48

Padwa, A. "Tandem methodology for heterocyclic synthesis." Pure and Applied Chemistry 76, no. 11 (2004): 1933–52. http://dx.doi.org/10.1351/pac200476111933.

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Tandem methodology for heterocyclic synthesis represents a powerful approach for the rapid buildup of molecular complexity from potentially simple starting materials. Work from our laboratory has shown that the rhodium(II)-catalyzed cyclization cascade of alpha-diazo imides represents an effective method for the synthesis of a variety of heterocyclic systems. As an extension of these studies, we became interested in using a linked Pummerer/N-acyliminium ion cyclization sequence since we felt that this combination offers unique opportunities for the assemblage of complex target molecules. A syn

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49

Peng, Haiyun, Yinbo Wan, Yu Zhang, and Guisheng Deng. "Synthesis of 2-alkenylfurans via a Ag(i)-catalyzed tandem cyclization/cross-coupling reaction of enynones with iodonium ylides." Chemical Communications 56, no. 9 (2020): 1417–20. http://dx.doi.org/10.1039/c9cc08561k.

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50

Mai, Wen-Peng, Fei Wang, Xiao-Feng Zhang, Shi-Min Wang, Qun-Peng Duan та Kui Lu. "Nickel-catalysed radical tandem cyclisation/arylation: practical synthesis of 4-benzyl-3,3-difluoro-γ-lactams". Organic & Biomolecular Chemistry 16, № 35 (2018): 6491–98. http://dx.doi.org/10.1039/c8ob01389f.

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