Academic literature on the topic 'Thyroid peroxidase antibodies'
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Journal articles on the topic "Thyroid peroxidase antibodies"
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Izquierdo, MD, Roberto. "Editorial: THYROID PEROXIDASE ANTIBODIES." Endocrine Practice 6, no. 3 (May 2000): 278–79. http://dx.doi.org/10.4158/ep.6.3.278.
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Balzer, K., J. Diener, K. Wegscheider, R. Vaupel, F. Grünwald, and N. Döbert. "Thyroid sonomorphology, thyroid peroxidase antibodies and thyroid function." Nuklearmedizin 47, no. 05 (2008): 194–99. http://dx.doi.org/10.3413/nukmed-0166.
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Summary Aim: Employees of Sanofi-Aventis Deutschland GmbH underwent thyroid screening in 2006 to assess new data about the prevalence of irregular sonomorphological pattern, elevated thyroid peroxidase antibodies (TPO AB) and thyroid function in an unselected adult German population. Participants, methods: The examination included 700 unselected employees. Blood samples were analyzed for serum TSH and TPO AB, and ultrasound of the thyroid was performed. Results: In 40.7% of the participants (n = 285) an irregular sonomorphological pattern was detected: goiter in 13.7%, nodules in 35.6%, nodular goiter in 8.6% and a hypoechogenic pattern of the thyroid gland in 20.4%. Serum TSH was increased in 3.9% and decreased in 0.6%. Elevated TPO AB values were observed in 13%. Only 1.4% (n= 10) showed elevated TPO AB combined with a TSH increase. Sonomorphological abnormalities were associated with increased TPO AB in 7.1%. Elevated TPO AB was observed significantly more often in combination with sonomorphological pathology (54.9%) than without (45.1%) (p = 0.003). Conclusions: Sonomorphological disorders are still very common in Germany and our results are comparable with previous screening examinations. Elevated TPO AB correlated significantly with the sonomorphological pattern of nodules and goiter. This may reflect an improved iodine supply or a hypertrophic stage of autoimmune thyroiditis in some cases.
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Bogner, Ulrich, Peter Kotulla, Harm Peters, and Horst Schleusener. "Thyroid peroxidase/microsomal antibodies are not identical with thyroid cytotoxic antibodies in autoimmune thyroiditis." Acta Endocrinologica 123, no. 4 (October 1990): 431–37. http://dx.doi.org/10.1530/acta.0.1230431.
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Abstract. Cytotoxic activity in sera of patients with Hashimoto's thyroiditis was measured with an antibody-dependent cell-mediated cytotoxicity assay. Cytotoxicity was determined in a 51chromium release assay using human thyroid cell targets incubated with heat-inactivated serum or IgG from patients with Hashimoto's thyroiditis. Effector cells were obtained from peripheral mononuclear cells of normal subjects. Cytotoxicity was significantly increased in patients with Hashimoto's thyroiditis (median specific lysis 20.2%, range 2.1-58.8) compared with normals (median specific lysis 8.1%, range 0-19.5; p<0.00001). The amount of percent specific lysis did not correlate with the titres of microsomal antibodies determined by different methods: passive hemagglutination technique (r=0.2), enzyme immunoassay with microsomal antigen (r=0.16), and radioimmunoassay for thyroid peroxidase antibody (r=0.02). The cytotoxic activity was located in the IgG fraction, both in microsomal antibody positive and negative sera. After pre-incubation of microsomal antibody/thyroid peroxidase antibody positive or negative sera with purified thyroid peroxidase followed by analysis in the antibody-dependent cell-mediated cytotoxicity assay, cytotoxicity decreased in only 2 cases but was unchanged in the remaining sera. Western blot experiments with solubilized thyroid membranes and immunoblotting with cytotoxic-positive/microsomal antibody negative sera showed no binding to thyroid peroxidase. Our data suggest that cytotoxicity in sera from patients with Hashimoto's thyroiditis is not mediated by antibodies against thyroid peroxidase, but by antibodies not yet identified.
