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Journal articles on the topic 'UV –Spectrophotometric methods'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Shirkhedkar, Atul A., and Saurabh B. Ganorkar. "NOVEL ZERO ORDER UV-SPECTROPHOTOMETRIC AND FIRST ORDER DERIVATIVE UV-AUC METHODS FOR ESTIMATION OF ETOMIDATE IMPARTING HYDROTROPIC SOLUBLIZATION." INDIAN DRUGS 52, no. 04 (2015): 15–20. http://dx.doi.org/10.53879/id.52.04.10214.

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Simple, novel UV-spectrophotometric methods have been developed and validated for the estimation of etomidate imparting a hydrotropic solublization phenomenon. Etomidate is an imidazole derivative, approved as a short acting intravenous anesthetic having poor water solubility. As the UV-spectrophotometric estimation was not seen in any published literature, we have reported it here; zero order UV-spectrophotometry (Method I) and First Order Derivative UV-spectrophotometry (Method II) with the application of hydrotropy to counteract the poor water solubility of etomidate. The present research e

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Panda, Sagar S., and Ravi Kumar V.V. Bera. "HPTLC AND FIRST DERIVATIVE UV-SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF VILAZODONE IN PHARMACEUTICALS." Indian Drugs 60, no. 01 (2023): 61–66. http://dx.doi.org/10.53879/id.60.01.12718.

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A new HPTLC method and a sensitive UV spectrophotometric method were established for estimating vilazodone hydrochloride in its pharmaceutical formulations. An environment-friendly chromatographic mobile phase consisting of ethyl acetate: toluene: formic acid (5:4:1, V/V/V) along with ultraviolet densitometric detection at 240 nm using pre-coated silica gel plates was used. First derivative UV spectrophotometric determinations were performed using methanol as solvent, and amplitudes were measured for quantification purposes. Validation studies were compliant with ICH guidance. Vilazodone shows

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Wahyuningtyas, Fatma Anggoro, Alda Safitri Maria Ulfa, and Dewi Astri Rahmawati. "Identification of antibiotic by chromatographic and spectrophotometric methods – A Review." Asian Journal of Analytical Chemistry 1, no. 1 (2023): 18–24. http://dx.doi.org/10.53866/ajac.v1i1.270.

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The purpose of this article to review the validation and content of antibiotics using various chromatographic and spectrophotometric methods. This review article used five analytical methods on antibiotics, namely high-performance liquid chromatography (HPLC), Fourier transform infrared (FTIR), gas chromatography (GC), ultraviolet-visible (UV-Vis) spectrophotometer and liquid chromatography/mass spectrophotometer (LC/MS) methods. Antibiotics are the most widely used drugs for infections caused by bacteria. Based on a review of several studies related to antibiotic analysis, the general techniq

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Drozd, J. "Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidum." Acta Facultatis Pharmaceuticae Universitatis Comenianae 59, no. 1 (2012): 22–29. http://dx.doi.org/10.2478/v10219-012-0014-8.

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Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidumA method for the fast determination of dextromethorphani hydrobromidum in pharmaceutical preparations by classic spectrophotometry - zero and first-, second- and third-order derivative spectrophotometry, using "peak - peak" (P - P) and "peak - zero" (P - O) measurements has been performed. The calibration curves are linear within the concentration range of 1.0 - 25.0 μg ml-1 for dextromethorphani hydrobromidum. The procedure is simple, rapid and the results are reliable.

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Omotoso, E. A., and E. B. Unaji. "Comparative evaluation of some moxifloxacin hydrochloride tablet brands marketed in Nigeria using five different validated analytical methods." Nigerian Journal of Pharmaceutical Research 19, no. 1 (2024): 109–19. http://dx.doi.org/10.4314/njpr.v19i1.11s.

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Background: Assay of pharmaceuticals is an important aspect of quality control. It is necessary to compare the bioequivalence of generic brands of the any drug to an innovator/comparator brand as this forms the basis for comparing their therapeutic equivalence.Objective: This study aimed to determine the most accurate method for the assay of moxifloxacin hydrochloride (MOX-HCl) tablet brands in Nigerian markets by using five different validated analytical methods and also verify their interchangeability.Material & Methods: This study involved three brands of MOX-HCl including the comparato

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Bouali, Wiem, Mariem Bouali, Asena Ayse Genc, and Nevin Erk. "DEVELOPMENT AND VALIDATION OF GREEN RP-HPLC AND SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF ALPELISIB IN BULK AND PHARMACEUTICAL DOSAGE FORMS." Ankara Universitesi Eczacilik Fakultesi Dergisi 49, no. 2 (2025): 3. https://doi.org/10.33483/jfpau.1579369.

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Objective: This study aims to develop and validate green analytical methods, specifically UV spectrophotometry, first-order derivative spectrophotometry, and reverse-phase HPLC (RP-HPLC), for determining Alpelisib (ALP) in bulk and pharmaceutical formulations. By comparing the methods using GAPI and AGREE metrics, the study evaluates their environmental friendliness, precision, and applicability. Material and Method: The UV spectrophotometric and RP-HPLC analyses were conducted using Shimadzu UV 1800 and Agilent 1100 HPLC systems, respectively. The mobile phase for HPLC comprised 0.1% trifluor

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Patil, Sushant S., Saurabh B. Ganorkar, and Atul A. Shirkhedkar. "Pharmaceutical Analysis of Eptifibatide via Simple, Rapid, Economical UV-Spectrophotometric Methods." JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT 3, no. 1 (2015): 49–55. http://dx.doi.org/10.15415/jptrm.2015.31004.

