Relevant bibliographies by topics / Undenatured type II collagen (UC-II)

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Undenatured type II collagen (UC-II)'

Author: Grafiati
Published: 5 June 2025
Last updated: 15 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Undenatured type II collagen (UC-II).'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Undenatured type II collagen (UC-II)"

1

Shavlovskaya, O. A., I. A. Bokova, I. D. Romanov, and N. I. Shavlovsky. "Efficacy of undenatured and hydrolyzed type II collagen in the treatment of pain syndrome." Russian Medical Inquiry 6, no. 10 (2022): 571–75. http://dx.doi.org/10.32364/2587-6821-2022-6-10-571-575.

Full text
Abstract:
Collagens play an important structural role and contribute to the mechanical properties, organization and shape of tissues. In musculoskeletal system diseases (MSD), the amount of type II collagen in the cartilage extracellular matrix significantly decreases. Degradation and reduction of type II collagen are associated with osteoarthritis (OA). At present, SYSADOA (Symptomatic Slow Acting Drugs for Osteoarthritis) are widely used in the treatment of OA for oral and parenteral use. Besides, increased attention has been paid to the new treatment methods for OA based on a new promising type II collagen molecule: undenatured (UC-II) and hydrolyzed (HC-II) collagen. UC-II is a native collagen (fibrillar protein with a molecular weight of 300 kDa), whereas HC-II is a polypeptide (molecular weight of 2–9 kDa). The article describes the molecular mechanisms of action of UC-II and HC-II, and identifies the main differences between them. The diverse mechanism of action of the described collagen types determines their clinical use: UC-II is prescribed mainly in MSD, in particular OA, and HC-II is mainly used in cosmetology, as well as in MSD. The article also presents the study results demonstrating the safety and efficacy of drugs and dietary supplements containing UC-II and HC-II in relieving pain syndrome during OA. KEYWORDS: undenatured type II collagen native collagen, hydrolyzed collagen, collagen peptides, SYSADOA, pain syndrome, osteoarthritis. FOR CITATION: Shavlovskaya O.A., Bokova I.A., Romanov I.D., Shavlovsky N.I. Efficacy of undenatured and hydrolyzed type II collagen in the treatment of pain syndrome. Russian Medical Inquiry. 2022;6(10):571–575 (in Russ.). DOI: 10.32364/2587-6821-2022-6-10-571-575.
APA, Harvard, Vancouver, ISO, and other styles
2

Juturu, Vijaya, George Pates, Robert Harris, Shane Durkee, and Zainulabedin Saiyed. "Recovery of Undenatured Collagen Type II from Different Prototypes of Food and Beverages Using Enzyme-Linked Immunosorbent Assay (ELISA)." Current Developments in Nutrition 5, Supplement_2 (2021): 327. http://dx.doi.org/10.1093/cdn/nzab037_037.

Full text
Abstract:
Abstract Objectives According to a new report in 2020, the global functional food market size is projected to reach USD 275.77 billion by 2025 at a CAGR of 7.9%. One of the major growth drivers for this includes increasing demand for nutritional and fortifying food additives. Undenatured type II collagen (UC-II®) is a dietary ingredient derived from chicken sternum and has been shown to improve joint health. The development of undenatured type II collagen in different food and beverage (F&B) products is gaining momentum. The objective of this study was to assess the compatibility and recovery of undenatured type II collagen from different prototypes of F&B. Methods A specific ELISA test that detects the presence of native type II collagen was used to measure undenatured type II collagen content. Results Results showed the recovery of undenatured type II collagen from the F&B matrices varied depending on the pH, pressure, humidity and processing temperature. Highest recovery was seen from F&B prototype of nutritional bars (∼100%), chews (98%), gummies (96%), and dairy beverage (81%). Conclusions In summary, the results from this study shows that UC-II® is able to withstand the processing conditions used for manufacturing F&B products. The applicability of this findings will allow UC-II® to be incorporated into different functional foods thereby helping the consumers to improve their joint mobility, flexibility and comfort. Funding Sources Lonza Consumer Health Ingredients Inc.
APA, Harvard, Vancouver, ISO, and other styles
3

Ekusheva, E. V., E. G. Zotkin, I. S. Dydykina, et al. "Review and resolution of the Council of Experts on the topic «The role of the combination of undenatured type II collagen UC-II, vitamin C, and trace elements in recovering and maintaining the function of the musculoskeletal system, and preservation of health of the joints»." Russian Journal of Preventive Medicine 28, no. 4 (2025): 102. https://doi.org/10.17116/profmed202528041102.

