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Koeshe, Valentia Puleng. "The effect of an adapted personal growth training programme on female victims of domestic violence in Potchefstroom / Koeshe V.P." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7353.
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Violence against women in cohabiting and marital relationships is, at present, a prominent
phenomenon in South Africa. Domestic violence against women and children in South Africa
is widespread and on the increase, also in Potchefstroom. Yet limited interventions are
available. The interventions that are available include the SAPS, the court for the protection
order, NGO’s and social workers. Female victims need measures that focus on building and
empowering them with skills. Therefore the researcher adapted the Personal Growth
Programme of FAMSA in Welkom to cater for the needs of female victims of domestic
violence who are currently or were previously in an abusive relationship. The newly
formulated Personal Empowerment Training Programme (PETP) is a tool that provides the
female victims with the opportunity to deal with poor self–image, emotional demoralisation,
loss of selfhood, self–blame and shame.
Aim
The aim of the research was to determine the effect of the PETP on the knowledge, attitude
and behaviour of female victims of domestic violence in Potchefstroom.
Method
The main core of the research can be depicted as programme evaluation in which an
evaluative research design was used. In the main study an experimental group was subjected
to the PETP, while the control group was not. However, both experiential group and control
group had to complete the pre–post questionnaire.
Results
The results proved that the PETP had a positive impact on the knowledge, attitude and
behaviour of female victims affected by domestic violence.Thesis (M.A. (MW))--North-West University, Potchefstroom Campus, 2012.
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Delgado, Camila Nardy. "Biologia reprodutiva, distribuição espacial e conservação de Hadrolaelia coccinea (Lindl.) Chiron & V.P. Castro (Orchidaceae, Laeliinae) no Parque Estadual do Ibitipoca, Minas Gerais, Brasil." Universidade Federal de Juiz de Fora (UFJF), 2018. https://repositorio.ufjf.br/jspui/handle/ufjf/6902.
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As interações ecológicas são de extrema importância para todo ecossistema, as relações entre plantas e polinizadores possuem um papel estruturador para os sistemas naturais e agrícolas. A fase reprodutiva é um momento marcante na vida de qualquer organismo, influenciado pelas condições bióticas e abióticas, que desenha as características reprodutivas. Desta forma, a distribuição das espécies está altamente relacionada com os mecanismos de dispersão e condições do local para determinar a densidade e a alta diversidade de espécies, que encontramos no planeta. Além disso, muitas vezes o impacto antrópico é um fator marcante em toda essa relação. Orchidaceae é uma família cosmopolita encontrada em quase todos os continentes da Terra, exceto na Antártida, com cerca de 24500 espécies. No Brasil o domínio da Floresta Atlântica se destaca em número de espécies, chegando a 50% de todas as espécies encontradas no país. Laeliinae é a terceira maior subtribo de Orchidaceae, com cerca de 2080 espécies exclusivamente distribuídas na Região Neotropical, sendo muitas vezes desejadas por colecionadores devido à imensa diversidade morfológica e cromática de suas flores. Hadrolaelia coccinea (Lindl.) Chiron & V.P.Castro ocorre nas regiões Sul e Sudeste do Brasil, sendo endêmica do domínio Atlântico. As flores têm como característica principal sua coloração vermelho intenso, tendo grande apelo ornamental. No Parque Estadual do Ibitipoca esta espécie possui um histórico de coleta predatória, onde uma subpopulação está extinta no local. Deste modo, foi realizado um estudo avaliando aspectos da biologia reprodutiva, distribuição espacial e impacto antrópico no intuito de avaliar a situação da espécie no referido parque. No primeiro capítulo foi realizado um estudo de biologia reprodutiva avaliando fenologia, ocorrência de possíveis polinizadores, aspectos da biologia floral, sistema de cruzamentos, e sementes viáveis de frutos provenientes da polinização natural, através do teste do tetrazólio. O sistema de floração encontrado é anual com duração intermediária, como principal estratégia GFD – Generalized Food Deception, por não oferecer recompensa floral para seu polinizador, enganando-o pela semelhança cromática com outra espécie, a qual compartilha características morfológicas e que oferta néctar. Pelas características florais, o mecanismo de polinização é “Key-hole flower” tendo o beija-flor como potencial polinizador. Apresenta um sistema autocompatível e alogâmico, com a polinização cruzada como via de regra, visto que existe a presença de uma barreira física que evita a autopolinização. Por conseqüência, apresenta baixa taxa de frutificação, mas com elevado número de sementes. No segundo capítulo foi avaliada a distribuição espacial de H. coccinea através de transectos de 200 x 8 m distribuídos no interior e borda da nanofloresta nebular, na transição com o arbustal nebular. Sua distribuição espacial foi avaliada através do Índice Morisita (IM) e da Razão da Variância/Média (R). Os indivíduos nos dois ambientes foram contabilizados em grupos de jovens e adultos, registrando-se os forófitos. A significância estatística dos testes foi comparada pelo teste t. A correlação da circunferência do tronco com a abundância de indivíduos de H. coccinea foi feita através de uma regressão linear. Os resultados mostraram um padrão de distribuição agregada, com diferença de abundância entre os ambientes de interior e borda da nanofloresta nebular, mas a densidade de indivíduos jovens e adultos não teve diferença significativa. Há preferência por uma espécie de forófito, Eremanthus erythropappus (DC.) MacLeish (Asteraceae), popularmente chamada de candeia, com o CAP apresentando uma pequena influência na densidade de indivíduos nos forófitos. No terceiro capítulo foi avaliado o impacto antrópico sobre H. coccinea pela atividade de turistas, através do estabelecimento de quatro transectos de 200 x 8 m em dois ambientes, onde a passagem dos turistas não é permitia (ST) e em que a passagem é permitida (T), e registrada a abundância de indivíduos nos forófitos. A significância estatística foi realizada pelo teste Mann-Whitney. A subpopulação onde a passagem dos turistas é permitida está com uma baixa taxa de indivíduos, contrapondo o que ocorre no ambiente em que a passagem de turistas não é permitida (ST), apresentando uma subpopulação com elevado número de indivíduos.
Ecological interactions are of extreme importance to every ecosystem, once the relationships between plants and pollinators have a structuring role for natural and agricultural systems. The reproductive phase is a defining moment in the lifecycle of any organism, influenced by the biotic and abiotic conditions, that draws the reproductive characteristics. In this way the distribution of the species is highly related to the mechanisms of dispersion and conditions of the place to determine the density and the high diversity of species that we find in the planet. Furthermore, often the anthropogenic impact is a striking factor in this whole relationship. Orchidaceae is a cosmopolitan family found in almost all continents of the Earth, except in Antarctica, with about 24500 species. In Brazil the domain of the Atlantic Forest stands out in number of species, reaching 50% of all species found in the country. Laeliinae is the third largest subtribe of Orchidaceae, with about 2080 species exclusively distributed in the Neotropical Region, being often desired by collectors due to the morphological and chromatic diversity of their flowers. Hadrolaelia coccinea (Lindl.) Chiron & V.P.Castro occurs in the South and Southeast regions of Brazil, being endemic to the Atlantic Domain. The flowers are main characteristic is its intense red color, with great ornamental appeal. In the Parque Estadual do Ibitipoca this species has a predatory collection history, where a subpopulation is extinct in the place. In this way, a study was carried out evaluating aspects of the reproductive biology, spatial distribution and anthropogenic impact in order to evaluate the situation of the species in said park. In the first chapter the study of biology reproductive was fullfiled assessing phenology, possible pollinators, aspects of floral biology, crossing systems and viable sees of natural pollinations, through the tretazolium test. The system is described annual - flowering patterns, with main strategy - GFD – Generalized Food Deception, for not offering floral reward for its pollinator, deceiving him through the another species with which she shares morphological characteristics and which offer nectar. By the floral characteristics the mechanism of pollination is "Key- hole flower" having the hummingbird as a potential pollinator. It presents a self- compatible and allogamic system, with cross-pollination as a rule, since there is the presence of a physical barrier that avoids self-pollination. Consequently, it presents a low fruiting rate, but with a high number of seeds. In the second chapter was evaluated the spatial distribution through of four transects of 200 x 8 m distributed inside and border of dwarf cloud forest, in transition cloud shrub. Your spatial distribution was evaluates through os Índice Morisita (IM) Variance/Avarage rate (R). The individuals in the both environment were accounted in groups of youth and adults, registering the forophytes. The statistical significance of test was compared by test t. The correlation of circumference of the trunks with the abundance of individuals of H. coccinea was done through of a linear regression. The results showed an aggregate distribution pattern, with differences of abundance between the interior and border environments of the dwarf cloud forest, but the density of young and mature individuals did not have significant difference. There is a preference for a species of phorophyte, Eremanthus erythropappus (DC.) MacLeish (Asteraceae), popularly called candeia, with CAP having a small influence on the density of individuals on the phorophytes. In the third chapter we evaluated the anthropogenic impact on H. coccinea in areas where the circulation of tourists, through the establishment of four transects of 200 x 8 m in two environment, at where tourists pass are allowed (T) and circulation is not allowed (ST), and registrer the abundance of individuals in the forophytes. The statistical significance was fulfill of Mann-Whitney. The subpopulation of T presents a low rate of individuals, opposing what occurs in the environment ST, which presents a subpopulation with high number of individuals.
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Panesar, K., and Kulvinder Panesar. "New extended Computer Science curriculum model: USE-VQP-VCP (University, Students and Employers – Vendor Qualification Providers – Value Chain Partnership)." AdvanceHE, 2019. http://hdl.handle.net/10454/18137.
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YesEmpirically Computer Science (CS) and IT-related graduates are failing to secure specialist posts in the first three years after graduation due to limited skills and specialist experience. This issue contributes to the future skills gap of professionals for our technology-driven world. Consequently there is a growing vendor qualifications market; creditability of digital wallets and their global acceptance. We propose a new CS curriculum business value model comprising academia; embedded yearly industry qualifications; annual short placements (increased employer engagement); industrial placement; an extended academic year; fees (marginal increase). Benefits include: expediting graduates to achieve their long-term goals; skills gap minimised; and employers recruiting ready professionals.
