Log in

Relevant bibliographies by topics / TRPV1 / Journal articles

To see the other types of publications on this topic, follow the link: TRPV1.

Journal articles on the topic 'TRPV1'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'TRPV1.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Sharma, Deep, Rekha Rana, and Kiran Thakur. "A REVIEW ON ROLE OF TRPV CATION CHANNELS." Journal of Biomedical and Pharmaceutical Research 10, no. 2 (2021): 32–51. http://dx.doi.org/10.32553/jbpr.v10i2.857.

Full text

Abstract:

The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-sensing (TRPV1, TRPV2, TRPV3, TRPV4) as well as highly Ca2+ selective channels involved in Ca2+ absorption/ reabsorption in mammals (TRPV5, TRPV6). In this review we summarize fundamental physiological p

APA, Harvard, Vancouver, ISO, and other styles

2

Chung, Gehoon, and Seog Bae Oh. "TRP Channels in Dental Pain." Open Pain Journal 6, no. 1 (2013): 31–36. http://dx.doi.org/10.2174/1876386301306010031.

Full text

Abstract:

Despite the high incidence of dental pain, the mechanism underlying its generation is mostly unknown. Functional expression of temperature-sensitive transient receptor potential (thermo-TRP) channels, such as TRPV1, TRPV2, TRPM8, and TRPA1 in dental primary afferent neurons and TRPV1, TRPV2, TRPV3, TRPV4, and TRPM3 in odontoblasts, has been demonstrated and suggested as responsible for dental pain elicited by hot and cold food. However, dental pain induced by light touch or sweet substance cannot be explained by the role of thermo-TRP channels. Most of current therapeutics of dentin hypersensi

APA, Harvard, Vancouver, ISO, and other styles

3

Marshall-Gradisnik, Sonya M., Peter Smith, Ekua W. Brenu, Bernd Nilius, Sandra B. Ramos, and Donald R. Staines. "Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients." Immunology and Immunogenetics Insights 7 (January 2015): III.S25147. http://dx.doi.org/10.4137/iii.s25147.

Full text

Abstract:

Background The transient receptor potential (TRP) superfamily in humans comprises 27 cation channels with permeability to monovalent and divalent cations. These channels are widely expressed within humans on cells and tissues and have significant sensory and regulatory roles on most physiological functions. Chronic fatigue syndrome (CFS) is an unexplained disorder with multiple physiological impairments. OBJECTIVES The purpose of this study was to determine the role of TRPs in CFS. Methods The study comprised 115 CFS patients (age = 48.68 ± 1.06 years) and 90 nonfatigued controls (age = 46.48

APA, Harvard, Vancouver, ISO, and other styles

4

Toledo Mauriño, Joel J., Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, et al. "TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis." Journal of Immunology Research 2020 (May 8, 2020): 1–11. http://dx.doi.org/10.1155/2020/2906845.

Full text

Abstract:

Introduction. TRPVs are a group of receptors with a channel activity predominantly permeable to Ca2+. This subfamily is involved in the development of gastrointestinal diseases such as ulcerative colitis (UC). The aim of the study was to characterize the gene and protein expression of the TRPV subfamily in UC patients and controls. Methods. We determined by quantitative PCR the gene expression of TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6 in 45 UC patients (29 active UC and 16 remission UC) and 26 noninflamed controls. Protein expression was evaluated in 5 μm thick sections of formalin-fixed, paraf

APA, Harvard, Vancouver, ISO, and other styles

5

Kotova, O. O. "Modern concepts of the role of transient receptor potential channel vanilloid subfamily (TRPV) in development osmotic airway hyperresponsiveness in asthma patients (review)." Bulletin Physiology and Pathology of Respiration, no. 81 (September 29, 2021): 115–25. http://dx.doi.org/10.36604/1998-5029-2021-81-115-125.

Full text

Abstract:

Introduction. Airway hyperresponsiveness to osmotic stimuli is often found among patients with asthma. It is assumed that the transient receptor potential channels of vanilloid subfamily (TRPV) may play a key role in the onset of this phenomenon.Aim. Review of modern world literature data on osmotic airway hyperresponsiveness and the role of TRPV channels in its development.Materials and methods. This review summarizes the data from articles published over the past five years found in PubMed and Google Scholar. However, earlier publications were also included if necessary.Results. The influenc

APA, Harvard, Vancouver, ISO, and other styles

6

Yang, Xiao-Ru, Mo-Jun Lin, Lionel S. McIntosh, and James S. K. Sham. "Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle." American Journal of Physiology-Lung Cellular and Molecular Physiology 290, no. 6 (2006): L1267—L1276. http://dx.doi.org/10.1152/ajplung.00515.2005.

Full text

Abstract:

Transient receptor potential melastatin- (TRPM) and vanilloid-related (TRPV) channels are nonselective cation channels pertinent to diverse physiological functions. Multiple TRPM and TRPV channel subtypes have been identified and cloned in different tissues. However, their information in vascular tissue is scant. In this study, we sought to identify TRPM and TRPV channel subtypes expressed in rat deendothelialized intralobar pulmonary arteries (PAs) and aorta. With RT-PCR, mRNA of TRPM2, TRPM3, TRPM4, TRPM7, and TRPM8 of TRPM family and TRPV1, TRPV2, TRPV3, and TRPV4 of TRPV family were detect

APA, Harvard, Vancouver, ISO, and other styles

7

Keller, Melina, Stefan Mergler, Aruna Li, Ingrid Zahn, Friedrich Paulsen, and Fabian Garreis. "Thermosensitive TRP Channels Are Functionally Expressed and Influence the Lipogenesis in Human Meibomian Gland Cells." International Journal of Molecular Sciences 25, no. 7 (2024): 4043. http://dx.doi.org/10.3390/ijms25074043.

