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Literatura académica sobre el tema "43-386"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 9 de febrero de 2022

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Artículos de revistas sobre el tema "43-386"

Eatock, M. M., J. Szanto, N. C. Tebbutt, C. L. Bampton, A. H. Strickland, M. Valladares Ayerbes, N. Nanayakkara, Y. Sun, A. H. Adewoye y G. Bodoky. "Randomized, double-blind, placebo-controlled phase II study of AMG 386 in combination with cisplatin and capecitabine (CX) in patients (pts) with metastatic gastroesophageal adenocarcinoma." Journal of Clinical Oncology 29, n.º 4_suppl (1 de febrero de 2011): 66. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.66.

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66 Background: AMG 386, a first-in-class investigational peptide-Fc fusion protein (peptibody), blocks angiogenesis via inhibiting the interaction between angiopoietins-1 and -2 and the Tie2 receptor. We evaluated the efficacy and tolerability of AMG 386 or placebo plus CX in the first-line treatment of metastatic gastroesophageal adenocarcinoma. Methods: Pts with confirmed metastatic adenocarcinoma of the stomach, gastroesophageal junction or distal esophagus were randomized 1:1:1 to receive CX (cisplatin, 80 mg/m2 IV Q3W; capecitabine, 1,000 mg/m2 orally BID for 14 days Q3W) plus AMG 386 10 mg/kg (Arm A), 3 mg/kg (Arm B), or placebo (Arm C) IV QW. The primary endpoint was progression-free survival (PFS). Secondary endpoints included objective response rate (ORR; in pts with measurable disease), adverse events (AEs), and pharmacokinetics (PK). Results: 171 pts were randomized (Arm A/B/C, n = 56/59/56). Efficacy results are summarized in the table. The incidence of grade ≥ 3 AEs in Arms A/B/C was 80/84/75%. Serious AEs occurred in 73/60/47% and serious AEs grade ≥ 3 in 66/60/43% of pts. AEs in Arms A/B/C included abdominal pain (30/40/17%; grade ≥ 3, 18/3/4%), peripheral edema (13/29/6%; grade ≥ 3, 0/2/0%), venous thromboembolic events (20/22/19%; grade ≥ 3, 20/19/17%), and pulmonary embolism (9/3/15%; grade ≥ 3, 9/2/13%). Median AMG 386 Cmax and Cmin values at steady state after CX coadministration were dose-proportional. Coadministration with CX did not markedly affect AMG 386 exposure. Conclusions: In this study, AMG 386 plus CX did not significantly improve PFS or ORR over placebo plus CX in this patient population. The toxicity of the combination of AMG 386 plus CX, compared with placebo, was greater but manageable. No unexpected AEs occurred. [Table: see text] [Table: see text]

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Atkins, Michael B., Alain Ravaud, Gwenaelle Gravis, Kazimierz Drosik, Tomasz Demkow, Piotr Tomczak, Karolyn Kracht, Markus Puhlmann y David Michael Weinreich. "Safety and efficacy of AMG 386 in combination with sunitinib in patients with metastatic renal cell carcinoma (mRCC) in an open-label multicenter phase II study." Journal of Clinical Oncology 30, n.º 15_suppl (20 de mayo de 2012): 4606. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.4606.

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4606 Background: AMG 386, an investigational peptide-Fc fusion protein, inhibits angiogenesis by disrupting the angiopoietin/Tie2 axis. We evaluated the safety and efficacy of AMG 386 plus sunitinib in patients (pts) with mRCC. Methods: Adults with mRCC who were naïve to angiogenesis inhibitors were sequentially enrolled to 2 cohorts: sunitinib 50 mg PO QD (4 wks on, 2 wks off) plus AMG 386 at 10 mg/kg (A) or 15 mg/kg (B) IV QW. Primary endpoints: adverse events (AEs), dose interruptions/reductions due to AEs in the first 12 wks of treatment; secondary endpoints included: progression-free survival (PFS) and response rate (ORR). Results: 85 pts received ≥1 dose of study medication (A/B, n=43/42). In A/B, 88%/76% were male and 30%/36% were age ≥65; MSKCC risk scores were low (40%/36%) or intermediate (60%/62%). For A/B: median follow-up time was 19.6/12.0 mos; AMG 386 discontinuations due to AEs were 16%/29%; and grade ≥3 treatment-related AEs occurred in 72%/74% with virtually all attributed to sunitinib. Grade 3 AEs occurring with >5% frequency were hypertension, hand foot syndrome, asthenia, fatigue, elevated lipase, diarrhea, mucositis, vomiting, thrombocytopenia, and neutropenia, with no distinction between dose levels. The percentage of pts with sunitinib dose interruptions within the first 12 wks (A/B, 58%/57%) met the prespecified criteria. One pt in B had fatal acute pulmonary edema. No pt developed anti-AMG 386 antibodies. The Kaplan-Meier estimate (95% CI) of PFS was 13.9 (10.4, 19.2) mos in A; PFS in B is not yet mature with only 21% of pts having disease progression. ORR (95% CI) was 58% (42, 73) in A including 1 CR, and 59% (42, 74) in B. Conclusions: In pts with mRCC, AMG 386 at 10 and 15 mg/kg combined with sunitinib appeared to be tolerable. Reported sunitinib dose modifications for the observation period were within the prespecified range. Efficacy results suggest potential benefit for the addition of AMG 386 to sunitinib.