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Lee, Philip. "'V.T.'." Thesis, Lancaster University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403894.
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This essay is in three parts. Each part, or short essay, deals with a novel that has a collection of poetry appended to it. The novels are 'Big Sur' by Jack Kerouac, 'How to Save Your Own Life' by Erica Jong, and 'V.T.' by Philip Lee. In the short essays I explore some of the relationships between the poetry and prose in the novels, and touch on how the authors present themselves by the inclusion of poetry, ostensibly written by them. Note on why I've chosen to include essays on 'Big Sur' and 'How to Save Your Own Life': I've been a fan of Kerouac since my late teens, and Jong since my early twenties (I was born in 1956). Specifically, I've admired Kerouac for his depiction of men in search of a purpose in life, and Jong for her depiction of heterosexually active feminist women. The combination could be explosive, like tossing ice cubes into a hot chip pan. My novel, in a somewhat safe (ie sealed) historical setting, is only a first attempt at bringing these two important strands of literary endeavour together.
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Ulco, de Ponce Vilma. "Thermodynamic properties of fluids & fluid mixtures. Abdulagatov, I.M.; Rabinovich, V.A.; Dvoryanchikov, V.I. Begell House Inc. Publishers New York 1999. 350 p." Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/101260.
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Yang, Xin. "Joint effects of VIP granting methods and non-VIP constomers' perceived similarity toward VIP customers on non-VIP customers' benign envy." HKBU Institutional Repository, 2015. https://repository.hkbu.edu.hk/etd_oa/232.
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In the service industry, preferential treatment is a popular strategic approach for retaining valued customers (e.g., Barnes, 1997; Gronroos & Ojasalo, 2004; Zabin & Brebach, 2004; Lacey, Russell, Jaebeom, & Morgan, 2007; Mattila, Hanks, & Zhang, 2013). However, some researchers argue that preferential treatment can lead to customer dissention toward the service firms (Fournier, Dobscha, & Mick, 1998). Marketers are reminded not to ignore the majority of less-profitable non-VIP customers, who have potential to be developed into valuable VIP customers in the future and contribute to firms’ economies of scale, total profits and healthy long-term growth (e.g., Zeithaml, Rust, & Lemon, 2001; Johnson & Selnes, 2005). The existing literature has mostly focused on negative responses (e.g., negative word-of-mouth, brand switching) of non-VIP customers in a preferential treatment context (Feinberg et al., 2002; Lehmann, 2001). However, positive responses of non-VIP customers in a preferential treatment scheme are largely neglected. Therefore, research on the positive responses from the majority of non-VIP customers is important for building a more complete theory of preferential treatment in this regard. In the current research, benign envy refers to a positive motivation derived from envy that compels the envious person to catch up with the envied person. Non-VIP customers with benign envy are more likely to have positive responses (e.g., treatment upgrading, positive word-of-mouth) toward the desired possession of other customers (i.e., VIP treatment). Investigating the antecedents leading to non-VIP customers’ benign envy of preferential treatment in the relationship marketing domain is a critical issue. Therefore, the primary objective of the current research is to investigate the antecedent conditions leading to non-VIP customers’ benign envy in preferential treatment (i.e., VIP treatment) contexts. To achieve my research objective of predicting benign envy of non-VIP customers, I first propose a popular market factor, the VIP granting method, as an antecedent variable influencing non-VIP customers’ benign envy (criterion variable). Specifically, I propose two types of VIP granting methods which have different impacts on benign envy of non-VIP customers toward VIP treatment. The current research theorizes that ascription-oriented VIP granting methods (e.g., birthdate, gender, kinship) and achievement-oriented VIP granting methods (e.g., accumulated consumption points, accumulated mileage, stipulated deposits) determine the choice of salient dimensions for comparison between non-VIP customers and VIP customers, which in turn determines the outcome of comparison (similar vs. dissimilar). The current research further investigates the mediation roles of perceived attainability and perceived deservingness to explain the psychological mechanisms that induce benign envy in non-VIP customers (Study 1). In addition, the current research examines the impact of cultural differences (ascription-oriented versus achievement-oriented) on perceived deservingness of VIP treatment by envied VIP customers (Study 2). The current research contributes to the marketing theory of preferential treatment in four respects. First, this research operationalizes the concept of benign envy as a motivation rather than an emotion to help explain and understand the controversial concept of benign envy in previous studies (e.g., Tai, Narayanan, & McAllister, 2012; Van de Ven, Zeelenberg, & Pieters, 2009). Second, drawing on the concepts of ascription and achievement in the discipline of sociology, the current research classifies conventional VIP granting methods into two categories based on customers’ ascribed attributes (e.g., birthdate) and achieved attributes (e.g., accumulated mileage). This classification helps both scholars and practitioners better understand the impacts of different VIP treatment strategies on non-VIP customers. Third, a theoretical model is proposed to predict benign envy. The proposed model contributes to the service literature with an in-depth understanding of psychological processes explaining how the benign envy of non-VIP customers is induced in the preferential treatment marketing context. Fourth, instead of drawing a holistic view on similarity as adopted in previous envy research and social comparison literature, the current research investigates the effects of similarity between the VIPs and non-VIPs from a more complex but realistic perspective. In this research, the upward social comparison which elicits envy was operationalized by similarity/dissimilarity along with two independent dimensions (ascription and achievement) instead of a unidimensional holistic perception. This operationalization allows the possibility that individuals will be similar in one dimension but dissimilar in another. The salient dimension of similarity between VIP customers and non-VIP customers thus can be triggered and manipulated by different VIP granting methods at the discretion of marketers. This advancement in the operationalization of similarity further contributes to envy studies and social comparison theory in the preferential treatment domain. Finally, the current research contributes to the theory of envy from a cross-cultural perspective and reveals a cultural boundary condition of the effect of perceived similarity on perceived deservingness of VIP treatment, which in turn influences the valence of envy. My findings showed that the effect of perceived similarity on perceived deservingness is more pronounced in achievement-oriented cultures than in ascription-oriented cultures. This is because ascription-oriented non-VIP customers (vs. achievement-oriented) tend to respect and value the ascribed attributes regardless of whether they are the actual beneficiary (i.e., similar to the VIP in personal salient attributes)
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Gerth, Michael. "Das ViP-Projekt." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-138091.
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Die Arbeitsgruppe E-Learning-Service startete im Sommersemester 2009 ein Pilotprojekt im Bereich Video-Podcasts (ViP), das seit dem Wintersemester 2010/11 in den Regelbetrieb übernommen wurde. Ohnen großen technischen Produktionsaufwand entstehen kostengünstige und für den Anwender nutzerfreundliche "E-Vorlesungen".
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Janhuba, Luboš. "Modifikace VOP letounu VUT100." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229464.
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The goal of the submitted Diploma Thesis is the Proposal of modifications of the horizontal tail (HT) of the plane VUT 100 by increasing the shoulder of HT and reduce of the HT surface. The Diploma Thesis consists of assessing the benefits of position adjustments, load calculation and the proposal of the basic design.
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Galuška, Ondřej. "Vymáhání pohledávek VZP ČR." Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-205298.
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This thesis deals with the enforcement of claims coming from public health insurance by VZP ČR. The work is divided into theoretical and practical part. The theoretical part describes the reasons for the claims on public health insurance, their findings through the administrative procedure and the legal possibilities of enforcement. It also contains a description of the bankruptcy and criminal proceedings. In the practical part is an analysis of enforcement of claims by VZP ČR from 2012 to 2015. The work also includes the definition of the organizational structure of the VZP ČR. In the final part of the thesis we identified shortcomings in the current working with claims by the VZP ČR.
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Amoedo, Machi Hugo [Verfasser], Gerhard [Akademischer Betreuer] Braus, Gerhard [Gutachter] Braus, Stefanie [Gutachter] Pöggeler, and Ralph [Gutachter] Kehlenbach. "The Aspergillus fumigatus Vap-Vip methyltransferase pathway modulates stress response, secondary metabolism and azole resistance / Hugo Amoedo Machi ; Gutachter: Gerhard Braus, Stefanie Pöggeler, Ralph Kehlenbach ; Betreuer: Gerhard Braus." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1190353644/34.
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Marie, Jean-Claude. "Caractérisation biologique et chimique du VIP monoiodé : mise en évidence du cycle du VIP et de la désensibilisation réversible par le VIP des cellules HT-29." Paris 6, 1986. http://www.theses.fr/1986PA066187.
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Tejaswi, Nunna. "Performance Analysis on Hybrid and ExactMethods for Solving Clustered VRP : A Comparative Study on VRP Algorithms." Thesis, Blekinge Tekniska Högskola, Institutionen för datalogi och datorsystemteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-14112.
