Relevant bibliographies by topics / Total bilirubin

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Total bilirubin'

Author: Grafiati
Published: 4 June 2025
Last updated: 15 July 2025

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Journal articles on the topic "Total bilirubin"

1

Ball, Matthew, Irene Miller, and Steven W. Cotten. "Direct Bilirubin Higher Than Total Bilirubin?" Clinical Chemistry 61, no. 6 (2015): 889. http://dx.doi.org/10.1373/clinchem.2014.237040.

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Rosenthal, P., M. T. Keefe, D. Henton, et al. "Total and direct-reacting bilirubin values by automated methods compared with liquid chromatography and with manual methods for determining delta bilirubin." Clinical Chemistry 36, no. 5 (1990): 788–91. http://dx.doi.org/10.1093/clinchem/36.5.788.

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Abstract This study compares total and direct-reacting bilirubin values in 40 serum samples from patients with various diagnoses, as measured by automated methods (Beckman Synchron CX-5, Beckman Astra 8, Kodak Ektachem 700) and HPLC and by a manual method for delta bilirubin. For total bilirubin, within-run CVs were less than 6%. The Ektachem 700 method underestimated bilirubin with serum samples from patients with Crigler-Najjar syndrome and from newborns in whom unconjugated bilirubin concentrations were increased but conjugated bilirubins were not present or were present only in small amounts. The Astra 8 and Synchron CX-5 methods were inaccurate with cholestatic serum samples, in which conjugated bilirubin concentrations were increased and other compounds such as bile acids could be expected to interfere. We conclude that each automated method examined provides reasonable estimates for total and direct-reacting bilirubin values for routine clinical use. The need for each laboratory to select the appropriate bilirubin method for its particular situation is obvious.
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Rothuizen, Jan, and Ted van den Ingh. "Covalently protein-bound bilirubin conjugates in cholestatic disease of dogs." American Journal of Veterinary Research 49, no. 5 (1988): 702–4. https://doi.org/10.2460/ajvr.1988.49.05.702.

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SUMMARY We investigated the occurrence of covalently protein-bound bilirubins in the plasma of dogs with hyperbilirubinemia attributable to hepatobiliary diseases or Coombs test-positive hemolysis. The bilirubins in plasma were measured with the conventional Van den Bergh reaction, by treatment with diazotized p-iodoaniline, and by high-performance liquid chromatography of bilirubin and its methylesters after alkaline methanolysis. All but one dog had covalently protein-bound bilirubin conjugates. The concentration and the fraction of total bilirubins varied in all diseases investigated, but they tended to be low in primary hemolysis. The “biliprotein” complex accounted for 2 to 94% of total plasma bilirubins. Because biliprotein usually is not cleared by the liver, but has a half-life comparable with that of albumin, it prevents the evaluation of the actual state of the underlying disease. Measurement of the total bilirubin concentration exclusively with the Van den Bergh reaction, therefore, is clinically useless. Other methods should be introduced for routine bilirubin assays, permitting the measurement of noncovalently bound pigment as a meaningful estimate of the course of the disease.
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Manasa, D. R., H. M. Lokesh, B. Yadgude Ramkrishna, et al. "Analyzing the Stability of Stored Serum of Different Biochemical Parameters on Different Days." International Journal of Pharmaceutical and Clinical Research 16, no. 12 (2024): 221–25. https://doi.org/10.5281/zenodo.14591874.

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<strong>Background:</strong>&nbsp;Sample repository is noteworthy, especially in cases of many scientific &amp; medical processes that expedite diagnosis &amp; treatment design. Furthermore, to know the sample integrity which can impact on providing accurate or reproducible data.&nbsp;<strong>Materials &amp; Methods:</strong>&nbsp;A, total of 11 biochemical parameters were gauged by taking 13 patients&rsquo; serum samples at Chikkamagaluru Institute of Medical Sciences, Chikkamagaluru. Each patient&rsquo;s serum was stowed in an aliquot at -20<sup>&omicron;</sup>C for a month. Initial analysis (T0d) results obtained as fresh samples were compared to subsequent analysis on the 15<sup>th</sup>&nbsp;(T15d) and 30<sup>th&nbsp;</sup>(T30d) day of the month.&nbsp;<strong>Results:</strong>&nbsp;Parameters like glucose, urea, creatinine, uric acid, total bilirubin, AST, ALT, ALP, and albumin expect total protein showed stability at 15 days of analysis. Whereas serum stability was lost for total bilirubin, total protein, direct bilirubin, and ALT during the 30<sup>th</sup>&nbsp;day of analysis which was statistically significant (p&lt;0.05)&nbsp;<strong>Conclusion:</strong>&nbsp;Thus, our study shows that parameters like glucose, urea, creatinine, uric acid, albumin, AST, and ALP have shown reproducible values indicating that stability has been maintained when it was stored for up to 30 days. Total protein, bilirubin, direct bilirubin, and ALT are not preferable for analysis, thus affecting the sample integrity. &nbsp; &nbsp;
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He, Yujian, Jingjing Zhu, Fei Xiao, et al. "Association of Different Total Bilirubin Levels with Prognosis of Peritoneal Dialysis-Associated Peritonitis." Medicina 59, no. 10 (2023): 1837. http://dx.doi.org/10.3390/medicina59101837.