Full text

Abstract:

While the involvement of thermosensitive transient receptor potential channels (TRPs) in dry eye disease (DED) has been known for years, their expression in the meibomian gland (MG) has never been investigated. This study aims to show their expression and involvement in the lipogenesis of the MG, providing a possible new drug target in the treatment of DED. Our RT-PCR, Western blot and immunofluorescence analysis showed the expression of TRPV1, TRPV3, TRPV4 and TRPM8 in the MG at the gene and the protein level. RT-PCR also showed gene expression of TRPV2 but not TRPA1. Calcium imaging and plan

APA, Harvard, Vancouver, ISO, and other styles

8

Zhang, Lei, Sarahlouise Jones, Kate Brody, Marcello Costa, and Simon J. H. Brookes. "Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse." American Journal of Physiology-Gastrointestinal and Liver Physiology 286, no. 6 (2004): G983—G991. http://dx.doi.org/10.1152/ajpgi.00441.2003.

Full text

Abstract:

A number of transient receptor potential (TRP) channels has recently been shown to mediate cutaneous thermosensitivity. Sensitivity to warm and cool stimuli has been demonstrated in both human and animal gastrointestinal tract; however, the molecular mechanisms that underlie this have not been determined. Vagal afferent neurons with cell bodies in the nodose ganglion are known to mediate nonnociceptive sensation from the upper gut. In this study, isolated cultured nodose ganglion from the mouse neurons showed changes in cytoplasmic-free Ca2+concentrations over a range of temperatures, as well

APA, Harvard, Vancouver, ISO, and other styles

9

Peng, Gongyong, Wenju Lu, Xiaoyan Li, et al. "Expression of store-operated Ca2+ entry and transient receptor potential canonical and vanilloid-related proteins in rat distal pulmonary venous smooth muscle." American Journal of Physiology-Lung Cellular and Molecular Physiology 299, no. 5 (2010): L621—L630. http://dx.doi.org/10.1152/ajplung.00176.2009.

Full text

Abstract:

Chronic hypoxia causes remodeling and alters contractile responses in both pulmonary arteries and pulmonary veins. Although pulmonary arteries have been studied extensively in these disorders, the mechanisms by which pulmonary veins respond to hypoxia and whether these responses contribute to chronic hypoxic pulmonary hypertension remain poorly understood. In pulmonary arterial smooth muscle, we have previously demonstrated that influx of Ca2+ through store-operated calcium channels (SOCC) thought to be composed of transient receptor potential (TRP) proteins is likely to play an important role

APA, Harvard, Vancouver, ISO, and other styles

10

Kuwashima, Yutaro, Masataka Yanagawa, Mitsuhiro Abe, et al. "Comparative Analysis of Single-Molecule Dynamics of TRPV1 and TRPV4 Channels in Living Cells." International Journal of Molecular Sciences 22, no. 16 (2021): 8473. http://dx.doi.org/10.3390/ijms22168473.

Full text

Abstract:

TRPV1 and TRPV4, members of the transient receptor potential vanilloid family, are multimodal ion channels activated by various stimuli, including temperature and chemicals. It has been demonstrated that TRPV channels function as tetramers; however, the dynamics of the diffusion, oligomerization, and endocytosis of these channels in living cells are unclear. Here we undertook single-molecule time-lapse imaging of TRPV1 and TRPV4 in HEK 293 cells. Differences were observed between TRPV1 and TRPV4 before and after agonist stimulation. In the resting state, TRPV4 was more likely to form higher-or

APA, Harvard, Vancouver, ISO, and other styles

11

Yoo, Hae Young, Su Jung Park, Eun-Young Seo, et al. "Role of thromboxane A2-activated nonselective cation channels in hypoxic pulmonary vasoconstriction of rat." American Journal of Physiology-Cell Physiology 302, no. 1 (2012): C307—C317. http://dx.doi.org/10.1152/ajpcell.00153.2011.

Full text

Abstract:

Hypoxia-induced pulmonary vasoconstriction (HPV) is critical for matching of ventilation/perfusion in lungs. Although hypoxic inhibition of K+ channels has been a leading hypothesis for depolarization of pulmonary arterial smooth muscle cells (PASMCs) under hypoxia, pharmacological inhibition of K+ channels does not induce significant contraction in rat pulmonary arteries. Because a partial contraction by thromboxane A2 (TXA2) is required for induction of HPV, we hypothesize that TXA2 receptor (TP) stimulation might activate depolarizing nonselective cation channels (NSCs). Consistently, we fo

APA, Harvard, Vancouver, ISO, and other styles

12

Blackshaw, L. Ashley, Stuart M. Brierley, Andrea M. Harrington, and Patrick A. Hughes. "TRP Channels in Visceral Pain." Open Pain Journal 6, no. 1 (2013): 23–30. http://dx.doi.org/10.2174/1876386301306010023.

Full text

Abstract:

Visceral pain is both different and similar to somatic pain - different in being poorly localized and usually referred elsewhere to the body wall, but similar in many of the molecular mechanisms it employs (like TRP channels) and the specialization of afferent endings to detect painful stimuli. TRPV1 is sensitive to low pH. pH is lowest in gastric juice, which may cause severe pain when exposed to the oesophageal mucosa, and probably works via TRPV1. TRPV1 is found in afferent fibres throughout the viscera, and the TRPV1 agonist capsaicin can recapitulate symptoms experienced in disease. TRPV1

APA, Harvard, Vancouver, ISO, and other styles

13

Nakazawa, Yosuke, Rosica S. Petrova, Yuki Sugiyama, Noriaki Nagai, Hiroomi Tamura, and Paul J. Donaldson. "Regulation of the Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens." International Journal of Molecular Sciences 22, no. 23 (2021): 12658. http://dx.doi.org/10.3390/ijms222312658.

