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Dissertations / Theses on the topic 'Thioester synthesis'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Le, Sann Christine. "Enantioselective synthesis of N-Acetylcysteamine thioester putative intermediates to polyketides." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340274.

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2

Torkko, J. (Juha). "Characterization of mitochondrial 2-enoyl thioester reductase involved in respiratory competence." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514270312.

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Abstract Maintenance of the mitochondrial respiratory chain complexes plays crucial role for the aerobic metabolism of the eukaryotes such as unicellular yeasts, for example, Saccharomyces cerevisiae as well as of human being. Mitochondrial respiratory function has been studied using the yeast S. cerevisiae as a model organism. Since yeast cells are also able to grow without respiration by fermentation, identification of the nuclear genes linked to respiratory function is possible by generation of nuclear gene deletions and testing for respiration-deficient phenotype of the yeast deletion str

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3

Miinalainen, I. (Ilkka). "Enoyl thioester reductases—enzymes of fatty acid synthesis and degradation in mitochondria." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514282442.

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Abstract Fatty acids are one of the most essential categories of biological lipids and their synthesis and degradation are vital for all organisms. Severely compromised phenotypes of yeast mutants and human patients, which have defective components in their degradative or synthetic processes for fatty acid metabolism, have highlighted the importance of these processes for overall metabolism. Most fatty acids are degraded by β-oxidation, which occurs in mitochondria and peroxisomes in mammals, whereas synthesis is catalyzed by cytosolic multifunctional peptides, although a synthesis system invo

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4

Soares-Sello, Anna Mampe. "Biosynthetic studies of strobilurins." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389145.

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5

Brandes, Dee Anne. "The synthesis and reactivity of alpha,beta-unsaturated thioamide, thioester, and thione iron tricarbonyl complexes." Thesis, University of Ottawa (Canada), 1990. http://hdl.handle.net/10393/6008.

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$\alpha,\beta$-Unsaturated thioamide, thioester and thione iron tricarbonyl complexes 1-13 were prepared from the free ligands and iron pentacarbonyl using photolysis or diiron nonacarbonyl using thermolysis. X-ray crystal structures were obtained for the free ligand 2$\sp\prime,$ (PhCH=C(Ph)C(S)NEt$\sb2$), and for complexes 1 and 2, $\rm\lbrack \overline{\overline{Fe(PhCH}{=}CHC(S})NEt\sb2)$(CO)$\sb3\rbrack$ and $\rm\lbrack \overline{\overline{Fe(PhCH}{=}C(Ph)C(S})NEt\sb2)$(CO)$\sb3\rbrack$ respectively. Thioamide and thioester iron tricarbonyl complexes gave triphenylphosphine substituted co

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6

Chen, Z. (Zhijun). "Characterization of the 2-enoyl thioester reductase of mitochondrial fatty acid synthesis type II in mammals." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514289804.

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Abstract A data base search using the amino acid sequence of Saccharomyces cerevisiae Etr1p, the last enzyme of mitochondrial fatty acid synthesis type II (FAS II), revealed a highly similar human protein, NRBF-1. Expression of NRBF-1 in a yeast etr1Δ strain rescued its respiratory deficiency. NRBF-1 resides in mitochondria in cultured HeLa cells. The recombinant NRBF-1 is enzymatically active, reducing 2E-enoyl-CoAs to acyl-CoAs in an NADPH-dependent manner. Altogether, our data showed that NRBF-1 is a mitochondrial 2-enoyl-CoA reductase/2-enoyl thioester reductase (MECR/ETR1), the human fun

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7

Sutherland, Ian Thor. "APPLYING A LATE-STAGE LAWESSON’S CYCLIZATION STRATEGY TOWARDS THE SYNTHESIS OF 1,3,4-THIADIAZOLE-2-CARBOXYLATE THIOESTERS." Kent State University Honors College / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1437100137.

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8

Henze, Rüdiger. "Tautomérisation énantiosélective d'un énol." Rouen, 1997. http://www.theses.fr/1997ROUES020.