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Sly, L. I., M. A. Bronsdon, J. P. Bowman, A. Holmes y E. Stackebrandt. "The Phylogenetic Position of Helicobacter nemestrinae". International Journal of Systematic Bacteriology 43, n.º 2 (1 de abril de 1993): 386–87. http://dx.doi.org/10.1099/00207713-43-2-386.

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van Asselt, G. J., J. H. Sloos, R. P. Mouton, C. P. A. van Boven y J. A. M. van de Klundert. "Susceptibility of Streptococcus pyogenes to azithromycin, clarithromycin, erythromycin and roxithromycin in vitro". Journal of Medical Microbiology 43, n.º 5 (1 de noviembre de 1995): 386–91. http://dx.doi.org/10.1099/00222615-43-5-386.

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Reinhard, E., E. Nedivi, J. Wegner, J. H. Skene y M. Westerfield. "Neural selective activation and temporal regulation of a mammalian GAP-43 promoter in zebrafish". Development 120, n.º 7 (1 de julio de 1994): 1767–75. http://dx.doi.org/10.1242/dev.120.7.1767.

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Neurons throughout the vertebrate nervous system selectively activate the gene for a growth cone component, GAP-43, during embryonic development, and then decrease its expression abruptly as they form synapses. Distal interruption of mature axons in the central nervous system (CNS) of fish and amphibians, but not in the mammalian CNS reverses the developmental down-regulation of GAP-43 expression. To explore functional conservation and divergence of cis-acting elements that regulate expression of the GAP-43 gene, we studied activation, in transgenic zebrafish embryos, of mammalian GAP-43 genomic sequences fused to a marker gene. The DNA fragments containing the GAP-43 promoter, including a short fragment of 386 base pairs, were preferentially activated in the embryonic fish nervous system at times when extensive neuronal differentiation and neurite outgrowth take place. After 2 days of development, expression of the mammalian transgenes was specifically downregulated in the fish spinal cord but increased in more rostral regions of the CNS. This expression pattern was well correlated with the regulation of the endogenous fish GAP-43 gene revealed by in situ hybridization. Elements of the mammalian gene located a substantial distance upstream of the minimal promoter directed additional expression of the marker gene in a specific set of non-neural cells in zebrafish embryos. Our results indicate that cis-acting elements of the GAP-43 gene, and signaling pathways controlling these elements during embryonic development, have been functionally conserved in vertebrate evolution.

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McCall, W. Vaughn, Niki Boggs y Alan Letton. "Erratum to “Changes in sleep and wake in response to different sleeping surfaces: A pilot study” [Appl. Ergon. (43/2) 386–391]". Applied Ergonomics 43, n.º 3 (mayo de 2012): 637. http://dx.doi.org/10.1016/j.apergo.2011.11.001.

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Mwaisaka, Davidson Mghanga, George K'Aol y Caren Ouma. "Influence of directive and supportive leadership styles on employee job satisfaction in commercial banks in in Kenya". International Journal of Research in Business and Social Science (2147- 4478) 8, n.º 6 (26 de octubre de 2019): 168–74. http://dx.doi.org/10.20525/ijrbs.v8i6.468.

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The purpose of the study was to examine the influence of directive and supportive leadership style on employee job satisfaction in commercial banks in Kenya. The study adopted the positivism research philosophy and descriptive correlational research design. The target population of the study was 15,030 employees in all the 43 commercial banks licensed to operate in Kenya as of June 2018. Using a stratified sampling technique, the study drew a sample size of 386 employees reporting to middle-level managers. Data was collected by means of a questionnaire and analyzed using descriptive and inferential statistics. Statistical Package for Social Sciences (SPSS) version 20. The results of the study showed that a directive leadership style and supportive leadership styles positively and significantly predicted employee job satisfaction. The results of the regression analysis after moderation showed that environmental contingency factors significantly moderated the relationship between path-goal leadership style and employee job satisfaction.