Full text

Abstract:

Lens water transport generates a hydrostatic pressure gradient that is regulated by a dual-feedback system that utilizes the mechanosensitive transient receptor potential vanilloid (TRPV) channels, TRPV1 and TRPV4, to sense changes in mechanical tension and extracellular osmolarity. Here, we investigate whether the modulation of TRPV1 or TRPV4 activity dynamically affects their membrane trafficking. Mouse lenses were incubated in either pilocarpine or tropicamide to alter zonular tension, exposed to osmotic stress, or the TRPV1 and TRPV4 activators capsaicin andGSK1016790A (GSK101), and the ef

APA, Harvard, Vancouver, ISO, and other styles

14

Gorbunov, Alexandr S., Leonid N. Maslov, Amteshwar S. Jaggi, et al. "Physiological and Pathological Role of TRPV1, TRPV2 and TRPV4 Channels in Heart." Current Cardiology Reviews 15, no. 4 (2019): 244–51. http://dx.doi.org/10.2174/1573403x15666190307112326.

Full text

Abstract:

Transient receptor potential vanilloid channel 2 (TRPV2) is required for normal cardiac contractility. The stimulation of TRPV1 in isolated cardiomyocytes can aggravate the effect of hypoxia/ reoxygenation (H/R) on H9C2 cells. The knockout of the TRPV1 gene promotes increased tolerance of the isolated perfused heart to the impact of ischemia/reperfusion (I/R). However, activation of TRPV1 increases the resistance of the heart to I/R due to calcitonin gene-related peptide (CGRP) release from afferent nerve endings. It has been established that TRPV1 and TRPV2 are involved in the pathogenesis of

APA, Harvard, Vancouver, ISO, and other styles

15

Lötsch, Jörn, Dario Kringel, Gerd Geisslinger, Bruno G. Oertel, Eduard Resch, and Sebastian Malkusch. "Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes." International Journal of Molecular Sciences 21, no. 12 (2020): 4367. http://dx.doi.org/10.3390/ijms21124367.

Full text

Abstract:

Genetic association studies have shown their usefulness in assessing the role of ion channels in human thermal pain perception. We used machine learning to construct a complex phenotype from pain thresholds to thermal stimuli and associate it with the genetic information derived from the next-generation sequencing (NGS) of 15 ion channel genes which are involved in thermal perception, including ASIC1, ASIC2, ASIC3, ASIC4, TRPA1, TRPC1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM8, TRPV1, TRPV2, TRPV3, and TRPV4. Phenotypic information was complete in 82 subjects and NGS genotypes were available in 67 sub

APA, Harvard, Vancouver, ISO, and other styles

16

Cheng, Li, Qing-Qing Luo, and Sheng-Liang Chen. "Expression of TRP Channels in Colonic Mucosa of IBS-D Patients and Its Correlation with the Severity of the Disease." Gastroenterology Research and Practice 2022 (May 29, 2022): 1–7. http://dx.doi.org/10.1155/2022/7294775.

Full text

Abstract:

Aim. Lots of researches have endeavored to elucidate the pathogenetic mechanism of visceral hypersensitivity in order to guide the therapy of diarrhea predominant-irritable bowel syndrome (IBS-D). Transient receptor potential (TRP) channels and their role in visceral nociception have been vastly investigated. We investigated the expression of TRP channels in IBS-D colonic biopsies and its correlation with the severity of the disease. Methods. Sigmoid biopsies were obtained from 34 IBS-D patients and 28 healthy controls (HCs). IBS-D was diagnosed according to Rome IV criteria. Their clinical pa

APA, Harvard, Vancouver, ISO, and other styles

17

Ma, Xinyue, Joshua Shofaro, Xiaoxiao Jia, Zhaohui Ma, and Mizhou Hui. "The Low Molecular Weight Hyaluronan Fragment HA35 Serves as a Dual Antagonist of Pain-Related Calcium Channels TRPV1 and TRPA1." Journal of Pharmaceutical Research International 37, no. 6 (2025): 38–51. https://doi.org/10.9734/jpri/2025/v37i67702.

Full text

Abstract:

Background: Pain, especially chronic pain, remains a major health challenge worldwide. Transient receptor potential (TRP) channels, particularly TRPV1 and TRPA1, play crucial roles in pain perception. Hyaluronic acid (HA), whose bioactivity varies by molecular weight, has shown potential in modulating pain-related TRP channels. However, the effects of low-molecular-weight HA (LMWHA, ＜100 kDa), such as 35 kDa HA (HA35), compared to high-molecular-weight HA (HMWHA, ˃1000kDa), on TRPV1 and TRPA1 are understudied. Methods: This study was performed in vitro using HEK293 cells transiently transfecte

APA, Harvard, Vancouver, ISO, and other styles

18

Kameda, Takuya, Joel Zvick, Miriam Vuk, et al. "Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling." International Journal of Molecular Sciences 20, no. 7 (2019): 1767. http://dx.doi.org/10.3390/ijms20071767.

Full text

Abstract:

Transient receptor potential (TRP) channels have emerged as potential sensors and transducers of inflammatory pain. The aims of this study were to investigate (1) the expression of TRP channels in intervertebral disc (IVD) cells in normal and inflammatory conditions and (2) the function of Transient receptor potential ankyrin 1 (TRPA1) and Transient receptor potential vanilloid 1 (TRPV1) in IVD inflammation and matrix homeostasis. RT-qPCR was used to analyze human fetal, healthy, and degenerated IVD tissues for the gene expression of TRPA1 and TRPV1. The primary IVD cell cultures were stimulat

APA, Harvard, Vancouver, ISO, and other styles

19

Tsagareli, Merab G., Taylor Follansbee, Mirela Iodi Carstens, and Earl Carstens. "Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch." Pharmaceuticals 16, no. 12 (2023): 1707. http://dx.doi.org/10.3390/ph16121707.

Full text

Abstract:

Itch (pruritus) is a sensation in the skin that provokes the desire to scratch. The sensation of itch is mediated through a subclass of primary afferent sensory neurons, termed pruriceptors, which express molecular receptors that are activated by itch-evoking ligands. Also expressed in pruriceptors are several types of Transient Receptor Potential (TRP) channels. TRP channels are a diverse class of cation channels that are responsive to various somatosensory stimuli like touch, pain, itch, and temperature. In pruriceptors, TRP channels can be activated through intracellular signaling cascades

APA, Harvard, Vancouver, ISO, and other styles

20

Huang, Susan M., and Man-Kyo Chung. "Targeting TRPV3 for the Development of Novel Analgesics." Open Pain Journal 6, no. 1 (2013): 119–26. http://dx.doi.org/10.2174/1876386301306010119.

Full text

Abstract:

Decades of characterization of the transient receptor potential vanilloid subtype 1 (TRPV1) have led to the realization of its central role in thermosensation and pain perception. A large number of pharmaceutical companies have had interest in developing TPRV1 antagonists for the treatment of pain. The subsequent discovery of multiple other members of this TRPV family has not gone unnoticed. TRPV3 exhibits approximately 40% homology to TRPV1, and has common as well as distinct features from TRPV1 in channel physiology, expression and function. Here we review the current understanding of TRPV3

APA, Harvard, Vancouver, ISO, and other styles

21

Grigore, Alexandra, Oana Andreia Coman, Horia Păunescu, Mihnea Costescu, and Ion Fulga. "Latest Insights into the In Vivo Studies in Murine Regarding the Role of TRP Channels in Wound Healing—A Review." International Journal of Molecular Sciences 25, no. 12 (2024): 6753. http://dx.doi.org/10.3390/ijms25126753.

Full text

Abstract:

Wound healing involves physical, chemical and immunological processes. Transient receptor potential (TRP) and other ion channels are implicated in epidermal re-epithelization. Ion movement across ion channels can induce transmembrane potential that leads to transepithelial potential (TEP) changes. TEP is present in epidermis surrounding the lesion decreases and induces an endogenous direct current generating an epithelial electric field (EF) that could be implicated in wound re-epithelialization. TRP channels are involved in the activation of immune cells during mainly the inflammatory phase o

APA, Harvard, Vancouver, ISO, and other styles

22

Liedtke, Wolfgang. "Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli." Journal of Endocrinology 191, no. 3 (2006): 515–23. http://dx.doi.org/10.1677/joe.1.07000.

Full text

Abstract:

In signal transduction of metazoan cells, ion channels of the family of transient receptor potential (TRP) have been identified to respond to diverse external and internal stimuli, amongst them osmotic stimuli. This review will highlight findings on the TRPV subfamily, both vertebrate and invertebrate members. Out of the six mammalian TRP vanilloid (TRPV) channels, TRPV1, TRPV2, and TRPV4 were demonstrated to function in transduction of osmotic stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis in vertebrates. Invertebrate TRPV channels, five

APA, Harvard, Vancouver, ISO, and other styles

23

Ghoneum, Mamdooh, James Gimzewski, Aya Ghoneum, Hideki Katano, Clarissa Paw U, and Anshu Agrawal. "Inhibition of TRPV1 Channel Activity in Human CD4+ T Cells by Nanodiamond and Nanoplatinum Liquid, DPV576." Nanomaterials 8, no. 10 (2018): 770. http://dx.doi.org/10.3390/nano8100770.

Full text

Abstract:

Background: Transient receptor potential vanilloid (TRPV) channels act as sensors of pain, temperature, and other external stimuli. We have recently shown that DPV576, an aqueous mixture of nanodiamond (ND) and nanoplatinum (NP), can modulate the activity of TRPV on human primary keratinocytes, suggesting their potential as a possible pain modulator. Here, we sought to examine the effect of DPV576 in modulating the functions of human CD4+ T lymphocytes and whether the modulation is mediated via TRPV channels. Materials and methods: Human primary CD4+ T cells were activated with anti CD3/CD28 w

APA, Harvard, Vancouver, ISO, and other styles

24

Zhang, Hongyu, Peter J. Wickley, Sayantani Sinha, Ian N. Bratz, and Derek S. Damron. "Propofol Restores Transient Receptor Potential Vanilloid Receptor Subtype-1 Sensitivity via Activation of Transient Receptor Potential Ankyrin Receptor Subtype-1 in Sensory Neurons." Anesthesiology 114, no. 5 (2011): 1169–79. http://dx.doi.org/10.1097/aln.0b013e31820dee67.

Full text

Abstract:

Background Cross talk between peripheral nociceptors belonging to the transient receptor potential vanilloid receptor subtype-1 (TRPV1) and ankyrin subtype-1 (TRPA1) family has been demonstrated recently. Moreover, the intravenous anesthetic propofol has directly activates TRPA1 receptors and indirectly restores sensitivity of TRPV1 receptors in dorsal root ganglion (DRG) sensory neurons. Our objective was to determine the extent to which TRPA1 activation is involved in mediating the propofol-induced restoration of TRPV1 sensitivity. Methods Mouse DRG neurons were isolated by enzymatic dissoci

APA, Harvard, Vancouver, ISO, and other styles

25

Naumov, D. E., I. Yu Sugaylo, O. O. Kotova, D. A. Gassan, Ya G. Gorchakova, and T. A. Maltseva. "Comparative characteristics of TRP channels expression levels on the macrophages of patients with chronic obstructive pulmonary disease." Bulletin Physiology and Pathology of Respiration, no. 85 (September 22, 2022): 37–46. http://dx.doi.org/10.36604/1998-5029-2022-85-37-46.

Full text

Abstract:

Introduction. Macrophages are one of the key cells in the pathogenesis of chronic obstructive pulmonary disease (COPD), mediating the primary immune response and coordinating the further reaction of the immune system upon contact with cigarette smoke and air pollutants. It is known that some TRP channels expressed on macrophages are receptors for dust particles and cigarette smoke components.Aim. To study the features of TRPV1, TRPV4, TRPA1 and TRPM8 channels expression on monocyte-derived macrophages and alveolar macrophages of COPD patients and smokers without bronchial obstruction.Materials

APA, Harvard, Vancouver, ISO, and other styles

26

Santoni, Giorgio, Sara Caprodossi, Valerio Farfariello, Sonia Liberati, Angela Gismondi, and Consuelo Amantini. "Antioncogenic Effects of Transient Receptor Potential Vanilloid 1 in the Progression of Transitional Urothelial Cancer of Human Bladder." ISRN Urology 2012 (February 6, 2012): 1–11. http://dx.doi.org/10.5402/2012/458238.

Full text

Abstract:

The progression of normal cells to a tumorigenic and metastatic state involves the accumulation of mutations in multiple key signaling proteins, encoded by oncogenes and tumor suppressor genes. Recently, members of the TRP channel family have been included in the oncogenic and tumor suppressor protein family. TRPM1, TRPM8, and TRPV6 are considered to be tumor suppressors and oncogenes in localized melanoma and prostate cancer, respectively. Herein, we focus our attention on the antioncogenic properties of TRPV1. Changes in TRPV1 expression occur during the development of transitional cell carc

APA, Harvard, Vancouver, ISO, and other styles

27

Everaerts, Wouter, Joris Vriens, Grzegorz Owsianik, et al. "Functional characterization of transient receptor potential channels in mouse urothelial cells." American Journal of Physiology-Renal Physiology 298, no. 3 (2010): F692—F701. http://dx.doi.org/10.1152/ajprenal.00599.2009.

Full text

Abstract:

The bladder urothelium is currently believed to be a sensory structure, contributing to mechano- and chemosensation in the bladder. Transient receptor potential (TRP) cation channels act as polymodal sensors and may underlie some of the receptive properties of urothelial cells. However, the exact TRP channel expression profile of urothelial cells is unclear. In this study, we have performed a systematic analysis of the molecular and functional expression of various TRP channels in mouse urothelium. Urothelial cells from control and trpv4−/− mice were isolated, cultured (12–48 h), and used for

APA, Harvard, Vancouver, ISO, and other styles

28

Ślęczkowska, Milena, Rowida Almomani, Margherita Marchi, et al. "Peripheral Ion Channel Genes Screening in Painful Small Fiber Neuropathy." International Journal of Molecular Sciences 23, no. 22 (2022): 14095. http://dx.doi.org/10.3390/ijms232214095.

Full text

Abstract:

Neuropathic pain is a characteristic feature of small fiber neuropathy (SFN), which in 18% of the cases is caused by genetic variants in voltage-gated sodium ion channels. In this study, we assessed the role of fifteen other ion channels in neuropathic pain. Patients with SFN (n = 414) were analyzed for ANO1, ANO3, HCN1, KCNA2, KCNA4, KCNK18, KCNN1, KCNQ3, KCNQ5, KCNS1, TRPA1, TRPM8, TRPV1, TRPV3 and TRPV4 variants by single-molecule molecular inversion probes–next-generation sequencing. These patients did not have genetic variants in SCN3A, SCN7A-SCN11A and SCN1B-SCN4B. In twenty patients (20

APA, Harvard, Vancouver, ISO, and other styles

29

Zhao, Huan, and Steven M. Simasko. "Role of Transient Receptor Potential Channels in Cholecystokinin-Induced Activation of Cultured Vagal Afferent Neurons." Endocrinology 151, no. 11 (2010): 5237–46. http://dx.doi.org/10.1210/en.2010-0504.

Full text

Abstract:

Cholecystokinin (CCK), an endogenous brain-gut peptide, is released after food intake and promotes the process of satiation via activation of the vagus nerve. In vitro, CCK increases cytosolic calcium concentrations and produces membrane depolarization in a subpopulation of vagal afferent neurons. However, the specific mechanisms and ionic conductances that mediate these effects remain unclear. In this study we used calcium imaging, electrophysiological measurements, and single cell PCR analysis on cultured vagal afferent neurons to address this issue directly. A cocktail of blockers of voltag

APA, Harvard, Vancouver, ISO, and other styles

30

Yu, Weiqun, Warren G. Hill, Gerard Apodaca, and Mark L. Zeidel. "Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium." American Journal of Physiology-Renal Physiology 300, no. 1 (2011): F49—F59. http://dx.doi.org/10.1152/ajprenal.00349.2010.

Full text

Abstract:

The urothelium is proposed to be a sensory tissue that responds to mechanical stress by undergoing dynamic membrane trafficking and neurotransmitter release; however, the molecular basis of this function is poorly understood. Transient receptor potential (TRP) channels are ideal candidates to fulfill such a role as they can sense changes in temperature, osmolarity, and mechanical stimuli, and several are reported to be expressed in the bladder epithelium. However, their complete expression profile is unknown and their cellular localization is largely undefined. We analyzed expression of all 33

APA, Harvard, Vancouver, ISO, and other styles

31

Hudhud, Lina, Katalin Rozmer, Angéla Kecskés, et al. "Transient Receptor Potential Ankyrin 1 Ion Channel Is Expressed in Osteosarcoma and Its Activation Reduces Viability." International Journal of Molecular Sciences 25, no. 7 (2024): 3760. http://dx.doi.org/10.3390/ijms25073760.

Full text

Abstract:

Osteosarcoma is a highly malignant, painful cancer with poor treatment opportunities and a bad prognosis. Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are non-selective cation channels that have been of great interest in cancer, as their expression is increased in some malignancies. In our study we aim to characterize the expression and functionality of the TRPA1 and TRPV1 channels in human and mouse osteosarcoma tissues and in a mouse cell line. TRPA1/Trpa1 and TRPV1/Trpv1 mRNA expressions were demonstrated by PCR gel electrophoresis and RNAscope in situ hy

APA, Harvard, Vancouver, ISO, and other styles

32

Zheng, Jiaojiao, Fangyuan Liu, Sha Du, et al. "Mechanism for Regulation of Melanoma Cell Death via Activation of Thermo-TRPV4 and TRPV2." Journal of Oncology 2019 (February 7, 2019): 1–14. http://dx.doi.org/10.1155/2019/7362875.

Full text

Abstract:

Background. Thermo-TRPs (temperature-sensitive transient receptor potential channels) belong to the TRP (transient receptor potential) channel superfamily. Emerging evidence implied that thermo-TRPs have been involved in regulation of cell fate in certain tumors. However, their distribution profiles and roles in melanoma remain incompletely understood. Methods. Western blot and digital PCR approaches were performed to identify the distribution profiles of six thermo-TRPs. MTT assessment was employed to detect cell viability. Flow cytometry was applied to test cell cycle and apoptosis. Calcium

APA, Harvard, Vancouver, ISO, and other styles

33

Nilius, Bernd, Joris Vriens, Jean Prenen, Guy Droogmans, and Thomas Voets. "TRPV4 calcium entry channel: a paradigm for gating diversity." American Journal of Physiology-Cell Physiology 286, no. 2 (2004): C195—C205. http://dx.doi.org/10.1152/ajpcell.00365.2003.

Full text

Abstract:

The vanilloid receptor-1 (VR1, now TRPV1) was the founding member of a subgroup of cation channels within the TRP family. The TRPV subgroup contains six mammalian members, which all function as Ca2+ entry channels gated by a variety of physical and chemical stimuli. TRPV4, which displays 45% sequence identity with TRPV1, is characterized by a surprising gating promiscuity: it is activated by hypotonic cell swelling, heat, synthetic 4α-phorbols, and several endogenous substances including arachidonic acid (AA), the endocannabinoids anandamide and 2-AG, and cytochrome P-450 metabolites of AA, su

APA, Harvard, Vancouver, ISO, and other styles

34

Balemans, D., J. Aguilera-Lizarraga, M. V. Florens, et al. "Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome." American Journal of Physiology-Gastrointestinal and Liver Physiology 316, no. 3 (2019): G338—G349. http://dx.doi.org/10.1152/ajpgi.00116.2018.

Full text

Abstract:

Previously, we showed histamine-mediated sensitization of transient receptor potential (TRP) vanilloid 1 (TRPV1) in patients with irritable bowel syndrome (IBS). Sensitization of TRP ankyrin 1 (TRPA1) and TRP vanilloid 4 (TRPV4) are also involved in aberrant pain perception in preclinical models of somatic pain. Here, we hypothesize that in parallel with TRPV1, histamine sensitizes TRPA1 and TRPV4, contributing to increased visceral pain in patients with IBS. Rectal biopsies were collected from patients with IBS and healthy subjects (HS) to study neuronal sensitivity to TRPA1 and TRPV4 agonist

APA, Harvard, Vancouver, ISO, and other styles

35

Kiss, Fruzsina, Viktória Kormos, Éva Szőke, et al. "Functional Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Ion Channels Are Overexpressed in Human Oral Squamous Cell Carcinoma." International Journal of Molecular Sciences 23, no. 3 (2022): 1921. http://dx.doi.org/10.3390/ijms23031921.

Full text

Abstract:

Oral squamous cell carcinoma (OSCC) is a common cancer with poor prognosis. Transient Receptor Potential Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) receptors are non-selective cation channels expressed on primary sensory neurons and epithelial and immune cells. TRPV1 mRNA and immunopositivity, as well as TRPA1-like immunoreactivity upregulation, were demonstrated in OSCC, but selectivity problems with the antibodies still raise questions and their functional relevance is unclear. Therefore, here, we investigated TRPA1 and TRPV1 expressions in OSCC and analyzed their functions. TRPA1 and TRPV1 m

APA, Harvard, Vancouver, ISO, and other styles

36

Toth, Balazs I., and Tamas Bíro. "TRP Channels and Pruritus." Open Pain Journal 6, no. 1 (2013): 62–80. http://dx.doi.org/10.2174/1876386301306010062.

Full text

Abstract:

Itch (pruritus) is one of the most often seen sensory phenomena in clinical practice. Recent neurophysiological findings proposed the existence of a novel pruriceptive system which includes a multitude of pruritogenic (itch-inducing) peripheral mediators, itch-selective pruriceptors, sensory afferent networks, spinal cord neurons, and certain central nervous system regions. In this review, we first introduce major features of the pruriceptive system. We then focus on defining the roles of transient receptor potential (TRP) ion channels in skin-coupled itch and provide compelling evidence that

APA, Harvard, Vancouver, ISO, and other styles

37

Shabir, Saqib, William Cross, Lisa A. Kirkwood, et al. "Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium." American Journal of Physiology-Renal Physiology 305, no. 3 (2013): F396—F406. http://dx.doi.org/10.1152/ajprenal.00127.2013.

Full text

Abstract:

In addition to its role as a physical barrier, the urothelium is considered to play an active role in mechanosensation. A key mechanism is the release of transient mediators that activate purinergic P2 receptors and transient receptor potential (TRP) channels to effect changes in intracellular Ca2+. Despite the implied importance of these receptors and channels in urothelial tissue homeostasis and dysfunctional bladder disease, little is known about their functional expression by the human urothelium. To evaluate the expression and function of P2X and P2Y receptors and TRP channels, the human

APA, Harvard, Vancouver, ISO, and other styles

38

Zhang, Guoji, Liqin Wang, Yaxuan Qu, Shilun Mo, Xiaoying Sun, and Kewei Wang. "Inhibition of Cutaneous TRPV3 Channels by Natural Caffeic Acid for the Alleviation of Skin Inflammation." Molecules 29, no. 16 (2024): 3728. http://dx.doi.org/10.3390/molecules29163728.

Full text

Abstract:

Natural caffeic acid (CA) and its analogues have been studied for their potential applications in the treatment of various inflammatory and infectious skin diseases. However, the molecular mechanism underlying the effects of the CA remains largely unknown. Here, we report that CA and its two analogues, caffeic acid phenethyl ester (CAPE) and caffeic acid methyl caffeate (CAMC), inhibit TRPV3 currents in their concentration- and structure-dependent manners with IC50 values ranging from 102 to 410 μM. At the single-channel level, CA reduces the channel open probability and open frequency without

APA, Harvard, Vancouver, ISO, and other styles

39

Bousquet, Jean, Wienczyslawa Czarlewski, Torsten Zuberbier, et al. "Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19." International Archives of Allergy and Immunology 182, no. 4 (2021): 324–38. http://dx.doi.org/10.1159/000514204.

Full text

Abstract:

In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species an

APA, Harvard, Vancouver, ISO, and other styles

40

Payrits, Maja, Ádám Horváth, Tünde Biró-Sütő, et al. "Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification." International Journal of Molecular Sciences 21, no. 14 (2020): 5019. http://dx.doi.org/10.3390/ijms21145019.

Full text

Abstract:

Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons and regulate nociceptor and inflammatory functions. Resolvins are endogenous lipid mediators. Resolvin D1 (RvD1) is described as a selective inhibitor of TRPA1-related postoperative and inflammatory pain in mice acting on the G protein-coupled receptor DRV1/GPR32. Resolvin D2 (RvD2) is a very potent TRPV1 and TRPA1 inhibitor in DRG neurons, and decreases inflammatory pain in mice acting on the GPR18 receptor, via TRPV1/TRPA1-independent mechanisms. We provi

APA, Harvard, Vancouver, ISO, and other styles

41

Wilzopolski, Jenny, Manfred Kietzmann, Santosh K. Mishra, Holger Stark, Wolfgang Bäumer, and Kristine Rossbach. "TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch." Biomolecules 11, no. 8 (2021): 1166. http://dx.doi.org/10.3390/biom11081166.

Full text

Abstract:

Two histamine receptor subtypes (HR), namely H1R and H4R, are involved in the transmission of histamine-induced itch as key components. Although exact downstream signaling mechanisms are still elusive, transient receptor potential (TRP) ion channels play important roles in the sensation of histaminergic and non-histaminergic itch. The aim of this study was to investigate the involvement of TRPV1 and TRPA1 channels in the transmission of histaminergic itch. The potential of TRPV1 and TRPA1 inhibitors to modulate H1R- and H4R-induced signal transmission was tested in a scratching assay in mice i

APA, Harvard, Vancouver, ISO, and other styles

42

Makarieva, Tatyana N., Ekaterina K. Ogurtsova, Yuliya V. Korolkova, et al. "Pulchranins B and C, New Acyclic Guanidine Alkaloids from the Far-Eastern Marine Sponge Monanchora Pulchra." Natural Product Communications 8, no. 9 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800911.

Full text

Abstract:

New marine natural products, pulchranins B and C (2 and 3), were isolated from the marine sponge Monanchora pulchra and their structures were established using NMR and MS analysis. Compounds 2 and 3 were moderately active as inhibitors of TRPV1 (EC50 value of 95 and 183 μM, respectively) and less potent against TRPV3 and TRPA1 receptors.

APA, Harvard, Vancouver, ISO, and other styles

43

Chung, Man-Kyo. "INTRODUCTION - Targeting TRP Channels for Pain Relief: TRPV1 and Beyond." Open Pain Journal 6, no. 1 (2013): 8–9. http://dx.doi.org/10.2174/1876386301306010008.

Full text

Abstract:

Management of chronic and pathological pain without incurring systemic side effects is a major medical challenge.Currently available drugs, such as non-steroidal anti-inflammatory drugs or opioid agonists, are efficacious through peripheral and central mechanisms. However, various complications and development of tolerance are serious problems. Other classes of drugs, such as anti-depressants and anti-convulsants, are often used for multiple pain syndromes. However, the efficacy of these drugs is commonly unsatisfactory, and their mechanism of action is not clear. For establishing novel, selec

APA, Harvard, Vancouver, ISO, and other styles

44

Szallasi, Arpad. "Preface by the Editor." Open Pain Journal 6, no. 1 (2013): 7. http://dx.doi.org/10.2174/1876386301306010007.

Full text

Abstract:

With over 600 reviews, Transient Receptor Potential (TRP) channels arguably represent today’s most extensively reviewed pharmacological targets. The literature on TRP channels is vast and still growing: it has exploded from a mere 21 papers in 1995 to over 2,000 in the past two years. In the past fifteen years, the field had shown spectacular progress. From the cloning of the vanilloid (capsaicin) recep a novel class of analgesic agents.tor TRPV1 in 1997 it has taken only a decade for the first small molecule TRPV1 antagonists to enter clinical trials as So why to add another review collection

APA, Harvard, Vancouver, ISO, and other styles

45

Zhao, Huan, Leslie K. Sprunger, and Steven M. Simasko. "Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in rat." American Journal of Physiology-Gastrointestinal and Liver Physiology 298, no. 2 (2010): G212—G221. http://dx.doi.org/10.1152/ajpgi.00396.2009.

Full text

Abstract:

Vagal afferent neurons relay important information regarding the control of the gastrointestinal system. However, the ionic mechanisms that underlie vagal activation induced by sensory inputs are not completely understood. We postulate that transient receptor potential (TRP) channels and/or two-pore potassium (K2p) channels are targets for activating vagal afferents. In this study we explored the distribution of these channels in vagal afferents by quantitative PCR after a capsaicin treatment to eliminate capsaicin-sensitive neurons, and by single-cell PCR measurements in vagal afferent neuron

APA, Harvard, Vancouver, ISO, and other styles

46

Do, Nayeon, Dongxu Zuo, Miri Kim, et al. "Discovery of Dual TRPA1 and TRPV1 Antagonists as Novel Therapeutic Agents for Pain." Pharmaceuticals 17, no. 9 (2024): 1209. http://dx.doi.org/10.3390/ph17091209.

Full text

Abstract:

Pain management remains a major challenge in medicine, highlighting the need for the development of new therapeutic agents. The transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) are ion channels that play key roles in pain perception. Targeting both TRPA1 and TRPV1 simultaneously with dual antagonists offers a promising approach to pain relief. In this study, we investigated a series of hybrid analogs of TRPA1 and TRPV1 antagonists to discover novel therapeutic agents for pain. Among these compounds synthesized by a condensation reaction forming 1,2,4-oxadiazole between th

APA, Harvard, Vancouver, ISO, and other styles

47

Sakuta, Hiraki, Eri Nishihara, Takeshi Y. Hiyama, Chia-Hao Lin, and Masaharu Noda. "Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 311, no. 2 (2016): R299—R306. http://dx.doi.org/10.1152/ajpregu.00352.2015.

Full text

Abstract:

Water-intake behavior is under the control of brain systems that sense body fluid conditions at sensory circumventricular organs (sCVOs); however, the underlying mechanisms have not yet been elucidated in detail. Nax is a sodium (Na+) level sensor in the brain, and the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 have been proposed to function as osmosensors. We herein investigated voluntary water intake immediately induced after an intracerebroventricular administration of a hypertonic NaCl solution in TRPV1-, TRPV4-, Na x-, and their double-gene knockout (KO) mice.

APA, Harvard, Vancouver, ISO, and other styles

48

Rhyu, Mee-Ra, Yiseul Kim, and Vijay Lyall. "Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1." International Journal of Molecular Sciences 22, no. 7 (2021): 3360. http://dx.doi.org/10.3390/ijms22073360.

Full text

Abstract:

In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation, pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in food consumption. Many plant-derived molecules demonstrate their chemesthetic properties via the opening of transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) channels. TRPA1 and TRPV1 are structurally related thermosensitive cation channels and are often co-expressed in sensory nerve endings. TRPA1 and TRPV1 can also indirectly influence some, but not all, primary

APA, Harvard, Vancouver, ISO, and other styles

49

Gassan, D. A., D. E. Naumov, I. Yu Sugaylo, O. O. Kotova, T. A. Maltseva, and V. P. Kolosov. "Features of TRPV1 and TRPV4 channels expression on subpopulations of peripheral blood monocytes in patients with COPD." Bulletin Physiology and Pathology of Respiration, no. 94 (December 27, 2024): 80–86. https://doi.org/10.36604/1998-5029-2024-94-80-86.

Full text

Abstract:

Introduction. Chronic Obstructive Pulmonary Disease (COPD) is a widespread heterogeneous disease, with smoking and exposure to air pollutants being the main etiological factors. Monocytes and macrophages are among the most important cells involved in the pathogenesis of COPD. It has been established that TRP channels can be activated in response to cigarette smoke in models of respiratory diseases. Previously, we identified the influence of TRP channels on the progression of bronchial obstruction and the peculiarities of their expression on peripheral blood leukocytes in patients with COPD. Ai

APA, Harvard, Vancouver, ISO, and other styles

50

Mori, Noriyuki, Fuminori Kawabata, Shigenobu Matsumura, et al. "Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300, no. 6 (2011): R1494—R1505. http://dx.doi.org/10.1152/ajpregu.00645.2009.

Full text

Abstract:

The transient receptor potential (TRP) channel family is composed of a wide variety of cation-permeable channels activated polymodally by various stimuli and is implicated in a variety of cellular functions. Recent investigations have revealed that activation of TRP channels is involved not only in nociception and thermosensation but also in thermoregulation and energy metabolism. We investigated the effect of intragastric administration of TRP channel agonists on changes in energy substrate utilization of mice. Intragastric administration of allyl isothiocyanate (AITC; a typical TRPA1 agonist

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!