Full text
Abstract:
On October 6, 2024, the Council of Experts held a meeting to discuss «The role of the combination of undenatured type II collagen UC-II, vitamin C, and trace elements in recovering and maintaining the function of the musculoskeletal system and preservation of joint health.» New opportunities in preventing and treating osteoarthritis (OA), including in comorbid patients, are considered. Leading experts in rheumatology, clinical pharmacology, neurology, clinical immunology, orthopedics, traumatology, and sports medicine attended the meeting. The OA phenotypes, the mechanism of action of undenatured type II collagen, the data of clinical studies with undenatured collagen UC II, the integrative, interdisciplinary approach in the prevention and treatment of OA, and the prospects for using the VoltaFlex dietary supplement were analyzed. The resolution of the Council of Experts emphasized the importance of an integrated approach to the treatment of OA, including pharmacological and non-drug methods, and recommended using a combination of undenatured type II UC-II collagen, vitamin C, and trace elements to recover and maintain the musculoskeletal system’s function and preserve joint health.
APA, Harvard, Vancouver, ISO, and other styles
4

Rattanarat, Meechai. "A Literature Review of Undenatured type II collagen (UC-II) in Joint Health and Disease." International Journal of Current Science Research and Review 05, no. 10 (2022): 3818–21. https://doi.org/10.5281/zenodo.7139629.

Full text
Abstract:
<strong>ABSTRACT: </strong>Undenatured type II collagen (UC-II) is supplementary which is from chicken sternum cartilage. (Lugo, J. P., Saiyed,&hellip;,2015) UC-II has undenatured type II collagen componentand. The safety and capability of UC-II in adjusting joint discomfort in Osteoarthritis and Rheumatoid arthritis support by previous preclinical and clinical studies. (Lugo, J. P., Saiyed,&hellip;,2013) Osteoarthritis (OA) is atrophy joint disease affecting the quality of life of the elderly population. A lot of evidence that nutraceuticals from natural herbs may play essential part in inflammation and joint catastrophe in OA. Moreover, various studies these supplements have been found to be proficient in OA. None of these supplements have reported side effects. However, questions connected to their capability and safety for OA prevention and treatment is quality trials are needed to give absolute answers. (Vaishya, R., Agarwal,&hellip;,2018)
APA, Harvard, Vancouver, ISO, and other styles
5

Varney, Jessica L., Jason W. Fowler, and Craig N. Coon. "PSVI-33 Undenatured type II collagen mitigates inflammation and cartilage degeneration in healthy untrained Labrador retrievers after exercise." Journal of Animal Science 98, Supplement_4 (2020): 313–14. http://dx.doi.org/10.1093/jas/skaa278.559.

