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Journal articles on the topic 'Thiohydantoins'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Shybanov, Dmitry E., Maxim E. Kukushkin, Yanislav S. Hrytseniuk, et al. "[4+2]-Cycloaddition to 5-Methylidene-Hydantoins and 5-Methylidene-2-Thiohydantoins in the Synthesis of Spiro-2-Chalcogenimidazolones." International Journal of Molecular Sciences 24, no. 5 (2023): 5037. http://dx.doi.org/10.3390/ijms24055037.

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Novel hydantion and thiohydantoin-based spiro-compounds were prepared via theDiels–Alder reactions between 5-methylidene-hydantoins or 5-methylidene-2-thiohydantoins and 1,3-dienes (cyclopentadiene, cyclohexadiene, 2,3-dimethylbutadiene, isoprene). It was shown that the cycloaddition reactions proceed regioselectively and stereoselectively with the formation of exo-isomers in the reactions with cyclic dienes andthe less sterically hindered products in the reactions with isoprene. Reactions of methylideneimidazolones with cyclopentadiene proceed viaco-heating the reactants; reactions with cyclo

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2

Allegretti, Patricia E., M. de las Mercedes Schiavoni, Celia Guzmán, Agustín Ponzinibbio, and Jorge J. P. Furlong. "Mass Spectral Study of the Occurrence of Tautomeric Forms of Thiohydantoins." European Journal of Mass Spectrometry 13, no. 4 (2007): 291–306. http://dx.doi.org/10.1255/ejms.885.

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Mass spectrometry is used to evaluate the occurrence of thio-enol structures among the several possible tautomers of thiohydantoins and dithiohydantoins. Mass spectra of differently-substituted thiohydantoins are examined looking for common mass spectral behaviors to be predicted. Ion fragmentations from specific tautomers allow the most stable thio-enol structure for both type of compounds. The mass spectrum of the alkylation product of 5,5-dimethyldithiohydantoin and the nuclear magnetic resonance spectra of the alkylation products of both 2-thiohydantoin and dithiohydantoin support the fact

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3

CHACÓN, C., J. A. HENAO, J. JAMALIS, P. RIVAS, W. VELÁSQUEZ, and G. E. DELGADO. "SYNTHESIS, CRYSTAL STRUCTURE AND HIRSHFELD SURFACE ANALYSIS OF 1-ACETYL-5-(2-METHYLPROPYL)-2-THIOXO-IMIDAZOLIDIN- 4-ONE." Periódico Tchê Química 15, no. 29 (2018): 292–99. http://dx.doi.org/10.52571/ptq.v15.n29.2018.292_periodico29_pgs_292_299.pdf.

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The hydantoin and thiohydantoin heterocycles are present in a wide range of biologically active compounds including therapeutic drugs for the treatment of seizures and anti-tumor compounds. Thiohydantoins, have also been used as anti-convulsant agents and are present in fungicides, herbicides and natural products. However, the principal current interest comes from the application of thiohydantoins for the treatment of prostate cancers. Structural characterization of hydantoin and thiohydantoin are important to comprehend their effect mechanisms because of their considerable biological effects.

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4

Stanić, Petar, Marija Živković, and Biljana Šmit. "Synthesis and Characterization of Various Amino Acid Derived Thiohydantoins." Proceedings 9, no. 1 (2018): 37. http://dx.doi.org/10.3390/ecsoc-22-05690.

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Hydantoins and their sulfur containing analogues, thiohydantoins, are cyclic ureides that have attracted huge attention ever since their discovery. Most of them are biologically active compounds and several points of structural diversity have made them very synthetically attractive. Although substituents can be introduced to the hydantoin nucleus, most substituted hydantoins are synthesized from substrates already containing these groups, while forming the hydantoin nucleus. This is a common route to the synthesis of hydantoins and one of them is employed in this study. A series of 3-allyl-2-t

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5

Kobelev, Aleksandr I., Nikita A. Tretyakov, Ekaterina E. Stepanova, Maksim V. Dmitriev, Michael Rubin, and Andrey N. Maslivets. "Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea." Beilstein Journal of Organic Chemistry 15 (November 27, 2019): 2864–71. http://dx.doi.org/10.3762/bjoc.15.280.

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A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin–thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatography methods.

