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Journal articles on the topic 'Tissue eosinophil'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Cantarini, L., N. Volpi, P. Carbotti, et al. "Eosinophilia-associated muscle disorders: an immunohistological study with tissue localisation of major basic protein in distinct clinicopathological forms." Journal of Clinical Pathology 62, no. 5 (2009): 442–47. http://dx.doi.org/10.1136/jcp.2008.060616.

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Aims:(a) To evaluate tissue eosinophil density, location of eosinophil cytotoxic products, histopathological muscle changes and inflammatory cell types in different eosinophilia-associated myopathies that are clinicopathologically heterogeneous. (b) To determine the immunohistological range of tissue eosinophil density in non-eosinophilic inflammatory myopathies.Methods:Muscle biopsy specimens from seven patients with blood and/or tissue eosinophilia and clinicolaboratory myopathic signs (five chronic course myopathies, one subacute onset fasciitis/myositis, one acute myositis), and from 18 no

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Desreumaux, P., A. Janin, S. Dubucquoi, et al. "Synthesis of interleukin-5 by activated eosinophils in patients with eosinophilic heart diseases." Blood 82, no. 5 (1993): 1553–60. http://dx.doi.org/10.1182/blood.v82.5.1553.1553.

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Abstract Eosinophilic endomyocardial disease represents a major evolutive risk in chronic eosinophilia-associated disorders. Eosinophil granule proteins appear to be involved in cardiac injury, but the mechanisms leading to eosinophil infiltration and degranulation are not clear. Interleukin-5 (IL-5) has been recently shown to be produced by eosinophils and might play a role in both chemoattraction and degranulation of eosinophils. In four cases of eosinophilic diseases with severe cardiac failure, we evaluated the proportion of eosinophil phenotypes and the serum levels of eosinophil cationic

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Desreumaux, P., A. Janin, S. Dubucquoi, et al. "Synthesis of interleukin-5 by activated eosinophils in patients with eosinophilic heart diseases." Blood 82, no. 5 (1993): 1553–60. http://dx.doi.org/10.1182/blood.v82.5.1553.bloodjournal8251553.

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Eosinophilic endomyocardial disease represents a major evolutive risk in chronic eosinophilia-associated disorders. Eosinophil granule proteins appear to be involved in cardiac injury, but the mechanisms leading to eosinophil infiltration and degranulation are not clear. Interleukin-5 (IL-5) has been recently shown to be produced by eosinophils and might play a role in both chemoattraction and degranulation of eosinophils. In four cases of eosinophilic diseases with severe cardiac failure, we evaluated the proportion of eosinophil phenotypes and the serum levels of eosinophil cationic protein

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Simon, H. U., S. Yousefi, C. Schranz, A. Schapowal, C. Bachert, and K. Blaser. "Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia." Journal of Immunology 158, no. 8 (1997): 3902–8. http://dx.doi.org/10.4049/jimmunol.158.8.3902.

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Abstract Nasal polyps, which often occur in association with allergic rhinitis and asthma, are characterized by a marked infiltration of eosinophils. Using a method for detecting eosinophils with DNA strand breaks, we found direct evidence for inhibition of eosinophil apoptosis in this model of tissue eosinophilia. By using Southern blot analysis linked to reverse transcription-PCR, we detected a mRNA signal specific for IL-5 in all nasal polyps. The identification of IL-5 as a major eosinophil survival factor was confirmed by ELISA measurements using tissue homogenates. Moreover, immunohistoc

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Van Hulst, Glenn, Fabrice Bureau, and Christophe J. Desmet. "Eosinophils as Drivers of Severe Eosinophilic Asthma: Endotypes or Plasticity?" International Journal of Molecular Sciences 22, no. 18 (2021): 10150. http://dx.doi.org/10.3390/ijms221810150.

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Asthma is now recognized as a heterogeneous disease, encompassing different phenotypes driven by distinct pathophysiological mechanisms called endotypes. Common phenotypes of asthma, referred to as eosinophilic asthma, are characterized by the presence of eosinophilia. Eosinophils are usually considered invariant, terminally differentiated effector cells and have become a primary therapeutic target in severe eosinophilic asthma (SEA) and other eosinophil-associated diseases (EADs). Biological treatments that target eosinophils reveal an unexpectedly complex role of eosinophils in asthma, inclu

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Radke, Amy L., Lauren E. Reynolds, Rossana C. N. Melo, Ann M. Dvorak, Peter F. Weller, and Lisa A. Spencer. "Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation." Blood 113, no. 13 (2009): 3092–101. http://dx.doi.org/10.1182/blood-2008-05-155937.

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Abstract Eosinophil chemotaxis and survival within tissues are key components in the development of tissue eosinophilia and subsequent effector responses. In this study, we demonstrate a novel mechanism of eosinophil autoregulation affecting migration and survival mediated through Notch signaling. We show for the first time that human blood eosinophils express Notch receptors and Notch ligands, expressions of which are influenced by the presence of eosinophil-activating granulocyte-macrophage colony-stimulating factor (GM-CSF). Evidence of Notch receptor activation and subsequent transcription

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Masterson, Joanne C., Calies Menard-Katcher, Leigha D. Larsen, Glenn T. Furuta, and Lisa A. Spencer. "Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies." Cells 10, no. 2 (2021): 426. http://dx.doi.org/10.3390/cells10020426.