Full text
Abstract:
Abstract Exercise can cause microtrauma in the tissue and joints of dogs, resulting in a cycle of inflammation and discomfort even in healthy dogs. The aim of this trial was to evaluate the effect of undenatured type II collagen supplemented on inflammation and cartilage degeneration after exercise in untrained, healthy dogs. In this experiment, 40 healthy Labrador retrievers (20m/20f; Range-5-12yrs; Avg-8yrs) were sorted into two groups: undenatured type II collagen group receiving 40mg UC-II® (10mg Collagen Type II/Min. 3% Undenatured Type II Collagen; Lonza Consumer Health, Inc.) and placebo (P) group receiving 40mg maltodextrin daily by capsule. After 2wks supplement loading, all dogs performed a 4.66 ± 0.34km endurance run. Blood was collected at baseline, 1h pre-run, and 24h post-run for hematology/biomarkers including interleukin-6 (IL-6) as an inflammatory marker and cartilage oligomeric matrix protein (COMP) as a cartilage degeneration marker. Undenatured type II collagen supplemented dogs had significantly lower IL-6 vs P at post-run (p&amp;lt; 0.01), as well as significant decreases from pre to post-run (P = 0.03), vs P with no significant change (P = 0.16). COMP was significantly lower in undenatured type II collagen supplemented dogs at 24h post-run compared to pre-run (P = 0.02), with P dogs having no significant differences between timepoints (P = 0.24). At both 1h pre- and 24h post-run undenatured type II collagen supplemented dogs had no significant increases in neutrophil:lymphocyte ratio (NLR; inflammatory marker), but P dogs had significantly higher NLR compared to baseline (P = 0.01). NLR was also significantly lower in undenatured type II collagen supplemented dogs compared to P dogs at pre-run (P &amp;lt; 0.01). Undenatured type II collagen supplemented dogs showed significantly lower white blood cell counts after supplementation compared to P dogs (P &amp;lt; 0.05) (Table 1). In summary, untrained Labrador retrievers supplemented with undenatured type II collagen had decreased inflammation and cartilage degeneration compared to non-supplemented dogs after exercise.
APA, Harvard, Vancouver, ISO, and other styles
6

Gromova, O. A., I. Yu Torshin, A. M. Lila, and O. A. Shavlovskaya. "On the prospects for the use of undenatured type II collagen in the treatment of osteoarthritis and other joint diseases." Modern Rheumatology Journal 16, no. 4 (2022): 111–16. http://dx.doi.org/10.14412/1996-7012-2022-4-111-116.

Full text
Abstract:
Standardized extracts of undenatured type II collagen (UC-II) are used as alternative approaches to the treatment of osteoarthritis (OA). The effect of UC-II extracts is associated with the modulation of the mechanisms of innate and acquired immunity, a decrease in the activity of proinflammatory cytokines and prostaglandins. Epitopes of native collagen in the structure of UC-II contribute to a decrease in the activity of autoimmune reactions that stimulate cartilage degradation. Interacting with discoidin receptors, UC-II accelerates the reconstruction of cartilage connective tissue and inhibits the pro-inflammatory effects of endogenous collagens. Experimental and clinical studies confirm the effectiveness of the use of standardized substances UC-II for acceleration of cartilage regeneration and reduce pain in OA and subclinical joint dysfunction.
APA, Harvard, Vancouver, ISO, and other styles
7

Lau, Francis, Debasis Bagchi, and Siba Raychaudhuri. "Undenatured Type II Collagen (UC-II) in the Treatment of Osteoarthritis." Clinical Immunology 135 (January 2010): S99. http://dx.doi.org/10.1016/j.clim.2010.03.298.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Fernández-Jaén, Tomás F., Carlos González de Vega, Paula Saiz, et al. "Pain reduction and tolerance of type II undenatured collagen in patients with knee osteoarthritis." International Journal of Research in Orthopaedics 9, no. 5 (2023): 900–907. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20232607.

Full text
Abstract:
Background: Osteoarthritis (OA) is the most common cause of pain and disability in adults. Dietary supplements such as undenatured type II collagen (UC-II) have shown to have some benefits in OA treatment. This study aimed to assess changes in pain levels among knee OA patients treated with UC-II for 6 months. Methods: Patients with knee OA of any grade were given a daily 40 mg dose of UC-II (CondroArtil®) as a dietary supplement for 6 months. Pain levels were measured using the visual analog scale (VAS) before starting UC-II 6 months thereafter. A total of 100 patients (62/38: male/female) with a mean age of 46.3±13.8 years participated in the study. Most patients (60%) had mild to moderate OA (grade I or II). Results: The UC-II supplementation was shown to significantly reduce pain levels (p&lt;0.001) with a negative correlation between pain reduction and age (p=0.006) and BMI (p=0.049). The OA severity also affected pain reduction (p=0.011), with grade II OA experiencing higher pain levels. Previous physical therapy and food supplements had a significant impact on pain reduction (p=0.017 and p=0.012, respectively). Conclusions: The study suggests that UC-II is an effective treatment for reducing pain in patients with knee OA.
APA, Harvard, Vancouver, ISO, and other styles
9