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Bech, Karine, Mimi Høier-Madsen, Ulla Feldt-Rasmussen, Bente Møller Jensen, Lars Mølsted-Pedersen, and Claus Kühl. "Thyroid function and autoimmune manifestations in insulin-dependent diabetes mellitus during and after pregnancy." Acta Endocrinologica 124, no. 5 (May 1991): 534–39. http://dx.doi.org/10.1530/acta.0.1240534.
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Abstract. Insulin-dependent diabetes is associated with other autoimmune diseases and subclinical hypothyroidism has been reported in pregnant diabetic women. We studied the thyroid function of 85 women with diabetes during pregnancy and after delivery, as well as various autoantibodies. During pregnancy, thyroid microsomal antibodies were present in 17/85, antibodies against thyroid peroxidase in 16/85, thyroglobulin antibodies in 2/85, parietal cell antibodies in 23/85, adrenal antibodies in 4/77, rheumatoid factor in 15/85, and thyroid-stimulating antibodies in 43/85. Presence of antibodies was not combined with thyroid dysfunction, but TSH and HbA1c was increased (p<0.005) in women with thyroid antibodies. The gestational age of the infants was lower (p<0.01) in women with positive thyroid-stimulating antibody titre, whereas the ponderal index was only lower in those with peroxidase antibodies (p<0.05). After delivery, microsomal and peroxidase antibodies were positive in 10 (17.5%) of 57 patients followed. Six women developed postpartum thyroiditis (10.5%), of whom 5 were positive for both microsomal and peroxidase antibodies; two of those showing a hyperthyroid phase also had positive thyroid-stimulating antibody titre. We conclude that autoantibodies occur with increased incidence in pregnant diabetic women. Thyroid antibodies are related to a slightly reduced thyroid capacity and involve a high risk of postpartum thyroiditis. Further, thyroid antibodies seem to influence the nutritional status of the infant.
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Khan, Sara, Sibgha Bashir, Faghia Shahid, Ayesha Siddiqa, Muhammad Rizwan Hafeez, and Sarmad Mehmood. "Comparison of the Frequency of Raised Level of Anti-Thyroid Peroxidase Antibody in the Patients of Hypothyroidism and the Euthyroids." NUST Journal of Natural Sciences 5, no. 1 (May 29, 2021): 2–8. http://dx.doi.org/10.53992/njns.v5i1.31.
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The goal of this study was to compare the frequency of raised level of anti-thyroid peroxidase antibody in patients of hypothyroidism and the euthyroids. This case-control study was carried out at the department of Pathology, Quaid e Azam Medical College/Bahawal Victoria Hospital, Bahawalpur, from October 1, 2018 to Setember 30, 2019 and the subjects were selected by the non-probabilty consecutive sampling technique. The frequency of raised level of anti-thyroid peroxidase antibody in patients of hypothyroidism and the euthyroids was compared. In the present study, the mean age of the patients with cases of hypothyroidism was 32 ± 10 years, and the mean age of controls was 32 ± 10 years. Raised anti-thyroid peroxidase antibodies were found in 20 (28.99%) cases and 5 (7.25%) controls. After applying a Chi-squared test, a statistically significant (P = .00) difference in the level of anti-thyroid peroxidase antibodies between the cases and controls was detected. The presence of raised anti-thyroid peroxidase antibodies was also significantly associated with age and female gender. In conclusion the early screening of the anti-thyroid peroxidase antibodies specially in women above 30-years would notably affect the outcome of the disease with congruent disease management.he euthyroids was compared. In the present study, the mean age of the patients with cases of hypothyroidism was 32 ± 10 years, and the mean age of controls was 32 ± 10 years. Raised anti-thyroid peroxidase antibodies were found in 20 (28.99%) cases and 5 (7.25%) controls. After applying a Chi-squared test, a statistically significant (P = .00) difference in the level of anti-thyroid peroxidase antibodies between the cases and controls was detected. The presence of raised anti-thyroid peroxidase antibodies was also significantly associated with age and female gender. In conclusion the early screening of the anti-thyroid peroxidase antibodies specially in women above 30-years would notably affect the outcome of the disease with congruent disease management.