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Context: The Vehicle Routing Problem is an NP-hard problem with a combination of varieties oftopics like logistics, optimization research and data mining. There is a vast need of vehicle routingsolutions in day to day like with different constraints. According to the requirements, this problem hasbeen a field of interest to a lot of researchers who incorporate scientific methods to combine andinnovate new solutions to optimize the routing. Being an np-hard problem, it is almost impossible tocompute the solutions to optimality but years of research on this area has paid off quite significantlyand the solutions are optimized little by little and better than before. Some applications may or maynot find slight difference in the performance as a considerable affect but some applications orscenarios heavily depend on the performance of the solution where it is very vital that the solution isoptimized to the fullest. As a data mining technique clustering has been used very prominently in caseof portioning scenarios and similarly it has also began to surface in implementing VRP solutions.Although it has recently emerged into the Vehicle Routing era and shown some significant results, ithas not yet come into an open state or awareness. The awareness regarding clustering matters in ahuge extent to be considered by most of the recent researchers who formulate new algorithms to solveVRP and help them further optimize their solution. Objectives: In this study the significance of clustering has been considered to find out how the usageof clustering techniques can alter the performance of VRP based solutions favorably. Then to test theresults of two recently proposed cluster based algorithms, a comparison has been made to other typesof algorithms which prove how the algorithms stand with various methods. Methods: A literature review is performed using various articles that have been gathered from GoogleScholar and then an empirical experiment was conducted on the results available in the papers. Thisexperiment was done by performing a comparative analysis. Results: For the literature review the results were gathered from all the articles based on theirresearch, experience, use of clustering and how their result was improved by using clustering methodsin their formulations. Considering the experiment, the results of both the algorithm were comparedwith the results of five other papers who aim to solve the VRP using exactly the same instances thatwere used in the two algorithms in order to compare valid results on the same variables. Then theresults were analyzed for the purpose of comparison and conclusions were drawn accordingly. Conclusions: From the research performed in this paper we can conclude the vast significance ofclustering techniques that were drawn based on practical test results of various authors. From theexperiment performed it is clear that the Hybrid algorithm has a much higher performance than anyother algorithm it has been compared to. This algorithm has also been proven to enhance itsperformance due to the implementation of clustering techniques in their formulation. Since the resultswere only based on performance that is, in this case the total distance of the final route, future studyindicates the implementation of algorithms to compare them on basis of time complexity and spacecomplexity as well.
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Belkin, Dmitrij. "Die Rezeption V.S. Solov'evs in Deutschland." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=963186256.
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Cader, Roshan. "V.S. Naipaul : homelessness and exiled identity." Thesis, Link to the online version, 2008. http://hdl.handle.net/10019/1446.
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Pabla, Rajvinder K. "Vision screening in preschoolers (VSP) study /." Adobe Acrobat Reader required to view document, 2009. http://www.neco.edu/library/theses/PablaThesisMay09.pdf.
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Mathialagan, Clint Solomon. "VIP: Finding Important People in Images." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/53706.
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People preserve memories of events such as birthdays, weddings, or vacations by capturing
photos, often depicting groups of people. Invariably, some individuals in the image are more
important than others given the context of the event. This work analyzes the concept of
the importance of individuals in group photographs. We address two specific questions -
Given an image, who are the most important individuals in it? Given multiple images of a
person, which image depicts the person in the most important role? We introduce a measure
of importance of people in images and investigate the correlation between importance and
visual saliency. We find that not only can we automatically predict the importance of
people from purely visual cues, incorporating this predicted importance results in significant
improvement in applications such as im2text (generating sentences that describe images of
groups of people).Master of Science
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Rebillas, Loredo Victoria. "The multi-depot VRP with vehicle interchanges." Doctoral thesis, Universitat Politècnica de Catalunya, 2018. http://hdl.handle.net/10803/664634.
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In real-world logistic operations there are a lot of situations that can be exploited to get better operational strategies. It is important to study these new alternatives, because they can represent significant cost reductions to the companies working with physical distribution. This thesis defines the Multi-Depot Vehicle Routing Problem with Vehicle Interchanges (MDVRPVI). In this problem, both vehicle capacities and duration limits on the routes of the drivers are imposed. To favor a better utilization of the available capacities and working times, it is allowed to combine pairs of routes at predefined interchange locations. The objective of this thesis is to analyze and solve the Multi-Depot Vehicle Routing Problem adding the possibility to interchange vehicles at predefined points. With this strategy, it is possible to reduce the total costs and the number of used routes with respect to the classical approach: The Multi-Depot Vehicle Routing Problem (MDVRP). It should be noted that the MDVRP is more challenging and sophisticated than the single-depot Vehicle Routing Problem (VRP). Besides, most exact algorithms for solving the classical VRP are difficult to adapt in order to solve the MDVRP (Montoya-Torres et al., 2015). From the complexity point of view, the MDVRPVI is NP-Hard, since it is an extension of the classical problem, which is already NP-Hard. We present a tight bound on the costs savings that can be attained allowing interchanges. Three integer programming formulations are proposed based on the classical vehicle-flow formulations of the MDVRP. One of these formulations was solved with a branch-and-bound algorithm, and the other two formulations, with branch-and-cut algorithms. Due to its great symmetry, the first formulation is only able to solve small instances. To increase the dimension of the instances used, we proposed two additional formulations that require one or more families of constraints of exponential size. In order to solve these formulations, we had to design and implement specific branch-and-cut algorithms. For these algorithms we implemented specific separation methods for constraints that had not previously been used in other routing problems. The computational experience performed evidences the routing savings compared with the solutions obtained with the classical approach and allows to compare the efficacy of the three solution methods proposed.En les operacions logístiques del món real es donen situacions que poden ser explotades per obtenir millors estratègies operacionals. És molt important estudiar aquestes noves alternatives, perquè poden representar una reducció significativa de costos per a les companyies que treballen en distribució de mercaderies. En aquesta tesi es defineix el Problema d'Enrutament de Vehicles amb Múltiples Dipòsits i Intercanvi de Vehicles (MDVRPVI). En aquest problema, es consideren tant la capacitat dels vehicles com els límits de duració de les rutes dels conductors. Per tal de millorar la utilització de les capacitats i temps de treball disponibles, es permet combinar parelles de rutes en punts d'intercanvi predefinits. L'objectiu d'aquesta tesi és analitzar i resoldre el problema d'Enrutament de Vehicles amb Múltiples Dipòsits, on es permet l'intercanvi de vehicles. Amb aquesta estratègia, és possible reduir els costos totals i el nombre de les rutes utilitzades respecte l'enfocament clàssic: el problema d'Enrutament de Vehicles amb Múltiples Dipòsits (MDVRP). Cal assenyalar que el MDRVP és més desafiant i sofisticat que el problema d'Enrutament de Vehicles d'un únic dipòsit (VRP). A més, molts algoritmes exactes per resoldre el VRP clàssic son complicats d'adaptar per resoldre el MDVRP (Montoya-Torres et al., 2015). Des del punt de vista de la complexitat, el MDRVPVI és NP-Dur, perquè és una extensió del problema clàssic, que també ho és. Presentem una cota ajustada de l'estalvi en els costos de distribució que es pot obtenir permetent els intercanvis. Es proposen tres formulacions de programació sencera basades en la formulació clàssica “vehicle-flow” del MDVRP. La primera formulació, degut a la seva grandària i la seva simetria, només permet resoldre instàncies molt petites. Per augmentar la dimensió de les instàncies abordables, es proposen dues formulacions addicionals que requereixen una o vàries famílies de restriccions de mida exponencial. Per això, per tal de resoldre el problema amb aquestes formulacions, ha calgut dissenyar i implementar sengles algorismes de tipus branch-and-cut. En aquests algorismes s'han implementat mètodes de separació específics per a les restriccions que no s'havien utilitzat prèviament en altres problemes de rutes. L’experiència computacional realitzada evidencia els estalvis obtinguts comparació amb les solucions corresponents l'enfocament clàssic. També es compara l’eficàcia dels tres mètodes propostes a l'hora de resoldre el problema.
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Piatkowska, Kinga. "Das Kino der VRP im DDR-Alltag." Doctoral thesis, Humboldt-Universität zu Berlin, Philosophische Fakultät III, 2011. http://dx.doi.org/10.18452/16429.
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Mit dem Ende des Zweiten Weltkrieges und mit der Proklamierung der DDR im Jahre 1949 wurde ein neues Kapitel in der Geschichte der deutsch-polnischen Beziehungen eröffnet. Die DDR und die Volksrepublik Polen wurden der Regierung der Sowjetunion unterstellt und als „Brüderländer“ aufgefordert, gegenseitige Kontakte in verschiedenen Bereichen zu pflegen. Eines von diesen Gebieten war auch das kulturelle Leben, von dem ein bedeutender Teil der Filmaustausch war. In den Jahren 1949-1990 wurden im Lichtspielwesen der DDR über 300 Spielfilme aus der Volksrepublik Polen verliehen, was zweifelsohne eine imposante Anzahl war. Die große Mehrheit dieser Filme wurde in der DDR-Presse rezensiert. 40 Jahre lang waren die Kritiken in Bezug auf das Filmangebot aus der Volksrepublik Polen im Lichtspielwesen der DDR ein fester Bestandteil der DDR-Alltags- und Kinopresse. Es sind innerhalb von dieser Zeit tausende von Rezensionen zu polnischen Filmen geschrieben worden, von deren ein großer Teil in dieser Arbeit analysiert wurde. Die Analyse der Pressebeiträge stellt ein Bild der Beurteilungen der polnischen Produktionen durch die DDR-Journalisten dar, lässt aber auch ganz genau Änderungen in den Beziehungen zwischen der Volksrepublik Polen und der DDR in den Jahren 1949-1989 erkennen. Dadurch bildet die politische Situation in den beiden Nachbarländern den Hintergrund dieser Arbeit, wobei fünf wichtige geschichtliche Phasen ausgewählt werden, die die Kapitel der Arbeit bilden. Zwei Unterkapitel dieser Arbeit werden der Rezeption der Filme von zwei bedeutendsten polnischen Regisseuren der Nachkriegszeit gewidmet: Andrzej Wajda und Krzysztof Zanussi.With the end of the Second World War, and the formation of the DDR in 1949, a new chapter in the history of German-Polish relations began. The DDR and the People''s Republic of Poland were placed under the control of the Soviet Union, and as “brother lands” were encouraged to foster a mutual contact and exchange in various areas. One such area of exchange was in cultural life, of which a significant part was the sharing of films from both countries. In the years 1949-1990 over 300 Polish films were distributed in East German cinemas, an indisputably significant figure. The great majority of these films were reviewed in the DDR press, and in fact reviews of the cinematic offerings from the People''s Republic of Poland formed a regular component of East German newspapers during this period of 40 years. Over this time, thousands of reviews of Polish films were written, a large number of which are analysed in this dissertation. The analysis of press articles forms a picture of how Polish film productions were regarded by DDR journalists, but also reveals the changing relationship between the two countries in the period from 1949 to 1989. Thus the political situation in these neighbouring countries forms the background of this dissertation, with each chapter discussing one of five important historical phases. Two sub-chapters of this dissertation are devoted to a discussion of the East German reception of the films of Andrzej Wajda and Krzysztof Zanussi – two of Poland''s most important post-war directors.
