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Tesis sobre el tema "Actin cytoskeleton"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 26 de julio de 2025

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1

Brown, Jennifer. "Investigating the actin cytoskeleton in cancer." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7266/.

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Dynamic alterations in the actin cytoskeleton, under the regulation of the Rho/ROCK pathway, permit cell motility, cell-to-cell and cell-to-matrix adhesion, and have also been shown to participate in apoptosis and cell proliferation. These facets of cellular behaviour all have the capacity to become dysregulated in cancer; components of the Rho/ROCK pathway are known to play varying roles in these processes, both within primary tumours and within the tumour microenvironment. The LIM kinases are phosphorylated and activated by ROCK, leading to inactivation of cofilin and subsequent stabilisatio

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2

Huber, Florian. "Emergent structure formation of the actin cytoskeleton." Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-86666.

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Anders als menschengemachte Maschinen verfügen Zellen über keinen festgeschriebenen Bauplan und die Positionen einzelner Elemente sind häufig nicht genau festgelegt, da die Moleküle diffusiven Zufallsbewegungen unterworfen sind. Darüber hinaus sind einzelne Bauteile auch nicht auf eine einzelne Funktion festgelegt, sondern können parallel in verschiedene Prozesse einbezogen sein. Basierend auf Selbstorganisation und Selbstassemblierung muß die Organisation von Anordnung und Funktion einer lebenden Zelle also bereits in ihren einzelnen Komponenten inhärent enthalten sein. Die intrazelluläre Or

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3

Förster, Florian. "Targeting the actin cytoskeleton with natural compounds." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168914.

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Targeting the cytoskeleton (CSK) of cancer cells offers a valuable strategy in cancer therapy. Whereas drugs which address microtubule CSK such as vinca alkaloids or taxanes are well established in the clinic, compounds binding to the actin CSK are still far away from their therapeutical application. One reason might be the lacking knowledge on their mode of cytotoxicity and moreover their tumor specific mechanism of action. We used the myxobacterial compound Chondramide as a tool to first elucidate the mechanisms of cytotoxicity by actin targeting in different breast cancer cells, namely MC

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4

Kim, Taeyoon Ph D. Massachusetts Institute of Technology. "Simulation of actin cytoskeleton structure and rheology." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39875.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.<br>Includes bibliographical references (p. 81-87).<br>Structures consisting of G-actin or other filament-forming monomers show a variety of morphologies with widely different properties in regard to pore size, degree of isotropy, and extent of cross-linking. These characteristics are primarily determined by the concentration and feature of proteins which cross-link filaments, but little is known how the filament-forming monomers and cross-linking proteins are organized in order to produce various netwo

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5

Gallinger, Julia. "WH2 domains and actin variants as multifunctional organizers of the actin cytoskeleton." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-161698.

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Actin is one of the most abundant proteins in eukaryotic cells and regulation of the microfilament system is crucial for a wide range of cellular functions including cell shape, cell motility, cell division and membrane dynamics. The aim of this thesis was (1) to gain a better understanding of the function of distinct actin binding domains in the regulation of the actin cytoskeleton and (2) to elucidate the role of actin variants. WH2 domains (WH2, Wiskott-Aldrich syndrome protein homology 2) are ubiquitous multifunctional regulators of actin dynamics. The protein Spire contains four central

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6

Speldewinde, Shaun. "Prions, autophagy, ageing and actin cytoskeleton in yeast." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/prions-autophagy-ageing-and-actin-cytoskeleton-in-yeast(03085d7f-283a-40e1-bcf7-d9533ff2e2fc).html.

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Prions are infectious protein entities capable of self-replication. Prions are the causal agents behind the transmissible spongiform encephalopathies causing neurodegeneration and death in affected organisms. Prions have been identified in yeast with the best-characterized prions being [PSI+] and [PIN+], whose respective native proteins are the Sup35 translation termination factor and Rnq1 (function unknown). Autophagy is a cellular housekeeping mechanism mediating the degradation of damaged proteins and superfluous organelles. It is a highly sequential process regulated by autophagy related g

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7

Hayot, Caroline. "Mise au point d'une stratégie pharmacologique originale pour l'obtention de composés anti-cancéreux anti-migratoires." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210860.