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Yucel, Idris, Yasemin Kemal, Guzin Gonullu, and Kubilay Ekiz. "Thyroid peroxidase antibodies in breast cancer." Journal of Clinical Oncology 32, no. 15_suppl (May 20, 2014): e22211-e22211. http://dx.doi.org/10.1200/jco.2014.32.15_suppl.e22211.
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P., Jishna, M. P. Binitha, Abdul Latheef E. N., and V. P. Anilakumari. "Prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in vitiligo patients." International Journal of Research in Dermatology 3, no. 1 (February 23, 2017): 140. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20170803.
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<p class="abstract"><strong>Background:</strong> Vitiligo is associated with various autoimmune diseases, including autoimmune thyroid disease. The objectives of the present study was to determine the prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in patients with vitiligo, and to compare the clinical profile of anti-thyroid peroxidase positive and anti-thyroid peroxidase negative patients<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> A cross-sectional comparative study was conducted in 100 patients with vitiligo and 100 controls. After dermatologic and systemic evaluation, serum thyroid hormones and anti-thyroid peroxidase antibody levels were measured in all the subjects.<strong></strong></p><p class="abstract"><strong>Results:</strong> Thyroid dysfunction was more common in the vitiligo group (27%) than in the controls. Serum thyroid stimulating hormone abnormalities were more common in the vitiligo group (27%) than in the controls (6%). The most common thyroid dysfunction was subclinical hypothyroidism. Anti-thyroid peroxidase antibody positivity was higher in the vitiligo group (36%) when compared to the controls (24%), and the most common type of vitiligo was vitiligo vulgaris (18%) in this group. Thyroid dysfunction and anti-thyroid peroxidase positivity were more common in women (58%) when compared to men (42%). There was a significantly higher prevalence of other autoimmune diseases in the vitiligo group (20%) compared to the controls (6%)<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> This study shows a significant association between vitiligo and thyroid dysfunction, anti-thyroid peroxidase antibodies and other autoimmune diseases. We recommend that thyroid evaluation and regular follow-up should be done in patients with vitiligo for prompt detection of thyroid dysfunction<span lang="EN-IN">.</span></p>
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Fadeyev, V. V., S. V. Lesnikova, and G. A. Melnichenko. "Thyroid function in pregnant females carrying thyroid peroxidase antibodies." Problems of Endocrinology 49, no. 5 (October 15, 2003): 23–29. http://dx.doi.org/10.14341/probl11734.
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То define risk factors for gestational hypothyroxinemia in females carrying thyroid peroxidase antibodies (TPO Ab) during pregnancy, a study was performed, which included 73 females at different periods of pregnancy in accordance with the following criteria: the lack of impaired dysfunction of the thyroid gland (TG) on primary examination; elevated TPO Ab levels (more than 100 mEU/l; no history of TG pathology. The control group comprised 128 pregnant females without TG pathology. Evaluation of TG function in females with TPO Ab who received and did not the physiological doses of iodine revealed that the function did not differ by the end of pregnancy. The odds ratio for hypothyroxinemia in pregnant females with more than 100 mEU/l of TPO Ab was 3.14. In a subgroup of females with TPO Ab and the enlarged TG in the second trimester, the level of fT4 was significantly lower and that of thyroid-stimulating hormone (TSH) was significantly higher than those in the control group. Logistic regression analysis indicated that a relatively high level of TSH in early gestation was most significant in females with TPO Ab. It is concluded that it is expedient to consider whether preventive levothyroxine therapy is performed in females who carry TPO Ab with the enlarged TG and with TSH level that is relatively high (more than 2 mMe/l) for early pregnancy.
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Dr Minny Mary Mammen, Dr Simi Sam,. "Study of Antithyroid Peroxidase Antibodies in People with Normal Range Thyroid Stimulating Hormone." Journal of Medical Science And clinical Research 05, no. 02 (February 26, 2017): 18119–25. http://dx.doi.org/10.18535/jmscr/v5i2.141.
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Feldt-Rasmussen, U., M. Høier-Madsen, J. Date, and M. Blichert-Toft. "Evidence for acute release of thyroid peroxidase during subtotal thyroidectomy." Acta Endocrinologica 124, no. 6 (June 1991): 661–65. http://dx.doi.org/10.1530/acta.0.1240661.