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Background and Objectives: Peritoneal dialysis-associated peritonitis (PDAP) poses significant challenges in peritoneal dialysis (PD) patient management and outcomes. Total bilirubin has gained attention due to its antioxidant and immunomodulatory properties. However, its relationship with PDAP prognosis remains underexplored. Materials and Methods: We conducted a retrospective single-center study involving 243 PDAP patients stratified into tertile-based groups according to total bilirubin levels. The association between total bilirubin levels and treatment failure risk was investigated through statistical analyses and restricted cubic spline curve analysis. Results: Our analysis revealed a non-linear correlation between total bilirubin levels and PDAP treatment failure risk. At total bilirubin levels below 8.24 µmol/L, a protective effect was observed, while levels exceeding this threshold heightened the risk of treatment failure. Conclusions: This study unveils a dual role of total bilirubin in PDAP prognosis. Below a certain threshold, it confers protection, while higher levels exacerbate the risk of treatment failure. These findings emphasize the need for further investigation in larger, multicenter prospective studies to validate and elucidate the mechanisms behind bilirubin’s impact on PDAP, potentially guiding the development of targeted therapeutic strategies.
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Langbaum, M. E., S. J. Farber, and P. Rosenthal. "Automated Total and Neonatal Bilirubin Values in Newborns: Is a Distinction Clinically Relevant?" Clinical Chemistry 38, no. 9 (1992): 1690–93. http://dx.doi.org/10.1093/clinchem/38.9.1690.

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Abstract Guidelines for managing hyperbilirubinemia in newborns were developed by using diazo methods that measure total and direct-reacting bilirubins and calculate an indirect fraction. The automated Kodak Ektachem system allows for measuring serum bilirubin by either of two dry-slide methods: TBIL, involving a modified diazo method, and NBIL, involving a dual-wavelength colorimetric method that fractionates and directly measures the unconjugated (Bu) and conjugated (Bc) bilirubins (Bu+Bc = neonatal bilirubin). The manufacturer recommends that NBIL be used in newborns less than 15 days old, which is impractical in a large, busy hospital laboratory. We compared NBIL and TBIL in 500 paired serum samples from infants less than 15 days old. We noted a statistically significant difference between TBIL and NBIL values (162.9, SD 70.4, vs 164.6, SD 69.2, mumol/L; P less than 0.0001), which was small and of no clinical significance. We conclude that TBIL values may be used with caution for newborn bilirubin screening. Furthermore, NBIL measurements are an acceptable alternative to diazo measurements for neonatal care, allowing the use of previously developed guidelines with NBIL values.
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Sarmin, Sarmin, Pudji Astuti, Claude Mona Airin, and Nur Adianto. "Profil Total Bilirubin, Aktivitas Alanine Transaminase danTotal Protein Domba Garut pada Umur danStatus Fisiologis yang Berbeda." Jurnal Veteriner 23, no. 3 (2022): 433–40. http://dx.doi.org/10.19087/jveteriner.2022.23.3.432.

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Tujuan peneltiian ini adalah mengkaji profil total bilirubin, aktivitas ALT, dan total protein domba garut pada umur dan status fisiologis yang berbeda. Sebanyak 36 ekor domba garut dengan berbagai kondisi fisiologis (domba betina, domba jantan, anak domba betina, anak domba jantan, anak domba lepas sapih betina, anak domba lepas sapih jantan, domba jantan muda umur enam bulan, domba jantan muda umur satu tahun, domba bunting dan domba laktasi) digunakan dalam peneltian ini. Sampel darah diambil melalui vena jugularis pada pagi hari sebelum domba diberi pakan., selanjutnya dianalisis nilai total bilirubin, aktivitas alanine aminotransferase (ALT) dan total protein. Nilai rata-rata total bilirubin domba garut adalah 0,59 ± 0,49 mg/dL, dipengaruhi oleh umur dan tidak dipengaruhi oleh jenis kelamin dan sttatus fisiologis. Nilai total bilirubin anak domba betina paling tinggi (1,85±0,87mg/dL) dibandingkan nilai total bilirubin pada umur yang lain. Nilai rata-rata aktivitas ALT domba garut adalah 18,84±6,56 U/L, dipengaruhi oleh umur tetapi tidak dipengaruhi oleh status fisiologi dan jenis kelamin. Nilai aktivitas ALT anak betina paling rendah (7,03±0,81 U/L) dibandingkan aktivitas ALT pada umur yang lain. Rata-rata total protein domba garut adalah 6,48±0,83 (g/dl), dipengaruhi oleh umur tetapi tidak dipengaruhi oleh jenis kelamin dan status fisiologi. Total protein paling rendah ditemukan pada anak betina (5,51±0,59 g/dL) dibandingkan nilai total protein pada umur lain. Disimpulkan bahwa umur berefek pada nilai total bilirubin, aktivitas ALT dan total protein domba garut. Dengan demikian, maka interpretasi nilai total bilirubin, aktivitas ALT dan total bilirubin domba garut perlu memperhatikan faktor umur.
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Sofyanita, Eko Naning, Endang Susilowaty, and Roni Afriansya. "The Effect of Light Exposure to Bilirubine Levels on Serum Jaundice Infant in Hospital of Islamic NU Demak." Borneo Journal of Medical Laboratory Technology 3, no. 1 (2020): 168–71. http://dx.doi.org/10.33084/bjmlt.v3i1.1766.