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La réaction de l'aldéhyde 2-benzylacrylique avec des acides thiocarboxyliques donne accès à de nouveaux énols métastables. Leur conformation a été étudiée en utilisant des calculs semi-empiriques et des méthodes spectroscopiques. Des calculs AM1 ont révélé que la conformation préférée du Z-éthanethioate de 2-benzyl-3-hydroxy-2-propényle en absence de solvants fait intervenir une interaction intramoléculaire entre les groupements hydroxyle et carbonyle du thioester. Une étude par IR et par RMN a montré que la conformation du Z-1-benzènecarbothioate de 2-benzyl-3-hydroxy-2-propényle était dépend

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9

Turkarslan, Ozlem. "Synthesis, Characterization And Electrochromic Properties Of Conducting Copolymers Of Terephthalic Acid Bis-(thiophen-3-ylmethyl)thioester With Thiophene And Pyrrole And Conducting Polymer Of 1-(4-fluorophenyl)-2,5-di(thiophen-2-yl)-1h-pyrrole." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607169/index.pdf.

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Terephthalic acid bis-(thiophen-3-ylmethyl)thioester (TTMT) was synthesized via the reaction of thiophen-3-ylmethanethiol with terephthaloyl dichloride. Nuclear magnetic resonance (1H-NMR) and Fourier transform infrared (FTIR) spectroscopies were utilized for the characterization of the monomer. This 3-functionalized thiophene monomer was polymerized in the presence of thiophene (Th) and pyrrole (Py) upon constant potential application in acetonitrile/tetrabutylammonium tetrafluoroborate (TBAFB). The resulting copolymers were characterized via cyclic voltammetry (CV), FTIR, differential scanni

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10

Shah, Syed Tasadaque Ali. "Regio- und stereoselektive Synthesen von chiralen heterozyklischen Kohlenhydratkonjugaten Cäsiumfluorid-Celit: eine feste Base für die Synthese von Estern, Ethern, Thioestern, Thioethern und symmetrischen Disulfiden /." [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10733078.

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11

Byeon, Chang-Ho. "Part I. Reactions of alpha,beta-unsaturated thioesters and selenoesters with enamines :Part II. Alpha,beta-unsaturated thioesters and selenoesters as dienophiles :Synthesis of cyclohexene derivatives /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487856076418125.

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12

Kang, J. "Native chemical thioesterification : synthesis of peptide and protein thioesters through an N→S acyl shift." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1150770/.

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The total chemical synthesis of a protein provides atomic-level control over its covalent structure, however polypeptides prepared by solid phase peptide synthesis are limited to approximately fifty amino acid residues. This limitation has been overcome by 'Native Chemical Ligation‘, which involves amide bond formation between two unprotected polypeptides: a peptide with a C-terminal thioester and an N-terminal cysteinyl peptide. Synthesis of the required peptide thioester is difficult, particularly by Fmoc-chemistry. During our studies towards the semisynthesis of erythropoietin, we discovere

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13

Ali, Shah Syed Tasadaque. "Regio- and stereoselective syntheses of chiral heterocyclic carbohydrate conjugates cesium fluoride-celite ; a solid base for syntheses of esters, ethers, thioesters, thioethers and symmetrical disulfides = Regio- und stereoselektive Synthesen von chiralen heterozyklischen Kohlenhydratkonjugaten /." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968539092.

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14

Raz, Richard [Verfasser]. "Development of a tert-butyl thiol linker for the synthesis of peptide thioesters and thioacids for application in chemical ligation methods / Richard Raz." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025939719/34.

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15

Hui, Mario Lee Tsung. "Estudo conformacional e das interações eletrônicas dos a-(etilsulfonil)-tioacetatos de fenila-para-substituídos." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-22082018-110102/.