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6

Cejpek, K., and J. Velíšek. "Advances in Chemistry of Isothiocyanate-derived Colourants." Czech Journal of Food Sciences 27, Special Issue 1 (2009): S207—S210. http://dx.doi.org/10.17221/1092-cjfs.

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This study is focused on the reactions of isothiocyanates (ITCs) in the presence of amino compounds leading to coloured structures <I>via</I> substituted 2-thiohydantoins. A series of complementary experiments has been done and appropriate reaction conditions and structural prerequisites have been defined. Low-molecular colourants isolated and characterised from the model systems can be sorted into three groups. Yellow to red diastereomeric dehydrodimers of 2-thiohydantoin derivatives that contain an acidic methylene group are formed in mixtures consisted of ITCs and amino acids wi

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7

Zhang, Ranran, Junhong Liu, Hui Yan, Xingrong Peng, Ling Zhang, and Minghua Qiu. "Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)." Molecules 26, no. 16 (2021): 4934. http://dx.doi.org/10.3390/molecules26164934.

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Five new thiohydantoin derivatives (1–5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (1H and 13C NMR, 1H−1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds. Significantly, the structure of compound 1 was the first example of thiohydantoins with thioxohexahydroimidazo [1,5-a] pyridine moiety. Additionally, compounds 2 and 3 possess rare disulfide bonds. Except for compound 4, all isolates were assessed for neuroprotective activities in corticosterone (CORT)-stimulated PC12 cell damage. Among them, compound (−)-3 exhibited mo

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8

Geffken, Detlef, and Alf Ploetz. "Synthese von 6-Thioxo-1,2,5-oxadiazinan-3-onen und Umwandlung in 3-Amino-2-thiohydantoine und 3-Hydroxy-2-thiohydantoine / Synthesis of 6-Thioxo-1,2,5-oxadiazinan-3-ones and Transformation into 3-Amino-2-thiohydantoins and 3-Hydroxy-2-thiohydantoins." Zeitschrift für Naturforschung B 61, no. 1 (2006): 83–86. http://dx.doi.org/10.1515/znb-2006-0117.

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6-Thioxo-1,2,5-oxadiazinan-3-ones 5, easily available by cyclic thiocarbonylation of Nα ,Ndisubstituted α-aminocarbohydroxamic acids 4 with 1,1′-thiocarbonyldiimidazole, are transformed by hydrazine or hydroxylamine into 3-amino-2-thiohydantoins 6 and 3-hydroxy-2-thiohydantoins 7.

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9

Sleeckx, Jef J. M., Marc J. O. Anteunis, and Frans A. M. Borremans. "Proton magnetic resonance study of the conformation of the pyrrolidine ring in some proline-thiohydantoins." Collection of Czechoslovak Chemical Communications 53, no. 11 (1988): 2503–10. http://dx.doi.org/10.1135/cccc19882503.

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The conformational behaviour of a series of N-substituted thiohydantoins of proline was studied by proton NMR. The pseudorotational parameters of the proline moiety were calculated from the ten vicinal proton-proton coupling constants assuming a two state equilibrium (N ⇋ S). The effect of the different substituents (methyl, phenyl, para-nitrophenyl) at the thiohydantoin nitrogen on the conformation of the pyrrolidine rings is discussed. The spectra of proline-N-methylthiohydantoin were recorded at different temperatures in octadeuterotoluene solution. The conformational analysis of these spec

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10

Casagranda, F., BM Duggan, A. Kirkpatrick, RL Laslett, and JFK Wilshire. "Studies in Thiohydantoin Chemistry. II. C-Terminal Sequencing of Peptides." Australian Journal of Chemistry 49, no. 5 (1996): 551. http://dx.doi.org/10.1071/ch9960551.

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An investigation has been carried out into the thiocyanate degradation (AcOH/Ac2O/HSCN) procedure as it relates to the C-terminal sequencing of peptides, particular emphasis being placed on the sequencing of amino acid residues containing sensitive or functional side chains. Attempted C-terminal sequencing of several serine- and threonine -containing peptides stopped at these particular residues, and did not proceed further. It is concluded that sequencing of most of the common amino acids is achievable but that significant problems will have to be overcome before routine sequencing of proline

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11

de Carvalho, Priscila Goes Camargo, Jhonatan Macedo Ribeiro, Renata Perugini Biasi Garbin, et al. "Synthesis and Antimicrobial Activity of Thiohydantoins Obtained from L-Amino Acids." Letters in Drug Design & Discovery 17, no. 1 (2019): 94–102. http://dx.doi.org/10.2174/1570180816666181212153011.