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Bilirubin is a substance formed from the normal breakdown of erythrocytes in the body so that it gives a yellow color to the stool and urine. The test of bilirubin in the laboratory must avoid exposure to light, which can cause decreased serum bilirubin levels by up to 50% in 1 hour due to disruption of the bilirubin's stability. This study is a cross-sectional analytic study of primary data using 30 samples of jaundice baby serum and direct and total bilirubin test. Data collection was conducted from the primary data by a direct test using 40 samples of infant jaundice and test of direct bilirubin and total bilirubin using methods Dichlorophenyl Diazonium. The results of the tests of 40 samples can result in the mean levels of total bilirubin were exposed to the light of 8.58 mg/dl and were not exposed to light 12,67mg /dl. Direct bilirubin levels mean that exposure to light is 3.98 mg/dl. In contrast, the unexposed light of 8.71 mg/dl, so that it can be concluded that the levels of total and direct bilirubin in serum jaundice infants exposed to lower light compared with those not exposed to light.
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Perry, B., B. T. Doumas, G. Buffone, M. Glick, C. N. Ou, and K. Ryder. "Measurement of total bilirubin by use of bilirubin oxidase." Clinical Chemistry 32, no. 2 (1986): 329–32. http://dx.doi.org/10.1093/clinchem/32.2.329.

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Abstract We used an enzymatic method for measuring total bilirubin in serum. Results by this method varied linearly with bilirubin concentrations to at least 300 mg/L. The day-to-day precision (CV) of the method ranged from less than 1% to about 11% at bilirubin concentrations of 183 and 12 mg/L, respectively. Commonly used anticoagulants, serum preparation materials, and selected drugs had no effect on the apparent bilirubin concentration, but turbidity caused a slight increase and hemoglobin concentrations of 2 g/L resulted in lower values, by as much as 17 mg/L at a bilirubin concentration of 95 mg/L. Patients' results obtained with this enzymatic method were slightly lower than those obtained with methods based on the Jendrassik-Grof principle. The largest differences, seen in samples with high "direct" bilirubin concentrations, can be decreased by measuring the absorbance at 425 nm instead of at 465 nm as recommended by the supplier of the bilirubin oxidase method.
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Turnell, D. C. "The Calibration of Total Serum Bilirubin Assays." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 22, no. 3 (1985): 217–21. http://dx.doi.org/10.1177/000456328502200301.

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Bilirubin assays yield variable results due to the lack of a universal calibrant. The preparation of a bilirubin calibrant is associated with the following problems: (a) only unconjugated bilirubin is available in a ‘pure’ form and this is of doubtful stability, (b) the test for its purity is arbitrary, (c) the true molar absorptivity of bilirubin is unknown, (d) due to the various specificities of methods, the calibrant has to be in a protein matrix, (e) the matrix alters the properties of bilirubin and (f) there is no definitive bilirubin assay. The use of a lyophilised human-based bilirubin calibrant should permit accurate standardisation of the method of Jendrassik and Grof and that of Hertz.
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Dissertations / Theses on the topic "Total bilirubin"

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Yaser, Abdallah. "Correlation between transcutaneous bilirubin and total serum bilirubin levels among preterm neonates at Groote Schuur Hospital." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/2791.

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Cadet, Marine. "Vers la conception d’une biopile enzymatique à glucose/oxygène efficace en milieu biologique." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0260/document.