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Kotrč, Ondřej. "Budova VZP ČR Jihlava - stavebně technologický projekt." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2012. http://www.nusl.cz/ntk/nusl-225379.
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The aim of the diploma thesis is a constructional and technological project of regional branch VZP in the town Jihlava. The project includes a building site outfit, technological rule for prefabricated skeletel constructions, budget, time schedule, kontrol and test plans, design of machine works, contract for work and safety report. As a part of the diploma thesis is also confrontation contact heta cladding system and heat cladding system with a ventilated air gap. The last supplement is safety report at demolitions.
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Šrůtek, Michal. "Určení aerodynamických charakteristik VOP letounu CFD metodou." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228062.
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Tutaya, Zevallos Roxana María. "Plan de marketing para Vip Dating Perú." Master's thesis, Universidad del Pacífico, 2015. http://hdl.handle.net/11354/1204.
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El Plan de Marketing propuesto tiene como objetivo establecer la forma de expansión y comunicación de la empresa Vip Dating Perú en el territorio peruano. Para ello, se realizó una investigación de mercado que ayudó a concretar cuáles son las preferencias y el conocimiento que existe de nuestro público objetivo. Asimismo, esta investigación revela que Vip Dating Perú tiene potencial de crecimiento y la marca goza de muy buena aceptación. En lo que se refiere a la estrategia de crecimiento, se determinó expandir las operaciones a las principales ciudades del Perú, Arequipa y Trujillo, realizando un número determinado de eventos por año en cada una de ellas. Por tal motivo, en mayo del 2015 se inició la campaña de promoción y publicidad en Arequipa. Hubo una gran acogida por parte de los medios de comunicación puesto que el servicio es bastante novedoso para la ciudad. Finalmente, el diagnóstico situacional revela más oportunidades y fortalezas que amenazas y debilidades, lo que genera un entorno favorable para el desarrollo del negocio. Esto se verá plasmado en la formulación estratégica de marketing que guiará el logro de los objetivos propuestos.
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Jones, Nicole Maria, and Nicole Maria Jones. "VAP Prevention Knowledge in the Emergency Department." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/624492.
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Introduction: Ventilator associated pneumonia (VAP) is a prevalent hospital acquired infection that patients have a risk of developing after being intubated. The mortality rate of intubated patients is estimated between 30-50 percent. Furthermore, it is estimated that VAP occurs in 10-30 percent of all intubated patients. Numerous studies have linked VAP protocols and evidence based guidelines initiated in the intensive care unit (ICU) to a decrease in the prevalence of VAP. However, limited research exists on VAP prevention protocols implemented in the emergency department (ED). Early implementation of VAP bundles and protocols are linked to a decrease in the prevalence of VAP.
Purpose: Evaluate the knowledge of interdisciplinary staff members on VAP, and the VAP prevention protocol in the emergency department.
Setting: The setting of the DNP project is a 61-bed level one trauma emergency department at a Banner University Medical Center, serving approximately 77,000 patients a year.
Results: The average score VAP survey was a 71.6%, with majority of the respondents unable to identify the correct patient diagnosed with VAP. The major barriers identified by the survey included lack of education, availability of the necessary supplies, proper orders to be imputed by providers, patient availability, lack of time and/or supplies, and RN ratios.
Discussion: The results of the survey show majority of the registered nurses are not familiar with the protocol, but suggest they do implement the protocol on those patients who are intubated in the ED. Thus, there are still gaps in the full implementation of the VAP protocol and there is a need further improvement in the care of patients who are intubated in the ED.
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Zeng, Xinwu. "Shear-wave VSP data processing for anisotropy." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/13250.
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It has now become comparatively common in shear-wave exploration to use the measurements of the polarization direction of the leading shear-wave and the travel-time delay between this and the slow split shear-wave, to give a direct indication of the orientation and strength of anisotropy. It is important to investigate and develop suitable techniques to extract these parameters from seismic data. To investigate the anisotropic properties of shear-wave propagating in anisotropic medium, I first develop a vector convolutional model for a shear-wave propagating through an anisotropic medium in Chapter 2. Based on this unified model, four algebraic processing techniques have been developed to estimate the shear-wave polarisation and time-delay for near-offset VSPs. The techniques include both cumulative and interval techniques for either dual/multi or single sources data. These techniques are algebraic exact solutions, faster than any possible numerical equivalent, and robust to noise. Uncertainties in the ground coupling of shear sources, alignment of the source polarization, the transfer function between the geophone and the formation, and the orientation of the receiver tool in the borehole, may be amongst the principal causes of inaccuracy when estimating shear-wave splitting from multicomponent near-offset VSP data. In Chapter 3, investigations using synthetic seismograms computed for a zero-offset VSP in an anisotropic half-space, address the frequency independent part of this problem to determine how much uncertainty can be tolerated for simple amplitude and orientation variations in the source and geophone components, while still maintaining a shear-wave polarization estimated for the faster split shear-wave accurate to within 5°.
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Rosa, Pedro Henrique Alves da. "Comportamento do telespectador do big brother VIP." Master's thesis, Instituto Superior de Economia e Gestão, 2013. http://hdl.handle.net/10400.5/11443.
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Mestrado em MarketingAs emissoras de televisão sustentam o seu negócio na entrega de audiências aos anunciantes. Conhecer o comportamento do telespectador permite desenvolver melhor a oferta televisiva, alcançar maiores audiências e aumentar o valor que os anunciantes estarão dispostos a pagar pela sua atenção. Esta investigação aborda um programa do género reality show, o qual consiste na exposição da vida de outras pessoas, com o propósito de entreter o espectador. Em Portugal, o programa Big Brother acabou com a hegemonia da SIC sobre o mercado televisivo português e ajudou a consolidar a programação da TVI, tornando o terceiro player do mercado no líder nacional. Hoje, estas duas maiores empresas de televisão batalham novamente pela liderança de audiências no mercado em horário nobre. O Big Brother VIP foi a maneira que a TVI encontrou para competir com a bem-sucedida novela Dancin' Days, da SIC. Este estudo permitiu perceber que o consumidor pretende gratificar as suas necessidades por autenticidade e voyeurismo. Gosta de comédia e interacção social entre concorrentes e abomina manipulação. Foi ainda analisado o comportamento do espectador regular, o que influencia o consumo das Galas de Expulsão e de Nomeações e o que condiciona as gratificações do espectador ao ver o programa. Identificaram-se, ainda, quatro perfis do consumidor e o concorrente ideal foi descrito como sendo leal, sociável e divertido, preocupado com o bem-estar do grupo, curioso, ambicioso, orientado para a família, que não dependa de terceiros para ser feliz, saiba viver humildemente, saudável, ascético, com tendências igualitaristas, auto-confiante e cooperante.
Television broadcasting companies sustain their business by delivering audiences to advertisers. Knowing audience behavior allows them to better develop the television offer, to attain higher audiences and to increase the value marketers are willing to pay for televiewers attention. This research approaches a reality show television programme which aims to explore the lives of other people in an entertaining manner for the viewer. Portuguese Big Brother ended up with SIC's hegemony over the portuguese television market and helped to consolidate TVI's schedule based on popular information and national drama fiction (novella) which turned the third television player into the national leader. Today these two biggest broadcasting companies are again battling over leadership of primetime's ratings. Big Brother VIP was the way that TVI found to compete against the well succeeded SIC's novella Dancin' Days. This study allowed to access the way the televiewer reacts to the show and made it possible to understand that the consumer wants to gratify its authenticity and voyeuristic needs. He/she likes comedy and social interaction between contestants and abominates manipulation. The results allowed to understand the regular viewer's behavior, what makes people watch the eviction and nominating shows and what influences the gratifications sought by watching the show. There were obtained four viewer profiles as well and the ideal contestant was defined as loyal, sociable and funny, concerned with others well-being, curious, ambitious, family-oriented, don't depends on others to be happy, humble, healthy, ascetic and denotes egalitarian tendencies.
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NICOLE, PASCAL. "Les recepteurs humains du vip, vpac 1 et vpac 2 : mutagenese dirigee, chimerisme moleculaire et alanine-scanning du vip." Paris 11, 2000. http://www.theses.fr/2000PA112332.
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Le peptide intestinal vasoactif (vip) joue un role regulateur important dans tout l'organisme. Le but du travail de recherche presente ici est l'analyse de la relation structure-fonction du vip et de ses recepteurs humains vpac 1 et vpac 2. Les recepteurs vpac appartiennent a une sous-famille originale de la super-famille des recepteurs couples aux proteines g (rcpg), la famille de classe ii. Cette sous-famille se caracterise notamment par une extremite n-terminale extracellulaire tres longue, superieure a 120 acides amines, siege de la fixation du ligand. Les etudes menees au cours de cette these se repartissent en trois parties : 1) etude de la relation structure/activite du vip pour interagir avec les recepteurs vpac 1 et vpac 2 humains. Chaque residu du vip est remplace individuellement par un residu alanine (ala-scan). Les differents peptides obtenus par synthese chimique ont ete testes par inhibition competitive de la liaison de vip radiomarque ( 1 2 5i-vip) aux recepteurs recombinants vpac 1 et vpac 2. Les resultats ont montre que les residus importants pour la liaison du vip se repartissent tout du long de la molecule de vip. Ce travail a permis de developper le premier analogue selectif du recepteur vpac 1 humain : ala 1 1 , 2 2 , 2 8-vip. 2) etude de la relation structure/activite des recepteurs humains vpac 1 et/ou vpac 2. Des techniques de mutagenese dirigee et de transfection transitoire des mutants dans des cellules cos-7 et cho en culture ont permis de mettre en evidence le role de differents residus au niveau des recepteurs vpac 1 et vpac 2 dans la reconnaissance du vip. Les resultats obtenus renforcent l'importance du role des domaines extracellulaires (n-terminal et boucles i et ii) dans la liaison du vip. Ces travaux ont permis, par ailleurs, de developper et de valider un modele 3d du domaine n-terminal du recepteur vpac 1 humain. 3) etude de la difference de selectivite pharmacologique du recepteur vpac 1. Nous avons demontre par chimerisme moleculaire et mutagenese dirigee que la selectivite pharmacologique des recepteurs humains et de rat envers un peptide de la meme famille que le vip, le phi, est portee par trois acides amines non-adjacents de la 1 e r e boucle extracellulaire et du 3 e m e domaine transmembranaire. Ce domaine est different du domaine majeur de reconnaissance du vip, le domaine n-terminal.
