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Dissertations / Theses on the topic 'Therapeutic Responses Against Diseases'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Phalane, Khutso Gemina. "Evaluation of multiple cytokine levels to improve our understanding of protective immune responses against Tuberculosis and to develop novel diagnostic methods." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79848.

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Thesis (MScMedSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Important steps towards the global control of Tuberculosis include the improvement of diagnosis, the development of effective vaccines and the identification of correlates of protection/protective immunity to Mycobacterium tuberculosis. This study has of three objectives: 1. To validate the findings of a previous study that showed increased levels of IL-1β and decreased levels of IL-17 in children who are exposed to tuberculosis but remain uninfected compared to those who are exposed/infected and unexposed/uninfected. 2.

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2

Li, Yihang Kaltenboeck Bernhard. "Therapeutic vaccines against chlamydial diseases." Auburn, Ala., 2008. http://hdl.handle.net/10415/1417.

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3

Barakat, Farah Mukhlis. "Protective innate immune responses against Cryptosporidium parvum." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8733.

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Cryptosporidiosis is a common infectious diarrhoeal disease of mammalian livestock and humans worldwide. The etiological organisms responsible are intestinal apicomplexans of the genus Cryptosporidium, including C. parvum, that infect intestinal epithelial cells. Immunocompromised or malnourished hosts develop severe life-threatening disease. Immunological elimination of Cryptosporidium requires CD4+ T cells and IFN-γ. Nevertheless, studies have shown innate immune responses have a significant protective role. Importantly, in T cell-deficient mice, IFN-γ is important for control of C. parvum i

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Yenilmez, Batuhan O. "DEVELOPMENT OF AN RNAi THERAPEUTIC STRATEGY AGAINST NON-ALCOHOLIC STEATOHEPATITIS (NASH)." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1158.

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Nonalcoholic steatohepatitis (NASH) is a severe liver disorder characterized by triglyceride accumulation, severe inflammation, and fibrosis. With the recent increase in prevalence, NASH is now the leading cause of liver transplantation, with no approved therapeutics available. Despite years of research, the exact molecular mechanism of NASH progression is not well understood, but fat accumulation is believed to be the primary driver of the disease. Therefore, diacylglycerol O-acyltransferase 2 (DGAT2), a key enzyme in triglyceride synthesis, has been explored as a NASH target. RNAi-based ther

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5

Antrobus, Richard. "Characterising immune responses to viral vectored vaccines against influenza and hepatitis C." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a3efad5e-d619-4641-8c05-2d4e336a10dc.

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For both influenza viruses and hepatitis C viruses, T cell responses to conserved antigens are one strategy for the human host to control the spread of infection. Such T cell responses can be generated with the use of viral vectored vaccines. Initially I show that the viral vectored vaccine MVA-NP+M1 can boost memory T cell responses to influenza A virus in adults aged over 50 years old. However within this group, MVA-NP+M1 had reduced immunogenicity in adults who were aged over 70 years old. The influenza virus-specific T cell responses comprised both CD4 and CD8 T cells, and were capable of

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6

Ye, Xingshen, and 叶星沈. "Studies on effects of coptis extract and berberine against carbon tetrachloride-induced liver damage in rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38755208.

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7

Jayatunga, Dona Pamoda Wajirapanie. "Investigation of selected nutraceuticals to protect against mitochondrial dysfunction: Potential therapeutic role in Alzheimer’s disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2020. https://ro.ecu.edu.au/theses/2368.

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Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that affects approximately 60-80% of all clinically diagnosed dementia cases worldwide. It is the second major cause of death in Australia. The progressive nature of the disease is characterized by cognitive deficits that worsen over time, usually leading to death within about a decade from their first manifestation. The AD brain is classically characterized by extracellular deposition of amyloid-β (Aβ) protein aggregates, as senile plaques, and intracellular neurofibrillary tangles (NFTs), composed of hyper-phosphorylated fo

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8

Xie, Lixia. "Effects of salvianolic acid B against apoptosis and adhesion molecules expression in the vascular endothelial cells." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1082.

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9

Kelly, Christabel. "Novel adenoviral vectored vaccines and the implications of viral diversity in therapeutic strategies against Hepatitis C Virus infection." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:8991c349-7096-4643-ae6a-2e36902c8056.