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Abstract. An immediate reduction of thyroglobulin autoantibodies during subtotal thyroidectomy of thyroglobulin antibody positive patients has previously been shown to indicate an acute release of thyroglobulin into the circulation peroperatively. The aim of the present study was to investigate whether thyroid peroxidase was also released by measuring anti-thyroid peroxidase antibodies by a quantitative and antigen specific method both per- and postoperatively in patients positive for anti-thyroid peroxidase antibodies. Twelve anti-thyroid peroxidase positive patients (11 females, 1 male) referred for surgery of toxic goitre were studied. Median age was 43 years (range 24-64) and median goitre size 86 g (25-165). All patients had been pretreated with antithyroid drugs and were euthyroid at the time of operation. Anti-thyroid peroxidase was measured before operation, 1-8 h, 10 days, 1-3 months, and 12 months postoperatively by a commercial method (DYNO-test®, Henning, Berlin). The median anti-thyroid peroxidase level before operation was 1048 kU/l (range 68-10 517 kU/l) and fell during operation to 0.63 (range 0.37-1.28) (p<0.01) of initial concentration without further decrease during the next 1-8 h. The comparative decrease in thyroglobulin antibodies was 0.19 (0-0.88). The anti-thyroid peroxidase level was increasing after 10 days, but did not reach initial level until between 3 and 12 months after surgery. However, in 3 of 10 patients anti-thyroid peroxidase had disappeared after 12 months, all of whom had low levels before operation, whereas anti-thyroid peroxidase was 2-4 times higher than preoperatively in 3 other patients. The present study thus gives evidence for an acute release of thyroid peroxidase into the circulation during thyroid surgery able to decrease anti-thyroid peroxidase activity almost to the same degree as the Tg-induced decrease in Tg-ab.
Dissertations / Theses on the topic "Thyroid peroxidase antibodies"
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Ewins, David Laurence. "Characterisation of autoantigenic epitopes on thyroid peroxidase recognised by antibodies and T lymphocytes in autoimmune thryroid disease." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240770.
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Lidén, Pauline. "Kan selentillskott behandla autoimmun tyreoidit? : En litteraturstudie." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-77978.
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Introduktion. Autoimmun tyreoidit (AITD) är en kronisk autoimmun sjukdom där immunförsvarets antikroppar (ab) attackerar tyreoideaproteinerna tyreoideaperoxidas (TPO) och/eller tyreoglobulin (TG). Studier visar att selentillskott hos patienter med AITD kan minska tyreoideaantikroppar, storleken och antalet noduler hos en förstorad tyreoidea. Syftet med detta arbete var att undersöka hur selentillskott påverkar serumnivåer av TPOab, samt tyreoideahormonnivåer vid AITD. Metod. Arbetet är en litteraturstudie och därför har metoden varit att samla relevant litteratur genom PubMed med sökningar som ”selenium autoimmune thyroiditis”, ”selenium thyroid” och ”autoimmune thyroiditis”. Bland sökresultaten valdes nio artiklar ut baserat på studiekvalitet, publikationsår och relevans. Bland artiklarna granskades och sammanställdes uppmätta nivåer av TPOab samt tyreoideahormonnivåer, vilka valdes som indikation på effekt utav selentillskott. Resultat. Resultaten var inkonsekventa. Majoriteten av studierna (7 av 9) tydde på att oral administrering av selentillskott effektivt minskade serumkoncentrationerna av TPOab hos patienter med AITD i alla åldersgrupper. De studier som resulterade i störst minskning av TPOab pågick i 3-12 månader. Utav de 9 studerade artiklarna var det endast en studie som inte rapporterade någon som helst positiv klinisk effekt hos patienterna. Två av studierna visade att selen förhindrar vidare försämring av tyreoideans ekogenitet, vilket tyder