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Background: Thiohydantoins are an important class of heterocyclic compounds in drug discovery since they are related to a wide range of biological properties including antimicrobial activity. Objective: The objective of this study was to synthesize a series of thiohydantoins derived from Laminoacids and to evaluated their inhibitory effect on the growth of Gram-negative and Grampositive bacteria. Methods: All title compounds were synthetized by reaction of L-amino acids with thiourea or ammonium thiocyanate. Their antimicrobial activities were evaluated against bacterial strains by broth micro

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12

Colebrook, Lawrence D. "A molecular mechanics study of conformational isomerism in 1- and 3-aryl hydantoins and 3-aryl-2-thiohydantoins." Canadian Journal of Chemistry 69, no. 12 (1991): 1957–63. http://dx.doi.org/10.1139/v91-281.

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Energy profiles for internal rotation about the C—N pivot bond in a series of 1- and 3-aryl hydantoins and 3-aryl-2-thiohydantoins have been computed using the MMX molecular mechanics force field. Rotational ground and transition states have been identified and their energies calculated. Conformational preferences of diastereomeric rotamers have been investigated. Computed rotational energy barriers generally are within ± 2 kcal/mol of the experimentally determined values. Key words: conformational isomerism, hindered rotation, hydantoins, thiohydantoins, molecular mechanics.

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13

DELGADO, G. E., Asiloé J. MORA, T. GONZÁLEZ, I. SANTOS, P. RIVAS, and L. E. SEIJAS. "SOLVENT-FREE SYNTHESIS AND CRYSTAL STRUCTURE OF rac-2-THIOHYDANTOIN-VALINE." Periódico Tchê Química 16, no. 31 (2019): 347–52. http://dx.doi.org/10.52571/ptq.v16.n31.2019.353_periodico31_pgs_347_352.pdf.

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Thiohydantoins have been used in the manufacture of medicines and in industrial processes. Depending on the nature and type of substitution on the heterocyclic ring, these compounds may display pharmaceutical and biological activity with a variety of applications as antiepileptic, antitumoral, antiinflammatory, and principally for the treatment of prostate cancer. In this study, a new thiohydantoin was synthetized from the valine amino acid and structurally characterized. The title compound, C6H10N2O2S, with systematic name rac-5-isopropyl-2-tioxoimidazolidin-4-one, has been synthetized by a s

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14

Saito, Rei, Naohiro Uemura, Hiroki Ishikawa, et al. "Umpolung cyclization reaction of N-cinnamoylthioureas in the presence of DBU." Organic & Biomolecular Chemistry 16, no. 42 (2018): 7910–19. http://dx.doi.org/10.1039/c8ob02066c.

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15

Tompkins, J. Ellsworth. "5,5-Diaryl-2-thiohydantoins and 5,5-diaryl N3-substituted 2-thiohydantoins as potential hypolipidemic agents." Journal of Medicinal Chemistry 29, no. 5 (1986): 855–59. http://dx.doi.org/10.1021/jm00155a042.

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16

Wang, Zerong, Samia Sheikh, and Yulu Zhang. "A Simple Synthesis of 2-Thiohydantoins." Molecules 11, no. 10 (2006): 739–50. http://dx.doi.org/10.3390/11100739.

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17

Metwally, Mohamed A., and Ehab Abdel-Latif. "Thiohydantoins: synthetic strategies and chemical reactions." Journal of Sulfur Chemistry 33, no. 2 (2012): 229–57. http://dx.doi.org/10.1080/17415993.2011.643550.

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18

Zhang, Wei, and Yimin Lu. "Fluorous Synthesis of Hydantoins and Thiohydantoins." Organic Letters 5, no. 14 (2003): 2555–58. http://dx.doi.org/10.1021/ol034854a.

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19

Golovko, T. V., V. A. Parshin, V. V. Asnina, et al. "Nootropic activity of ureidoacids and thiohydantoins." Pharmaceutical Chemistry Journal 24, no. 4 (1990): 260–63. http://dx.doi.org/10.1007/bf00764413.