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Eosinophils are implicated in the pathophysiology of a spectrum of eosinophil-associated diseases, including gastrointestinal eosinophilic diseases (EGIDs). Biologics that target the IL-5 pathway and are intended to ablate eosinophils have proved beneficial in severe eosinophilic asthma and may offer promise in treating some endotypes of EGIDs. However, destructive effector functions of eosinophils are only one side of the coin; eosinophils also play important roles in immune and tissue homeostasis. A growing body of data suggest tissue eosinophils represent a plastic and heterogeneous populat

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Saraiva, Ana Laura, and Fátima Carneiro. "New Insights Into the Role of Tissue Eosinophils in the Progression of Colorectal Cancer: A Literature Review." Acta Médica Portuguesa 31, no. 6 (2018): 329. http://dx.doi.org/10.20344/amp.10112.

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Introduction: Amongst the inflammatory cells implicated in the immune surveillance of colorectal cancer, a growing body of evidence suggests a role for eosinophils in carcinogenesis. We aimed to review the value of tumour-associated tissue eosinophilia (TATE) in the prognosis of colorectal cancer emphasizing the identification and measurement of tissue-infiltrating eosinophils and their association with the clinicopathological features of the disease.Material and Methods: We used PubMed and Web of Science search engines to retrieve studies that looked at the association between tissue eosinoph

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Rothenberg, Marc E., James A. MacLean, Eric Pearlman, Andrew D. Luster, and Philip Leder. "Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia." Journal of Experimental Medicine 185, no. 4 (1997): 785–90. http://dx.doi.org/10.1084/jem.185.4.785.

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The chemokines are a large group of chemotactic cytokines that regulate leukocyte trafficking and have recently been shown to inhibit human immunodeficiency virus entry into cells. Eotaxin is a C–C chemokine implicated in the recruitment of eosinophils in a variety of inflammatory disorders and, unlike all other eosinophil chemoattractants, is eosinophil specific. However, given the large number of chemoattractants that have activities on eosinophils, it is unclear whether eotaxin has an important role in vivo. Furthermore, it remains unclear why there is constitutive expression of eotaxin in

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Manohar, Murli, Alok K. Verma, Sathisha Upparahalli Venkateshaiah, and Anil Mishra. "Role of eosinophils in the initiation and progression of pancreatitis pathogenesis." American Journal of Physiology-Gastrointestinal and Liver Physiology 314, no. 2 (2018): G211—G222. http://dx.doi.org/10.1152/ajpgi.00210.2017.

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Eosinophilic pancreatitis (EP) is reported in humans; however, the etiology and role of eosinophils in EP pathogenesis are poorly understood and not well explored. Therefore, it is interesting to examine the role of eosinophils in the initiation and progression of pancreatitis pathogenesis. Accordingly, we performed anti-major basic protein immunostaining, chloroacetate esterase, and Masson’s trichrome analyses to detect eosinophils, mast cells, and collagen in the tissue sections of mouse and human pancreas. Induced eosinophils accumulation and degranulation were observed in the tissue sectio

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Kurose, Nozomu, Seiya Mizuguchi, Yoshiiku Ohkanemasa, et al. "Adenosquamous carcinoma of the uterine cervix displaying tumor-associated tissue eosinophilia." SAGE Open Medical Case Reports 7 (January 2019): 2050313X1982823. http://dx.doi.org/10.1177/2050313x19828235.

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Background: Tumor-associated tissue eosinophilia is defined as an inflammatory response with the marked infiltration of eosinophils within tumor tissues. Tumor-associated tissue eosinophilia has been reported in various organs; however, no studies have examined the detailed cytopathological findings of tumor-associated tissue eosinophilia. Case Presentation: A 49-year-old woman presented with lower abdominal and back pain that had started 1 month earlier. A cervical biopsy revealed a diagnosis of non-keratinizing squamous cell carcinoma. A mildly increased number of eosinophils was observed in

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Singh, Devender Pal, S. S. Dogra, Munish Saroch, Bal Chander, Sudesh Kumar, and Ankush Sharma. "Association between Blood Eosinophil Count and Tissue Eosinophil Grading Among Patients Suffering From Sinonasal Polyposis Attending Tertiary Care Hospital." International Academic Research Journal of Surgery 2, no. 03 (2022): 1–5. http://dx.doi.org/10.47310/iarjs.2022.v02i03.001.

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Background: Present study aimed to evaluate the association between blood eosinophil count and tissue eosinophil grading among Patients suffering from Sinonasal Polyposis attending routine ENT OPD in Dr. RPGMC Tanda. Material and Methods: The present study was done as a hospital based cross sectional study in the department of ENT and Head and Neck Surgery, in Dr. RPGMC Kangra at Tanda. It was done in 30 patients of chronic rhinosinusitis with nasal polyposis (CRSwNP) from June 2018 to June 2019 who met the inclusion criteria. Data regarding Blood and Tissue eosinophil count was retrieved. Res

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Lenz, Benjamin, Alexandra Ehrens, Jesuthas Ajendra, et al. "Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner." PLOS Pathogens 20, no. 3 (2024): e1012071. http://dx.doi.org/10.1371/journal.ppat.1012071.