Bagchi, Manashi, Andrea Stocker, Ryan Burke, et al. "Efficacy and safety of undenatured type II collagen (UC-II) in arthritic horses." Toxicology Letters 172 (October 2007): S223. http://dx.doi.org/10.1016/j.toxlet.2007.05.563.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Tjandra, Oentarini, Shirly Gunawan, Johan Johan, Fia Fia Lie, Marcella Erwina Rumawas, and Agus Limarta. "Efficacy and Safety of Undenatured Type II Collagen in The Treatment of Osteoarthritis of The Knee: A Randomized, Double-blind, Placebo-controlled Trial." Indonesian Biomedical Journal 15, no. 3 (2023): 277–86. http://dx.doi.org/10.18585/inabj.v15i3.2348.

Full text
Abstract:
BACKGROUND: Available medication for pain and joint stiffness release in osteoarthritis (OA) often gives considerable side effects. Undenatured type II collagen (UC-II) has been considered as a treatment for OA for its ability to prevent the progress of articular cartilage damage. Hence, this study aimed to evaluate the efficacy and safety of UC-II in modulating knee joint function.METHODS: This was a randomized, double-blind, placebo-controlled study involving 102 OA subjects. Subjects were randomized into two groups: receiving an oral daily dose of 40 mg/day UC-II or placebo containing microcrystalline cellulose for 90 days. Efficacy was evaluated by using the Western Ontario McMaster Osteoarthritis Index (WOMAC), Lequesne’s Functional Index (LFI), and Visual Analogue Scale (VAS) score on day-1, -7, -30, -60, and -90. Safety was evaluated by assessing the adverse events (AEs) and abnormal laboratory findings.RESULTS: The WOMAC total score showed a significant difference between the UC-II group vs. the placebo group from day-7 (p&lt;0.05) to day-90 (p&lt;0.01). UC-II was more effective in reducing the WOMAC total scores by 81.6% compared to 19.2% in the placebo group after 90 days. The total LFI and VAS score was significantly reduced in subjects supplemented with UC-II compared to the placebo group (75.8% vs. 7.8%; 67.9% vs. 12.2%, respectively). No significant changes were observed in vital signs and clinical laboratory tests compared to the placebo. The UC-II had a good safety profile with no serious adverse events among participants.CONCLUSION: UC-II significantly improved the knee pain, stiffness, and functional mobility of OA patients and was well-tolerated.KEYWORDS: osteoarthritis, undenatured type II collagen, WOMAC, VAS, LFI
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Undenatured type II collagen (UC-II)"

1

Ramalho, Lília Joana Gonçalves. "Relatório de Estágio e Monografia intitulada "Suplementação de colagénio na osteoartrite: prós e contras"." Master's thesis, 2021. http://hdl.handle.net/10316/98963.