på att selen kan hejda inflammationsprocessen men ej reversera tyreoideaskadorna den orsakat. Majoriteten av studierna (7 av 9) visade att selentillskott ej ger några signifikanta förändringar i tyreoideahormonerna: TSH, fT4 och fT3. Diskussion. Varför AITD-patienter svarar olika på selenadministrering är ännu okänt, men kan misstänkas bero på selenbehandlingens varaktighet, patienternas intratyroidnivåer av selen vid studiens början, förekomst av jodbrist, samt patienternas ålder och sjukdomsprogression. Slutsats. Att ha adekvata fysiologiska nivåer av selen är av stor vikt för att bevara tyreoideans hälsa och förebygga tyreoidearelaterade sjukdomar. Majoriteten utav de granskade studierna visar att tillskott av selen kan minska antalet TPOab. Selentillskott kan även ha immunrelaterade fördelar men verkar inte påverka nivån tyreoideahormonnivåer. Inga negativa effekter påvisades vid intag av selentillskott vilket gör dess administrering säker. Fler studier behöver dock göras för att fastställa effektiviteten av selentillskott vid AITD.Introduction. Autoimmune thyroiditis (AITD) is a chronic autoimmune disease in which the immune system's antibodies (ab) attack the thyroid proteins thyroid peroxidase (TPO) and/or thyroglobulin (TG). Studies show that selenium supplementation in patients with AITD can reduce thyroid antibodies and the size and number of nodules in an enlarged thyroid. The purpose of this study was to investigate how selenium supplementation affects the serum levels of thyroid peroxidase antibodies (TPOab) and thyroid hormone levels in autoimmune thyroiditis. Method. This is a literature study and therefore the method has been to gather relevant literature through searches on PubMed such as "selenium autoimmune thyroiditis", "selenium thyroid" and "autoimmune thyroiditis". Among the search results, nine articles were selected based on quality, publication year and relevance. Among the articles, measured levels of TPOab and thyroid hormone levels were examined and compiled, and were chosen as an indication of the effect of selenium supplementation. Results. The results were inconsistent. The majority of the studies (7 of 9) suggest that oral administration of selenium supplements effectively reduced serum concentrations of TPOab in patients with AITD in all age groups. The studies that resulted in the largest decrease in TPOab lasted for 3-12 months. Out of the 9 examined studies, only one study did not report any positive clinical effect in patients. Two of the studies showed that the selenium prevents further impairment of thyroid echogenicity, suggesting that selenium can inhibit the inflammatory process but not reverse the pre-existing thyroid damage it’s caused. The majority of studies (7 out of 9) show that selenium supplementation does not produce significant changes in the thyroid hormones: TSH, fT4 and fT3. Discussion. Why AITD-patients respond differently to selenium administration is still unknown, but it may be due to the duration of selenium treatment, the patients' intrathyroid levels of selenium at the onset of the study, the presence of iodine deficiency, as well as the age and disease progression of the patients. Conclusion. Having adequate physiological levels of selenium is of great importance in preserving thyroid health and preventing thyroid-related diseases. The majority of the studies show that selenium supplementation can reduce the number of TPOab. Selenium supplementation may also have immune related benefits but does not appear to affect the thyroid hormone levels. No adverse effects were observed during selenium supplementation, which makes its administration safe. However, more studies are needed to determine the effectiveness of selenium supplementation for AITD.
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Lume, Inês Catarina Moreira dos Santos Correia. "Clinical relevance of antithyroid antibodies in thyroid disease : a retrospective study." Master's thesis, 2020. http://hdl.handle.net/10451/46765.
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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2020Introdução: A doença tiroideia autoimune é uma doença autoimune prevalente, contudo os papéis funcional e clínico dos anticorpos anti-tiroideus permanecem por esclarecer. Objetivos: Comparar os anticorpos antitiroideus e parâmetros de função tiroideia em dois pontos do tempo distintos do seguimento e identificar possíveis correlações entre os anticorpos anti-tiroideus e parâmetros de função tiroideia, na tiroidite de Hashimoto. Doentes e Métodos: Neste estudo retrospetivo observacional, estudámos uma base de dados de 346 doentes com tiroidite de Hashimoto seguidos no Hospital de Santa Maria – Centro Hospitalar Universitário Lisboa Norte, de 2009 ± 6 a 2014 ± 3. A análise estatística foi realizada para detetar diferenças entre as hormonas e anticorpos tiroideus séricos nas primeira e última consultas do seguimento e para inferir sobre correlações entre as hormonas e anticorpos tiroideus. Resultados: Verificou-se uma redução significativa de TSH, T3, T4 e TPOAb, e um aumento significativo de fT4 entre consultas. Correlações modestas e positivas entre TPOAb e TgAb, TPOAb e TSH, e TPOAb e fT4 foram descritas na primeira consulta. Uma correlação modesta negativa entre TgAb e Tg foi documentada nas duas consultas. Identificámos subgrupos de doentes que produziam preferencialmente TPOAb ou TgAb, e aqueles que tinham medições positivas de Tg apesar de medições positivas de TgAb. Conclusão: As alterações nos anticorpos anti-tiroideus e função tiroideia observadas no seguimento destes doentes mostra que a tiroidite de Hashimoto não é uma doença imutável. A correlação entre TPOAb e fT4 e TSH poderá sugerir a importância deste anticorpo na tiroidite de Hashimoto. As diferenças na expressão de TPOAb e TgAb em diferentes subgrupos de doentes poderão refletir a evolução natural da tiroidite de Hashimoto, um fenómeno aleatório ou uma situação clínica distinta. Palavras-Chave: anticorpos anti-tiroideus; doença tiroideia autoimune; tiroidite de Hashimoto; anticorpo anti-peroxidase tiroideia; anticorpo anti-tiroglobulina.
Background: Autoimmune thyroid disease is a prevailing autoimmune disorder, however the functional and clinical roles of antithyroid antibodies have not been fully elucidated. Objectives: To compare antithyroid antibodies and thyroid function parameters between two points in time of follow-up and to identify possible relations between antithyroid antibodies and thyroid function parameters, in Hashimoto’s thyroidits. Patients and Methods: In this retrospective observational study, we studied a database comprising 346 patients with Hashimoto’s thyroiditis assisted at Hospital de Santa Maria – Centro Hospitalar Universitário Lisboa Norte, from 2009 ± 6 to 2014 ± 3. Statistical data analysis was conducted to detect differences in thyroid hormones and antibodies in serum at two different points in time (first visit and last visit of follow-up) and to infer from correlations between antithyroid antibodies and thyroid function tests. Results: There was a significant reduction of TSH, T3, T4 and TPOAb, and a significant increase of fT4 between visits. Significant modest positive correlations between TPOAb and TgAb levels, TPOAb and TSH levels and TPOAb and fT4 levels were found at the first visit. A significant weak negative correlation between TgAb and Tg levels was reported for both visits. We identified subsets of patients who preferentially produce TPOAb or TgAb, and those who had positive Tg despite positive TgAb. Conclusion: The follow-up change we observed in antithyroid antibodies and thyroid function shows us that Hashimoto’s thyroiditis is not an immutable disease. The correlation between TPOAb and fT4 and TSH might suggest this antibody’s importance in Hashimoto’s thyroiditis pathogenesis. The difference in TPOAb and TgAb expression in distinct patient subsets could reflect the evolution of Hashimoto’s thyroiditis, a random phenomenon or a different clinical situation altogether. Keywords: antithyroid antibodies; autoimmune thyroid disease; Hashimoto’s thyroiditis; anti-thyroid peroxidase antibody; anti-thyroglobulin antibody.
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Bartáková, Jana. "Ekonomické aspekty screeningu tyreopatií v graviditě a u žen s poruchou fertility." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-352094.
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The incidence of thyroid diseases in pregnancy in the Czech Republic reaches 10- 15%. Emphasis on early diagnosis and treatment is laid not only during pregnancy but also in the time preceding conception due to the impact of thyroid diseases on fertility, the course of pregnancy, birth and fetal development. The aim of the dissertation was to assess the effectiveness and economical aspects of screening for thyroid disease in pregnancy and in women with fertility disorders in the conditions of the Czech Republic. The dissertation consists of four published studies. The first study is a prospective cross-sectional study of 200 positively screened pregnant women. In the study we come to conclusion that pregnant women who are at high- and low-risk for thyroid disease have similar clinical and laboratory characteristics and screening, currently focused only on risk groups, is ineffective. The second study of 5 223 pregnant women is a case-control study. We find that the age of women over 30 cannot be regarded as a risk factor for thyroid disease in pregnancy, although addition this age criterion to the case-finding screening strategy improve its efficiency and ATA (American Thyroid Association) include it in their guideline 2011. The third publication is a retrospective cross-sectional study of 188...