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La première partie du travail présenté ici se concentre sur l’optimisation d’une cathode à oxygène. Tout d’abord, l’utilisation d’une nouvelle enzyme (la BOD de Magnaporthe oryzae) permet de multiplier le courant de réduction de l’oxygène en eau jusqu’à neuf fois. Ensuite la synthèse d’un polymère rédox adapté a permis d’améliorer le coefficient de diffusion des électrons dans l’hydrogel résultant en l’augmentation de la densité de courant générée. Enfin nous sommes passés d’uneélectrode de carbone en 2 dimensions à une fibre d’or poreuse tridimensionnelle. Après modification de cette fibre avec l’hydrogel rédox à base de BOD de M. oryzaenous avons évalué sa biocompatibilité : in vitro les tests ont montré l’absence totale de cytotoxicité et seule une très faible réponse inflammatoire ; in vivo aucune infection ne s’est déclarée pendant les 8 semaines d’implantation dans les souris etla formation d’une capsule fibrotique autour de l’électrode traduit sa bonne intégration dans les tissus de l’animal. La seconde partie concerne la biopile dans son intégralité, construite à partir de la cathode optimisée et d’une anode adaptée à base de GDH. Elle permet de générer jusqu’à 240 μW.cm-2 dans du tampon Pipes/CaCl2 à 5mM de glucose. La biopile a ensuite été testée dans du sang humain total. Un maximum de 129 μW.cm-2 a été obtenu dans un échantillon avec une glycémie de 8,2 mM sous air. De plus nous avons constaté que la densité de puissance délivrée augmente proportionnellement avec la glycémie des différents échantillons de sang testés, faisant de la biopile à la fois une source d’électricité et un biocapteur à glucose ce qui n’avait jamais été démontré auparavant<br>The first part of the work presented here focuses on the optimization of an oxygen cathode. First, the use of a new enzyme (BOD from Magnaporthe oryzae) permit to increase the current of reduction of oxygen into water by a factor nine. Then the synthesis of a suitable redox polymer greatly improved the diffusion coefficient of electrons in the hydrogel, resulting in an increase of the current density. Finally we switched from a two-dimensional carbon electrode to a three-dimensional porous gold fiber. After modification of the fiber with the redox hydrogel based on BOD from M. oryzae, we assessed its biocompatibility: in vitro the tests showed the total absence of cytotoxicity and only a very low inflammatory response; in vivo noinfection appeared during the 8 weeks of implantation in mice and the formation of afibrotic capsule around the device reflects its successful integration into the animal tissues.The second part concerns the full biofuel cell, elaborated from the optimized cathode and an adapted GDH-based anode. It could generate up to 240 μW.cm-2 at 5mMglucose in Pipes/CaCl2 buffer. The biofuel cell was then tested in whole human blood. A maximum of 129 μW.cm-2 was obtained in a sample with 8,2 mM glycaemiaunder air. In addition we observed that the delivered power density increased proportionally with the glycaemia of the different blood samples tested, making the biofuel cell both a power source and a glucose biosensor at the same time which had never been shown before
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Belo, Luís Filipe Barbosa Amado. "Body fat percentage is a major determinant of total bilirubin levels independently of UGT1A1*28 polymorphism in obese children and adolescents." Master's thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/74159.

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Belo, Luís Filipe Barbosa Amado. "Body fat percentage is a major determinant of total bilirubin levels independently of UGT1A1*28 polymorphism in obese children and adolescents." Dissertação, 2014. https://repositorio-aberto.up.pt/handle/10216/74159.

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Book chapters on the topic "Total bilirubin"

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Kumar, Vijay, and Kiran Dip Gill. "To Estimate Total and Direct Bilirubin in Serum." In Basic Concepts in Clinical Biochemistry: A Practical Guide. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8186-6_24.

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Mandal, Šaćira. "Association Between Serum Free Fatty Acids and Total Bilirubin Concentrations in Bosnian Individuals with Diabetes Mellitus Type 2." In IFMBE Proceedings. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-49062-0_44.

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Gupta, Prem, and Neelu Gupta. "Quantitative Estimation of Serum Bilirubin (Direct, Indirect and Total Bilirubin)." In Essentials of Practical Biochemistry. Jaypee Brothers Medical Publishers (P) Ltd., 2017. http://dx.doi.org/10.5005/jp/books/12972_33.

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"Jaundice." In ACoRN: Acute Care of at-Risk Newborns, edited by Jill E. Boulton, Kevin Coughlin, Debra O'Flaherty, and Alfonso Solimano. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197525227.003.0008.

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The jaundice chapter illustrates how to stabilize newborns with hyperbilirubinemia—a common condition—and avoid their developing severe hyperbilirubinemia. Prevention is accomplished by transcutaneous bilirubin testing, total serum bilirubintests, and the use of nomograms to evaluate risk for hyperbilirubinemia and direct appropriate care. Specific risk factors for jaundice and hyperbilirubinemia, treatment thresholds for phototherapy treatment or exchange transfusion, and a bilirubin-induced neurological dysfunction scoring tool for assessing severity in acute bilirubin encephalopathy cases are included. Related procedures, such as the direct antiglobulin test, volume expansion, and intravenous immunoglobulin administration are described. Focal skills, such as plotting and interpreting the nomograms, are applied in the case scenario.
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Ross, Gail S., and Alfred N. Krauss. "Outcome of Neonates with Hyperbilirubinemia." In Cognitive and Behavioral Abnormalities of Pediatric Diseases. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195342680.003.0048.