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Aliu, Jeton, and Ledia Youkhanis. "Energieffektivisering genom ombyggnad : Med hjälp av VIP-Energy." Thesis, KTH, Byggteknik och design, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-121972.
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Detta examensarbete har genomförts i samarbete med Värmex AB där vi har haft Anders Ericsson som handledare, och Peter Hansson (Sweco) som handledare från skolan, Kungliga tekniska högskolan i Haninge. Idag är energianvändningen i flerbostadshus en stor fråga att ta itu med, och för varje byggnadsprojekt skall en energideklaration som visar mängd köpt energi göras. Vi strävar idag efter att minska energianvändningen i flerbostadshus med 50 % till 2050. I denna analys beskriver vi vilka åtgärder man kan ta an för att minska just energianvändningen i ett specifikt flerbostadshus belägen i kommunen Nacka i Stockholm. Då denna byggnad stått från år 1949 utan större underhållning har det visat sig att byggnaden står över BBRs krav gällande energianvändning (90 kWh/m2), och stor anledning är klimatskalet. Källor visar även att delar av klimatskalet så som fasad etc. bör ändras inom 30 år efter det att det byggts, vilket inte har gjorts. Vi har genom en programvara, VIP-Energy valt att utföra denna analys. Med hjälp av offentliga handlingar från stadsbyggnadskontoret så som plan – sektion – fasadritningar har vi mätt nödvändiga mått som vi knappat in i programmet. Även information som byggnadsmaterial, läge på byggnaden och uppvärmningssystem har varit nödvändiga. Jämförelse mot BBRs krav har gjorts automatiskt i programmet och det är sådan slags information vi utgått ifrån. Då vi i denna analys valt att fokusera på klimatskal där tak, golv, väggar, fönster och dörrar ingår visar resultatet att lägre u-värden på byggnadsdelar bidrar till lägre energianvändning. Studier visar att ca 35 % av värmeförlusterna är via fönster, och detta överensstämmer med byggnaden som denna analys är baserad på. Som lösning till detta har vi valt att byta fönster till 2-glas fönster med isolleruta vilket har betydligt lägre u-värde än de vi har idag. Vi vill även förbättra karmen och fogen kring fönstren för att minska transmissionsförlusterna och eventuella drag i bostäderna, vilket i sin tur leder till bättre komfort och skönare atmosfär. Detsamma gäller yterdörrarna som behöver bytas för att hålla värmen inne. Utvändig isolering i ytterväggen bidrar även med förbättringar kring u-värde och energianvändning. Originalhuset visade att byggnadens genomsnittliga U-värde ligger på 0,656W/m2K och energianvändningen ligger på 96 kWh/m2 per år. Enligt BBRs krav för äldre byggnader ska u-värdet ligga på 0,400W/m2K och energianvändningen på 90kWh/m2 per år. Energibalansberäkningen visar nya värden på byggnaden, vilket är totala u-värde på 0,409 W/m2K samt energianvändningen på 64 kWh/m2.This degree project has been written in collaboration with Värmex AB, with the generous help of Anders Ericsson as our fellow adviser and Peter Hansson (Sweco) our mentor from the Royal institute of technology located in Haninge. Today we find questions pertaining to energy consumption in apartment blocks of real significance; with each building project a declaration that shows the amount of energy consumed is of outmost importance. We strive to reduce energy consumption in apartment blocks by 50 % until year 2050. In this degree thesis, we aim to describe measures and solutions to lower the consumption of energy in a specific apartment block located in Nacka, Stockholm. This building has been standing quite untouched and unmarked since 1949, yet it is still in compliance with the demands stated by BBR concerning energy efficiency, in large because of its climate shell. Sources show that greater parts of its outer shell for example the front, should have been repaired during the first 30 years, and the matter is still to be solved. The use of a computer software VIP-Energy has enabled us to state a hypothesis. With the help of public documents from Housing And Urban Development Town Building Office (HUD) giving us an overview of the different dimensions of the building, we've been able to plot all this data into the software. Information such as building materials, location, heating systems have also been necessary in our analysis. Results are automatically compared to the demands required by BBR. It is through experimentation of this data that we have been successful in collecting our results. In the analysis, we chose to focus on the climate shell that constitutes: roof, floors, walls, windows and doors. Our results show that lower U-values conduce better energy efficiency. Studies show that almost 35 % of energy loss in a building is caused by the windows of the building, this this is consistent with the building which this analysis is based on. We have solved this by changing sheet glass that is energy efficient. We also aim to change the frame and seams surrounding the windows, in order to lower transmission losses and possible draughts in the apartments. This will result in hopefully a higher degree of comfort and refreshing atmosphere. The same changes apply to entry doors in order to keep energy loss to a minimum. Also an external insulation in the outer wall contributes to improvements on u-value and use. The original building shows an average U-value of 0,656W/m2K and the energy consumption is 96 kWh/m2 per year. According to BBR, older buildings should have a U-value of 0,400W/m2K and an energy consumption of 90kWh/m2 per year. Energy balance calculation show new values for the building were the u -value should be set to 0,409W/m2K, and energy consumption should be set to 64kWh/m2.
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Karūžaitė, Rasa. "Kompleksinė specialioji pagalba integruotai ugdomiems vaikams sergantiems VCP." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050615_154800-60403.
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Education reform changes taking place in Lithuania, one of the main tasks of this reform became the reorganization of education of children with special needs. The reorganization of special education changes not only the state of children with special needs but also the whole educational system. The isolation of these children that existed before the reorganization objected the principle of equal learning opportunities.
The accepted child’s birthright to live in his/her own family, to be brought up in familiar environment which meets his/her needs. It became the main assumption of disabled children integrated learning at secondary schools.
More and more children, having cerebral palsy (CP), are being educated at secondary schools. Despite big attempts to create optimal conditions for educating these children, it is not always successful. The author of this work was interested in difficulties that children of this category, their pedagogues, parents and classmates meet with, when these children are educated to integrate into secondary schools.
Aim of research: to view and to evaluate providing complex help to children, having CP, integrating into secondary schools.
Object of research: education of children having children cerebral paralysis at integrated secondary schools.
Aims of research:
1. Evaluate special educational needs of children who took part in this research.
2. To find out the breaches of educating children with CP at secondary schools.
3. Referring to... [to full text]
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Maultzsch, Sonja. "Analysis of frequency-dependent anisotropy in VSP data." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/808.
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The use of seismic anisotropy for the characterization of fracture systems in the subsurface is based upon equivalent medium theories that describe the average elastic response of a fractured material in the long wavelength limit. Traditional equivalent medium models predict a seismic response that is independent of frequency and insensitive to the size of the fractures. Recent observations from seismic data challenge these assumptions. The interpretation of attenuation and velocity dispersion in laboratory data acquired in the kHz to GHz frequency range is based on the concept of squirt flow in porous fluid-saturated rock. A number of studies have also found effects of dispersion in the seismic frequency band, particularly in connection with fracture zones. However, these observations have been lacking quantitative explanation in terms of petrophysical processes, and with regard to wave-induced fluid motion in porous rock seismic data are generally assumed to represent the low frequency limit. Recent work on equivalent medium theories for fractured rock address these issues by incorporating wave-induced uid motion into the modelling, which predicts seismic anisotropy to depend on frequency. I analyse VSP data from five different sedimentary basins that contain naturally fractured hydrocarbon reservoirs. I design processing techniques to investigate whether frequency-dependent anisotropy can be detected in the seismic frequency band. I find broad evidence in support of the concept. Three different attributes are extracted from the data that give evidence of anisotropic dispersion: P-wave attenuation anisotropy, the frequency dependence of the time delay between split shear waves, and attenuation of the slow shear wave compared to the fast one. The measured effects correlate with information on the presence of fractures in the reservoirs of the respective oil and gas fields. For one of the data sets where no anisotropic dispersion is detected, fracture-induced anisotropy is very weak and dominated by polar anisotropy. The observations can be explained by a squirt-flow model for fractured rock. The sensitivity of the modelled response to fluid type and fracture length scales is consistent with the real data results and geological evidence. It may not always be possible to detect frequency-dependent anisotropy in real data depending on data quality and the symmetry of the equivalent anisotropic medium. Nevertheless, the quantitative evidence of anisotropic dispersion from the majority of the VSPs and the correlation with the presence of fractures in the subsurface suggest that it is worthwhile considering these effects in analyses of seismic anisotropy.
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Couvineau, Alain. "Le Récepteur du VIP analyse pharmacologique et structurale." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37596925b.
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Söderlund, Petra. "Romantik och förnuft : V.F. Palmblads förlag 1810-1830 /." Uppsala : Gidlunds, 2000. http://catalogue.bnf.fr/ark:/12148/cb409308763.
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Prescott, Lynda. "Reading V.S. Naipaul : fiction and history, 1967-1987." Thesis, n.p, 1990. http://ethos.bl.uk/.