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Background Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy and autoimmune disease-driven pathology is still not sufficiently understood. In this study, we established a mouse model for microfilariae-induced eosinophilic lung disease (ELD), a manifestation caused by eosinophil hyper-responsiveness within the lung. Methods Wild-type (WT) BALB/c mice were sensitized with dead microfilariae (MF) of the rodent filarial nema

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Kolobovnikova, Yu V., K. I. Yankovich, E. V. Romanova, et al. "VEGF-and EGF-mediated cooperation of eosinophilic granulocytes and tumor cells in gastric and colon cancer." Bulletin of Siberian Medicine 18, no. 1 (2019): 211–19. http://dx.doi.org/10.20538/1682-0363-2019-1-211-219.

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Aim of the research – to analyze secretion of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) by blood eosinophilic granulocytes in vitro, together with an expression of VEGFR and EGFR in tumor tissue in gastric and colon cancer in association with tissue eosinophilia.Materials and methods. A total of 52 patients with gastric cancer and 50 patients with colon cancer were examined. The material of the research included supernatants of eosinophil cultures and samples of malignant tumors tissues of the stomach and colon. Enzyme-linked immunosorbent assay was used to de

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Fan, Judy, William Daniels, Athenea Pascual, et al. "Blood IgE and Eosinophils are not Reliable Predictors of Nasal Tissue Eosinophils in Chronic Rhinosinusitis with Nasal Polyposis." International Archives of Otorhinolaryngology 29, no. 02 (2025): 001–5. https://doi.org/10.1055/s-0044-1801316.

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Abstract Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a chronic inflammatory condition of the paranasal sinuses that is mainly associated with type-2 inflammation. Immunoglobulin E (IgE) and eosinophils in blood and nasal tissue have been suggested as biomarkers for the prognosis and severity of CRSwNP as well as indications for biological treatment. Objective The present study aims to assess the relationships between blood IgE concentration, blood eosinophil count, and nasal polyp eosinophil count in CRSwNP patients. Methods The present study is retrospective. Nasal po

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Jain, Megha, Sowmya Kasetty, U. S. Sudheendra, Manisha Tijare, Samar Khan, and Ami Desai. "Assessment of Tissue Eosinophilia as a Prognosticator in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma—An Image Analysis Study." Pathology Research International 2014 (February 19, 2014): 1–6. http://dx.doi.org/10.1155/2014/507512.

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Association of tissue eosinophilia with oral squamous cell carcinoma has shown variable results ranging from favourable to unfavourable or even having no influence on prognosis. Also, very few studies have been done to know the role of eosinophils in premalignancy. So the present study investigated role of eosinophilic infiltration in oral precancer and cancer and its possible use as a prognosticator. 60 histopathologically proven cases (20 cases each of metastatic and nonmetastatic oral squamous cell carcinoma and oral leukoplakia with dysplasia of various grades) were included. Congo red is

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Kolobovnikova, Yu V., K. I. Yankovich, E. V. Romanova, A. I. Dmitrieva, V. V. Novitskiy, and O. I. Urazova. "The expression of CCL11/eotaxin, CCR3 receptor and eosinophil peroxidase in tumor tissue in gastric and colon cancers." Bulletin of Siberian Medicine 17, no. 3 (2018): 80–87. http://dx.doi.org/10.20538/1682-0363-2018-3-80-87.

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The purpose of the study was to analyze the expression of CCL11/eotaxin, CCR3 receptor to eotaxin and eosinophil peroxidase (EXP) in tumor tissue and its relation to tissue eosinophilia in gastric and colon cancers.Materials and methods. 52 patients with gastric cancer and 55 patients with colon cancer were examined. The material of the study was samples of malignant tumors of the stomach and large intestine obtained during a surgery. The expression of CCL11/eotaxin, CCR3 and EXP in the tumor tissue was evaluated by immunohistochemical method. For statistical processing of the results, one-fac

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Ganti, Ashwin, Hannah N. Kuhar, Michael Eggerstedt, et al. "The Association of Serum Eosinophilia with Structured Histopathology in Chronic Rhinosinusitis." Annals of Otology, Rhinology & Laryngology 129, no. 5 (2019): 512–16. http://dx.doi.org/10.1177/0003489419898200.

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Background: Prior studies have demonstrated associations between serum eosinophilia and chronic rhinosinusitis (CRS) pathogenesis. However, the association of serum eosinophilia with histopathology profiling in CRS has not been fully delineated and may help better characterize CRS disease burden prior to surgery. Methods: A structured histopathology report of 13 variables was utilized to analyze sinus tissue removed during functional endoscopic sinus surgery (FESS). Complete blood count (CBC) with differential was drawn within 4 weeks prior to FESS. Serum eosinophilia was defined as >6.0% (

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Mukamurera P., Nyiramana. "Role of Eosinophils in Immunity, Allergy, and Inflammation: Friend or Foe." INOSR EXPERIMENTAL SCIENCES 14, no. 1 (2024): 16–20. http://dx.doi.org/10.59298/inosres/2024/141.1620.