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La migration cellulaire est une étape clé intervenant à un stade précoce de la dissémination des cellules cancéreuses dans l’organisme, et est donc responsable de la formation des métastases qui tuent environ nonante pourcent des patients atteints de cancer. De plus, ces cellules migrantes résistent à l’apoptose grâce à l’activation constitutive de voies de signalisation anti-apoptotiques, et développent donc une résistance vis-à-vis des traitements anti-cancéreux actuels qui sont généralement pro-apoptotiques. Nous avons pris pour cible ce processus de migration cellulaire dans l’espoir d’ide

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8

Thodey, Catherine. "Actin cytoskeleton dynamics mediate sugar response in Arabidopsis thaliana." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518364.

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9

Price, Leo Sebastian. "Secretion and the actin cytoskeleton in rat mast cells." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307776.

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10

Filippi, Beatrice Maria. "Cellular effects of phosphoinositide derivatives on the actin cytoskeleton." Thesis, Open University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424620.

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11

Dickinson, Sarah. "Regulation of the actin cytoskeleton by ephrin-B signalling." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445415/.

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Ephrin ligands and their Eph receptors play an essential role in angiogenesis during development. Both ephrins and Eph receptors are membrane-tethered proteins and their interaction at sites of cell-cell contact triggers bi-directional signalling, with signals transduced from the receptor (forward signalling) and ligand (reverse signalling). I have used two model systems to study ephrin-B2 signalling: Swiss 3T3 fibroblasts expressing exogenous ephrin-B2 and Human Umbilical Arterial Endothelial Cells (HUAECs) endogenously expressing ephrin-Bs. Stimulation of ephrin-B2 with soluble EphB receptor

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12

Caution, Kyle J. "Legionella pneumophila and caspases: modulation of the actin cytoskeleton." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1449147516.

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13

Martin, Stuart S. "Phosphoinositide-dependent regulation of the actin cytoskeleton by insulin /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9904827.

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14

Lardennois, Alicia. "Contribution of actin cytoskeleton to C. elegans embryonic elongation." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS236.pdf.

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Les processus morphogénétiques impliquent des changements de forme de cellules, via des forces mécaniques, qui doivent être stabilisés. Ma thèse vise à élucider comment l'embryon de C. elegans, matériau élastique, s'allonge progressivement sous l’effet des contractions musculaires. Un crible ARNi en fond pak-1(Ø), kinase de l’épiderme impliquée dans une cascade de mécanotransduction en aval des muscles, a identifié SPC-1/α-spectrine, comme partenaire probable. Les embryons spc-1(-)pak-1(-) s'allongent jusqu'à 1.5-fold, puis reviennent à leur taille initiale sous l’effet des muscles. Avec la mi

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15

Rodrigues, Joana Nogueira. "Dissecting the role of adducin in the axonal cytoskeleton." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14771.

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Mestrado em Biologia Molecular e Celular<br>The neuronal cytoskeleton is an interconnected network of filamentous polymers, having in its constitution three major components: actin, microtubules and intermediate filaments. Up to the discovery of axon actin rings, the neuronal actin cytoskeleton has gained relevance. Still, the molecular details of the regulation of the actin cytoskeleton in neurons are largely unknown. Helping in the actin cytoskeleton regulation and maintenance, there is adducin. Adducin is organized in heterotetamers of heterodimers which comprises α/β and α/γ subunit

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16

Hosu, Basarab Gabriel. "Quantitative biological studies at cellular and sub-cellular level." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4689.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed Mar. 23, 2009). Vita. Includes bibliographical references.

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17

Cavazzini, Michele G. "Dynamics of the actin cytoskeleton in plasticity of neurotransmitter release." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531957.

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18

Strasser, Geraldine A. "Regulation of the actin cytoskeleton in the neuronal growth cone." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/31182.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2005.<br>Includes bibliographical references (leaves 94-111).<br>During the development of the nervous system, axons and dendrites are guided to their targets throughout the brain and body through the detection of diffusible and surface-bound guidance cues. The growth cone, a specialized structure found at the tips of axons and dendrites, detects and interprets these cues. Activation of downstream intracellular singling pathways leads to changes in the cytoskeleton of the growth cone that affect its motility. Although a

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19

Smith, Katherine. "Manipulation of the host actin cytoskeleton by enteropathogenic Escherichia coli." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608524.

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20

Coruche, Gaspar P. M. "Investigating the role of the actin cytoskeleton in hippo signalling." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1414999/.