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20

Haslak, Zeynep Pinar, Sesil Agopcan Cinar, Sevgi Sarigul Ozbek, Gérald Monard, Ilknur Dogan, and Viktorya Aviyente. "Elucidation of the atroposelectivity in the synthesis of axially chiral thiohydantoin derivatives." Organic & Biomolecular Chemistry 18, no. 12 (2020): 2233–41. http://dx.doi.org/10.1039/c9ob02556a.

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A DFT study is carried out in order to elucidate the racemization and cyclization mechanism as well as the atroposelectivity during the synthesis of 2-thiohydantoins. Computational data shows that the racemization occurs after cyclization with the assistance of triethyl amine.

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21

Thakar, K. M., D. J. Paghdar, P. T. Chovatia, and H. S. Joshi. "Synthesis of thiourea derivatives bearing the benzo[b]thiophene nucleus as potential antimicrobial agents." Journal of the Serbian Chemical Society 70, no. 6 (2005): 807–15. http://dx.doi.org/10.2298/jsc0506807t.

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The synthesis of a group of thiohydantoins and thiobarbiturates derived from 2-N-arylthiopyridocarbonyl-3,5-dichlorobenzo[b]thiophene is described. The structures of the new compounds are supported by IR, 1H-NMR and mass spectral data. These compounds were tested in vitro for their antimicrobial activities.

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22

Takahashi, Asaka, Hiroki Matsuoka, and Yasushi Uda. "Presence of 2-Thiohydantoins in Processed Foods." Nippon Shokuhin Kagaku Kogaku Kaishi 52, no. 12 (2005): 610–14. http://dx.doi.org/10.3136/nskkk.52.610.

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23

L. Gleason, James, and Timothy A. Cernak. "Synthesis of 5-Chloromethylene Hydantoins and Thiohydantoins." HETEROCYCLES 71, no. 1 (2007): 117. http://dx.doi.org/10.3987/com-06-10914.

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24

Takahashi, Asaka, Hiroki Matsuoka, Yoshio Ozawa, and Yasushi Uda. "Antimutagenic Properties of 3,5-Disubstituted 2-Thiohydantoins." Journal of Agricultural and Food Chemistry 46, no. 12 (1998): 5037–42. http://dx.doi.org/10.1021/jf980430x.

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25

Ceban, Victor, Kane Hands, Marta Meazza, Mark E. Light, and Ramon Rios. "Three-component diastereoselective cascade synthesis of thiohydantoins." Tetrahedron Letters 54, no. 52 (2013): 7183–87. http://dx.doi.org/10.1016/j.tetlet.2013.10.110.

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26

Tatibouët, Arnaud, Sandrine Gosling, and Chahrazade El Amri. "Staudinger Condensation for the Preparation of Thiohydantoins." Synthesis 46, no. 08 (2014): 1079–84. http://dx.doi.org/10.1055/s-0033-1338592.

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27

Ryczek, Józef. "Synthesis of 3-Ω-amino-2-thiohydantoins". Journal of Heterocyclic Chemistry 40, № 4 (2003): 665–70. http://dx.doi.org/10.1002/jhet.5570400417.

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28

Маргарита Григорьевна, Абрамянц,, Одарюк, Иван Дмитриевич, Кравченко, Елена Михайловна та Ломов, Дмитрий Александрович. "SYNTHESIS AND STUDY OF THE CHEMILUMINESCENT PROPERTIES OF CONDENSED THIOHYDANTOINS OF THE SERIES OF SPINACIN AND TETRAHYDRO-β-CARBOLINE". Вестник Тверского государственного университета. Серия: Химия, № 4(50) (18 січня 2023): 121–31. http://dx.doi.org/10.26456/vtchem2022.4.15.

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Усовершенствованным методом синтезирован ряд производных конденсированных тиогидантоинов спинацина и β -карболина. Полученные соединения обладают интенсивной хемилюминесценцией в щелочных растворах диметилсульфоксида и диметилформамида. A number of derivatives of condensed thiohydantoins spinacin and β carboline have been synthesized by an improved method. The resulting compounds have intense chemiluminescence in alkaline solutions of dimethyl sulfoxide and dimethylformamide.

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29

Chen, Yu, Li Su, Xinying Yang, Wenyan Pan, and Hao Fang. "Enantioselective synthesis of 3,5-disubstituted thiohydantoins and hydantoins." Tetrahedron 71, no. 49 (2015): 9234–39. http://dx.doi.org/10.1016/j.tet.2015.10.041.