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Hepatitis C virus (HCV) is a major global pathogen estimated to infect over 170 million people worldwide. A recent study has shown that vaccination with adenoviral vectors, based on rare human and simian serotypes encoding the non-structural (NS) proteins of HCV, induces highly potent, multi-specific and durable T cell responses in healthy human volunteers. In this thesis I assess the safety and immunogenicity of these vaccines (ChAd3–NSmut and Ad6-NSmut), for the first time in HCV infected patients. This work also explores whether vaccine-induced T cell responses target in vivo circulating HC

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10

Zuber, Chantal. "Antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools for the treatment of prion diseases and cancer." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-88001.

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11

VALLONE, ALESSANDRA. "INVESTIGATION OF NOVEL THERAPEUTIC TOOLS AGAINST INFECTIOUS DISEASES Part 1. Medicinal Chemistry Investigation of MMV019918 Derivatives as Dual Schizonticide And Gametocytocidal Agents Against Plasmodium falciparum Part 2. Investigation of 5-Aryl-Heterocycles As Potential Inhibitors of Metallo beta-Lactamase Enzymes." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1004943.

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Among infectious diseases, two large groups have great clinical relevance: parasitic and bacterial infections. Belonging to the first category is malaria, caused by the parasite Plasmodium falciparum. Transmission of Plasmodium parasites between humans and Anopheles mosquitoes is one of the most important contributors to the global impact of malaria and to the difficulties encountered in eliminating this parasite1 . Gametocytogenesis, the process by which merozoites switch from asexual replication to produce male and female gametocytes, represents a critical step in malaria transmission

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12

Chassagnol, Bastien. "Application of Multivariate Gaussian Convolution and Mixture Models for Identifying Key Biomarkers Underlying Variability in Transcriptomic Profiles and the Diversity of Therapeutic Responses." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS512.pdf.

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La diversité des phénotypes et des conditions observées au sein de l'espèce humaine est le résultat de multiples processus biologiques interdépendants. Cependant, dans le contexte de la médecine personnalisée et du traitement de maladies de plus en plus complexes, systématiques et hétérogènes, il est crucial de développer des approches qui capturent de manière exhaustive la complexité des mécanismes biologiques sous-jacents à la variabilité des profils biologiques. Cela s'étend du niveau individuel au niveau cellulaire, englobant les tissus et les organes. Une telle précision et une telle gran

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13

Baloche, Valentin. "Contributions négatives et positives de la galectine-9 au développement tumoral : étude dans des modèles tumoraux murins syngéniques In the MB49 Murine Model, Genetic Ablation of Galectin-9 Enhances Anti-Tumor Immune Response: Possible Role of a Greater CXCL9/Il-6 Production Tumor Exosomal Micrornas Thwarting Anti-Tumor Immune Responses in Nasopharyngeal Carcinomas Interferon β and Anti-PD1/PD-L1 Checkpoint Blockade Cooperate in NK Cell-Mediated Killing of Nasopharyngeal Carcinoma Cells Interferon Beta Increases NK Cell Cytotoxicity against Tumor Cells in Patients with Nasopharyngeal Carcinoma via Tumor Necrosis Factor Apoptosis-Inducing Ligand Emerging Therapeutic Targets for Nasopharyngeal Carcinoma: Opportunities and Challenges Galectin-9 Promotes a Suppressive Microenvironment in Human Cancer by Enhancing STING Degradation". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS117.

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Comme les autres galectines, la galectine-9(gal-9) est une lectine animale qui interagit avec un sous-groupe défini de polysaccharides portés par des glycoprotéines ou des glycolipides. La gal-9 associée aux cellules exerce de multiples fonctions dans le cytoplasme, dans le noyau et à la surface de la membrane plasmique. Quelques publications suggèrent que la gal-9 intra-cellulaire inhibe la mobilité des cellules malignes et exerce un effet antimétastatique. En outre la gal-9 peut être sécrétée dans le milieu extra-cellulaire où elle se comporte comme une cytokine avec des effets principalemen

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14

"Therapeutic vaccines against chlamydial diseases." AUBURN UNIVERSITY, 2009. http://pqdtopen.proquest.com/#viewpdf?dispub=3348250.

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15

Shao, Zixuan. "Biological Responses to Therapeutic Treatments of Human Vascular Diseases." Thesis, 2019. https://thesis.library.caltech.edu/11570/37/20190607_Shao_Zixuan_2019_thesis.pdf.