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Hyperbilirubinemia or jaundice refers to excessive levels of bilirubin in the serum of newborn infants. It is of interest to developmentalists, since serum bilirubin can cross the blood–brain barrier and, in high levels, may cause brain damage, particularly in the globus pallidus, substantia nigra reticulata, subthalamic nucleus, brainstem auditory structures (vestibular and cochlear), oculomotor nuclei, the hippocampus, and the cerebellum. Very high levels of bilirubin can cause the classic acute and chronic bilirubin encephalopathies. Controversy exists as to whether lower levels cause minor neurological, cognitive, or behavioral deficits. Hyperbilirubinemia develops in neonates primarily due to their physiologic immaturity, although other conditions and factors may play a role. Bilirubin is a yellow pigment that results from the breakdown of hemoglobin from red blood cells. In routine clinical practice, bilirubin is measured as total serum bilirubin (TSB). Many healthy full-term infants develop a mild degree of jaundice usually termed “physiologic” jaundice or jaundice not attributable to pathologic factors or disease. The number and rate of breakdown of red cells is higher in the newborn and leads to an increased release of bilirubin to the circulation. The newborn’s liver has reduced capacity to take up bilirubin due to immaturity. Additionally, loss of water in combination with reduced intake of fluid prior to establishment of breast feeding may make the infant jaundiced because of dehydration (Stevenson et al. 2004). Although most neonatal jaundice is physiologic, Table 33.2 lists some of the more common ‘‘pathologic’’ mechanisms causing jaundice in newborns (Stevenson et al. 2004). In actuality, all healthy, full-term infants develop some level of neonatal hyperbilirubinemia as a consequence of physiological immaturity in metabolizing bilirubin, mild dehydration, and/or factors in the breast milk (if they are breast-feeding) (Davidson 1941; Maisels et al. 1986). Clinical jaundice is visible at serum bilirubin levels of approximately 5–7 mg/dL, and approximately 50% (Palmer and Mujsce 2001) of all normal newborns appear jaundiced during the first week of life.
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Bhimte, Bhawna, Ranjit Patil, Rakesh Jagat, Hemant Verma, Daniya Nawaz, and Bubul Kalita. "Biochemical alterations and antioxidant levels in patients living with HIV." In Hypoxia - Recent Advances in the Field of Hypoxic and Ischemic Tissue Damage [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1001893.

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Acquired Immunodeficiency Syndrome (AIDS), is a contagious disease of the immune system caused by Human Immunodeficiency Virus (HIV). Present study aimed to find out biochemical parameters and antioxidant status of people living with HIV with or without co-morbidities. Total 110 patients enrolled in the study, maximum had no co-morbidities 56%, while 30% had tuberculosis. Majority of the patients were unemployed (35.5%) while 21.8% were unskilled workers. Total serum bilirubin (0.95 ± 0.51), total protein (7.22 ± 1.07) and alkaline phosphatase levels (134.52 ± 64.38) were found to be increased while serum albumin level was found to be decreased slightly (4.17 ± 0.79). Total antioxidant level was found to be reduced with or without co-morbidities in HIV patients. The study concluded for regular monitoring of biochemical parameters and antioxidant levels for better management of peoples living with HIV.
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Payne, Nieka. "Prevalence and prognostic value of elevated serum total bilirubin in septic cats and dogs." In BSAVA Congress Proceedings 2020. British Small Animal Veterinary Association, 2020. http://dx.doi.org/10.22233/9781910443774.47.2.

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Torres, Xavier Salord, Kamalan Jeevaratnam, Imogen Schofield, Samantha Taylor, and Pieter Defauw. "REVIEWING THE DIAGNOSTIC THRESHOLDS OF TOTAL SERUM BILIRUBIN TO INDICATE BILIARY OBSTRUCTION IN CATS." In BSAVA Congress Proceedings 2023. British Small Animal Veterinary Association, 2023. http://dx.doi.org/10.22233/9781913859152.40.4.

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Amer, Mashhour Bani. "Assessment of Liver Function Using Hybrid Neuro-Fuzzy Model of Blood Albumin." In Advancing Technologies and Intelligence in Healthcare and Clinical Environments Breakthroughs. IGI Global, 2012. http://dx.doi.org/10.4018/978-1-4666-1755-1.ch011.

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This paper presents an assessment of liver function using novel neuro-fuzzy model of blood albumin level (BA). The developed model that is used to predict the BA consists of four inputs: Asparate Aminotransferace (AST), Alkaline Phosphate (ALP), Total Bilirubin (T. Bil.) and Total Protein (T. Prot.), which are measured in any routine liver function test. The proposed BA model was trained using 211 measured data and a root-mean square error (RMSE) of 0.29 for 100 epochs was achieved. The performance of the developed BA model was validated using 57 testing data sets and RMSE of 0.34 for 100 epochs was achieved. The correlation coefficient (CC) between the predicted and measured values of blood albumin is statistically significant (CC=0.83), which ensures the efficiency and accuracy of developed fuzzy model for predicting BA. The main clinical benefit of this model is that it improves the assessment capabilities of liver diseases and can be used as an integral part of any medical expert system denoted for assessment and diagnosis of liver disorders.
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Liao, Hsien-Hua, Chi-Chang Chang, Yu-Xiang Wang, and Chalong Cheewakriangkrai. "Predicting the Risk Factors of Second Primary Cancer in Patients with Hepatocellular Carcinoma." In Studies in Health Technology and Informatics. IOS Press, 2022. http://dx.doi.org/10.3233/shti210867.

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Screening for cancer and improved treatments have not only improved treatment outcomes and patient survival but have also led to an increase in the number of second primary cancers (SPCs). Hepatocellular carcinoma has been a common occurrence in Taiwan over the past decade. The mortality rate is second only to malignant tumors of lung cancer, and it also represents the fourth highest cancer medical expenditure. This study aimed to use machine learning to identify the risk factors for Hepatocellular carcinoma survivors. Of 378,445 datasets, including 15,251 from patients with SPCs, were collected; 18 predictive variables were considered risk factors for SPCs based on the physician panel discussion. The machine learning techniques employed included support vector machine, C5 decision tree, and random forest. SMOTE (Synthetic Minority Oversampling Technique) sampling method was used to resolve the imbalance problem. The results showed that the top 5 risk factors for SPCs were tumor size, clinical stage, surgery, total bilirubin, and BCLC Stage. The support vector machine method had the highest predicted accuracy (0.7673). The risk factors extracted from the classification models and association rules will be used to provide valuable information for HCC therapy.
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Conference papers on the topic "Total bilirubin"

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Benedetti, Rafael, Frieda Saicla Barros, Diego Rinaldi Pavesi Nicollete, and Marcus Figueredo. "Quantificação de Bilirrubina total por Metodologia de Cromatografia de Fluxo lateral." In X-Meeting / BSB 2023. Even3, 2023. http://dx.doi.org/10.29327/1331270.643318.

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Bilirubin is a pigment metabolite that serves as a liver marker. Could be used to evaluate liver function. This metabolite is coming from Red blood cell degradation, associated with direct liver damag
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Sammir, Md Redwan, Kazi Md Towhidul Alam, Pradipta Saha, Md Mushfiqur Rahaman, and Quazi Delwar Hossain. "Design and Implementation of a Non-invasive Jaundice Detection and Total Serum Bilirubin Measurement System." In 2018 10th International Conference on Electrical and Computer Engineering (ICECE). IEEE, 2018. http://dx.doi.org/10.1109/icece.2018.8636801.

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Chen, Meng, Alain Beuchee, Fabrice Tudoret, and Alfredo Hernandez. "Non-invasive Total Serum Bilirubin Estimation in Preterm Infants with Modified Mixed-Effects Random Forest." In 2024 Computing in Cardiology Conference. Computing in Cardiology, 2024. https://doi.org/10.22489/cinc.2024.120.

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Brit, P. I., M. M. Melamud, D. V. Bobrik, et al. "CHANGES IN LABORATORY BLOOD PARAMETERS OF PATIENTS WITH ALCOHOL WITHDRAWAL SYNDROME IN THE FIRST FIVE DAYS OF HOSPITALIZATION AND THEIR RELATIONSHIP WITH MENTAL SYMPTOMS." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-306.

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The study presents changes in laboratory blood parameters of patients with alcohol withdrawal during the first five days of hospitalisation. It is shown that the level of lymphocytes, platelets, glucose increases in patients. The concentration of total cholesterol, bilirubin, total protein and uric acid decreases. The decrease in AST and ALT correlates with a decrease in alcohol withdrawal syndrome assessment scale scores and insomnia level.
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Slusher, Tina, Isa Abdulkadir, Udochukwu Diala, et al. "Changes in Total and Free Bilirubin Following Treatment for Hyperbilirubinemia: Early Reports From Three Sites in Nigeria." In AAP National Conference & Exhibition Meeting Abstracts. American Academy of Pediatrics, 2021. http://dx.doi.org/10.1542/peds.147.3_meetingabstract.233.

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Ji, Muyao, Tiecheng Li, and Fangsheng Lin. "Research on difference of the total irradiance for bilirubin with the spectral method and the integral method." In Ninth Symposium on Novel Photoelectronic Detection Technology and Applications (NDTA2022), edited by Wenqing Liu, Hongxing Xu, and Junhao Chu. SPIE, 2023. http://dx.doi.org/10.1117/12.2666623.

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Ali Mohammed, Imtithal. "Protective Role of Cranberry Extract Against Zovirax-Induced Spleen Dysfunction in Adult Female Wistar Rats." In XI. International Scientific Congress of Pure, Applied and Technological Sciences (MINAR Congress). Rimar Academy, 2024. https://doi.org/10.47832/minarcongress11-8.