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Chao, Lily. "Dr. V.K. Wellington Koo and the Washington Conference /." [Hong Kong : University of Hong Kong], 1987. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12352342.
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Almonte, M. Alejandro, L. Ernesto Fairlie, I. Héctor Munita, and G. Mario Ruiz. "Vip´s reposición para pequeñas y medianas empresas." Tesis, Universidad de Chile, 2005. http://repositorio.uchile.cl/handle/2250/114243.
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Tesis para optar al grado de Magíster en AdministraciónNo disponible a texto completo
El punto de venta no es sólo un lugar donde se exhiben los productos, sino que es el sitio donde se toman muchas de las decisiones de compra y por ello cualquier variable que afecte esta decisión modifica el resultado de una compañía. Los supermercados preocupados de este tema, exigen a sus proveedores Reponedores o Mercaderistas, que se encargan de llevar los productos desde la bodega a las góndolas, con lo cual aseguran que el producto esté siempre disponible y además en línea con las estrategias definidas para el producto. Las empresas pequeñas y medianas que ofrecen activamente sus productos a un supermercado sobrepasan las 3.000, y dada sus capacidades, no alcanzan a cubrir apropiadamente todos sus puntos de ventas, ya que significan costos relativamente altos en comparación con sus ventas. Actualmente, en el mercado de la reposición, sólo se ofrece servicios de outsourcing de personal, y no están diseñados para satisfacer las necesidades de las pequeñas y medianas empresas, es por eso que, a través de una estrategia de focalización, crearemos un nuevo concepto en Chile, que es el de la entrega de servicios de reposición integral, especializado en este tipo de empresas, que se caracteriza por el control del servicio, flexibilidad e información desde el punto de venta. A través de este concepto aseguramos diferenciación en el mercado ya que son cualidades difíciles imitar, por las fuertes barreras de entrada que implica tener un sistema como éste, logística interna compleja, sistemas de información sofisticada e inversión inicial elevada. Bajo este nuevo concepto, ofreceremos servicios innovadores como son reposición por hora, el cual podrá aumentar o disminuir de acuerdo a las necesidades del cliente; procedimientos estandarizados, supervisión de mercaderistas, sistemas de información en línea desde el punto de venta, para que el cliente tome de decisiones en el momento; y una única modalidad de cálculo de tarifas, que permite ordenar las cuentas a nuestros clientes. El servicio asegura que ellos no absorberán las ineficiencias como tiempos de traslado o vacaciones, o gastos imprevistos como finiquitos. Para poner en marcha el negocio, nuestro equipo cuenta con todas las habilidades y especialidades necesarias, que en conjunto nos catapultarán al éxito. El proyecto, alcanzará un VAN de MM$ 1.572 en 5 años a una tasa de descuento del 33%, con una inversión inicial de MM$ 285. Se proyecta que el payback se alcanzará antes del mes 15 y el punto de equilibrio en el 5°. Para poder tener VAN positivos, necesitamos 12 clientes, podremos absorber hasta el 21% de caídas de precios y aguantar aumentos de costos de hasta un 30%. El mercado potencial de este negocio alcanza los MMUS$ 26 sólo en la Región Metropolitana, para poder atenderlo, necesitamos socios que deseen compartir el éxito con nosotros. Queremos que forme parte de nuestro equipo, participando de hasta un 49% propiedad, lo que equivale a MM$ 140 de Inversión Inicial. Por cada peso que invierta recibirá $2.5 de ganancia a valor presente, para lograrlo le aseguramos nuestro compromiso económico y dedicación total.
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Gerth, Michael. "Das ViP-Projekt: Videovorlesungen an der Universität Leipzig." Hochschuldidaktisches Zentrum, 2011. https://ul.qucosa.de/id/qucosa%3A12358.
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Die Arbeitsgruppe E-Learning-Service startete im Sommersemester 2009 ein Pilotprojekt im Bereich Video-Podcasts (ViP), das seit dem Wintersemester 2010/11 in den Regelbetrieb übernommen wurde. Ohnen großen technischen Produktionsaufwand entstehen kostengünstige und für den Anwender nutzerfreundliche "E-Vorlesungen".
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Roberts, Mark Alvin. "Full waveform inversion of walk-away VSP data." Paris, Institut de physique du globe, 2007. http://www.theses.fr/2007GLOB0020.
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Du fait de l’épuisement des réserves de pétrole, l’exploration et la production sont réalisées dans des environnements de plus en plus complexes. Faire de l’imagerie sismique sous le sel allochtone (par exemple dômes de sel) demeure une tâche difficile à cause du fait contraste de vitesse dentre le sel et les sédiments voisins et les structures très complexes produites par les déplacements de sel. Les nappes de sel allochtone couvrent de nombreuses régions potentiellement productives dans l’offshore profond du Golfe du Mexique. Forer la base du sel est une tâche extrêmement difficile en raison des pressions de pore fortement variables que l’on recontre dans les sédiments sous le sel. Des méthodes sismiques pour estimer la vitesse des ondes sismiques peuvent être employées en même temps que des formules empiriques pour prévoir la pression de pore. Cependant, il est souvent impossible de mesures précises depuis la surface, et nous avons donc employé des données VSP (Vertical Seismic Profile) “walk-away” cela implique d’effectuer plusieurs tirs sismique à diverses distances du forage (géneralement avec un dispositif de canons á air) tout en enregistrement les vitesses mesurees par des geophones placés à des profondeurs appropriées dans le forage. Avant cette thèse, les données étaient traitées en utilisant l’information d’amplitude en fonction de l’angle dans un simple approximation 1D ou en utilisant l’information de temps de parcours (également avec une approximation 1D). Dans cette thèse, j’ai effectué une inversion 2D de forme d’onde pour résoudre le problème d’estimation des vitesses. Cela a l’avantage d’inverser simultanément l’ensemble des données (comprenant les ondes transmises, les ondes refléchies et les ondes converties) et la méthode inclut l’information de temps de parcours et d’amplitude. L’inversion a été exécute avec des méthodes locales d’inversion du fait de la taille du problème inverse et de la difficulté du problème direct. Les problèmes liés aux grandes variations de le sensibilité inhérents à l’acquisition de données, ont conduit à un examen de la méthode de Gauss- Newton et à des matrices, de préconditionnement possibles pour la méthode du gradient conjugué. En raison de la nature mal contrainte du problème inverse, une régularisation a été appliquée avec une méthode de préconditionnement innovatrice. La méthodologie a été appliquée à des données réelles et la pression de pore a été prédite en utilisant l’équation bien établie de Eaton. En outre, les structures sous le sel ont été déterminées, confirment ainsi l’efficacité de cette techniqueDepletion of the earth’s hydrocarbon reserves has led to exploration and production in increasingly complex environments. Imaging beneath allochthonous salt (e. G. Salt domes) remains a challenging task for seismic techniques due to the large velocity contrast of the salt with neighbouring sediments and the very complex structures generated by salt movement. Extensive allochthonous salt sheets cover many potentially productive regions in the deep-water Gulf of Mexico. Drilling through the base of salt is an extremely challenging task due to widely varying pore-pressure found in the sediments beneath. Seismic methods to estimate the seismic velocity can be used in conjunction with empirical formula to predict the pore pressure. However, accurate measurements are often not possible from surface reflection seismic data, so walk-away Vertical Seismic Profile (VSP) data has been used. This involves repeatedly firing a seismic source at various distances from the borehole (usually an airgun array) while recording the velocities measured by geophones in the borehole placed at appropriate depths near the base of the salt. Before this thesis, the data had been processed using the amplitude versus angle information in a simple one-dimension approximation or using travel time information (also using a 1D assumption). In this thesis, I have used 2D full waveform inversion to tackle the problem of velocity estimation. This has the advantage of simultaneously inverting the whole dataset (including transmitted waves, reflected waves, converted waves) and the method includes traveltime and amplitude information. The inversion was performed using local inversion methods due to the size of the inverse problem and the cost of the forward problem. Concerns over large sensitivity variations, that are inherent in the data acquisition, have lead to an examination of the Gauss-Newton method and possible preconditioning matrices for the conjugate gradient method. Due to the poorly constrained nature of the inverse problem, a smoothness constraint has been applied with an innovative preconditioning method. The methodology has been applied to real data and the pore pressure has been predicted using the well established Eaton equation. In addition, the sub-salt structure was recovered, further demonstrating the value of this technique
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Couvineau, Alain. "Le recepteur du vip : analyse pharmacologique et structurale." Paris 6, 1986. http://www.theses.fr/1986PA066364.
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Bensalma, Souheyla. "Voie Hedgehog et système VIP-récepteurs dans des cellules de glioblastome." Thesis, Poitiers, 2013. http://www.theses.fr/2013POIT2317/document.