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The Hippo pathway is composed of a phosphorylation cascade involving the kinases Hippo/MST and Warts/LATS, which inactivate the pro-growth transcriptional co-activator Yorkie/YAP. By sensing the status of the actin cytoskeleton, Yorkie/YAP is believed to respond to cell crowding and the rigidity of the environment, but the molecular details and in vivo relevance of this remain unclear. I have investigated the role of mechanical cues and the actin cytoskeleton, in the regulation of Yorkie/YAP. I have applied several forms of mechanical stresses to cell cultures and present evidence to suggest t

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21

Pieri, Maria. "Regulation of vascular smooth muscle actin cytoskeleton by Hic-5." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/regulation-of-vascular-smooth-muscle-actin-cytoskeleton-by-hic5(3309e74d-0a10-4d04-b741-a99f64075620).html.

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Vascular smooth muscle cells (VSMC) constitute an important component of blood vessels and are primarily responsible for vessel contraction. In vascular disorders such as hypertension and atherosclerosis as well as pregnancy and exercise, VSMC demonstrate increased capacity to proliferate and migrate, resulting in vascular remodelling. The actin cytoskeleton is an important component of vascular contractility and is also essential for proliferation and migration of VSMC. Vasoactive agonists such as Endothelin-1 (ET-1) and Noradrenaline (NA), have been shown to mediate VSMC contraction through

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22

Li, Tong. "Cross-scale biophysics modelling of F-actin cytoskeleton in cell." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/82293/1/Tong_Li_Thesis.pdf.

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This thesis is a comparative study of the modelling of mechanical behaviours of F-actin cytoskeleton which is an important structural component in living cells. A new granular model was developed for F-actin cytoskeleton based on the concept of multiscale modelling. This framework overcomes difficulties encountered in physical modelling of cytoskeleton in conventional continuum mechanics modelling, and the computational challenges in all-atom molecular dynamics simulation. The thermostat algorithm was further modified to better predict the thermodynamic properties of F-actin cytoskeleton in mo

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23

Marks, John. "Cytological and biochemical investigation of actin in the fission yeast Schizosaccharomyces pombe." Thesis, University College London (University of London), 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337930.

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24

Alhassan, Hassan Hamdan. "The Role of the Actin Cytoskeleton in Asymmetric Cell Division in Maize." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc699951/.

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Stomata are specialized plant structures required for gaseous exchange with the outer environment. During stomata formation, the cytoskeleton plays an important role in controlling the division of the individual cells leading to the generation of the stomata complex. Two mutants that affect microfilament and microtubule organization in subsidiary mother cells include brk1 and dcd1. While only 20% of the subsidiary cells in the brk1 and dcd1 single mutants are abnormally shaped, it was reported that there is a synergistic effect between the brk1 and dcd1 mutations in the brk1; dcd1 double muta

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25

Sullivan, Richard. "Regulation of actin and secretion by Rho and calmodulin." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313497.

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26

McNaughton, Fergus Samuel. "The Role of F-actin in Hyphal Branching." Thesis, University of Canterbury. Biological Sciences, 2005. http://hdl.handle.net/10092/1288.

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Hyphal organisms are a commonly used model system for studies of polarised growth. While growing hyphal tips offer a good example of polarised growth, little detail of the process of polarisation can be determined from them. Hyphal branching offers a good example of the development of polarity, however to date it has been largely impractical to study hyphal branching, due to the irregular timing and location along the hypha of natural branch formation. Chemical induction of branches circumnavigates this problem, using a localised concentration of nutrients adjacent to the growing hypha to stim

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27

Newcombe, Anthony Richard. "The biochemical role of the small G protein Rac1 in cell signalling pathways : interaction with RhoGDI and the phagocyte NADPH oxidase component, p67'p'h'o'x." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342224.

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28

McShea, Molly A. "Evidence of an interaction between the actin cytoskeletal regulators MIG-10 and ABI-1." Digital WPI, 2011. https://digitalcommons.wpi.edu/etd-theses/983.

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"Cell and process migration are critical to the establishment of neural circuitry. The study of these processes is facilitated through use of model organisms with simple nervous systems, such as C. elegans. Research in this nematode has defined the cytoplasmic adaptor MIG-10 as a key regulator of these processes. Mutation of mig-10 disrupts neuronal and axonal migration and outgrowth of the â€˜canalsâ€™, or processes, of the excretory cell. MIG-10 directs the localization of UNC-34, which remodels actin filaments at the leading edge of a migrating cell or process to modify the direction or rat

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29

Thurston, Susan Frances. "INF1 is a novel microtubule and actin cytoskeleton cross-linking protein." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28394.