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This research explored a possible protective function of antioxidants, such as cranberries, against zoviraxinduced spleen dysfunction in adult female Wistar rats. A collection of 24(adult female Wistar rats) was haphazardly appointed to four equal sets, each including six animals. They received the following treatment for (0–22–44) days per day. The first group, known as group (C), was obtained in (tap water), and served as a control. The second set (A1) obtained orally 150 mg/kg B.W. of cranberry alone. The third group (A2) received zovirax (450mg/kg B.W.) during the trial to elicit spleen toxicity. In the fourth group (A3), zovirax (450mg/kg B.W.) was administered, plus cranberry (150mg/kg B.W.) was used to alleviate symptoms. Blood samples taken from the orbital sinus were obtained on days (0, 22, and 44) of the experiment, after a fast, to test the serum levels of albumin, total bilirubin (T.B.), globulin, and total serum protein (T.S.P.). After the experiment, splenic slices were taken out for histological analysis. The findings showed that the quantities of total blood protein, albumin, and total bilirubin significantly decreased in rats given zovirax (A2) at a significance level of (P≤ 0.01), accompanying histopathological investigation alterations regarding the histological composition of spleen tissue sections to treat all other sets. However, the protecting function of cranberries was elucidated in the set (A1), encompassing both the histopathological changes and correction of the spleen function mentioned above. Based on these facts, we have determined the results of this study confirmed that cranberries, as an antioxidant, can protect the spleen against zovirax-induced damage in adult females
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Kozinec, A., M. Nadarinskaya, T. Kozinec, O. Golushko, M. Grin', and S. Kovaleva. "HEMATOLOGICAL PROFILE OF LARGE YOUTH CATTLE WHEN FEEDING THE FEED ADDITIVE “MDK”." In SCIENTIFIC SUPPORT FOR LIVESTOCK BREEDING IN SIBERIA. Krasnoyarsk Scientific Research Institute of Agriculture is a separate division of the Federal Research Center KSC SB RAS, 2024. https://doi.org/10.52686/conferencearticle_67597cebeeb813.46602837.

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The blood system is one of the most dynamic systems of the body. The purpose of our research was to study the effect of the feed additive “MDK” on the hematological parameters of the blood of young cattle. The research established the positive effect of the feed additive “MDK” with the yeast Saccharomyces boulardii in the amount of 10 g per head per day on the hematological parameters of the blood of young cattle. The inclusion of the supplement in the diet allowed to increase the number of red blood cells by 3.2%, albumin - by 5.2%, glucose - by 3.1%, total bilirubin - by 9.7%, ALT - by 1.1%, amylase – by 25% and reduce cholesterol levels by 5.6%, triglycerides by 3.6%.
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Shelyakin, I. D., S. N. Semenov, and L. V. Cheskidova. "THE STUDY ON SAFETY (TOLERANCE) OF UNICOCCIDUM ON RABBITS." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. VNIIP – FSC VIEV, 2024. http://dx.doi.org/10.31016/978-5-6050437-8-2.2024.25.457-461.

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Preclinical study of new medicines allows us to determine their specific pharmacological activity, indications for use and contraindications. However, in addition to the efficacy, the choice of a drug depends on its safety profile. The research purpose was to study tolerance (safety) of the anticoccidial drug Unicoccidum on rabbits. The experiment was conducted on rabbits divided into 3 groups. Animals of the first group (n = 6) (control) were prescribed no drugs; rabbits of the second group (n = 8) were administered Unicoccidum once orally, individually, at a therapeutic dose (0.4 mL/kg); and rabbits of the third group (n = 7) were administered the drug at a five-fold therapeutic dose (2.0 mL/kg). Blood for the study was taken from the rabbits’ auricular veins at 7 days after Unicoccidum. The cellular composition of peripheral blood was determined using standard cell counting techniques. Hemoglobin, total protein, urea, calcium, phosphorus, cholesterol, glucose, creatinine, bilirubin, AST, ALT, alkaline phosphatase, and γ-GT were determined with Vital kits (Saint Petersburg) using a Hitachi-902 biochemical analyzer. It was found that Unicoccidum in the studied doses did not significantly affect the clinical status, behavior, or appetite of the rabbits. Morphological and biochemical blood parameters in the experimental animals did not differ from the control and were within the physiological range for this animal species. Thus, Unicoccidum has good tolerance and is safe for animals.
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Roan, Esra, Alex Bada, and Randy Buddington. "Mechanical Characterization of Preterm Neonate Pig Liver as a Function of High-Density Lipoprotein (HDL)." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-39363.

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Elastography, a non-invasive imaging modality, utilizes mechanical properties of tissue as markers for disease diagnosis or staging. In the case of liver, there have been a number of studies focusing on the relationship between elastic mechanical properties and underlying disease, i.e. fibrosis and cirrhosis. In summary, these studies indicate the feasibility of elastographic tools in detecting liver diseases such as fibrosis and steatosis. There have not been any studies looking at the mechanical properties of the preterm neonate liver to date, which is important, because preterm neonates are at a greater risk for developing liver complications due to their aggressive dietary needs that are met with total parenteral nutrition (TPN). They use of elastography may be less from the use of elastographic tools since the concerns over noise levels in measurements resulting from abdominal wall thickness may be less influential. Therefore, it is necessary to establish basic preterm neonate liver mechanical properties. In this study, we measured the nonlinear (hyperelastic) mechanical properties of livers from preterm pigs that were fed common neaonatal diets, i.e. colostrum, total parenteral nutrition (TPN). 16 neonate pigs survived the feeding regime. Mechanical evaluation of 15 of these neonatal pigs was achieved with the use of uniaxial compression experiments at 0.01 s−1 strain rate. The livers averaging a weight of 34.7±7.0 (SD), were stored in phosphate buffered saline solution at 4°C until experimentation, which occurred within 30 minutes of the animal sacrifice. A minimum of three specimens from each liver was required for the computation of averaged mechanical properties. In addition to mechanical testing samples, blood serum was also obtained from these animals and common chemical parameters for liver health were measured (bilirubin, ALT, AST, HDL, LDL, etc.) Exponential form of the hyperelastic strain energy function, W = b1exp[b2(L2 + 2/L-3)], where bi are the material parameters and L is the stretch ratio, was utilized to describe the hyperelastic mechanical behavior of the preterm neonate pig livers. With the use of E = 6b1b2, a small-strain regime estimate of the elastic modulus of the neonate liver tissue was also computed. The mean b1 and b2 parameters are determined to be 97.00±44.15(SD) Pa and 1.90±0.28(SD) (n = 71). The mean elastic modulus exhibited an linear dependence on the HDL values obtained from chemical analysis of the blood serum. Moreover, although relatively weak, the ratio of the HDL over LDL also correlated with the elastic modulus. To our knowledge, this is the only study to date that has focused on the mechanical properties of preterm neonatal pigs and its correlation with liver lipid profile in neonates. Future work will focus on correlating this information with histology and then devising multi-scale material characterization approaches that link underlying neonatal liver structure to its overall mechanical properties.
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Reports on the topic "Total bilirubin"

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Lawanprasert, Somsong, Chaiyo Chaichantipyuth, Supatra Srichairat, Nuansri Niwattisaiwong, and Laddawal Phivthong-ngam. Subchronic exposure of Pueraria mirifica in normal - and high cholesterol diet fed rats : influence on hepatic cytochrome P450, lipid profile and toxicity. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.28.

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Pueraria mirifica airy shaw and suvatabandhu, know locally as Kwao Keur, is a plant in family Leguminosae. In this study, effects of P.mirifica on hepatic cytochrome P450 (CYP), serum lipid profile and subchronic toxicity were investigated in male Wistar rats. Rats were randomly divided into four treatment groups as following: normal diet-fed group; normal diet-fed supplemented with P.mirifica group; high cholesterol diet-fed group; high cholesterol diet-fed supplemented with P.mirifica group. Each group comprised 10 rats. P.mirifica was administered orally at a dosage of 100 mg/kg/day for 90 consecutive days. At the end of the treatment, animals were anesthesized. Blood samples were collected by heart puncture and serum sample were prepared for determination of hematology and clinical blood chemistry, respectively. Microsomes were prepared from livers for enzyme assays. The results showed that body weight of rats given P.mirifica in either normal diet or high cholesterol diet conditions were significantly lower than their corresponding control groups. There was no significant difference of these following hematology and clinical blood chemistry: hemoglobin, hemotocrit, WBC count, %differential WBC, platelet count, RBC morphology, glucose, BUN, SCr, total bilirubin, and direct bilirubin in all experimental groups. P.mirifica did not affect serum level of AST, ALT, and ALP in normal diet-fed condition. High cholesterol diet-fed condition caused a significant increase of AST, ALT, and ALP but P.mirifica attenuated these effects. P.mirifica significantly decreased serum total cholesterol and LDL-C in either normal diet-fed or high cholesterol diet-fed rats. Serum triglyceride was increased in normal diet-fed rats but decreased in high cholesterol diet-fed rats. P.mirifica caused a significant decrease of HDL-C in both normal and high cholesterol diet-fed rats whereas its improvement in the LDL-C/HDL-C ratio was shown only in high cholesterol diet-fed rats. Concerning the effects on CYPs, P.mirifica significantly inhibited CYP2B1&amp;B2 in either normal diet or high cholesterol diet-fed rats. Its inhibitory effect of CYP1A2 and CYP2E1 was found only in normal diet-fed rats. No effect of P.mirifica was found on CYP1A1 and CYP3A. Inhibitory effects of P.mirifica on CYP2B1&amp;2B2 and CYP2E1 were also found in the in vitro study. Although, P.mirifica demonstrated a benefit on lipid profile and did not show any toxic effects on liver, kidney, and blood system in this study, an increment of serum triglyceride in normal rat receiving P.mirifica, howerer, is not favorable. Inhibitory effects of P.mirifica on CYP1A2, CYP2B1&amp;2B2 and CYP2E1 indicated a beneficial potential of this plant regarding the chemical-induced carcinogenesis as well as a possible potential of this plant regarding drug-drug interaction with other medicines that are metabolized by these CYPs. Effects of P.mirifica at various doses, long term used as well as mechanism of effects should be further investigated. Effects of P.mirifica on other isoforms of CYP in human should also be explored.
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