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Mwaisaka, Davidson Mghanga, George K'Aol y Caren Ouma. "Influence of participative and achievement oriented leadership styles on employee job satisfaction in commercial banks in Kenya". International Journal of Research in Business and Social Science (2147- 4478) 8, n.º 5 (17 de agosto de 2019): 42–53. http://dx.doi.org/10.20525/ijrbs.v8i5.465.

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The purpose of the study was to examine the influence of participative and achievement-oriented leadership styles on employee job satisfaction in commercial banks in Kenya. This study adopted the positivism research philosophy while building a descriptive correlational research design. The target population of the study was 15,030 employees in all the 43 commercial banks licensed to operate in Kenya as of June 2018. , the study drew a sample size of 386 employees reporting to middle-level managers, using a stratified sampling technique. Data were collected utilizing a questionnaire and analyzed using descriptive and inferential statistics — statistical Package for Social Sciences (SPSS) version 20. The results of the study showed that a participative leadership style and achievement-oriented leadership styles positively and significantly predicted employee job satisfaction. From the results of the regression analysis after moderation, it was revealed that environmental contingency factors significantly moderated the relationship between path-goal leadership style and employee job satisfaction.

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Nargis, Tahmina, Md Humayun Kabir Talukder y Kazi Khairul Alam. "The hidden curriculum in under graduate medical education in Bangladesh: medical students' perception". Bangladesh Journal of Medical Education 4, n.º 1 (14 de abril de 2017): 20–24. http://dx.doi.org/10.3329/bjme.v4i1.32192.

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This descriptive cross sectional study was conducted among 386 students of 3rd phase of selected 2 government and 2 non government medical colleges of Bangladesh in 2013. The objective of the study was to find out the perceptions of the students regarding hidden curriculum in undergraduate medical education. Sampling technique was convenient. A self administered structured questionnaire was used and it consisting of 43 items in relation to hidden curriculum in the likert scale. Perceptions of the respondents were positive about 27 items that is the issues on these item areas were satisfactory in their institutes. Mean scores of these items were more than 3 for each. On the contrary perceptions of the respondents were negative for 16 items that is the issues on these item areas were not satisfactory in their institutes. Mean scores of these items were less than 3 for each. The study result can be used to sensitize and aware the concerned teachers/ authorities for valuing the importance of hidden curriculum and address the issues accordingly.Bangladesh Journal of Medical Education Vol.4(1) 2013: 20-24

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Duan, Zelin, Qing Li, Xuejie Li, Lin He y Qun Wang. "GSK3β is involved in the spermatogenesis of the Chinese mitten crab Eriocheir sinensis H. Milne Edwards, 1853". Crustaceana 89, n.º 5 (2016): 559–81. http://dx.doi.org/10.1163/15685403-00003543.

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Glycogen synthase kinase3β (GSK3β) is a Serine/Threonine kinase involved in metabolic reactions, and the Wnt, Akt, Hedgehog and BMP/Smad1 signalling pathways. It regulates cell metabolism, the cell cycle and cell fate through the phosphorylation of a diverse array of substrates. Its disorders lead to testicular degeneration, testicular cord disruption and many other reproductive diseases that often lead to infertility. In mammals, GSK3β plays an important role in the regulation of spermatogenesis. To explore functions of GSK3β during spermatogenesis inEriocheir sinensiswe cloned the full-lengthGSK3β cDNA sequence from the testis ofE. sinensis(EsGSK3β). The 1161-nucleotide open reading frame encodes a 386-amino-acid protein with a predicted molecular mass of 43 kDa. Additionally, we examined the expression pattern of EsGSK3β in different tissues and testis developmental stages using real-time PCR and Western blotting. Localization analysis ofEsGSK3β RNA and protein by in situ hybridization and immunofluorescence, respectively, showed that molecules translocated from the cytoplasm and nucleus to the regions of the acrosomal tubule and apical cap during spermatogenesis. The results indicated that EsGSK3β might play an important role duringE. sinensisspermatogenesis.

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Actas de conferencias sobre el tema "43-386"

Henry, Jody y Jackie Chambers. "Pipeline Appurtenance Alternatives". En Pipeline Division Specialty Conference 2010. Reston, VA: American Society of Civil Engineers, 2010. http://dx.doi.org/10.1061/41138(386)43.

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