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A presente Dissertação relata o estudo conformacional e das interações eletrônicas dos α-(etilsulfonil)-tioacetatos de fenila-para-substituídos X-Φ-S-C(O)-CH2-SO2-Et, sendo X substituintes atraentes, hidrogênio e doadores de elétrons, isto é, X= NO2 (1), Cl (2), Br (3), H (4), Me (5) e OMe (6) através da espectroscopia no Infravermelho, apoiada por cálculos ab initio e difração de Raio-X. Os dados obtidos indicaram a existência dos confôrmeros gauche1(s-trans) e um gauche2(s-cis), sendo este último bem mais estável do que o primeiro. Assim sendo, pode-se concluir que o componente de

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16

Donnici, Claudio Luis. "Caminhos sintéticos para obtenção de ésteres e tioésteres - α-metilsulfonil-α-metiltio-substituídos, precursores dos derivados α-ceto-carbocxílicos correspondentes." Universidade de São Paulo, 1993. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-23062015-131015/.

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Este trabalho apresenta: 1) Duas revisões bibliográficas sendo uma sobre a síntese de α-ceto-tioésteres e -ésteres e a outra sobre a decomposição de sulfóxidos e sulfonas sulfeniladas; 2) Investigações prévias indicando a viabilidade da decomposição térmica e a estabilidade relativa dos derivados bissulfenilados de tioésteres de diferentes estados de oxidação Ia-e, obtidos a partir do α-ceto-tioéster; 3) O estudo de síntese de precursores de α-ceto-tioésteres II e α-ceto-ésteres III, a saber: α - metilsulfonil- α - metiltio tioésteres IVa-c, -éster V e α, &

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17

Chen, Kuan-Ting, and 陳冠廷. "Synthesis and Properties of Thioester Liquid Crystals Derived from (S) - Lactic Acid." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/27955632798043594440.

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碩士<br>大同大學<br>化學工程學系(所)<br>93<br>The primary research was an attempt to study the correlation between structure and property in the chiral liquid crystal materials. Three homologous series of chiral materials derived from (S)-lactic acid were successfully synthesized and investigated the relationship between molecular structures and the mesomorphic properties relationship. The target compounds were modified independently by (i) the length of achiral aliphatic chain ’m’ (ii) the lateral substitution group in the core and (ii) the structure of chiral aliphatic chain. The results show that chiral

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18

Chou, Ming-Chen, and 周銘城. "Synthesis of a,b-butenolide from r-oxo-a,b-unsaturat thioester." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/74568066189271645873.

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碩士<br>國立交通大學<br>應用化學系<br>83<br>Reaction of cis-r-oxo-a,b-unsaturated thioesters with sodiumdride, Grignard reagents, and allylsilanes at low temperature gave the r-substituted-a,b-butenolides. On the other hand, Reaction of the trans-r-oxo-a,b-unsaturated thioesters with sodium borohydride, Grignard reagents, and allylsilanes at low temperature gave the a,b-unsaturated thioesters. Reaction of the cis-r-oxo-a,b-unsaturated thioesters with silica gel gave the r-alkylidene-a,b-

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19

Sauer, Scott J. "Direct Carbon--Carbon Bond Formation Through Reductive Soft-Enolization of α-Halothioesters and The Total Synthesis of (+)-Mefloquine." Diss., 2011. http://hdl.handle.net/10161/3952.

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<p>The direct addition of enolizable aldehydes and sulfonyl imines to α-halo thioesters to produce β-hydroxy/amino thioesters enabled by reductive soft enolization is reported. The transformation is operationally simple and efficient and has the unusual feature of giving high <italic>syn</italic>-selectivity, which is the opposite of that produced for the aldol addition with (thio)esters under conventional conditions. This method is tolerant to aldehydes and imines that not only contain acidic α-protons, but also towards electrophiles containing other acidic protons and base-s

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20

Kohler, Mark Christopher. "Part I: The Development of the Organocatalytic Asymmetric Mannich and Sulfenylation Reactions Part II: Progress Towards the Synthesis of Lagunamide A." Diss., 2012. http://hdl.handle.net/10161/5546.

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<p>This dissertation deals with the development of asymmetric carbon-carbon and carbon-heteroatom bond-forming reactions and the synthesis of Lagunamide A. Asymmetric C-C and C-X bond formations are critical transformations in synthetic chemistry. While a variety of approaches are available to effect such reactions, organocatalytic methods have attracted considerable recent attention. Common themes have emerged from these studies with regard to both the mode of asymmetric catalysis and the nature of the substrates they are applied to. We have been investigating alternatives to these themes

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21

Garnsey, Michelle Renee. "Direct Carbon-Carbon Bond Formation via Base Mediated and Reductive Soft Enolization of Thioesters, the First Asymmetric Total Synthesis of (+)- and (-)-Clusianone, and Progress Toward the Asymmetric Total Synthesis of Brasilicardin A." Diss., 2012. http://hdl.handle.net/10161/5573.

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<p>Three methodology studies and two total synthesis endeavors are presented. First, a study of Lewis acid and hydrogen bond mediated soft enolization of thioesters and their addition to imines in the Mannich reaction is reported. MgBr2*OEt2 and Hunig's base are used in concert with bulky thioesters and aromatic aldehydes to generate syn-b-aminothioesters with moderate diastereoselectivity and yield. Next, a biomimetic organocatalytic Mannich reaction is presented using a chiral cinchona alkaloid to effect the enantioselective addition of an imines to thioesters with high yield and diastere

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22

Tasi, Shin-Hwa, та 蔡世華. "Study on the Medium Effect to the Diels-Alder Reaction of γ-Oxo-α,β-Unsaturatewd Thioester with Cyclopentadiene. Synthesis of Oxa-Cages which Contain Two and Three Oxygen Atoms on the Skeleton". Thesis, 1996. http://ndltd.ncl.edu.tw/handle/21963427799440180877.

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博士<br>國立交通大學<br>應用化學研究所<br>84<br>Diels-Alder reaction of the cis-isomer 2b with cyclopentadiene in various media are investigated. In β-CD aqueous solution, the endo/exo ratio can be increased up to 99:1. Diels-Alder reaction of the trans-isomer 3 with cyclopentadiene gave the cycloadducts 6 and 7, which stereochemistry was confirmed by chemical transformations such as reaction and iodocyclization reaction. Iodocyclization of 7b and 7c gave the methylthio group rearranged products 25b and 25c, which structure was proven by X-ray analysis of the crystalline compound 25b. Diels-Alder re

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23

(8086712), Lee M. Stunkard. "UNVEILING ENZYMATIC MECHANISMS WITH MALONYL-THIOESTER ISOSTERES." Thesis, 2019.

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Malonyl-thioesters are reactive at the thioester carbonyl and the carboxylate moieties, as seen in acyl transfer or hydrolysis and decarboxylation. Enzymes use these reactive centers to perform different enzyme chemistry throughout metabolism. This enzyme chemistry coupled with the inherent reactivity of malonyl-thioesters makes structure-function studies difficult. When malonyl-thioesters are used for structure-function studies, it usually results in a hydrolyzed or decarboxylated product. There are examples, however, where this is overcome, many of which are discussed throughout this thesis.

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24

Gopinath, P. "Synthesis Of Novel Chalcogenides Using Acyloxyphosphonium Intermediates And Doubly Activated Cyclopropanes." Thesis, 2010. http://etd.iisc.ernet.in/handle/2005/2157.

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The thesis entitled "Synthesis of Novel Chalcogenides using Acyloxyphosphonium Intermediates and Doubly Activated Cyclopropanes" is divided into six chapters. Chapter 1: Part 1: Synthesis of thioesters from carboxylic acids and alkyl halides using benzyltriethylammonium tetrathiomolybdate In this chapter, we describe the synthesis of thioesters from carboxylic acids and alkyl halides. Aryl carboxylic acids are first activated using PPh3 and NBS to form the corresponding acyloxy phosphonium intermediates which then on further reaction with reagent, 1generate thioaroylate ions in situ. These t

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25

Liao, Yen-Sen, and 廖彥森. "(1)One-pot Synthesis of Thioesters with Bunte Salts as a Sulfur Surrogate under Transition Metal-Free Conditions(2)Hexamethyldisilazane Promoted C-N Bond Formation via Thioesters: Synthesis of Benzamides and Dimethylformamidines." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/2am6n9.