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30

Porwal, Sharad, Rishi Kumar, Prakas R. Maulik, and Prem M. S. Chauhan. "A multicomponent reaction efficiently producing arylmethylene 2-thiohydantoins." Tetrahedron Letters 47, no. 33 (2006): 5863–66. http://dx.doi.org/10.1016/j.tetlet.2006.06.076.

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31

Metwally, Mohamed A., and Ehab Abdel-Latif. "ChemInform Abstract: Thiohydantoins: Synthetic Strategies and Chemical Reactions." ChemInform 43, no. 28 (2012): no. http://dx.doi.org/10.1002/chin.201228261.

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32

Ivanenkov, Yan A., Maxim E. Kukushkin, Anastasia A. Beloglazkina, et al. "Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity." Molecules 28, no. 3 (2023): 1325. http://dx.doi.org/10.3390/molecules28031325.

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Novel variously substituted thiohydantoin-based dispiro-indolinones were prepared using a regio- and diastereoselective synthetic route from 5-arylidene-2-thiohydantoins, isatines, and sarcosine. The obtained molecules were subsequently evaluated in vitro against the cancer cell lines LNCaP, PC3, HCTwt, and HCT(−/−). Several compounds demonstrated a relatively high cytotoxic activity vs. LNCaP cells (IC50 = 1.2–3.5 µM) and a reasonable selectivity index (SI = 3–10). Confocal microscopy revealed that the conjugate of propargyl-substituted dispiro-indolinone with the fluorescent dye Sulfo-Cy5-az

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33

Machado, Olga L. T., Patricia D. Ribeiro, Ronaldo S. M. Borges, Paulo R. R. Costa, and Elias W. Alves. "Carboxyl-terminal sequencing: new c-terminal peptidyl-thiohydantoins formation conditions." Protein & Peptide Letters 5, no. 5 (1998): 251–56. http://dx.doi.org/10.2174/092986650505221111091512.

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Abstract: The present study explores conditions to activate the carboxyl group before the coupling of C-terrninus-AA with TMS-ITC. N-tert-butoxy-carbonyl amino acids (Boc-AAs) and Leucine Enkephalin were used as models and isobutyl chloroformate was used as a C-terminal activator. The reaction coupling activated AA with TMS ITC was temperature dependent. We also·report here a new, efficient, economical and ecological technique to separate the mixture of amino acids thiohydantoins (TH-AA).

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34

Yeh, Wen-Ben, Mei-Jung Lin, Ming-Juan Lee, and Chung-Ming Sun. "Microwave-enhanced liquid-phase synthesis of thiohydantoins and thioxotetrahydropyrimidinones." Molecular Diversity 7, no. 2-4 (2003): 185–98. http://dx.doi.org/10.1023/b:modi.0000006802.21361.29.

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35

Dürüst, Yasar, and Fatma Nohut. "A New And Convenient Synthesis Of Some Substituted Thiohydantoins." Synthetic Communications 29, no. 11 (1999): 1997–2005. http://dx.doi.org/10.1080/00397919908086188.

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36

Baccolini, Graziano, Carla Boga, Camilla Delpivo, and Gabriele Micheletti. "Facile synthesis of hydantoins and thiohydantoins in aqueous solution." Tetrahedron Letters 52, no. 14 (2011): 1713–17. http://dx.doi.org/10.1016/j.tetlet.2011.02.002.

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37

Uemura, Naohiro, Momoka Hosaka, Aoi Washio, Yasushi Yoshida, Takashi Mino, and Masami Sakamoto. "Chiral Symmetry Breaking of Thiohydantoins by Attrition-Enhanced Deracemization." Crystal Growth & Design 20, no. 8 (2020): 4898–903. http://dx.doi.org/10.1021/acs.cgd.0c00829.

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38

Ceban, Victor, Kane Hands, Marta Meazza, Mark E. Light, and Ramon Rios. "ChemInform Abstract: Three-Component Diastereoselective Cascade Synthesis of Thiohydantoins." ChemInform 45, no. 17 (2014): no. http://dx.doi.org/10.1002/chin.201417134.

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39

Gosling, Sandrine, Chahrazade El Amri, and Arnaud Tatibouet. "ChemInform Abstract: Staudinger Condensation for the Preparation of Thiohydantoins." ChemInform 45, no. 40 (2014): no. http://dx.doi.org/10.1002/chin.201440142.

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40

Guk, Dmitry A., Olga O. Krasnovskaya, Nikolai V. Zyk, and Elena K. Beloglazkina. "Convenient Synthesis of 2-Thioimidazolone/Menadione Conjugates via a Two-Step Sequence Starting with Direct Amination of Menadione." SynOpen 04, no. 02 (2020): 38–43. http://dx.doi.org/10.1055/s-0040-1707519.

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A convenient route to conjugates of 2-thiohydantoins and menadione with linkers of various chemical nature through a two-stage reaction sequence (direct amination of the menadione with a functional amine followed by modification of a functional group) is presented. Optimal conditions for the direct amination of menadione using alkyl amines with substituents such as azide, alkyne, hydroxyl, amine, halogen, and carboxyl have been developed. Further modification of selected functionalities using CuAAC or esterification reactions with 2-thiohydantoines has been performed.

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41

Kukushkin, Maxim E., Nikita A. Karpov, Dmitry E. Shybanov, Nikolai V. Zyk, and Elena K. Beloglazkina. "A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins." Mendeleev Communications 32, no. 1 (2022): 126–28. http://dx.doi.org/10.1016/j.mencom.2022.01.041.

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42

Machácek, Vladimír, Petr Jansa, Valerio Bertolasi, and Vladimír Wsól. "Hydantoins and Thiohydantoins Derived from 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid." HETEROCYCLES 68, no. 12 (2006): 2527. http://dx.doi.org/10.3987/com-06-10878.

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43

El-barbary, Ahmed A., Youssef L. Aly, Abdel-Fatah M. Hashem, and Ashraf A. El-shehawy. "REACTION OF 2-THIOHYDANTOINS WITH SOME DIAZOALKANES AND SOME AMINES." Phosphorus, Sulfur, and Silicon and the Related Elements 160, no. 1 (2000): 77–91. http://dx.doi.org/10.1080/10426500008043673.

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44

Hashmi, Imran Ali, Afshan Aslam, Syed Kashif Ali, Viqar-uddin Ahmed, and Firdous Imran Ali. "Synthesis of Hydantoins, Thiohydantoins, and Glycocyamidines Under Solvent-Free Conditions." Synthetic Communications 40, no. 19 (2010): 2869–74. http://dx.doi.org/10.1080/00397910903320662.

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45

Kumar, Vipan, Vishu Mehra, Parvesh Singh та Neha Manhas. "β-Lactam-Synthon-Interceded Facile Synthesis of Functionally Decorated Thiohydantoins". Synlett 25, № 08 (2014): 1124–26. http://dx.doi.org/10.1055/s-0033-1341049.

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46

Reyes-González, Ulises F., Edson Barrera, Daniela Martínez-López, et al. "Synthesis of exocyclic enaminone-based thiohydantoins as potent antifungal agents." Tetrahedron 167 (November 2024): 134286. http://dx.doi.org/10.1016/j.tet.2024.134286.

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Matthews, Jay, and Ralph A. Rivero. "Base-Promoted Solid-Phase Synthesis of Substituted Hydantoins and Thiohydantoins." Journal of Organic Chemistry 62, no. 17 (1997): 6090–92. http://dx.doi.org/10.1021/jo970521d.

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Ahmedova, Anife, Gordana Pavlović, Marin Marinov, Neyko Stoyanov, Dubravka Šišak, and Mariana Mitewa. "Two cycloalkanespiro-5-(2-thiohydantoins): Synthesis, spectral and structural characterization." Journal of Molecular Structure 938, no. 1-3 (2009): 165–73. http://dx.doi.org/10.1016/j.molstruc.2009.09.021.

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Wang, Xin, David Mealer, Lacey Rodgers, et al. "Synthesis of 2-Thiohydantoins as Somatostatin Subtype 4 Receptor Ligands." Letters in Drug Design & Discovery 9, no. 7 (2012): 655–62. http://dx.doi.org/10.2174/157018012801319445.

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Reyes, Samuel, and Kevin Burgess. "On Formation of Thiohydantoins from Amino Acids under Acylation Conditions." Journal of Organic Chemistry 71, no. 6 (2006): 2507–9. http://dx.doi.org/10.1021/jo052576i.

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