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Eosinophils are multifunctional granulocytes involved in both protective and pathological immune responses. Traditionally recognized for their role in host defense against parasitic infections, eosinophils have gained significant attention for their involvement in allergic diseases, such as asthma, allergic rhinitis, and atopic dermatitis, where they are often considered detrimental. Eosinophils contribute to tissue damage and inflammation by releasing cytotoxic granule proteins, cytokines, and chemokines, perpetuating chronic inflammation. In conditions such as eosinophilic gastrointestinal d

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Xu, S., M. Vallei, J. Hwang Siok Gek, C. Tze Choong, and N. Wei Yang Teo. "Endotyping of nasal polyps in a multiracial Asian population." Rhinology Online 5, no. 5 (2022): 142–48. http://dx.doi.org/10.4193/rhinol/22.026.

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Background: Chronic rhinosinusitis is a heterogenous disease with variation in the endotypes of nasal polyps, with type 2 inflammation being more prevalent in Caucasian populations whereas Chinese populations are more heterogenous. We aim to describe the variation in endotypes for patients with chronic rhinosinusitis with nasal polyposis in our unique multiracial population. Methodology: Demographic, clinical and structured histopathological data of 66 patients who underwent sinus surgery for nasal polyposis were evaluated retrospectively. Results: 54.6% had eosinophilic disease, and 45.4% had

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Santosh, UP, and Aniketh Shyamsunder Pandurangi. "Clinicopathological Correlation between Peripheral Blood Eosinophilia and Inferior Turbinate Tissue Eosinophils." An International Journal of Otorhinolaryngology Clinics 7, no. 1 (2015): 6–8. http://dx.doi.org/10.5005/aijoc-7-1-6.

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ABSTRACT Background and objectives Allergic rhinitis affects up to 20% of the general population and is one of the most common reasons for presentations to the outpatient department. We hereby present a case series which attempts to have a correlation between tissue eosinophilia (inferior turbinate) and increased eosinophil count in blood (>440 cells/mm3). Materials and methods Thirty-six patients presented to the Outpatient Department of Bapuji Hospital and Chigateri General Hospital (Teaching Hospitals attached to JJM Medical College), Davangere, with nasal obstruction and symptoms sugges

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Santosh, UP, and Aniketh Shyamsunder Pandurangi. "Clinicopathological Correlation between Peripheral Blood Eosinophilia and Inferior Turbinate Tissue Eosinophils." An International Journal of Otorhinolaryngology Clinics 6, no. 2 (2014): 58–60. http://dx.doi.org/10.5005/jp-journals-10003-1153.

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ABSTRACT Background and objectives Allergic rhinitis affects up to 20% of the general population and is one of the most common reasons for presentations to the outpatient department. We hereby present a case series which attempts to have a correlation between tissue eosinophilia (inferior turbinate) and increased eosinophil count in blood (> 440 cells/mm3). Materials and methods Thirty-six patients presented to the Outpatient Department of Bapuji Hospital and Chigateri General Hospital (Teaching Hospitals attached to JJM Medical College), Davangere, with nasal obstruction and symptoms sugge

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Gitomer, Sarah A., Cynthia R. Fountain, Todd T. Kingdom, et al. "Clinical Examination of Tissue Eosinophilia in Patients with Chronic Rhinosinusitis and Nasal Polyposis." Otolaryngology–Head and Neck Surgery 155, no. 1 (2016): 173–78. http://dx.doi.org/10.1177/0194599816637856.

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Objective (1) Describe clinical and histopathologic findings in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). (2) Determine if tissue and serum eosinophilia predicts disease severity in CRSwNP. Study Design Case series with chart review. Setting Academic hospital specializing in respiratory and allergic disease. Subjects Patients with CRSwNP treated from 2008 to 2010. Methods Clinical data were collected; sinus computed tomography (CT) scans were scored according to the Lund-Mackay system; and surgical specimens were evaluated for degree of tissue eosinophilia. Statistical a

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Fettrelet, Timothée, Aref Hosseini, Jacqueline Wyss, et al. "Evidence for a Role of the Long Non-Coding RNA ITGB2-AS1 in Eosinophil Differentiation and Functions." Cells 13, no. 23 (2024): 1936. http://dx.doi.org/10.3390/cells13231936.

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Eosinophils, a type of granulocyte derived from myeloid precursors in the bone marrow, are distinguished by their cytoplasmic granules. They play crucial roles in immunoregulation, tissue homeostasis, and host defense, while also contributing to the pathogenesis of various inflammatory diseases. Although long non-coding RNAs (lncRNAs) are known to be involved in eosinophilic conditions, their specific expression and functions within eosinophils have not been thoroughly investigated, largely due to the reliance on tissue homogenates. In an effort to address this gap, we analyzed publicly availa

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Fischer, Thomas J., Cynthia Daugherty, Colette Gushurst, Gail M. Kephart, and Gerald J. Gleich. "Systemic Vasculitis Associated With Eosinophilia and Marked Degranulation of Tissue Eosinophils." Pediatrics 82, no. 1 (1988): 69–75. http://dx.doi.org/10.1542/peds.82.1.69.