Book chapters on the topic "Thyroid peroxidase antibodies"
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Wadeleux, P., J. Ruf, P. Carayon, and R. Winand. "Comparison of Circulating Thyroid Microsomal, Cytotoxic and Thyroid Peroxidase Antibodies." In Autoimmune Thyroiditis, 141–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76301-4_16.
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Mezösi, E., S. Szücs, S. Sárközi, E. Fórizs, and J. Szabó. "The effect of anti-microsomal antibodies on thyroid peroxidase activity." In New Aspects in Thyroid Diseases, edited by H. F. Deckart and E. Strehlau, 8–17. Berlin, Boston: De Gruyter, 1992. http://dx.doi.org/10.1515/9783110874051-003.
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Steiner, Johann, Winfried Stoecker, Bianca Teegen, Henrik Dobrowolny, Gabriela Meyer-Lotz, Katrin Borucki, Paul C. Guest, and Hans-Gert Bernstein. "Testing for Thyroid Peroxidase and Antineuronal Antibodies in and." In Methods in Molecular Biology, 203–13. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1558-4_13.
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Weber, K., and H. Schatz. "Longitudinal and Cross-Sectional Studies on Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders Compared to Conventional Anti-Microsomal Antibodies." In Autoimmune Thyroiditis, 85–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76301-4_10.
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Miller, Aaron E., Tracy M. DeAngelis, Michelle Fabian, and Ilana Katz Sand. "A SREATable Encephalopathy." In Neuroimmunology, 61–64. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190693190.003.0011.
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Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), more commonly known as Hashimoto’s encephalopathy, is a rare, poorly understood, and probably under-diagnosed disorder. SREAT is characterized by a progressive cognitive decline, with neuropsychiatric features and possible seizures, myoclonus, and tremors in association with the presence of anti-thyroid, anti-thyroid peroxidase (TPO) and/or anti-thyroglobulin (TG) antibodies. Importantly, alternative explanations for encephalopathy must be excluded. There are no specific clinical, radiographic, or EEG abnormalities. MRI brain and CSF analysis can be normal. Antithyroid antibodies, either in serum or CSF, provide the key diagnostic clue but are not clearly pathogenic. The hallmark of SREAT is an excellent therapeutic response to steroids.
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Bülow Pedersen, Inge, and Peter Laurberg. "Antibodies to Thyroid Peroxidase and Thyroglobulin in Iodine Deficiencies." In Comprehensive Handbook of Iodine, 575–85. Elsevier, 2009. http://dx.doi.org/10.1016/b978-0-12-374135-6.00060-1.
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Aulanniam, Aulanni’am, Zulkarnain Zulkarnain, Djoko Wahono Soeatmadji, Dyah Kinasih Wuragil, and Yudit Oktanella. "Thyroid Peroxidase (TPO) and Thyroid Stimulating Hormone Receptor (TSHR) Based Detection on Grave for Pregnant Women." In Graves' Disease [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96509.
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Graves’ disease is a form of specific autoimmune disorder in the thyroid organ characterized by thyroid-stimulating antibodies (TSAb). Pregnant women are the most susceptible to GD due to hormonal changes and tolerance of immune responses during pregnancy. The incidence of prematurity, low birth weight (LBW), and neonatal thyrotoxicosis risk are the most complications that can be acquired if treatment is late and inadequate. It has implications for increased fetomaternal morbidity and mortality. Apart from being a biomarker for definitive diagnosis, TSAb testing is also beneficial for assessing treatment response and predicting relapse of GD (relapse) after oral anti-thyroid treatment. GD patients with high TPOAb titers also tend to have a high relapse rate. However, the evaluation of both TSAb and TPOAb examinations during and after treatment is rarely done routinely due to the examination’s high cost. This works proposed developing TSHR and TPO antigen-based rapid diagnostic tests through the immunochromatography method to address the challenges of financing and limited laboratory facilities in the area. Besides, understanding the importance of examining thyroid antibodies (TSAb and TPOAb) and interpretation in clinical practice is still a matter of debate in clinical circles, so it requires in-depth information.
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Butler, Gary, and Jeremy Kirk. "Thyroid gland disorders." In Paediatric Endocrinology and Diabetes, 289–312. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198786337.003.0009.
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• The thyroid gland produces all of the T4 and 20% of T3. • Congenital hypothyroidism is caused by: ◦ anatomical defects: agenesis/dysgenesis, ectopic, sublingual ◦ inborn errors of thyroid hormone metabolism ◦ secondary (pituitary thyroid-stimulating hormone (TSH)) or tertiary (hypothalamic thyrotropin-releasing hormone) deficiency ◦ iodine deficiency (commonest cause worldwide of hypothyroidism, patients are usually euthyroid). • Genetic causes are rare. • In most countries worldwide, newborn TSH screening is performed at 0–5 days of age. Treatment with l-thyroxine is (usually) lifelong. • Neonatal thyrotoxicosis due to transplacental passage of thyroid-stimulating immunoglobulins (TSIs) from mothers with thyrotoxicosis/Graves’ disease and may require antithyroid drugs (ATDs). • Acquired autoimmune hypothyroidism in children and adolescents: ◦ is caused by lymphocytic infiltration of the thyroid gland (Hashimoto’s disease/thyroiditis) • raised thyroid peroxidase antibodies are diagnostic • treatment is with l-thyroxine. • Hyperthyroidism (Graves’ disease, Hashimoto’s stimulatory phase (Hashitoxicosis)): ◦ is caused by autoantibodies to the TSH receptor (TSI, or TRAbthyrotropin receptor antibody) ◦ the first-line drug of choice is the ATD carbimazole ◦ thyroidectomy or radioiodine treatment can be considered for drug-resistant cases or after relapse. • Thyroid cancer is rare in childhood and adolescence, usually presenting with a nodule, but can be part of the multiple endocrine neoplasia syndromes.
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Molnár, Ildikó. "Deiodinase Enzymes and Their Activities in Graves’ Hyperthyroidism." In Graves' Disease [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97007.
Full textAbstract:
The origin of hyperthyroidism in Graves’ disease was displayed demonstrating the complexity of the processes. The role of stimulating TSH receptor antibodies is the one factor for the production of increased thyroidal T3 and T4. The T3 and T4 formation in colloid-embedded thyroglobulin and the activities of thyroidal deiodinases [type 1 (DIO1) and type 2 (DIO2)] play a crucial role in that. The findings of different authors were summarized with respect to highlighting the role of tissue-specific deiodinase activities. Apart from the results of experimental studies, the clinical results were brought to the front. The role of tissue-specific type 2 deiodinase activity was demonstrated according to thyroid function, the presence of autoantibodies against thyroid peroxidase (TPO), thyroglobulin (Tg) and TSH receptor. Autoantibodies against human eye muscle membrane and cytosol antigens had influencing effects on tissue-specific DIO2 activities, and the antieye muscle antibody immunoglobulin isotypes were associated with eye muscle enlargements. Antithyroid drug (ATD) therapy demonstrated relevant effects on tissue-specific DIO2 activities, which were manifested in the alterations of thyroid hormone levels. An asymptomatically appearance of autoantibodies against peptides corresponding to amino acid sequence of DIO2 was detected associating with thyroid hormone and anti-TPO, anti-Tg and TSH receptor antibody levels during the therapy.
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Essam, Aref, Kai Nestler, Mostafa Taisseer, Mohamed Shabaan, and Dietrich Klingmueller. "Serum TSH and Antithyroid Peroxidase Antibodies (TPOAb) in Obese German and Kuwaiti Patients." In CLINICAL/TRANSLATIONAL - Thyroid Disease: Autoimmunity, P1–694—P1–694. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part2.p17.p1-694.
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