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Formin proteins, characterized by two conserved formin homology (FH) domains, play an important role in cytoskeletal regulation and dynamics. The FH domains are most commonly implicated with the polymerization of F-actin and more recently with the stabilization of microtubules. Inverted formin 1 (INF1) is an atypical formin that has its FH1 and FH2 domains in its N-terminus. The C-terminus of INF1 contains five conserved regions unlike any other sequence found in the database. In this study, we demonstrate that INF1 discreetly associates with microtubules via a unique bipartite microtubule-bin

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30

Dufort, Paul Anthony. "Computational modeling of nucleotide processing by the actin cytoskeleton regulatory network." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0022/NQ49953.pdf.

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31

Fulzele, Keertik S. "ROLE OF ACTIN CYTOSKELETON FILAMENTS IN MECHANOTRANSDUCTION OF CYCLIC HYDROSTATIC PRESSURE." MSSTATE, 2004. http://sun.library.msstate.edu/ETD-db/theses/available/etd-07122004-171347/.

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This research examines the role of actin cytoskeleton filaments in chondroinduction by cyclic hydrostatic pressurization. A chondroinductive hydrostatic pressurization system was developed and characterized. A pressure of 5 MPa at 1 Hz frequency, applied for 7200 cycles (4 hours intermittent) per day, induced chondrogenic differentiation in C3H10T1/2 cells while 1800 cycles (1 hour intermittent) did not induce chondrogenesis. Quantitative analysis of chondrogenesis was determined as sulfated glycosaminoglycan synthesis and rate of collagen synthesis while qualitative analysis was obtained as A

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32

Liu, Chaohong. "Regulatory functions of the actin cytoskeleton in B cell receptor signaling." Thesis, University of Maryland, College Park, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3599621.

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<p> The binding of antigen (Ag) to the B cell receptor (BCR) induces the activation of intracellular signaling and the reorganization of the actin cytoskeleton. However, the function of actin reorganization and the mechanisms by which BCR signaling and actin reorganization is coupled have not been well studied. This thesis has investigated how BCR signaling regulates actin reorganization and how actin remodeling in turn influences BCR signalig. My studies show that the key stimulatory signaling molecule of the BCR, Bruton's tyrosine kinase (Btk), is critical for actin polymerization at the act

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33

Hartemink, Christopher Allan 1974. "The cross-linking mechanism of filamin A in the actin cytoskeleton." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33071.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2005.<br>Includes bibliographical references (p. 109-119).<br>Eukaryotic cells are permeated by a three-dimensional network of entangled filamentous proteins termed the cytoskeleton. Like scaffolding, the cytoskeleton provides rigidity and resistance to deformation from forces transmitted to and from the cell membrane. In order to model the mechanics of the cytoskeleton, the interaction of individual structural proteins must be established. To this end the relationship between two critical proteins of the actin cytoskelet

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34

Curnock, Rachel Marie. "The regulation of actin cytoskeleton dynamics and membrane trafficking by ARHGAP44." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685144.

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Membrane shape is dynamic, and cellular membranes adopt different curvatures during fundamental vesicle trafficking events. This is exemplified by the concept of iterative, geometric based sorting. The BAR (Bin/Amphiphysin/Rvs) domain protein superfamily is the largest group of proteins responsible for generating membrane curvature. The work presented in this thesis has examined the cellular function of the BAR domain containing Rho GTPase-activating protein 44 (ARHGAP44; also known as RhoGAP interacting with CIP4 homologs 2 (RICH2)). Recent studies have strongly suggested that ARHGAP44 contri

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35

Edwards, David C. "LIM kinase : the connection between Rac/Cdc42 and the actin cytoskeleton /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9917949.

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36

Johnson, Matthew. "Regulation of the actin cytoskeleton and polarized growth in Schizosaccharomyces pombe." Thesis, University of Kent, 2014. https://kar.kent.ac.uk/48729/.

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The fission yeast, Schizosaccharomyces pombe grows only in length in a highly polarized manner in a process tightly regulated by both the microtubule and actin cytoskeletons, which play key roles in the establishment of cell polarity and growth of the cell respectively. Previous studies have shown that within the microtubule cytoskeleton a large group of proteins accumulate at the cell poles, where they are believed to form a “polarisome” which coordinates the cell’s polarity. Whilst the main functions and key interactions between these proteins are known, many of the finer details remain uncl

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37

Walker, Sophie. "Changes to the cytoskeleton and cell wall underlie invasive hyphal growth." Thesis, University of Canterbury. Biological Sciences, 2004. http://hdl.handle.net/10092/1313.