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A 9-year-old girl had fever, life-threatening interstitial pneumonia, a vesicular skin rash, parotid and submandibular swelling, and marked blood eosinophilia (WBC count 47,000/µL, 39% eosinophils). Results of lung and skin biopsies showed vasculitis with intense eosinophil infiltration. Immunofluorescence analyses of these biopsies, as well as analysis of tissue from the parotid, lip, and trachea, showed striking deposition of eosinophil granule major basic protein associated with areas of tissue damage. Treatment with glucocorticoids and hydroxyurea produced clinical improvement. The associa

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Pritam, Pulak, Sanjeet Manna, Abhishek Sahu, et al. "Eosinophil: A central player in modulating pathological complexity in asthma." Allergologia et Immunopathologia 49, no. 2 (2021): 191–207. http://dx.doi.org/10.15586/aei.v49i2.50.

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Eosinophils are the major inflammatory cells which play a crucial role in the development of allergic and non-allergic asthma phenotypes. Eosinophilic asthma is the most heterogeneous phenotype where activated eosinophils are reported to be significantly associated with asthma severity. Activated eosinophils display an array of cell adhesion molecules that not only act as an activation marker, suitable for assessing severity, but also secrete several tissue factors, cytokines and chemokines which modulate the clinical severity. Eosinophil activations are also strictly associated with activatio

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Memis, Bahar, Burcu Saka, Juan Carlos Roa, et al. "Eosinophilic Cholecystitis and Eosinophils in Gallbladder Injuries: A Clinicopathological Analysis of 1050 Cholecystectomies." Diagnostics 13, no. 15 (2023): 2559. http://dx.doi.org/10.3390/diagnostics13152559.

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“Eosinophilic cholecystitis” has been an elusive concept. Around 1050 consecutive cholecystectomies with chronic (CC, n = 895), subacute (SAC, n = 100), and acute cholecystitis (AC, n = 55) were reviewed for eosinophilic infiltration. Eosinophilic hot spots (>40 eosinophils/HPF) were seen in 63% of SAC and 35% of AC (vs. 6% of CC, p < 0.001). Eosinophils were mostly encountered in areas of wall thickening, revealing edema with early collagenization and young tissue-culture-type fibroblasts. However, in ten chronic cholecystitis patients (<1%), prominent eosinophilia with eosinophil-ri

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Salter, Brittany M., Xiaotian Ju, and Roma Sehmi. "Eosinophil Lineage-Committed Progenitors as a Therapeutic Target for Asthma." Cells 10, no. 2 (2021): 412. http://dx.doi.org/10.3390/cells10020412.

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Eosinophilic asthma is the most prevalent phenotype of asthma. Although most asthmatics are adequately controlled by corticosteroid therapy, a subset (5–10%) remain uncontrolled with significant therapy-related side effects. This indicates the need for a consideration of alternative treatment strategies that target airway eosinophilia with corticosteroid-sparing benefits. A growing body of evidence shows that a balance between systemic differentiation and local tissue eosinophilopoietic processes driven by traffic and lung homing of bone marrow-derived hemopoietic progenitor cells (HPCs) are i

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Jogdand, Prajakta, Premkumar Siddhuraj, Michiko Mori, et al. "Eosinophils, basophils and type 2 immune microenvironments in COPD-affected lung tissue." European Respiratory Journal 55, no. 5 (2020): 1900110. http://dx.doi.org/10.1183/13993003.00110-2019.

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Although elevated blood or sputum eosinophils are present in many patients with COPD, uncertainties remain regarding the anatomical distribution pattern of lung-infiltrating eosinophils. Basophils have remained virtually unexplored in COPD. This study mapped tissue-infiltrating eosinophils, basophils and eosinophil-promoting immune mechanisms in COPD-affected lungs.Surgical lung tissue and biopsies from major anatomical compartments were obtained from COPD patients with severity grades Global Initiative for Chronic Obstructive Lung Disease stages I–IV; never-smokers/smokers served as controls.

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Matsuyama, Wataru, Hideo Mitsuyama, Mikiko Ono та ін. "Discoidin domain receptor 1 contributes to eosinophil survival in an NF-κB–dependent manner in Churg-Strauss syndrome". Blood 109, № 1 (2006): 22–30. http://dx.doi.org/10.1182/blood-2006-04-015206.

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Abstract Churg-Strauss syndrome (CSS) is a systemic disease that shows marked eosinophilia along with eosinophil infiltration in the tissue. Prolonged eosinophil survival plays an important role in the pathogenesis of CSS; however, its detailed molecular mechanism remains unclear. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase, and its ligand is collagen. DDR1 was expressed in human leukocytes and fibroblasts, and it plays an important role in leukocyte cytokine production and fibroblast survival in an NF-κB–dependent manner. In this study, we examined in vitro and in vivo eo

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Baziaa, Sarra, Adil Zegmout, Ismail Abderrahmane Rhorfi, and Hanane El Ouazzani. "Diagnostic Approach To Eosinophilic Lung Disease In A Young Male Patient." IOSR Journal of Dental and Medical Sciences 23, no. 10 (2024): 48–51. http://dx.doi.org/10.9790/0853-2310014851.

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Eosinophilic lung diseases are a varied group of disorders that, apart from the presence of eosinophils, often have little in common clinically. Chronic eosinophilic pneumonia (CEP) is thought to represent 1-3% of interstitial lung diseases and is characterized by significant eosinophilia in both tissue and peripheral blood. We present the case of a 21-year-old patient, non-smoking and with no history of atopy. He came in with progressively worsening, insidious respiratory symptoms, reporting cough and dyspnea. The diagnosis of chronic eosinophilic pneumonia was considered based on characteris

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Ackerman, S. J., G. M. Kephart, H. Francis, K. Awadzi, G. J. Gleich, and E. A. Ottesen. "Eosinophil degranulation. An immunologic determinant in the pathogenesis of the Mazzotti reaction in human onchocerciasis." Journal of Immunology 144, no. 10 (1990): 3961–69. http://dx.doi.org/10.4049/jimmunol.144.10.3961.