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碩士<br>國立中興大學<br>化學系所<br>106<br>In the first part of this thesis, we reported a convenient method of one-pot synthesis of thioesters by using odorless sodium thiosulfate, various anhydrides and organic halides. Compared with traditional method, this method did not use thiols, which possessed malodorous flavors and easily oxidized to form the disulfide bond. This synthetic method was firstly using organic anhydrides and sodium thiosulfate to form the Bunte salts, followed by reacting with organic halides to generate thioesters. Furthermore, two important organic compounds could be successfully s

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26

Lu, Shao-Yi, and 呂紹億. "1.DTBP-Promoted Synthesis of Thioesters from Aldehydes and Thiols 2. Copper-Catalyzed Amide Synthesis from Aldehydes and Amines in Water." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/98786438704365345273.

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碩士<br>國立中興大學<br>化學系所<br>103<br>First part of this thesis discusses the formation of C-S bond in the presence of DTBP as an oxidant under metal-free and solvent-free conditions. This system shows good functional group compatibility with electron donating and electron withdrawing groups. Halo-groups are also well tolerated under reaction conditions employed. The heterocyclic starting materials also utilized for this reaction system. Second part of this thesis describes the copper-catalyzed direct oxidative cross-coupling of aldehydes with amines to afford amides in the presence of TBHP as an oxi

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27

Saravanan, V. "Chemistry Of Thio And Seleno Metallates In Organic Synthesis." Thesis, 2004. http://hdl.handle.net/2005/336.

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Thio metallates are known for many years for their utility in many processes. They have been established as versatile reagents in organic synthesis. However the heavier metal chalcogenides, though known for many years, have been ignored for a long time. In this thesis the results of the development of tetraethylammonium tetraselenotungstate [EttN]2Wse4 1 as a new class of selenium transfer reagent have been described. The thesis also deals with the chemistry of benzyltriethylammonium tetrathiomolybdate, [BnEt3N]2MoS4,2 in the synthesis of diselenides and thio esters. The thesis entitled "Chemi

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28

Tarsis, Emily Michelle. "New Methods for the α-Functionalization of Thioesters and Activated Hydrazones and an Application Toward the Total Synthesis of Apratoxin D." Diss., 2010. http://hdl.handle.net/10161/3074.

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<p>Cascade reactions, also referred to as domino reactions, have been widely used for the formation of carbon-carbon bonds. This type of reaction has the potential to circumvent protection and deprotection steps, shortening an overall synthetic process.</p><p>The Morita-Baylis-Hillman (MBH) reaction is a particularly notable example of an anionic domino reaction which provides straightforward access to β'-hydroxy-α,β-unsaturated carbonyl compounds from aldehydes and α,β-unsaturated carbonyls. However, despite the importance of the Baylis-Hillman reaction, it is slow, r

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29

Ali, Shah Syed Tasadaque [Verfasser]. "Regio- and stereoselective syntheses of chiral heterocyclic carbohydrate conjugates : cesium fluoride-celite ; a solid base for syntheses of esters, ethers, thioesters, thioethers and symmetrical disulfides = Regio- und stereoselektive Synthesen von chiralen heterozyklischen Kohlenhydratkonjugaten / vorgelegt von Syed Tasadaque Ali Shah." 2003. http://d-nb.info/968539092/34.

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30

Hsieh, Ping An, and 謝秉桉. "1. Syntheses of Selenide Ethers and Thioesters from Methyl Arenes Through sp³ C-H Functionalization2. Peracetic Acid-Mediated sp² C-H Selenation of Methyl Arenes." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/3bg959.

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碩士<br>國立中興大學<br>化學系所<br>103<br>In the first part of this thesis, A DTBP-promoted, operationally simple, metal-free and solvent-free C-Se and C-S bond formation through a sp³ C-H functionalization of methyl arenes with diselenides and disulfides is described. Diselenides and disulfides containing various functionalities were coupled smoothly with a broad spectrum of methyl arenes, afforded the corresponding selenide ethers and thioesters in moderate to good yields. This system shows good functional group tolerance, functional groups including chloro, bromo, trifluoromethyl and iodo were tolerat

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