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Tip growth is a form of cellular expansion characteristic of fungal hyphae and some types of plant cells. Currently there is no unified model that satisfactorily describes this in hyphal species. Traditionally turgor has been considered an essential driving force behind cell expansion. In recent years this hypothesis has been challenged by evidence that in some species tip growth can occur despite the absence of measurable hydrostatic pressure. There are currently two contentious theories of hyphal extension. These are the turgor-driven model and the amoeboid-movement theory. Though the

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38

Gallinger, Julia [Verfasser], and Michael [Akademischer Betreuer] Schleicher. "WH2 domains and actin variants as multifunctional organizers of the actin cytoskeleton / Julia Gallinger. Betreuer: Michael Schleicher." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1043906355/34.

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39

Berepiki, Adokiye. "Function and organisation of actin and septins in Neurospora crassa." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/7605.

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This thesis deals with the organisation and function of actin and septins in the model filamentous fungus, Neurospora crassa. Firstly, study demonstrates the utility of the Lifeact peptide probe for the investigation of actin dynamics in N. crassa. Lifeact fused to fluorescent proteins allowed live-cell imaging of actin patches, cables and rings without interfering with cellular functions. Actin cables and patches localised to sites of active growth during the establishment and maintenance of cell polarity in germ tubes and conidial anastomosis tubes (CATs). Recurrent phases of formation and r

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40

Beardsley, Andrew. "Caveolin-1 recruitment to the trailing edge of motile cells results in focal adhesion disassembly and nascent interaction with actin stress fibers." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4821.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains viii, 160 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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41

Dewar, Hilary. "Characterisation of the domain in Sla1p required for regulation of the yeast actin cytoskeleton." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248135.

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42

Berndt, Christine Charlotte. "Characterization of human syndecan-3 and its influence on the actin cytoskeleton." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966003055.

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43

Guolla, Louise. "Force Transduction and Strain Dynamics through Actin Stress Fibres of the Cytoskeleton." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20272.

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It is becoming clear that mechanical stimuli are critical in regulating cell biology; however, the short-term structural response of a cell to mechanical forces remains relatively poorly understood. We mechanically stimulated cells expressing actin-EGFP with controlled forces (0-20nN) in order to investigate the cell’s structural response. Two clear force dependent responses were observed: a short-term local deformation of actin stress fibres and a long-term force-induced remodelling of stress fibres at cell edges, far from the point of contact. We were also able to quantify strain dynamics oc

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44

Goosney, Danika Louise. "Enteropathogenic Escherichia coli (EPEC) interactions with the host epithelial cell actin cytoskeleton." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61095.pdf.

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45

Crimaldi, Luca. "Recruitment of podosome components involved in the remodelling of the actin cytoskeleton." Thesis, Open University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503623.

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46

Reyhani, Vahid. "Extracellular Matrix and Actin Cytoskeleton - the Control Unit of Interstitial Fluid Volume." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-217027.

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The regulation of fluid (water) volume in the body is crucial for tissue homeostasis. The interstitial fluid, which comprises almost 20% of the body fluid, is stored in the loose connective tissue and its volume is actively regulated by components of this tissue. The loose connective tissue provides a path for fluid flow from capillaries to the tissue and lymphatics. This fluid is partially stored in the interstitium and the remainder is directed to the lymphatics. The fibroblasts in the loose connective tissue actively compact the fibrous extracellular matrix (ECM) through mechanotransduction

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Conway, B. R. "Role of the actin cytoskeleton in the genetic susceptibility to diabetic nephrology." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398146.

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Gheorge, Dana Mihaela. "Mapping the interactions of Scp1p with the actin cytoskeleton of Saccharomyces cerevisiae." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440954.

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Pendleton, Annmarie. "Participation of the actin cytoskeleton in the secretory function of mast cells." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391514.

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Mondal, Chandrani. "Mena 11a-isoform specific regulation of actin cytoskeleton organization and cell behavior." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103241.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>EnaNASP proteins are a conserved family of actin regulatory proteins that modulate cell motility and morphology by altering actin dynamics. Mena, an EnaNASP protein, is alternatively spliced, producing protein isoforms with distinct functions. Here, we characterize the expression, function, and regulation of the Mena11a splice isoform at the molecular and cellular level. We find that Menal 1 a is enriched in epithelia and muscle

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