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Abstract Onchocerciasis patients treated with diethylcarbamazine often undergo a severe inflammatory response, the Mazzotti reaction. To assess the eosinophil's role in the pathogenesis of the Mazzotti reaction, we obtained serial blood, plasma, and skin biopsy specimens from 21 heavily infected patients and 3 endemic controls, both before and during therapy with diethylcarbamazine. Samples were analyzed for blood eosinophils, plasma levels of eosinophil granule major basic protein (MBP) and eosinophil-derived neurotoxin, eosinophil infiltration and eosinophil and mast cell degranulation in th

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Dibbert, Birgit, Isabelle Daigle, Doris Braun, et al. "Role for Bcl-xL in Delayed Eosinophil Apoptosis Mediated by Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-5." Blood 92, no. 3 (1998): 778–83. http://dx.doi.org/10.1182/blood.v92.3.778.

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Abstract Eosinophils are potent inflammatory cells involved in allergic reactions. Inhibition of apoptosis of purified eosinophils by certain cytokines has been previously shown to be an important mechanism causing tissue eosinophilia. To elucidate the role of Bcl-2 family members in the inhibition of eosinophil apoptosis, we examined the expression of the known anti-apoptotic genes Bcl-2, Bcl-xL, and A1, as well as Bax and Bcl-xS, which promote apoptosis in other systems. We show herein that freshly isolated human eosinophils express significant amounts of Bcl-xL and Bax, but only little or n

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Dibbert, Birgit, Isabelle Daigle, Doris Braun, et al. "Role for Bcl-xL in Delayed Eosinophil Apoptosis Mediated by Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-5." Blood 92, no. 3 (1998): 778–83. http://dx.doi.org/10.1182/blood.v92.3.778.415k38_778_783.

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Eosinophils are potent inflammatory cells involved in allergic reactions. Inhibition of apoptosis of purified eosinophils by certain cytokines has been previously shown to be an important mechanism causing tissue eosinophilia. To elucidate the role of Bcl-2 family members in the inhibition of eosinophil apoptosis, we examined the expression of the known anti-apoptotic genes Bcl-2, Bcl-xL, and A1, as well as Bax and Bcl-xS, which promote apoptosis in other systems. We show herein that freshly isolated human eosinophils express significant amounts of Bcl-xL and Bax, but only little or no Bcl-2,

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Armengot, Miguel, Luis Garín, and Carmen Carda. "Eosinophil Degranulation Patterns in Nasal Polyposis: An Ultrastructural Study." American Journal of Rhinology & Allergy 23, no. 5 (2009): 466–70. http://dx.doi.org/10.2500/ajra.2009.23.3357.

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Background Eosinophils are possibly the most important inflammatory cells in the pathogenesis of rhinosinusitis with nasal polyposis. Eosinophil degranulation is the mechanism by which these cells exert their inflammatory action. Knowledge of eosinophil state and degranulation mode therefore may help us to better understand this disease. A study is made of eosinophil state and degranulation mode using transmission electron microscopy (TEM), attempting to establish correlations with certain clinical variables considered to be of importance in patients with nasal polyposis. Methods A prospective

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Driss, Virginie, Fanny Legrand, Emmanuel Hermann та ін. "TLR2-dependent eosinophil interactions with mycobacteria: role of α-defensins". Blood 113, № 14 (2009): 3235–44. http://dx.doi.org/10.1182/blood-2008-07-166595.

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AbstractPeripheral blood and tissue eosinophilia are a prominent feature in allergic diseases and during helminth infections. Eosinophil recruitment also frequently occurs upon mycobacterial infections, particularly in lung granuloma. However, the mechanism by which eosinophils interact with mycobacteria remains largely unknown. Because eosinophils recently have been shown to be involved in innate immune responses, we investigated the direct interactions of eosinophils with Mycobacterium bovis BCG as a study model. We show that live BCG attracts human eosinophils and induces reactive oxygen sp

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Artham, Sandeep, Aditi Goyal, Jovita Byemerwa, Ching-Yi Chang, and Donald Patrick Mcdonnell. "Abstract B02: Estrogens regulate tumor associated tissue eosinophilia to promote tumor growth." Cancer Immunology Research 10, no. 12_Supplement (2022): B02. http://dx.doi.org/10.1158/2326-6074.tumimm22-b02.

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Abstract Increased tumor associated tissue eosinophilia (TATE) is associated with better prognosis in colorectal cancers, melanoma, and prostate cancer, however, the mechanisms which regulate TATE and how it impacts tumor biology remain largely unexplored. Eosinophils within tumors have been shown to secrete cytotoxic granular contents that induce necrosis and lead to the recruitment of other immune cells which together inhibit tumor growth. Interestingly, estrogens have been shown to increase eosinophilia in several disease settings although it has not been established if and how estrogens im

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Sturm, Eva Maria, Eva Knuplez, and Gunther Marsche. "Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases." International Journal of Molecular Sciences 22, no. 9 (2021): 4377. http://dx.doi.org/10.3390/ijms22094377.