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<p>Diseases of the retina affect hundreds of millions of patients worldwide, with limited treatment options available. ALG-1001 is an investigational drug that showed success in mitigating disease symptoms in animal models and improved patient vision in multiple clinical trials. To gain a better understanding of the drug’s mechanism of action, RNA sequencing (RNA-seq) and shotgun proteomics were employed to study the drug-induced transcriptome change in retinal tissue and cell culture models. Chapter 2 focuses on application of this approach in an animal model of the disease that showed the dr

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16

"Effects of thrombopoietin on the protection against doxorubicin-induced cardiotoxicity." 2006. http://library.cuhk.edu.hk/record=b5893012.

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To Man Yin.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (leaves 85-105).<br>Abstracts in English and Chinese.<br>Abstract (in English) --- p.i<br>(in Chinese) --- p.iv<br>Acknowledgements --- p.vi<br>Publications --- p.viii<br>Table of Contents --- p.ix<br>List of Tables --- p.xii<br>List of Figures --- p.xiii<br>List of Abbreviations --- p.xiv<br>Chapter CHAPTER 1: --- General Introduction --- p.1<br>Chapter Section 1.1 --- Background and Clinical Application of Anthracylines --- p.1<br>Chapter Section 1.2 --- DOX-induced Cardio

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17

"Hepatoprotection of the traditional Chinese medicinal formula Wu-zi-yan-zong-wan against chronic alcohol-induced injury." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074567.

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Finally, the hepatoprotection of the 50%EtWZ was evaluated using rat model. The results indicated that the 50%EtWZ possessed potent hepatoprotective activities. The protective effect of the extract against hepatotoxicity induced by long-term treatment with ethanol might be attributed to its inhibitory action on oxidative stress. Although multiple factors could be involved in the inhibition of oxidative injury in the liver, the inhibition of CYP2E1 pathway and the enhanced GSH-related antioxidant capacity might be responsible for the protective effect. In addition, the 50%EtWZ also produced ant

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18

Pratt, Mary Margaret. "Chlorophyllin chemoprevention against Dibenzo[a,l]pyrene-initiated multi-organ carcinogenesis in the rainbow trout model." Thesis, 2003. http://hdl.handle.net/1957/31143.

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Chlorophyllin (CHL), a water-soluble derivative of the green plant pigment, chlorophyll, is an effective antimutagen and anticarcinogen in various model systems when used as a modulator against a class of carcinogens that, in general, have a structure consisting of at least three fused rings. Dibenzo[a,l]pyrene (DBP), an extremely potent environmental carcinogen, has been isolated from urban air samples, tobacco smoke, and coal smoke condensate. A study was conducted to evaluate the complex interrelationships among dietary DBP doses with co-exposure to a range of CHL doses. In order to achieve

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19

Zuber, Chantal [Verfasser]. "Antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools for the treatment of prion diseases and cancer / Chantal Zuber." 2008. http://d-nb.info/989934071/34.

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20

"Protective effects of seaweeds against liver injury caused by carbon tetrachloride and trichloroethylene in rats." 2000. http://library.cuhk.edu.hk/record=b5890528.

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Wong Chun-kwan.<br>Thesis submitted in: December 1999.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2000.<br>Includes bibliographical references (leaves 127-137).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Acknowledgments --- p.viii<br>Tables of Contents --- p.ix<br>List of Figures --- p.xv<br>List of Tables --- p.xxvi<br>Chapter Chapter 1: --- INTRODUCTION --- p.1<br>Chapter Chapter 2: --- LITERATURE REVIEW --- p.8<br>Chapter 2.1 --- Toxicology --- p.8<br>Chapter 2.1.1 --- Acute toxicity test --- p.8<br>Chapter 2.1.2 --- Biochemical Analysis --- p.9<br>Chap

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21

"Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and mitochondrial dysfunction." Thesis, 2010. http://library.cuhk.edu.hk/record=b6075047.

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Additionally, cyclosporin A, an inhibitor of the mitochondrial permeability transition (MPT) pore, failed to prevent hIAPP-induced DeltaPsim collapse, cytochrome c and AIF release and caspase-3 activation, indicating that the MPT pore was not involved in hIAPP-induced apoptosis. On the other hand, potential crosstalk between the extrinsic and intrinsic apoptotic pathways was demonstrated by cleavage of Bid by caspase-8 in the apoptotic process triggered by hIAPP.<br>It is widely accepted that human islet amyloid polypeptide (hIAPP) aggregation plays an important role in the loss of insulin-pro

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