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La forme la plus agressive des gliomes, tumeurs cérébrales primitives, est l'astrocytome de grade IV appelé aussi glioblastome (GBM). Le pronostic des patients atteints d'un GBM est très sombre du fait de la nature infiltrante de ces cancers et de la présence de cellules souches cancéreuses (CSC) peu sensibles aux thérapies actuelles. Il est donc primordial d'étudier ces deux caractéristiques des GBM. Mes travaux de thèse ont porté sur ces deux aspects.La connaissance de l'implication de la voie de signalisation Hedgehog (Hh) dans le maintien du pool de CSC permet d'envisager de nouvelles stratégies thérapeutiques visant à les éliminer. La voie Hh joue un rôle important dans le développement embryonnaire. L'activation de cette voie a été mise en évidence dans de nombreux cancers dont les GBM. La cyclopamine est une substance alcaloïde inhibitrice de la voie Hh. L'inconvénient de l'utilisation de la cyclopamine pour une thérapie anticancéreuse est que cette voie est aussi active dans les cellules souches somatiques adultes. Pour cibler la tumeur, une prodrogue glucuronylée de la cyclopamine a été synthétisée. La partie glucuronide peut être hydrolysée par la β-glucuronidase, une enzyme présente dans la zone nécrotique des GBM, conduisant à la libération de la cyclopamine active de façon ciblée, dans le microenvironnement tumoral. Des tests de viabilité indiquent que cette prodrogue ne présente pas latoxicité de la cyclopamine envers les cellules C6 de GBM de rat, leur population de cellule souches (C6-GSC) ainsi que dans des coupes de cerveau de rat adulte. En revanche, l'hydrolyse par la β-glucuronidase de cette prodrogue permet de restaurer la toxicité de la cyclopamine sur les cellules de GBM. L'analyse par RT-qPCR de l'expression d'un gène cible de la voie Hh, le facteur de transcription GLI1, permet de vérifier l'inhibition spécifique de la voie Hh par la cyclopamine dans les cellules C6 et les C6-GSC. Ainsi, la prodrogue en libérant la cyclopamine dans l'environnement tumoral devrait permettre de limiter l'étendue des effets de la drogue sur les cellules saines du cerveau.La voie Hh joue un rôle dans la régulation de la migration et de l'invasion des cellules de GBM. Mon équipe d'accueil a montré que le vasoactive intestinal peptide (VIP) régule la migration et l'invasion de deux lignées cellulaires M059K et M059J. Dans ce travail de thèse, les effets du VIP et de son analogue le pituitary adenylate cyclase-activating peptide(PACAP) sur la migration et l'invasion des cellules C6 de rat et U87 humaines ont été étudiés. Les résultats obtenus indiquent que les agonistes VIP, PACAP-38 et l'antagoniste synthétique VIP10-28 des récepteurs de ces peptides contrôlent la migration et l'invasion dans les deux lignées de GBM. Le VIP et le PACAP-38 inhibent l'invasion ex vivodes cellules C6 dans des coupes de cerveau. De plus, le VIP10-28 augmente la migration et l'invasion de ces cellules de façon PKA-, Akt- et Hh-dépendante. L'étude des voies detransduction impliquées dans l'action des neuropeptides sur la migration et l'invasion des GBM a ensuite été approfondie. Les données obtenues indiquent que le VIP et le PACAP diminuent le taux de la forme active nucléaire de la protéine GLI1 dans les cellules C6 et U87 de façon PKA-dépendante. Inversement, le VIP10-28 augmente l'expression de GLI1 dans les cellules C6 de façon Akt-dépendante. Enfin, nous avons constaté que le PACAP diminue la phosphorylation d'Akt dans les cellules C6 etaugmente celle de la protéine PTEN, en accord avec le rôle de ces kinases dans la régulation de la migration cellulaire et de l'activité GLI1. L'ensemble de ces résultats indique que le système VIP-récepteurs régule la migration et l'invasion par des interactions entre les voies PKA, Hh et Akt/PTEN dans les cellules de GBMThe most aggressive form of glioma, primary brain tumors, is grade IV astrocytoma also called glioblastoma (GBM)
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Ružička, Vladimír. "Aplikace problému Obchodního cestujícího v reálném prostředí distribuční společnosti." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2012. http://www.nusl.cz/ntk/nusl-236578.
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This paper deals with optimal distribution issues. One may find listed problems of real life linked to distribution. Moreover, there are explained travelling salesman problem, vehicle routing problem and its variants. This work brings an overview of different ways how to solve vehicle routing problem. In practical part, there is an analysis of distribution of real company. The concept of application is presented in the second part of this paper. This concept could reduce costs of distribution in analyzed company. Testing is aimed mainly on the variant VRPCL (Vehicle Routing Problem with Continuos Loading).
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Nebrija, Antonio de González Vega Felipe. "Aurelii Prudentii Clementis V.C. libelli cum commento Antoni Nebrissensis /." Salamanca : Ed. Universidad de Salamanca, 2002. http://catalogue.bnf.fr/ark:/12148/cb41072787c.
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Wagnerová, Hana. "Posílení konkurenceschopnosti účetního střediska Pneuservis ve VOP GROUP, s.r.o." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2014. http://www.nusl.cz/ntk/nusl-224588.
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This diploma thesis deals with strengthening of competitiveness of the accounting centre “Pneuservis” in the VOP GROUP, s.r.o., which currently faces financial problems and lacks enough competitiveness. Proposals have been outlined on the basis of the strategic analysis. The competitive strategy has been developed for Pneuservis VOP GROUP, s.r.o., the part of which has been the formulation of vision, mission and strategic goals. The objective has been defined as acquisition of new customers and, consequently, strengthening of competitiveness of Pneuservis VOP GROUP, s.r.o..
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Pevný, Ondřej. "Příprava a organizace výstavby Krajské pobočky VZP v Jihlavě." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2017. http://www.nusl.cz/ntk/nusl-265250.
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Abstract The aim of this thesis is the preparation of the building and technological project of the regional department of the company VZP CR in Jihlava. The content of this thesis is the elaboration of technological regulations for reinforced concrete and prefabricated skeleton and for monolithic external walls. The quality and characteristics of these constructions are solved in the controlled and test plans. Site facilities including occupational safety and health,transport routes for transporting of materials and traffic around the site are addressed in detail in the next section of this thesis. Optimally designed set of machines for realization of this construction is included as well. The diploma thesis determines work procedures so as to take into account the economic aspect and time demands of construction.
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Hauler, Felix. "The ATPase VCP in viral infection and antiviral immunity." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707973.
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Axell, Per. "LAN Segmentering : Implementering av VTP version 3 och MST." Thesis, Mittuniversitetet, Avdelningen för informationssystem och -teknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-30882.
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Företaget är mitt uppe med att segmentera deras nätverk och anledningen till detta är att få en säkrare produktion med att skapa en kontrollerad och isolerad miljö, skydda mot spridning av virus och andra hot samt skapa en kostnadsbesparing genom att slippa uppdatera eller uppgradera utrustningar i onödan bara för att uppfylla nätverkspolicyn. För att underlätta företagets behov för segmentering har det här självständiga arbetet gått ut på att implementera VTP version 3 och MST. VTP skickar ut VLAN och MST uppdateringar runt i nätverket och underlättar vid användning av PVLAN. MST är ett Spanning Tree protokoll som gör det möjligt att mappa VLAN till instanser för på det sättet kunna spara CPU-belastning på switcharna samt att spara in på antal olika VLAN när PVLAN används. Metoden som användes var att sätta upp en testmiljö från backupper från riktiga nätet där det testades att implementera de nya protokollen samt att se hur de fungerade. En utvärdering av nätet gjordes där utvalda switchar och interfaces mättes innan implementationen för att senare jämföras med samma mätningar efter att implementationen var klar. Det visade sig att resultaten före implementeringen var så pass låga att implementeringen av MST sköts upp till att nätverkssegmenteringen var utförd. VTP version 3 implementerades utan problem och tre olika scenarier med färdiga konfigurationer skapades för att hjälpa företaget att ta steget över till MST i framtiden.The company is on the verge of segmenting their network and the reasons for this are to get a more secure production by creating a controlled and isolated environment, protecting against the spread of virus and other threats and aswell creating cost savings by not updating or upgrading unnecessary equipment just to meet the network policy. In order to facilitate the company's segmentation needs, this independent project has been about implementing VTP version 3 and MST. VTP sends out VLAN and MST updates around the network and ease the use of PVLAN. MST is a Spanning Tree protocol that enables VLAN to be mapped to instances to save CPU utilization on the switches as well to help load balance the network. The method used was to set up a test environment from backups from the real network where it was tested to implement the new protocols and to see how they acted. An evaluation of the network was made where selected switches and interfaces were measured before the implementation to be compared later with the same measurements after the implementation was completed. It turned out that the results before implementation were low enough that the implementation of MST was postponed until the network segmentation was completed. VTP version 3 was implemented without any problems and three different scenarios with complete configuration were created to help the company take the leap to MST in the future.
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Higgins, Mark. "Recovery of the reflection response for marine walkaway VSP." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/14064.
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The aim of walkaway VSP experiments is to image the region beneath the receiver. The information in the data is obscured by propagation effects in the region above the receiver such as free surface multiples, internal reflections and mode conversions. This thesis presents a method of extracting the reflectivity response of the region beneath the receiver from walkaway VSP data, assuming the earth to be horizontally stratified. For marine experiments the source is an acoustic source in the water. Measurements of source signatures clearly show shot-to-shot variations. VSP processing, such as the separation of upgoing and downgoing waves, is based on the assumption of shot-to-shot repeatability. However, shot-to-shot variations are usually ignored during processing. I present a straightforward method for correcting for these variations. The source signature must be measured and the geometry of the measurement must be known. The recorded source wavelets are all shaped to a standard wavelet using filters in the frequency domain. The same filters are applied to the geophone data, thus removing the effect of the source variations. The method is demonstrated on real data. As a plane horizontally-layered earth is laterally invariant, a walkaway VSP can be viewed as an experiment with a single source and a horizontal array of geophones at depth. The data are processed in the horizontal wavenumber-frequency domain, in which plane wave components are separated. I present a method for recovering the reflectivity of the region beneath the receiver in this domain. The full wavelength at the receiver level can be computed for a plane-horizontally layered earth as a superposition of plane wave responses.
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Campden, David A. "Analysis of multicomponent VSP data for shear-wave anisotropy." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/13301.