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Eosinophils are key components of our host defense and potent effectors in allergic and inflammatory diseases. Once recruited to the inflammatory site, eosinophils release their cytotoxic granule proteins as well as cytokines and lipid mediators, contributing to parasite clearance but also to exacerbation of inflammation and tissue damage. However, eosinophils have recently been shown to play an important homeostatic role in different tissues under steady state. Despite the tremendous progress in the treatment of eosinophilic disorders with the implementation of biologics, there is an unmet ne

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Lamas, A. M., C. M. Mulroney, and R. P. Schleimer. "Studies on the adhesive interaction between purified human eosinophils and cultured vascular endothelial cells." Journal of Immunology 140, no. 5 (1988): 1500–1505. http://dx.doi.org/10.4049/jimmunol.140.5.1500.

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Abstract Many recent studies have established the eosinophil as a primary effector cell in the pathology of allergic diseases. However, relatively little is known about the mechanisms by which eosinophils accumulate and are activated at local sites of tissue inflammation in allergic or other eosinophil-dependent pathologic states. Because the adherence of leukocytes to vascular endothelial cells (VEC) is a critical initial event in eosinophil infiltration, we have studied the interaction of purified human eosinophils with cultured human umbilical vein endothelial cells. Treatment of VEC with s

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Liu, Wenlong, Qingxiang Zeng, Yanqiu Chen, and Ren Zhong Luo. "Role of Leptin/Osteopontin Axis in the Function of Eosinophils in Allergic Rhinitis with Obesity." Mediators of Inflammation 2018 (October 24, 2018): 1–10. http://dx.doi.org/10.1155/2018/9138904.

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Background. Allergic rhinitis (AR) is characterized by tissue and blood eosinophilia. Previous studies showed enhanced eosinophilia in allergic rhinitis patients with obesity, suggesting an association between obesity and eosinophilia. However, the interaction and mechanism between obesity and eosinophilia is still unclear. Methods. We recruited thirty AR children and 30 controls in this study. Expression of leptin and osteopontin (OPN) proteins in serum was detected, and correlation analysis with eosinophilia was performed. The effect of leptin or OPN on eosinophil apoptosis, adhesion, migrat

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Jackson, David J., Praveen Akuthota, and Florence Roufosse. "Eosinophils and eosinophilic immune dysfunction in health and disease." European Respiratory Review 31, no. 163 (2022): 210150. http://dx.doi.org/10.1183/16000617.0150-2021.

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The functions ascribed to eosinophils have classically been limited to host defence against certain parasitic infections and potentially deleterious effects in the setting of specific diseases that are associated with elevated eosinophil counts in blood and/or tissue. The ability to induce eosinophil depletion either experimentally in animal models or through targeted therapies in humans has extended our understanding of the roles played by eosinophils in health and homeostasis as well as in disease pathogenesis. When associated with human disease aetiology, the eosinophil takes on a pathogeni

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Mwanthi, Muithi, Gracie Michels, Karl Staser, et al. "PAK1 Regulates Eotaxin-Mediated Murine Eosinophil Migration in Vitro and In Vivo." Blood 118, no. 21 (2011): 18. http://dx.doi.org/10.1182/blood.v118.21.18.18.

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Abstract Abstract 18 Eosinophils are increasingly recognized as important myeloid effector cells in the inflammatory environment of many human diseases. Although eosinophils critically contribute to chronic asthmatic inflammation, few therapies directly target these cells. Eosinophils rapidly migrate to eotaxin elicited by allergic sensitization and challenge, a chemokine that ligates the CCR3 receptor. Eotaxin:CCR3 signaling critically regulates allergen-induced eosinophil infiltration in murine models by activating the Rho-family proteins. In several cell systems, the Rho proteins Rac and CD

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Kuang, Fei Li. "Dexpramipexole: A Potential Non-biologic Alternative for Patients with Eosinophilic Asthma?" US Respiratory & Pulmonary Diseases 7, no. 2 (2022): 36. http://dx.doi.org/10.17925/usrpd.2022.7.2.36.

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Dexpramipexole offers a potential non-biologic option for patients with eosinophilic asthma in that it lowers blood eosinophil count and improves lung function parameters. However, longer-term studies in patients treated by reducing blood or tissue eosinophils, whether through biologics or oral therapies, are needed to better understand the role of the eosinophil in human biology and disease pathogenesis and to better delineate the clinical efficacy of Dexpramizole in asthma.

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Doan, Ton C., Brian M. Jeong, Mackenzie Coden, Hiam Abdala-Valencia, and Sergejs Berdnikovs. "Matrix protein Tenascin-C expands and reversibly blocks maturation of eosinophil progenitors." Journal of Immunology 200, no. 1_Supplement (2018): 103.9. http://dx.doi.org/10.4049/jimmunol.200.supp.103.9.

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Abstract While eosinophil depletion is a sought after strategy in treating allergic disease, little is known about the local tissue factors regulating eosinophils. In disease, eosinophils encounter provisional extracellular matrix (ECM) glycoproteins such as Tenascin-C (TNC), which strongly correlates with eosinophil expansion in tissues. While restricted in healthy adult lungs, TNC is a hematopoietic niche component in bone marrow stroma and is expressed de novo during wound healing or in pathologic epithelial remodeling in asthma. RNA-Seq shows that exposing naïve murine eosinophils to TNC u

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Humbles, Alison A., Dolores M. Conroy, Sylvie Marleau, et al. "Kinetics of Eotaxin Generation and Its Relationship to Eosinophil Accumulation in Allergic Airways Disease: Analysis in a Guinea Pig Model In Vivo." Journal of Experimental Medicine 186, no. 4 (1997): 601–12. http://dx.doi.org/10.1084/jem.186.4.601.

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Challenge of the airways of sensitized guinea pigs with aerosolized ovalbumin resulted in an early phase of microvascular protein leakage and a delayed phase of eosinophil accumulation in the airway lumen, as measured using bronchoalveolar lavage (BAL). Immunoreactive eotaxin levels rose in airway tissue and BAL fluid to a peak at 6 h falling to low levels by 12 h. Eosinophil numbers in the tissue correlated with eotaxin levels until 6 h but eosinophils persisted until the last measurement time point at 24 h. In contrast, few eosinophils appeared in BAL over the first 12 h, major trafficking t

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Badewa, A. P., C. E. Hudson, and A. S. Heiman. "Regulatory Effects of Eotaxin, Eotaxin-2, and Eotaxin-3 on Eosinophil Degranulation and Superoxide Anion Generation1." Experimental Biology and Medicine 227, no. 8 (2002): 645–51. http://dx.doi.org/10.1177/153537020222700814.

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Eosinophilic leukocytes have been implicated as primary effector cells in inflammatory and allergic diseases. When activated by cytokines, human eosinophils secrete and produce a variety of proinflammatory or tissue damaging substances. Although well known for their chemoattractant effects, little is known about the precise contribution of the eosinophil-selective chemokines, eotaxin, eotaxin-2, and eotaxin-3 to the effector functions of eosinophils. This forms the central focus of these investigations for which clone 15-HL-60 human eosinophilic cells were used as the in vitro model. Investiga

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Nilam More, Amita Joshi, Snehal Jumnake, and Pallavi Gulhane. "A study of eosinophil count in oesophageal and gastric mucosal biopsies at a tertiary care centre." Journal of Pathology of Nepal 13, no. 2 (2023): 2053–58. http://dx.doi.org/10.3126/jpn.v13i2.46929.

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Background: Eosinophils are inflammatory cells that can infiltrate several organs playing a major role in causing tissue damage and organ dysfunction. This study was conducted to establish the baseline eosinophil count in normal states and to correlate mucosal eosinophil count with abnormalities of the oesophagus and stomach. Materials and methods: A retrospective observational study was conducted at the surgical pathology department of a tertiary care hospital in Mumbai. A total of 124 biopsies were studied. Oesophageal and stomach biopsies with some pathology including oesophagitis, gastriti

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Sung, Sun-sang Joseph, Joanne A. Lannigan, and C. Edward Rose. "Lung eosinophils homing in homeostasis (98.2)." Journal of Immunology 178, no. 1_Supplement (2007): S192. http://dx.doi.org/10.4049/jimmunol.178.supp.98.2.

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Abstract Severe lung eosinophilia is a significant feature of the inflammatory response in asthma. Besides producing various secretory products that mediate tissue injury and leukocyte activation, eosinophils from inflamed tissues have been shown to present antigens to T cells. However, the phenotype and function of eosinophils in normal tissues is poorly characterized and their antigen presentation capacity controversial. With magnetic microbead selection against the major eosinophil markers, eosinophils from normal lung tissues have been enriched to 50% of the selected cells. Surface marker

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Tsarev, Sergey V. "Eosinophilic pneumonia in allergological practice." Russian Journal of Allergy 18, no. 1 (2021): 32–40. http://dx.doi.org/10.36691/rja1413.

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In this article, current data on pulmonary eosinophilia are presented. Pulmonary eosinophilia is defined as the infiltration of eosinophils into the airways, interstitia, and alveoli. There are diverse processes in etiology, the common feature of which is the presence of pulmonary eosinophilic infiltrates, and as a rule, peripheral blood eosinophilia. Causes of pulmonary eosinophilia include various infections, medications, parasites, autoimmune processes, malignancies, and presence of obstructive pulmonary diseases. A unified classification of pulmonary eosinophilia is lacking, and instead, v

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Dubucquoi, S., P. Desreumaux, A. Janin, et al. "Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion." Journal of Experimental Medicine 179, no. 2 (1994): 703–8. http://dx.doi.org/10.1084/jem.179.2.703.

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Interleukin 5 (IL-5) is the main factor that promotes the terminal differentiation of eosinophil progenitors (as indicated by colony formation assays), and enhances the effector capacity of mature eosinophils. IL-5 is produced by T lymphocytes, CD4-/CD8- and mast cells and recently, messenger (m)RNA of this cytokine has been identified in eosinophils from patients with coeliac disease, asthma, or eosinophilic heart diseases. In this study, IL-5 mRNA and immunoreactive IL-5 protein were detected in tissue and blood eosinophils from patients with eosinophilic cystitis or hypereosinophilic syndro

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