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V. U., Barge, Jadhav P. B., Attarde S. R., Kodre K. V., and Patil R. Y. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF MEGLUMINE IN BULK." JOURNAL OF ADVANCES IN CHEMISTRY 10, no. 3 (2014): 2325–28. http://dx.doi.org/10.24297/jac.v10i3.2281.

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UV, first, second and third derivative spectrophotometric methods have been developed for the determination of meglumine. The solutions of standard and sample were prepared in distilled water. For the first method i.e. calibration curve UV spectrophotometric method, the quantitative determination of the drug was carried at 254 nm and the linearity range was found to be 10 – 60 µg/ml. For the first, second, third derivative spectrophotometric methods the drug was determined at 247 nm, 216 nm, 266 nm with the linearity range 10 – 60 µg /ml. The calibration graphs constructed at their wavelength

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S. Panda, Sagar, Ravi Kumar V. V. Bera, and Biswajit Sahu. "APPLICATION OF ICH Q14 CONCEPT FOR CHEMOMETRICS-ASSISTED DEVELOPMENT OF SPECTROPHOTOMETRIC METHODS FOR ESTIMATING PIMAVANSERIN IN TABLETS." Indian Drugs 59, no. 09 (2022): 74–81. http://dx.doi.org/10.53879/id.59.09.12191.

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In the present study, a novel analytical procedure development concept is utilized along with a chemometrics approach. Two sensitive UV spectrophotometric methods were developed for quantifying a new antipsychotic agent, pimavanserin tartarate, in tablets. The scanning speed and sampling interval of the UV spectrophotometric methods were the critical method variables investigated and optimized by a face-centred cubic design during the development phase. A zero-order (222 nm) and a first derivative (maxima: 256 nm and minima: 283 nm) method displayed linear response over 0.5-100 µg mL-1, with i

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Oppe, Tércio Paschke, Júlia Menegola, and Elfrides Eva Scherman Schapoval. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRY AND LIQUID CHROMATOGRAPHY METHODS FOR DETERMINATION OF CEFPIROME IN RAW MATERIAL AND PHARMACEUTICAL DOSAGE." Drug Analytical Research 3, no. 1 (2019): 42–50. http://dx.doi.org/10.22456/2527-2616.93809.

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In the present work, analytical methods, UV Spectrophotometry and Liquid Chromatography (HPLC), were developed and validated for quantification of cefpirome, a broad-spectrum fourth-generation cephalosporin, in raw material and powder for injectable preparation. The UV spectrophotometric method was performed at 271 nm, using 0.1 M hydrochloric acid as solvent. The HPLC was carried out using Techsphere ODS column and mobile phase consisted of methanol-water (30:70, v/v) with flow rate 0.8 mL/min and UV detection at 265 nm. The validation method yielded good results demonstrated statistically th

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Amol, Amrutkar, Aher Smita, and Bachhav Rishikesh. "Development And Validation Of UV-HPLC Method For The Estimation Of Diacerein In Bulk And Tablet Dosage Form." International Journal In Pharmaceutical Sciences 1, no. 1 (2022): 94–103. https://doi.org/10.5281/zenodo.6220056.

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<strong>Objective: </strong>Objective of the present analytical research work was to develop and validate Spectrophotometric method and High Performance Liquid Chromatographic method (HPLC Method) for the Diacerein bulk and tablet dosage form <strong>Methods: </strong>A spectrophotometric method and a HPLC method have been developed and validated for estimation of Diacerein in bulk. <strong>Method A (UV SPECTROMETRY Method): </strong>Methanol was used for the preparation of stock and working standard solutions of the drugs. 400-200nm UV range was used to scanned standard solutions of drugs usi

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Suhartono, Eko, Ari Yunanto, Edi Hartoyo, et al. "UV-Visible Spectrophotometric as a Prospective Tool in Neonatal Sepsis." Indonesian Biomedical Journal 10, no. 1 (2018): 74. http://dx.doi.org/10.18585/inabj.v10i1.360.

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BACKGROUND: This study was aimed to employ the UV-Visible (UV-Vis) spectrophotometry techniques to detect the changes in the blood of neonatal sepsis (NS) subject for a deeper understanding in the pathomechanism of NS.METHODS: The cross-sectional study was conducted from February to May 2017 in the Neonatology Division, Department of Pediatric, Ulin General Hospital/Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia. Blood specimens were taken from newborns, of which 15 each of newborns at risk of sepsis and without risk of sepsis. Data were analyzed by

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Sachin, Bhusari, Karnik Harshavardhan, and Wakte Pravin. "Development and validation of UV-spectrophotometric method for estimation of pterostilbene in Pterocarpus marsupium." World Journal of Advanced Research and Reviews 17, no. 1 (2023): 1123–31. https://doi.org/10.5281/zenodo.8090612.

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<strong>Aim:</strong> To develop and validate a simple, precise and cost effective UV-visible spectrophotometric method for the estimation of pterostilbene in Pterocarpus marsupium extract. All the parameters of the analysis were chosen as per ICH Q2 (R1) guideline. <strong>Methods: </strong>Pterostilbene solution was scanned over UV-visible range for its wavelength of maximum absorbance. Various calibration standards of pterostilbene were prepared. Calibration curve of concentration vs. absorbance was plotted and developed UV – visible spectrophotometry method was used for est

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Samuel, J. Bunu Veronica Aniako Varsharani P. Karade Edebi N. Vaikosen Benjamin U. Ebeshi. "Thin-Layer Chromatographic And UV-Spectrophotometric Analysis Of Frequently Utilized Oral Macrolide Antibiotics." International Journal in Pharmaceutical Sciences 1, no. 9 (2023): 265–74. https://doi.org/10.5281/zenodo.8340601.

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Background: Macrolides are bacteriostatic antibiotics used in the management of mild to chronic soft tissues, and upper and lower respiratory and genitourinary tract infections. Misuse of these agents is common among people with infections, thus leading to the development of bacterial resistance.  Also, due to high demand, there likelihood of fake and substandard products in the markets, hence the need to develop simple, cost-effective, and rapid methods for the analysis and percentage determination of these antibiotics. The study aimed to quantify various samples of macrolide using thin-

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Menegola, Jlia, Martin Steppe, and Elfrides E. S. Schapoval. "Development and Validation of Column High-Performance Liquid Chromatographic and Ultraviolet Spectrophotometric Methods for Citalopram in Tablets." Journal of AOAC INTERNATIONAL 91, no. 1 (2008): 52–58. http://dx.doi.org/10.1093/jaoac/91.1.52.

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Abstract Column high-performance liquid chromatographic (LC) and UV spectrophotometric methods for the quantitative determination of citalopram, a potent and selective serotonin reuptake inhibitor, in tablets were developed. The parameters linearity, precision, accuracy, specificity, robustness, limit of detection, and limit of quantitation were studied according to International Conference on Harmonization guidelines. Chromatography was carried out by the reversed-phase technique on an ACE C18 column with a mobile phase composed of 0.30 triethylamine solutionacetonitrile (55 + 45, v/v) adjust

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Ganorkar, S. B., D. M. Dhumal, and A. A. Shirkhedkar. "APPLICATION OF UV-SPECTROPHOTOMETRY FOR DETERMINATION OF ZILEUTON IN BULK AND IN TABLETS." INDIAN DRUGS 50, no. 06 (2013): 40–44. http://dx.doi.org/10.53879/id.50.06.p0040.

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Zileuton is an orally active inhibitor of 5-lipoxygenase and found to inhibit leukotrienes (LTB4 , LTC4, LTD4 , and LTE4) formation and well-known for the effective treatment of asthma. Rapid, economical and simple ‘Zero order UV-spectrophotometry’ and ‘First order derivative UV-spectrophotometry’ have been developed for estimation zileuton in bulk and in-house tablets. Zileuton showed maximum absorbance at 258.4 nm in 0.01M NaOH. For Zero order UV-spectrophotometric method (Method I), two wavelengths 243.4 nm and 271.0 nm were selected for the determination of area under curve (AUC). In First

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Bhusari, Sachin, Rukayya Shaikh, and Pravin Wakte Pravin Wakte. "Development and Validation of Uv- Spectrophotometric Method for Estimation of Jatamansone in Nardostachys Jatamansi." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 220–28. https://doi.org/10.35629/4494-1002220228.

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Aim: This study aimed to develop and validate a simple, precise, and cost-effective UV- visible spectrophotometric method for the estimation of jatamansone in Nardostachys jatamansi extract. The analysis parameters were selected following the ICH Q2 (R1) guideline. Methods: Jatamansone solution was scanned across the UV-visible range to identify its wavelength of maximum absorbance. Calibration standards of jatamansone were prepared, and a concentration vs. absorbance calibration curve was plotted. The developed UV-visible spectrophotometric method was utilized to estimate jatamansone in stand

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Jain, AK, BK Dubey, D. Basedia, S. Dhakar, M. Ahirwar, and P. Jain. "COMPARISON OF RP-HPLC AND UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF HALOPERIDOL IN PURE AND PHARMACEUTICAL FORMULATION." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 277–82. http://dx.doi.org/10.22270/jddt.v8i5-s.1973.

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An accurate, precise, sensitive and reproducible High-performance liquid chromatographic (HPLC) and UV spectrophotometric methods were developed and validated for the quantitative determination of haloperidol (HPD) in bulk drug and pharmaceutical formulation. Different analytical performance parameters such as linearity, precision, accuracy, specificity, limit of detection (LOD) and limit of quantification (LOQ) were determined according to International Conference on Harmonization ICH Q2B guidelines. The RP-HPLC method was developed by the isocratic technique on a reversed-phase Thermo C18 (2

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Zalat, O. A., Mohamed A. Elsayed, M. S. Fayed, and M. K. Abd El Megid. "Validation of UV Spectrophotometric and HPLC Methods for Quantitative Determination of Chlorpyrifos." International Letters of Chemistry, Physics and Astronomy 21 (November 2013): 58–63. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.21.58.

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A specific and sensitive HPLC and UV spectrophotometric methodwere developed for determination and analysis of chlorpyrifos. Chromatographic separation was achieved on a 150 mm x 10 mm I.D. reversed phase column Zorbax SB C-18. usingdeionizedwater: acetonitrile in the ratio of 10:90 v/v respectively as mobile phase. The effluent was monitored at 290 and 230 nm. Two sharp peaks were obtained for the solvent and chlorpyrifos at 2.7 and 3.45 min respectively. UV spectrophotometric method was performed at 290 nm using Isopropanol as the solvent. Linear range was 0.025-3500 ppm (r2 = 0.9986 ±0.0009

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Zalat, O. A., Mohamed A. Elsayed, M. S. Fayed, and M. K. Abd El Megid. "Validation of UV Spectrophotometric and HPLC Methods for Quantitative Determination of Chlorpyrifos." International Letters of Chemistry, Physics and Astronomy 21 (November 4, 2013): 58–63. http://dx.doi.org/10.56431/p-34082b.

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A specific and sensitive HPLC and UV spectrophotometric methodwere developed for determination and analysis of chlorpyrifos. Chromatographic separation was achieved on a 150 mm x 10 mm I.D. reversed phase column Zorbax SB C-18. usingdeionizedwater: acetonitrile in the ratio of 10:90 v/v respectively as mobile phase. The effluent was monitored at 290 and 230 nm. Two sharp peaks were obtained for the solvent and chlorpyrifos at 2.7 and 3.45 min respectively. UV spectrophotometric method was performed at 290 nm using Isopropanol as the solvent. Linear range was 0.025-3500 ppm (r2 = 0.9986 ±0.0009

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Ankitathaikar*, Rani Madnakari Kiran Patil Priyanka Kankanwadi. "Purification Of 2-Methoxy Naphthalene by UV And IR Spectroscopic Methods." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3182–91. https://doi.org/10.5281/zenodo.15285824.

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The objective of present work is to Purify and characterize by UV and FTIR Spectroscopic method for estimation of 2- methoxy naphthalene in marketed formulation. UV- Spectrophotometric method was developed using Alcohol (99%) as solvent. The developed method was standardized in terms of validation parameters such as simple, sensitive, linear as perICHQ2 (R1).Guidelines for estimation of 2-methoxy naphthalene in marketed Formulation this newly developed method was successfully applied for FTIR Spectrophotometric method was developed using KBr (potassium bromide) process to get insights concerni

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Tsecheev, Arthur T., and Yurii N. Karpenko. "Application of UV spectrophotometry and reversed-phase HPLC to determine the ionization constant of a new biologically active compound." Aspirantskiy Vestnik Povolzhiya 23, no. 2 (2023): 60–65. http://dx.doi.org/10.55531/2072-2354.2023.23.2.60-65.

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Aim to determine the ionization constant (pKa) of the biologically active compound 2-ABPPC by UV spectrophotometry and high performance liquid chromatography (HPLC). Material and methods. The object of the study was the substance 2-ABPPC (2-amino-1-(4-bromophenyl)-5-(3,3-dimethyl-2-oxobutylidene)-4-oxo-4,5-dihydro-1H-pyrrole-3- carboxamide). The methods of UV spectrophotometry and high performance liquid chromatography were used to determine the ionization constant. The spectrophotometric analysis was carried out on a Shimadzu UV-1800 spectrophotometer. The chromatographic determination

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Tejaswini, Kande, Dhekale Pallavi, Khatal Supriya, and Borude Priyanka. "Development and Validation of Analytical Methods for Simultaneous Spectrophotometric Determination of Pioglitazone and Glimepiride by Derivative Method." International Journal of Trend in Scientific Research and Development 4, no. 1 (2019): 822–25. https://doi.org/10.5281/zenodo.3609706.

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A simple, rapid UV Visible spectrophotometric method for the quantification of Pioglitazone hydrochloride and Glimepiride in bulk drug and tablet formulation was developed and validated. UV Visible spectrophotometric methods have been developed for the Derivative Spectrophotometric Method, of Pioglitazone and glimepiride in bulk and pharmaceutical dosage forms. the sampling wavelengths selected are 210 nm and 218 nm over the concentration ranges of 1.5 7.5 Âµg ml and 0.2 1.0 Âµg ml for pioglitazone and glimepiride respectively. Tejaswini Kande | Pallavi Dhekale | Supriy

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Aher, Smita S., Jayshree S. Gawali, and Ravindranath B. Saudagar. "UV-Spectrophotometric Estimation of Olopatadine hydrochloride in Bulk and Pharmaceutical Dosage Form by Zero, First and Second Order Derivative Methods." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 519–24. http://dx.doi.org/10.22270/jddt.v9i4-s.3378.

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Simple and accurate UV spectrophotometric methods by Zero, First and Second order derivative method have been developed and validated for the estimation of Olopatadine hydrochloride in bulk and its pharmaceutical dosage form. The standard and sample solutions of Olopatadine hydrochloride were prepared in methanol and water. Olopatadine hydrochloride was estimated at 299, 289 and 267 nm for the derivative UV-spectrophotometric method. Beer’s law was obeyed in the concentration range of 20 to 120 μg / mL with coefficient of correlation value 0.9996, 0.999 and 0.999 for Zero, First and Second ord

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Atole, Dipali M., and Hrishikesh H. Rajput. "ULTRAVIOLET SPECTROSCOPY AND ITS PHARMACEUTICAL APPLICATIONS- A BRIEF REVIEW." Asian Journal of Pharmaceutical and Clinical Research 11, no. 2 (2018): 59. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.21361.

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Rapid and easy analytical methods are needed due to increasing number of multicomponent formulations, biotherapeutic products and samples of complex matrix in que. Number of Ultraviolet (UV) spectrophotometric methods used for these purpose. Different types of UV spectrometric methods developed on the basis of principle of additivity, absorbance difference, processing absorption spectra. The aim of this review is to present information on simultaneous equation method, difference spectrophotometry, derivative spectrophotometry, absorbance ratio spectra, derivative ratio spectra, successive rati

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Karaşen, N., and S. Altinöz. "Determination of mirtazapine in tablets by UV spectrophotometric and derivative spectrophotometric methods." Journal of Pharmaceutical and Biomedical Analysis 24, no. 1 (2000): 11–17. http://dx.doi.org/10.1016/s0731-7085(00)00394-0.

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Rutvik, Pandya, Kachhiya Heta, N. Desai Mubassira, Patel Dipexa, L. Paradeva Bindiya, and Tandel Jinal. "UV-Spectroscopic Methods Development and Validation for Estimation of Desidustat." Journal of Advances in Pharmaceutical Sciences 2, no. 1 (2024): 42–51. https://doi.org/10.5281/zenodo.10616941.

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<em>Zero order, first order derivative and Difference spectrophotometric methods were developed for routine estimation of Desidustat and validated as per ICH guideline. Linearity obtained for zero order and first order derivative methods from 2-7 </em> <em>g/ml</em><em> with R<sup>2</sup> 0.9965 and 0.9961, respectively and for difference spectrophotometric method 4-12 </em> <em>g/ml</em><em>. with R<sup>2</sup> 0.9978. Standard spiking method for accuracy study was performed and % recovery was found 99.01 to 99.51 % for zero order, 99.49 to 101 % for first order derivative and 99.6 to 10

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Karim, SM Rezaul, Sabiha Ferdowsy Koly, Md Shah Amran, and Shaila Kabir. "In vivo Studies of Protein Binding of Ketorolac in Rat Model by UV-VIS Spectrophotometry and High Performance Liquid Chromatographic Methods." Dhaka University Journal of Pharmaceutical Sciences 15, no. 1 (2016): 63–67. http://dx.doi.org/10.3329/dujps.v15i1.29194.

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In this study, an attempt has been made to determine the protein binding of ketorolac at different time and concentration in rat model. A total of ten rats were used for this study. The rats were subdivided into two groups and 100?g/ml and 200?g/ml of ketorolac were administered through the intra-peritoneal route to rats of group 1 and group 2, respectively. The serum from the rats were collected and analyzed using UV-VIS spectrophotometry and HPLC. In the UV-VIS Spectrophotometric study, the highest percentage of protein binding for ketorolac was found to be 63.067% in group 1 and 74.63% in g

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Khan, Zamir G., Amod S. Patil, and Atul A. Shirkhedkar. "Estimation of Tadalafil Using Derivative Spectrophotometry in Bulk Material and in Pharmaceutical Formulation." International Journal of Spectroscopy 2014 (May 21, 2014): 1–6. http://dx.doi.org/10.1155/2014/392421.

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Four simple, rapid, accurate, precise, reliable, and economical UV-spectrophotometric methods have been proposed for the determination of tadalafil in bulk and in pharmaceutical formulation. “Method A” is first order derivative UV spectrophotometry using amplitude, “method B” is first order derivative UV spectrophotometry using area under curve technique, “method C” is second order derivative UV spectrophotometry using amplitude, and “method D” is second order derivative UV spectrophotometry using area under curve technique. The developed methods have shown best results in terms of linearity,

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M., M. Eswarudu* P. Srinivasa Babu P. Siva Krishna G. Sneha Latha N. Anusha M. S. K. Mounika and N. Punna Reddy. "METHOD DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF DARUNAVIR IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2230–37. https://doi.org/10.5281/zenodo.1215687.

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Two simple, precise and economical UV Spectrophotometric methods have been developed for the estimation of Darunavir ethanolate (DRV) in bulk and its pharmaceutical dosage form. Two methods were developed based on measurement of absorption at maximum wavelengths, for Method Ⅰ 272.1 nm and Method ⅠⅠ 272.4 nm. Linearity for detector response was observed in the concentration range of 2-10 μg/ml for the both methods. The developed methods were validated with respect to linearity, accuracy (recovery), precision and specificity. The accuracy of the methods was assessed by recovery studies and wa

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Ivanovna, Kucherenko Lyudmila, Parniuk Natalia Viktorovna та Khromylova Olga Vladimirovna. "VALIDATION OF THE QUANTITATION METHODS OF 1-(β-PHENYLETHYL)-4-AMINO-1,2,4- TRIAZOLE BROMIDE SUBSTANCE BY SPECTROPHOTOMETRIC METHOD". Asian Journal of Pharmaceutical and Clinical Research 11, № 2 (2018): 231. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.22740.

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Objective: The aim of the work was to determine the validation characteristics for the developed method of quantitation of 1-(β-phenylethyl)-4- amino-1,2,4-triazole bromide substance by absorption spectrophotometry in the ultraviolet region (UV).Methods: For study purposes, the 1-(β-phenylethyl)-4-amino-1,2,4-triazole bromide substance and the standard sample, obtained by the state enterprise “plant of chemical reagents” of scientific and technological complex “institute of single crystals” of the National Academy of Sciences of Ukraine, was used. In the course of our work, we used chemical, p

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Motan, Gabriela, and Aurel Puia. "Studies of different types of aspirin by spectrophotometric methods." Acta Chemica Iasi 22, no. 2 (2014): 155–64. http://dx.doi.org/10.2478/achi-2014-0013.

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Abstract Aspirin (acetylsalicylic acid) is an important anti-inflammatory and analgesic-pyretic drug. FTIR and UV-VIS spectroscopy were used in the present study. Using the FTIR spectroscopy and statistical data analysis the correlation between different types of aspirin was determined. The content of acetylsalicylic acid from the analysed samples was determined by the use of UV-VIS spectroscopy

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Cahyono, Bambang, Christina Setyadewi M., M. Suzery, and Agustina L. N. Aminin. "The Comparison of Spectrophotometric and TLC-Densitometric for DPPH Radical Scavenging Activity Analysis of Three Medicinal Plant Extracts." JKPK (Jurnal Kimia dan Pendidikan Kimia) 5, no. 2 (2020): 110. http://dx.doi.org/10.20961/jkpk.v5i2.40370.

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<p>In this research, Thin Layer Chromatography-Densitometry has proven to be a good method for analyzing 1, 1 diphenyl 2-picrylhydrazyl (DPPH) radical scavenging activity, since this approach displayed the similar trends with UV-Vis spectrophotometric method. Three medicinal plants collected from Semarang used to evaluate both methods. The IC<sub>50</sub> value ranged from 25.26 - 4913.74 ppm shown by UV-Vis spectrophotometric and 24.74 – 4674.61 ppm using TLC-Densitometric. Meniran Dechlorophyllated (<em>Phyllanthus niruri)</em> provides the strongest antioxidant

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Ambadas, R. Rote, and P. Pingle Sunita. "Validated UV-Spectrophotometric Methods for Determination of Gemifloxacin Mesylate in Pharmaceutical Tablet Dosage Forms." E-Journal of Chemistry 7, s1 (2010): S344—S348. http://dx.doi.org/10.1155/2010/346847.

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Two simple, economic and accurate UV spectrophotometric methods have been developed for determination of gemifloxacin mesylate in pharmaceutical tablet formulation. The first UV-spectrophotometric method depends upon the measurement of absorption at the wavelength 263.8 nm. In second area under curve method the wavelength range for detection was selected from 268.5-258.5 nm. Beer’s law was obeyed in the range of 2 to 12 μgmL-1for both the methods. The proposed methods was validated statistically and applied successfully to determination of gemifloxacin mesylate in pharmaceutical formulation.

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Rusu, Aura, Maria-Alexandra Sbanca, Nicoleta Todoran, and Camil-Eugen Vari. "Letrozole Determination by Capillary Zone Electrophoresis and UV Spectrophotometry Methods." Acta Medica Marisiensis 63, no. 2 (2017): 80–86. http://dx.doi.org/10.1515/amma-2017-0022.

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Abstract Objective: Letrozole is a highly potent oral nonsteroidal aromatase inhibitor triazole derivative. The aim of this study was to quantify letrozole from bulk, pharmaceutical formulation, and spiked urine samples by developing a simple, rapid and cost effective capillary electrophoresis method. Methods: A capillary zone electrophoresis method was optimized and validated. Additionally, an UV spectrophotometry method was used for comparing results. Results:The capillary zone electrophoresis method using a 90 mM sodium tetraborate background electrolyte proved to be an efficient method for

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Capitán-Vallvey, Luis Fermin, Ramon Checa-Moreno, and Natalia Navas. "Rapid Ultraviolet Spectrophotometric and Liquid Chromatographic Methods for the Determination of Natamycin in Lactoserum Matrix." Journal of AOAC INTERNATIONAL 83, no. 4 (2000): 802–8. http://dx.doi.org/10.1093/jaoac/83.4.802.

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Abstract Two rapid and simple methods were developed for the determination of natamycin in lactoserum matrix by ultraviolet (UV) spectrophotometry and liquid chromatography (LC) with diode-array detection. The methods involve protein precipitation with methanol, followed by centrifugation. No cleanup is necessary. The applicable concentrations of natamycin in lactoserum range from 2 to 500 mg/L for samples analyzed by both methods. The detection and quantitation limits are 0.07 and 0.23 mg/L, respectively, for the UV spectrophotometric method and 0.1 and 0.32 mg/L, respectively, for the LC met

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Singh, Dharmvir, Neetesh Kumar Jain, Apoorva Tiwari, and Neelam Khan. "Development and Validation of Simultaneous Equation Method for Estimation of Sitagliptin and Saxagliptin in Combined Pharmaceutical Dosage Form by Using UV Spectrophotometric Method." International Journal of Medical Sciences and Pharma Research 8, no. 2 (2022): 83–90. https://doi.org/10.22270/ijmspr.v8i2.43.

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Day by day the number of drug groups also the numbers of drugs within these groups for treatment of diabetes are increasing rapidly. The numbers of newer anti-diabetic formulations either in single or in combined dosage forms are marketed and investigated, sitagliptin with saxagliptin are not official in any pharmacopoeia. the aim of the present work was to develop and validate newer analytical methods like UV spectrophotometric methods, which should be applied for the further analysis of anti-diabetic drugs in bulk drugs and its pharmaceutical formulations. To develop and validate simultaneou

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Sachin Bhusari, Harshavardhan Karnik, and Pravin Wakte. "Development and validation of UV-spectrophotometric method for estimation of pterostilbene in Pterocarpus marsupium." World Journal of Advanced Research and Reviews 17, no. 1 (2023): 1123–31. http://dx.doi.org/10.30574/wjarr.2023.17.1.0116.

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Aim: To develop and validate a simple, precise and cost effective UV-visible spectrophotometric method for the estimation of pterostilbene in Pterocarpus marsupium extract. All the parameters of the analysis were chosen as per ICH Q2 (R1) guideline. Methods: Pterostilbene solution was scanned over UV-visible range for its wavelength of maximum absorbance. Various calibration standards of pterostilbene were prepared. Calibration curve of concentration vs. absorbance was plotted and developed UV – visible spectrophotometry method was used for estimation of pterostilbene in standardized Soxhlet a

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Uncu, Livia, Vladilena Evtodienco, Ecaterina Mazur, Elena Donici, and Vladimir Valica. "Validation of the spectrophotometric method for the dosing of some combined capsule." Moldovan Medical Journal 64, no. 4 (2021): 10–16. http://dx.doi.org/10.52418/moldovan-med-j.64-4.21.02.

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Background: UV-Vis spectrophotometry remains the most accessible spectral method with a high degree of sensitivity and information. The advantage of the method consists in its universality, the ability to combine with other methods, the minimum error, as well as its economic efficiency. The objective of this study was the determination of some validation parameters for the spectrophotometric method of dosing piracetam and nicergoline in combined capsules. Material and methods: Agilent 8453 UV-Vis spectrophotometer, reference standards of piracetam and nicergoline, 0.1 M HCl methanolic solution

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Imre, Silvia, Klára Kacsó, and Daniela-Lucia Muntean. "Simultaneous Determination of Atorvastatin and Amlodipine in Industrial Tablets by Apparent Content Curve and HPLC Methods." Acta Medica Marisiensis 59, no. 1 (2013): 44–48. http://dx.doi.org/10.2478/amma-2013-0010.

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AbstractIntroduction: This study proposes the simultaneous determination of atorvastatin and amlodipine in industrial tablets by a quantitative spectrophotometric method, named the apparent content curve method, test method, and by an HPLC method with UV detection as reference method.Materials and methods: A synthetic mixture and two fixed medicinal combinations containing amlodipine and atorvastatin were investigated by the apparent content curve method, a simple and relatively inexpensive UV-VIS spectrophotometric method based on a mathematical approach derived from the Lambert-Beer law. The

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*Harini, Uppada, Boddapu Divya, and Bonula Harshini. "DEVELOPMENT AND VALIDATION OF A UV SPECTROSCOPIC METHOD FOR DETERMINATION OF SOTAGLIFLOZIN." World Journal of Pharmaceutical Science and Research 4, no. 3 (2025): 114–20. https://doi.org/10.5281/zenodo.15561449.

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<strong>Background and Objective:</strong><strong> </strong>Sotagliflozin is recommended for patients to reduce the risk of heart failure, type 2 diabetes and chronic kidney diseases. Since there were no analytical methods reported for the estimation of Sotagliflozin till date, the present work aims to develop and validate a UV spectrophotometric method for the evaluation of Sotagliflozin in bulk. <strong>Method: </strong>By using Lab India UV spectrophotometer, the standard solution was scanned against blank in the range of 200-400 nm and the λ max was determined using UV Analyst softw

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Gackowski, Marcin, Marcin Koba, Katarzyna Mądra-Gackowska, and Stefan Kruszewski. "Comparison of high-performance thin layer chromatography/UV-densitometry and UV-derivative spectrophotometry for the determination of trimetazidine in pharmaceutical formulations." Acta Pharmaceutica 69, no. 3 (2019): 413–22. http://dx.doi.org/10.2478/acph-2019-0028.

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Abstract New methods for assaying trimetazidine dihydrochloride on the basis of thin layer chromatography and spectrophotometry are proposed and compared in the paper. In HPTLC/UV-densitometry, separation is achieved by using a mobile phase composed of ammonia-methanol (30:70, V/V) on silica gel HPTLC plates F254. Quantification using a non-linear calibration curve is accomplished by densito-metric detection at 230 nm. Derivative spectrophotometric determination of trimetazidine dihydrochloride is carried out from the fourth derivative of the absorbance at 233 nm in peak-zero mode. Statistical

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Mazumder, Md Anisur Rahman, and Parichat Hongsprabhas. "Detection of Genistein in Soy Protein Isolate and Soymilk Powder by Spectrophotometric and Chromatographic Method." Journal of Food Science and Technology Nepal 11 (December 31, 2019): 69–73. http://dx.doi.org/10.3126/jfstn.v11i0.16920.

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Genistein proposed as a treatment for osteoporosis for postmenopausal women, elderly men, lowering cardiovascular disease and reduces hormone dependent cancers. Genistein also exerted inhibitory effect on lipid peroxidation induced in vitro by pro-oxidant agents on model and natural membranes on cultured cells and on low density lipoprotein. Genistein detection in soy products is very much important for Food Scientist. Gensitein can be detected by UV-Visible spectrophotometric and HPLC method. This study focused on the detection of genistein by HPLC and spectrophotometric methods. Genistein co

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Lestari, Ida, Peni Pujiastuti, and Yari Mukti Wibowo. "Komparasi Metode Titrimetri Dengan Spektrofotometri UV-Vis pada Analisis Chemical Oxygen Demand (COD) Output IPAL Domestik Berdasarkan Linieritas, Akurasi dan Presisi." JURNAL SAINS TEKNOLOGI & LINGKUNGAN 9, no. 4 (2023): 592–602. http://dx.doi.org/10.29303/jstl.v9i4.416.

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The method of a test must be evaluated and tested to ensure that the method is capable of producing valid data. So that validation needs to be done as a quality control that provides assurance that the measurements and results obtained are reliable. This study aims to determine the value and comparison of the values of linearity, accuracy, and precision of the titrimetric and spectrophotometric methods in COD analysis. Determination of the COD value for the titrimetric method was carried out by redox titration using a solution of Ferro Ammonium Sulphate (FAS). While the spectrophotometric meth

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Yasir, Mehmood, Khalid Mahmood Rana, and Akram Waqas. "Development and validation of UV-spectrophotometric methods for quantitative estimation of Drotaverine HCl injection." Pharmaceutical Methods 8, no. 1 (2017): 01–05. https://doi.org/10.5281/zenodo.14854594.

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Introduction: The objective of this study is to develop and validate spectrophotometric method for Drotaverine HCl injection analysis. A very simple, unique, novel, protective, secured, reliable and quick method of spectrophotometric estimation in UV-region has been developed for the assay of Drotaverine HCl injection formulation. Method: Methanol and water were used as diluents for the assay of Drotaverine HCl. Results: However no interference was observed in spectrophotometric determinations. ICH guidelines were followed during selection of parameters and these were then validated statistica

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Syed Ansar Ahmed and Sushil Jaysing Jadhav. "Development and Validation of Stability-Indicating RP-HPLC and UV Spectrophotometric Methods for Quantitative Determination of Hydroquinone in Pharmaceutical Formulations." Journal of Pharma Insights and Research 3, no. 3 (2025): 269–76. https://doi.org/10.69613/0dkcxn76.

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This research work focusses on two validated analytical methods for the quantification of hydroquinone in pharmaceutical formulations using reverse-phase high-performance liquid chromatography (RP-HPLC) and UV spectrophotometry. The RP-HPLC method utilized an Agilent C18 column (250 mm × 4.6 mm, 5 μm) with a mobile phase consisting of methanol and 0.05% orthophosphoric acid (50:50 v/v, pH 3.7) at a flow rate of 0.7 mL/min. Detection was performed at 290 nm with a retention time of 3.859 minutes. The UV spectrophotometric method was developed using methanol as the solvent, with measurements tak

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CH., V. S. Gautam* N. Harika V. Balaji V. Srinivas Prasad. "METHOD DEVELOPMENT AND VALIDATION OF DACLATASVIR IN BULK & PHARMACEUTICAL DOSAGE FORM BY UV-VISIBLE SPECTROPHOTOMETRY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1980–85. https://doi.org/10.5281/zenodo.1213232.

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Objective: The objective of the present work is to develop a simple, efficient, and reproducible spectrophotometric method for the quantitative estimation of hepatitis-C drug - Daclatasvir in active pharmaceutical ingredient(API) form and in pharmaceutical dosage form Methods: The developed ultraviolet spectrophotometric method for the quantitative estimation of hepatitis-C drugs - Daclatasvir based on measurement of absorption at a wavelength maximum (λmax) of 317 nm using methanol as solvent. Results: The method was validated in terms of, precision, linearity, accuracy, and robustness

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Harsha K M, Suresha D N, and Naveen Kumar G S. "Current Advances in Analytical Methods for Quantification of Bilastine." Journal of Pharma Insights and Research 3, no. 1 (2025): 228–35. https://doi.org/10.69613/tgjzdv19.

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Bilastine, a second-generation H1-antihistamine, has gained significant importance in treating allergic rhinoconjunctivitis and urticaria. The development of precise, accurate, and robust analytical methods for bilastine quantification is crucial for pharmaceutical quality control and research applications. Recent analytical approaches encompass UV spectrophotometry, reverse-phase high-performance liquid chromatography (RP-HPLC), and high-performance thin-layer chromatography (HPTLC). UV spectrophotometric methods have demonstrated linearity in ranges of 5-25 μg/mL with detection limits as low

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B., H. M. Mruthyunjayaswamy, M. Mali Patil S., and Appala Raju S. "Spectrophotometric determination of ornidazole." Journal of Indian Chemical Society Vol. 81, Apr 2004 (2004): 346–48. https://doi.org/10.5281/zenodo.5832501.

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Department of Chemistry, Gulbarga University, Gulbarga-585 106, India <em>E-mail</em> : bhmmswamy@rediffmail.com H. K. E. S.'s College of Pharmacy, Gulbarga-585 105, India <em>Manuscript received 14 January 2003, revised 4 August 2003, accepted 29 September 2003</em> Three simple, sensitive, selective and economical methods (method A, B and C) for the determination of ornidazole have been described. Method A, B and C are based on the formation of yellow, blood red and blue coloured chromogens when reduced ornidazole <em>in situ</em> reacted with vanillin, 1,10-phenanthroline in presen

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Dagdu, Kedar Vikas, Manoj Gadhave, Shubham Bhujbal, and Bhushan Shrinath. "Area Under Curve by UV Spectrophotometric Method for Determination Albendazole in Bulk." Journal of Drug Delivery and Therapeutics 9, no. 6 (2019): 47–50. http://dx.doi.org/10.22270/jddt.v9i6.3667.

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The aim of present investigation is to establish simple, precise, and rapid Spectrophotometric method for the quantification of Albendazole in Active Pharmaceutical Ingredient. In this, work is carried out to for estimation of Albendazole bulk by utilizing an Area under Curve (AUC) method using UV – Visible Spectrophotometry. The study is designed to validate the developed methods as per ICH guidelines. For this purpose the wavelength range between 200-400 nm was selected. Methanolic distilled water (50 ml methanol used for stock solution and serial dilution in 25 ml distilled water) was used

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