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Propagation characteristics of split shear-waves are studied to gain an understanding of the effects of attenuation anisotropy. It is shown that, compared to velocity anisotropy, attenuation anisotropy is a more difficult quantity to measure, being dependent on the attenuation of the faster split shear-wave and the velocity anisotropy. Measuring changes in attenuation anisotropy from repeated shear-wave experiments is also considered, with a view to monitoring EOR processes. Three automatic methods for measuring shear-wave splitting parameters are developed and tested on a synthetic VSP data set contaminated with different amounts of random noise. Standard signal processing techniques are investigated using the synthetic data, to determine whether they distort or improve observations on shear-wave splitting. VSPs from a North Sea gas field and the Geysers geothermal zone, California, are analysed for shear-wave splitting. The North Sea VSP consisted of four wide offset source locations, relying on P-waves being mode-converted to SV-waves at the top of the cap-rock overlying the gas saturated reservoir sands. Fast shear-wave polarizations and time delays are measured from shear-waves in the reservoir region using the three automatic techniques previously developed. Results suggest a predominant crack orientation of N47oW agreeing with maximum horizontal stress directions found from earthquake focal mechanisms and borehole breakout data. One of the main problems associated with these North Sea VSPs was that the source to borehole azimuths were very nearly parallel to the crack strike, resulting in poor observations of shear-wave splitting.
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DOS, SANTOS NAYARA FERNANDA BARROS. "Desenvolvimento de novos vetores para expressão de anticorpos e proteínas oligoméricas." reponame:Repositório Institucional da FIOCRUZ, 2016. http://www.arca.fiocruz.br/handle/icict/15764.
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Fiocruz
Instituto Carlos Chagas, Fiocruz-PR, Curitiba, PR, Brasil
Sistemas convencionais para expressão de anticorpos diméricos consistem em geral na co-transfecção de dois plasmídeos, cada um codificando uma das duas cadeias do anticorpo. Este trabalho teve por objetivo construir novos vetores para expressão simultânea das duas cadeias do anticorpo e outras proteínas oligoméricas a partir de um único plasmídeo, buscando melhorar o nível de expressão de proteínas heterodiméricas. A eficiência desses vetores foi testada para expressão do anticorpo dimérico constituído pelo Fab do anticorpo MEDI-493 fusionado à fração cristalizável de uma IgG1 humana selecionada devido à sua maior estabilidade. A escolha deste anticorpo foi baseada no seu potencial para o tratamento e diagnóstico rápido de infecções pelo Vírus Sincicial Respiratório Humano (hRSV). Os sistemas de expressão desenvolvidos neste projeto foram usados também para expressar partículas tipo-vírus (VLPs) de hRSV. As VLPs foram reconstituídas utilizando a combinação das proteínas G e M, ou F0 e M de hRSV. Sequências de aminoácidos do anticorpo e das VLPs foram usadas para gerar genes sintéticos que foram subclonados nos vetores de expressão. A expressão do anticorpo foi conduzida em células HEK293/HEK293T. Os melhores resultados foram obtidos com o plasmídeo baseado em dois cassetes de expressão. O anticorpo recombinante foi purificado a partir dos sobrenadantes da cultura celular por cromatografia de afinidade utilizando proteína A/G imobilizada em uma fase sólida e a expressão foi confirmada por Western Blot. O reconhecimento da F1, que é a proteína do hRSV que contém o epítopo alvo deste anticorpo, foi demonstrado inicialmente por Western Blot contra a proteína F1 recombinante. A atividade do anticorpo recombinante foi subsequentemente testada utilizando amostras de paciente infectados com o vírus hRSV por Western Blot em também por ensaios de ELISA. O anticorpo recombinante foi capaz de reconhecer as amostras clínicas com especificidade equivalente a do anticorpo comercial MEDI-493, confirmando seu potencial para aplicação em diagnóstico de infecções causadas pelo hRSV.
Conventional systems for expression of dimeric antibodies rely usually on cotransfection of two plasmids, each one coding one of the two antibody chains. The aim of this work was to construct new vectors for simultaneous expression of both antibodies chains and of other oligomeric proteins from a single plasmid, aiming to improve the level of expression of heterodimeric proteins. The efficiency of these vectors was tested for expression of a dimeric antibody constructed by using the Fab fragment of the antibody MEDI-493 with the crystallizable fraction of a human IgG1 selected based on its higher stability. This antibody was chosen based on its potential for treatment and rapid diagnostic of Respiratory Syncytial Virus (hRSV) infections. The expression system developed in this project was also used to express virus-like particles (VLPs) of hRSV. The hRSV VLPs were reconstituted using G and M, or F0 and M protein combinations. The amino acid sequences of this antibody and VLPs were used to generate nucleotide sequences. The respective genes were acquired from a gene synthesis company and subcloned into the new expression vectors. Expression of the recombinant antibody was conducted in HEK293/HEK293T cells in parallel experiments to compare the performance of the three different genetic constructs. Best results were obtained with a plasmid containing two expression cassettes, one for each antibody chain. The recombinant antibody was purified from cell culture supernatants by affinity chromatography using protein A/G immobilized on a solid phase and its presence was confirmed by Western Blot. Interaction of the recombinant antibody with its target on the hRSV F1 protein was determined by Western Blot. The activity of the recombinant antibody was tested using clinical specimens from patients infected with hRSV by Western Blotting and ELISA assays. The recombinant antibody was able to detect the F1 protein the clinical specimens with efficiency similar to the commercial antibody MEDI-493. This result indicates the recombinant antibody can be used for diagnosis of infections caused by hRSV.
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Andersson, Jenny, and Malin Johansson. "Vakuumisoleringspaneler ur ett livslängdsperspektiv." Thesis, KTH, Byggvetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-147544.
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Dagens energidebatt har lett till att ett mer energieffektiviserat byggande efterfrågas. Detta eftersom driften av byggnader kräver mycket energi, varför nya byggnadsmaterial och tekniker är nödvändiga. För att sänka energiförbrukningen krävs att behovet av mängden tillförd värme reduceras. Detta kan uppnås med en förbättrad värmeisolering. Nackdelen med traditionella isoleringsmaterial som till exempel mineralull är att en förbättrad värmeisolering kräver ökad värmeisoleringstjocklek. Detta leder i sin tur till tjockare ytterväggar, större materialåtgång och en minskad bo- eller uthyrningsbar yta. Sedan några år tillbaka har ett nytt värmeisoleringsmaterial börjat användas i byggnadssammanhang, nämligen vakuumisoleringspaneler (VIP). Dessa paneler tillverkas med en låg värmekonduktivitet och kan ge upp till nio gånger tunnare isoleringstjocklek jämfört med väggar isolerade med mineralull vid samma värmegenomgångskoefficient. En svaghet hos VIP ligger dock i dess beständighet, då flera faktorer kraftigt reducerar dess livslängd. Fokus i artikeln har lagts på vakuumisoleringspaneler gällande dess uppbyggnad och faktorer som påverkar dess livslängd. För att få en helhetsbild jämförs egenskaperna hos VIP med mineralull för att senare dra slutsatser om dess för- och nackdelar. Den goda värmekonduktiviteten hos VIP på 0.004 W/(m∙K) fås genom att ett vakuum skapas inuti dess kärna. Denna värmekonduktivitet är mycket känslig för yttre påverkan och förändras därför under materialets livstid. Minsta skada i panelen bidrar till att läckor uppstår och medför att vakuumet inuti kärnan går förlorat, vilket bidrar till en ökning av det inre trycket och panelens värmekonduktivitet. Detta på grund av att luft- och fuktmolekyler tränger in i kärnan via diffusion. På grund av detta läckage, vars storlek avgörs av faktorer som till exempel produktionskvalitet, panelstorlek och omgivande miljö åldras materialet snabbare och det i sin tur bidrar till att sänka materialets livslängd. I dagens läge anses mineralull vara det främsta valet av värmeisolering då vakuumisoleringspaneler uppvisar en mängd brister gällande beständighet och livslängd. Vakuumisoleringspaneler är även dyra, ömtåliga samt komplicerade att transportera och montera. För att VIP på allvar ska kunna konkurrera med mineralull vid val av värmeisolering krävs att utveckling sker för att reducera dess brister. Eftersom det idag ställs högre krav på tunnare ytterväggstjocklek och minskade värmeförluster från byggnader har VIP stor potential till att dess användning i byggnadssammanhang kommer att öka. Detta är fördjupningsdelen i ett arbete som också innefattar projektering och dimensionering av ett småhus.
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Barkarö, Amanda. "Identifiering av mastceller och vasoaktiv intestinal polypeptid och deras association till irritable bowel syndrome." Thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-129911.
Full textAbstract:
IBS (irritable bowel syndrome) is a functional gastrointestinal disorder which is estimated to affect one in ten individuals. It affects bowel function and leads to discomfort and pain for the patient. IBS can be subdivided into three separate groups named after the symptoms they bring: IBS-C (constipation), IBS-D (diarrhea) and IBS-M (mix). Today, there are no diagnostic markers for the disorder. The small and large intestine are regularly exposed to foreign substances and microorganisms; hence they contain a large number of immune cells of all sorts. Mastcells (MC) are pro-inflammatory cells and can be found in vast numbers in the intestine wall. They are thought to play an important role in the development of IBS. Studies has also shown that the neuropeptide vasoactive intestinal polypeptide (VIP) alter the function of the intestine and increased amount of VIP have been detected in plasma from IBS-patients. The purpose of this study was to compare the number of MCs and MCs containing VIP in colonic biopsies from: 6 healthy women, 6 women with IBS-D and 6 women with IBS-C. VIP in plasma was also measured in order to compare the amount between healthy and IBS-patients. MCs and VIP containing MCs were quantified using immunohistochemical techniques where the colonic tissue was double stained with antibodies directed towards mast cell tryptase and VIP. Evaluation of the immunostained tissue was performed using fluorescent microscopy. VIP in plasma was analysed using enzyme immunoassay (EIA). No significant difference in the number of MCs nor in MCs containing VIP was detected between the groups. However, significant differences in the amount of VIP in plasma was detected between healthy women and women with IBS-D. More studies are needed to elucidate the role of MC and VIP in the pathogenesis of IBS.
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DeHaven, Wayne I. "Pacap and vip modulation of neuroexcitability in rat intracardiac neurons." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001042.
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Highsmith, Jennifer Rea. "Changes in chromatic pattern-onset VEP with full-body inversion." abstract and full text PDF (free order & download UNR users only), 2007. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1446433.
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