Full text
Abstract:
Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Suplementação de colagénio na osteoartrite: prós e contras RESUMO A osteoartrite é uma doença degenerativa com elevada prevalência, principalmente na população mais idosa, tendo a idade, género e Índice de Massa Corporal como fatores de risco. É causa de diminuição de qualidade de vida e incapacidade por dor e limitação de mobilidade. Por este motivo, é urgente e necessário o desenvolvimento de terapias eficazes.A cartilagem articular é um tecido diferenciado, com função de suporte e de mobilidade, apresentando, por isso, resistência física e mecânica. Na sua constituição e responsáveis por estas características, encontramos os condrócitos e macromoléculas, como o colagénio e os proteoglicanos. O colagénio tem mostrado ação no alívio da sintomatologia articular e tem suscitado interesse para a sua utilização em doentes com osteoartrite, como suplemento alimentar, na forma de colagénio hidrolisado ou colagénio não desnaturado tipo II. Vários estudos pré-clínicos in vitro e in vivo e ensaios clínicos já foram realizados, com o objetivo de avaliar o efeito do colagénio no alívio da sintomatologia e na reparação do dano articular associados à doença osteoartrítica. A presente monografia tem como objetivo abordar criticamente os benefícios e os riscos da suplementação de colagénio na osteoartrite. O relatório de estágio foi realizado durante o meu período de estágio na Farmácia Matias Pereira, onde tive a oportunidade de interferir em todas as etapas do circuito do medicamento. O Farmacêutico Comunitário é o profissional de saúde com mais contacto com os doentes, o que faz dele uma peça fundamental na promoção da saúde e prevenção da doença.<br>ABSTRACT Osteoarthritis is a highly prevalent degenerative disease, especially in the older population, with age, gender and Body Mass Index as risk factors. It causes a decrease in quality of life and disability due to pain and limited mobility. For this reason, the development of effective therapies is urgent and necessary.Articular cartilage is a differentiated tissue, with a support and mobility function, therefore presenting physical and mechanical resistance. In its constitution and responsible for these characteristics, we find chondrocytes and macromolecules, such as collagen and proteoglycans. Collagen has proven effectiveness in the relief of joint symptomatology and has raised interest in its use in patients with osteoarthritis as a food supplement, in the form of hydrolyzed collagen or undenatured type II collagen. Several preclinical in vitro and in vivo studies and clinical trials have been carried out with the aim of evaluating the effect of collagen in relieving symptoms and repairing joint damage associated with osteoarthritis.This monograph aims to critically address the benefits and risks of collagen supplementation in osteoarthritis.The internship report was carried out during my internship period at Matias Pereira Pharmacy, where I had the opportunity to deal with all stages of the medication circuit. The Community Pharmacist is the health professional with the most contact with patients, which makes him an important piece in health promotion and disease prevention.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Undenatured type II collagen (UC-II)"

1

Yoshinari, Orie, Hiroyoshi Moriyama, Manashi Bagchi, and Debasis Bagchi. "Genomics/Proteomics of NEXT-II®, a Novel Water-Soluble, Undenatured Type II Collagen in Joint Health Care." In Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118930458.ch25.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Gupta, Ramesh, Hiroyoshi Moriyama, Manashi Bagchi, Francis Lau, and Debasis Bagchi. "Safety and Efficacy of a Unique Undenatured Type II Collagen in the Treatment of Arthritis." In Arthritis. CRC Press, 2011. http://dx.doi.org/10.1201/b10852-26.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

ROBERTA DAS CHAGAS MENEZES, CLEONE, ANA BEATRIZ RODRIGUES DA SILVA, ANA JÚLIA TORRES SANTOS, et al. "COLÁGENO COMO AGENTE DE MUDANÇA NA OSTEOARTRITE: PERSPECTIVAS DE UMA REVISÃO INTEGRATIVA." In SAÚDE DA MULHER EM FOCO: UM OLHAR MULTIDISCIPLINAR. Editora Academic, 2024. http://dx.doi.org/10.58871/consamu24.c43.

Full text
Abstract:
The present study aims to describe the main methodologies that contribute to the treatment of osteoarthritis through the use of collagen. The present study is a narrative review of the literature, which aims to examine and synthesize the available literature on treatments used in osteoarthritis. Osteoarthritis, in general, has as forms of treatment the use of antiinflammatories, physical measures such as weight loss, muscle strengthening and physiotherapy, as well as infiltrations with corticosteroids. In the most severe cases, the only option was surgical treatment. However, several non-pharmacological therapies can also be used to treat it. Among them, acupuncture, manual therapy, physiotherapy, among others, stand out. However, even if there is a significant relief of symptoms, such means do not guarantee the desired evolution of the disease and may still present some restrictions due to the effects of the disease. Thus, some studies report the efficiency of administering the undenatured form of type II collagen, which can bring better results for chronic inflammation resulting from the disease and enable humoral regulation of immunity through the mechanism of oral tolerance. In conclusion, treatment with the use of this protein plays a fundamental role in the management of the disease, aiming to relieve pain, improve function and quality of life of the patient.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Undenatured type II collagen (UC-II)' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography